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Добірка наукової літератури з теми "Cytokines"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 31 липня 2024

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Статті в журналах з теми "Cytokines"

1

Trinchieri, Giorgio. "Cytokines and cytokine receptors." Immunological Reviews 202, no. 1 (December 2004): 5–7. http://dx.doi.org/10.1111/j.0105-2896.2004.00217.x.

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2

Dayer, J. M. "Cytokines and cytokine antagonists." Fresenius' Journal of Analytical Chemistry 343, no. 1 (1992): 33–34. http://dx.doi.org/10.1007/bf00331973.

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3

Berti, E., and R. Caputo. "Cytokines, cytokine receptors and cytokine antibodies." Melanoma Research 6, SUPPLEMENT 1 (September 1996): S25. http://dx.doi.org/10.1097/00008390-199609001-00064.

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4

van Deventer, S. J. H. "Cytokines and cytokine-based therapies." Current Opinion in Gastroenterology 14, no. 4 (July 1998): 317–21. http://dx.doi.org/10.1097/00001574-199807000-00008.

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5

Li, Aileen W., and Wendell A. Lim. "Engineering cytokines and cytokine circuits." Science 370, no. 6520 (November 26, 2020): 1034–35. http://dx.doi.org/10.1126/science.abb5607.

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6

Burger, D., and J. M. Dayer. "Inhibitory cytokines and cytokine inhibitors." Neurology 45, Issue 6, Supplement 6 (June 1, 1995): S39—S43. http://dx.doi.org/10.1212/wnl.45.6_suppl_6.s39.

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7

Ansel, John, Patricia Perry, Jeffrey Brown, David Damm, Tuan Phan, Charles Hart, Thomas Luger, and Stephen Hefeneider. "Cytokine Modulation of Keratinocyte Cytokines." Journal of Investigative Dermatology 94, no. 6 (June 1990): s101—s107. http://dx.doi.org/10.1111/1523-1747.ep12876053.

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8

Thipphawong, John. "Inhaled cytokines and cytokine antagonists." Advanced Drug Delivery Reviews 58, no. 9-10 (October 2006): 1089–105. http://dx.doi.org/10.1016/j.addr.2006.07.014.

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9

Ramani, Thulasi, Carol S. Auletta, Daniel Weinstock, Barbara Mounho-Zamora, Patricia C. Ryan, Theodora W. Salcedo, and Gregory Bannish. "Cytokines." International Journal of Toxicology 34, no. 4 (May 26, 2015): 355–65. http://dx.doi.org/10.1177/1091581815584918.

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Анотація:

Over the past 30 years, the world of pharmaceutical toxicology has seen an explosion in the area of cytokines. An overview of the many aspects of cytokine safety evaluation currently in progress and evolving strategies for evaluating these important entities was presented at this symposium. Cytokines play a broad role to help the immune system respond to diseases, and drugs which modulate their effect have led to some amazing therapies. Cytokines may be “good” when stimulating the immune system to fight a foreign pathogen or attack tumors. Other “good” cytokine effects include reduction of an immune response, for example interferon β reduction of neuron inflammation in patients with multiple sclerosis. They may be “bad” when their expression causes inflammatory diseases, such as the role of tumor necrosis factor α in rheumatoid arthritis or asthma and Crohn’s disease. Therapeutic modulation of cytokine expression can help the “good” cytokines to generate or quench the immune system and block the “bad” cytokines to prevent damaging inflammatory events. However, care must be exercised, as some antibody therapeutics can cause “ugly” cytokine release which can be deadly. Well-designed toxicology studies should incorporate careful assessment of cytokine modulation that will allow effective therapies to treat unmet needs. This symposium discussed lessons learned in cytokine toxicology using case studies and suggested future directions.

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10

Standiford, Theodore. "Anti-inflammatory Cytokines and Cytokine Antagonists." Current Pharmaceutical Design 6, no. 6 (April 1, 2000): 633–49. http://dx.doi.org/10.2174/1381612003400533.

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Дисертації з теми "Cytokines"

1

Webb, Ginette Rachel. "Cytokines and cytokine receptors in osteoarthritis." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388158.

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2

Deller, Marc Christian. "Structural studies of cytokines and cytokine receptors." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326028.

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3

Palmblad, Karin. "Cytokines and cytokine-directed intervention in experimental arthritis /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4589-6/.

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4

Affò, Silvia. "Cytokines and Cytokine-Receptors in the Pathogenesis of Alcoholic Hepatitis." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/145435.

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By performing a translational study we identified a specific pattern of genes differentially regulated in patients with severe alcoholic hepatitis (AH). A functional analysis of the gene expression profile showed several pathways deregulated in AH, including cytokines- cytokine receptor interaction. Within cytokine-cytokine receptor interaction pathway, Fn14 has been identified as the only receptor belonging to TNF superfamily to be exclusively up-regulated in patients with AH, and its expression has been shown to be associated with severity of the disease and mortality. We observed that Fn14 is upregulated in experimental models of progenitor cell expansion and co-expressed with Ep-CAM in livers of patients with AH, suggesting that Fn14 may regulate ductular reaction expansion. Moreover, we showed that Fn14 hepatic expression is regulated by ethanol and pro-fibrogenic factors, suggesting that alcohol abuse together with fibrogenic mediators may be directly responsible for the induction of Fn14 expression in ALD. Furthermore, transcriptome analysis identified CCL20 as the most up-regulated cytokine in the liver of patients with AH. Hepatic expression and serum levels of CCL20 have been found elevated in patients with AH and have been showed to be associated with key clinical features of the disease such as fibrosis, endotoxemia and short-term mortality. These data suggest that besides playing a role in AH pathogenesis, CCL20 may also be considered as a potential non-invasive biomarker. We found that CCL20 hepatic expression is up-regulated in acute, chronic and acute-on chronic experimental model of liver injury induced by carbon tetrachloride (CCl4) and lipopolysaccharide (LPS) and their combination, respectively. Macrophages and hepatic stellate cells have been identified as the main CCL20 producing cell types in experimental models of acute-on-chronic liver injury. Moreover, we have showed that CCL20 exerts pro-fibrogenic and pro-inflammatory and effects on primary human hepatic stellate cells and on macrophages, suggesting that CCL20 may participate in both hepatic fibrosis and inflammation during liver disease in an autocrine and paracrine manner. Finally, we have found that CCL20 mediates LPS-induced liver injury by promoting hepatocellular apoptosis, expression of pro-inflammatory and pro-fibrogenic mediators and by enhancing macrophages and neutrophils infiltrate recruitment. In conclusion, during this thesis we performed two studies leading to the identification of new potential targets for therapy in AH. The identification of Fn14 and CCL20 as new potential targets for therapy in AH and their correlations with key hallmarks of the disease such as ethanol consumption, fibrosis, progenitor cells expansion and endotoxemia underline the complexity of this disease and the crosstalk between many mediators that occurs in AH. The data presented in this thesis suggest that cytokines and cytokine-receptor pathway could represent a new potential target for therapy in ALD; and also provide new important insights and a useful resource for the study of the pathogenesis of this disease.
El consumo de alcohol es una de las causas más importantes de mortalidad que pueden prevenirse en nuestro país. La hepatitis alcohólica (HA) se caracteriza por un proceso de inflamación hepática (fundamentalmente por infiltración de células polimorfonucleares), esteatosis masiva hepática, fibrosis pericelular y daño hepatocelular. En la actualidad no existen tratamientos efectivos para el tratamiento de la HA y por esta razón, existe una clara necesidad de identificar nuevas dianas terapéuticas para tratar a estos pacientes en los diferentes estadios de la enfermedad (esteatosis, inflamación y/o fibrogénesis). El objetivo principal de esta tesis fue investigar nuevas dianas terapéuticas para el tratamiento de la HA. Para alcanzar dicho objetivo, realizamos estudios traslacionales que permitieran identificar marcadores biológicos alterados en muestras humanas procedentes de hígados de pacientes con HA para estudiar la función que tienen en el desarrollo de la enfermedad in vitro e in vivo en modelos animales de diferentes tipos de daño hepático y valorar si podrían considerarse como dianas terapéuticas. Mediante la performación de nuestros estudios, identificamos a la vía de citoquinas-receptores de citoquinas como una de las vías con el mayor número de genes diferentemente regulados en pacientes con HA con respecto a controles sanos. Estudios en muestras humanas y en modelos animales de daño hepático nos permitieron identificar al receptor de citoquinas Fn14 y a la citoquina CCL20 como importantes mediadores de la HA, correlacionados tanto con aspectos clínicos característicos así como con la gravedad de la enfermedad. La vía de citoquinas y receptores de citoquinas y, de manera específica Fn14 y CCL20 han sido identificados como novedosos mediadores implicados en la patogénesis de la HA y por lo tanto como potenciales dianas terapéuticas. Por lo tanto, gracias a la identificación de un patrón de los genes diferentemente regulados en la HA, nuestros datos proporcionan importantes resultados novedosos para el estudio de la patogénesis de la HA.

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5

Ozaki, Akihiko. "Expression of cytokines and cytokine receptors in human Schwann cells." Kyoto University, 2008. http://hdl.handle.net/2433/135921.

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6

LU, ZHAO-YANG. "Cytokines et antagonistes de cytokines dans le myelome multiple." Nantes, 1993. http://www.theses.fr/1993NANT2079.

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Notre equipe a montre que l'interleukine-6 (il-6) est un facteur essentiel pour la croissance des cellules plasmocytaires malignes et que des traitements par anticorps anti-il-6 reduisaient croissance tumorale chez 50% des malades. La premiere partie de notre travail a consiste a rechercher les raisons pouvant expliquer une non-reponse au traitement. Nous avons ainsi developpe une methodologie nouvelle permettant de quantifier la production journaliere d'il-6 dans tout l'organisme. Nous avons montre que la production d'il-6 chez les malades non repondeurs etait trop forte, superieure au moins a 70 mg/jour, pour pouvoir etre inhibee par l'anticorps anti-il-6. Dans la deuxieme partie de notre travail, nous montrons que les 4 cytokines utilisant la meme chaine transductrice que l'il-6 sont egalement des facteurs de croissance plasmablastique (cntf, lif, il-11, osm). De plus, nous montrons que l'il-10, une nouvelle cytokine jouant un role important dans la differenciation lymphocytaire b normale, est egalement un puissant facteur de croissance des plasmocytes tumoraux. Ces resultats invitent a preciser rapidement le role eventuel joue par ces cytokines dans l'emergence du myelome multiple in vivo. Enfin, nous avons recherche des proteines pouvant bloquer la proliferation des cellules tumorales. Nous montrons que l'ifn-9 est un puissant inhibiteur en bloquant entre autre l'expression des recepteurs de l'il-6. L'antagoniste du recepteur de l'il-1 (il-ira) est un autre inhibiteur interessant capable de bloquer l'activation de l'environnement tumoral a produire de l'il-6. Cette activation est mediee par les pge-2 induites par l'il-1. En conclusion, l'etude des cytokines dans le myelome multiple permet de comprendre certains des mecanismes oncogeniques impliques dans cette pathologie et d'envisager des applications therapeutiques immediates de ces concepts

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7

Croxford, J. Ludovic. "Gene therapy for experimental allergic encephalomyelitis by delivery of inhibitory cytokines or cytokine inhibitors." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314201.

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8

Ulfgren, Ann-Kristin. "Cytokines in rheumatoid arthritis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3823-7/.

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9

Benrick, Anna. "Cytokines in metabolic functions /." Göteborg : Section of Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 2008. http://hdl.handle.net/2077/9608.

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10

Gilmore, William Hans. "Canine pro-inflammatory cytokines." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263791.

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Книги з теми "Cytokines"

1

Ibelgaufts, Horst. Dictionary of cytokines. Weinheim: VCH, 1995.

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2

Meager, Anthony. Cytokines. Englewood Cliffs, N.J: Prentice Hall, 1991.

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3

Meager, Anthony. Cytokines. Milton Keynes [England]: Open University Press, 1990.

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4

Callard, R. E. The cytokine factsbook. London: Academic Press, 1994.

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5

Meager, Anthony. Cytokines. Englewood Cliffs, N.J: Prentice Hall, 1991.

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6

A, Wells James, ed. Cytokines. San Diego: Academic, 1999.

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7

Meager, A. Cytokines. Milton Keynes: Open University Press, 1990.

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8

Constantin, Bona, and Revillard Jean-Pierre, eds. Cytokines and cytokine receptors: Physiology and pathological disorders. Amsterdam: Harwood Academic, 2000.

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9

Westwick, J., I. J. D. Lindley, and S. L. Kunkel, eds. Chemotactic Cytokines. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-6009-4.

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10

1950-, Nicola Nicos, ed. Guidebook to cytokines and their receptors. Oxford: Oxford University Press, 1994.

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Частини книг з теми "Cytokines"

1

Behrens, Edward M. "Cytokines in Cytokine Storm Syndrome." In Cytokine Storm Syndrome, 197–207. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22094-5_12.

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2

"CYTOKINES AND CANCER." In Cytokines and Cytokine Receptors, 625–43. CRC Press, 2001. http://dx.doi.org/10.1201/9781482283716-31.

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3

"CYTOKINES IN HEMATOPOIESIS." In Cytokines and Cytokine Receptors, 69–98. CRC Press, 2001. http://dx.doi.org/10.1201/9781482283716-9.

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4

Cohen, S. B. A., J. Clayton, M. Londei, and M. Feldmann. "T cells and cytokines." In Cytokines, 179–96. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780199635672.003.0011.

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Abstract The functions of T cells and cytokines are intimately interlinked. It was not until T cell growth factors were defined and subsequently purified, and the cDNA encoding it cloned as ‘interleukin 2’ (1), that abundant non-malignant T cells could be cultured. The isolation of this and other T cell growth factors, now included in the broader category of cytokines, has permitted the development of long-term T cell-lines and clones. T cells can be isolated from normal healthy individuals or patients with disease, according to their antigen specificity and/or phenotype, and then perpetuated in long-term culture by cytokine stimulation. IL-2 is the major T cell cytokine used but certain subsets of T cells will proliferate in response to other cytokines, some independent of IL-2. For example IL-3 will stimulate most α β T cell receptor expressing CD4™cos−Tcells to proliferate, in man and mouse (2, 3).

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5

Schötze, Stefan, and Martin Kronke. "Measurement of cytokine induction of PC-specific phospholipase C and sphingomyelinases." In Cytokines, 93–110. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780199635672.003.0007.

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Abstract Cytokines play a vital role as mediators of intercellular communication within the immune system. One of the hallmarks of cytokine function is the marked redundancy of biological activities. The overlapping biological functions of TNF/IL-1 and GM-CSF/IL-3 are just two examples. The redundancy of cytokine activities may be based on the utilization of shared key components of intracellular signalling pathways. The principal architecture of major signalling pathways used by cytokines consists of series of proteins including G-proteins, second messenger generating enzymes, protein kinases, and phosphatases. Receptor-mediated hydrolysis of cellular phospholipids by phospholipases of distinct specificities (PLA2, PLC, PLD, SMase) is a ubiquitous event of central importance in cellular signalling. Activation of these enzymes results in generation of early second messenger molecules which further transduce receptor signals to cytoplasmic target proteins. Since multiple intracellular targets exist for a given second messenger, the cytokine signal may branch off to more complex and diversified signals.

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6

"CYTOKINES AND CYTOKINE MODULATORS." In Meyler's Side Effects of Drugs in Cancer and Immunology, 355–455. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-444-53267-1.50006-x.

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7

O'Shea, John J., Massimo Gadina, and Richard Siegel. "Cytokines and cytokine receptors." In Clinical Immunology, 108–35. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-7234-3691-1.00033-7.

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8

Mak, Tak W., and Mary E. Saunders. "Cytokines and Cytokine Receptors." In The Immune Response, 463–516. Elsevier, 2006. http://dx.doi.org/10.1016/b978-012088451-3.50019-3.

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9

O'shea, John, Cristina M. Tato, and Richard Siegel. "Cytokines and cytokine receptors." In Clinical Immunology, 139–71. Elsevier, 2008. http://dx.doi.org/10.1016/b978-0-323-04404-2.10010-7.

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10

O'Shea, John J., Massimo Gadina, and Richard M. Siegel. "Cytokines and Cytokine Receptors." In Clinical Immunology, 127–55. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-7020-6896-6.00009-0.

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Тези доповідей конференцій з теми "Cytokines"

1

Kimmel, Jeremy D., Morgan V. DiLeo, Isabella E. Valenti, Gregory A. Gibson, Simon C. Watkins, and William J. Federspiel. "Dynamics of Cytokine Capture Within Hemoadsorption Beads Used to Treat Sepsis." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204764.

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Sepsis is a serious medical condition characterized by systemic inflammation caused by infection, and affects more than 750,000 individuals per year in the US, with a mortality rate of approximately 30% [1]. The pathophysiology of sepsis is complex and not entirely understood, but is believed to be related to the dysfunction of multiple interdependent humoral mediator pathways, including redundant release of inflammatory cytokines [2]. Removal of both pro- and anti-inflammatory cytokines from the circulating blood is believed to be a promising therapy for severe sepsis [3]. We are developing an extracorporeal hemoadsorption device to remove cytokines from the blood using a novel, biocompatible, sorbent bead technology. A simple model was developed to characterize cytokine adsorption within hemoadsorption beads [4]. Despite rapid clearance of cytokines with hemoadsorption in an ex vivo murine sepsis model [5], our model analysis predicted that only the outer 20μm of each sorbent bead (avg diam = 450μm) adsorbed cytokine. In this work, we used in vitro column capture experiments and confocal laser scanning microscopy (CLSM) to examine cytokine adsorption dynamics within hemoadsorption beads.

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2

Pereira, Clayrton de Barros, Yuri Felix Pedra, and Renata Dellalibera-Joviliano. "Profile of IL-1 beta, INF-gamma, IL-4 and IL-17 in patients with COVID-19." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-175.

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The immune response to SARS-CoV-2 is mediated by several soluble chemotactic factors, including cytokines whose levels vary at different stages and types of infections. Clinical evidence shows that "cytokine storm," in which the body has high levels of several pro-inflammatory cytokines, is common in several patients with severe COVID-19. Thus, the aim of this study was to evaluate the inflammatory response mediated by the cytokines IL-1 Beta, INF-Gama, IL-4 and IL-17 in patients with COVID. Sandwich-type immunoenzymatic assays (ELISA sandwich) were performed to determine the serum cytokine concentration of a group of 11 patients with RT-PCR confirmed diagnoses compared to a control group (n=11). The samples were evaluated in duplicate and the statistical analyses of the results considered the measures of central tendency with the mean (Md). Thus, we found the results related to the different cytokines: IL-beta (patient = 138 pg/mL; control = 50 pg/mL); Interferon-gamma (patient= 104.25 pg/mL; control= 55 pg/mL); IL-4 (patient= 92.25 pg/mL; control 44 pg/mL); IL-17 (patient= 94.5 pg/mL; control 57 pg/mL). Understanding the variation in the levels of these mediators during pathology, through the analysis of the partial results of the project, is essential to elucidate the profile of the inflammatory response of patients with COVID-19.

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3

Jurišić, Vladimir. "POSSIBILITIES OF CYTOKINE DETERMINATION AND THEIR ANALYSIS IN VARIOUS TISSUES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.089j.

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Cytokines are small proteins that participate in many interactions between cells of the immune system as well as between many tissue cells including tumors. Currently, there is no universal classification of cytokines and they can be analyzed based on the cells that produce them or based on the type of activity. Cytokines have been studied for many years in medicine firstly in cancer patients in serum, but also in many other diseases including inflammation or other autoimmune diseases or other pathological conditions. Cytokines are still being discovered, and for many of them the structure, biological action and genes responsible for their regulation have already been determined. Bearing in mind that the development of technology has been developing enormously in the last period and those new methods of cytokine determination in various fluids and micro-concentrations are available to us. Here, the aim is to focus on the specific possibilities of determination and analysis of cytokine values in different tissues including cell culture supernatants, in individual cells as well as their genetic regulation. However, to understand their complex action in biological systems, including the pleiotropic effect of cytokines showing some time the overlap in the actions various models of analysis and interpretation of the obtained data are recommended today. This is especially complex and problematic in recent times of understanding the cytokine gene regulation and especially the possibility of their prediction. To resolve these problems, numerous databases have been created on the previously available experimental data, although their connection is not yet very clear. In addition, using integration of data, it is expected predict some models and systems in a specific situation, although it is still very difficult. So, aims are predict values in definitive situation and compare with some standards. Therefore, new methods of interpretation and new programs for analysis have been created. We expect that based on the new possibilities of analysis, better results will be achieved and that the role of these mediators for individual or personalized diagnosis or therapy in biomedicine will be determined.

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4

Plotnikova, E. M., I. A. Nesterova, and R. N. Nizamov. "STUDYING THE RESPONSE OF CELL CULTURES TO THE PRESENCE OF CYTOKINES IN THE NUTRITIONAL MEDIUM." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-2-7-10.

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Currently, a new generation of immunomodulators, cytokines, are widely used in medicine and veterinary medicine. Cytokines are active in very low concentrations, they regulate the proliferation and differentiation of cells of the immune system. Taking into account the high biological activity for cells of animal, plant and microbial origin in vivo and in vitro, we conducted the present studies, the purpose of which was to study the possibility of using cytokines as activators of the metabolism of animal cell cultures in vitro for the reproduction of viruses on them. In the experiments, cell cultures MDBK and BHK-21/13-02 obtained from the collection of cell cultures of the Federal State Budget Scientific Institution FSBSI «FCTRBS-ARRVI» were used. Nutrient media were used for growing cell cultures: Needle MEM, solution of Versen, trypsin, Hanks, bovine blood serum (BRS), fetal blood serum (FBMS). As activators of cell metabolism, commercial cytokines were used: IL-3, IL-6, colon-stimulating factor G-CSF produced by Cytokin LLC (St. Petersburg). Stimulating and inhibitory doses of cytokines were experimentally determined and added to media with cell cultures at the rate of 30 to 500 pg/cm3. It was found that among the tested classes of cytokines, interleukin-6 (IL-6) turned out to be the most active, which, when introduced into the growth medium at a concentration of 30-60 ng/cm3, had a metabolism-stimulating effect, providing a proliferation index of MDBK cells by 1.33 times and cell lines VNK-21/13-02 - 1.17 times, respectively.

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5

Kruglyakova, M. V., O. V. Smirnova, and N. M. Titova. "CHARACTERISTICS OF THE CYTOKINE PROFILE IN PHYSIOLOGICAL AND COMPLICATED PREGNANCY." In Культура, наука, образование: проблемы и перспективы. Нижневартовский государственный университет, 2021. http://dx.doi.org/10.36906/ksp-2021/79.

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One of the priority tasks of any state is to protect the health of mothers and children. Despite the great advances in diagnostics and methods for preventing the occurrence of pathologies during pregnancy, the percentage of normal births is decreasing every year. One of the most serious complications of pregnancy is preeclampsia, the prevalence of which in the world is increasing every year. This article presents data on the cytokine profile in preeclampsia. The properties and role of the main cytokines in physiological and complicated (preeclampsia) pregnancy, relative to the control group, are described. Using the methods of enzyme immunoassay and statistical analysis, we have shown the ratio of anti-inflammatory to pro-inflammatory cytokines in health and disease. The results of the study are presented as a median (25 quartile – 75 quartile).

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6

Kuzmina, L. P., A. G. Khotuleva, and M. M. Kolyaskina. "GENETIC POLYMORPHISM OF CYTOKINES FOR OCCUPATIONAL BRONCHO OBSTRUCTIVE DISEASES DEVELOPMENT RISK AND PROGNOSIS ASSESSMENT." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-265-268.

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One of the significant systems in the pathogenesis of lung diseases is the system of cytokines. Genetic polymorphism of cytokines can be associated with different levels of cytokine production when exposed to a stimulus of the same intensity in response to antigenic irritation, or tissue damage, which can determine individual sensitivity to chemicals. The purpose of this study was to evaluate the presence of associations of single nucleotide polymorphisms of cytokine genes with the development and severity of occupational bronchoobstructive diseases, taking into account the specifics of occupational factors. Materials and methods. Examined groups: COPD from exposure to welding aerosol (n=32), asthma from exposure to high-molecular allergens of organic origin (n=31), from exposure to low-molecular chemical allergens (n=37), from exposure to metal-allergens (n=68), group comparison — without lung diseases (n=200). Genotyping of polymorphisms TNF-α G308A, IL‑6 С174G, IL‑4 С589Т, IL‑10 G1082A was carried out. Results. The association of single nucleotide polymorphisms of the TNF-α gene with the development of occupational asthma from exposure to low-molecular chemical allergens (OR=2.043; 95% CI 1.050‑3.975), the association of IL‑10 gene with the development of COPD from exposure to welding aerosol (OR=2.653; 95% CI 1.211‑5.815) was determined, the IL‑6 gene — with the severity of asthma from exposure to low-molecular chemical allergens, the IL‑4 gene — with the severity of asthma from exposure to metal allergens. Conclusion. The differential informative value of the detection of single nucleotide polymorphisms of cytokine genes as risk markers for the development and severe course of bronchoobstructive diseases, depending on the specifics of occupational factors, was determined.

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Wang, Wei, Hamada A. Aboubakr, James Vang, Victor Brenk, Sagar M. Goyal, and James Collins. "Nanomagnetic Biosensor for the Detection of Porcine Interferon Gamma." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3375.

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Due to the anatomical and physiological similarities to humans that include similar heart size, flow rate, skin, liver enzymes and bone healing, porcine models as a powerful investigational platform have been widely used in research areas such as diabetes, obesity and islet transplantation [1]. The advantages of relative low cost, ease in handling and comparatively short period of breeding time may make swine provide a promising solution to the shortage of human donors and difficulty in isolating purified islets from adult human in future. Porcine cytokines play a significant role in innate immunity, apoptosis, angiogenesis, cell growth and differentiation. They are involved in cellular responses, maintenance of homeostasis, and disease states such as inflammatory disease, cardiovascular disease, and cancer. Thus, the technologies to analyze the expression of cytokines are developed rapidly and are still hot topics. The traditional approach for cytokine detection and quantification is the use of an enzyme-linked immunosorbent assay (ELISA). However, its inability to do multiplex test calls for more robust detection system. Biochip-based assay for the detection of biological agents using giant magnetoresistive (GMR) sensors and magnetic nanoparticles have emerged recently [2, 3]. It is proved that the nanomagnetic biosensor technology has advantages of low cost, high sensitivity, multiplexity, and real-time signal readout. The integration of GMR biosensor and use of weak magnetic fields allow to eventually realize point-of-care and portability. In addition, interferon gamma (IFNγ) is one of the most important porcine cytokines, and is associated with a number of autoinflammatory and autoimmune diseases. In this work, IFNγ is selected as a model target for the detection of porcine cytokine using nanomagnetic GMR biosensor.

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Maidhof, Robert, Neena Rajan, and Nadeen O. Chahine. "Effect of Inflammation on the Osmotic Response of Nucleus Pulposus Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80358.

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Intervertebral disc (IVD) degeneration is accompanied by elevated levels of pro-inflammatory cytokines, particularly IL-1β and TNF-α [1]. Disc cells from the nucleus pulposus (NPs) respond to cytokine stimulation with increased catabolic breakdown of the tissue, resulting in a positive feedback of disc integrity loss and further inflammation [2]. Previous studies by our group have examined the response of NP cells to Toll-Like Receptor-4 (TLR-4) activation through stimulation with lipopolysaccharide (LPS). TLR-4 is a pattern recognition receptor that is activated in innate immunity and by polysaccharide fragments from degenerated proteoglycans. TLR-4 activation by LPS results in stimulation of multiple cytokines by NP cells [3]. Moreover, we have shown that in vivo LPS injection results in catabolic changes in the IVD, including matrix breakdown, decrease in biomechanical properties and loss of disc height [4]. However, the specific cellular mechanisms for these catabolic changes remain to be elucidated.

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Ригер, Николай Александрович, Элеонора Николаевна Трушина, and Андрей Николаевич Тимонин. "INFLUENCE OF HIGH PHYSICAL LOADS ON THE IMMUNOREGULATORY STATUS OF ATHLETES." In Сборник избранных статей по материалам научных конференций ГНИИ "Нацразвитие" (Санкт-Петербург, Август 2022). Crossref, 2022. http://dx.doi.org/10.37539/aug304.2022.84.56.002.

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В статье приводятся данные изучения цитокинового профиля (определение уровней содержания интерлейкинов: IL-4, IL-10, IL-18 и γ-интерферона (γ-IFN) методом твердофазного иммуноферментного анализа у17 спортсменов - биатлонистов высшей спортивной квалификации и 17 здоровых добровольцев со средней физической активностью. Полученные результаты подтверждают значительную вариабельность содержания иммунорегуляторных цитокинов в сыворотке крови здоровых людей. Повышение уровней провоспалительных цитокинов у спортсменов свидетельствует о напряженности иммунного ответа при интенсивных физических нагрузках. The article presents the data of the study of the cytokine profile (determination of the levels of interleukins: IL-4, IL-10, IL-18 and γ-interferon (γ-IFN) by enzyme-linked immunosorbent assay in 17 athletes - biathletes of the highest sports qualification and 17 healthy volunteers with moderate physical activity. The results confirm significant variability in the content of immunoregulatory cytokines in the blood serum of healthy people. An increase in the levels of pro-inflammatory cytokines in athletes indicates the immunity tension during high-intensity exercise.

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Patterson, Karen, Beverly Franek, Nadera Sweiss, and Tim Niewold. "Serum Cytokines In Sarcoidosis." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5638.

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Звіти організацій з теми "Cytokines"

1

Xu, Guochao, and Xiaozhou Mao. The level of TH1 cytokines, TH2 cytokines and TH17 cytokines in patients with COVID-19 infection : A meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2023. http://dx.doi.org/10.37766/inplasy2023.8.0023.

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2

Mao, xiaozhou, sheng Zheng, and jiangyan Luo. Imbalance of TH 1 cytokines, TH 2 cytokines and associated cytokines in patients with chronic hepatitis B : A meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0034.

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3

Kurtzman, Scott H. Cytokines, Neovascularization and Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 1998. http://dx.doi.org/10.21236/ada371368.

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4

Kurtzman, Scott H. Cytokines, Neovascularization and Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 1998. http://dx.doi.org/10.21236/ada383239.

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5

Zeng, Yulin, Liwei Wang, Hai Zhou, and Yu Qi. Th1/Th2 cytokine profiles differentiating tuberculous from malignant pleural effusions: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0005.

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Review question / Objective: To clarify which one has a different predominance of Th1 and Th2 immune responses in malignant and tuberculous pleural effusions. We did a meta-analysis of the results published previously to assess the levels of Th1/Th2 cytokines in two types of pleural effusion and evaluated its ability to distinguish TPE from MPE. Condition being studied: Malignant and tuberculous pleural effusions are the two most common types of exudative pleural effusions, both of which can be seen with the typical accumulation of lymphocytes. Immune responses mediated by either the Th1 or Th2 subset dominate, depending on different types of pleural effusion. Thus, we performed a meta-analysis of all available studies to quantitatively evaluate the levels of Th1/Th2 cytokine profiles in TPE and MPE, as well as to assess the potential diagnostic value of these cytokines in discriminating TPE from MPE.

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Splitter, Gary, Zeev Trainin, and Yacov Brenner. Lymphocyte Response to Genetically Engineered Bovine Leukemia Virus Proteins in Persistently Lymphocytic Cattle from Israel and the U.S. United States Department of Agriculture, July 1995. http://dx.doi.org/10.32747/1995.7570556.bard.

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The goal of this proposal was to identify proteins of BLV recognized by lymphocyte subpopulations and determine the contribution of these proteins to viral pathogenesis. Our hypothesis was that BLV pathogenesis is governed by the T-cell response and that the immune system likely plays an important role in controlling the utcome of infection. Our studies presented in ths final report demonstrate that T cell competency declines with advancing stages of infection. Dramatic differences were observed in lymphocyte proliferation to recombinant proteins encoded by BLV gag (p12, p15, and p24) and env (gp30 and gp15) genes in different disease stages. Because retroviruses are known to mutate frequently, examinatin of infected cattle from both Israel and the United States will likely detect variability in the immune response. This combined research approach provides the first opportunity to selectively address the importance of T-cell proliferation to BLV proteins and cytokines produced during different stages of BLV infection. Lack of this information regarding BLV infection has hindered understanding lympocyte regulation of BLV pathogenesis. We have developed the essential reagents necessary to determine the prominence of different lymphocyte subpopulations and cytokines produced during the different disease stages within the natural host. We found that type 1 cytokines (IL-2 and IFN-g) increased in PBMCs from animals in early disease, and decreasd in PBMCs from animals in late disease stages of BLV infection, while IL-10, increased with disease progression. Recently, a dichotomy between IL-12 and IL-10 has emerged in regards to progression of a variety of diseases. IL-12 activates type 1 cytokine production and has an antagonistic effect on type 2 cytokines. Here, using quantitative competitive PCR, we show that peripheral blood mononuclear cells from bovine leukemia virus infected animals in the alymphocytotic disease stage express increased amount of IL-12 p40 mRNA. In contrast, IL-12 p40 mRNA expression by PL animals was significantly decreased compared to normal and alymphocytotic animals. To examine the functions of these cytokines on BLV expression, BLV tax and pol mRNA expression and p24 protein production were quantified by competitive PCR, and by immunoblotting, respectively. IL-10 inhibited BLV tax and pol mRNA expression by BLV-infected PBMCs. In addition, we determined that macrophages secret soluble factor(s) that activate BLV expression, and that secretion of the soluble factor(s) could be inhibited by IL-10. In contrast, IL-2 increased BLV tax and pol mRNA, and p24 protein production. These findings suggest that macrophages have a key role in regulating BLV expression, and IL-10 produced by BLV-infected animals in late disease stages may serve to control BLV expression, while IL-2 in the early stage of disease may activate BLV expression. PGE2 is an important immune regulator produced only by macrophages, and is known to facilitate HIV replication. We hypothesized that PGE2 may regulate BLV expression. Here, we show that cyclooxygenase-2 (COX-2) mRNA expression was decreased in PBMCs treated with IL-10, while IL-2 enhanced COX-2 mRNA expression. In contrast, addition of PGE2 stimulated BLV tax and pol mRNA expression. In addition, the specific COX-2 inhibitor, NS-398, inhibited BLV expression, while addition of PGE2 increased BLV tax expression regardless of NS-398. These findings suggest that macrophage derived cyclooxygenase -2 products, such as PGE2, may regulate virus expression and disease rogression in BLV infection, and that cytokines (IL-2 and IL-10) may regulate BLV expression through PGE2 production.

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Grimley, Phillip M. Use of Cytokines to Prevent Breast Cancer Growth and Progression. Fort Belvoir, VA: Defense Technical Information Center, August 1996. http://dx.doi.org/10.21236/ada325362.

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Bhowmick, Neil A. Regulation and Function of Cytokines that Predict Prostate Cancer Metastasis. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada569356.

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9

Grimley, Philip M. Use of Cytokines to Prevent Breast Cancer Growth and Progression. Fort Belvoir, VA: Defense Technical Information Center, August 1997. http://dx.doi.org/10.21236/ada339111.

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10

Bhowmick, Neil A. Regulation and Function of Cytokines That Predict Prostate Cancer Metastasis. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada590468.

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