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Статті в журналах з теми "CRISPR spacers"
Horvath, Philippe, Dennis A. Romero, Anne-Claire Coûté-Monvoisin, Melissa Richards, Hélène Deveau, Sylvain Moineau, Patrick Boyaval, Christophe Fremaux, and Rodolphe Barrangou. "Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus." Journal of Bacteriology 190, no. 4 (December 7, 2007): 1401–12. http://dx.doi.org/10.1128/jb.01415-07.
Повний текст джерелаToro, Magaly, Guojie Cao, Wenting Ju, Marc Allard, Rodolphe Barrangou, Shaohua Zhao, Eric Brown, and Jianghong Meng. "Association of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Elements with Specific Serotypes and Virulence Potential of Shiga Toxin-Producing Escherichia coli." Applied and Environmental Microbiology 80, no. 4 (December 13, 2013): 1411–20. http://dx.doi.org/10.1128/aem.03018-13.
Повний текст джерелаAchigar, Rodrigo, Martina Scarrone, Geneviève M. Rousseau, Cécile Philippe, Felipe Machado, Valentina Duvós, María Pía Campot, et al. "Ectopic Spacer Acquisition in Streptococcus thermophilus CRISPR3 Array." Microorganisms 9, no. 3 (March 1, 2021): 512. http://dx.doi.org/10.3390/microorganisms9030512.
Повний текст джерелаvan der Ploeg, Jan R. "Analysis of CRISPR in Streptococcus mutans suggests frequent occurrence of acquired immunity against infection by M102-like bacteriophages." Microbiology 155, no. 6 (June 1, 2009): 1966–76. http://dx.doi.org/10.1099/mic.0.027508-0.
Повний текст джерелаSerbanescu, M. A., M. Cordova, K. Krastel, R. Flick, N. Beloglazova, A. Latos, A. F. Yakunin, D. B. Senadheera, and D. G. Cvitkovitch. "Role of the Streptococcus mutans CRISPR-Cas Systems in Immunity and Cell Physiology." Journal of Bacteriology 197, no. 4 (December 8, 2014): 749–61. http://dx.doi.org/10.1128/jb.02333-14.
Повний текст джерелаPavlova, Yekaterina S., David Paez-Espino, Andrew Yu Morozov, and Ilya S. Belalov. "Searching for fat tails in CRISPR-Cas systems: Data analysis and mathematical modeling." PLOS Computational Biology 17, no. 3 (March 26, 2021): e1008841. http://dx.doi.org/10.1371/journal.pcbi.1008841.
Повний текст джерелаDeveau, Hélène, Rodolphe Barrangou, Josiane E. Garneau, Jessica Labonté, Christophe Fremaux, Patrick Boyaval, Dennis A. Romero, Philippe Horvath, and Sylvain Moineau. "Phage Response to CRISPR-Encoded Resistance in Streptococcus thermophilus." Journal of Bacteriology 190, no. 4 (December 7, 2007): 1390–400. http://dx.doi.org/10.1128/jb.01412-07.
Повний текст джерелаBolotin, Alexander, Benoit Quinquis, Alexei Sorokin, and S. Dusko Ehrlich. "Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin." Microbiology 151, no. 8 (August 1, 2005): 2551–61. http://dx.doi.org/10.1099/mic.0.28048-0.
Повний текст джерелаHeussler, Gary E., Jon L. Miller, Courtney E. Price, Alan J. Collins, and George A. O'Toole. "Requirements for Pseudomonas aeruginosa Type I-F CRISPR-Cas Adaptation Determined Using a Biofilm Enrichment Assay." Journal of Bacteriology 198, no. 22 (August 29, 2016): 3080–90. http://dx.doi.org/10.1128/jb.00458-16.
Повний текст джерелаLopatina, Anna, Sofia Medvedeva, Daria Artamonova, Matvey Kolesnik, Vasily Sitnik, Yaroslav Ispolatov, and Konstantin Severinov. "Natural diversity of CRISPR spacers of Thermus : evidence of local spacer acquisition and global spacer exchange." Philosophical Transactions of the Royal Society B: Biological Sciences 374, no. 1772 (March 25, 2019): 20180092. http://dx.doi.org/10.1098/rstb.2018.0092.
Повний текст джерелаДисертації з теми "CRISPR spacers"
Medvedeva, Sofia. "Natural Diversity of CRISPR Spacers." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS538.
Повний текст джерелаCRISPR-Cas is a prokaryotic immunity system against mobile genetic elements, such as viruses and plasmids. The system consists of two components: the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas). In the CRISPR array, short fragments of foreign DNA, called spacers, are interleaved with palindromic repeats. During the adaptation stage of the CRISPR-Cas immunity, new spacers are inserted into the CRISPR array, whereas during the expression and interference stages, spacers are transcribed, processed and complexed with Cas proteins to target the complementary foreign DNA or RNA molecules for degradation. Analysis of CRISPR spacers is a valuable source of information about virus-host interactions, particularly powerful when applied to metagenomic data. In this work, we explored the diversity of CRISPR spacers in different natural prokaryotic communities, including extinct Escherichia coli community from a mammoth intestine, Flavobacterium communities from Antarctic surface snow, Thermus communities from four distant hot springs in Italy and Chile, and Sulfolobales community from a Japanese thermal field. The comparison of obtained environmental spacer sets with each other and with spacers from public databases as well as with sequences of viruses allowed us to reach several non-trivial conclusions and to gain insights into virus-host and virus-virus interactions in natural microbial communities
Vyhovskyi, Danylo. "In vivo studies of CRISPR adaptation mechanism and specificity." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS729.
Повний текст джерелаThis thesis investigates the mechanisms of the CRISPR-Cas adaptive immunity in prokaryotes, primarily using the type I-E system in Escherichia coli, focusing on the spacer acquisition process and the system's specificity. It sheds light on the dynamics of spacers generation and integration into CRISPR arrays, comparing naive and primed adaptation modes. The study reveals that a particular PAM (protospacer adjacent motif) - proximal sequence impedes spacer acquisition in the primed mode, providing a distinct identifier for naturally acquired spacers. The study further reveals the role of non-Cas enzymes, linked to DNA repair pathways, in spacer generation and processing, contributing to CRISPR adaptation and interference.Another course of the study identifies potential hazards posed by off-target effects caused by Cas9 (dCas9) RNA-guided enzyme that can inadvertently silence genes. This occurs when there's a minimal match of just four nucleotides between the gRNA and the target within the PAM-proximal sequence, emphasizing the need for careful experimental design in CRISPR-Cas research.Overall, the thesis expands understanding of the complex molecular mechanisms behind CRISPR adaptation, highlighting the role of non-Cas proteins and the significance of a specific genetic context of seed sequences, leading to the development of more precise and efficient genetic engineering tools
Jacot-Guillarmod, Paul. "Sobriety of crisp and fuzzy topological spaces." Thesis, Rhodes University, 2004. http://hdl.handle.net/10962/d1005228.
Повний текст джерелаStens, Cassandra, Isabella Enoksson, and Sara Berggren. "The CRISPR-Cas system." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171997.
Повний текст джерелаWong, Shi Pey. "Analysis of the adaptation mechanism in the type II-A CRISPR-Cas system." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19806.
Повний текст джерелаThe RNA guided adaptive immune system CRISPR (clustered regularly interspaced short palindromic repeats) Cas (CRISPR-associated) immunizes prokaryotic cells against mobile genetic elements (MGEs). During spacer acquisition stage, a short nucleic acid sequence (prespacer) is acquired from the MGEs, processed and finally integrated into the CRISPR array as a spacer, which serves as genetic memory to defend against the invasion of the cognate MGEs. The molecular mechanism for the spacer acquisition of the type II A systems, which encode cas9, cas1, cas2, csn2 and tracrRNA, is still not fully understood. Therefore, we investigated the requirement of the different Cas proteins for spacer acquisition. We verified the acquisition activity of the type II A systems of Streptococcus thermophilus LMD 9 via spacer acquisition studies by phage challenge. We observed higher acquisition rates in the CRISPR3 locus compared to the CRISPR1 locus. Our plasmid-based spacer acquisition study confirmed in addition to Cas1, Cas2 and Csn2 the requirement of Cas9 for spacer acquisition. Yeast two hybrid and pull down approaches revealed specific interactions among the Cas proteins, as well as interactions between Cas and DNA repair proteins. The interaction regions of Cas1 with Cas9 were identified by SPOT peptide assay. Altogether, our study suggests that Cas proteins interact with proteins within and beyond the CRISPR Cas systems, and it provides a basis for the investigation of the potential roles of DNA repair proteins in the CRISPR Cas systems and/or vice versa.
Hille, Frank [Verfasser]. "Investigation of Spacer Acquisition Mechanisms in Type V-A CRISPR-Cas Systems / Frank Hille." Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1215570341/34.
Повний текст джерелаRibeiro, Mateus Cotta. "A reprodução crítica do espaço na porção meridional da Serra do Espinhaço de Minas Gerais: modernização do espaço e crise da sociedade do trabalho." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/8/8136/tde-15012016-135253/.
Повний текст джерелаThis study deals with the social changes experienced by people from the southern area of Serra do Espinhaço, Minas Gerais, Brazil. These changes are related to the increase of the tourism industry however they are determined by crise o work society reproduction.
Cruz, Murilo Medici Navarro da. "Estado, espaço e acumulação na crise contemporânea." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/8/8136/tde-20062007-153251/.
Повний текст джерелаThis work starts from a matter put by the current reality: The world economic crisis, specially seem on what has been denominated \"money predomination economy\" and, along with the crisis, the one of national State, both seen under the world\'s perspective and, equally, the Brazilian perspective. Nevertheless, this work does not intend, herein, to give a historical or purely economic treatment of the problem. Instead, what you will see is closer to an analytical and theoretical exercise. This work constitutes, firstly, of a deep discussion about the basis of capital economy which, according to what is understood, also are the basis of the current economic crisis. Secondly, to reflect about the economic crisis as much as politics, is necessary to reflect about the production of space and the State\'s role within the capitalist society. And thirdly, the union between the State and the capital shows itself identifiable on the national territory analysis along with your basis. Last but not least, the current crisis problem is put through a criticism to the lack of focusing the capital on a specific market, criticism that takes us to formulate the hypothesis of an abstract investment of capital, which would be a characteristic of the crisis itself.
Philipp, Carolin [Verfasser]. "Spaces of Resistance – Framing Crisis and Activism in Athens / Carolin Philipp." Kassel : Universitätsbibliothek Kassel, 2018. http://d-nb.info/1155948718/34.
Повний текст джерелаKreston, Nicholas Alexander. "Post-Keynesian financial spaces, places, and flows : geographies of finance and financial crisis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3ea77af2-650c-456a-a4c2-5ee67c83d293.
Повний текст джерелаКниги з теми "CRISPR spacers"
Martin, David. Crisis in space. New York: Ballantine Books, 1986.
Знайти повний текст джерелаCorporation, British Broadcasting, ed. Crisis in space. London: Severn House by arrangement with the British Broadcasting Corporation, 1986.
Знайти повний текст джерелаHolt, Michael. Crisis in space. New York: Ballantine Books, 1986.
Знайти повний текст джерелаill, Kinsella Pat, ed. Crisis. Minneapolis, MN: Magic Wagon, 2017.
Знайти повний текст джерелаNansen, Ralph. Energy crisis: Solution from space. Burlington, Ont: Apogee Books, 2009.
Знайти повний текст джерелаReis, Ronald A. Apollo 13: Crisis in space. New York: Chelsea House, 2012.
Знайти повний текст джерелаVitalidad y crisis en los espacios públicos de Sevilla. [Seville]: Diputación de Sevilla, 2006.
Знайти повний текст джерелаCabannes, Yves, Mike Douglass, and Rita Padawangi, eds. Cities in Asia by and for the People. NL Amsterdam: Amsterdam University Press, 2018. http://dx.doi.org/10.5117/9789462985223.
Повний текст джерелаMaking Humanitarian Spaces Global: Coordinating Crisis Response through the Cluster Approach. [New York, N.Y.?]: [publisher not identified], 2012.
Знайти повний текст джерелаBouma, Geiske. Ruimtelijke ordening in crisis: Bijdragen aan de PlanDag 2010. Delft]: [Stichting Planologische Discussiedagen], 2010.
Знайти повний текст джерелаЧастини книг з теми "CRISPR spacers"
Davison, Michelle, and Devaki Bhaya. "Creation and Analysis of a Virome: Using CRISPR Spacers." In Methods in Molecular Biology, 307–16. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9_20.
Повний текст джерелаDupuis, Marie-Ève, Rodolphe Barrangou, and Sylvain Moineau. "Procedures for Generating CRISPR Mutants with Novel Spacers Acquired from Viruses or Plasmids." In Methods in Molecular Biology, 195–222. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9_13.
Повний текст джерелаPallarés, Ana Morcillo. "Crisis and opportunity." In Manhattan's Public Spaces, 61–69. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003198543-4.
Повний текст джерелаMokrousov, Igor, and Nalin Rastogi. "Spacer-Based Macroarrays for CRISPR Genotyping." In Methods in Molecular Biology, 111–31. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9_7.
Повний текст джерелаBurman, Erica. "Lockdown Vistas: Time, Space, Solidarity, Action." In The Psychology of Global Crises and Crisis Politics, 189–212. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76939-0_9.
Повний текст джерелаJones, Martin, and Kevin Ward. "Excavating the Logic of British Urban Policy: Neoliberalism as the “Crisis of Crisis-Management”." In Spaces of Neoliberalism, 126–47. Chichester, UK: John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781444397499.ch6.
Повний текст джерелаPallarés, Ana Morcillo. "Identity crisis: Lincoln Center and the High Line." In Manhattan's Public Spaces, 144–69. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003198543-9.
Повний текст джерелаMartín-Moruno, Dolores. "Crisis? What Crisis? Making Humanitarian Crises Visible in the History of Emotions." In Making Humanitarian Crises, 1–28. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-00824-5_1.
Повний текст джерелаGouw, Arvin M. "CRISPR Challenges and Opportunities for Space Travel." In Human Enhancements for Space Missions, 19–34. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42036-9_2.
Повний текст джерелаMaciocco, Giovanni, and Silvano Tagliagambe. "The Aesthetic Crisis as the Crisis of the Glance." In People and Space, 13–18. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9879-6_3.
Повний текст джерелаТези доповідей конференцій з теми "CRISPR spacers"
Timkin, P. D., and A. A. Penzin. "An experimental approach for diagnosing cercosporosis using RPA+CRISPR/Cas12a." In II All-Russian (national) scientific conference with international participation "Russian Science, Innovation, Education". Krasnoyarsk Science and Technology City Hall, 2023. http://dx.doi.org/10.47813/rosnio-ii.2023.8.263-266.
Повний текст джерелаPernak, Elizaveta, Mariia Vladimirova, Viktoria Muntyan, Alexey Afonin, and Marina Roumiantseva. "ANALYSIS OF CRISPR CASSETTE ELEMENTS IN NATIVE ISOLATES OF SINORHIZOBIUM MELILOTI ISOLATED IN THE CENTRAL ASIAN ORIGIN OF PLANT DIVERSITY." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023/6.1/s25.13.
Повний текст джерелаMuhlbauer, Rachel L., Kristen Turner, Finn Hiatt, Robert Dyer, Jeff Slostad, and Robert P. Hoyt. "CRISSP: Customizable, Recyclable Launch Packaging." In AIAA SPACE 2016. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2016. http://dx.doi.org/10.2514/6.2016-5243.
Повний текст джерелаTsafoulia, Loukia, and Severino Alfonso. "Transient Spaces: Building Community in Crisis Contexts." In 2018 ACSA International Conference. ACSA Press, 2018. http://dx.doi.org/10.35483/acsa.intl.2018.1.
Повний текст джерелаBaryshev, Yurij. "Physics of Gravitational Interaction: Geometry of Space or Quantum Field in Space." In 1st CRISIS IN COSMOLOGY CONFERENCE, CCC-1. AIP, 2006. http://dx.doi.org/10.1063/1.2189130.
Повний текст джерелаWu, Wei-Zhi, and You-Hong Xu. "Rough approximations of intuitionistic fuzzy sets in crisp approximation spaces." In 2010 Seventh International Conference on Fuzzy Systems and Knowledge Discovery (FSKD). IEEE, 2010. http://dx.doi.org/10.1109/fskd.2010.5569662.
Повний текст джерелаStranix, Katie. "Building Resiliency Through Small Scale Restorative Spaces." In 2022 AIA/ACSA Intersections Research Conference. ACSA Press, 2022. http://dx.doi.org/10.35483/acsa.aia.inter.22.12.
Повний текст джерелаTsafoulia, Loukia. "Transient Spaces: Building Community in Crisis Contexts Project." In 2018 ACSA International Conference. ACSA Press, 2018. http://dx.doi.org/10.35483/acsa.intl.2018.2.
Повний текст джерелаBachtarzi, Rym Mouni, Djamel Alkama, and Hana Salah-Salah. "Urban Public Space in The Context of a New Era, Case of Annaba City-Algeria." In 4th International Conference of Contemporary Affairs in Architecture and Urbanism – Full book proceedings of ICCAUA2020, 20-21 May 2021. Alanya Hamdullah Emin Paşa University, 2021. http://dx.doi.org/10.38027/iccaua2021199n3.
Повний текст джерелаLasmane, Skaidrīte. "Including the Emotional Potential of Literature in Post-crisis Education." In 80th International Scientific Conference of the University of Latvia. University of Latvia Press, 2022. http://dx.doi.org/10.22364/htqe.2022.73.
Повний текст джерелаЗвіти організацій з теми "CRISPR spacers"
Castilleja Vargas, Liliana, Daniel Hernaiz, Alejandro Rasteletti, and Eduardo Borensztein. International Crises and Policy Responses in the Southern Cone. Inter-American Development Bank, October 2012. http://dx.doi.org/10.18235/0011434.
Повний текст джерелаMolloy, James P. Air and Space Expeditionary Force Crisis Action Leadership for Commanders. Fort Belvoir, VA: Defense Technical Information Center, April 2004. http://dx.doi.org/10.21236/ada434089.
Повний текст джерелаCuerden, Richard, Mary Williams, Jeanne Breen, Dan Campsal, Suzy Charman, David G. Davies, Nick Reed, and Sarah Simpson. Safe Roads for All. TRL, August 2021. http://dx.doi.org/10.58446/ohss3066.
Повний текст джерелаRebucci, Alessandro, Andrew Powell, and Eduardo Fernández-Arias. The Multilateral Response to the Global Crisis: Rationale, Modalities, and Feasibility. Inter-American Development Bank, June 2009. http://dx.doi.org/10.18235/0010916.
Повний текст джерелаRomer, Christina, and David Romer. Fiscal Space and the Aftermath of Financial Crises: How It Matters and Why. Cambridge, MA: National Bureau of Economic Research, April 2019. http://dx.doi.org/10.3386/w25768.
Повний текст джерелаAbed, Dana, Rihab Sawaya, and Nadim Tabbal. Analyzing Voter Turnout in Lebanon: Political Change in Times of Crisis. Oxfam, April 2022. http://dx.doi.org/10.21201/2022.8823.
Повний текст джерелаSobhy, Hania. Reforms for Another Planet: The Global Learning Crisis, Political Drivers and Expert Views on Egypt’s Edu 2.0. Research on Improving Systems of Education (RISE), February 2023. http://dx.doi.org/10.35489/bsg-rise-2023/pe06.
Повний текст джерелаTrapani, Paola. Collaborative Housing as a Response to the Housing Crisis in Auckland. Unitec ePress, July 2018. http://dx.doi.org/10.34074/ocds.0821.
Повний текст джерелаMontiel, Peter J., and Eduardo Fernández-Arias. Crisis Response in Latin America: Is the "Rainy Day" at Hand? Inter-American Development Bank, June 2009. http://dx.doi.org/10.18235/0010915.
Повний текст джерелаBonomo, Marco, Claudio R. Frischtak, and Paulo Ribeiro. Public Investment and Fiscal Crisis in Brazil: Finding Culprits and Solutions. Inter-American Development Bank, April 2021. http://dx.doi.org/10.18235/0003199.
Повний текст джерела