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Добірка наукової літератури з теми "CPDP"

Автор: Grafiati

Опубліковано: 11 вересня 2023

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Статті в журналах з теми "CPDP"

Parthiban, Gunasingham, Ramachandren Dushanan, Samantha Weerasinghe, Dhammike Dissanayake, and Rajendram Senthilnithy. "Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies." Indonesian Journal of Chemistry 22, no. 6 (November 25, 2022): 1534. http://dx.doi.org/10.22146/ijc.74167.

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The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT). HDACs are thought to be vital for cell function. Particularly, higher HDAC expression is frequent in various cancers, resulting in the dysregulation of several target genes involved in cell proliferation, differentiation, and survival. In this study, the inhibitory feasibility of several HDAC inhibitors was investigated, including vorinostat (SAHA), N-hydroxy-3-phenylprop-2-enamide (CPD1), N-hydroxy-3-(pyridine-4-yl)prop-2-enamide (CPD2), N-hydroxy-3-(pyridine-2-yl)prop-2-enamide (CPD3), 4-(diphenylamino)-N-(5-(hydroxyamino)-5-oxopentyl)benzamide (CPD4), 2-(6-(((6-fluoronaphthalen-2-yl)methyl)amino)-3-azabicyclo[3.1.0]hex-3-yl)-N-hydroxypirimidine-5-carboxamide (CPD5), and N-(3-aminopropyl)-N-hydroxy-2-((naphthalene-1-yloxy)methyl)oct-2-enediamide (CPD6). By examining the stability of the enzyme, positional stability of the individual amino acids, and binding energies of HDLP-inhibitor complexes, the inhibitory feasibility was assessed. The complexes of the HDLP enzyme with SAHA, CPD4, CPD5, and CPD6 had higher stability than the other studied complexes, according to the results of trajectory analysis and the Ramachandran plot. Based on the calculated MM-PBSA binding free energies, the stability of the HDLP enzyme followed this order CPD4 > CPD5 > SAHA > CPD6 > CPD2 > CPD3 > CPD1. The drugability values followed the same trend as the previous ones. Based on the obtained in silico results, CPD4, CPD5, and CPD6 were discovered to be possible lead compounds as reference inhibitors of SAHA.

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Zhong, Yiwen, Kun Song, ShengKai Lv, and Peng He. "An Empirical Study of Software Metrics Diversity for Cross-Project Defect Prediction." Mathematical Problems in Engineering 2021 (November 28, 2021): 1–11. http://dx.doi.org/10.1155/2021/3135702.

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Cross-project defect prediction (CPDP) is a mainstream method estimating the most defect-prone components of software with limited historical data. Several studies investigate how software metrics are used and how modeling techniques influence prediction performance. However, the software’s metrics diversity impact on the predictor remains unclear. Thus, this paper aims to assess the impact of various metric sets on CPDP and investigate the feasibility of CPDP with hybrid metrics. Based on four software metrics types, we investigate the impact of various metric sets on CPDP in terms of F-measure and statistical methods. Then, we validate the dominant performance of CPDP with hybrid metrics. Finally, we further verify the CPDP-OSS feasibility built with three types of metrics (orient-object, semantic, and structural metrics) and challenge them against two current models. The experimental results suggest that the impact of different metric sets on the performance of CPDP is significantly distinct, with semantic and structural metrics performing better. Additionally, trials indicate that it is helpful for CPDP to increase the software’s metrics diversity appropriately, as the CPDP-OSS improvement is up to 53.8%. Finally, compared with two baseline methods, TCA+ and TDSelector, the optimized CPDP model is viable in practice, and the improvement rate is up to 50.6% and 25.7%, respectively.

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Toshchakov, Vladimir Y., and Artur Javmen. "Targeting the TLR signalosome with TIR domain-derived cell-permeable decoy peptides: the current state and perspectives." Innate Immunity 26, no. 1 (January 2020): 35–47. http://dx.doi.org/10.1177/1753425919844310.

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The ability to engineer pharmaceuticals that target the signal-dependent interactions of signaling proteins should revolutionize drug development. One approach to the rational design of protein interaction inhibitors uses decoy peptides, i.e. segments of protein primary sequence, which are derived from interfaces that mediate functional protein interactions. Decoy peptides often retain the ability of the full-length prototype to bind the docking site of the folded protein and thereby block the signal transduction. This review summarizes advances made in the last decade in the development of cell-permeable decoy peptide (CPDP) inhibitors to target the Toll/IL-1R resistance (TIR) domain-mediated protein interactions in TLR signaling, in connection with the recent progress in understanding of the TLR signalosome assembly mechanisms. We present a large collection of currently available, TIR-targeting CPDPs and propose their classification based on the types of TIR–TIR interactions they target. The binding behavior of different CPDP-TIR pairs, studied in cell-based assays and in binary in vitro systems using recombinant TIR domains, is also reviewed. The available affinity data provide benchmarks for rapid preliminary evaluation of future inhibitors. We review literature that evaluates the in vivo potency of select CPDPs and attempt to outline the areas of forthcoming progress, towards the development of CPDP-based TLR inhibitors of pharmaceutical grade.

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You, Guoan, Feng Wang, and Yutao Ma. "An Empirical Study of Ranking-Oriented Cross-Project Software Defect Prediction." International Journal of Software Engineering and Knowledge Engineering 26, no. 09n10 (November 2016): 1511–38. http://dx.doi.org/10.1142/s0218194016400155.

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Cross-project defect prediction (CPDP) has recently become very popular in the field of software defect prediction. It was generally treated as a binary classification problem or a regression problem in most of previous studies. However, these existing CPDP methods may be not suitable for those software projects that have limited manpower and budget. To address the issue of priority estimation for buggy software entities, in this paper CPDP is formulated as a ranking problem. Inspired by the idea of the pointwise approach to learning to rank, we propose a ranking-oriented CPDP approach called ROCPDP. A case study conducted on the datasets collected from AEEEM and PROMISE shows that ROCPDP outperforms the eight baseline methods in two CPDP scenarios, namely one-to-one and many-to-one. Besides, in the many-to-one scenario ROCPDP is, by and large, comparable to the best baseline method performed in a specific within-project defect prediction scenario.

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Qiu, Shaojian, Hao Xu, Jiehan Deng, Siyu Jiang, and Lu Lu. "Transfer Convolutional Neural Network for Cross-Project Defect Prediction." Applied Sciences 9, no. 13 (June 29, 2019): 2660. http://dx.doi.org/10.3390/app9132660.

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Cross-project defect prediction (CPDP) is a practical solution that allows software defect prediction (SDP) to be used earlier in the software lifecycle. With the CPDP technique, the software defect predictor trained by labeled data of mature projects can be applied for the prediction task of a new project. Most previous CPDP approaches ignored the semantic information in the source code, and existing semantic-feature-based SDP methods do not take into account the data distribution divergence between projects. These limitations may weaken defect prediction performance. To solve these problems, we propose a novel approach, the transfer convolutional neural network (TCNN), to mine the transferable semantic (deep-learning (DL)-generated) features for CPDP tasks. Specifically, our approach first parses the source file into integer vectors as the network inputs. Next, to obtain the TCNN model, a matching layer is added into convolutional neural network where the hidden representations of the source and target project-specific data are embedded into a reproducing kernel Hilbert space for distribution matching. By simultaneously minimizing classification error and distribution divergence between projects, the constructed TCNN could extract the transferable DL-generated features. Finally, without losing the information contained in handcrafted features, we combine them with transferable DL-generated features to form the joint features for CPDP performing. Experiments based on 10 benchmark projects (with 90 pairs of CPDP tasks) showed that the proposed TCNN method is superior to the reference methods.

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Luo, Shajie, Fajian Ren, Jiangang Dai, Yan Chen, and Zhongzhu Yang. "Novel poly(arylene ether nitrile) containing pendant aliphtatic ring in the chain: Synthesis and properties." High Performance Polymers 34, no. 2 (November 1, 2021): 221–31. http://dx.doi.org/10.1177/09540083211042267.

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Two kinds of novel poly(arylene ether nitrile)s (CPDP-DCBN and CHDP-DCBN) containing pendant aliphtatic ring were synthesized by 4,4′-cyclopentane-1,1′-diyldiphenol (CPDP) or 4,4′-cyclohexane-1,1′-diyldiphenol (CHDP) and 2,6-dichlorobenzonitrile (DCBN) in this work. The inherent viscosities of poly(arylene ether nitrile)s (PENs) were in the range of 0.701–0.806 dL g−1. The polymers showed high glass transition temperatures ( T g) of 185.4–196.4°C and weight-loss temperatures ( T5%) of 447.8–454.3°C. The obtained CPDP-DCBN and CHDP-DCBN could be hot pressed into the films, which showed the tensile strengths of 82.6 MPa and 86.8 MPa, respectively. And the storage modulus of CPDP-DCBN and CHDP-DCBN were about 1.0 GPa and 1.5 GPa at 150°C, respectively. Additionally, the PENs could be dissolved in many solutions at room temperature, such as NMP and concentrated H2SO4, indicating that they had good solubility; they can be processed by the solution method. Meanwhile, the optical transmittance of CPDP-DCBN was 78.1% at 450 nm; it has potential to be applied to the heat-resistant optical film.

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Xing, Ying, Wanting Lin, Xueyan Lin, Bin Yang, and Zhou Tan. "Cross-Project Defect Prediction Based on Two-Phase Feature Importance Amplification." Computational Intelligence and Neuroscience 2022 (April 18, 2022): 1–14. http://dx.doi.org/10.1155/2022/2320447.

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As the typical application of computational intelligence in software engineering, cross-project defect prediction (CPDP) uses labeled data from other projects (source projects) for building models to predict the defects in the current projects (target projects), helping testers quickly locate the defective modules. But class imbalance and different data distribution among projects make CPDP a challenging topic. To address the above two problems, we propose a two-phase feature importance amplification (TFIA) CPDP model in this paper which can solve these two problems from domain adaptation phase and classification phase. In the domain adaptation phase, the differences in data distribution among projects are reduced by filtering both source and target projects, and the correlation-based feature selection with greedy best-first search amplifies the importance of features with strong feature-class correlation. In the classification phase, Random Forest works as the classifier to further amplify the importance of highly correlated features and establish a model which is sensitive to highly correlated features. We conducted both ablation experiments and comparison experiments on the widely used AEEEM database. Experimental results show that TFIA can yield significant improvement on CPDP. And the performance of TFIA CPDP model in all experiments is stable and efficient, which lays a solid foundation for its further application in practical engineering.

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Norouz Dizaji, Araz, Matin Yazdani Kohneshahri, Sena Gafil, Muhammed Tilahun Muhammed, Tulin Ozkan, Ilyas Inci, Cengiz Uzun, and Esin Aki Yalcin. "Fluorescence labelled XT5 modified nano-capsules enable highly sensitive myeloma cells detection." Nanotechnology 33, no. 26 (April 8, 2022): 265101. http://dx.doi.org/10.1088/1361-6528/ac60dc.

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Abstract Accurate diagnosis of cancer cells in early stages plays an important role in reliable therapeutic strategies. In this study, we aimed to develop fluorescence-conjugated polymer carrying nanocapsules (NCs) which is highly selective for myeloma cancer cells. To gain specific targeting properties, NCs, XT5 molecules (a benzamide derivative) which shows high affinity properties against protease-activated receptor-1 (PAR1), that overexpressed in myeloma cancer cells, was used. For this purpose, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]-carboxylic acid (DSPE-PEG2000-COOH) molecules, as a main encapsulation material, was conjugated to XT5 molecules due to esterification reaction using N,N′-dicyclohexylcarbodiimide as a coupling agent. The synthesized DSPE-PEG2000-COO-XT5 was characterized by using FT-IR and 1H NMR spectroscopies and results indicated that XT5 molecules were successfully conjugated to DSPE-PEG2000-COOH. Poly(fluorene-alt-benzothiadiazole) (PFBT) conjugated polymer (CP) was encapsulated with DSPE-PEG2000-COO-XT5 due to dissolving in tetrahydrofuran and ultra-sonication in an aqueous solution, respectively. The morphological properties, UV–vis absorbance, and emission properties of obtained CP encapsulated DSPE-PEG2000−COO-XT5 (CPDP-XT5) NCs was determined by utilizing scanning electron microscopy, UV–vis spectroscopy, and fluorescent spectroscopy, respectively. Cytotoxicity properties of CPDP-XT5 was evaluated by performing MTT assay on RPMI 8226 myeloma cell lines. Cell viability results confirmed that XT5 molecules were successfully conjugated to DSPE-PEG2000-COOH. Specific targeting properties of CPDP-XT5 NCs and XT5-free NCs (CPDP NCs) were investigated on RPMI 8226 myeloma cell lines by utilizing fluorescent microscopy and results indicated that CPDP-XT5 NCs shows significantly high affinity in comparison to CPDP NCs against the cells. Homology modeling and molecular docking properties of XT5 molecules were evaluated and simulation results confirmed our results.

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Qiu, Shaojian, Lu Lu, Siyu Jiang, and Yang Guo. "An Investigation of Imbalanced Ensemble Learning Methods for Cross-Project Defect Prediction." International Journal of Pattern Recognition and Artificial Intelligence 33, no. 12 (November 2019): 1959037. http://dx.doi.org/10.1142/s0218001419590377.

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Machine-learning-based software defect prediction (SDP) methods are receiving great attention from the researchers of intelligent software engineering. Most existing SDP methods are performed under a within-project setting. However, there usually is little to no within-project training data to learn an available supervised prediction model for a new SDP task. Therefore, cross-project defect prediction (CPDP), which uses labeled data of source projects to learn a defect predictor for a target project, was proposed as a practical SDP solution. In real CPDP tasks, the class imbalance problem is ubiquitous and has a great impact on performance of the CPDP models. Unlike previous studies that focus on subsampling and individual methods, this study investigated 15 imbalanced learning methods for CPDP tasks, especially for assessing the effectiveness of imbalanced ensemble learning (IEL) methods. We evaluated the 15 methods by extensive experiments on 31 open-source projects derived from five datasets. Through analyzing a total of 37504 results, we found that in most cases, the IEL method that combined under-sampling and bagging approaches will be more effective than the other investigated methods.

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Noreen, Sundas, Rizwan Bin Faiz, Sultan Alyahya, and Mohamed Maddeh. "Performance Evaluation of Convolutional Neural Network for Multi-Class in Cross Project Defect Prediction." Applied Sciences 12, no. 23 (November 30, 2022): 12269. http://dx.doi.org/10.3390/app122312269.

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Cross-project defect prediction (CPDP) is a practical approach for finding software defects in projects which have incomplete or fewer data. Improvements to the defect prediction accuracy of CPDP—such as the PROMISE repository, the correct classification of the source data, removing the noise, reducing the distribution gap, and balancing the output classes—are an ongoing challenge, as is the selection of an optimal feature set. This research paper aims to achieve a higher defect prediction accuracy for multi-class CPDP by selecting an optimal feature set through XGBoost combined with an automatic feature extraction using a convolutional neural network (CNN). This research type is explanatory, and this research method is controlled experimentation, for which the independent variable prediction accuracy was dependent upon two variables, XGBoost and CNN. The Softmax layer was added to the output layers of the CNN classifier to classify the output into multiple classes. In our experimentation with CPDP, we selected all 28 versions of the multi-class, in which 11 versions were selected as the source projects, against which we predicted 28 target versions with an average AUC of 75.57%. We validated this research paper’s results through the Wilcoxon test. Therefore, after removing the noise, class imbalances, and the data distribution gap, and treating the PROMISE dataset as multi-class, the optimal features selected through XGBoost and classified through the CNN can substantially increase the prediction accuracy in CPDP as evident from our exploratory data analysis (EDA).

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Дисертації з теми "CPDP"

Tavares, Marcondes Dias. "Avaliação hematológica, bioquímica e hemogasométrica de sangue caprino armazenado em bolsas CPDA-1 E CPD/SAG-M." Universidade Federal Rural do Semi-Árido, 2013. http://bdtd.ufersa.edu.br:80/tede/handle/tede/370.

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Made available in DSpace on 2016-08-15T20:31:25Z (GMT). No. of bitstreams: 1 MarcondesDT_DISSERT.pdf: 728916 bytes, checksum: 8c13a239f8df3b37ffebe85a27801c15 (MD5) Previous issue date: 2013-11-28
Conselho Nacional de Desenvolvimento Científico e Tecnológico
The present study aimed to evaluate the hematological, biochemical and hemogasometric changes in caprine blood stored in CPDA-1 and CPD/SAG-M bags. Seven male, adult, neutered, mixed breed goats weighing an average of 45kg were used. From each animal, 25% of the estimated total blood volume was collected into two plastic bags, one containing CPDA-1 and another with CPD/SAG-M; next they were stored for 42 days. Hematological (number of erythrocytes, packed cell volume, total and plasmatic hemoglobin, degree of hemolysis, mean cell volume, leukocytes), biochemical (glucose, lactate, sodium, potassium, total plasma protein), hemogasometric (pH, bicarbonate, partial pressure of oxygen, partial pressure of carbon dioxide, oxygen saturation, base deficit, total carbon dioxide) and microbiological evaluations were performed in seven moments (T), T0 (immediately after sampling), T7 (seven days), T14 (fourteen days), T21 (twenty-one days) , T28 (twenty-eight days), T35 (thirty-five days) and T42 (forty-two days after sampling). In the two bags there was an increase of plasmatic hemoglobin, degree of hemolysis, lactate, pO2 and a decrease of total hemoglobin and pH. In the bags there was no alteration in the erythrocyte count, glucose, sodium, potassium or partial pressure of carbon dioxide. In the comparison with the CPDA-1, the CPD/SAG-M bag had lower erythrocytes, packed cell volume, total hemoglobin and sodium, as well as higher levels of hemolysis and plasmatic hemoglobin. The changes observed in the caprine blood stored for 42 days in CPDA-1 and CPD/SAG-M bags were not sufficient to invalidate their use as a therapeutic resource, however, it has been found that it is preferable to use CPDA-1 bags for the conservation of caprine blood
O presente trabalho objetivou fazer avaliação hematológica, bioquímica e hemogasométrica do sangue caprino armazenado em bolsas CPDA-1 e CPD/SAG-M. Foram utilizados 7 caprinos machos, adultos, castrados, sem raça definida, pesando em média 45kg. O sangue foi coletado em duas bolsas plásticas, uma contendo CPDA-1 e outra CPD/SAG-M, sendo armazenadas durante 42 dias. Realizou-se avaliações hematológicas (número de eritrócitos, volume globular, hemoglobina total e plasmática, grau de hemólise, volume corpuscular médio, leucócitos), variáveis bioquímicas (glicose, lactato, sódio, potássio, proteínas totais), variáveis hemogasométricas (pH, bicarbonato, pressão parcial de oxigênio e de dióxido de carbono, saturação de oxigênio, déficit de base, dióxido de carbono total) e microbiologia, em sete momentos (T), sendo T0 (imediatamente após a coleta), T7 (sete dias), T14 (quatorze dias), T21 (vinte e um dias), T28 (vinte e oito dias), T35 (trinta e cinco dias) e T42 (quarenta e dois dias após a coleta). Nas duas bolsas houve aumento da hemoglobina plasmática, grau de hemólise, lactato, pressão parcial de oxigênio, redução de hemoglobina total e pH. Nas bolsas não houve variação no número de eritrócitos, glicose, sódio, potássio e pressão parcial de dióxido de carbono. Na comparação com a CPDA-1, a bolsa CPD/SAG-M apresentou menores valores de eritrócitos, VG, hemoglobina total e sódio, e maiores valores de grau de hemólise e hemoglobina plasmática. As alterações observadas no sangue caprino armazenado durante 42 dias, em bolsas CPDA-1 e CPD/SAG-M, não foram suficientes para invalidar seu uso como recurso terapêutico

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Bertoletti, Bianca. "Peroxidação lipídica e parâmetros bioquímicos do sangue total felino armazenado em bolsas plásticas contendo CPDA-1 e CPD/SAG-M." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/10099.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
This study aimed to evaluate the influence of lipid peroxidation on decrease of erythrocyte viability in total blood of cats stored in plastic bags containing CPDA-1 (citrate phosphate dextrose adenine) and CPD / SAG-M (citrate, phosphate, dextrose, saline, adenine, glucose, mannitol) for 28 days. It was also analyzed the biochemical and hematological parameters of feline blood throughout the storage period. To this end, were used 12 cats, adult, healthy, male and female, mixed breed, weighing on average 3.5 ± 0.6 kg. The animals were randomly divided into two experimental groups, designated G1 and G2, which was collected on average 15 mL/kg of blood, and stored in bags for shipment of blood products. For the preservation of blood it was used to G1 and G2 CPDA-1 and CPD / SAG-M, respectively. The blood was kept under refrigeration (1-6 ° C) for 28 days and samples were taken for analysis weekly. These rates were evaluated for lipid peroxidation measured by TBARS (thiobarbituric acid reactive substances), erythrocytes peroxidation in vitro, concentrations of potassium (K +) , lactate, glucose and extracellular hemoglobin, erythrocyte count, hematocrit (Ht), hemoglobin (Hb) and total plasma protein (TPP) Through these evaluations it was found that the lactate, potassium and extracellular hemoglobin are effective parameters to evaluate the quality of stored blood to felines and the analysis of TBARS applies to prove the association of lipid peroxidation decreased the viability of blood, also for the felines. Moreover, CPD/SAG-M was more efficient than CPDA-1 in maintaining the viability of the feline blood after 14 days in a storage period of 28 days.
Esse estudo teve por objetivo avaliar a influência da peroxidação lipídica sobre a diminuição da viabilidade eritrocitária no sangue total de gatos, armazenado em bolsas plásticas contendo CPDA-1 (citrato, fosfato, dextrose, adenina) e CPD/SAG-M (citrato, fosfato, dextrose, salina, adenina glicose, manitol) durante de 28 dias. Também se buscou analisar os parâmetros bioquímicos e hematológicos do sangue felino durante todo o período de armazenamento. Para tal, foram utilizados 12 gatos, adultos, hígidos, de ambos os sexos, sem raça definida (s.r.d.), pesando em média 3,5±0,6 kg. Os animais foram distribuídos aleatoriamente em dois grupos experimentais, denominados G1 e G2, dos quais se coletou em média 15 mL/kg de sangue, e armazenou-se em bolsas para transferência de hemoderivados. Para a conservação do sangue do G1 foi utilizado CPDA-1 e, para o G2, utilizou-se CPD/SAG-M. O sangue foi mantido sob refrigeração (1 a 6ºC) durante 28 dias e foram retiradas amostras para análise semanalmente. Essas alíquotas foram avaliadas quanto à peroxidação lipídica, medida através de TBARS (substâncias que reagem ao ácido tiobarbitúrico), peroxidação de eritrócitos in vitro concentrações de potássio (K+), lactato, glicose e hemoglobina extracelular, contagem total de eritrócitos, hematócrito (Ht), hemoglobina (Hb), e proteínas plasmáticas totais (PPT) Por meio dessas avaliações constatou-se que os níveis de lactato, potássio e hemoglobina extracelular são eficientes parâmetros para avaliação da qualidade do sangue estocado para e espécie felina e que a análise de TBARS é válida para comprovar a associação da peroxidação lipídica à diminuição da viabilidade sanguínea, também para a espécie felina. Além disso, CPD/SAG-M mostrou-se mais eficiente que CPDA-1 na manutenção da viabilidade do sangue felino a partir do 14o dia, em um período de estocagem de 28 dias.

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Sonaglio, Franciele. "Avaliação bioquímica in vitro do concentrado de eritrócitos felino Armazenado em soluções de cpda-1 e cpd/sagm durante 35 dias." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/96918.

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O curto tempo de armazenamento dos hemocomponentes é um dos fatores que dificulta e limita a quantidade de sangue que pode ser efetivamente armazenada, o que é uma desvantagem na medicina veterinária, pois o acesso a doadores é restrito e a demanda é contínua e cada vez maior na prática de clínicas e hospitais veterinários. Durante o armazenamento do sangue em baixas temperaturas, seja sob a forma de sangue total ou concentrado de eritrócitos, há uma queda intensa de metabólitos importantes para a viabilidade e funcionalidade dos eritrócitos. O desenvolvimento de meios e soluções de preservação sanguínea possibilitou o armazenamento dos eritrócitos e, consequentemente, facilitou o trabalho dos bancos de sangue. Portanto, a busca por melhores formas e soluções para preservação capazes de evitar ou diminuir estes efeitos prejudiciais durante o seu armazenamento é contínua, para que ao final se obtenha uma melhor qualidade do sangue transfundido. O presente trabalho avaliou o concentrado de eritrócitos felino armazenado na solução de CPDA-1 e CPD/SAGM durante 35 dias. Os dados laboratoriais foram comparados entre grupos e ao longo do tempo. Neste experimento foram utilizadas 10 bolsas de concentrado de eritrócitos felino divididos em dois grupos de cinco para avaliação de cada um dos aditivos. Os parâmetros laboratoriais K+, Na+, Cl-, lactato, HCO3-, amônia, glicose e pH foram avaliados nos dias 1, 7, 14, 21, 28 e 35 após a coleta. Vários parâmetros (K+, lactato, HCO3, glicose e cloreto) demonstraram que a solução CPD/SAGM manteve o metabolismo energético do eritrócito mais estável. Com este trabalho, foi possível entender melhor as alterações metabólicas sofridas pelos eritrócitos felinos durante o armazenamento. Concluímos que, apesar da solução CPD/SAGM se mostrar mais eficaz in vitro, são necessários mais estudos com relação aos hemocomponentes em gatos e à sua viabilidade pós-transfusional.
The short shelf life of blood products is one factor that complicates and limits the amount of blood that can be effectively stored, and it is a disadvantage in veterinary practice, because the access to donors is restricted and the demand is continuous and increasing at veterinary clinics and hospitals. During blood storage at low temperatures, either as whole blood or as packed red cells, there is a significant decrease of metabolites that are important for the viability and functionality of erythrocytes. The development of blood preservation solutions has enabled the storage of red blood cells and improved the service at the blood banks. Therefore, the search for better ways and blood preservation solutions to avoid or reduce these harmful effects during the storage conditions is continuous, in order to obtain the best blood product to be transfused. This study evaluated 10 bags of feline erythrocyte concentrate divided into two groups, stored in CPDA-1 and CPD/SAGM solutions during 35 days. The laboratory data were compared between groups and over time. K+, Na+, Cl-, lactate, HCO3-, ammonia, glucose and pH were assessed on days 1, 7, 14, 21, 28, and 35 after collection. On various parameters (K+, Cl-, HCO3-, glucose and lactate) solution of CPD/SAGM kept the energy metabolism of red blood cells more stable. With these results we can better understand the biochemical changes of feline erythrocytes during storage. We conclude that, although the CPD/SAGM solution shown to be more effective, more studies are needed to improve knowledge of feline blood components and post-transfusion viability.

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Moroz, Ludmila Rodrigues. "Perfil bioquímico e hemogasométrico de concentrado de hemácias canino coletados em CPDA-1 e CPD/SAG-M, com e sem filtro de redução de leucócitos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-26082015-150252/.

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A medicina transfusional utiliza o sangue como ferramenta terapêutica suporte para diversas doenças, e vários estudos justificam o uso de hemocomponentes em detrimento de sangue total. A estocagem e a manipulação do sangue podem acarretar alterações funcionais de seus subprodutos, e a transfusão de hemácias estocadas por longos períodos pode ocasionar danos ao receptor. Portanto, embora a manutenção do estoque de componentes eritrocitários seja necessária, o armazenamento sanguíneo pode reduzir a função das hemácias transfundidas e causar reações transfusionais indesejadas, fato que estimula o desenvolvimento de novas soluções e aditivos extras, culminando com hemocomponentes mais seguros e com maior tempo de validade. Este estudo teve o objetivo de avaliar as alterações na composição bioquímica e hemogasométrica que pudessem ser imputadas na ocorrência de lesões de armazenamento no concentrado de hemácias (CH) canino em decorrência do tipo de solução preservativa utilizada (citrato, fosfato, dextrose e adenina [CPDA-1] ou com o citrato, fosfato, dextrose com solução extra de adenina, glicose e manitol [CPD/SAG-M]). Um segundo objetivo foi avaliar se a redução de leucócitos do CH impactaria de forma decisiva a estocagem do CH. Para tanto foram comparados valores referentes à pressão de oxigênio (PO2), pressão de dióxido de carbono (PCO2), saturação de oxigênio (SO2), pH, taxa de hemólise, glicose, sódio e potássio extracelulares. As bolsas foram analisadas a cada sete dias, iniciando 12 horas após a colheita até completar 42 dias (seis semanas de estocagem). Foram estudadas 23 bolsas divididas em quatro grupos, sendo o Grupo 1 de CH colhido em CPDA-1 (6 bolsas), Grupo 2 em CPDA-1 leucorreduzido (6 bolsas), Grupo 3 em CPD/SAG-M (6 bolsas) e Grupo 4 em CPD/SAG-M leucorreduzido (5 bolsas). Dentre os resultados, não foram observadas alterações significativas na taxa de hemólise que pudessem indicar qual anticoagulante foi mais eficaz, tão pouco se a leucorredução possuiu efeito preservante dos eritrócitos. Também não houve diferenças significativas na concentração de glicose e pH entre os grupos durante as semanas de estudo. Foram observadas diferenças na concentração de potássio extracelular, com menor concentração nas bolsas leucorreduzidas. A variação da PCO2 não apresentou um comportamento padrão de aumento ou redução com diferenças significativas claras. Contudo, foram observadas mudanças marcantes no comportamento da concentração de oxigênio ao se comparar a presença ou ausência dos leucócitos, independente do anticoagulante utilizado, com aumento marcante nos valores de PO2 nos grupos leucorreduzidos a partir da segunda semana (P<0,05). A SO2 apresentou diferença significativa entre os grupos que sofreram ou não leucorredução desde a semana zero (P<0,05), com valores maiores nos grupos leucorreduzidos, independente do anticoagulante utilizado nas semanas 1 até 5. Conclui-se analisando os dados que a solução preservativa CPD/SAG-M não ofereceu melhor meio para estocagem de CH canino quando comparado ao CPDA-1 no que tange a hemólise, mas que a redução de leucócitos (leucorredução) indicou efeito protetivo indireto da estrutura eritrocitária de CH canino em estocagem, independente do anticoagulante utilizado, observado pela menor concentração de potássio a partir de 35 dias de estocagem (quinta semana). Concluiu-se, também, que a leucorredução exerceu um impacto na concentração de oxigênio mensurado pela PO2 e SO2, indicando melhor função in vitro da hemoglobina, independente do anticoagulante utilizado
The transfusional medicine use blood as a therapeutic support tool for various diseases, and many studies justify the use of blood products at the expense of whole blood. The storage and handling of blood can result in functional changes of these products, and the transfusion of long time storage erythrocytes may be harmful to the receiver. Therefore, while the maintaining the stock of red cell components is required, blood storage can reduce the function of transfused red blood cells and cause unwanted transfusion reactions, a fact that stimulates research in the field of development of new solutions and extra additives, culminating in safer blood products and with longer validity. This study aimed to evaluate variations in the biochemical and hemogasometric composition that could be changed in the event of storage lesions in canine packed red blood cells (PRBC) due to the type of used preservative solution (citrate, phosphate, dextrose and adenine [CPDA -1] or citrate, phosphate, dextrose solution with extra adenine, glucose and mannitol [CPD/SAG-M]). A second objective was to assess whether the reduction of CH leukocytes could impact decisively in the storage of PRBC. Therefore, we compared the values for oxygen pressure (PO2), carbon dioxide pressure (PCO2) and oxygen saturation SO2), pH hemolysis rate, glucose, extracellular sodium and potassium. The blood bags were analyzed every 7 days starting 12 hours after harvest and during 42 days (six weeks of storage). It were studied 23 bags divided into four study groups: Group 1 PRBC harvest in CPDA-1 (6 bags), Group 2 leukoreduced CPDA-1 (6 bags), Group 3 CPD/SAG-M (6 bags) and group 4 in CPD/SAG-M leukoreduced (5 bags). Among the results, there were no significant changes in hemolysis rate were observed which could indicate which anticoagulant was more effective, as little to leukoreduction owned preservative effect of erythrocytes. There were also no significant differences in glucose concentration and pH between the groups during the week study. Differences were observed in extracellular potassium concentration, with lower concentrations in leucorreduced bags. The variation of PCO2 was wandering without formation of an increase or decrease in behavior clear differences. However, significant changes in the behavior of oxygen concentration when comparing the presence or absence of leukocytes were observed independent of the anticoagulant was used, with marked increase in PO2 values in leukorreuced groups from the second week (P <0.05). The SO2 showed a significant difference between the groups that have suffered or not leukoreduction from week zero (P <0.05), with higher values in leukoreduced groups, independent of the anticoagulant used in weeks 1 to 5. We conclude by analyzing the data that preservative solution CPD / SAG-M offered no better way to canine CH storage when compared to the CPDA-1 with respect to hemolysis, but that leukocyte reduction (leukoreduction) indicated indirect protective effect of erythrocyte structure of CH canine in storage, independent of the anticoagulant used, observed by the lower concentration of potassium from 35 days of storage (fifth week). It was concluded also that leukoreduction exerted an impact on oxygen concentration measured by PO2 and SO2, indicating better function of hemoglobin in vitro, independent of the anticoagulant used

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Pieraccini, Léa Marie Michèle. "Eficácia da ventilação não invasiva nos grandes prematuros com síndrome de dificuldade respiratória: uma revisão bibliográfica." Bachelor's thesis, [s.n.], 2017. http://hdl.handle.net/10284/6264.

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Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Fisioterapia
Objetivo: Averiguar o papel da ventilação não invasiva (VNI) nos grandes prematuros (idade gestacional <34 semanas) com síndrome de dificuldade respiratória (SDR). Metodologia: Pesquisa computorizada nas bases de dados PubMed e PEDro para identificar estudos randomizados controlados que avaliam a eficácia da VNI nos grandes prematuros com SDR. Resultados: Nesta revisão foram incluídos 10 estudos envolvendo 840 lactentes, com classificação metodológica media de 6.2 em 10 na escala de Physiotherapy Evidence Database (PEDro), dos quais 1 compara o Continuous Positive Airway Pressure (CPAP) com a ventilação convencional contínua, 3 comparam o CPAP com o Nasal Intermittent Positive Pressure Ventilation (NIPPV), 2 comparam o CPAP com o Bi-level Positive Airway Pressure (BiPAP) e 4 comparam a eficácia do CPAP segundo os fluxos aplicados. Conclusão: Os estudos incluídos nesta revisão sugerem que o CPAP é eficaz, mas existem outras técnicas de VNI como a NIPPV que podem ser mais eficazes, mas que não são muito aplicadas porque ainda não são bem conhecidas. Sugere-se mais estudos sobre estas modalidades para provar a eficácia das outras técnicas de VNI.
Objective: To determine the role of non-invasive ventilation (NIV) in very preterm (gestational age <34 weeks) with respiratory distress syndrome (RDS). Methodology: Research computerized on databases PubMed and PEDro to identify randomized controlled studies that evaluate the effectiveness of NIV in very preterm with RDS. Results: In this review were included 10 studies involving 840 babies, with methodology classification of 6.2 on the Physiotherapy Evidence Database Scale (PEDro). From that, 1 study compares the Continuous Positive Airway Pressure (CPAP) with the conventional mechanical ventilation, 3 studies compare the CPAP with the Nasal Intermittent Positive Pressure Ventilation (NIPPV), 2 studies compare CPAP with the Bi-level Positive Airway Pressure (BiPAP) and 4 compare the effectiveness of CPAP according to the flows applicated. Conclusion: The reviews suggest that the CPAP is effective, but there are other more NIV techniques like a NIPPV that can be more effective, but are not very used because they are not yet well known. To provide a better proof of effectiveness of the other NIV techniques, more studies are needed on the modalities.
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Hucken, Sabine. "Untersuchungen zur Regulation der cPIP- Synthase." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971382999.

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Mimoso, José Carlos Pinto. "The Community of Portuguese Speaking Countries Organization : A Strategic Analysis as a Security Enhancement Intergovernmental Organization." Master's thesis, U.S. Army Command and General Staff College, 2012. http://hdl.handle.net/10400.26/4409.

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The current wide-ranging and complex relations in the international environment demand a comprehensive approach to challenges in world security. Regional organizations play a decisive role in the peaceful settlement of disputes and conflict prevention. This is especially important in Africa given the many enduring problems that affect this continent. Considering that security is a basic condition for development and prosperity, this study aims to assess the Community of Portuguese Speaking Countries (CPLP) organization’s ability to promote stability in its African member states and the CPLP’s aptitude to help resolve a crisis situation and return to stability. The research concluded that the CPLP is an intergovernmental organization capable of enhancing the security of its African country members. Even without an organizational defined policy towards defense and security, CPLP developed a Defense Cooperation Protocol that defined the overarching goals to promote defense cooperation among the CPLP members and defined a defense structure for the organization. The Community also demonstrated its capabilities through the political and diplomatic dialogue concerning the stability in its African country members. This commitment allowed the Community to play an important role in addressing crisis situations within its members and led to the international community recognizing these actions.

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Hofmann, Markus. "Notwendigkeit einer Druckveränderung bei Patienten mit CPAP (Continuous Positive Airway Pressure)-Therapie 2 - 3 Monate nach der Ersteinstellung." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60436.

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Lafos, Marcel. "Komplementationsstudien der cpd-Mutante und Analyse der CPD-Interaktionspartner mittels reverser Genetik." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=978805313.

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Rothwell, Andrew Trevor. "Professionals, CPD and employability." Thesis, Loughborough University, 2004. https://dspace.lboro.ac.uk/2134/11574.

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This thesis presents the findings of a study of U.K. Human Resources professionals, and factors relating to their Continuing Professional Development or CPD. The study has investigated their attitudes to CPD (CPDV), what CPD they actually engage in (CPDE), and the statistical relationships between employability, CPD, and a number of biographical and attitudinal variables. As a subsidiary aim, the study developed and tested a scale of employability, as no appropriate measure was discovered prior to the field research being undertaken. While the respondents engaged in CPD, they did so for reasons of professional commitment rather than a concern for their employability, and that the CPD undertaken tended to be either informal or organisationally-driven. Examination of relationships between the study variables using multiple hierarchical regression saw biographical variables explain 4.1 % of the variance in the perceived value of CPD, and attitudinal variables a further 13.5%. Biographical variables explained 10.7% of the variance in employability, and attitudinal variables a further 30.3%. The study has concluded that professional organisations may have some way to go before they achieve the comprehensive engagement with CPD that may become (and is already in some organisations) mandatory, and that this gap relates to individual's self perceived needs in addition to aspects of record keeping and attitudes to the profession generally. More encouraging has been the development of a new measure of individual employability that compares well against the limited empirical literature in the field, and appears to be a distinct construct to SUbjective career success. Overall, the study has contributed to our understanding of professionals, their attitudes and values, and especially their attitude to and engagement with CPD. Although it was not an original aim, the development of the scale of individual employability may well turn out to be the principal theoretical and practical contribution of this research, as a concept that becomes part of a new paradigm of the psychology of work in the 21st century.

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Книги з теми "CPDP"

Muythan, Ko. Cpâp bānijjakamm. 2nd ed. [Phnom Penh]: Paṇṇagār Qaṅgar, 2007.

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Sākalvidyālăy Jāti Grápgraṅ. Mahāvidyālăy Nitisātr. Mūlṭhān cpâp niṅ sthāpăn cpâp = Legal principles and institutions. 2-ге вид. Phnom Penh]: Mahāvidyālăy Nitisāstr, Sākalvidyālăy Jāti Grápgraṅ, 2010.

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Instituto Nacional de Estatística (Portugal). Estadísticas da CPLP. Lisboa: Instituto Nacional de Estatística, 2000.

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Ṅűy. Cpâp Kraṃ Nũy. [Phnom Penh]: Buddhasāsanapaṇḍity, 1985.

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plc, Barbour Index, ed. CPD briefing. Windsor: Barbour Index plc, 1995.

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plc, Barbour Index, ed. CPD briefing. Windsor: Barbour Index plc, 1999.

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plc, Barbour Index, ed. CPD briefing. Windsor: Barbour Index plc, 1996.

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plc, Barbour Index, ed. CPD briefing. Windsor: Barbour Index plc, 1997.

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Seminário "Comunidade dos Países de Língua Portuguesa-CPLP: Oportunidades e Perspectivas" (2002 Brasília, Brazil). CPLP: Oportunidades e perspectivas. Brasília, DF: IPRI, FUNAG, 2002.

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UNICEF--Malawi. Country programme (CPAP) 2008-2011. Lilongwe: Government of Malawi, UNICEF, 2007.

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Частини книг з теми "CPDP"

Bernard-Thierry, Solange, and Sascha Ebeling. "Cpāp'." In Kindlers Literatur Lexikon (KLL), 1–4. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_22953-1.

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Galetke, Wolfgang, and Heinrich F. Becker. "CPAP." In Springer Reference Medizin, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_253-1.

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Bass, R. "EEC/CPMP." In The Contribution of Acute Toxicity Testing to the Evaluation of Pharmaceuticals, 55–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70390-4_8.

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Peter, Helga. "Sham CPAP." In Springer Reference Medizin, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_888-1.

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Galetke, Wolfgang, and Heinrich F. Becker. "Automatisches CPAP." In Springer Reference Medizin, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_240-1.

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Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, Sarah Parylak, Micaela Morelli, Nicola Simola, Nicola Simola, et al. "CPP." In Encyclopedia of Psychopharmacology, 361. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4154.

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Abbasi, Adeel, Francis DeRoos, José Artur Paiva, J. M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, et al. "CPP." In Encyclopedia of Intensive Care Medicine, 626. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1408.

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Hewett, Victoria. "CPD." In Making it as a Teacher, 182–90. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9780429489341-16.

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Peter, Helga, and Thomas Penzel. "CPAP-Druck, effektiver." In Springer Reference Medizin, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_414-1.

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Peter, Helga, and Thomas Penzel. "Effektiver CPAP-Druck." In Springer Reference Medizin, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_478-1.

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Тези доповідей конференцій з теми "CPDP"

Li, Ke, Zilin Xiang, Tao Chen, and Kay Chen Tan. "BiLO-CPDP." In ASE '20: 35th IEEE/ACM International Conference on Automated Software Engineering. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3324884.3416617.

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Kassiotis, Christophe, and Suzelle Lalaut. "PNGMDR et débat CPDP." In Assainissement/Démantèlement/Gestion des déchets : concertation et enjeux socio-économiques. Les Ulis, France: EDP Sciences, 2019. http://dx.doi.org/10.1051/jtsfen/2019ass01.

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Agarwal, Harshit, Sanchi Prakash, Urvi Agarwal, Prantik Biswas, Aparajita Nanda, and Suma Dawn. "CPDP: A Connection based PDP Algorithm." In 2018 Fifth International Conference on Parallel, Distributed and Grid Computing (PDGC). IEEE, 2018. http://dx.doi.org/10.1109/pdgc.2018.8745786.

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Muddu, Basavaraju, Allahbaksh Asadullah, and Vasudev Bhat. "CPDP: A robust technique for plagiarism detection in source code." In 2013 7th International Workshop on Software Clones (IWSC). IEEE, 2013. http://dx.doi.org/10.1109/iwsc.2013.6613041.

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Amasaki, Sousuke, Hirohisa Aman, and Tomoyuki Yokogawa. "A Preliminary Evaluation of CPDP Approaches on Just-in-Time Software Defect Prediction." In 2021 47th Euromicro Conference on Software Engineering and Advanced Applications (SEAA). IEEE, 2021. http://dx.doi.org/10.1109/seaa53835.2021.00042.

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An, Bai, Zhengli Hua, Takashi Iijima, Chaohua Gu, Jinyang Zheng, and Chris San Marchi. "Scanning Kelvin Probe Force Microscopy Study of Hydrogen Distribution and Evolution in Duplex Stainless Steel." In ASME 2017 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/pvp2017-66121.

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Detecting hydrogen distribution at micro- and nano-scale is important for understanding the mechanisms of hydrogen embrittlement in metals. In this study, scanning Kelvin probe force microscopy (SKPFM), which can detect the variation of surface contact potential difference (CPD) caused by hydrogen, is applied to investigate the hydrogen distribution and evolution in thermally hydrogen-charged (HC) super duplex stainless steel. The SKPFM observations reveal that the CPD distribution becomes nonuniform in both the ferrite and austenite phases after hydrogen charging, implying that hydrogen distributes heterogeneously in the two phases. The average CPDs of both the ferrite and austenite phases are significantly decreased and the difference of CPD between two phases reaches a maximum shortly after thermal hydrogen-charging. The average CPDs of both the ferrite and austenite phases recover and the difference of CPD between two phases is decreased upon release of the hydrogen. These results are discussed in terms of the hydrogen outgasing behavior and the difference of hydrogen diffusivity in the two phases.

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Abueidda, Diab W., and Mohamed Gadalla. "Thermodynamic Analysis of an Integrated Solar-Based Multi-Stage Flash Desalination System." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-87729.

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Worldwide concern about the scarcity of global water resources is increasing day by day. In Gulf countries, most power plants are co-generation power desalting plants (CPDP) that generate electric energy and also produce fresh water through the desalination of seawater. Nowadays, renewable energy provides a viable solution to the scarcity of energy resources and an environmental friendly option of global economy. In this paper, thermodynamic analyses have been performed on an integrated solar-based multi-stage flash desalination/Rankine cycle system. The respective losses as well as the first-law and second-law efficiencies for the system have been evaluated. The first-law and second-law efficiencies of the solar field were found to be 61.70% and 31.74%, respectively. The solar thermal field is based on direct steam generation method. Moreover, the mass flow rate through the Rankine cycle has been optimized to produce the maximum power. The optimal mass flow rate through the Rankine cycle found to be 51 kg/s. Furthermore, this paper presents and investigates a model of distillation plant that can use the heat rejected from the condenser of the Rankine cycle. The model is analyzed and validated with other results gained from literature. It found that the highest exergy destruction through the distillation unit occurs within the stages of the MSF unit. The percentage of exergy destruction in the MSF stages was found to be 75.41% of the total exergy destruction in the distillation unit. Additionally, this study verifies that increasing number of MSF stages decreases the percentage of exergy destruction.

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Bono, Massimo, Alfonso E. Gerevini, Daniel D. Harabor, and Peter J. Stuckey. "Path Planning with CPD Heuristics." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/167.

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Compressed Path Databases (CPDs) are a leading technique for optimal pathfinding in graphs with static edge costs. In this work we investigate CPDs as admissible heuristic functions and we apply them in two distinct settings: problems where the graph is subject to dynamically changing costs, and anytime settings where deliberation time is limited. Conventional heuristics derive cost-to-go estimates by reasoning about a tentative and usually infeasible path, from the current node to the target. CPD-based heuristics derive cost-to-go estimates by computing a concrete and usually feasible path. We exploit such paths to bound the optimal solution, not just from below but also from above. We demonstrate the benefit of this approach in a range of experiments on standard gridmaps and in comparison to Landmarks, a popular alternative also developed for searching in explicit state-spaces.

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Siewiorek, Gail M., and Ender A. Finol. "Experimental and Computational Evaluation of Embolic Protection." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19693.

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Carotid artery stenting (CAS), an endovascular treatment for severe carotid artery occlusive disease, is increasingly considered a complimentary procedure to carotid endarterectomy. One reason for the acceptance of CAS as a viable treatment alternative is cerebral protection devices (CPDs), which can reduce the embolic load in the cerebral vasculature. One particular type of CPD, distal protection filters (DPFs), are a popular choice due to their ability to allow distal perfusion peri-procedurally while filtering and removing plaque emboli from the body. This investigation studied one FDA-approved DPF, RX Accunet, using both in vitro and computational methods.

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Davies, W. L. "Intelligent CPAP." In IEE Colloquium on Sleep Monitoring. IEE, 1995. http://dx.doi.org/10.1049/ic:19951590.

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Звіти організацій з теми "CPDP"

Trujillo, Gabrielle, and Christian Robert Trott. Milestone CPP. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1573930.

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Haggerty, Ryan, Adam Cook, Robert Copeland, Susan Esfahani, Patrick Finnegan, Nathan Fuller, Jeffrey Koplow, et al. CPAP Ventilators Needed for Rapid Response to COVID-19 by Modification of CPAP Equipment. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1668131.

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Peterson, J. Common Profile for Presence (CPP). RFC Editor, August 2004. http://dx.doi.org/10.17487/rfc3859.

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Boucadair, M., C. Jacquenet, and N. Wang. IP Connectivity Provisioning Profile (CPP). RFC Editor, July 2014. http://dx.doi.org/10.17487/rfc7297.

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Kuhlmann, Jim. The Socialization of CPEP Teachers: Implications for Administration. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1399.

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Witkowski, Marc. FILTER ADAPTERS FOR BI-PAP AND CPAP EQUIPMENT. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1659137.

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Jacquenet, C., D. Zhang, and P. Georgatsos. Dynamic Service Negotiation: The Connectivity Provisioning Negotiation Protocol (CPNP). Edited by M. Boucadair. RFC Editor, October 2020. http://dx.doi.org/10.17487/rfc8921.

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Reardon, Robert, Jill Lumsden, and Katie Meyer. The FSU Online Career Portfolio Program (CPP). Florida State University Libraries, August 2004. http://dx.doi.org/10.17125/fsu.1525970870.

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Weidlich, Christopher. CPSP as a Mediator or Resiliency and Coping among Military Healthcare. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada608096.

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Maugham, Charlotte. Land governance and transparency livelihoods. CPD event: overview. Evidence on Demand, January 2013. http://dx.doi.org/10.12774/eod_cr.nov2013b.maugham.

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