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Talley, Nicholas J. "Managing Chronic Constipation From Constipating Medicines." Southern Medical Journal 100, no. 11 (November 2007): 1070–71. http://dx.doi.org/10.1097/smj.0b013e318157ec3d.
Muawanah, Muawanah, and Triska Susila Nindya. "HUBUNGAN ASUPAN SERAT DAN CAIRAN DENGAN KEJADIAN KONSTIPASI PADA IBU PASCA MELAHIRKAN." Media Gizi Indonesia 11, no. 1 (May 15, 2017): 101. http://dx.doi.org/10.20473/mgi.v11i1.101-105.
Postpartum constipation with symptoms such as pain or discomfort, straining and hard stools is a common condition that affects the incidence of hemoroids and pain in the area of episiotomy. Constipation is associated with inadequate intake of fi ber and fl uid. This study aimed to analyze the relationship between intake of fiber, fluids and constipationin postpartum mother. The study design was observational with cross sectional approach on thirty three (33) post partum mothers using systemic random sampling method in April to May 2016. Data was analyzed by chi-square test. The result showed that 97% of postpartum mother had inadequate fi ber intake and only 3% were adequate. There was 9.1% postpartum mother with inadequate fluid intake and 90.9% were categorized as adequate. There was 54.5% of postpartum mother had constipation, while 45.5% not constipated. Based on chi-square test, there was no signifi cant relationship between fiber intake, fluid intake and constipation (p > 0.05). The conclusion that there was no relationshipin fiber intake, fluid intake with the incidence of constipation in postpartum mother. This requires provision of health education to prevent the occurance of constipation in postpartum mother.Keywords: fluid intake, fiber intake, constipation, postpartum
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Sudnickaitė, Urtė, Brigita Aidukienė, and Kazys Simanauskas. "Frequency, Causes, Diagnostics and Treatment of Constipation in Family Doctors Work." Sveikatos mokslai 25, no. 2 (April 20, 2015): 46–53. http://dx.doi.org/10.5200/sm-hs.2015.030.
Constipation is a highly prevalent disorder in the primary care. The observed morbidity differences between gender, age, socioeconomic classes with different feeding habits, physical activity and related diseases. Aim. To evaluate causes, diagnostic, treatment features of constipation in the primary care. Methods: was made random interviews of people between 20-80 years old. For interview was used questionnaire of KESS (The Knowles- Eccersley- Scott- Symptom scoring system) for the diagnostic of constipation and 13 questions to assess the risks. The pilot testing of questionnaire validity was carried out, the overall Cronbach alpha coefficient is 0.978. Statistical analysis was performed using Microsoft Office Excel 2007 and SPSS 13.0 for Windows data packets. Results. Was interviewed 320 people, of which 33.13% were established constipations. The average duration of constipation ranged from 18 month up 5 years. The average age of patients with constipation was 56±14.99 years and the healthy group- 41±14.20 years (p0,05). No differences were observed between man and women (p>0.05). Educational groups incidence of constipation was: high education – 29.19%, secondary – 30.3% and basic – 70.37%. We found, that most respondents eat irregularly, 3-4 times per day. We found, that increased fiber food usage, higher intake of fluid was correlated with lower incidence of constipation, as well as higher levels of physical activity or related chronic diseases (p 0.05). In assessing treatment, laxatives was used by 132 respondents, including 75.76% of patients with constipation and enemas was used by 53 respondents, including 94.43% of patients with constipation. Observed that only 62.26% of patients with constipation reported seeing a physician and 96.23% are treated independently. Conclusions: Purposefully interview of patients observed there is a high incidence of constipation. Differences of morbidity between genders are not observe, different than age and education groups. Not all investigated risk factors affect the incidence of constipation increased; mostly affects the small fluid, fiber food intake, physical activity and related chronic diseases. Patients are not give importance to this issue, and so thats why they do not seek a physician often and are treated independently.
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Hida, Yuki, Teruhiko Imamura, and Koichiro Kinugawa. "Constipation as a Drug-Related Adverse Effect in Patients with Hyperkalemia: Sodium Zirconium Cyclosilicate versus Conventional Potassium Binders." Journal of Clinical Medicine 12, no. 18 (September 14, 2023): 5971. http://dx.doi.org/10.3390/jcm12185971.
(1) Background: Constipation is one of the most serious adverse effects of potassium-lowering agents and decreases patients’ quality of life. Sodium zirconium cyclosilicate (SZC) is a recently innovated potassium binder intended for patients with hyperkalemia. The impact of SZC on the worsening of constipation, as compared with conventional potassium binders, remains unknown. (2) Methods: Patients with hyperkalemia who continued SZC for over 3 months between July 2020 and May 2022 were included in this retrospective study. Patients who received other conventional potassium binders during the same period were included as a control group. Trends in the doses of anti-constipation agents during the 3-month therapeutic period were compared between the two groups as a surrogate for worsening constipation. (3) Results: A total of 50 patients (median age 74 years, 31 male) were included, consisting of 22 patients with SZC and 28 patients with other conventional potassium binders. All patients had hyperkalemia and chronic kidney disease at baseline. During the 3-month therapeutic period, serum potassium levels decreased significantly in both groups (p < 0.05 for both). The number of anti-constipation remained unchanged in the SZC group but tended to increase in the control group (p = 0.56 and p = 0.090, respectively). The total dose change in all anti-constipations was significantly lower in the SZC group than in the control group (p = 0.037). (4) Conclusions: Conventional potassium binders have a tendency to worsen constipation, whereas SZC may have the potential to improve hyperkalemia without worsening constipation. SZC may be recommended, particularly in elderly patients with ongoing or high-risk constipation.
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Ferrazzi, Simon, Grant W. Thompson, E. Jan Irvine, Pierre Pare, and Laureen Rance. "Diagnosis of Constipation in Family Practice." Canadian Journal of Gastroenterology 16, no. 3 (2002): 159–64. http://dx.doi.org/10.1155/2002/740413.
BACKGROUND: Patients who complain of constipation to their family doctor may not be truly constipated. Variability in stool frequency and consistency, and perception of symptoms may lead to inaccurate patient reporting or diagnosis of constipation.OBJECTIVES: To determine whether patients visiting their family doctor with a complaint of, or diagnosed with, constipation fulfilled the Rome II criteria for functional constipation and had stool characteristics of constipation.METHODS: A random sample of Canadian family physicians were recruited to enroll a series of adults who complained of, or had received a diagnosis of, constipation during an office visit. Patients were advised of the survey. Those providing written consent were contacted by an independent research firm and forwarded a survey questionnaire that included the Rome II gastrointestinal questionnaire, questions regarding their medical history and questions regarding their demographics. Patients also completed a four-week daily diary recording their bowel habits using the Bristol Stool Form Scale, medication use and satisfaction with treatment. Questionnaire and diary responses were retrieved by telephone.RESULTS: One hundred eighty-four family physicians enrolled 311 patients, of whom 220 completed the questionnaire. Females comprised 79.5% of the sample and had a mean age of 54.2 years (males 61.6 years; P<0.05). According to the Rome II criteria, 37.3% had functional constipation and 46.8% had irritable bowel syndrome (IBS). Whole gut transit times estimated using the Bristol Stool Scale were similar among those with self-reported constipation, those with Rome II functional constipation and those with Rome II IBS (79.3 h, 85.8 h and 77.4 h, respectively). Almost half of the patients with IBS or functional constipation were taking a pain medication, while nearly one-fifth took antidepressants. Of the medications or remedies taken to treat constipation, patients rated 49.8% of the doses as satisfactory.CONCLUSIONS: A large proportion of Canadian primary care patients whose presenting complaint or diagnosis was constipation satisfied the Rome II criteria for IBS, with a smaller number defined as functionally constipated. IBS patients tended to be younger than those with functional constipation, and whole gut transit times did not differentiate IBS from functional constipation. Careful questioning of patients who complain of constipation may reveal constipating medication, diarrhea symptoms or IBS.
McShane, Ruth E., and Audrey M. McLane. "Constipation." Nursing Clinics of North America 20, no. 4 (December 1985): 801–8. http://dx.doi.org/10.1016/s0029-6465(22)01923-5.
Preston, David Michael. "The chronic constipation of young women." Thesis, King's College London (University of London), 1985. https://kclpure.kcl.ac.uk/portal/en/theses/the-chronic-constipation-of-young-women(72636ff6-ebe9-4aee-b0bf-db57a4b22a5d).html.
Lee, Eun Jin. "THE EFFECT OF ACUPRESSURE ON CONSTIPATION, QUALITY OF LIFE, AND DEPRESSIVE SYMPTOMS IN CANCER PATIENTS WITH CONSTIPATION." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/14.
Constipation is the most common gastrointestinal complaint in the United States, resulting in about 2 million annual visits to the doctor.
The purposes of this dissertation were to: 1) describe four theories of traditional Korean medicine; 2) review mechanisms of acupuncture and moxibustion and develop a conceptual model; 3) review findings from randomized controlled trials that tested the effects of acupressure used for the management of symptoms such nausea, pain, and dyspnea; 4) examine the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) in heart failure patients with constipation compared to those with gastrointestinal disease; 5) describe how Korean women experienced constipation and how constipation affected the quality of life and the experience of using complementary and alternative medicine for constipation; 6) test the effect of acupressure on constipation and to examine the quality of life and depressive symptoms in cancer patients with constipation.
Meridian theory explains that acupressure stimulates meridians, a network of energy pathways in the body to increase the flow of bio-energy. Authors of 48 studies supported that acupressure reduced nausea and vomiting during pregnancy, pain, fatigue, and dyspnea.
The Patient Health Questionnaire-9 (PHQ-9) was used to examine the depressive symptoms in cancer patients with constipation, but has not been tested in patients with constipation. Therefore, in this study, the psychometric properties of PHQ-9 were tested in patients with constipation. Cronbach’s alphas for the Patient Health Questionnaire were .89 and the correlation between the PHQ-9 and the BDI-II (Beck Depression Inventory) was .81 (p<.01) in 382 heart failure patients with constipation.
Ten Korean women reported that living with constipation is a stressful and uncomfortable experience which impacts daily activity, lifestyle, social relationships, and diet.
In this pilot study, three out of five patients in the acupressure group reported that acupressure was effective in improving constipation. Cancer patients with less than a four-month history of constipation had less depressive symptoms and higher quality of life compared to patient with more than a four-month history of constipation. In conclusion, acupressure can be a safe and cost effective alternative medicine for constipation.
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MICHELLAND, OLIVIER. "Contribution a l'etude de la constipation terminale." Clermont-Ferrand 1, 1990. http://www.theses.fr/1990CLF13828.
Berg, Maartje-Maria van den. "Childhood constipation abnormalities in the colorectal function /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/48517.
Knowles, Charles H. "Slow transit constipation : clinical and aetiological studies." Thesis, Queen Mary, University of London, 2000. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1515.
Constipation is the second most commonly self-reported gastrointestinal symptom. On the basis of anorectal physiological investigations and colonic transit studies, a subgroup of patients with several intractable symptoms, but without organic disease will be found to have slow transit constipation (STC). STC is a condition of gut dysmotility which predominantly affects young women, and may result in surgical intervention with variable, often unsatisfactory results. The aetiology remains elusive. New aetiological hypotheses for STC were examined following full clinical and pathophysiological characterisation of a large cohort of 130 patients referred to our institution over the last 10 years. Aspects of nerve and muscle dysfunction were studied. A new scoring system demonstrated some ability of multiple symptoms to discriminate STC from other forms of constipation. Detailed clinical and gastrointestinal physiological studies confirmed the heterogeneity of STC patients. Some significant physiological differences were detectable between clinically defined sub-groups of patients and refuted previous assumptions based on smaller numbers. Detailed neurophysiological studies, including quantitative peripheral sensory and autonomic testing, provided evidence of a small fibre neuropathy in a proportion of patients with STC. Mutational screening of some early-onset cases for a possible congenital pathogenetic mechanism, based on the observation that some STC patients had relatives with Hirschsprung's disease demonstrated that mutation of 2 important genes now implicated in this disorder were not a frequent cause of STC. Serum immunoprecipitation assays showed that anti-neuronal ion channel autoantibodies may have an as yet unrecognised role in the development of STC in a small proportion of acquired cases. An inclusion body myopathy was identifiable in colonic tissue of patients with STC, and this appeared to arise secondary to denervation. Further knowledge of the single or multiple pathogenetic mechanisms leading to this clinical condition may allow more rational or directed therapies aimed at the correction of the disease process or processes themselves.
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Hogan, Georgiana, Janice Lazear, Jean Croce Hemphill, Catherine Hebert, and Emily Wood. "Constipation in the Long-Term Care Resident." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/4.
An evidence-based clinical practice guideline was developed to prevent and manage constipation in the long-term care (LTC) resident. Constipation is a prevalent condition in the LTC resident. Guidelines do not address this vulnerable population. Constipation may result in poor nutritional status, quality of life along with increased health care costs and hospitalizations. A literature review was completed and evidence was evaluated and included into the initial draft recommendations. The guideline was reviewed for content validity using a Delphi Committee of clinical experts in gastroenterology, geriatrics, and pharmacy. The updated guidelines were presented to an interdisciplinary team of long-term care residents. Participants were asked to review and complete a survey regarding clinical applicability of the guideline. Thirty-one interdisciplinary members participated in the education session and 30 surveys were received. Overall, the interdisciplinary team members agreed or strongly agreed the guideline was clinically applicable. Finally, the guideline was evaluated by a group of doctoral prepared practicing nurse practitioners using the AGREE II instrument. The scores were >80% in every domain, with an overall score of 91%, indicating the guideline is high in quality. Development of this guideline signifies an initial step in the management and prevention of constipation in the LTC resident.
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Werth, Barry Lewis. "Constipation and Laxative Use in the Community." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21314.
Introduction Constipation is a common health problem, often self-diagnosed and self-managed with laxatives without healthcare professional involvement. To improve diagnosis and management, it is important to understand constipation prevalence, associated factors, and laxative utilisation among community-dwelling adults. Aim The research aimed to determine the prevalence of constipation and laxative use, to investigate factors associated with constipation and describe laxative utilisation in Australia. Methods The first part explored constipation and laxative use in the general adult population. A cross-sectional survey was conducted online using a large nationally representative sample. The study focused on constipation prevalence, associated factors and laxative utilisation as well as examining the impact of constipation definitions on prevalence. The second part explored constipation and laxative use in an older adult cohort. Using Australian Longitudinal Study of Ageing data, the prevalence of constipation, associated factors and laxative use were examined over time. Results The online survey was completed by 2,024 participants. The constipation definition had considerable impact on prevalence estimates. As per Rome III criteria, 24% of participants had chronic constipation. Ten factors were significantly associated with it. One third (37%) reported using laxatives for either constipation treatment or prevention with 56% using laxatives recommended by healthcare professionals. In the older adult study, 239 participants were followed for 11 years. Self-reported constipation (14% to 21%) and laxative use (6% to 15%) increased over this period. Conclusion Constipation and laxative use are common among community-dwelling adults. Increased healthcare professional involvement in diagnosis and management, particularly laxative choice and use, may improve health outcomes. Development of guidelines addressing laxative use for both treatment and prevention should be considered.
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McCrea, G. Lindsay. "Gender and age differences in constipation characteristics, bowel symptoms, and bowel and dietary habits in patients evaluated for constipation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311335.
Aging, National Institute on, ed. Concerned about constipation? [Bethesda, Md.]: National Institute on Aging, U.S. Dept. of Health and Human Services, National Institutes of Health, 2005.
Beery, Renée M. Marchioni, and Reena V. Chokshi. "Overview of Constipation." In Constipation, 1–20. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_1.
Costilla, Vanessa C., and Amy E. Foxx-Orenstein. "Overview of Testing of Motility and of the Anorectum." In Constipation, 21–39. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_2.
Sura, Siddharth P., and Jennifer Christie. "Chronic Constipation." In Constipation, 41–65. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_3.
Everhart, Kelly K., and Brian E. Lacy. "Irritable Bowel Syndrome with Constipation." In Constipation, 67–95. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_4.
Wald, Arnold. "Colonic Inertia and Megacolon." In Constipation, 97–107. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_5.
Erdogan, Askin, and Satish S. C. Rao. "Pelvic Floor Dysfunction." In Constipation, 109–31. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_6.
Rose, Suzanne. "Constipation and Special Considerations: The Elderly, Children, Pregnancy, Spinal Cord Injury, Metabolic Disorders and Systemic Diseases, Opioid-Induced, and History of Abuse." In Constipation, 133–57. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_7.
Rose, Suzanne. "Putting It All Together." In Constipation, 173–76. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0332-0_9.
Moreira, Hélio, Joffre M. de Rezende, Hélio Moreira, and José Paulo T. Moreira. "Chagasic Megacolon." In Constipation, 235–46. London: Springer London, 2006. http://dx.doi.org/10.1007/978-1-84628-275-1_25.
Pinheiro, Amanda Pereira Sindeaux, Pedro Vitor Ferreira Rodrigues, Raoni de Oliveira da Silva Domingues, and Leonardo José Rodrigues de Araújo Melo. "Manometry viability for Parkinson’s disease constipation assessment." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.465.
Introduction: Parkinson’s Disease (PD) is a condition in wich the dopamine presence is lowered, causing motor and non-motor symptoms. Constipation of different severities is related to the pathogenesis of PD and is a common affection before the onset of disease. Despite these factors, there is a lack of specific diagnostic tools for the assessment of this symptom in PD, which difficults pathophysiological evaluation of constipation in those with PD or refractory constipation. Objectives: Identify if the findings in anorectal manometry could determine the existence of PD and be included in the examination process of patients with history of constipation. Methods: A systematic literature review was performed through an advanced search on Pubmed engine, in which 21 articles with the descriptors “anorectal” AND “manometry” AND “Parkinson” were selected. Results: Using anorectal manometry, it was detected that patients with PD constipation and functional constipation have dysmotility of the colon and rectum, but there are certain differences in segmental colonic transit time and rectal anal pressure between the groups. Compared with idiopathic constipation, anal sphincter pressures on voluntary squeeze were lower in the PD patients. Furthermore, defecatory dysfunction is found early in the course of the disease additionally to later stages. Conclusion: The use of manometry allows quantitative analysis of anorectal dysfunctions and provides early recognition of pelvic floor dyssynergy and colorectal assessment in PD. Besides, the findings in PD constipation are distinguishable from the findings in other types of constipation and in conditions of normalcy. Therefore, anorectal manometry could be used in the examination of patients with history of constipation in order to facilitate early recognition. In order to incorporate this practice, there is a need for more studies comparing the findings in PD and in other types of constipation.
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O’Neill, Sarah, Nicholas Wilson, Alexandra Kent, and Bu’Hussain Hayee. "P376 Developing a constipation service – what is the real cost of constipation?" In Abstracts of the BSG Campus, 21–29 January 2021. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2021. http://dx.doi.org/10.1136/gutjnl-2020-bsgcampus.450.
"NOVEL THERAPEUTIC AGENTS IN CONSTIPATION." In PUBLIC COMMUNICATION IN SCIENCE: PHILOSOPHICAL, CULTURAL, POLITICAL, ECONOMIC AND IT CONTEXT. European Scientific Platform, 2020. http://dx.doi.org/10.36074/15.05.2020.v3.21.
Bingham, Carly, Michalis Papadopoulos, and Mohamed Mutalib. "G3 Dyssynergia and chronic constipation." In Abstracts of the BSPGHAN Annual Meeting, 25–27 April 2022. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/flgastro-2022-bspghan.22.
Gordon, K. "G14 Is lockdown good for constipation?" In Abstracts of the BSPGHAN Annual Meeting, 25–27 April 2022. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/flgastro-2022-bspghan.33.
Ruffle, James, Linda Tinkler, Christopher Emmett, Alex Ford, Parashkev Nachev, Qasim Aziz, Adam Farmer, and Yan Yiannakou. "P342 Constipation-predominant irritable bowel syndrome and functional constipation are not discrete disorders: a machine learning approach." In Abstracts of the BSG Campus, 21–29 January 2021. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2021. http://dx.doi.org/10.1136/gutjnl-2020-bsgcampus.416.
Sinopoulou, Vassiliki, Morris Gordon, Shaman Rajindrajith, and Marc Benning. "G29 Treatments for intractable constipation in childhood." In Abstracts of the BSPGHAN Annual Meeting, 25–27 April 2022. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/flgastro-2022-bspghan.49.
Rosyida, Muslihatin Khuril. "ACUPUNCTURE THERAPYY TO REDUCE CONSTIPATION: META-ANALYSIS." In The 8th International Conference on Public Health 2021. Masters Program in Public Health, Universitas Sebelas Maret, 2021. http://dx.doi.org/10.26911/ab.medicine.icph.08.2021.24.
Milošić, Katarina, Mirna Natalija Aničić, Lana Omerza, Irena Senečić-Čala, Jurica Vuković, and Duška Tješić-Drinković. "P605 Functional constipation in a tertiary hospital setting." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.937.
Xie, Li, and Ci-Song Cheng. Probiotics in the treatment of senile constipation: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0070.
Review question / Objective: Is probiotic therapy as effective or more effective than existing treatments in relieving the severity of constipation and improving the patient's mental status and quality of life in elderly patients with constipation? Do probiotic treatments pose greater risks than existing treatments for older patients with constipation? Condition being studied: Constipation is a common digestive disorder with a worldwide prevalence of 14-30%, and the prevalence increases with age. Constipation seriously impairs patients' quality of life, leads to significant medical costs, and places a burden on the healthcare system. For constipation, Western medicine uses lifestyle changes, medication, psychotherapy, biofeedback, and surgery to treat the condition.
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Ni, Jiachun, Qiong Jiang, Gang Mao, Yi Yang, Qin Wei, Changcheng Hou, Xiangdong Yang, Wenbin Fan, and Zengjin Cai. The effectiveness and safety of acupuncture for constipation associated with Parkinson’s disease: Protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0091.
Review question / Objective: Is acupuncture a safe and effective therapy for constipation associated with Parkinson’s disease? Our aim is to assess the effectiveness and safety of acupuncture for constipation associated with PD and give guidance to future research direction. Condition being studied: Parkinson’s disease (PD) is a prevalent degenerative disease of nervous system characterized mainly by static tremor, bradykinesia, myotonia, postural gait disorders and other non-motor symptoms. According to variations on race, ethnicity, age and sex, the incidence of PD ranges from 8 to 20.5 per 100, 000 individuals annually. One global research shows that there were 6.1 million individuals suffer from PD in 2016 and will be 12 million patients around the world. According to several outcomes of case-control studies, the prevalence of constipation in PD varies from 28% to 61%. Constipation, as a common gastrointestinal disease which refers to the clinical presentation of reduced spontaneous complete bowel movement, dyschezia, feeling of incomplete defecation and outlet obstruction, is demonstrated to antedate the motor symptom and it's severity is related to the progression of PD. Acupuncture has been proved to act on the pathogenesis of constipation associated with PD. The proposed systematic review we're about to present is the first advanced evidence-based medical evidence in this area.
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Ding, Fei, Ying-ying Meng, and Shi Liu. Efficacy and Safety of Secretagogues in Irritable Bowel Syndrome With Constipation and Functional Constipation: a Network Meta-analysis of RCTs in Adult Patients. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0044.
Zheng, You-you, Ning Liang, Long-kun Liu, Wei-jia Sun, Xue-hui Wang, Yu-xin Sun, Yun-ru Chen, Xiao-xia Han, Zhao-lan Liu, and Jian-ping Liu. Effectiveness and Safety of Chinese Patent Medicine for Functional Constipation: A Systematic Review and Network-Meta Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0049.
Review question / Objective: To evaluate the effectiveness and safety of Chinese patent medicine in treatment of functional constipation by using the Network Meta-Analysis. 1. Types of participants: participants diagnosed as functional constipation according to Rome III, Rome IV or other published criteria or guidelines. No limitation on types of FC, age, sex, and nation. Children and pregnant women were excluded. Participants who had other constipation-related diseases including irritable bowel syndrome, functional defecation disorders and opioid-induced constipation were excluded. 2 Types of Interventions. Chinese patent medicine which have been registered with the approval batch number beginning with “Z,” approved by Chinese National Medical Product Administration (NMPA), used alone or in combination with Polyethylene Glycol, Lactulose, Bisacodyl, Prucalopride Succinate, probiotic, or Mosapride which recommended by latest clinical guidelines released by authorized organizations. The dosage, formulation, and route of administration of Chinese patent medicine were not limited. 3 Types of control. Registered Chinese patent medicines used alone, Polyethylene Glycol, Lactulose, Bisacodyl, Prucalopride Succinate, probiotic, Mosapride which recommended by latest clinical guidelines released by authorized organizations or placebo were eligible. 4 Types of outcomes. Primary outcomes were the clinical effect, score of dyschezia and defecation time. Secondary outcomes were adverse events and recurrence rate. 5 Types of study design. Parallel randomized controlled trials (RCTs) were included. Conference abstracts were excluded if full articles were not available.
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Chiarioni, Giuseppe, Stefan Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, and Teodora Surdea-Blaga. Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2023. http://dx.doi.org/10.37766/inplasy2023.8.0108.
Yang, Pu, Yuanchun Wang, Yingchun Xiao, Qiaolin Ma, Runhong Ma, Jing Mi, and Jianrong Hui. Acupuncture for opioid-induced constipation: Protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2020. http://dx.doi.org/10.37766/inplasy2020.10.0026.
Jingui, wang. Massage for constipation in patients with stroke: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0061.
Cui, Sufen. Acupuncture for chronic constipation in patients with diabetes mellitus: a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0079.
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