Готові списки джерел за темами / Congenital heart diseases (CHD)

Добірка наукової літератури з теми "Congenital heart diseases (CHD)"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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Статті в журналах з теми "Congenital heart diseases (CHD)"

1

Martins, Cristiane. "Congenital heart disease." Clinical Cardiology and Cardiovascular Interventions 3, no. 11 (November 20, 2020): 01–02. http://dx.doi.org/10.31579/2641-0419/097.

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2

Mamun-ur-Rashid, Al, Mohammed Zaglul Hai Russeel, and Md Belayet Hossain Akanda. "Congenital Heart Diseases among Children in Selected Hospital." Journal of Clinical and Laboratory Research 5, no. 2 (January 14, 2022): 01–05. http://dx.doi.org/10.31579/2768-0487/066.

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Анотація:
Background: Congenital heart disease (CHD) is the most common type of birth defect. As CHD accounts for the most frequent cause of lethal malformation among infants, CHD is also considered a major problem affecting public health worldwide. Objective: To assess pattern of congenital heart diseases and associated risk factors among under-14 children admitted in a selected hospital. Methods: It was cross sectional analytical study conducted among purposively selected 111 children admitted in Children Hospital for treatment. Face to face interview was conducted to collect data. The cases were included in the study when the diagnosis of CHD was established by medical records and echocardiography. Results: About 91% and 9% children came from <1 year and 1-5 year age group. Low birth weight and normal birth weight was 52% and 48%. Pre-term and term distribution was 37% and 63%. About half of the respondents were middle class. About 26%, 25% and 18% mothers consumed vitamin A (>10000 IU/d), anti-pyretics and NSAIDs during pregnancy. About 40% mothers consumed contaminated tap water and 29% mothers were exposed to radiation. Ventricular septal defect (40.5%) and atrial septal defect (36.9%) were prominent. Patent ductus arteriosus and pulmonary stenosis were 8.1% and 5.4%. Statistical significant association was found between ventricular septal defect and birth weight, gestational age and monthly family income. As like VSD, atrial septal defect showed statistical significant association with birth weight, monthly family income, maternal age and rubella infection 6 months prior to conception or 1st trimester. Conclusion: Ventricular septal defect (40.5%) and atrial septal defect (36.9%) were common among children. Maternal nutrition during pregnancy should be emphasized due to prevent low birth weight and pre-term baby.
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3

Bakhru, Shweta. "Pregnancy in Congenital Heart Diseases." Indian Journal of Cardiovascular Disease in Women WINCARS 03, no. 02/03 (August 2018): 126–31. http://dx.doi.org/10.1055/s-0038-1676667.

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Анотація:
AbstractCongenital heart diseases (CHDs) affect 0.8 to 1.5% of general population. With increase in awareness and medical services, more number of patients with CHDs have entered into adulthood. One of the peculiar physiologic changes in women is going through pregnancy. Misconceptions are common in women with CHD. This write-up is to provide some brief information about CHD patients going through pregnancy. General cardiovascular risk and individual disease-related risks are discussed.
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4

Amroliwala, Rakesh, Manish Rasania, Raish Memon, Avina Pokharna, and Dixa Shah. "Study of congenital heart diseases in neonates." International Journal of Contemporary Pediatrics 5, no. 1 (December 21, 2017): 75. http://dx.doi.org/10.18203/2349-3291.ijcp20175541.

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Анотація:
Background: Congenital heart disease defined as an abnormality in cardio circulatory structure or function that is mostly present at birth; even it is discovered much later. Recognition of congenital heart disease in newborn is important as this group abnormality constitutes a significant proportion of congenital malformation that present in the neonatal life, and their early detection is important for appropriate management and good outcome. Objectives of present study were to evaluate clinical profile and outcome of various CHDs identified during neonatal period and to study effect of paracetamol used for pharmacological closure of PDA in preterm neonates.Methods: The study was conducted prospectively in NICU, Dhiraj hospital, Department of Pediatrics and Neonatology from January 2016 to June 2017 (1.5 years span). Echocardiography screening of all neonates suspected of having CHD was done. Details of all neonates having CHD diagnosed by echocardiography were noted in the prescribed Performa and their incidence, clinical profile and outcome was studied.Results: Total 69 cases of CHD diagnosed by Echocardiography in neonatal period were studied. Incidence of CHD among neonates born at Dhiraj hospital was 8.48 per 1000 live birth. Male: female ratio of all CHD cases was 1.38:1. Risk of neonate with CHD is highest (18.18%) in extremely low birth weight neonates. Incidence of CHD was 4.08% in preterm < 34 weeks, 3.47% in late preterms and 0.51% in full term neonates. 86.95% were diagnosed within first week of life. 26.09% babies had associated anomalies. Presenting problem of neonates was breathing difficulty 42 (60.87%), feeding difficulty 36 (52.17%) and cyanosis 5 (7.25%). 8 (11.59%) neonates were asymptomatic. The most common presenting sign was murmur 46 (75.71%). 56 (81.16%) had Acyanotic CHD and 13 (18.84%) had Cyanotic CHD. Amongst 56 (81.16%) Acyanotic CHD cases, commonest was PDA in 44 (78.5%), followed by VSD in 18 (32.14%), ASD in 5 (12.5%) either in isolation or in combination with other lesions. Amongst Cyanotic Congenital Heart Disease, maximum incidence was of Tricuspid Atresia (TA) in 4 (30.76%) cases; followed by TGA in 3 (23.07%). 20 preterm neonates with PDA received paracetamol for PDA closure. 9 (45.0%) responded to paracetamol while 11 (55%) did not respond. 47(68.12%) were discharged, 10(14.49%) went left against medical advice, 7(10.14%) were referred to higher centre for surgery and 5(7.25%) babies expired.Conclusions: Early recognition of congenital heart disease during neonatal life is important as its appropriate and timely management can result in good outcome.
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Khurram Shahnawaz, Farhan Zahoor, Bushra Madni, Muhammad Imran, Muhammad Naveed, and Fazal ur Rehman. "Pattern of paediatric congenital heart diseases." Professional Medical Journal 28, no. 11 (October 31, 2021): 1678–81. http://dx.doi.org/10.29309/tpmj/2021.28.11.6450.

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Анотація:
Objective: To find out pattern along with age and gender wise distribution of congenital heart disease (CHD). Study Design: Cross Sectional study. Setting: Department of Pediatrics, Sughra Shafi Medical Complex, Narowal. Period: January 2019 to February 2020. Material & Methods: During the study period, a total of 151 children aged between 1 month to 15 years as confirmed case of CHD according to echocardiography were enrolled for this study. Gender, age categories, area of residence and types of CHDs were represented as frequency and percentages. Patients with different types of CHDs were distributed between both gender and different age categories. SPSS version 26.0 was used to handle and analyze all study related data. Results: During the study period, a total of 151 confirmed cases of CHD were enrolled. There were 82 (54.3%) male and 69 (45.7%) female representing a male to female ratio of 1.2:1. Most of the cases were aged less than 1 year. There were 118 (78.1%) children below 1 year of age while 22 (14.6%) between 1 to 5 years of age and 11 (7.3%) above 5 years of age. Ventricular septal defect (VSD) and ASD were noted to be the most frequent types of acyanotic heart lesions in 41 (27.2%) and 29 (19.2%) cases respectively whereas TOF was the most frequent type of cyanotic heart lesion in 23 (15.2%) cases. Conclusion: VSD followed by ASD and TOF were noted to be the most frequent types of CHD.
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6

Ilyas, Sana, Sana Waqar, Asim Khurshid, and Muhammad Sohail Arshad. "Congenital heart diseases in premature newborns." Professional Medical Journal 28, no. 08 (August 1, 2021): 1178–82. http://dx.doi.org/10.29309/tpmj/2021.28.08.6126.

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Objective: To determine the frequency of congenital heart diseases (CHD) in newborns admitted with prematurity. Study Design: Descriptive Cross Sectional study. Setting: Department of Pediatric Neonatology Children’s Hospital & The Institute of Child Health, Multan. Period: August 2019 to January 2020. Material & Methods: A total of 155 preterm infants ≤36 weeks gestation were included. In preterm newborns of either gender, echocardiography was done by hospital Pediatric Cardiologist. Patient’s name, age, gestational age, weight, sex, date, serial number, registration number and echocardiographic results were entered in pre-designed performa. The outcome variable was frequency of congenital heart disease in preterm newborns. Results: Congenital heart disease was detected in 34.8% (n = 54) preterm infants. Nine percent (n=14) were < 1.5 kg, 45.2% (n=70) between 1.5 – 2.0 kg and 45.8% (n=71) were > 2.0 kg in weight. Most frequent lesion was Ventricular Septal Defect (VSD) in 19 (35%) infants followed by patent ductus arteriosus (PDA) in 15 (28%) infants. Atrial Septal Defect (ASD) was seen in 6 (11%) preterm infants. Frequency of CHD was significantly higher (p-value < 0.001) in babies delivered at ≤32 weeks and those infants with with birth weight <1.5 kg. Conclusion: The study highlights the association of congenital heart diseases in premature and low birth weight neonates. So, every preterm and low birth weight neonate must undergo echocardiography to screen for CHD so that earlier diagnosis may be made for earlier intervention.
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Nnomzo’o, Alice, Pavel V. Pavlov, Ekaterina S. Garbaruk, Oksana C. Gorkina, and Olga S. Olina. "The auditory function of infants with congenital heart diseases." Pediatrician (St. Petersburg) 8, no. 3 (May 15, 2017): 81–87. http://dx.doi.org/10.17816/ped8381-87.

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Анотація:
Congenital heart disease (CHD) is 1/3 of all congenital malformations and one of the main causes of infant mortality. Hearing loss may be part of syndromes associated with CHD, or the hearing pathology can be a consequence of the various stages of rehabilitation of underlying pathology. Currently, there isn’t any data on the systematic study of hearing impairment in children with congenital cardiac pathologies. Three hundred and six patients aged 2 days to 8.5 months were examined: 96 patients were included in the main group with CHD, and 300 children without CHD made up a comparison group. All children underwent newborn hearing screening. Infants with suspected hearing pathology were tested with a comprehensive audiological examination. In the CHD group hearing impairment was detected in 29% of children, including sensorineural hearing loss (SNHL) in 12%. And in the comparison group, 3.6% of infants had a hearing loss, SNHL was defined in 1%. Analysis of the data revealed the most significant risk factors for hearing impairments in children with CHD and it had showed the difference in the structure of the risk factors between the both groups. In the study group was registered a case of auditory neuropathy spectrum disorders. This case illustrated the importance of conducting hearing screening by means of click-evoked auditory brainstem responses and not only of registration of otoacoustic emissions. One child with CHD was found to have delayed SNHL, which requires long-term monitoring of hearing in children with cardiopathology.
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Wijnands, K. P. J., S. A. Obermann-Borst, E. J. G. Sijbrands, M. F. Wildhagen, W. A. Helbing, and R. P. M. Steegers-Theunissen. "Cardiovascular diseases in grandparents and the risk of congenital heart diseases in grandchildren." Journal of Developmental Origins of Health and Disease 5, no. 2 (February 19, 2014): 152–58. http://dx.doi.org/10.1017/s2040174414000026.

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Анотація:
Hyperglycemia, dyslipidemia and hyperhomocysteinemia are associated with both adult cardiovascular disease (CVD) and having a child with a congenital heart disease (CHD). We investigated associations between CVD in grandparents and the risk of CHD in grandchildren. In a case–control family study, we obtained detailed questionnaire information on CVD and CHD in 247 families with a CHD child and 203 families without a CHD child. Grandparents with CVD or intermittent claudication (IC) were significantly associated with an increased risk for CHD in grandchildren [OR 1.39 (95% CI 1.03–1.89) and OR 2.77 (95% CI 1.02–7.56), respectively]. The risk of CHD grandchildren was particularly increased in paternal grandfathers with CVD [OR 1.85 (95% CI 1.01–3.37)]. Overall, having a grandparent with CVD increased the risk for CHD in the grandchild by 1.65 (95% CI 1.12–2.41). After adjustment for potential maternal confounders, this risk was 1.44 (95% CI 0.94–2.21). Having two or more grandparents with CVD was associated with an approximately threefold risk for CHD grandchildren [OR adjusted 2.72 (95% CI 1.08–6.89)]. Our data suggest that CVD and IC in grandparents are associated with an increased risk of having a CHD grandchild. These first findings may be explained by shared causality of derangements in metabolic pathways and are in line with the fetal origins of health and disease.
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Akhmedova, Irina, Gulzada Imanalieva, Damirbek Abibillaev, and Taalaibek Kudaiberdiev. "Primary detection of congenital heart diseases in the Kyrgyz Republic." Heart, Vessels and Transplantation 2, Issue 2 (June 3, 2018): 56. http://dx.doi.org/10.24969/hvt.2018.66.

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Objective: The aim of this paper is to understand the structure of congenital heart diseases (CHD) and the age of the first diagnosis in a population referred to specialized cardiac surgery center from different regions of Kyrgyz Republic. Methods: In 2017, 7213 people of different ages, from Kyrgyz Republic were examined by using transthoracic echocardiogram at cardiac surgery center aimed to detection of congenital heart disease Results: In total, 478 new patients with primary diagnosis of CHD were identified; 413 (86%) patients had a delayed diagnosis. The total detectability was 6.75%. The structure of congenital heart disease has a large difference depending on the age group. The proportion of complex heart defects predominates in newborn children and significantly decreases with age. Conclusion: A study of the prevalence and structure of heart defects in the country will help to find the right decision in planned care for patients with CHD, in cases of limited resources. Keywords: newborn, congenital heart defects, diagnostics, prevalence, echocardiography
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10

Wu, Yue, Xiaosi Jin, Yuhao Zhang, Jing Zheng, and Rulai Yang. "Genetic and epigenetic mechanisms in the development of congenital heart diseases." World Journal of Pediatric Surgery 4, no. 2 (April 29, 2021): e000196. http://dx.doi.org/10.1136/wjps-2020-000196.

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Анотація:
Congenital heart disease (CHD) is the most common of congenital cardiovascular malformations associated with birth defects, and it results in significant morbidity and mortality worldwide. The classification of CHD is still elusive owing to the complex pathogenesis of CHD. Advances in molecular medicine have revealed the genetic basis of some heart anomalies. Genes associated with CHD might be modulated by various epigenetic factors. Thus, the genetic and epigenetic factors are gradually accepted as important triggers in the pathogenesis of CHD. However, few literatures have comprehensively elaborated the genetic and epigenetic mechanisms of CHD. This review focuses on the etiology of CHD from genetics and epigenetics to discuss the role of these factors in the development of CHD. The interactions between genetic and epigenetic in the pathogenesis of CHD are also elaborated. Chromosome abnormalities and gene mutations in genetics, and DNA methylations, histone modifications and on-coding RNAs in epigenetics are summarized in detail. We hope the summative knowledge of these etiologies may be useful for improved diagnosis and further elucidation of CHD so that morbidity and mortality of children with CHD can be reduced in the near future.
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Більше джерел

Дисертації з теми "Congenital heart diseases (CHD)"

1

Grech, Victor. "Congenital heart disease in Malta." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286359.

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2

Lipscomb, Sund Kristen. "Adults with Congenital Heart Disease: A Genetic Perspective." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1252702239.

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3

Granbom, Elin. "Respiratory tract infections in children with congenital heart disease." Licentiate thesis, Umeå universitet, Pediatrik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128024.

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Respiratory Syncytial Virus (RSV) infection is common among young children. Congenital Heart Disease (CHD) is a risk factor of severe illness and hospitalization. Palivizumab prophylaxis reduces the severity of RSV infection and reduces the risk of hospitalization for children at high risk of severe illness, such as children born premature or with CHD. The aim of this thesis was to evaluate compliance with national guidelines for prophylactic treatment and to study the Relative Risk (RR) of hospitalization due to RSV and unspecified Respiratory Tract Infection (RTI) for children with CHD. In a prospective study, questionnaires were sent to all paediatric cardiology centres in Sweden with questions about prophylactic treatment. Hospitalization rates were retrieved from the national inpatient registry. Heart defects were grouped according to type and the relative risk of hospitalization was calculated for each group and for summer and winter seasons. Half of the patients received prophylactic treatment later than recommended in the guidelines. The risk of hospitalization due to RSV infection was increased (RR=2.06 95% CI 1.6-2.6; p < 0.0001) for children with CHD compared to children without CHD. The RR of hospitalization was also increased for all CHD subgroups, and was further increased during summer for children with the more severe CHD. We conclude that guidelines for prophylactic treatment were not followed and that the risk of hospitalization due to RSV and unspecified RTI was increased for all subgroups of CHD. The risk was increased both during winter and summer and we therefore argue that information to health personnel and parents should include that the risk of severe RTI is present all year round for children with CHD.
Respiratoriskt syncytialvirus (RSV) är det vanligaste förkylningsviruset och de allra flesta barn drabbas före två års ålder. RSV kan leda till allvarlig luftvägsinfektion hos alla barn, men speciellt hos dem med medfött hjärtfel. Någon botande läkemedelsbehandling finns inte för RSV, utan de medicinska insatserna får inriktas mot att mildra sjukdomsförloppet och för svårt sjuka barn krävs sjukhusvård för att exempelvis erhålla syrgasbehandling. Det finns inget vaccin mot RSV, men barn som riskerar att bli svårt sjuka kan behandlas profylaktiskt med en monoklonal antikropp (Palivizumab) som ges som injektion en gång per månad under vintersäsong. Vissa barn med svårt hjärtfel får denna profylaktiska behandling enligt nationella riktlinjer. Vår första studie visade att ungefär hälften av barnen med medfött hjärtfel, aktuella för profylax mot RSV, fick behandlingen senare än vad de nationella riktlinjerna rekommenderade. Denna studie genomfördes via en enkät till alla landets barnkliniker under två vintersäsonger. Vi såg även att något fler barn än förväntat (4.6%) fick RSV-infektion trots profylaktisk behandling och för cirka en tredjedel av dessa barn fördröjdes tiden till hjärtoperation. Behovet av sjukhusvård kan användas som mått på hur svårt ett sjukdomsförlopp är, och baserat på Socialstyrelsens slutenvårdsregister studerade vi alla barn under två års ålder och fann att den relativa risken för sjukhusvård på grund av RSV var högre för barn med hjärtfel än för barn utan hjärtfel (RR=2.06 95% CI 1.6-2.6; p < 0.0001). I vår andra studie, baserad på slutenvårdsregistret, beräknade vi den relativa risken för sjukhusvård på grund av RSV, för barn med olika former av hjärtfel och uppdelat i sommar- och vintersäsong. Risken för sjukhusvård var ökad för alla barn oavsett typ av hjärtfel, och detta gällde såväl under vintern som under sommaren. Barn med de allvarligaste formerna av hjärtfel hade högre risk för sjukhusvård under sommaren jämfört med deras risk under vintern, medan barn med vad som anses vara lättare hjärtfel hade ökad risk för sjukhusvård under hela året, utan någon större skillnad i risk mellan vinter och sommar. Att barn med hjärtfel riskerar att bli svårt sjuka i RSV är väl känt, men våra resultat visar att denna risk även existerar under sommarhalvåret, då det inte är RSV-säsong och då profylax inte ges. Vi fann också att barn med vad som anses vara lättare hjärtfel löper lika stor risk att drabbas av svårare sjukdomsförlopp med sjukhusvård under vintern, som barn med svårare hjärtfel. Att denna information sprids till såväl sjukvårdspersonal som arbetar med denna patientgrupp som till föräldrar med hjärtsjuka barn är viktigt, för att belysa att även dessa barn behöver skyddas, och detta inte bara under vintern och RSV-säsongen.
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4

Erdenebileg, Ariuntsatsral Ariunaa. "Is Maternal Headache a Risk Factor for Congenital Heart Disease?" Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/iph_theses/70.

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Анотація:
Congenital Heart Disease (CHD) is one of the most common birth defects. It is the single most modifiable cause of infant mortality under one year of age. Therefore, the causes of CHD have been extensively researched in the past but the etiology remains largely unknown. Environmental risks, particularly maternal risk factors for congenital cardiac malformation have been evaluated in the original BWIS previously. However, in this research we examined one of the additional risk factors. We sought to determine whether maternal headache during six months prior to conception and throughout gestation until birth is a risk factor for CHD in the BWIS dataset. Among 3274 singleton cases and 3519 controls, a maternal report of headache was found to be associated with a nearly 20% increase in the risk of a congenital heart defect (OR= 1.2 p=0.001). Moreover, any medications use for headache 1-6 months prior to conception increased the risk of abnormal cardiac development by 1.3 fold (OR = 1.3, p=0.0004). Aspirin or aspirin containing analgesics were found to increase the risk for CHD at the defined risk period. According to subgroup analysis, aspirin or aspirin containing analgesics and acetaminophen or acetaminophen containing analgesics were found to be the risk factor for CTD i.e. Conotruncal defects. Furthermore, aspirin or aspirin containing analgesics increased the risk for PVSD i.e. Peri-membranous Ventricular Defect in offspring when the mother uses these drugs 1-6 months prior to conception. Additionally, the risk for CVD i.e. critical valve disease were found to be increased when women were exposed to aspirin or aspirin containing analgesics during third trimester after pregnancy. In conclusion, maternal headache increased the risk for CHD by 20% and the use of headache medications specifically pain relievers during 1-6 months prior to conception modulated type of defect was observed.
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5

Garris, Theresa. "Investigation of Self-reported Transitional Health Care Needs of the Adolescent with Congenital Heart Disease." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1164036105.

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6

Schiele, Steven E. "The Influence of Disease Knowledge and Illness Uncertainty on Psychological Distress and Quality of Life in Patients with Congenital Heart Disease." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492787611693681.

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7

Olsson, Annie, and Nathalie Hurtig. "Unga vuxnas upplevelser av att leva med medfött hjärtfel." Thesis, Högskolan Väst, Avdelningen för omvårdnad - grundnivå, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-9500.

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Анотація:
Background: Approximately 1000 children with a congenital heart disease are born in Sweden each year. Congenital heart diseases include malformations of the heart which comprise various anatomical differences. Progresses in diagnostics and treatment of the cardiac diseases have contributed to the survival of these young adults which makes a new and growing group of patients. Aim: The aim of this study was to describe young adults' between the ages of 13-40 experiences of living with congenital heart disease. Method: A literature study based on qualitative studies from Cinahl and PubMed was performed. Ten articles were analyzed by content analysis. Results: The results of the study present two main categories "accept one's heart disease" and "challenge to accept one's heart disease" with a total of ten subcategories. Conclusion: Individuals with congenital heart disease may experience their situation in various ways and they may or may not have accepted their congenital heart disease. Some individuals feel that the disease contributes to personal strength, while others are living with a constant presence of anxiety over the fact that life can change for the worse at any time.
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8

Cohen, Sarah. "Apport et utilisation des bases de données médico-administratives dans l’étude des problématiques émergentes chez les patients adultes atteints de cardiopathie congénitale Administrative health databases for addressing emerging issues in adults with CHD: a systematic review Accuracy of claim data in the identification and classification of adults with congenital heart diseases in electronic medical records Exposure to low-dose ionizing radiation from cardiac procedures and malignancy risk in adults with congenital heart disease." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB228.

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Les cardiopathies congénitales (CC) sont les plus fréquentes des malformations congénitales et concernent près de 1% des naissances. Grâce aux progrès considérables de la cardiologie pédiatrique et de la chirurgie cardiaque, 90% des enfants nés avec une CC atteignent désormais l'âge adulte. Mais ces « survivants » ne sont pas guéris. Un certain nombre de complications, cardiaques et extracardiaques, attendues ou non, et de problématiques spécifiques émergent, justifiant une consommation de soins grandissante. Le besoin d’études en population a motivé l’analyse secondaire de données médico-administratives dans diverses régions du globe. L’objectif de cette thèse était d’étudier les conditions d’utilisation des bases de données médico-administratives (BDMA) et leurs applications possibles pour mieux comprendre les enjeux émergents de cette population nouvelle d’adultes avec CC (ACC). La première partie de ce travail a été de décrire de manière systématique toutes les études ayant utilisé des BDMA pour explorer spécifiquement les problématiques des patients ACC. Cette revue a montré l’intérêt de ces bases de données dans le domaine des ACC, les effectifs importants permettant d’étudier des maladies relativement rares et la disponibilité de données exhaustives sur de longues périodes d’observation autorisant l’étude de certaines complications cardiaques ou extracardiaques de survenue parfois différée chez ces patients. En France, les bases de données administratives de remboursement utilisent la Classification internationale des Maladies, dixième révision (CIM-10) dont la fiabilité pour repérer les ACC et les pathologies qui leur sont associées est inconnue dans ce contexte. La deuxième partie de ce travail avait donc pour objectif d’étudier la performance de la CIM-10 pour identifier et classer des patients ACC au sein de l’entrepôt de données de l’hôpital Européen Georges Pompidou disposant d'une unité dédiée aux ACC. La troisième partie de cette thèse rapporte un exemple concret de l’utilisation des BDMA. A partir des données de la Québec Congenital Heart Disease Database issue des BDMA du Québec, notre objectif était d’évaluer l’association entre l’exposition aux rayonnements ionisants provenant de procédures cardiaques et la survenue de cancer chez les ACC. En effet, l’amélioration de l’espérance de vie des patients avec CC et l’augmentation du recours aux modalités d’imagerie cardiaque irradiante, font craindre un effet carcinogène potentiel à long terme. Bien qu’elles n’aient pas été conçues à des fins de recherche, ce travail de thèse montre que les BDMA sont un outil particulièrement pertinent pour générer de nouvelles connaissances sur les patients ACC de par l’exhaustivité des informations disponibles, la possibilité de produire de grands échantillons et de permettre un suivi longitudinal sur de longues périodes d'observation. L’exploitation des dossiers médicaux électroniques par des méthodes de fouilles de texte pourrait alors permettre de développer et valider des algorithmes pour identifier les cas de CC dans les BDMA. En France, bien que des efforts aient été déployés pour créer un programme de collaboration multicentrique efficace, il n’existe à l’heure actuelle aucune donnée épidémiologique d’envergure concernant l’ensemble des ACC. L’analyse secondaire de ressources existantes, telles que le Système National des Données de Santé, permettrait d’établir la cohorte nationale d’ACC et d’analyser leur parcours de soins afin d’orienter au mieux l’allocation des ressources
Congenital heart diseases (CHD) are the most common types of birth defects and affect approximately 1% of births. Ninety percent of children born with CHD reach now adulthood thanks to improvements of pediatric cardiology and cardiac surgery. These "survivors" are not definitively cured. They are prone to cardiac or extra cardiac complications and specific issues that justify an increase in consumption of healthcare. The need for population-based studies worldwide has led to secondary analyses of administrative medical databases (AMD). The objective of this thesis was to study the conditions of use of the AMD and their possible applications, specifically to understand the emerging issues of this new adult population with CHD (ACHD). The first part of this work was to systematically describe all the studies that had used AMD to specifically explore the issues of ACHD patients. This review showed the value of these databases in the field of ACHD: the large numbers of patients allows studying relatively rare diseases and the availability of comprehensive data over long periods of follow-up enables to study cardiac and extra cardiac complications even when the occurrence is delayed. In France, claim databases use the International Classification of Diseases, 10th revision (ICD-10), the reliability of which is still largely unknown in this context. The second part of this work was therefore to study the performances of ICD-10 to identify and classify ACHD patients in the data warehouse of the Georges Pompidou European Hospital which has a dedicated specialized ACHD Unit. The third part of this thesis reported a concrete example of the use of AMD. Based on the Quebec Congenital Heart Disease Database derived from Quebec’s AMD, our goal was to evaluate the association between exposure to ionizing radiation from cardiac procedures and the risk of cancer in ACHD. Indeed, the improvement in the life expectancy of patients with CHD and the increasing use of cardiac imaging modalities using ionizing radiations may have a carcinogenic effect in the long term. Although not designed for research purposes, this thesis showed that AMD are a particularly relevant tool for generating new knowledge about ACHD patients through the comprehensiveness of information, the possibility of extracting large samples of patients with a longitudinal follow-up over long periods of observation. The exploitation of electronic medical records through text mining methods could then be used to develop and validate algorithms to identify CHD patients in AMD. In France, although efforts have been made to create an effective multi-center collaborative program, there is currently no significant epidemiological data for all ACHDs. Secondary analysis of existing resources, such as the National Health Data System, would establish the national ACHD cohort and analyze their care pathway in order to guide healthcare resources allocation
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Saied, Hala. "Stress coping, social support and adjustment among families of chd children in Picu after heart surgery." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1152694720.

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Darwich, Rami. "Functional Analysis of KLF13 in the Heart." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34317.

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Congenital heart defects (CHD) are the largest class of birth defects in humans and are a major cause of infant mortality and morbidity. Deciphering the molecular and genetic etiologies central for heart development and the pathogenesis of congenital heart diseases (CHD) is a challenging puzzle. We have previously demonstrated that the zinc-finger kruppel-like transcription factor KLF13, expressed predominantly in the atria, binds evolutionarily conserved regulatory elements known as CACC-boxes and transcriptionally activates several cardiac promoters. KLF13 loss of function in Xenopus embryos was associated with cardiac developmental defects underscoring its critical role in the heart. In the current study, using in vivo and in vitro approaches, we examined KLF13’s mechanisms of action and its interaction with other cardiac regulators. To test the evolutionary conserved role in the mammalian heart, we deleted the Klf13 gene in transgenic mice using homologous recombination. Mice with homozygote deletion of Klf13 were born at reduced frequency owing to severe heart defects. We also report the existence of a novel isoform of KLF13, referred to here as KLF13b. Furthermore, we report that KLF13 interacts biochemically and genetically with the T-box transcription factor TBX5 which is a key regulator of heart development. Our data provide novel insight into the role of KLF13 in cardiac transcription and suggest that KLF13 maybe a genetic modifier of congenital heart disease. Furthering our knowledge of protein-protein interactions and gene transcription will enhance genotype-phenotype correlation and contribute to better understanding of the etiology of CHD.
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Книги з теми "Congenital heart diseases (CHD)"

1

Rickert-Sperling, Silke, Robert G. Kelly, and David J. Driscoll, eds. Congenital Heart Diseases: The Broken Heart. Vienna: Springer Vienna, 2016. http://dx.doi.org/10.1007/978-3-7091-1883-2.

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2

Ley, Sebastian, and Julia Ley-Zaporozhan, eds. Congenital Heart Diseases in Adults. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-61888-3.

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3

Redington, Andrew N., Glen S. Van Arsdell, and Robert H. Anderson, eds. Congenital Diseases in the Right Heart. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84800-378-1.

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4

H, Anderson Robert, Van Arsdell Glen S, and SpringerLink (Online service), eds. Congenital Diseases in the Right Heart. London: Springer London, 2009.

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5

A, Reitz Bruce, and Yuh David D, eds. Congenital cardiac surgery. New York: McGraw-Hill Medical Pub. Div., 2002.

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6

Rajeshkannan, Ramiah, Vimal Raj, and Sanjaya Viswamitra, eds. CT and MRI in Congenital Heart Diseases. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-6755-1.

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7

Congenital diseases of the heart: Clinical-physiological considerations. 3rd ed. Chichester, West Sussex, UK: Wiley-Blackwell, 2009.

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8

C, Marshall Audrey, Meadows Jeffery, Foerster Susan, and SpringerLink (Online service), eds. Congenital Heart Disease: The Catheterization Manual. Boston, MA: Springer US, 2008.

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9

Butera, Gianfranco, John Cheatham, Carlos AC Pedra, Dietmar Schranz, and Gerald Tulzer, eds. Fetal and Hybrid Procedures in Congenital Heart Diseases. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40088-4.

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10

Tagarakis, Georgios, Ahmed Gheni Sarfan, Hashim Talib Hashim, and Joseph Varney, eds. Clinical and Surgical Aspects of Congenital Heart Diseases. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23062-2.

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Частини книг з теми "Congenital heart diseases (CHD)"

1

Isgrò, Giuseppe, and Simona Silvetti. "Respiratory System and Mechanical Ventilation in Patients with CHD." In Congenital Heart Disease, 163–75. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78423-6_9.

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Rajeshkannan, Ramiah. "Sequential Segmental Approach to CHD." In CT and MRI in Congenital Heart Diseases, 107–28. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6755-1_6.

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3

Sillman, Christina, and Marilynne Ngo. "Nursing Care for Patients with CHD in the Operating Theater." In Congenital Heart Disease, 205–16. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78423-6_12.

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4

Kappanayil, Mahesh. "3D Prototyping: Technology and Applications for CHD." In CT and MRI in Congenital Heart Diseases, 569–81. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6755-1_24.

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Ahmad, Shoaib, Ahmed Dheyaa Al-Obaidi, Abeer Mundher Ali, and Sara Shihab Ahmad. "Diagnosis of CHD During Perinatal Life." In Clinical and Surgical Aspects of Congenital Heart Diseases, 15–19. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23062-2_3.

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6

Kempny, Aleksander. "Prognostication in PAH–CHD." In Pulmonary Hypertension in Adult Congenital Heart Disease, 315–28. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46028-4_21.

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Jagia, Priya, and Mumun Sinha. "CT and MR Imaging in Post-operative CHD." In CT and MRI in Congenital Heart Diseases, 413–31. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6755-1_18.

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8

Rajeshkannan, Ramiah. "Techniques and Clinical Applications of Phase-Contrast MRI in CHD." In CT and MRI in Congenital Heart Diseases, 471–98. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6755-1_20.

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9

Callus, Edward, Emilia Quadri, Jamie L. Jackson, Elisabeth M. W. J. Utens, and Karolijn Dulfer. "The Role and Guidance of Parents of CHD Patients." In Congenital Heart Disease and Adolescence, 181–90. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31139-5_12.

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Cauldwell, Matt, Mark Cox, Roisin Monteiro, and Mark R. Johnson. "The Management of Labour and the Post-partum Period in CHD." In Pregnancy and Congenital Heart Disease, 83–95. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-38913-4_6.

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Тези доповідей конференцій з теми "Congenital heart diseases (CHD)"

1

Naser, Nabil, and Zumreta Kušljugić. "ADULT CONGENITAL HEART DISEASE – NEW GUIDELINES AND CLINICAL CARE PERSPECTIVE." In International Scientific Symposium “Diagnostics in Cardiology and Grown-Up Congenital Heart Disease (GUCH)”. Academy of Sciences and Arts of Bosnia and Herzegovina, 2021. http://dx.doi.org/10.5644/pi2021.199.04.

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To date, the prevalence of CHD worldwide is ∼9 per 1000 newborns, with substantial geographic variation. The latest knowledge in the world for the last 50 years about their origin, diagnosis and therapy has contributed to their care. Since adult patients with CHD now present increasing numbers at advanced ages, including the elderly, the term grown-up CHD no longer appears appropriate and was therefore replaced with adult CHD (ACHD) according to the ESC guidelines published in 2020 year. Due to medical, surgical, and technological evolutions over the past decades, >90% of individuals who are born with CHD now survive into adulthood. ACHD represent a challenge for clinicians. Despite optimal medical and surgical treatment, many will experience a progressive decline in cardiopulmonary function leading to advanced heart failure. Severe ventricular dysfunction and/or pulmonary hypertension may not be amenable to corrective repair. Their early recognition and follow-up in adolescence will contribute to better care for these patients. Importantly, the care for ACHD patients is a lifelong process and requires advance care planning strategies.
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2

Qian, Y., J. L. Liu, M. Umezu, K. Itatani, and K. Miyaji. "A Study of Surgical Optimization for Congenital Heart Diseases Based on Computational Hemodynamic Analysis." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206443.

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Hypoplastic left heart syndrome (HLHS) is one kind of serious congenital heart diseases (CHD). With a small, underdeveloped left ventricle, a heart suffering from HLHS cannot effectively supply enough blood flow to provide for the needs of the body. In order to improve blood circulation, surgery for HLHS has to be carried out at a very early stage. In general, three-stage palliative surgical management for newborns is now widely accepted [1, 2]; Norwood, Glenn, and Fontan.
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3

Ji, Liqun, Yun Gu, Kun Sun, Jie Yang, and Yu Qiao. "Congenital heart disease (CHD) discrimination in fetal echocardiogram based on 3D feature fusion." In 2016 IEEE International Conference on Image Processing (ICIP). IEEE, 2016. http://dx.doi.org/10.1109/icip.2016.7532994.

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4

El Nihum, Lamees, Ponraj Chinnadurai, C. Huie Lin, and Debjyoti Banerjee. "A Comprehensive Review of 4D Flow MRI and CFD in Cardiovascular and Congenital Heart Disease." In ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65886.

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Abstract A growing population of adults with congenital heart disease (CHD) has spurred increased study in recent decades into the complex anatomical vasculature of congenital heart patients and the resulting hemodynamic changes that progressively affect the heart and great vessels. To this end, assessment of flow dynamics using advanced imaging technology and computational simulations have paved a path toward greater understanding of the patterns and implications of flow alterations in complex and changing vasculature, and offer promise for diagnostic and therapeutic intervention in the future. The focus of this review is to describe past studies of four-dimensional (4D) magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) in the literature as related to pathophysiology of the heart in structural and CHD. This review will highlight the importance of working with both imaging and simulation technology to co-validate experimental (4D MRI) and simulation (CFD) models, allowing for more accurate depiction of flow dynamics within human vasculature and ultimately toward improvement of the tools and methodologies used in analysis, simulation and prediction of cardiovascular hemodynamics toward enhanced diagnostics and therapeutic intervention.
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5

Boethig, D., M. Avsar, U. Bauer, P. Beerbaum, F. Berger, R. Cesnjevar, I. Dähnert, et al. "Lifetime Endocarditis Risk with Congenital Heart Disease and Pulmonary Valve Prosthesis (PVP): Results from the German Registry for Congenital Heart Defects (CHD)." In 51st Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG). Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1742863.

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6

Leci, Enri, Massimiliano Palazzini, Francesca Sciarra, Federica Sgrò, Elisa Conficoni, Elena Beciani, Cristina Bachetti, Alessandra Manes, and Nazzareno Galiè. "Current Era Survival Of Patients With Pulmonary Arterial Hypertension (PAH) Associated With Congenital Heart Disease (CHD)." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6132.

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7

Rugonyi, Sandra, and Kent Thornburg. "Modeling the Effect of Hemodynamics on Cardiac Growth During Embryonic Development." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13171.

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Congenital heart disease (CHD) affects about 1% of newborn babies in the US, and is the leading cause of non-infectious death in children. Abnormal blood flow dynamics during early development can lead to CHD. Although the effect of hemodynamic conditions on cardiac development — even under normal conditions — has been widely accepted, the mechanisms by which blood flow influences cardiac cell responses are only starting to emerge. Mathematical models of cardiac growth could then help elucidate key aspects of cardiac development.
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Barst, RJ, AJ Foreman, DD Ivy, and MD McGoon. "REVEAL Registry: One Year Outcome of Patients with Congenital Heart Disease-Associated Pulmonary Arterial Hypertension (CHD-APAH)." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2656.

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9

Hogg, Claire, Sunayna Best, Amelia Shoemark, Bruna Rubbo, Mitali Patel, Mahmoud Fassad, Julene Carvalho, Priti Kenia, Jane Lucas, and Hannah Mitchison. "Genetic risk factors for laterality defects and congenital heart disease (CHD) in patients with primary ciliary dyskinesia (PCD)." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa1852.

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Tenhoff, Amanda C., Alex J. Deakyne, Tinen L. Iles, Shanti L. Narasimhan, Sameh M. Said, Massimo Griselli, and Paul A. Iaizzo. "Development of an Open-Access Library of Pediatric Congenital Heart Diseases and Treatments: A Tutorial on the Atlas of Human Cardiac Anatomy." In 2020 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/dmd2020-9064.

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Abstract The major aim of this project is to construct a growing database of information regarding specific manifestations of congenital heart diseases (CHDs), subsequent treatments, clinical cases, and patient outcomes. This will include 3D models generated from clinical imaging of individual patient hearts and respective de-identified clinical case information — all of which will be incorporated onto the free-access Atlas of Human Cardiac Anatomy website (http://www.vhlab.umn.edu/atlas/), where anyone can learn more about these diseases and their complexities [1]. Generated models can also be used for 3D printing, such as for pre-surgical planning, as well as for incorporation into virtual reality in order to expand outreach and education efforts [2]. Future work will incorporate computational modeling to enhance insights relative to treatment strategies and surgical planning. By studying a broad range of these unique individual cases, it will be possible for patients, clinicians, and medical device designers alike to better understand the clinical presentations of congenital heart diseases and develop more effective treatment strategies.
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