Готові списки джерел за темами / Chromosone mapping

Добірка наукової літератури з теми "Chromosone mapping"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 29 січня 2023

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Статті в журналах з теми "Chromosone mapping"

1

Hausmann, Michael, C. Paul Popescu, Jeannine Boscher, Dominique Kerboœf, Jürgen Dölle, and Christoph Cremer. "Identification and Cytogenetic Analysis of an Abnormal Pig Chromosome for Flow Cytometry and Sorting." Zeitschrift für Naturforschung C 48, no. 7-8 (August 1, 1993): 645–53. http://dx.doi.org/10.1515/znc-1993-7-819.

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Abstract For cytogenetics of pig (Sus scrofa domestica) and the influence of chromosome aberrations on pig production, high interest exists in flow sorted chromosomes for gene mapping, to estab­lish DNA-libraries, or to produce DNA-probes. Flow karyotyping and sorting as well as slit scan flow analysis of metaphase chromosomes of an abnormal cell type carrying a translocation marker chromosome 6/15 are described. Flow sorting of the largest chromosomes of these cells was performed. After sorting the chromosomes still had a well preserved morphology and were identified microscopically by G-banding. The quality of the band pattern of the sorted chromosomes was compatible to that of isolated chromosomes not subjected to flow cytometry. The sorted fraction showed an enrichment of chromosom e 6/15 and chromosome 1 which have quantitatively about the same integrated fluorescence intensity. Slit scan flow analysis was performed to discriminate these two chromosomes. Metacentric and submetacentric chromosom es were analyzed according to their bimodal slit scan profiles. Profiles of the largest chromosomes were distinguished by their different centromeric indices. Two groups were interpreted as the normal chromosome 1 and the translocation chromosom e 6/15.
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2

Matějíčková, J., M. Štípková, G. Sahana, T. Kott, J. Kyseľová, A. Matějíček, B. Kottová, J. Šefrová, M. Krejčová, and S. Melčová. "QTL mapping for production traits in Czech Fleckvieh cattle." Czech Journal of Animal Science 58, No. 9 (August 29, 2013): 396–403. http://dx.doi.org/10.17221/6939-cjas.

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The objective of this study was to find QTL for milk production traits in Czech Fleckvieh cattle on chromosomes 6, 7, 11, 14, and 23 where QTL were previously identified in other dairy cattle populations. Sixteen grandsire families were genotyped for 38 microsatellite markers on the selected chromosomes. A QTL mapping model based on variance component analysis was implemented via restricted maximum likelihood (REML) to estimate QTL positions and their effects. A significant QTL affecting fat percentage was found at the beginning of chromosome 14 (0 cM), near marker ILSTS039. Suggestive QTL associated with milk production traits appeared on other studied chromosomes (BTA6, BTA7, BTA11, and BTA23). This first QTL search on five chromosomes in Czech Fleckvieh population showed several suggestive QTL that can be promising for further studies and contribute to better understanding of genetics of milk production in the Czech Fleckvieh cattle.  
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3

Sarma, R. N., L. Fish, B. S. Gill, and J. W. Snape. "Physical characterization of the homoeologous Group 5 chromosomes of wheat in terms of rice linkage blocks, and physical mapping of some important genes." Genome 43, no. 1 (February 1, 2000): 191–98. http://dx.doi.org/10.1139/g99-083.

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The wheat homoeologous Group 5 chromosomes were characterized physically in terms of rice linkage blocks using a deletion mapping approach. All three chromosomes, 5A, 5B, and 5D, were shown to have a similar structure, apart from the 4A-5A translocation on the distal end of chromosome arm 5AL. The physical mapping of rice markers on the deletion lines revealed that the whole of rice chromosome 9 is syntenous to a large block, proximal to the centromere, on the long arm. Likewise, a small segment of the distal end of the long arm showed conserved synteny with the distal one-third end of the long arm of rice chromosome 3. In between those conserved regions, there is a region on the long arm of the Group 5 chromosomes which shows broken synteny. The proximal part of the short arms of the Group 5 chromosomes showed conserved synteny with a segment of the short arm of rice chromosome 11 and the distal ends showed conserved synteny with a segment of rice chromosome 12. The physical locations of flowering time genes (Vrn and earliness per se) and the gene for grain hardness (Ha) on the Group 5 chromosomes were determined. These results indicate that comparative mapping using the deletion mapping approach is useful in the study of genome relationships, the physical location of genes, and can determine the appropriate gene cloning strategy. Key words: wheat, rice, comparative mapping, deletion lines.
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4

Kubaláková, M., M. Valárik, J. Bartoš, J. Vrána, J. Cíhalíková, M. Molnár-Láng, and J. Dolezel. "Analysis and sorting of rye (Secale cereale L.) chromosomes using flow cytometry." Genome 46, no. 5 (October 1, 2003): 893–905. http://dx.doi.org/10.1139/g03-054.

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Procedures for chromosome analysis and sorting using flow cytometry (flow cytogenetics) were developed for rye (Secale cereale L.). Suspensions of intact chromosomes were prepared by mechanical homogenization of synchronized root tips after mild fixation with formaldehyde. Histograms of relative fluorescence intensity obtained after the analysis of DAPI-stained chromosomes (flow karyotypes) were characterized and the chromosome content of the DNA peaks was determined. Chromosome 1R could be discriminated on a flow karyotype of S. cereale 'Imperial'. The remaining rye chromosomes (2R–7R) could be discriminated and sorted from individual wheat–rye addition lines. The analysis of lines with reconstructed karyotypes demonstrated a possibility of sorting translocation chromosomes. Supernumerary B chromosomes could be sorted from an experimental rye population and from S. cereale 'Adams'. Flow-sorted chromosomes were identified by fluorescence in situ hybridization (FISH) with probes for various DNA repeats. Large numbers of chromosomes of a single type sorted onto microscopic slides facilitated detection of rarely occurring chromosome variants by FISH with specific probes. PCR with chromosome-specific primers confirmed the identity of sorted fractions and indicated suitability of sorted chromosomes for physical mapping. The possibility to sort large numbers of chromosomes opens a way for the construction of large-insert chromosome-specific DNA libraries in rye.Key words: chromosome isolation, chromosome sorting, fluorescence in situ hybridization, repetitive DNA sequences, wheat-rye addition lines, B chromosomes, physical mapping.
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5

Allen, Sally Lyman, Dawn Zeilinger, and Eduardo Orias. "Mapping Three Classical Isozyme Loci in Tetrahymena: Meiotic Linkage of EstA to the ChxA Linkage Group." Genetics 144, no. 4 (December 1, 1996): 1489–96. http://dx.doi.org/10.1093/genetics/144.4.1489.

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We demonstrate a reliable method for mapping conventional loci and obtaining meiotic linkage data for the ciliated protozoan Tetrahymena thermophila. By coupling nullisomic deletion mapping with meiotic linkage mapping, loci known to be located on a particular chromosome or chromosome arm can be tested for recombination. This approach has been used to map three isozyme loci, EstA (Esterase A), EstB (Esterase B), and AcpA (Acid Phosphatase A), with respect to the ChxA locus (cycloheximide resistance) and 11 RAPDs (randomly amplified polymorphic DNAs). To assign isozyme loci to chromosomes, clones of inbred strains C3 or C2 were crossed to inbred strain B nullisomics. EstA, EstB and AcpA were mapped to chromosomes 1R, 3L and 3R, respectively. To test EstA and AcpA for linkage to known RAPD loci on their respective chromosomes, a panel of Round II (genomic exclusion) segregants from a B/C3 heterozygote was used. Using the MAPMAKER program, EstA was assigned to the ChxA linkage group on chromosome IR, and a detailed map was constructed that includes 10 RAPDs. AcpA (on 3R), while unlinked to all the RAPDs assigned to chromosome 3 by nullisomic mapping, does show linkage to a RAPD not yet assignable to chromosomes by nullisomic mapping.
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6

Bedo, D. G. "Polytene chromosome mapping in Ceratitis capitata (Diptera: Tephritidae)." Genome 29, no. 4 (August 1, 1987): 598–611. http://dx.doi.org/10.1139/g87-101.

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Polytene chromosome reference maps of the five autosomes of Ceratitis capitata from male pupal orbital bristle trichogen cells are presented and a correlation is established between two of them and the two largest of the five autosomes in the haploid mitotic complement. Characteristic features of each chromosome are described identifying areas that are difficult to analyze and noting the existence of common alternative band expression. A quantitative analysis of the mitotic karyotype of C. capitata indicates that the two smallest autosome pairs cannot be reliably distinguished. This may present problems with future attempts to establish homologies between the remaining mitotic and polytene chromosomes. A comparison of polytene chromosome banding patterns from salivary gland and trichogen cells failed to find any homologous regions, or even to identify homologous chromosomes. The banding differences are not explained by variation in puffing patterns, heterochromatin expression, or polyteny levels, but appear to reflect fundamental differences in banding patterns of the chromosomes in each tissue. Key words: Ceratitis capitata, polytene chromosome map, mitotic chromosome measurements.
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7

Ziolkowski, Piotr A., and Jan Sadowski. "FISH-mapping of rDNAs and Arabidopsis BACs on pachytene complements of selected Brassicas." Genome 45, no. 1 (February 1, 2002): 189–97. http://dx.doi.org/10.1139/g01-101.

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To improve resolution of physical mapping on Brassica chromosomes, we have chosen the pachytene stage of meiosis where incompletely condensed bivalents are much longer than their counterparts at mitotic metaphase. Mapping with 5S and 45S rDNA sequences demonstrated the advantage of pachytene chromosomes in efficient physical mapping and confirmed the presence of a novel 5S rDNA locus in Brassica oleracea, initially identified by genetic mapping using restriction fragment length polymorphism (RFLP). Fluorescence in situ hybridization (FISH) analysis visualized the presence of the third 5S rDNA locus on the long arm of chromosome C2 and confirmed the earlier reports of two 45S rDNA loci in the B. oleracea genome. FISH mapping of low-copy sequences from the Arabidopsis thaliana bacterial artificial chromosome (BAC) clones on the B. oleracea chromosomes confirmed the expectation of efficient and precise physical mapping of meiotic bivalents based on data available from A. thaliana and indicated conserved organization of these two BAC sequences on two B. oleracea chromosomes. Based on the heterologous in situ hybridization with BACs and their mapping applied to long pachytene bivalents, a new approach in comparative analysis of Brassica and A. thaliana genomes is discussed.Key words: Brassicaceae, pachytene chromosomes, FISH, rDNA, BACs.
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8

Cheng, Zhukuan, Gernot G. Presting, C. Robin Buell, Rod A. Wing, and Jiming Jiang. "High-Resolution Pachytene Chromosome Mapping of Bacterial Artificial Chromosomes Anchored by Genetic Markers Reveals the Centromere Location and the Distribution of Genetic Recombination Along Chromosome 10 of Rice." Genetics 157, no. 4 (April 1, 2001): 1749–57. http://dx.doi.org/10.1093/genetics/157.4.1749.

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AbstractLarge-scale physical mapping has been a major challenge for plant geneticists due to the lack of techniques that are widely affordable and can be applied to different species. Here we present a physical map of rice chromosome 10 developed by fluorescence in situ hybridization (FISH) mapping of bacterial artificial chromosome (BAC) clones on meiotic pachytene chromosomes. This physical map is fully integrated with a genetic linkage map of rice chromosome 10 because each BAC clone is anchored by a genetically mapped restriction fragment length polymorphism marker. The pachytene chromosome-based FISH mapping shows a superior resolving power compared to the somatic metaphase chromosome-based methods. The telomere-centromere orientation of DNA clones separated by 40 kb can be resolved on early pachytene chromosomes. Genetic recombination is generally evenly distributed along rice chromosome 10. However, the highly heterochromatic short arm shows a lower recombination frequency than the largely euchromatic long arm. Suppression of recombination was found in the centromeric region, but the affected region is far smaller than those reported in wheat and barley. Our FISH mapping effort also revealed the precise genetic position of the centromere on chromosome 10.
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9

Kang, Lin, Phillip George, Donald K. Price, Igor Sharakhov, and Pawel Michalak. "Mapping Genomic Scaffolds to Chromosomes Using Laser Capture Microdissection in Application to Hawaiian Picture-Winged Drosophila." Cytogenetic and Genome Research 152, no. 4 (2017): 204–12. http://dx.doi.org/10.1159/000481790.

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Next-generation sequencing technologies have led to a decreased cost and an increased throughput in genome sequencing. Yet, many genome assemblies based on short sequencing reads have been assembled only to the scaffold level due to the lack of sufficient chromosome mapping information. Traditional ways of mapping scaffolds to chromosomes require a large amount of laboratory work and time to generate genetic and/or physical maps. To address this problem, we conducted a rapid technique which uses laser capture microdissection and enables mapping scaffolds of de novo genome assemblies directly to chromosomes in Hawaiian picture-winged Drosophila. We isolated and sequenced intact chromosome arms from larvae of D. differens. By mapping the reads of each chromosome to the recently assembled scaffolds from 3 Hawaiian picture-winged Drosophila species, at least 67% of the scaffolds were successfully assigned to chromosome arms. Even though the scaffolds are not ordered within a chromosome, the fast-generated chromosome information allows for chromosome-related analyses after genome assembling. We utilize this new information to test the faster-X evolution effect for the first time in these Hawaiian picture-winged Drosophila species.
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10

Lukaszewski, Adam J. "Genetic mapping in the 1R.1D wheat–rye translocated chromosomes." Genome 37, no. 6 (December 1, 1994): 945–49. http://dx.doi.org/10.1139/g94-134.

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Translocation chromosomes 1R.1D5+10−1 and 1R.1D5+10−2 were produced to improve bread-making quality in triticale and to manipulate the dosage of the Glu-D1 gene in wheat. They involve transfers of segments of the long arm of chromosome 1D of bread wheat to the long arm of rye chromosome 1R. The translocated long arms of the chromosomes were mapped genetically in wheat and triticale using polymorphism for C-banding patterns, allelic variation of the Glu-D1 gene, and a telocentric chromosome 1RL. The total frequency and the general distribution of recombination in the translocated arms was similar to that in normal long arms of group-1 chromosomes in wheat, rye, and triticale, except that the distal rye segments of the translocations showed a 15- to 20-fold increase in recombination frequency compared with normal 1R. Despite major differences in the physical structure of the translocated arms, both appeared very similar genetically, suggesting that genetic mapping is a poor indicator of the physical structure of translocations. Genetic length of the 1DL segment in chromosome 1R.1D5+10−1 was 31 cM, making the chromosome unsuitable for Glu-D1 dosage manipulation in wheat. The potential of chromosome 1R.1D5+10−2 for wheat breeding needs further testing. However, both chromosomes behave normally in hexaploid triticale.Key words: translocation, linkage, bread-making quality, wheat, triticale.
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Дисертації з теми "Chromosone mapping"

1

Morroll, Shaun Michael. "Mapping of yeast artificial chromosomes from Arabidopsis chromosome 5." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308922.

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2

Åkesson, Eva. "Genetic mapping and association analysis in multiple sclerosis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-174-1/.

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3

Stephens, Sarah H. "Fine mapping of the chromosome 15q13-14 schizophrenia linkage region /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Human Medical Genetics) -- University of Colorado Denver, 2008.
Typescript. Includes bibliographical references (leaves 112-128). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
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4

Brinkman-Mills, Polly. "Transcriptional mapping in human chromosome 22q11.2." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/MQ47011.pdf.

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5

Apostolou, Sinoula. "Physical mapping of human chromosome 16." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09pha645.pdf.

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6

He, Bing. "Susceptibility gene mapping in multiple sclerosis /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980608he.

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7

Söderhäll, Cilla. "Gene mapping of atopic dermatitis /." Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-088-1/.

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8

Holm, Sofia. "Molecular genetic studies of psoriasis susceptibility in 6p21.3 /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-225-X.

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9

Dutton, Elizabeth R. "Mapping studies on mouse distal Chromosome 2." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299401.

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10

Creavin, Treasa Agnes Della Geraldine. "Transcriptional mapping of human chromosome 16p12.3-p12.2." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321891.

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Книги з теми "Chromosone mapping"

1

James, Louise Anne. Physical mapping on human chromosome 3 using yeast artificial chromosomes. Manchester: University of Manchester, 1994.

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2

F, Verrity Jennifer, and Abbington Lilian E, eds. Chromosome mapping research developments. New York: Nova Science, 2008.

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3

Chromosome maps of Drosophila. Boca Raton, Fla: CRC Press, 1988.

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4

The genome. New York, N.Y: VCH Publishers, 1990.

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5

Animal genomes under the focus of cytogenetics. New York: Nova Science Publishers, 2011.

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6

E, Davies K., ed. Genome analysis: A practical approach. Oxford: IRL Press, 1988.

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7

United States. Department of Energy. Health and Environmental Research Advisory Committee. Subcommittee on Human Genome. Report on the human genome initiative for the Office of Health and Environmental Research. Washington, DC]: [D.O.E.], 1987.

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8

United States. Congress. Senate. Committee on Energy and Natural Resources. Subcommittee on Energy Research and Development. The human genome project: Hearing before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources, United States Senate, One Hundred First Congress, second session on the human genome project, July 11, 1990. Washington: U.S. G.P.O., 1990.

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9

Scherer, Stephen W. Physical mapping of human chromosome 7 with yeast artificial chromosome (YAC) vectors. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1991.

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10

Poptsova, Maria S. Genome analysis: Current procedures and applications. Norfolk, UK: Caister Academic Press, 2014.

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Частини книг з теми "Chromosone mapping"

1

Gill, Bikram S. "A Century of Cytogenetic and Genome Analysis: Impact on Wheat Crop Improvement." In Wheat Improvement, 277–97. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-90673-3_16.

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AbstractBeginning in the first decade of 1900, pioneering research in disease resistance and seed color inheritance established the scientific basis of Mendelian inheritance in wheat breeding. A series of breakthroughs in chromosome and genome analysis beginning in the 1920s and continuing into the twenty-first century have impacted wheat improvement. The application of meiotic chromosome pairing in the 1920s and plasmon analysis in the 1950s elucidated phylogeny of the Triticum-Aegilops complex of species and defined the wheat gene pools. The aneuploid stocks in the 1950s opened floodgates for chromosome and arm mapping of first phenotypic and later protein and DNA probes. The aneuploid stocks, coupled with advances in chromosome banding and in situ hybridization in the 1970s, allowed precise chromosome engineering of traits in wide hybrids. The deletion stocks in the 1990s were pivotal in mapping expressed genes to specific chromosome bins revealing structural and functional differentiation of chromosomes along their length and facilitating map-based cloning of genes. Advances in whole-genome sequencing, chromosome genomics, RH mapping and functional tools led to the assembly of reference sequence of Chinese Spring and multiple wheat genomes. Chromosome and genomic analysis must be integrated into wheat breeding and wide-hybridizaton pipeline for sustainable crop improvement.
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2

Clark, M. S., and W. J. Wall. "Chromosome mapping." In Chromosomes, 176–205. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0073-8_7.

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3

Gooch, Jan W. "Chromosome Mapping." In Encyclopedic Dictionary of Polymers, 882. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13392.

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4

Miller, Orlando J., and Eeva Therman. "Mapping Human Chromosomes." In Human Chromosomes, 431–46. New York, NY: Springer New York, 2001. http://dx.doi.org/10.1007/978-1-4613-0139-4_29.

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5

Appels, Rudi, Rosalind Morris, Bikram S. Gill, and Cedric E. May. "Genetic and Molecular Mapping of Chromosomes." In Chromosome Biology, 318–37. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5409-7_21.

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6

Therman, Eeva. "Mapping of Human Chromosomes." In Human Chromosomes, 282–93. New York, NY: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-0269-8_28.

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7

Therman, Eeva, and Millard Susman. "Mapping of Human Chromosomes." In Human Chromosomes, 331–47. New York, NY: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4684-0529-3_31.

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8

Créau-Goldberg, N., C. Cochet, C. Turleau, and J. de Grouchy. "Comparative gene mapping and primate evolution." In Chromosomes Today, 103–14. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-010-9166-4_10.

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9

Malembic-Maher, Sylvie, and Patricia Carle. "Mapping the Phytoplasma Chromosome." In Methods in Molecular Biology, 405–16. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-089-2_34.

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10

Keshava, Rohini. "Chromosome Mapping in Eukaryotes." In Genetics Fundamentals Notes, 165–237. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7041-1_4.

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Тези доповідей конференцій з теми "Chromosone mapping"

1

Jain, Sakait, and Hae Chang Gea. "Two-Dimensional Packing Problems Using Genetic Algorithms." In ASME 1996 Design Engineering Technical Conferences and Computers in Engineering Conference. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/96-detc/dac-1466.

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Abstract This paper presents a technique for applying genetic algorithms for the two dimensional packing problem. The approach is applicable to not only convex shaped objects, but, can also accommodate any type of concave and complex shaped objects including objects with holes. In this approach, a new concept of a two dimensional genetic chromosome is introduced. The total layout space is divided into a finite number of cells for mapping it into this 2-D genetic algorithm chromosome. The mutation and crossover operators have been modified and are applied in conjunction with connectivity analysis for the objects to reduce the creation of faulty generations. A new feature has been added to the genetic algorithm(GA) in the form of a new operator called compaction. Several examples of GA based layout are presented.
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2

Liu, Yu, Kaitai Zhang, Xinyu Zhang, Yanning Gao, and Ying Hu. "ArraySVG: Chromosome mapping and network visualization of multi-platform data." In 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2010. http://dx.doi.org/10.1109/bmei.2010.5639343.

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3

Salleh, Syafinaz, and Ahmad Abas Kutty. "Chironomus group classification according to the mapping of polytene chromosomes." In THE 2013 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2013 Postgraduate Colloquium. AIP Publishing LLC, 2013. http://dx.doi.org/10.1063/1.4858722.

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4

Wan, YI, DP Strachan, IP Hall, and I. Sayers. "Fine Mapping of Atopy Loci on Chromosomes 3 and 17." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5410.

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5

Sharakhova, Maria V. "Advanced cytogenetic physical mapping for the development of chromosome-based genome assemblies." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.109079.

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6

Jain, Sakait, and Hae Chang Gea. "PCB Layout Design Using a Genetic Algorithm." In ASME 1995 Design Engineering Technical Conferences collocated with the ASME 1995 15th International Computers in Engineering Conference and the ASME 1995 9th Annual Engineering Database Symposium. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/detc1995-0070.

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Abstract This paper presents an approach to find the optimal design layout of chips on a circuit board in a manner that minimizes the area covered on the board and the connections between the various chips. In addition, there are no major heat sources next to each other and certain physical constraints are satisfied while finding a layout design. In this approach, the whole circuit board area is divided into a finite number of cells for mapping it into a genetic algorithm chromosome. The mutation and crossover operators have been modified and are applied in conjunction with connectivity analysis for the chips to reduce the creation of a lot of faulty generations. Examples of GA based chip layout are presented to show how each of the objectives are attained separately followed by examples to arrive at layouts using multiple objectives.
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7

Collins, Justin, and David Joslin. "Improving genetic algorithm performance with intelligent mappings from chromosomes to solutions." In the 8th annual conference. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1143997.1144218.

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8

Chapman, Colin D., Kazuhiro Saitou, and Mark J. Jakiela. "Genetic Algorithms As an Approach to Configuration and Topology Design." In ASME 1993 Design Technical Conferences. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/detc1993-0338.

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Abstract The Genetic Algorithm, a search and optimization technique based on the theory of natural selection, is applied to problems of structural topology optimization. Given a structure’s boundary conditions and maximum allowable design domain, a discretized design representation is created. Populations of genetic algorithm “chromosomes” are then mapped into the design representation, creating potentially optimal structure topologies. Utilizing genetics-based operators such as crossover and mutation, generations of increasingly-desirable structure topologies are created. In this paper, the use of the genetic algorithm (GA) in structural topology optimization is presented. An overview of the genetic algorithm will describe the genetics-based representations and operators used in a typical genetic algorithm search. After defining topology optimization and its relation to the broader area of structural optimization, a review of previous research in GA-based and non-GA-based structural optimization is provided. The design representations, and methods for mapping genetic algorithm “chromosomes” into structure topology representations, are then detailed. Several examples of genetic algorithm-based structural topology optimization are provided: we address the optimization of beam cross-section topologies and cantilevered plate topologies, and we also investigate efficient techniques for using finite element analysis in a genetic algorithm-based search. Finally, a description of potential future work in genetic algorithm-based structural topology optimization is offered.
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9

Ploos van Amstel, J. K., A. L. van der Zanden, P. H. Reitsma, and R. M. Bertina. "RESTRICTION ANALYSIS AND SOUTHERN BLOTTING OF TOTAL HUMAN DNA REVEALS THE EXISTENCE OF MORE THAN ONE GENE HOMOLOGOUS WITH PROTEIN S cDNA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644639.

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A deficiency in protein S, the cofactor of activated protein C, is associated with an increased risk for the development of venous thrombosis. It is inherited as an autosomal dominant disorder. To improve the detection of heterozygotes in affected families, we have started to search for restriction fragment length polymorphism (RFLP) in the protein S gene. This study revealed the existence of two genes containing sequences homologous to protein S cDNA.Three non-overlapping fragments of clone pSUL5, which codes for the carboxy-terminal part of protein S and contains the complete 3' untranslated region, were isolated and used as probes in search for RFLP of the protein S gene.Surprisingly the non-overlapping probes shared more than one hybridizing band. The hybridization took place under stringent assay conditions.This observation is contradictory to the intron-exon organization of a gene and suggests the existence of two genes, containing sequences homologous with pSUL5. Both genes could be assigned to chromosome 3 by mapping through somatic cell hybrids. Whether two functional protein S genes are present in the human genome remains to be established.
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Feusier, Julie Ellen, Michael J. Madsen, Karl Voelkerding, Martha Glenn, and Nicola Camp. "Abstract 2119: Gene mapping in high-risk chronic lymphocytic leukemia pedigree identifies risk locus at chromosome 2q22.1." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2119.

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Звіти організацій з теми "Chromosone mapping"

1

Antonarakis, S. E. Human Chromosome 21: Mapping of the chromosomes and cloning of cDNAs. Office of Scientific and Technical Information (OSTI), September 1991. http://dx.doi.org/10.2172/6397375.

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2

Antonarakis, S. E. Human chromosome 21: Linkage mapping and cloning in yeast artificial chromosomes. Office of Scientific and Technical Information (OSTI), January 1991. http://dx.doi.org/10.2172/6278130.

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3

Feldman, Moshe, Eitan Millet, Calvin O. Qualset, and Patrick E. McGuire. Mapping and Tagging by DNA Markers of Wild Emmer Alleles that Improve Quantitative Traits in Common Wheat. United States Department of Agriculture, February 2001. http://dx.doi.org/10.32747/2001.7573081.bard.

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The general goal was to identify, map, and tag, with DNA markers, segments of chromosomes of a wild species (wild emmer wheat, the progenitor of cultivated wheat) determining the number, chromosomal locations, interactions, and effects of genes that control quantitative traits when transferred to a cultivated plant (bread wheat). Slight modifications were introduced and not all objectives could be completed within the human and financial resources available, as noted with the specific objectives listed below: 1. To identify the genetic contribution of each of the available wild emmer chromosome-arm substitution lines (CASLs) in the bread wheat cultivar Bethlehem for quantitative traits, including grain yield and its components and grain protein concentration and yield, and the effect of major loci affecting the quality of end-use products. [The quality of end-use products was not analyzed.] 2. To determine the extent and nature of genetic interactions (epistatic effects) between and within homoeologous groups 1 and 7 for the chromosome arms carrying "wild" and "cultivated" alleles as expressed in grain and protein yields and other quantitative traits. [Two experiments were successful, grain protein concentration could not be measured; data are partially analyzed.] 3. To derive recombinant substitution lines (RSLs) for the chromosome arms of homoeologous groups 1 and 7 that were found previously to promote grain and protein yields of cultivated wheat. [The selection of groups 1 and 7 tons based on grain yield in pot experiments. After project began, it was decided also to derive RSLs for the available arms of homoeologous group 4 (4AS and 4BL), based on the apparent importance of chromosome group 4, based on early field trials of the CASLs.] 4. To characterize the RSLs for quantitative traits as in objective 1 and map and tag chromosome segments producing significant effects (quantitative trait loci, QTLs by RFLP markers. [Producing a large population of RSLs for each chromosome arm and mapping them proved more difficult than anticipated, low numbers of RSLs were obtained for two of the chromosome arms.] 5. To construct recombination genetic maps of chromosomes of homoeologous groups 1 and 7 and to compare them to existing maps of wheat and other cereals [Genetic maps are not complete for homoeologous groups 4 and 7.] The rationale for this project is that wild species have characteristics that would be valuable if transferred to a crop plant. We demonstrated the sequence of chromosome manipulations and genetic tests needed to confirm this potential value and enhance transfer. This research has shown that a wild tetraploid species harbors genetic variability for quantitative traits that is interactive and not simply additive when introduced into a common genetic background. Chromosomal segments from several chromosome arms improve yield and protein in wheat but their effect is presumably enhanced when combination of genes from several segments are integrated into a single genotype in order to achieve the benefits of genes from the wild species. The interaction between these genes and those in the recipient species must be accounted for. The results of this study provide a scientific basis for some of the disappointing results that have historically obtained when using wild species as donors for crop improvement and provide a strategy for further successes.
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4

Sutherland, G. R. Physical mapping of human chromosome 16. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/7236268.

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5

Connolly, Sarah. Mapping genes to human chromosome 19. Office of Scientific and Technical Information (OSTI), May 1996. http://dx.doi.org/10.2172/576741.

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6

Marrone, B. L., L. L. Deaven, D. J. Chen, Min S. Park, M. A. MacInnes, G. C. Salzman, and T. M. Yoshida. Directly labeled fluorescent DNA probes for chromosome mapping. Office of Scientific and Technical Information (OSTI), December 1995. http://dx.doi.org/10.2172/205135.

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7

Barker, D. F. Molecular mapping of chromosomes 17 and X. Office of Scientific and Technical Information (OSTI), January 1989. http://dx.doi.org/10.2172/6697096.

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8

Barker, D. F. Molecular mapping of chromosomes 17 and X. Office of Scientific and Technical Information (OSTI), January 1991. http://dx.doi.org/10.2172/6659529.

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9

Caskey, C., D. Nelson, and D. Ledbetter. Mapping and ordered cloning of the human X chromosome. Office of Scientific and Technical Information (OSTI), October 1989. http://dx.doi.org/10.2172/5518435.

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10

Caskey, C. T., and D. L. Nelson. Mapping and ordered cloning of the human X chromosome. Office of Scientific and Technical Information (OSTI), December 1992. http://dx.doi.org/10.2172/6387495.

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