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Статті в журналах з теми "Chromatographie phase liquide spectrométrie de masse":
Soichot, M., D. Bouvry, A. Gaudin, C. Oppon, O. Laprévote, H. Gourlain, and E. Bourgogne. "Criblage toxicologique : comparaison de résultats obtenus par chromatographie en phase gazeuse–spectrométrie de masse (CG–SM)/par chromatographie liquide–spectrométrie UV à barrette de diodes–spectrométrie de masse (CL–UV/BD–SM) vs. chromatographie liquide–trappe ionique (CL–SMn)." Toxicologie Analytique et Clinique 28, no. 2 (June 2016): S35. http://dx.doi.org/10.1016/j.toxac.2016.03.059.
Kariyawasam, Dulanjalee, Thao Nguyen-Khoa, Laura Gonzalez Briceño, and Michel Polak. "Le dépistage néonatal de l’hyperplasie congénitale des glandes surrénales." médecine/sciences 37, no. 5 (May 2021): 500–506. http://dx.doi.org/10.1051/medsci/2021060.
Labat, Laurence, Antonio Goncalves, Cédric Cleophax, Bruno Megarbane, and Xavier Decleves. "Dosage du baclofène dans le plasma en chromatographie phase liquide couplée à de la spectrométrie de masse en tandem : à propos d’un cas de surdosage." Toxicologie Analytique et Clinique 28, no. 3 (September 2016): 211–17. http://dx.doi.org/10.1016/j.toxac.2016.04.001.
Bazus, Léa, Nicolas Cimetiere, Laurent Legentil, Guy Randon, and Dominique Wolbert. "Recherche de dérivés conjugués de médicaments dans l’eau de surface et en cours de potabilisation." Revue des sciences de l’eau 28, no. 1 (April 21, 2015): 19–25. http://dx.doi.org/10.7202/1030003ar.
Agbekodo, K. M., J. P. Croué, S. Dard, and B. Legube. "Analyse par HPLC et CG/SM des constituants du carbone organique dissous (COD), du COD biodégradable (CODB) et des composés organohalogénés (TOX) d'un perméat de nanofiltration." Revue des sciences de l'eau 9, no. 4 (April 12, 2005): 535–55. http://dx.doi.org/10.7202/705266ar.
Boumrah, Y., L. Humbert, M. Phanithavong, C. Richeval, K. Khimeche, A. Dahmani, and D. Allorge. "Métabolisme des NBOMes : production in vitro et identification par chromatographie liquide couplée à la spectrométrie de masse à haute résolution de leurs métabolites de phases 1 et 2." Toxicologie Analytique et Clinique 27, no. 2 (June 2015): S24—S25. http://dx.doi.org/10.1016/j.toxac.2015.03.026.
Pivert, G. "Spectrométrie de masse associée à la chromatographie liquide : technologie, applications." IRBM News 29, no. 3-4 (October 2008): 32–35. http://dx.doi.org/10.1016/s1959-7568(08)75560-3.
Cheze, Marjorie, François Vayssette, and Gilbert Pépin. "Dosage du LSD dans les phanères par chromatographie liquide couplée à la spectrométrie de masse ou par chromatographie gazeuse couplée à la spectrométrie de masse tandem." Annales de Toxicologie Analytique 13, no. 2 (2001): 63–68. http://dx.doi.org/10.1051/ata/2001003.
Fraissinet, F., P. Seraissol, S. Nassar, M. Lavit, and P. Gandia. "Dosage de la metformine par chromatographie liquide d’interaction hydrophile couplée à la spectrométrie de masse." Toxicologie Analytique et Clinique 28, no. 2 (June 2016): S39. http://dx.doi.org/10.1016/j.toxac.2016.03.066.
Caqueret, A., and P. O. Hétu. "Dosage de l'éthyl glucuronide urinaire par chromatographie liquide couplée à la spectrométrie de masse en tandem." Clinical Biochemistry 45, no. 13-14 (September 2012): 1103. http://dx.doi.org/10.1016/j.clinbiochem.2012.07.018.
Дисертації з теми "Chromatographie phase liquide spectrométrie de masse":
Himbert, Franck. "Purification d'un mélange multicomposés en chromatographie liquide préparative : colonne, injection & couplage à la spectrométrie de masse." Orléans, 2003. http://www.theses.fr/2003ORLE2042.
Wolters, Cédric. "Caractérisation moléculaire d’échantillons organiques complexes par spectrométrie de masse et chromatographie en phase liquide." Thesis, Université Grenoble Alpes, 2021. http://www.theses.fr/2021GRALU009.
How to analyse a complex organic sample? This general question seems simple at first glance but requires a closer look at the notion of complexity to be able to understand and justify the means used to characterise it. In planetology, and more widely in astrophysics, all the observations and observables indicate that the matter that makes up extraterrestrial objects is composed of a mixture of various molecules, and this mixture is more or less diverse and dense depending on the object. Observations and models are routinely done to try to understand these objects and to constrain their evolutionary processes, or to try to investigate their origin.Characterising the molecular complexity of such objects requires state-of-the-art instruments, which are difficult to adapt to space industry constraints in order to be placed on a probe, and this requires that the object under study can be sampled. However, most objects of interest cannot be reached in a reasonable time. Therefore, another way to study these objects is needed: laboratory astrophysics. Many experiments attempt to simulate the objects and environments in which they evolve and analyse the evolution of matter subjected to these constraints. Part of the challenges of these experiments lies in the chemical characterisation of the samples, and more particularly in their molecular characterisation.As part of this thesis, we proposed to use high-resolution mass spectrometry (HRMS) and high-performance liquid chromatography (HPLC) to characterise complex organic samples. To do so, the entire analytical chain was studied, from the data acquisition to its use. Thus, we proposed an optimisation of the data acquisition in Orbitrap, as well as the systematic processing of the data resulting from the analysis done by ESI-HRMS as well as for the analysis done by LDI-ICR. Chromatography coupled with mass spectrometry is a powerful tool for accessing the molecular structure of samples and requires developing methods that are suited to the samples analysed. Therefore we offered two HPLC methods for sample analysis, which have been developed and validated for the analysis of complex samples. However, no currently available commercial software allowed for the unsupervised analysis of such samples. Software to allow the processing of this data has now been developed and allows the molecular diversity of samples to be revealed without supervision. The identification of the detected molecules is not an easy process since it then requires having all the possible isomers for each molecule detected as standards for reference. To reduce the number of possibilities, a tool for predicting retention times was proposed. This was based on knowledge of the physico-chemical properties of known compounds to predict their theoretical retention time on the methods used.Lastly, this work presents the application of all the developments carried out during these three years on a set of samples of synthetic atmospheric aerosol analogues modelling exoplanets of the super-Earth and mini-Neptunes type. From the analysis of their soluble matter to the comparison between soluble, insoluble, and total phase, analysis by mass spectrometry indicates a great diversity and important differences between samples. This indicates processes of formation and evolution related to the composition of the reactive mixture. Finally, chromatographic analysis of one of these samples indicates multiple isomers, some of which may be labelled as biological molecules, potentially involved in the process of the origin of life
Dufour, Alizée. "Caractérisation des tensioactifs polydisperses industriels par spectrométrie de masse et chromatographie en phase liquide." Thesis, Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLS019.
IIn the petroleum industry, surfactant formulation is becoming more and more complex, especially in thecase of Enhanced Oil Recovery. Analytical challenges therefore appear when monitoring these surfactants.After a detailed characterisation using high resolution mass spectrometry (HRMS), a preliminary studyallowed a better understanding of the chomatographic behaviours of surfactants on different stationnaryphases. A screening of nine different columns showed that LC-1D separation did not result in a completeseparation due to the range of polarities and the polydispersity of the compounds. However, thedevelopment of a multi-dimensional approach solved the co-eluting observed in LC-1D. Following this proofof concept, the determination of the response factor, using charged aerosol detection, underlined the lackof a uniform response within a distribution. This has a strong impact on the mass balance. Finally, theinfluence of the presence of oil was demonstrated by studying a mixture of anionic and nonionic surfactantsin oil matrix. The separation was maintained but the presence of organic solvent and crude oil has a crucialimpact on the signal
Roy, Sylvie. "Couplage de la chromatographie liquide haute performance et de la spectrométrie de masse." Paris 5, 1989. http://www.theses.fr/1989PA05P035.
Jeudy, Jérémy. "Quantification de biomarqueurs protéiques dans des matrices biologiques complexes par spectrométrie de masse : développements et applications." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10242/document.
Over the past decade, interest in the use of biomarkers in clinical studies has greatly increased. Quantification of a candidate protein biomarker in complex samples (eg. plasma) requires targeted and multiplexed assays. Immunoassays are the gold standard for their quantification. However, with the need for targeted and multiplexed methods, recent developments in mass spectrometry (MS) make a viable alternative to ELISA. The present work has addressed the problems encountered in this type of proteomic studies, and solutions that can be explored to improve the workflow of candidate biomarker’s evaluation. Methionine peptides are generally avoided due to their susceptibility to oxidation. However, it seemed interesting to study how their endogenous modifications could affect biological processes. In a first time, apolipoproteins were dismissed as a potential biomarker of Alzheimer’s disease due to oxidation impact. In the same time, problems associated with biological sample collection and storage were highlighted. DBS (Dried Blood Spot) and Vivid device evaluation from a panel of 32 blood proteins has provided a first possible solution to overcome these troubles. Thereafter, a new peptide quantification method called MRM3 was used to overcome biological matrix complexity. Reliable level determinations of 2 plasma proteins (C-Reactive protein and TIMP-1) and 2 urinary proteins (aquaporin-2 and podocin) were obtained. To improve sensitivity and reduce analysis solvent costs, performances of a micro chromatography platform were compared to a narrow-bore platform. This study highlighted the significant impact of the matrix effect on the analytical process, requiring new strategie development. Finally, to reduce sample complexity, evaluation of wide pore solid-phase extraction cartridges has been achieved. A protocol was successfully developed to analyze enzymes contained in commercial laundry samples. Finally to optimize biological sample preparation time, heated-assisted digestion and online desalting step were successfully associated. Only few hours were then required for quantitative analysis
Rougemont, Blandine. "Quantification de protéines dans des matrices complexes par spectrométrie de masse : nouveaux outils et apllications." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1084/document.
Tandem mass spectrometry is now a technique of choice for human or micro-organisms proteome analysis. Typically, proteins are first digested into surrogates’ peptides, separated by liquid chromatography before being analyzed by MS/MS. The ultimate goal is the identification and the quantification of these peptides, belonging to proteins and highlighting a phenotype or a cellular mechanism in a complex organism. Both targeted and untargeted approaches are used and are complementary in proteomic analysis. The work presented here is focused on the development of targeted methods, and more particularly in the SRM mode, through two applications involving micro-organisms. So, the first study concerned to absolute quantification of viral proteins of the chimeric yellow-dengue fever, vaccine candidate against dengue. By using the AQUA quantification strategy, we were able to develop, to validate and to transfer the method for the four chimeric virus serotypes. Then, problems met during development process, lead us to suggest check points to verify when using AQUA strategy. In a second part, we attempted to develop a quantitative label free analysis of 445 proteins to study the infection of the phytopathogen Dickeya dadantii, on a model plant. To ensure a simple and fast transfer of this multiplex, we purpose a new acquisition tool, independent from retention time. This tool was developed in a partnership with the R&D Sciex, Toronto and is called “Scout-SRM”
Cortejade, Aurélie. "Approches et outils pour l’évaluation de l’Exposome : du dosage de contaminants vers le screening non ciblé pour la caractérisation des expositions humaines environnementales." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10219/document.
These research works highlight the development of analytical methods, based on mass spectrometry, to assess the Exposome according to different strategies. A selective multiresidue method for the analysis of plastic additives and their degradation products that may be released by plastic packaging in food and beverages and thus ingested by man was developed. This method consists of a Stir Bar Sorptive Extraction with bars covered by polydimethylsiloxane derivatives, followed by an analysis by liquid chromatography coupled to tandem mass spectrometry with a triple quadrupole instrument. To detect and quantify a wide range of contaminants in contact with man in daily routine, a screening method was developed by liquid chromatography coupled to high resolution mass spectrometry with a quadrupole-time-of-flight instrument from urinary matrix. The targeted screening method validated according to FDA guidelines allows the quantification of contaminants classified according to different families, in urine without sample preparation, at concentrations of the order of ng.mL-1. This method was applied to volunteers’ urine samples. The non-targeted screening method allows issuing numerous assumptions of compound identification after MS/MS fragmentation. The implementation of this tool to measure the Exposome associated with statistical studies, contribute greatly to the understanding of the causal relationships between diseases and environmental factors
Pereira, Hélène. "Développement de l'approche métabolomique par couplage chromatographie liquide / spectrométrie de masse : application à la nutrition." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2010. http://tel.archives-ouvertes.fr/tel-00719399.
Jaffuel, Aurore. "Résolution de mélanges complexes d'oligosaccharides sulfatés par chromatographie 2D et spectrométrie de masse : application aux héparines thérapeutiques." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1150.
Delalande, François. "Application du couplage chromatographie liquide-spectrométrie de masse à l'étude de la biodisponibilité de peptides issus de produits laitiers et à la protéomique." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13068.
The LC-MS coupling has arisen as a method of choice for the quantification of molecules in a matrix, the determination of the primary sequences of peptides and proteins and for the establishment of post-traductional modifications. The progress realized both at the LC and at the MS level have revolutionized the biology allowing the identification of femtomolar amounts of proteins separated by 2-D electrophoresis in the context of proteomic studies and the detection of molecules of interest with always more sensibility for example in biological fluids (plasma, urine, cerebro-spinal liquid)My PhD work consisted in the choice and the perfecting of instrumental and analytical strategies by a deep optimisation of alls the parameters of the LC-MS and LC-MS-MS coupling. The first part relates to the experimental perfecting of the microLC-MS(-MS) technics for the characterization of peptidic compounds and the measurement of their biodisponibility. The second part focuses on the development, the optimisation and the use of the nanoLC-MS-MS for proteomic studies with a first proteomic study aimed at characterizing the interactions between rice and the rice yellow mottle virus. This work has permitted, thanks to Maldi-MS and LC-MS-MS technics, to show up the rice proteins that are recruited by the capsid proteins of the virus and to identify the proteins differentially expressed depending an the rice cultivars (resistant/sensitive). The second proteomic study concerns the characterization of expression markers linked to the abnormality "Mantled" by the oil palm needing de novo sequencing. To conclude, we have used the multiple potentialities of the microLC-MS and the nanoLC-MS-MS coupling to reply to diverse biological problems. These responses could have been obtained only thanks to the perfecting of particular methodologies
Книги з теми "Chromatographie phase liquide spectrométrie de masse":
Niessen, Wilfried M. A. Liquid Chromatography-Mass Spectrometry. Hoboken: Taylor & Francis Ltd., 2006.
Niessen, W. M. A. Liquid chromatography--mass spectrometry: Principles and applications. New York: M. Dekker, 1992.
Niessen, W. M. A. Liquid chromatography--mass spectrometry. 3rd ed. Boca Raton: CRC/Taylor & Francis, 2006.
Niessen, W. M. A. Liquid chromatography-mass spectrometry. 2nd ed. New York: M. Dekker, 1999.
Rosenberg. Mass spectrometry and gas chromatography. New Delhi, India: Rajat Publications, 2003.
L, Yergey Alfred, ed. Liquid chromatography/mass spectrometry: Techniques and applications. New York: Plenum Press, 1990.
Karl, Pfleger. Mass spectral and GC data of drugs, poisons, pesticides, pollutants, and their metabolites. 2nd ed. Weinheim: VCH, 1992.
Kromidas, Stavros. HPLC-MS Handbook for Practitioners. Wiley & Sons, Incorporated, John, 2017.
Kromidas, Stavros. HPLC-MS Handbook for Practitioners. Wiley & Sons, Limited, John, 2017.
Kromidas, Stavros. HPLC-MS Handbook for Practitioners. Wiley & Sons, Incorporated, John, 2017.