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Добірка наукової літератури з теми "CEP1"

Автор: Grafiati
Опубліковано: 19 жовтня 2024

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Статті в журналах з теми "CEP1"

1

Meluh, P. B., and D. Koshland. "Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C." Molecular Biology of the Cell 6, no. 7 (July 1995): 793–807. http://dx.doi.org/10.1091/mbc.6.7.793.

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Анотація:
The MIF2 gene of Saccharomyces cerevisiae has been implicated in mitosis. Here we provide genetic evidence that MIF2 encodes a centromere protein. Specifically, we found that mutations in MIF2 stabilize dicentric minichromosomes and confer high instability (i.e., a synthetic acentric phenotype) to chromosomes that bear a cis-acting mutation in element I of the yeast centromeric DNA (CDEI). Similarly, we observed synthetic phenotypes between mutations in MIF2 and trans-acting mutations in three known yeast centromere protein genes-CEP1/CBF1/CPF1, NDC10/CBF2, and CEP3/CBF3B. In addition, the mif2 temperature-sensitive phenotype can be partially rescued by increased dosage of CEP1. Synthetic lethal interactions between a cep1 null mutation and mutations in either NDC10 or CEP3 were also detected. Taken together, these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein-DNA complex. The Mif2 and Cep1 proteins contain motifs of known transcription factors, suggesting that assembly of the yeast centromere is analogous to that of eukaryotic enhancers and origins of replication. We also show that the predicted Mif2 protein shares two short regions of homology with the mammalian centromere Ag CENP-C and that two temperature-sensitive mutations in MIF2 lie within these regions. These results provide evidence for structural conservation between yeast and mammalian centromeres.
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2

Baker, Richard E., Kendra Harris, and Keming Zhang. "Mutations Synthetically Lethal with cep1 Target S. cerevisiae Kinetochore Components." Genetics 149, no. 1 (May 1, 1998): 73–85. http://dx.doi.org/10.1093/genetics/149.1.73.

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Abstract CP1 (encoded by CEP1) is a Saccharomyces cerevisiae chromatin protein that binds a DNA element conserved in centromeres and in the 5′-flanking DNA of methionine biosynthetic (MET) genes. Strains lacking CP1 are defective in chromosome segregation and MET gene transcription, leading to the hypothesis that CP1 plays a general role in assembling higher order chromatin structures at genomic sites where it is bound. A screen for mutations synthetically lethal with a cep1 null allele yielded five recessive csl (cep1 synthetic lethal) mutations, each defining a unique complementation group. Four of the five mutations synergistically increased the loss rate of marker chromosomes carrying a centromere lacking the CP1 binding site, suggesting that the cep1 synthetic lethality was due to chromosome segregation defects. Three of these four CSL genes were subsequently found to be known or imputed kinetochore genes: CEP3, NDC10, and CSE4. The fourth, CSL4, corresponded to ORF YNL232w on chromosome XIV, and was found to be essential. A human cDNA was identified that encoded a protein homologous to Csl4 and that complemented the csl4-1 mutation. The results are consistent with the view that the major cellular role of CP1 is to safeguard the biochemical integrity of the kinetochore.
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3

O'Connell, K. F., and R. E. Baker. "Possible cross-regulation of phosphate and sulfate metabolism in Saccharomyces cerevisiae." Genetics 132, no. 1 (September 1, 1992): 63–73. http://dx.doi.org/10.1093/genetics/132.1.63.

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Анотація:
Abstract CP1 (encoded by the gene CEP1) is a sequence-specific DNA binding protein of Saccharomyces cerevisiae that recognizes a sequence element (CDEI) found in both yeast centromeres and gene promoters. Strains lacking CP1 exhibit defects in growth, chromosome segregation and methionine biosynthesis. A YEp24-based yeast genomic library was screened for plasmids which suppressed the methionine auxotrophy of a cep1 null mutant. The suppressing plasmids contained either CEP1 or DNA derived from the PHO4 locus. Subcloning experiments confirmed that suppression correlated with increased dosage of PHO4. PHO4c, pho80 and pho84 mutations, all of which lead to constitutive activation of the PHO4 transcription factor, also suppressed cep1 methionine auxotrophy. The suppression appeared to be a direct effect of PHO4, not a secondary effect of PHO regulon derepression, and was PHO2-dependent. Spontaneously arising extragenic suppressors of cep1 methionine auxotrophy were also isolated; approximately one-third of them were alleles of pho80. While PHO4 overexpression suppressed the methionine auxotrophy of a cep1 mutant, CEP1 overexpression failed to suppress the phenotype of a pho4 mutant; however, a cep1 null mutation suppressed the low inorganic phosphate growth deficiency of a pho84 mutant. The results may suggest that phosphate and sulfate metabolism are cross-regulated.
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4

Masison, D. C., and R. E. Baker. "Meiosis in Saccharomyces cerevisiae mutants lacking the centromere-binding protein CP1." Genetics 131, no. 1 (May 1, 1992): 43–53. http://dx.doi.org/10.1093/genetics/131.1.43.

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Анотація:
Abstract CP1 (encoded by the CEP1 gene) is a centromere binding protein of Saccharomyces cerevisiae that binds to the conserved DNA element I (CDEI) of yeast centromeres. To investigate the function of CP1 in yeast meiosis, we analyzed the meiotic segregation of CEN plasmids, nonessential chromosome fragments (CFs) and chromosomes in cep1 null mutants. Plasmids and CFs missegregated in 10-20% of meioses with the most frequent type of aberrant event being precocious sister segregation at the first meiotic division; paired and unpaired CFs behaved similarly. An unpaired chromosome I homolog (2N + 1) also missegregated at high frequency in the cep1 mutant (7.6%); however, missegregation of other chromosomes was not detected by tetrad analysis. Spore viability of cep1 tetrads was significantly reduced, and the pattern of spore death was nonrandom. The inviability could not be explained solely by chromosome missegregation and is probably a pleiotropic effect of cep1. Mitotic chromosome loss in cep1 strains was also analyzed. Both simple loss (1:0 segregation) and nondisjunction (2:0 segregation) were increased, but the majority of loss events resulted from nondisjunction. We interpret the results to suggest that CP1 generally promotes chromatid-kinetochore adhesion.
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5

Alunno, A., O. Bistoni, F. Pratesi, F. Topini, I. Puxeddu, V. Valentini, G. Cafaro, E. Bartoloni, P. Migliorini, and R. Gerli. "Association between anti-citrullinated alpha enolase antibodies and clinical features in a cohort of patients with rheumatoid arthritis: a pilot study." Reumatismo 70, no. 2 (July 6, 2018): 67. http://dx.doi.org/10.4081/reumatismo.2018.1028.

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Анотація:
In recent years several antibodies against citrullinated peptides (ACPAs) have been identified in patients with rheumatoid arthritis (RA) and their pathogenic, diagnostic and prognostic significance is under intense investigation. Among ACPAs, those targeting citrullinated alpha enolase (anti-CEP1) have been identified in RA but data about their ability to predict the development of erosive disease are conflicting. Furthermore, no data are currently available concerning their possible association with extra-articular manifestations (EAMs) in RA. The aim of this study was to investigate the prevalence and significance of anti-CEP1 from a prognostic point of view. In this pilot study we confirmed that anti-CEP1 Abs are associated with higher prevalence of bone erosions, but we also provided the first evidence of an association between anti-CEP1 Abs and RA interstitial lung disease (ILD). These results provide the basis to investigate the association between anti-CEP1 Abs and EAMs in larger cohorts of RA patients to possibly confirm its role as biomarker for RA-ILD.
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6

Baker, R. E., and D. C. Masison. "Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1." Molecular and Cellular Biology 10, no. 6 (June 1990): 2458–67. http://dx.doi.org/10.1128/mcb.10.6.2458-2467.1990.

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Анотація:
CP1 is a sequence-specific DNA-binding protein of the yeast Saccharomyces cerevisiae which recognizes the highly conserved DNA element I (CDEI) of yeast centromeres. We cloned and sequenced the gene encoding CP1. The gene codes for a protein of molecular weight 39,400. When expressed in Escherichia coli, the CP1 gene directed the synthesis of a CDEI-binding protein having the same gel mobility as purified yeast CP1. We have given the CP1 gene the genetic designation CEP1 (centromere protein 1). CEP1 was mapped and found to reside on chromosome X, 2.0 centimorgans from SUP4. Strains were constructed in which most of CEP1 was deleted. Such strains lacked detectable CP1 activity and were viable; however, CEP1 gene disruption resulted in a 35% increase in cell doubling time and a ninefold increase in the rate of mitotic chromosome loss. An unexpected consequence of CP1 gene disruption was methionine auxotrophy genetically linked to cep1. This result and the recent finding that CDEI sites in the MET25 promoter are required to activate transcription (D. Thomas, H. Cherest, and Y. Surdin-Kerjan, J. Mol. Biol. 9:3292-3298, 1989) suggest that CP1 is both a kinetochore protein and a transcription factor.
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7

Baker, R. E., and D. C. Masison. "Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1." Molecular and Cellular Biology 10, no. 6 (June 1990): 2458–67. http://dx.doi.org/10.1128/mcb.10.6.2458.

Повний текст джерела
Анотація:
CP1 is a sequence-specific DNA-binding protein of the yeast Saccharomyces cerevisiae which recognizes the highly conserved DNA element I (CDEI) of yeast centromeres. We cloned and sequenced the gene encoding CP1. The gene codes for a protein of molecular weight 39,400. When expressed in Escherichia coli, the CP1 gene directed the synthesis of a CDEI-binding protein having the same gel mobility as purified yeast CP1. We have given the CP1 gene the genetic designation CEP1 (centromere protein 1). CEP1 was mapped and found to reside on chromosome X, 2.0 centimorgans from SUP4. Strains were constructed in which most of CEP1 was deleted. Such strains lacked detectable CP1 activity and were viable; however, CEP1 gene disruption resulted in a 35% increase in cell doubling time and a ninefold increase in the rate of mitotic chromosome loss. An unexpected consequence of CP1 gene disruption was methionine auxotrophy genetically linked to cep1. This result and the recent finding that CDEI sites in the MET25 promoter are required to activate transcription (D. Thomas, H. Cherest, and Y. Surdin-Kerjan, J. Mol. Biol. 9:3292-3298, 1989) suggest that CP1 is both a kinetochore protein and a transcription factor.
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Alunno, A., F. Carubbi, O. Bistoni, M. Antonucci, E. Bartoloni Bocci, R. Giacomelli, and R. Gerli. "FRI0565 PREVALENCE AND SIGNIFICANCE OF ANTIBODIES AGAINST CITRULLINATED ALPHA-ENOLASE (ANTI-CEP1) IN CONNECTIVE TISSUE DISEASES." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 885.2–885. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4549.

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Анотація:
Background:Anti-cyclic citrullinated peptide (anti-CCP) auto-antibodies represent the current gold standard for the diagnosis of rheumatoid arthritis (RA). However, growing evidence suggests that a variety of other citrullinated self-proteins may act as autoantigens and lead to the production of autoantibodies (1). Furthermore, autoantibodies believed to be RA-specific have been detected also in patients with connective tissue diseases (CTDs). We recently demonstrated that antibodies against citrullinated alpha-enolase (anti-CEP1) are a biomarker of erosive disease and RA-associated interstitial lung disease (2).Objectives:The purpose of this study was to investigate the prevalence and possible prognostic value of anti-CEP-1 in patients with CTDs.Methods:Two hundred and twelve consecutive patients with CTDs (51 systemic lupus erythematosus (SLE), 85 primary Sjogren’s syndrome (pSS) and 76 systemic sclerosis (SSc)) were studied and compared to 97 sex and age matched normal controls (NC) and 267 patients with RA. Anti-CEP1 IgG were detected in serum samples with a commercial ELISA kit (Euroimmun).Results:The overall prevalence of anti-CEP1 in CTDs was 7% (15/212 patients). In detail, these antibodies were detectable in 4 out of 85 pSS (5%), 5 out of 51 SLE (10%) and 6/76 SSc (8%). The prevalence and the titer of anti-CEP1 in CTDs was significantly higher compared to NC and significantly lower compared to RA. Anti-CEP1 positive patients did not display a specific clinical and serological picture. Unlike in RA, anti-CEP1 did not correlate with CTD-associated ILD.Conclusion:This is the first study assessing anti-CEP1 in a large cohort of patients with CTDs. We demonstrated that the association of these autoantibodies with ILD is specific for RA since it is not observed in SLE, pSS and SSc. Furthermore, although being significantly more prevalent and at higher titer compared to NC, anti-CEP1 do not allow to discriminate different patient subsets displaying peculiar clinical or serological phenotypes. Based on our results, the application of anti-CEP1 in CTDs is not advisable, however larger studies may possibly identify correlations not evident in our cohort.References:[1] Bonifacio AF, Alunno A, La Paglia GMC, Valentini E, Leone MC, Bartoloni E, Gerli R. Novel autoantibodies in rheumatoid arthritis. Reumatismo 2019;71(1):1-12[2] Alunno A, Bistoni O, Pratesi F, La Paglia GMC, Puxeddu I, Migliorini P, Gerli R. Anti-citrullinated alpha enolase antibodies, interstitial lung disease and bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2018;57(5):850-855Disclosure of Interests:Alessia Alunno: None declared, Francesco Carubbi Speakers bureau: Francesco Carubbi received speaker honoraria from Abbvie and Celgene outside this work., Onelia Bistoni: None declared, Matteo Antonucci: None declared, Elena Bartoloni Bocci: None declared, Roberto Giacomelli Grant/research support from: Actelion, Pfizer, Speakers bureau: Abbvie, Roche, Actelion, BMS, MSD, Ely Lilly, SOBI, Pfizer, Roberto Gerli: None declared
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Alunno, A., O. Bistoni, F. Carubbi, M. Antonucci, S. Calvacchi, E. Bartoloni Bocci, M. Zen, et al. "POS0755 PREVALENCE AND RELEVANCE OF ANTIBODIES AGAINST CITRULLINATED ALPHA ENOLASE (ANTI-CEP1) IN CONNECTIVE TISSUE DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 630.1–630. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2825.

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Анотація:
Background:Anti-citrullinated alpha enolase antibodies have been investigated in rheumatoid arthritis and associated with bone erosion and interstitial lung disease but little is known about their prevalence and role in connective tissue diseases (CTDs).Objectives:The aim of this study was to investigate the prevalence and relevance of anti-CEP1 antibodies in CTDs.Methods:Serum samples from five independent patient cohorts were assessed: 1) established (est) primary Sjogren’s syndrome (pSS) N=78, 2) est-systemic lupus erythematosus (SLE) N=52, 3) est-systemic sclerosis (SSc) N=71, 4) pSS at disease onset N=30, 5) SLE at disease onset N=46 (cohorts 4 and 5 had at least 3 years of follow-up). Samples from ninety sex and age matched healthy donors (HD) and 200 patients with est-RA (disease controls) were also tested. Anti-CEP1 IgG antibodies were measured with a commercially available ELISA kit (Euroimmun, Luebeck, Germany).Results:Anti-CEP1 titer was significantly higher in est-pSS, est-SLE and est-SSc compared to HD, significantly lower in est-pSS and est-SSc compared to est-RA and comparable in est-SLE versus est-RA. We divided patients in every CTD group based on whether their anti-CEP1 titer was below or above the 25th, 50th and 75th percentile. In est-SLE anti-CEP1 values over the 25th percentile were associated with articular involvement (odds ratio, OR (95% confidence interval, CI)=11.5; 1.9-70.6, p=0.008). In est-pSS, no relationship between anti-CEP1>25th percentile and articular involvement was found but rather an association with rheumatoid factor positivity (OR (95% CI)=4.8, 1.6-14.1, p=0.004) and salivary gland swelling (OR (95% CI)=6.2, 1.3-29.1, p=0.021). In est-SSc no difference could be detected across the 3 groups. Anti-CEP-1 titers in pSS and SLE at onset did not differ from each other, were comparable also to those of HD and significantly lower than those of est-pSS, est-SLE and est-RA patients (all p<0.0001).). Of interest, we could retrieve a serum sample collected at the time of diagnosis for 5 patients from the cohort of established pSS and we observed that anti-CEP1 titers were significantly lower at pSS onset than during follow up (at least 12 months after the diagnosis, p=0.0024). No difference was observed in the clinical presentation at disease onset according to different anti-CEP1 titer and they did not predict the development of new clinical manifestations during follow-up.Conclusion:Anti-CEP-1 antibodies can be detected in CTDs at different title during the disease course and may increase overtime, at least in pSS. Although anti-CEP1 antibodies are associated with specific clinical manifestation in est-CTDs, such as articular involvement in est-SLE, they seem to lack a predictive value for future manifestations when measured at disease onset.References:[1]Alunno A, Bistoni O, Pratesi F et al Rheumatology (Oxford) 2018.[2]Manca ML, Alunno A, D’Amato C et al. Joint Bone Spine 2018.Disclosure of Interests:None declared
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Guo, Xiaorui, Lihong Li, Xiatong Liu, Chong Zhang, Xiaoyun Yao, Zhili Xun, Zhijing Zhao, et al. "MYB2 Is Important for Tapetal PCD and Pollen Development by Directly Activating Protease Expression in Arabidopsis." International Journal of Molecular Sciences 23, no. 7 (March 24, 2022): 3563. http://dx.doi.org/10.3390/ijms23073563.

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Анотація:
Tapetal programmed cell death (PCD) is a complex biological process that plays an important role in pollen formation and reproduction. Here, we identified the MYB2 transcription factor expressed in the tapetum from stage 5 to stage 11 that was essential for tapetal PCD and pollen development in Arabidopsis thaliana. Downregulation of MYB2 retarded tapetal degeneration, produced defective pollen, and decreased pollen vitality. EMSA and transcriptional activation analysis revealed that MYB2 acted as an upstream activator and directly regulated expression of the proteases CEP1 and βVPE. The expression of these proteases was lower in the buds of the myb2 mutant. Overexpression of either/both CEP1 or/and βVPE proteases partially recover pollen vitality in the myb2 background. Taken together, our results revealed that MYB2 regulates tapetal PCD and pollen development by directly activating expression of the proteases CEP1 and βVPE. Thus, a transcription factor/proteases regulatory and activated cascade was established for tapetal PCD during another development in Arabidopsis thaliana. Highlight: MYB2 is involved in tapetal PCD and pollen development by directly regulating expression of the protease CEP1 and βVPE and establishes a transcription factor/proteases regulatory and activated cascade.
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Більше джерел

Дисертації з теми "CEP1"

1

Delobel, Valentin. "Identification de la protéine "Mutated in Colorectal Cancer" (MCC) comme un nouvel acteur de la voie WNT dans l'organisation polaire du plexus." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0137.

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Анотація:
La signalisation Wnt joue un rôle clé dans le développement d'un plexus vasculaire fonctionnel, assurant ainsi l'homéostasie des tissus. Son dysfonctionnement peut conduire à des pathologies vasculaires telles que les rétinopathies ou les démences. Cependant, les mécanismes moléculaires par lesquels cette voie régule l'architecture vasculaire restent encore mal compris. Dans cette étude, nous avons identifié la protéine « Mutated in Colorectal Cancer » (MCC) comme un nouveau composant de la voie Wnt non canonique de polarité planaire(PCP) dans les cellules endothéliales (CE). In vitro, nous avons démontré que MCC est une cible directe de la caséine kinase 1ε (CKIε), un régulateur clé de la voie Wnt, sous la stimulation par Wnt5a, un ligand de la voie Wntnon canonique.La suppression de MCC par une stratégie de siRNA perturbe la polarisation et la migration dirigée des CE cultivéessous flux laminaire. Pour élucider les mécanismes par lesquels MCC régule la polarité des CE pendant la migration,nous avons utilisé une stratégie de criblage différentiel (BioID) avec une protéine de fusion BirA*-MCC exprimée dans des CE. Grâce à cette approche, nous avons montré que MCC interagit avec des protéines centrosomales,notamment CEP131. MCC régule le niveau protéique de CEP131 par un mécanisme d’autophagie, ce processus étant contrôlé par l'activation de CK1ε. De plus, nous avons démontré que la restauration de la polarité et de la migration dans les cellules endothéliales traitées avec un siRNA ciblant MCC est possible en inhibant la surexpression de CEP131. Nous proposons ainsi un modèle où l'activation de MCC, médiée par Wnt5a/CK1ε, est essentielle pour maintenir les niveaux de CEP131 dans les CE, ce qui est crucial pour l’organisation polarisée de l'appareil de Golgi pendant la migration dirigée des cellules endothéliales sous conditions de flux. Pour étudier l'implication de MCC dans le développement vasculaire, nous avons spécifiquement déplété MCC dans les CE de souris (McciECKO). Six jours après la naissance (P6), les souriceaux mutants McciECKO présentent un retard significatif dans le développement vasculaire rétinien avec un réseau vasculaire moins dense, caractérisé par une réduction de la prolifération et une augmentation de la régression vasculaire. Afin d’analyser les défauts de polarisations des souris mutantes, nous les avons croisées avec des souris rapporteur GNrep. Au niveau du front de migration, les souriceaux mutants McciECKO présentent des défauts majeurs de polarisation et demigration des Tip Cells. Nous avons émis l'hypothèse que les CE des souris McciECKO étaient plus sensibles au flux. In vitro, dans les CE exposées au flux laminaire, la perte de MCC entraîne une augmentation importante de l'expression de KLF2, facteur de transcription majeur de réponse aux stress de cisaillement. Les souriceaux ont été traités avec du Captopril, afin de diminuer la pression artérielle. Ce traitement restaure la densité vasculairechez les souris McciECKO mais ne réverse pas les défauts de polarité des CE au front de migration. En résumé, nos résultats révèlent MCC comme un nouvel acteur de la voie Wnt non canonique PCP dans les CE, contribuant à la maturation dynamique et à la formation des vaisseaux sanguins. MCC contrôlerait la stabilité et la fonction des centrosomes, qui sont essentiels pour la migration polarisée des CE. Nos données montrent le double rôle de la voie Wnt non canonique, à la fois dans l'adaptation structurelle des cellules endothéliales et dans leurs fonctions mécano-sensorielles, essentielles pour un développement et un remodelage vasculaire appropriés
Wnt signalling plays a key role in the development of a functional vascular plexus, ensuring tissue homeostasis.Its dysfunction can lead to vascular pathologies such as retinopathy and dementia. However, the molecularmechanisms by which this pathway regulates vascular architecture remain poorly understood. In this study, weidentified the Mutated in Colorectal Cancer (MCC) protein as a novel component of the planar cell polarity (PCP)non-canonical Wnt pathway in endothelial cells (ECs). In vitro, we demonstrated that MCC is a direct target ofcasein kinase 1ε (CKIε), a key regulator of the Wnt pathway, under stimulation by Wnt5a, a ligand of the non-canonical Wnt pathway.Suppression of MCC by an siRNA strategy disrupts polarisation and directed migration of ECs cultured underlaminar flow. To elucidate the mechanisms by which MCC regulates EC polarity during migration, we used adifferential screening (BioID) strategy with a BirA*-MCC fusion protein expressed in ECs. Using this approach, weshowed that MCC interacts with centrosomal proteins, in particular CEP131. MCC regulates the protein level ofCEP131 by an autophagy mechanism, this process being controlled by the activation of CK1ε. Furthermore, wehave demonstrated that restoration of polarity and migration in endothelial cells treated with siRNA targetingMCC is possible by inhibiting CEP131 overexpression. We thus propose a model where Wnt5a/CK1ε-mediatedactivation of MCC is essential to maintain CEP131 levels in ECs, which is crucial for polarised Golgi apparatusorganisation during directed endothelial cell migration under flow conditions.To investigate the involvement of MCC in vascular development, we specifically depleted MCC in mouse ECs(McciECKO). Six days after birth (P6), McciECKO mutant mice show a significant delay in retinal vascular developmentwith a less dense vascular network, characterised by a reduction in proliferation and an increase in vascularregression. To analyse the polarisation defects in the mutant mice, we crossed them with GNrep reporter mice.At the migration front, McciECKO mutant mice showed major defects in Tip Cells’ polarisation and migration. Wehypothesised that ECs from McciECKO mice were more sensitive to flow. In vitro, in ECs exposed to laminar flow,loss of MCC resulted in a significant increase in the expression of KLF2, a major transcription factor in responseto shear stress. The mice were treated with Captopril to reduce arterial pressure. This treatment restored vasculardensity in McciECKO mice, but did not reverse EC polarity defects at the migration front.In summary, our results reveal MCC as a novel player in the non-canonical PCP Wnt pathway in ECs, contributingto dynamic maturation and blood vessel formation. MCC is thought to control the stability and function ofcentrosomes, which are essential for polarised EC migration. Our data demonstrate the dual role of the non-canonical Wnt pathway, both in the structural adaptation of endothelial cells and in their mechanosensoryfunctions, which are essential for proper vascular development and remodelling
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2

Gladys, Arias Lazarte Elizabeth, Alva Cabrera Ruben Jesus, Villalobos Solano Juan Javier, and Acosta Neyra Jesus Manuel. "Matemática Básica (Epe)-CE11-201201." Universidad Peruana de Ciencias Aplicadas (UPC), 2012. http://hdl.handle.net/10757/636869.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. Los temas que se desarrollan en este curso sonLógica proposicional/ Operaciones en conjuntos numéricos / Valor Absoluto / Fracciones / Proporcionalidad / Porcentaje / Expresiones algebraicas / Potenciación / Productos notables / Factorización / Expresiones racionales / Ecuaciones de primer y segundo grado / Ecuaciones polinómicas / Sistemas de ecuaciones lineales con dos variables / Inecuaciones de primer grado / Ecuaciones e Inecuaciones Racionales / Sistema de coordenadas rectangulares / Funciones / Operaciones con funciones / Función inversa / Modelación con funciones / Logaritmos en bases 10 e y 2 / Cambio de base / Operaciones / Funciones exponencial y logarítmica / Funciones trigonométricas /
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Walter, De La Cruz Sanchez Alejandro, Arias Lazarte Elizabeth Gladys, and Alva Cabrera Ruben Jesus. "Matemática Básica (Epe)-CE11-201202." Universidad Peruana de Ciencias Aplicadas (UPC), 2012. http://hdl.handle.net/10757/636870.

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El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. Los temas que se desarrollan en este curso sonLógica proposicional/ Operaciones en conjuntos numéricos / Valor Absoluto / Fracciones / Proporcionalidad / Porcentaje / Expresiones algebraicas / Potenciación / Productos notables / Factorización / Expresiones racionales / Ecuaciones de primer y segundo grado / Ecuaciones polinómicas / Sistemas de ecuaciones lineales con dos variables / Inecuaciones de primer grado / Ecuaciones e Inecuaciones Racionales / Sistema de coordenadas rectangulares / Funciones / Operaciones con funciones / Función inversa / Modelación con funciones / Logaritmos en bases 10 e y 2 / Cambio de base / Operaciones / Funciones exponencial y logarítmica / Funciones trigonométricas /
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Walter, De La Cruz Sanchez Alejandro, Arias Lazarte Elizabeth Gladys, Alva Cabrera Ruben Jesus, Villalobos Solano Juan Javier, and Malaver Ortega Johnny Alberto. "Matemática Básica (Epe)-CE11-201300." Universidad Peruana de Ciencias Aplicadas (UPC), 2012. http://hdl.handle.net/10757/636871.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. Los temas que se desarrollan en este curso sonLógica proposicional/ Operaciones en conjuntos numéricos / Valor Absoluto / Fracciones / Proporcionalidad / Porcentaje / Expresiones algebraicas / Potenciación / Productos notables / Factorización / Expresiones racionales / Ecuaciones de primer y segundo grado / Ecuaciones polinómicas / Sistemas de ecuaciones lineales con dos variables / Inecuaciones de primer grado / Ecuaciones e Inecuaciones Racionales / Sistema de coordenadas rectangulares / Funciones / Operaciones con funciones / Función inversa / Modelación con funciones / Logaritmos en bases 10 e y 2 / Cambio de base / Operaciones / Funciones exponencial y logarítmica / Funciones trigonométricas /
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Alberto, Maldonado Carrasco David, Arias Lazarte Elizabeth Gladys, Alva Cabrera Ruben Jesus, Mamani Suaquita Juana, and Arauco Lugo Christian Alexander. "Matemática Básica (Epe)-CE11-201301." Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/636872.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. A través de este curso los estudiantes podrán desarrollar las estrategias y habilidades necesarias para la resolución de problemas relacionados con los temas de álgebra elemental ecuaciones e inecuaciones de diversos tipos que le servirán de base para el estudio de las funciones algebraicas y trascendentales tales como las funciones polinómicas función valor absoluto funciones seccionadas función inversa funciones exponenciales funciones logarítmicas funciones trigonométricas y su aplicación en la modelación de problemas reales relacionados con la ingeniería.
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Walter, De La Cruz Sanchez Alejandro, Maldonado Carrasco David Alberto, Arias Lazarte Elizabeth Gladys, Villalobos Solano Juan Javier, and Toribio Cangana Manuel Teodosio. "Matemática Básica (Epe)-CE11-201302." Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/636873.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. A través de este curso los estudiantes podrán desarrollar las estrategias y habilidades necesarias para la resolución de problemas relacionados con los temas de álgebra elemental ecuaciones e inecuaciones de diversos tipos que le servirán de base para el estudio de las funciones algebraicas y trascendentales tales como las funciones polinómicas función valor absoluto funciones seccionadas función inversa funciones exponenciales funciones logarítmicas funciones trigonométricas y su aplicación en la modelación de problemas reales relacionados con la ingeniería.
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7

Walter, De La Cruz Sanchez Alejandro, Maldonado Carrasco David Alberto, Arias Lazarte Elizabeth Gladys, Villalobos Solano Juan Javier, and Acosta Neyra Jesus Manuel. "Matemática Básica (Epe)-CE11-201400." Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/636874.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. A través de este curso los estudiantes podrán desarrollar las estrategias y habilidades necesarias para la resolución de problemas relacionados con los temas de álgebra elemental ecuaciones e inecuaciones de diversos tipos que le servirán de base para el estudio de las funciones algebraicas y trascendentales tales como las funciones polinómicas función valor absoluto funciones seccionadas función inversa funciones exponenciales funciones logarítmicas funciones trigonométricas y su aplicación en la modelación de problemas reales relacionados con la ingeniería.
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8

Walter, De La Cruz Sanchez Alejandro, Maldonado Carrasco David Alberto, Villalobos Solano Juan Javier, Toribio Cangana Manuel Teodosio, and Mamani Suaquita Juana. "Matemática Básica (Epe)-CE11-201401." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/636875.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. A través de este curso los estudiantes podrán desarrollar las estrategias y habilidades necesarias para la resolución de problemas relacionados con los temas de álgebra elemental ecuaciones e inecuaciones de diversos tipos que le servirán de base para el estudio de las funciones algebraicas y trascendentales tales como las funciones polinómicas función valor absoluto funciones seccionadas función inversa funciones exponenciales funciones logarítmicas funciones trigonométricas y su aplicación en la modelación de problemas reales relacionados con la ingeniería.
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Walter, De La Cruz Sanchez Alejandro, Villalobos Solano Juan Javier, Toribio Cangana Manuel Teodosio, and Mamani Suaquita Juana. "Matemática Básica (Epe)-CE11-201402." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/636876.

Повний текст джерела
Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. A través de este curso los estudiantes podrán desarrollar las estrategias y habilidades necesarias para la resolución de problemas relacionados con los temas de álgebra elemental ecuaciones e inecuaciones de diversos tipos que le servirán de base para el estudio de las funciones algebraicas y trascendentales tales como las funciones polinómicas función valor absoluto funciones seccionadas función inversa funciones exponenciales funciones logarítmicas funciones trigonométricas y su aplicación en la modelación de problemas reales relacionados con la ingeniería.
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10

Walter, De La Cruz Sanchez Alejandro, Maldonado Carrasco David Alberto, Sanchez Espinoza Julio Alfredo, Villalobos Solano Juan Javier, and Mamani Suaquita Juana. "Matemática Básica (Epe)-CE11-201500." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/636877.

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Анотація:
El curso de Matemática Básica es la base de todos los cursos de la línea de matemática para las carreras de Ingeniería los mismos que sirven a su vez de soporte para las asignaturas propias de cada especialidad. A través de este curso los estudiantes podrán desarrollar las estrategias y habilidades necesarias para la resolución de problemas relacionados con los temas de álgebra elemental ecuaciones e inecuaciones de diversos tipos que le servirán de base para el estudio de las funciones algebraicas y trascendentales tales como las funciones polinómicas función valor absoluto funciones seccionadas función inversa funciones exponenciales funciones logarítmicas funciones trigonométricas y su aplicación en la modelación de problemas reales relacionados con la ingeniería.
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Книги з теми "CEP1"

1

Proyek Pengembangan Pemasyarakatan Potensi Perdagangan Intenasional (Indonesia), ed. Perkembangan CEPT-AFTA. [Jakarta]: Proyek Pengembangan Pemasyarakatan Potensi Perdagangan Internasional, Direktorat Hubungan Perdagangan Multilateral dan Regional, Direktorat Jenderal Perdagangan Internasional, Departemen Perindustrian dan Perdagangan, 1998.

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Amaré, Fernando Bellver. La cepa mediterránea. Madrid: Nóesis, 1999.

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N, Chudžcenko A., ed. Zolotaja cep'. Simferopol': Tavrija, 1988.

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4

Yedla, Sudhakar, and Choongjae Cho. The India–Korea CEPA. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-2928-9.

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5

(Canada), CEPA Office, ed. Reviewing CEPA: The issues. Hull, Quebec: The Office, 1994.

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6

Anne-Caroline, Biancheri, Micale Adriana, and Correas Jaime 1961-, eds. Mendoza, de pura cepa. Buenos Aires, Argentina: Caviar Bleu, 2001.

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7

Czech Republic) Centrum pro ekonomiku a politiku (Prague. Autoři CEPu o euru. Praha: CEP - Centrum pro ekonomiku a politiku, 2010.

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Dalton, Russell J. Elites, Issues, and Political Cleavages. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198830986.003.0005.

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Political parties define the supply of policy choices for voters. This chapter uses the three Candidates to the European Parliament (CEP) studies to determine the political views of elites and thereby the policy positions of their respective parties. As for European citizens, CEPs’ issue opinions are structured by a two-dimensional space defined by the economic and cultural cleavages. The analyses also show that many of the demographic forces, such as social class or religious background, which reshaped public opinion, also influence the views of party elites on both cleavage dimensions. The chapter maps the distribution of national party elites on both cleavages. The analyses are based on CEP studies in 1979, 1994, and 2009.
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Cepu, cepu kukuliti. Riga: Liesma, 1988.

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10

Ceph: Alliance. Independently Published, 2021.

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Частини книг з теми "CEP1"

1

van Roy, Frans, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, et al. "CED1." In Encyclopedia of Signaling Molecules, 386. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100242.

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2

Lim, T. K. "Allium cepa." In Edible Medicinal and Non Medicinal Plants, 124–203. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9511-1_4.

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Ross, Ivan A. "Allium cepa." In Medicinal Plants of the World, 1–35. Totowa, NJ: Humana Press, 2001. http://dx.doi.org/10.1007/978-1-59259-237-1_1.

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Bährle-Rapp, Marina. "Allium cepa." In Springer Lexikon Kosmetik und Körperpflege, 22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_358.

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Xu, Jun. "Case Study: Ceph." In Block Trace Analysis and Storage System Optimization, 209–27. Berkeley, CA: Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-3928-5_9.

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Khare, C. P. "Allium cepa Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_81.

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Sastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Allium cepa (Onion)." In Encyclopedia of Plant Viruses and Viroids, 57–65. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_27.

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Jain, Ishita, Harsh Bhavsar, and Gavin Keeney. "C'est la CEPT." In Performance Making and the Archive, 163–92. London: Routledge India, 2022. http://dx.doi.org/10.4324/9780429281921-16.

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Akbar, Shahid. "Allium cepa L. (Amaryllidaceae)." In Handbook of 200 Medicinal Plants, 139–60. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-16807-0_16.

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Kalmar, Jayne M., Brigid M. Lynch, Christine M. Friedenreich, Lee W. Jones, A. N. Bosch, Alessandro Blandino, Elisabetta Toso, et al. "Cardiopulmonary Exercise Testing (CEPT)." In Encyclopedia of Exercise Medicine in Health and Disease, 175. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2199.

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Тези доповідей конференцій з теми "CEP1"

1

Hanus, Václav, Beatrix Fehér, Zsuzsanna Pápa, Judit Budai, Pallabi Paul, Adriana Szeghalmi, and Péter Dombi. "Serial Carrier-Envelope Phase Detection and Modulation for PHz Optoelectronics." In CLEO: Fundamental Science, FW3B.7. Washington, D.C.: Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_fs.2024.fw3b.7.

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This study demonstrates a serialized carrier-envelope phase (CEP) measurement using a 250-nm 2D heterostructure, revealing measurable CEP shifts suitable for PHz optoelectronics, advancing the potential for CEP-based communication networks.
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Zhang, Qiaochu, Shiyu Su, Juzheng Liu, and Mike Shuo-Wei Chen. "CEPA." In ICCAD '20: IEEE/ACM International Conference on Computer-Aided Design. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3400302.3415686.

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Zhu, Yeshuang, Shichao Yue, Chun Yu, and Yuanchun Shi. "CEPT." In CSCW '17: Computer Supported Cooperative Work and Social Computing. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/2998181.2998306.

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desJardins, Marie, and Susan Martin. "CE21--Maryland." In Proceeding of the 44th ACM technical symposium. New York, New York, USA: ACM Press, 2013. http://dx.doi.org/10.1145/2445196.2445402.

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Liang, Zhijun. "Electroweak Physics at CEPC." In 38th International Conference on High Energy Physics. Trieste, Italy: Sissa Medialab, 2017. http://dx.doi.org/10.22323/1.282.0692.

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Li, Gang. "Detector optimization at CEPC." In 38th International Conference on High Energy Physics. Trieste, Italy: Sissa Medialab, 2017. http://dx.doi.org/10.22323/1.282.1164.

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Gao, Jie. "CEPC Accelerator Towards TDR." In 40th International Conference on High Energy physics. Trieste, Italy: Sissa Medialab, 2021. http://dx.doi.org/10.22323/1.390.0686.

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Zimmerle, Carlos, and Kiev Gama. "Reactive CEP." In WebMedia '18: Brazilian Symposium on Multimedia and the Web. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3243082.3267453.

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9

Priadi, S. N. "The Success of Managing Participating Interest (PI) in Cepu Block in Increasing Regional Revenue InEast Java." In Indonesian Petroleum Association 44th Annual Convention and Exhibition. Indonesian Petroleum Association, 2021. http://dx.doi.org/10.29118/ipa21-bc-99.

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The Cepu Block is one of the largest national oil and gas producers. State revenue from the oil and gas sector in the Cepu Block can also be used to increase revenue from oil and gas producing regions in East Java. This is based on PP. 35/2004 that regulates oil and gas contractors' obligations to offer 10% of Participating Interest (PI) to Regional-Owned Enterprises (BUMD). However, in reality, not all regions are ready to participate in PI financing due to regional financial limitations. PI of Cepu Block has been realized since 2009 where PT Petrogas Jawa Timur Utama Cendana (PJUC) became one of the four BUMD that assigned to manage the PI of 2.243% with share rights. Initially, PT Petrogas Jawa Timur Utama Cendana used the Public-Private Partnership (PPP) scheme with PT Raharja Energy Cepu (REC) as the initial capital for joining in Participating Interest (PI) of the Cepu Block. Thus, this paper will discuss PI management's success in the Cepu Block, starting from the preparation, procedures for bidding and transferring PIs to the formation of the BKS PI 10% Cepu Block. PJUC utilize part of the funds obtained from PI 10% to manage various business fields. With good management, PJUC has successfully gained USD 3.5 billion profit in 2020 and has successfully paid off its debts, and has become one of the BUMD with a large contribution of local revenue East Java Province. Having PJUC debt paid off, revenue in 2021 will reach around USD 13 billion. BUMD's exists to managing the Cepu Block oil and gas working area through the 10% of Participating Interest that provides an increase in regional revenue for East Java. It increases BUMD's knowledge in managing oil and gas blocks as a non-operator contractor. Then, Participating Interest can be creating transparency in lifting, reserves, and cost recovery. Besides, the regional-owned enterprise can also help facilitate or accelerate issuing permits needed in the regions and help implement cooperation contract activities in the areas.
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Кудрявцева, Н. А., Л. И. Хрусталева, С. В. Одинцов, А. М. Пивоваров, А. С. Ермолаев, and С. А. Симановский. "COMPARATIVE IMMUNOFLUORESCENCE ANALYSIS OF MEIOTIC PROTEINS (ASY1, ZYP1, MLH1, MUS81 and CENH3) IN ALLIUM CEPA AND ALLIUM FISTULOSUM." In Биотехнология в растениеводстве, животноводстве и сельскохозяйственной микробиологии, 128–29. Crossref, 2022. http://dx.doi.org/10.48397/arriab.2022.22.xxii.077.

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Большинство живых организмов имеют случайное распределение хиазм вдоль хромосом как у лука репчатого (A. cepa). И только немногие являются исключением! Таким исключением является лук-батун (A. fistulosum), у которого хиазмы строго локализованы в проксимальных областях хромосом. Хиазмы – цитологическое проявление кроссинговера. Диаметрально противоположное распределение хиазм возможно является причиной стерильности BC1 гибридов между A. cepa и A. fistulosum. Most living organisms have a random distribution of chiasmata along the chromosomes, like onions (A. cepa). And only a few are exceptions! Such an exception is the onion (A. fistulosum), in which the chiasmata are strictly localized in the proximal regions of the chromosomes. Chiasma is a cytological manifestation of crossing over. The diametrically opposed distribution of chiasmata may be the reason for the sterility of BC1 hybrids between A. cepa and A. fistulosum.
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Звіти організацій з теми "CEP1"

1

Wang, Feiyi, H. Sarp Oral, Douglas Fuller, Blake A. Caldwell, James A. Simmons, Bradley W. Settlemyer, Scott Atchley, Jason J. Hill, and Mark Nelson. Ceph Parallel File System Evaluation Report. Office of Scientific and Technical Information (OSTI), November 2013. http://dx.doi.org/10.2172/1104795.

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Jones, Byron. PR266-18201-R01 CEPM for Turbochargers. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), January 2023. http://dx.doi.org/10.55274/r0012250.

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Documents methods and data necessary to identify a decline in turbocharger performance based on real-time and near-real-time operating data. The techniques allow for the identification of performance issues well in advance of critical performance loss. This continuous equipment performance monitoring allows for a managed overhaul rather than an unplanned outage. The techniques were evaluated to determine their applicability to monitor performance of gas turbines with a focus on the axial compressor. The methods were verified against field data with induced abnormal operating conditions to validate the efficacy of the models and to help the equipment operators diagnose the underlying conditions contributing to the performance decline.
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Morales Castañeda, Alexis, Maria Nancy Moreno Valderrama, and Luz Andrea Yepes Vargas. Contexto de cadena cebolla de bulbo (Allium cepa). Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.fichascontexto.2020.25.

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En esta ficha de contexto se mencionan los aspectos importantes de la cadena de cebolla de bulbo (Allium cepa) enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
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4

Recalde, Alfredo. Taller: "Competitividad empresarial mediante normas ISO de sistema de gestión" y ¿Conseguir ecoeficiencia a través de una producción más limpia y una gestión ambiental¿. Inter-American Development Bank, June 2002. http://dx.doi.org/10.18235/0007291.

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Presentación sobre el Centro Ecuatoriano de Producción más Limpia (CEPL). Da a conocer los avances y resultados del CEPL, los convenios y proyectos suscritos, así como la participación del proyecto BID (FOMIN) - CEPL.
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King, David, Kurt Spies, James Rainbolt, and Keling Zhang. CAS-NETL-PNNL CEP Program Final Report. Office of Scientific and Technical Information (OSTI), March 2014. http://dx.doi.org/10.2172/1136614.

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Choquette, Gary. PR-000-16209-WEB Data Management Best Practices Learned from CEPM. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), April 2019. http://dx.doi.org/10.55274/r0011568.

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DATE: Wednesday, May 1, 2019 TIME: 2:00 - 3:30 p.m. ET PRESENTER: Gary Choquette, PRCI CLICK DOWNLOAD/BUY TO ACCESS THE REGISTRATION LINK FOR THIS WEBINAR Systems that manage large sets of data are becoming more common in the energy transportation industry. Having access to the data offers the opportunity to learn from previous experiences to help efficiently manage the future. But how does one manage to digest copious quantities of data to find nuggets within the ore? This webinar will outline some of the data management best practices learned from the research projects associated with CEPM. - Logging/capturing data tips - Techniques to identify 'bad' data - Methods of mapping equipment and associated regressions - Tips for pre-processing data for regressions - Machine learning tips - Establishing alarm limits - Identifying equipment problems - Multiple case studies Who Should Attend? - Data analysts - Equipment support specialists - Those interested in learning more about 'big data' and 'machine learning' Recommended Pre-reading: - PR-309-11202-R01 Field Demonstration Test of Advanced Engine and Compressor Diagnostics for CORE - PR-312-12210-R01 CEPM Monitoring Plan for 2SLB Reciprocating Engines* - PR-309-13208-R01 Field Demonstration of Integrated System and Expert Level Continuous Performance Monitoring for CORE* - PR-309-14209-R01 Field Demo of Integrated Expert Level Continuous Performance Monitoring - PR-309-15205-R01 Continuous Engine Performance Monitoring Technical Specification - PR-000-15208-R01 Reciprocating Engine Speed Stability as a Measure of Combustion Stability - PR-309-15209-R01 Evaluation of NSCR Specific Models for Use in CEPM - PR-000-16209-R01 Demonstration of Continuous Equipment Performance Monitoring - PR-015-17606-Z02 Elbow Meter Test Results* *Documents available to PRCI member only Attendance will be limited to the first 500 registrants to join the webinar. All remaining registrants will receive a link to view the recording after the webinar. Not able to attend? Register anyway to automatically receive a link to the recording after the webinar to view at your convenience! After registering, you will receive a confirmation email containing information about joining the webinar. Please visit our website for other webinars that may be of interest to you!
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Simonds, Jim, and Roxanne Constable. Crowd Control CEP Blunt Impact Induced Effectiveness Assessment. Fort Belvoir, VA: Defense Technical Information Center, July 2003. http://dx.doi.org/10.21236/ada416787.

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Bothwell and Beshouri. PR-309-13208-R01 Field Demonstration of the Benefits of Continuous Engine Performance Monitoring for CORE. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), February 2015. http://dx.doi.org/10.55274/r0010832.

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Prior PRCI funded projects, identified the ability of a Continuous Engine Performance Monitor, (CEPM) to fulfill the likelihood of industry acceptance as a Performance Monitoring alternative to a Continuous Emission Monitoring System CEMS in future monitoring requirements for typical pipeline engines. This current project installed a CEPM monitoring system on a pipeline engine equipped with a CEMS and assessed the ability of this CEPM system to detect potential engine emission excursions. In summary, successful implementation of a CEPM system requires functioning knowledge of the test engine in addition to well calibrated instrumentation. Characterization of Air Fuel Ratio (AFR) and combustion performance should be established with a preset check list of engine conditions which should be the standard prior to mapping and all data collection. This current CEPM project has shown that the use of AFR and combustion performance indicators can result in a cost efficient emission/performance monitoring tool.
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Chang, S. W., J. D. Scudder, J. F. Fennell, R. Friedel, and R. P. Lepping. Energetic Magnetosheath Ions Connected to the Earth's Bow Shock: Possible Source of CEPs. Fort Belvoir, VA: Defense Technical Information Center, December 2001. http://dx.doi.org/10.21236/ada399602.

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Beshouri, Greg, and Bob Goffin. PR-309-15209-R01 Evaluation of NSCR Specific Models for Use in CEPM. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), January 2019. http://dx.doi.org/10.55274/r0011554.

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This 2015 NSCR project continues NSCR research started in 2009 and continued in 2011 under ERLE 2c and combines it with OBD research started in 2008 and continued in 2011. The 2009 NSCR research concluded that downstream measurement of lambda, O2 and NOx are useful for understanding performance of the entire package and evaluating compliance status and diagnosing system problems. However, that research also concluded that advanced signal conditioning and algorithms are required for unambiguous diagnostics. It also concluded system diagnostics was complex and beyond the capabilities of typical technicians. The 2011 OBD project demonstrated that a model-based diagnostics approach could precisely detect and diagnose typical combustion faults on lean burn engines. This 2015 project will specifically test and demonstrate the effectiveness of model based NSCR diagnostics using upstream and downstream exhaust sensors and other typical sensor inputs.
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