Готові списки джерел за темами / Cell differentiation

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  1. Статті в журналах
  2. Дисертації
  3. Книги
  4. Частини книг
  5. Тези доповідей конференцій
  6. Звіти організацій

Добірка наукової літератури з теми "Cell differentiation"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 7 вересня 2024

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Статті в журналах з теми "Cell differentiation"

1

J, Otsuka. "A Theoretical Study on the Cell Differentiation Forming Stem Cells in Higher Animals." Physical Science & Biophysics Journal 5, no. 2 (2021): 1–10. http://dx.doi.org/10.23880/psbj-16000191.

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The recent genome sequencing of multicellular diploid eukaryotes reveals an enlarged repertoire of protein genes for signal transmission but it is still difficult to elucidate the network of signal transmission to drive the life cycle of such an eukaryote only from biochemical and genetic studies. In the present paper, a theoretical study is carried out for the cell differentiation, the formation of stem cells and the growth from a child to the adult in the higher animal. With the intercellular and intracellular signal transmission in mind, the cell differentiation is theoretically derived from the process by the transition of proliferated cells from proliferation mode to differentiation mode and by both the long-range interaction between distinctive types of cells and the short-range interaction between the same types of cells. As the hierarchy of cell differentiation is advanced, the original types of self-reproducible cells are replaced by the self-reproducible cells returned from the cells differentiated already. The latter type of self-reproducible cells are marked with the signal specific to the preceding differentiation and become the stem cells for the next stage of cell differentiation. This situation is realized under the condition that the differentiation of cells occurs immediately after their proliferation in the development. The presence of stem cells in the respective lineages of differentiated cells strongly suggests another signal transmission for the growth of a child to a definite size of adult that the proliferation of stem cells in one lineage is activated by the signal from the differentiated cells in the other lineage(s) and is suppressed by the signal from the differentiated cells in its own lineage. This style of signal transmission also explains the metamorphosis and maturation of germ cells in higher animals.
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2

Zhang, Yu, Patrick Babczyk, Andreas Pansky, Matthias Ulrich Kassack, and Edda Tobiasch. "P2 Receptors Influence hMSCs Differentiation towards Endothelial Cell and Smooth Muscle Cell Lineages." International Journal of Molecular Sciences 21, no. 17 (August 27, 2020): 6210. http://dx.doi.org/10.3390/ijms21176210.

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Background: Human mesenchymal stem cells (hMSCs) have shown their multipotential including differentiating towards endothelial and smooth muscle cell lineages, which triggers a new interest for using hMSCs as a putative source for cardiovascular regenerative medicine. Our recent publication has shown for the first time that purinergic 2 receptors are key players during hMSC differentiation towards adipocytes and osteoblasts. Purinergic 2 receptors play an important role in cardiovascular function when they bind to extracellular nucleotides. In this study, the possible functional role of purinergic 2 receptors during MSC endothelial and smooth muscle differentiation was investigated. Methods and Results: Human MSCs were isolated from liposuction materials. Then, endothelial and smooth muscle-like cells were differentiated and characterized by specific markers via Reverse Transcriptase-PCR (RT-PCR), Western blot and immunochemical stainings. Interestingly, some purinergic 2 receptor subtypes were found to be differently regulated during these specific lineage commitments: P2Y4 and P2Y14 were involved in the early stage commitment while P2Y1 was the key player in controlling MSC differentiation towards either endothelial or smooth muscle cells. The administration of natural and artificial purinergic 2 receptor agonists and antagonists had a direct influence on these differentiations. Moreover, a feedback loop via exogenous extracellular nucleotides on these particular differentiations was shown by apyrase digest. Conclusions: Purinergic 2 receptors play a crucial role during the differentiation towards endothelial and smooth muscle cell lineages. Some highly selective and potent artificial purinergic 2 ligands can control hMSC differentiation, which might improve the use of adult stem cells in cardiovascular tissue engineering in the future.
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3

Fuchs, Elaine, and Eric Olson. "Cell differentiation." Current Opinion in Cell Biology 8, no. 6 (December 1996): 823–25. http://dx.doi.org/10.1016/s0955-0674(96)80083-4.

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4

Fuchs, Elaine, and Fiona M. Watt. "Cell differentiation." Current Opinion in Cell Biology 15, no. 6 (December 2003): 738–39. http://dx.doi.org/10.1016/j.ceb.2003.10.018.

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Goldstein, Lawrence, and Sean Morrison. "Cell differentiation." Current Opinion in Cell Biology 16, no. 6 (December 2004): 679–80. http://dx.doi.org/10.1016/j.ceb.2004.10.001.

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Brand, Andrea H., and Frederick J. Livesey. "Cell differentiation." Current Opinion in Cell Biology 17, no. 6 (December 2005): 637–38. http://dx.doi.org/10.1016/j.ceb.2005.10.007.

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7

Bronner-Fraser, Marianne. "Cell differentiation." Current Opinion in Cell Biology 18, no. 6 (December 2006): 690–91. http://dx.doi.org/10.1016/j.ceb.2006.10.011.

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8

Farmer, Stephen R., and Bruce M. Spiegelman. "Cell differentiation." Current Opinion in Cell Biology 19, no. 6 (December 2007): 603–4. http://dx.doi.org/10.1016/j.ceb.2007.11.002.

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9

Derynck, Rik, and ErwinF Wagner. "Cell differentiation." Current Opinion in Cell Biology 7, no. 6 (January 1995): 843–44. http://dx.doi.org/10.1016/0955-0674(95)80068-9.

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10

Steel, Michael. "CELL DIFFERENTIATION." Lancet 341, no. 8854 (May 1993): 1187–88. http://dx.doi.org/10.1016/0140-6736(93)91010-j.

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Дисертації з теми "Cell differentiation"

1

Falk, Anna. "Stem cells : proliferation, differentiation, migration /." Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-497-X/.

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2

Brigham, Lindy Andersen 1951. "Root border cell differentiation." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290689.

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The inability of a plant to run from danger or seek nutrients necessitates its capacity to change the environment of the surrounding soil for protection and sustenance. A unique plant process, the release of thousands of autonomous cells from the root cap, called root border cells, may play a role in the ability of the plant to regulate microbial populations and nutrient availability in the rhizosphere. In this study, evidence is presented showing that root border cells are a differentiated tissue, that the production of border cells is highly regulated and tied to cell turnover in the root cap and that products of border cells regulate cell division in the root cap meristem. In vivo labeling experiments demonstrate that 13% of the proteins that are abundant in preparations from border cells are undetectable in root tip cells. Differences between the two cell populations are apparent as soon as border cells separate from each other, even when they are still adhered to the root tip. Twenty-five percent of the proteins synthesized by border cells in a 1-hour period are rapidly excreted into the incubation medium. Border cells arise within the root cap meristem by cell division and their production is tightly regulated both developmentally and in response to border cell removal. Removal of border cells results in the induction of cell division in the transverse root cap meristem to 400% of the basal rate within 30 minutes. This elevated rate of mitosis is maintained for 1.5 h and falls to basal levels within 6 hours. During this time, mitosis in the root apical meristem remains constant. mRNA differential display analysis showed changes in gene expression in the root cap within 5 to 15 minutes of removal of border cells. Genes putatively involved in cell functions in three regions of the cap showed expected distribution patterns by in situ hybridization and RNA blot analysis revealed changes in their expression patterns were seen in response to border cell removal. The presence of border cells acts as an inhibitor to continued mitosis and border cell production in the root cap. Evidence from fractionation studies shows that a heat stable, protease insensitive molecule in the range of 25 to 80 kDa, produced by the border cells themselves, is responsible for this inhibition.
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3

Loop, Franciscus Theodorus Lambertus van der. "Cell biological aspects of muscle cell differentiation." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=7288.

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4

Li, Victor Chun. "The Cell Cycle and Differentiation in Stem Cells." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10536.

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The relationship between cellular proliferation and differentiation is a major topic in cell biology. What we know comes from models of somatic cell differentiation, where it is widely viewed that cycling and differentiation are coupled, antagonistic phenomena linked at the G1 phase. The extension of this view to stem cells, however, is unclear. One potential possibility is that stem cells also tightly link their G1 phase with their differentiation, indicating a similarity between the differentiation of stem cells and the differentiation of more mature somatic cells. On the other hand, stem cells may utilize different mechanisms or adaptations that confer on them some aspect of uniqueness or "stemness." In this case, stem cells will not exhibit the same coupling with the cell cycle as in many somatic cell models. In this thesis, we examined mouse embryonic stem cells (mESCs), a stem cell that is pluripotent and rapidly cycling with a highly condensed G1 phase. Direct extension of the somatic view posits that elongation of their G1 phase to somatic lengths by cyclin-dependent kinase (CDK) activity inhibition should induce or increase differentiation of these stem cells. Evidence supporting this claim has been contradictory. We show that elongation of the cell cycle and elongation of G1 to somatic lengths is fully compatible with the pluripotent state of mESCs. Multiple methods that lengthen the cell cycle and that target CDK activity or that trigger putative downstream mechanisms (i.e. Rb and E2F activity) all fail to induce differentiation on their own or even to facilitate differentiation. These results indicates that the model of linkage between the G1 phase and differentiation in mESCs is incorrect and leads us to propose that "stemness" may have a physiological basis in the decoupling of cell cycling and differentiation. In summary, we provide evidence that there is a resistance of mESCs to differentiation induced by lengthening G1 and/or the cell cycle. This could allow for separate control of these events and provide new opportunities for investigation and application.
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5

Ellison, David William. "Cell proliferation, cell death, and differentiation in gliomas." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295912.

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6

Xue, Yintong. "Glucocorticoid in T cell differentiation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3950-0/.

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7

Locklin, Rachel M. S. "Biochemistry of bone cell differentiation." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363755.

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8

Giddings, Ian. "Analysis of myeloid cell differentiation." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285145.

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9

Jones, Philip Anthony. "B cell differentiation in sheep." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/30327.

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The ileal Peyer's patch (IPP) of lambs is a region of intense lymphopoiesis and B cell development. Monoclonal antibodies against ovine lymphoctye antigens have been used to characterise the IPP lymphocyte. Three murine monoclonal antibodies against ovine IgM, IgG1 and Ig light chain were produced and are described fully. IgM and MHC class II antigens are expressed on the vast majority of IPP cells whilst cells bearing other serum Ig isotypes and T cell antigens are rare. A novel Ig molecule appears to be coexpressed with IgM, it is proposed that this is the ovine equivalent of IgD. IPP cells can be induced to proliferate and differentiate when cultured with lipo-polysaccharide (LPS) and interleukin 2 (IL2). Proliferation is inhibited by rabbit anti-sheep Ig antibodies. Using an ELISA for Ig, it has been possible to quantitate Ig synthesis and secretion. Mean cellular Ig increases greater than 25-fold during differentiation. High-rate secretion begins 4 days after initiation of culture and is virtually complete by day 7. As IPP B cells differentiate to IgM secretion, membrane Ig is rapidly lost so that by day 6, only 15% of cells express Ig on their surfaces. Changes in MHC class II antigens were also studied. Surface expression of MHC class II molecules doubled by 24 hours and slowly declined to resting levels as differentiation proceeded. A large increase in cytoplasmic MHC class II content was noted on day 3. The reasons for this increase are discussed. Kinetic studies suggest that IL2 responsiveness is acquired approximately 20 hours after activation by LPS. The concentration required to give half maximal Ig secretion is 125 pM indicating that the interaction between IL2 and its receptor is one of high affinity. During differentiation, the cells enlarge and show an increase in the cytoplasmic:nuclear ratio. The formation of extensive rough endoplasmic reticulum and additional mitochondria is indicative of the functional changes occurring. This is the first description of a sheep B cell differentiation assay. It is proposed that this system is a suitable model on which to base further studies into the molecular biology of sheep Ig genes, Ig isotype switching and lymphokines and their receptors.
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10

Park, Jaesang. "Automatic white blood cell differentiation /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074435.

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Книги з теми "Cell differentiation"

1

B, Fisher Paul, ed. Mechanisms of differentiation. Boca Raton: CRC Press, 1990.

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2

Lugli, Enrico, ed. T-Cell Differentiation. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6548-9.

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3

Aarbakke, Jarle, Peter K. Chiang, and H. Phillip Koeffler, eds. Tumor Cell Differentiation. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4594-0.

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4

D, Befus, Bienenstock John, Denburg Judah A, and Mast Cell Symposium (1985 : Alton, Ont.), eds. Mast cell differentiation and heterogeneity. New York: Raven Press, 1986.

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5

J, Paige C., and Gisler R. H, eds. Differentiation of B lymphocytes. Berlin: Springer-Verlag, 1987.

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6

B, Ivanova Laura, ed. Cell differentiation research developments. New York: Nova Biomedical Books, 2007.

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7

1941-, Hall Brian Keith, ed. Cell commitment and differentiation. Cambridge [Cambridgeshire]: Cambridge University Press, 1987.

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8

I, Sherman Michael, ed. Retinoids and cell differentiation. Boca Raton, Fla: CRC Press, 1986.

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9

Norman, Maclean. Cell commitment and differentiation. Cambridge: Cambridge University Press, 1987.

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10

B, Ivanova Laura, ed. Cell differentiation research developments. New York: Nova Biomedical Books, 2007.

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Частини книг з теми "Cell differentiation"

1

Singla, Dinender K., Shreeya Jayaraman, Jianhua Zhang, and Timothy J. Kamp. "Cardiomyocyte Differentiation." In Human Cell Culture, 211–34. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-5983-4_12.

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2

Cerdan, Chantal, Veronica Ramos-Mejia, and Mickie Bhatia. "Hematopoietic Differentiation." In Human Cell Culture, 53–83. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-5983-4_5.

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3

Zhang, Zhi-Jian, Jason S. Meyer, and Su-Chun Zhang. "Neural Differentiation." In Human Cell Culture, 85–108. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-5983-4_6.

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4

Sharon, Nadav, and Nissim Benvenisty. "Mesodermal Differentiation." In Human Cell Culture, 129–48. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-5983-4_8.

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5

Smith, C. A., and E. J. Wood. "Differentiation and development." In Cell Biology, 463–94. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0441-8_15.

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6

Sachs, Leo. "Hematopoietic Growth and Differentiation Factors and the Reversal of Malignancy." In Tumor Cell Differentiation, 3–27. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4594-0_1.

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7

Koeffler, H. P., A. Tobler, H. Reichel, and A. Norman. "Interaction of 1,25 Dihydroxyvitamin D3 with Normal and Abnormal Hematopoiesis." In Tumor Cell Differentiation, 137–57. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4594-0_10.

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8

Breitman, Theodore R. "Retinoic Acid-Induced Differentiation of HL-60: Studies in Vitro and in Vivo." In Tumor Cell Differentiation, 159–81. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4594-0_11.

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9

Abita, J. P., A. Ladoux, B. Geny, A. Faille, O. Poirier, and I. Krawice. "Plasma Membrane Signals Linked to the Retinoic Acid-Induced Differentiation of HL-60 Cells." In Tumor Cell Differentiation, 183–94. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4594-0_12.

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10

Lie, Sverre O. "Does Induction of Differentiation Have a Role in the Maintenance of Remission in Acute Myelogenous Leukemia in Children?" In Tumor Cell Differentiation, 195–203. Totowa, NJ: Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4594-0_13.

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Тези доповідей конференцій з теми "Cell differentiation"

1

Rajendiran, Shenbageshwaran, Francisco Galdos, Carissa Anne Lee, Sidra Xu, Justin Harvell, Shireen Singh, Sean M. Wu, Elizabeth A. Lipke, and Selen Cremaschi. "Modeling hiPSC-to-Early Cardiomyocyte Differentiation Process using Microsimulation and Markov Chain Models." In Foundations of Computer-Aided Process Design, 344–50. Hamilton, Canada: PSE Press, 2024. http://dx.doi.org/10.69997/sct.152564.

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Cardiomyocytes (CMs), the contractile heart cells that can be derived from human induced pluripotent stem cells (hiPSCs). These hiPSC derived CMs can be used for cardiovascular disease drug testing and regeneration therapies, and they have therapeutic potential. Currently, hiPSC-CM differentiation cannot yet be controlled to yield specific heart cell subtypes consistently. Designing differentiation processes to consistently direct differentiation to specific heart cells is important to realize the full therapeutic potential of hiPSC-CMs. A model that accurately represents the dynamic changes in cell populations from hiPSCs to CMs over the differentiation timeline is a first step towards designing processes for directing differentiation. This paper introduces a microsimulation model for studying temporal changes in the hiPSC-to-early CM differentiation. The differentiation process for each cell in the microsimulation model is represented by a Markov chain model (MCM). The MCM includes cell subtypes representing key developmental stages in hiPSC differentiation to early CMs. These stages include pluripotent stem cells, early primitive streak, late primitive streak, mesodermal progenitors, early cardiac progenitors, late cardiac progenitors, and early CMs. The time taken by a cell to transit from one state to the next state is assumed to be exponentially distributed. The transition probabilities of the Markov chain process and the mean duration parameter of the exponential distribution were estimated using Bayesian optimization. The results predicted by the MCM agree with the data.
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2

Sargent, Carolyn Y., Luke A. Hiatt, Sandhya Anantharaman, Eric Berson, and Todd C. McDevitt. "Cardiogenesis of Embryonic Stem Cells is Modulated by Hydrodynamic Mixing Conditions." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193129.

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Embryonic stem cells (ESCs) have the potential to differentiate into all somatic cell types and are uniquely capable of differentiating into functional cardiomyocytes; however, to effectively use ESCs for cell-based therapies to regenerate viable myocardial tissue, an improved understanding of mechanisms regulating differentiation is necessary. Currently, application of exogenous factors is commonly attempted to direct stem cell differentiation; however, progression towards controlling multiple environmental factors, including biochemical and mechanical stimuli, may result in increased differentiation efficiency for clinical applications. Additionally, current methods of ESC differentiation to cardiomyocytes are labor-intensive and produce relatively few cardiomyocytes based on initial ESC densities. Rotary suspension culture to produce embryoid bodies (EBs) has been shown to yield greater numbers of differentiating ESCs than static suspension cultures [1]. Thus, the objective of this study was to examine how the hydrodynamic mixing conditions imposed by rotary orbital culture modulate cardiomyocyte differentiation.
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3

Li, Lulu, Rene Schloss, Noshir Langrana, and Martin Yarmush. "Effects of Encapsulation Microenvironment on Embryonic Stem Cell Differentiation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192587.

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Pluripotent embryonic stem cells represent a promising renewable cell source to generate a variety of differentiated cell types. Although many investigators have described techniques to effectively differentiate stem cells into different mature cell lineages, their practicality is limited by the absence of large scale processing consideration and low yields of differentiated cells. Previously we have established a murine embryonic stem cell alginate-poly-l-lysine microencapsulation differentiation system. The three-dimensional alginate microenvironment maintains cell viability, is conducive to ES cell differentiation to hepatocyte lineage cells, and maintains differentiated cellular function. In the present work, we demonstrate that hepatocyte differentiation is mediated by cell-cell aggregation in the encapsulation microenvironment. Both cell aggregation and hepatocyte functions, such as urea and albumin secretion, as well as increased expression of cytokaratin 18 and cyp4507a, occur concomitantly with surface E-cadherin expression. Furthermore, by incorporating soluble inducers, such as retinoic acid, into the permeable microcapsule system, we demonstrate decreased cell aggregation and enhanced neuronal lineage differentiation with the expression of various neuronal specific markers, including neurofilament, A2B5, O1 and GFAP. Therefore, as a result of capsule parameter and microenvironment manipulation, we are capable of targeting cellular differentiation to both endodermal and ectodermal cell lineages.
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4

Paul, Amit, David Franz, Sumaira Yahya, Shan Sun, and Michael Cho. "Predictive Modeling and Biomechanical Microengineering of Mesenchymal Stem Cells: A High Content Screening Platform to Enhance Lineage Specific Differentiation." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14639.

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Recent evidence suggests that stem cell differentiation can be regulated by modulation of the cell’s biomechanics. The cytoskeletal structures and arrangements in stem cells undergoing differentiation are dramatically altered, and these alterations vary by lineage. The complexity of events associated with the transformation of these precursor cells leaves many questions unanswered about morphological, structural, proteomic, and functional changes in differentiating stem cells. A thorough understanding of stem cell behavior, both experimentally and computationally, would allow for the development of more effective approaches to the expansion of stem cells in vitro and for the regulation of their commitment to a specific phenotype.
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Niu, Naiqian, Karin Provost, Robert Homer, and Lauren E. Cohn. "IFN-? Inhibits Goblet Cell Differentiation." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2052.

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6

Monteiro, Gary A., and David I. Shreiber. "Guiding Stem Cell Differentiation Into Neural Lineages With Tunable Collagen Biomaterials." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206752.

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The long-term objective of this research is to develop tunable collagen-based biomaterial scaffolds for directed stem cell differentiation into neural lineages to aid in CNS diseases and trauma. Type I collagen is a ubiquitous protein that provides mechanostructural and ligand-induced biochemical cues to cells that attach to the protein via integrin receptors. Previous studies have demonstrated that the mechanical properties of a substrate or tissue can be an important regulator of stem cell differentiation. For example, the mechanical properties polyacrylamide gels can be tuned to induce neural differentiation from stem cells [1, 2]. Mesenchymal stem cells (MSCs) cultured on ployacrylamide gels with low elastic modulus (0.1–1 kPa) resulted in a neural like population. MSCs on 10-fold stiffer matrices that mimic striated muscle elasticity (Emuscle ∼8–17 kPa) lead to spindle-shaped cells similar in shape to myoblasts. Still stiffer gels (25–40 kPa) resulted in osetoblast differentiation. Based on these observations, collagen gels may provide an ideal material for differentiation into neural lineages because of their low compliance.
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7

Leahy, Rachel, Weiling Xu, Suzy A. A. Comhair, and Serpil C. Erzurum. "Hypoxia In Airway Epithelial Cell Differentiation." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5115.

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8

Li, Lulu, Alexander Davidovich, Jennifer Schloss, Uday Chippada, Rene Schloss, Noshir Langrana, and Martin Yarmush. "Control of Neural Lineage Differentiation in an Alginate Encapsulation Microenvironment via Cellular Aggregation." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206496.

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Cell replacement therapies, which utilize renewable stem cell sources, hold tremendous potential to treat a wide range of degenerative diseases. Although many studies have established techniques to successfully differentiate stem cells into different mature cell lineages, their practicality is limited by the lack of control during the differentiation process and low yields of differentiated cells. In order to address these issues, we have previously established a murine embryonic stem cell alginate-poly-L-lysine microencapsulation differentiation system [1]. We demonstrated that ES cell differentiation could be mediated by cell-cell aggregation in the encapsulation microenvironment. We have demonstrated that both cell aggregation and hepatocyte functions, such as urea and albumin secretions, as well as increased expression of cytokeratin 18 and cyp4507a, occur concomitantly with surface E-cadherin expression [2]. In the present studies, we assessed the feasibility of inducing neuronal lineage differentiation in the alginate microenvironment by incorporating soluble inducers, such as retinoic acid, into the permeable microcapsule system. We demonstrated decreased cell aggregation and enhanced neuronal lineage differentiation with the expression of various neuronal specific markers, including neurofilament, A2B5, O1 and glial fibrillary acidic protein (GFAP). In addition, we demonstrated that, by blocking the cell aggregation using anti-E-cadherin antibody, encapsulated cells increased neuronal marker expression at a later stage of the encapsulation, even in the absence of retinoic acid. In conjunction with the mechanical and physical characterizations of the alginate crosslinking network, we show that 2.2% alginate concentration is most conducive to neuronal differentiation from embryonic stem cells in the presence of retinoic acid.
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9

Pavillon, N., and N. I. Smith. "T cell activation and differentiation monitored non-invasively with Raman spectroscopy." In Conference on Lasers and Electro-Optics/Pacific Rim. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleopr.2022.ctha15e_01.

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We show how Raman spectroscopy can be used to non-invasively monitor the changes occurring at single-cell level during the differentiation of naive T cells into effector cells following activation through in vitro stimulation.
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Maynard, Jacqueline A., Ahmad S. Arabiyat, Anna Elefante, Lucas Shearer, Eoin King, and Andrea Kwaczala. "Using Acoustic Waves to Modulate Stem Cell Growth and Differentiation." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-71341.

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During spaceflight, the loss of mechanical loads due to microgravity leads to rapid bone loss, where bone deteriorates at a rate of 1–2% per month, where some astronauts can lose as much as 20% of their skeletal mass in a single expedition [NASA, 2001]. In order to prevent muscle and bone loss, long-term space flight exercise regimes are strictly implemented [Shackleford, 2004]. Current research has demonstrated that mechanical vibrations can help to maintain or improve bone mass [Chan, 2013] and reduce adiposity [Chen, 2015, Sen, 2011] when signals are applied at the appropriate frequency and amplitude. We have developed an acoustic sound chamber that can apply sound waves to stem cells grown in vitro. Characterization of the culture conditions inside the vibration chamber showed considerable variance across the culture plates where an applied acceleration of 0.6g varied at different spots in a 12-well tissue culture plate from as low as 0.47g to 0.78g. We believe the variance is caused by differences in the rigidity of the culture plates that makes the waves transmit inconsistently through the plastic. We hypothesized acoustic waves would induce osteogenic differentiation when applied to stem cells. We utilized pre-osteoblastic stem cells (MC3T3-E1-Subclone 4) to observe the effects of acoustic waves when applied at 0.3g and 0.6g, compared to non-vibrated controls. Cells were vibrated for 30 minutes a day for either 6 days (n = 24/group) or 12 days (n = 12/group). Cellular changes were characterized by assessing well-by-well cell number by a manual cell count and mineral content by Alizarin Red S staining. Differences between groups were determined using One-Way ANOVA with a post hoc test: Student’s t-test. To assess the effects of the variance across the culture plates, correlative analysis was conducted for well-by-well variation using Regression Analysis. Acoustically vibrated wells had 10x more cells after 6 days and showed more mineralization than non-vibrated wells at both 6 and 12 days. Acoustic waves have the ability to increase cell proliferation and can drive stem cell differentiation towards an osteoblastic lineage, this could lead to therapies that prevent bone loss during spaceflight.
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Звіти організацій з теми "Cell differentiation"

1

Ma, Hong. Analysis of Anther Cell Differentiation. Office of Scientific and Technical Information (OSTI), January 2015. http://dx.doi.org/10.2172/1167414.

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2

Dooner, Mark, Jason M. Aliotta, Jeffrey Pimental, Gerri J. Dooner, Mehrdad Abedi, Gerald Colvin, Qin Liu, Heinz-Ulli Weier, Mark S. Dooner, and Peter J. Quesenberry. Cell Cycle Related Differentiation of Bone Marrow Cells into Lung Cells. Office of Scientific and Technical Information (OSTI), December 2007. http://dx.doi.org/10.2172/936517.

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3

Du, Liqin, Zhenze Zhao, Alexander Pertsemlidis, and Xiuye Ma. Identifying microRNAs that Regulate Neuroblastoma Cell Differentiation. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada611996.

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4

Thomas, Sheila M. Role of Cortactin in Cell Growth and Differentiation. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada403401.

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5

Thomas, Shelia M. Role of Cortactin in Cell Growth and Differentiation. Fort Belvoir, VA: Defense Technical Information Center, September 2002. http://dx.doi.org/10.21236/ada411519.

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6

Jones, Erin Boote. Effects of Substrate and Co-Culture on Neural Progenitor Cell Differentiation. Office of Scientific and Technical Information (OSTI), January 2008. http://dx.doi.org/10.2172/939376.

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7

D'Andrea, Annalisa. Inhibition of Th17 Cell Differentiation as a Treatment for Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada577274.

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8

D Andrea, Annalisa. Inhibition of Th17 Cell Differentiation as a Treatment for Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada589923.

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9

Vaught, David B. Neuregulin Driven Cell Differentiation, Transformation, and Parity of Luminal Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, December 2013. http://dx.doi.org/10.21236/ada598353.

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10

King, Ritcher C. Regulation of Breast Cancer Cell Repression and Differentiation by ErbB2 Ligand. Fort Belvoir, VA: Defense Technical Information Center, March 1998. http://dx.doi.org/10.21236/adb236753.

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