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Статті в журналах з теми "CDM registry"
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Kearsley-Fleet, L., K. Hyrich, M. Schaefer, D. Huschek, A. Strangfeld, J. Zavada, M. Lagová, et al. "OP0105 FEASIBILITY AND USEFULNESS OF MAPPING BIOLOGIC REGISTRIES TO A COMMON DATA MODEL: ILLUSTRATION USING COMORBIDITIES." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 58.2–59. http://dx.doi.org/10.1136/annrheumdis-2021-eular.888.
Повний текст джерелаАнотація:
Background:The Observational and Medical Outcomes Partnerships (OMOP) common data model (CDM) provides a framework for standardising health data with a view towards federated analyses, thus maximising the use and power of combining disparate datasets.Objectives:To assess feasibility and usefulness of mapping biologic registry data from different European countries to the OMOP CDM and present initial descriptive data regarding comorbidities.Methods:Five biologic registries, as part of a funded FOREUM project, have been mapped to the OMOP CDM: 1) the Czech biologics register (ATTRA), 2) Registro Español de Acontecimientos Adversos de Terapias Biológicas en Enfermedades Reumáticas (BIOBADASER), 3) British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA), 4) German biologics register ‘Rheumatoid arthritis observation of biologic therapy’ (RABBIT), and 5) Swiss register ‘Swiss Clinical Quality Management in Rheumatic Diseases’ (SCQM). The mapping includes socio-demographic, observation period within the studies, baseline comorbidities, and baseline medications. Only patients with RA were included. Using R, registers received identical scripts to run on their mapped databases to produce an initial description of patient characteristics without the need to share patient-level data.Results:A total of 54,458 individuals are included the five registries being mapped to the OMOP CDM, see table. Age and gender distribution was similar across registries. All registers reported on cardiovascular system comorbidities, diabetes mellitus, mental disorders, and respiratory system comorbidities. However, it was noted that results of comorbidity mapping relies on what each register collect on each patient at the point of registration.Whilst the Charlson comorbidity index could be calculated within each registry, due to lack of the specific coding needed, such as “uncomplicated diabetes mellitus” / “end-organ damage diabetes mellitus”, it was felt to be an inaccurate measure. The granularity of the comorbidities was insufficient, as many registers coded, for example, diabetes mellitus without any extra information.Table 1.OARSI scoresRegistryATTRABIOBADASERBSRBR-RARABBITSCQMCountryCzechiaSpainUnited KingdomGermanySwitzerlandNumber of Participants23343012251791365210281Gender FemaleMale1808 (77%)526 (23%)2372 (79%)640 (21%)18995 (75%)6184 (25%)10191 (75%)3461 (25%)7584 (74%)2697 (26%)Age at observation start date59 (52, 66)56 (47, 63)58 (49, 66)58 (50, 67)57 (47, 66)First observation start dateFeb-2002Oct-1999Oct-2001Aug-2006March-1995Number of comorbidities1 (1, 2)1 (0, 2)1 (0, 2)2 (1, 3)2 (1, 4)Disorder of cardiovascular system1609 (69%)208 (7%)2239 (9%)6330 (46%)3969 (39%)Diabetes mellitus331 (14%)273 (9%)1770 (7%)1591 (12%)792 (8%)Depressive Disorder165 (7%)04971 (20%)1023 (7%)1337 (13%)Disorder of respiratory system215 (9%)209 (7%)4125 (16%)1282 (9%)1630 (16%)Conclusion:This is the first analysis of data from the newly mapped OMOP CDM across five European registers. Through mapping the registers into a CDM, and using the same script, the ability to undertake collaborative analysis without sharing patient level data outside of the country can be realised. Due to differences in study design and data capture, there needs to be a focus on harmonising the coding and analysing of the comorbidities and drugs across registries.Disclosure of Interests:Lianne Kearsley-Fleet: None declared, Kimme Hyrich: None declared, Martin Schaefer: None declared, Doreen Huschek: None declared, Anja Strangfeld: None declared, Jakub Zavada Speakers bureau: Abbvie, Eli-Lilly, UCB, Sanofi., Consultant of: Abbvie, UCB, Sanofi, Gilead., Markéta Lagová: None declared, Delphine Courvoisier Speakers bureau: Medtalks Switzerland, Christoph Tellenbach: None declared, Kim Lauper Speakers bureau: Medtalks Switzerland, Carlos Sánchez-Piedra: None declared, Nuria Montero: None declared, Jesús-Tomás Sánchez-Costa: None declared, Daniel Prieto-Alhambra Consultant of: Amgen (speaker fees and advisory board membership fees paid to DPA’s department) and UCB (consultancy fees paid to DPA’s department), Grant/research support from: grants and other from AMGEN, grants, non-financial support and other from UCB Biopharma, grants from Les Laboratoires Servier, outside the submitted work., Edward Burn: None declared
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Burn, E., L. Kearsley-Fleet, K. Hyrich, M. Schaefer, D. Huschek, A. Strangfeld, J. Zavada, et al. "OP0285 TOWARDS IMPLEMENTING THE OMOP CDM ACROSS FIVE EUROPEAN BIOLOGIC REGISTRIES." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 177.2–178. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3303.
Повний текст джерелаАнотація:
Background:The Observational and Medical Outcomes Partnerships (OMOP) common data model (CDM) provides a framework for standardising health data.Objectives:To map national biologic registry data collected from different European countries to the OMOP CDM.Methods:Five biologic registries are currently being mapped to the OMOP CDM: 1) the Czech biologics register (ATTRA), 2) Registro Español de Acontecimientos Adversos de Terapias Biológicas en Enfermedades Reumáticas (BIOBADASER), 3) British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA), 4) German biologics register ‘Rheumatoid arthritis observation of biologic therapy’ (RABBIT), and 5) Swiss register ’Swiss Clinical Quality Management in Rheumatic Diseases’ (SCQM).Data collected at baseline are being mapped first. Details that uniquely identify individuals are mapped to the person table, with the observation_period table defining the time a person may have had clinical events recorded. Baseline comorbidities are mapped to the condition_occurrence CDM table, while baseline medications are mapped to the drug_exposure CDM table. This mapping is summarised in Figure 1.Figure 1.Overview of initial mappingResults:A total of 64,901 individuals are included in the 5 registries being mapped to the OMOP CDM, see table 1. The number of unique baseline conditions being mapped range from 17 in BSRBR-RA to 108 in RABBIT, while the number of baseline medications range from 26 in ATTRA to 802 in BSRBR-RA. Those registries which captured more comorbidities or medications generally allowed for these to be inputted as free text.Table 1.Summary of initial code mappingRegistryNumber of individualsNumber of mapped baseline conditionsNumber of mapped baseline medicationsATTRA5,3262626BIOBADASER6,4963051BSRBR-RA21,69517802RABBIT13,06210878SCQM18,3222633Conclusion:Due to differences in study design and data capture, the baseline information captured on comorbidities and drugs across registries varies greatly. However, these data have been mapped and mapping biologic registry data to the OMOP CDM is feasible. The adoption of the OMOP CDM will facilitate collaboration across registries and allow for multi-database studies which include data from both biologic registries and other sources of health data which have been mapped to the CDM.Disclosure of Interests:Edward Burn: None declared, Lianne Kearsley-Fleet: None declared, Kimme Hyrich Grant/research support from: Pfizer, UCB, BMS, Speakers bureau: Abbvie, Martin Schaefer: None declared, Doreen Huschek: None declared, Anja Strangfeld Speakers bureau: AbbVie, BMS, Pfizer, Roche, Sanofi-Aventis, Jakub Zavada Speakers bureau: Abbvie, UCB, Sanofi, Elli-Lilly, Novartis, Zentiva, Accord, Markéta Lagová: None declared, Delphine Courvoisier: None declared, Christoph Tellenbach: None declared, Kim Lauper: None declared, Carlos Sánchez-Piedra: None declared, Nuria Montero: None declared, Jesús-Tomás Sanchez-Costa: None declared, Daniel Prieto-Alhambra Grant/research support from: Professor Prieto-Alhambra has received research Grants from AMGEN, UCB Biopharma and Les Laboratoires Servier, Consultant of: DPA’s department has received fees for consultancy services from UCB Biopharma, Speakers bureau: DPA’s department has received fees for speaker and advisory board membership services from Amgen
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Bardenheuer, Kristina, Alun Passey, Maria d'Errico, Barbara Millier, Carine Guinard-Azadian, Johan Aschan, and Michel van Speybroeck. "Honeur (Heamatology Outcomes Network in Europe): A Federated Model to Support Real World Data Research in Hematology." Blood 132, Supplement 1 (November 29, 2018): 4839. http://dx.doi.org/10.1182/blood-2018-99-111093.
Повний текст джерелаАнотація:
Abstract Introduction: The Haematology Outcomes Network in EURope (HONEUR) is an interdisciplinary initiative aimed at improving patient outcomes by analyzing real world data across hematological centers in Europe. Its overarching goal is to create a secure network which facilitates the development of a collaborative research community and allows access to big data tools for analysis of the data. The central paradigm in the HONEUR network is a federated model whereby the data stays at the respective sites and the analysis is executed at the local data sources. To allow for a uniform data analysis, the common data model 'OMOP' (Observational Medical Outcomes Partnership) was selected and extended to accommodate specific hematology data elements. Objective: To demonstrate feasibility of the OMOP common data model for the HONEUR network. Methods: In order to validate the architecture of the HONEUR network and the applicability of the OMOP common data model, data from the EMMOS registry (NCT01241396) have been used. This registry is a prospective, non-interventional study that was designed to capture real world data regarding treatments and outcomes for multiple myeloma at different stages of the disease. Data was collected between Oct 2010 and Nov 2014 on more than 2,400 patients across 266 sites in 22 countries. Data was mapped to the OMOP common data model version 5.3. Additional new concepts to the standard OMOP were provided to preserve the semantic mapping quality and reduce the potential loss of granularity. Following the mapping process, a quality analysis was performed to assess the completeness and accuracy of the mapping to the common data model. Specific critical concepts in multiple myeloma needed to be represented in OMOP. This applies in particular for concepts like treatment lines, cytogenetic observations, disease progression, risk scales (in particular ISS and R-ISS). To accommodate these concepts, existing OMOP structures were used with the definition of new concepts and concept-relationships. Results: Several elements of mapping data from the EMMOS registry to the OMOP common data model (CDM) were evaluated via integrity checks. Core entities from the OMOP CDM were reconciled against the source data. This was applied for the following entities: person (profile of year of birth and gender), drug exposure (profile of number of drug exposures per drug, at ATC code level), conditions (profile of number of occurrences of conditions per condition code, converted to SNOMED), measurement (profile of number of measurements and value distribution per (lab) measurement, converted to LOINC) and observation (profile of number of observations per observation concept). Figure 1 shows the histogram of year of birth distribution between the EMMOS registry and the OMOP CDM. No discernible differences exist, except for subjects which have not been included in the mapping to the OMOP CDM due to lacking confirmation of a diagnosis of multiple myeloma. As additional part of the architecture validation, the occurrence of the top 20 medications in the EMMOS registry and the OMOP CDM were compared, with a 100% concordance for the drug codes, which is shown in Figure 2. In addition to the reconciliation against the different OMOP entities, a comparison was also made against 'derived' data, in particular 'time to event' analysis. Overall survival was plotted from calculated variables in the analysis level data from the EMMOS registry and derived variables in the OMOP CDM. Probability of overall survival over time was virtually identical with only one day difference in median survival and 95% confidence intervals identically overlapping over the period of measurement (Figure 3). Conclusions: The concordance of year of birth, drug code mapping and overall survival between the EMMOS registry and the OMOP common data model indicates the reliability of mapping potential in HONEUR, especially where auxiliary methods have been developed to handle outcomes and treatment data in a way that can be harmonized across platform datasets. Disclosures No relevant conflicts of interest to declare.
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Carus, Jasmin, Sylvia Nürnberg, Frank Ückert, Catarina Schlüter, and Stefan Bartels. "Mapping Cancer Registry Data to the Episode Domain of the Observational Medical Outcomes Partnership Model (OMOP)." Applied Sciences 12, no. 8 (April 15, 2022): 4010. http://dx.doi.org/10.3390/app12084010.
Повний текст джерелаАнотація:
A great challenge in the use of standardized cancer registry data is deriving reliable, evidence-based results from large amounts of data. A solution could be its mapping to a common data model such as OMOP, which represents knowledge in a unified semantic base, enabling decentralized analysis. The recently released Episode Domain of the OMOP CDM allows episodic modelling of a patient’ disease and treatment phases. In this study, we mapped oncology registry data to the Episode Domain. A total of 184,718 Episodes could be implemented, with the Concept of Cancer Drug Treatment most frequently. Additionally, source data were mapped to new terminologies as part of the release. It was possible to map ≈ 73.8% of the source data to the respective OMOP standard. Best mapping was achieved in the Procedure Domain with 98.7%. To evaluate the implementation, the survival probabilities of the CDM and source system were calculated (n = 2756/2902, median OAS = 82.2/91.1 months, 95% Cl = 77.4–89.5/84.4–100.9). In conclusion, the new release of the CDM increased its applicability, especially in observational cancer research. Regarding the mapping, a higher score could be achieved if terminologies which are frequently used in Europe are included in the Standardized Vocabulary Metadata Repository.
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van Bragt, Job J. M. H., Susanne Hansen, Ratko Djukanovic, Elisabeth H. D. Bel, Anneke ten Brinke, Scott S. Wagers, Anke H. Maitland-van der Zee, and Celeste Porsbjerg. "SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma." ERJ Open Research 7, no. 2 (March 18, 2021): 00064–2021. http://dx.doi.org/10.1183/23120541.00064-2021.
Повний текст джерелаАнотація:
Real-world evidence is important to help unravel unanswered problems in severe asthma and is valuable to better understand the patient experience and common clinical practice.The Severe Heterogeneous Asthma Registry, Patient-centred (SHARP) Clinical Research Collaboration is created as a network of national registries and severe asthma centres that work together to perform registry based real-world research and clinical studies on a pan-European scale.Such collaboration requires a new, innovative design to overcome the many issues that arise with large-scale data collection across national borders. SHARP has developed a platform that offers a federated analysis approach where national registry data are transformed and integrated into a common data model (CDM). The CDM then allows a local analysis of de-identified patient data and subsequent aggregate (meta-)analysis. To facilitate an easily accessible way to set up new registries, SHARP enables new registries to take part in a central database, based on already proven technology. Next to being economical, this linkage ensures data from different SHARP central members to be comparable.Technological advancements lead to an ever-expanding rate of patient data that will be collected; with the collective effort of the pan-European severe asthma research community SHARP hopes to ensure that they are well equipped to enter a new era of medical research, with the ultimate goal to positively impact the lives of patients with severe asthma.
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Welberry, Heidi, Margo Linn Barr, Elizabeth J. Comino, Ben F. Harris-Roxas, Elizabeth Harris, and Mark Fort Harris. "Increasing use of general practice management and team care arrangements over time in New South Wales, Australia." Australian Journal of Primary Health 25, no. 2 (2019): 168. http://dx.doi.org/10.1071/py18113.
Повний текст джерелаАнотація:
The number of older people living with chronic health conditions is increasing in Australia. The Chronic Disease Management (CDM) items program was introduced to the Medicare Benefits Schedule (MBS) to encourage a more structured approach to managing patients with chronic conditions. Initial uptake was slow and recent research has suggested that uptake is decreasing. This paper examines: person MBS CDM claims in NSW between 2006 and 2014 — using baseline survey data (2006–09) from the Sax Institute’s 45 and Up Study linked to MBS and Death Registry data (2006–14) — and MBS CDM claims per 100000 population — using billing data sourced from the Medicare Australia Statistics website — to systematically examine any changes in uptake using a time-series analysis. After age adjustment, claims for initial plans increased from 11.3% in 2006 to 22.4% in 2014. Increases were also seen for allied health service claims (from 4.1% in 2006 to 20.8% in 2014) and for plan reviews (from 5.9% in 2006 to 16.0% in 2014). These increases were consistent with the MBS summary claims data. There is evidence that these plans are appropriately targeting those in most need; however, there is limited evidence of their effect. Claims for plan reviews, although increasing, are suboptimal and may indicate poor continuity of care.
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Glicksberg, Benjamin Scott, Shohei Burns, Rob Currie, Ann Griffin, Zhen Jane Wang, David Haussler, Theodore Goldstein, and Eric Collisson. "Blockchain-Authenticated Sharing of Genomic and Clinical Outcomes Data of Patients With Cancer: A Prospective Cohort Study." Journal of Medical Internet Research 22, no. 3 (March 20, 2020): e16810. http://dx.doi.org/10.2196/16810.
Повний текст джерелаАнотація:
Background Efficiently sharing health data produced during standard care could dramatically accelerate progress in cancer treatments, but various barriers make this difficult. Not sharing these data to ensure patient privacy is at the cost of little to no learning from real-world data produced during cancer care. Furthermore, recent research has demonstrated a willingness of patients with cancer to share their treatment experiences to fuel research, despite potential risks to privacy. Objective The objective of this study was to design, pilot, and release a decentralized, scalable, efficient, economical, and secure strategy for the dissemination of deidentified clinical and genomic data with a focus on late-stage cancer. Methods We created and piloted a blockchain-authenticated system to enable secure sharing of deidentified patient data derived from standard of care imaging, genomic testing, and electronic health records (EHRs), called the Cancer Gene Trust (CGT). We prospectively consented and collected data for a pilot cohort (N=18), which we uploaded to the CGT. EHR data were extracted from both a hospital cancer registry and a common data model (CDM) format to identify optimal data extraction and dissemination practices. Specifically, we scored and compared the level of completeness between two EHR data extraction formats against the gold standard source documentation for patients with available data (n=17). Results Although the total completeness scores were greater for the registry reports than those for the CDM, this difference was not statistically significant. We did find that some specific data fields, such as histology site, were better captured using the registry reports, which can be used to improve the continually adapting CDM. In terms of the overall pilot study, we found that CGT enables rapid integration of real-world data of patients with cancer in a more clinically useful time frame. We also developed an open-source Web application to allow users to seamlessly search, browse, explore, and download CGT data. Conclusions Our pilot demonstrates the willingness of patients with cancer to participate in data sharing and how blockchain-enabled structures can maintain relationships between individual data elements while preserving patient privacy, empowering findings by third-party researchers and clinicians. We demonstrate the feasibility of CGT as a framework to share health data trapped in silos to further cancer research. Further studies to optimize data representation, stream, and integrity are required.
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Cho, Sylvia, Margaret Sin, Demetra Tsapepas, Leigh-Anne Dale, Syed A. Husain, Sumit Mohan, and Karthik Natarajan. "Content Coverage Evaluation of the OMOP Vocabulary on the Transplant Domain Focusing on Concepts Relevant for Kidney Transplant Outcomes Analysis." Applied Clinical Informatics 11, no. 04 (August 2020): 650–58. http://dx.doi.org/10.1055/s-0040-1716528.
Повний текст джерелаАнотація:
Abstract Background Improving outcomes of transplant recipients within and across transplant centers is important with the increasing number of organ transplantations being performed. The current practice is to analyze the outcomes based on patient level data submitted to the United Network for Organ Sharing (UNOS). Augmenting the UNOS data with other sources such as the electronic health record will enrich the outcomes analysis, for which a common data model (CDM) can be a helpful tool for transforming heterogeneous source data into a uniform format. Objectives In this study, we evaluated the feasibility of representing concepts from the UNOS transplant registry forms with the Observational Medical Outcomes Partnership (OMOP) CDM vocabulary to understand the content coverage of OMOP vocabulary on transplant-specific concepts. Methods Two annotators manually mapped a total of 3,571 unique concepts extracted from the UNOS registry forms to concepts in the OMOP vocabulary. Concept mappings were evaluated by (1) examining the agreement among the initial two annotators and (2) investigating the number of UNOS concepts not mapped to a concept in the OMOP vocabulary and then classifying them. A subset of mappings was validated by clinicians. Results There was a substantial agreement between annotators with a kappa score of 0.71. We found that 55.5% of UNOS concepts could not be represented with OMOP standard concepts. The majority of unmapped UNOS concepts were categorized into transplant, measurement, condition, and procedure concepts. Conclusion We identified categories of unmapped concepts and found that some transplant-specific concepts do not exist in the OMOP vocabulary. We suggest that adding these missing concepts to OMOP would facilitate further research in the transplant domain.
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Morris, Joan K., Ester Garne, Maria Loane, Ingeborg Barisic, James Densem, Anna Latos-Bieleńska, Amanda Neville, et al. "EUROlinkCAT protocol for a European population-based data linkage study investigating the survival, morbidity and education of children with congenital anomalies." BMJ Open 11, no. 6 (June 2021): e047859. http://dx.doi.org/10.1136/bmjopen-2020-047859.
Повний текст джерелаАнотація:
IntroductionCongenital anomalies (CAs) are a major cause of infant mortality, childhood morbidity and long-term disability. Over 130 000 children born in Europe every year will have a CA. This paper describes the EUROlinkCAT study, which is investigating the health and educational outcomes of children with CAs for the first 10 years of their lives.Methods and analysisEUROCAT is a European network of population-based registries for the epidemiological surveillance of CAs. EUROlinkCAT is using the EUROCAT infrastructure to support 22 EUROCAT registries in 14 countries to link their data on births with CAs to mortality, hospital discharge, prescription and educational databases. Once linked, each registry transforms their case data into a common data model (CDM) format and they are then supplied with common STATA syntax scripts to analyse their data. The resulting aggregate tables and analysis results are submitted to a central results repository (CRR) and meta-analyses are performed to summarise the results across all registries. The CRR currently contains data on 155 594 children with a CA followed up to age 10 from a population of 6 million births from 1995 to 2014.EthicsThe CA registries have the required ethics permissions for routine surveillance and transmission of anonymised data to the EUROCAT central database. Each registry is responsible for applying for and obtaining additional ethics and other permissions required for their participation in EUROlinkCAT.DisseminationThe CDM and associated documentation, including linkage and standardisation procedures, will be available post-EUROlinkCAT thus facilitating future local, national and European-level analyses to improve healthcare. Recommendations to improve the accuracy of routinely collected data will be made.Findings will provide evidence to inform parents, health professionals, public health authorities and national treatment guidelines to optimise diagnosis, prevention and treatment for these children with a view to reducing health inequalities in Europe.
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Castellanos Ruiz, Mª José. "Comentarios a las resoluciones de la Dirección General de los Registros y del Notariado de 20 de diciembre de 2016, sobre la inscripción en el Registro de Bienes Muebles de Madrid de varios contratos de arrendamiento financiero sobre aeronaves = Comments to the “resoluciones” of the Dirección General de los Registros y del Notariado of december 20, 2016 on the access to the Chattels Registry in Madrid of several leasing contracts for aircrafts." CUADERNOS DE DERECHO TRANSNACIONAL 9, no. 2 (October 5, 2017): 650. http://dx.doi.org/10.20318/cdt.2017.3894.
Повний текст джерелаАнотація:
Resumen: Las Resoluciones de la DGRN de 20 diciembre 2016, abordan la cuestión del acceso de tres contratos de arrendamiento financiero de aeronaves al Registro de Bienes Muebles. La DGRN examina toda la normativa aplicable al Registro de Bienes Muebles, especialmente el Real Decreto384/2015, de 22 de mayo, por el que se aprueba el Reglamento de matriculación de aeronaves civiles, pues uno de sus objetivos es la coordinación entre el Registro de Bienes Muebles y el Registro de Matrícula de Aeronaves Civiles. Sin embargo, este Real Decreto no soluciona totalmente los problemas que ya existían, con respecto a la inscripción en el Registro de Bienes Muebles de los contratos de arrendamiento financiero sobre aeronaves, pues siguen siendo de aplicación Leyes obsoletas, como es el caso del art. 180 del Reglamento del Registro Mercantil de 1956.Palabras clave: contratos de arrendamiento financiero, aeronaves civiles, Registro de Bienes Muebles, Registro de Matrícula de Aeronaves Civiles, Real Decreto 384/2015, Reglamento del Registro Mercantil de 1956.Abstract: The “Resoluciones” of the Dirección General de los Registros y del Notariado of December 20, 2016 faces the question of the access to the Chattels Registry of three leasing contracts. The Spanish DGRN examines all the regulations applicable to the Chattels Registry, especially Spanish “Real Decreto 384/2015”, of 22 May, which approves the Regulation of registration of civil aircraft, as one of its objectives is coordination between the Chattels Registry y the Aircraft Registry. However, the “Real Decreto 384/2015” doesn´t completely solve the problems that already existed, with respect to the registration of leasing of aircraft in the Chattels Registry, since they remain applicable obsolete laws, as is the case of art. 180 of the Spanish Regulation of “Registro Mercantil” of 1956.Keywords: leasing contracts, civil aircrafts, Chattels Registry, Aircraft Registry, Real Decreto 384/2015, Regulation of “Registro Mercantil” of 1956.s
Дисертації з теми "CDM registry"
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Medina, Andrea-Li. "The weak registry the constitutionality and effectiveness of legal restrictions on convicted sex offenders." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/585.
Повний текст джерелаАнотація:
Over the last few decades our society has moved towards restricting where sexual offenders can live, work, and overall congregate. This issue has been the focus of great public attention due to the media's role in bringing these offenders to the light. Whether it is through the news, movies, TV series, books, talk shows, newspapers articles, etc., these offenders are constantly being talked about. Every body of government in the United States has moved towards implementing restrictions that are aimed at keeping sex offenders away from places where they are considered a potential danger. However, what it is not talked about is that in efforts to limit where sex offenders can live and work to ensure the safety of our society; we are isolating these offenders and hindering their reintegration into our society. By isolating sexual offenders from our society we are doing more harm than good because we are discriminating and not working to fit the needs of each individual offender. One size does not fit all. The intent of this thesis is to explore sexual offender legal restrictions, treatment, case law, constitutionality of these laws and to compare Florida's approach towards restriction of sexual offenders with other states. Through the analysis of case law and statutes, recidivism rates, and treatment options this thesis will evaluate what different approaches should be taken towards aiding the reintegration of sexual offenders into our society. This thesis will provide background information on sexual offenders, compare legal restrictions among states, give an analysis of sexual offender websites, and provide recommendations to a better approach in treating sexual offenders. By raising awareness to the unfairness of treatment of sexual offenders, this thesis aims to open a new gateway to determine more successful ways to rehabilitate sexual offenders.B.A. and B.S.
Bachelors
Health and Public Affairs
Legal Studies
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Debler, Julianna. "Has the pendulum swung too far? a legal evaluation of Florida's child abuse and neglect registry." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/539.
Повний текст джерелаАнотація:
Over the past several years, increasing public emphasis on preventing child maltreatment has resulted in substantial changes to Florida's child abuse and neglect central registry. Many of these recent changes, aimed at preventing child maltreatment, have resulted in over one million false, unsubstantiated, and inconclusive reports of child abuse and neglect within the last decade. While the information held in reports may be useful for identifying and preventing potential child abuse or neglect, due process concerns have been raised with regards to the process of placing a person's name in a report without providing a hearing for challenging or removing inaccurate information. Focusing on Florida law, this research concentrates on: 1) the child maltreatment reporting process, 2) the procedures for maintaining reports, and 3) the accessibility of these reports in order to determine whether due process constitutional rights are protected under Florida's child abuse and neglect reporting laws. The intent of this thesis is to analyze the occurrence of unsubstantiated cases of child maltreatment, incidences of false reporting, and legal remedies available for those wrongfully accused of abusing or neglecting a child. Through the analysis of case law, federal and state statutes, available statistics, child abuse resources, and personal interviews with members of the Florida Legislature, evidence shows that due process constitutional rights are not protected under Florida's child abuse and neglect reporting laws. By raising awareness of the areas of child protection that require legal re-evaluation, this thesis aims to discover the balance between protecting children from harm and protecting adults from the severe ramifications resulting from false and improper allegations of child abuse and neglect.B.S.
Bachelors
Health and Public Affairs
Legal Studies
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Chotiner, Robyn Richmond. "INVESTIGATION OF COGNITIVE AND PHYSICAL DEVELOPMENTAL ABILITIES OF YOUNG CHILDREN EXPOSED TO TACROLIMUS AND CYCLOSPORINE IN UTERO." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/142947.
Повний текст джерелаАнотація:
School PsychologyPh.D.
Kidney transplant recipients must take immunosuppressive medications to prevent the rejection of their transplanted kidney. If female transplant recipients become pregnant, however, very limited data are available about the effects of these medications on their exposed offspring. This study specifically reviews two of the most commonly used immunosuppressive medications prescribed to transplant recipients, cyclosporine and tacrolimus, and evaluates physical and cognitive development of the recipients' children who were exposed to these medications in utero. Participants in this study (n = 71) were female kidney transplant recipients who (a) voluntarily consented to be part of the National Transplantation Pregnancy Registry, (b) took cyclosporine or tacrolimus while pregnant, (c) had a child who is under the age of 6 years at the time of the study, and (d) were reachable via phone. Participants were asked standardized assessment questions related to their child's cognition and physical abilities from the Development Assessment of Young Children (DAYC). Standard scores from the assessment were recorded and analyzed to show that children exposed to cyclosporine or tacrolimus showed higher cognitive scores on the DAYC compared to the normative population. Children exposed to cyclosporine also showed higher physical scores compared to the normative population. Children exposed to tacrolimus did not show significant differences in physical development from the normative population. When cyclosporine or tacrolimus are required during pregnancy, these results help provide reassurance to parents and medical care providers about the cognitive and physical development of their offspring. Practical implications for school psychologists, limitations of this research, and directions for future research were discussed.
Temple University--Theses
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LoBasso, Thomas. "AN EVALUATION OF ENROLLMENT MANAGEMENT MODELS OF THE 28 FLORIDA COMMUNITY COLLEGES." Doctoral diss., University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2503.
Повний текст джерелаАнотація:
ABSTRACT The purpose of this study was to determine the extent to which enrollment management models have been successfully implemented within the 28 Florida community colleges. The study also sought to determine when enrollment management structures began and whether expected benefits were achieved. Analysis of the data collected in this study indicated the following five major findings. First, enrollment management concepts and practices have been implemented at some level within the 23 Florida community colleges surveyed. This was evident by the use of the word "enrollment" in the organizational titles as well as in the titles of the individuals who were responsible for the models. Second, enrollment management models reported were determined to be relatively new in comparison to four-year institutions. The literature on enrollment management demonstrated that four-year colleges began enrollment management practices in the early-to-mid 1970s. Much of the existing literature on enrollment management has been based on the experiences at four-year institutions. Third, some enrollment management divisions appeared to have key enrollment offices displaced. The key enrollment offices selected in this study were supported throughout the literature. Those offices represented were as follows: Admissions, Records and Registration, Financial aid, Orientation, and Advising. Fourth, increasing enrollment was the strongest reason for implementing the enrollment structure and subsequently was the strongest benefit realized. The anticipated decline in high school graduates, and the expectation of subsequent declining college enrollments during the 1970s, provided the impetus for the adoption of models of enrollment management. The fifth finding was that moving key enrollment offices such as financial aid into the enrollment management organizations would be an improvement to existing models. As enrollment management concepts are implemented into practice, the realignment of related offices may be necessary to effectively accomplish goals.Ed.D.
Department of Educational Research, Technology and Leadership
Education
Educational Leadership
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Guda, Dominic Robin. "A study to guide the design and implementation of a chronic disease management register in a regional health service." Phd thesis, 2012. http://hdl.handle.net/1885/11810.
Повний текст джерелаАнотація:
Background. The mounting burden of chronic disease associated with population ageing creates a challenge for health systems. Healthcare organisations are addressing this challenge by exploring new ways to improve patient health outcomes, including through the use of information technologies.
Aim. This research aimed to identify key design features of a chronic disease management (CDM) register for the public sector health services provided in the Australian Capital Territory.
Methods and setting. ACT Health, a government agency, is the largest health service provider in the ACT. An organisational analysis of ACT Health was conducted using qualitative, quantitative, and participant observation methods. Three index conditions- Chronic Heart Failure, Chronic Obstructive Pulmonary Disease, and Diabetes Mellitus Type 2 defined information according to the 'International Statistical Classification of Diseases and Health Related Problems: lOth Revision, Australian Modification' (ICD-10-AM) were chosen for data collection and analysis.
Results. ACT Health policies support evidence-based CDM interventions, but their implementation has been slow and disjointed. This research found that support for CDM in ACT Health is within the 'basic support' range as measured by the MacColl Institute's Assessment of Chronic Illness Care (ACIC) survey. The survey revealed continuity of care as a concern. On the positive side, factor analysis of the survey results identified a novel 'patient empowerment' factor that was strength within ACT Health. This patient empowerment factor is somewhat more than a concept; it is one of the powerful predictors of positive outcomes for CDM interventions, and has policy importance in this particular regional health system for working toward CDM goals.
In the participant observation aspect of this research, these findings were taken up to enrich the design features for an effective CDM register by incorporating the views of health professionals, patients and their carers. This research identified five data categories and associated variables required to support a CDM register. These five data categories are patient details, medical details, provider details, prevention details, and case coordination details. The prevention detail category is the centre of a CDM register intervention and consists of diagnostic, therapeutic and behavioural sub-categories. However, the research identified challenges regarding availability and completeness of these data in all five categories. Combining the survey and participant observation suggests that electronically incorporating standardised clinical information into a CDM register should enhance multidisciplinary communication, care planning and coordinated service delivery. A clinical data repository with data extraction and filtration systems compliant with the Health Level Seven International (HL7) metadata standard would enable the organisation to populate a CDM register's data fields from multiple sources.
Conclusion. A health service specific CDM register based on established data standards can actively support effective CDM interventions within the service. Further expansion toward a population-based CDM register would depend on implementation of local and national e-Health initiatives to standardise clinical information for automatic extraction into CDM registers. The research provides policy and design recommendations to further strengthen chronic care processes to benefit patients with chronic diseases, their carers and health service providers.
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Monteiro, Marta Ferreira 1978. "Characterization of CD8+ T-CELL populations of the human peripheral blood." Doctoral thesis, 2006. http://hdl.handle.net/10451/1847.
Повний текст джерелаАнотація:
Tese de doutoramento (Registo), Univ. de Lisboa, nº 28, 2009, (Immunologie), Université René Descartes - Paris V, 2009Following antigenic challenge, naïve CD8+ T lymphocytes undergo severalchanges, including the expression of cell-surface molecules. In humans, theassociation of CCR7, CD45RA, CD27 and CD28 is widely used to discriminate areproducible set of functionally different subpopulations of CD8+ T cells. However,the prevailing data concerning the description of these subsets remainsfragmentary, since a multitude of studies used a different and limited set of surfacemarkers. Hence, some CD8+ T-cell subsets are still not clearly established,especially within the CCR7 CD45RA+ and CCR7 CD45R0+ compartments, andthe correspondent differential roles and lineage relationships remain undisclosed.The present study aims to define a predictable and precise correlationbetween particular cell surface markers and CD8+ T-cell functional properties. Weassociated CCR7, CD45RA, CD27 and CD28 expression levels to subdivide CD8+T cells into fourteen different cell types. These populations were further isolatedand gene expression of 18 genes was assessed, simultaneously, in single-cells bya novel multiplex RT-PCR method we developed. Our results demonstrate that thedifferent subpopulations display distinct and characteristic gene co-expressionpatterns, reproducible between donors. CD45RA expression is required to definethe naïve subset, but does not discriminate functionally different populations ofprimed cells. In contrast, gene expression profiles of CCR7-CD8+ T cells correlatesignificantly to CD27 expression levels and CD27/CD28 co-expression, and ahierarchy of activation stages could be established as follows: naïve < CD27high
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Omran, Hesham. "Energy-Efficient Capacitance-to-Digital Converters for Low-Energy Sensor Nodes." Diss., 2015. http://hdl.handle.net/10754/582481.
Повний текст джерелаАнотація:
Energy efficiency is a key requirement for wireless sensor nodes, biomedical implants,
and wearable devices. The energy consumption of the sensor node needs to
be minimized to avoid battery replacement, or even better, to enable the device to
survive on energy harvested from the ambient. Capacitive sensors do not consume
static power; thus, they are attractive from an energy efficiency perspective. In addition,
they can be employed in a wide range of sensing applications. However, the
sensor readout circuit–i.e., the capacitance-to-digital converter (CDC)–can be the
dominant source of energy consumption in the system. Thus, the development of
energy-efficient CDCs is crucial to minimizing the energy consumption of capacitive
sensor nodes.
In the first part of this dissertation, we propose several energy-efficient CDC architectures
for low-energy sensor nodes. First, we propose a digitally-controlled coarsefine
multislope CDC that employs both current and frequency scaling to achieve
significant improvement in energy efficiency. Second, we analyze the limitations of
successive approximation (SAR) CDC, and we address these limitations by proposing
a robust parasitic-insensitive opamp-based SAR CDC. Third, we propose an
inverter-based SAR CDC that achieves an energy efficiency figure-of-merit (FoM)
of 31fJ/Step, which is the best energy efficiency FoM reported to date. Fourth, we propose a differential SAR CDC with quasi-dynamic operation to maintain excellent
energy efficiency for a scalable sample rate.
In the second part of this dissertation, we study the matching properties of small
integrated capacitors, which are an integral component of energy-efficient CDCs. Despite
conventional wisdom, we experimentally illustrate that the mismatch of small
capacitors can be directly measured, and we report mismatch measurements for subfemtofarad
integrated capacitors. We also correct the common misconception that
lateral capacitors match better than vertical capacitors, and we identify the conditions
that make one implementation preferable.
In the third and last part of this dissertation, we investigate the potential of novel
metal-organic framework (MOF) thin films in capacitive gas sensing. We provide
sensitivity-based optimization and simple fabrication flow for capacitive interdigitated
electrodes. We use a custom flexible gas sensor test setup that is designed and built
in-house to characterize MOF-based capacitive gas sensors.
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Cassim, Naseem. "Developing a laboratory based CCMT programme status reporting system in the Ekurhuleni Health District." Diss., 2013. http://hdl.handle.net/10500/13676.
Повний текст джерелаАнотація:
The purpose of this study was to develop a laboratory based Comprehensive Care, Management and Treatment of HIV and AIDS (CCMT) programme status reporting system using a methodological research study design. Quantitative data was collected using a request form and qualitative data was collected using structured questionnaires. For the study 1190 eligible CD4 samples were received, of which 1004 (84%) had a valid CCMT programme status. Overall 32% of the CD4 samples had a pre-ART status (n=383) and 52% had an ART status (n=621). The remaining 16% of CD4 samples (n=186) did not have a valid CCMT programme status. A pre-ART register was generated and assessed using a structured questionnaire. Based on the study findings a recommendation has been made to adopt the two-tick design for all NHLS request forms where programmatic data is collected. Additionally the CCMT programme status reporting system is recommended for rollout to other health districtsHealth Studies
M.A. (Public Health with specialisation in Medical Informatics)
Книги з теми "CDM registry"
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Chapel of Chorlton cum Hardy (Manchester, Greater Manchester). The Registers of Chorlton cum Hardy and Holme-in-Cliviger. Newport: Printed for the Lancashire Parish Register Society by Advertiser Printing Works, 1985.
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Nascimento, Guilherme, and José Antônio Baêta Zille. Notas de compositor – Edgar Alandia. Editora UEMG, 2020. http://dx.doi.org/10.36704/9788554780210.
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Notas de Compositor é uma série produzida em parceria com o Núcleo de Produção Editorial do Centro de Registro (CeR), da Escola de Música da UEMG, que objetiva registrar e difundir a produção cultural e artística de compositores no momento histórico concomitante à vida de seus atores. O primeiro volume é dedicado ao compositor boliviano Edgar Alandia e algumas de suas obras estão disponíveis abaixo.
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Greco Junior, Raul, Alessandra Dutra, and Givan José Ferreira dos Santos. Formação Docente Digital: Novas possibilidades de ensinar e aprender no ensino remoto. Vox Littera Publicações, 2021. http://dx.doi.org/10.55647/042021.
Повний текст джерелаАнотація:
Com as inovações tecnológicas presentes em diversos setores da sociedade, muita coisa mudou na vida das pessoas. Nos dias atuais, compra-se por meio de aparatos tecnológicos, estuda-se por ensino remoto, diverte-se em meio à navegação na internet, pratica-se a religiosidade de forma on-line e, com o surgimento desta impactante doença denominada Covi-19, até mesmo, trata-se da saúde usando a tecnologia. Na esfera educacional, a situação não poderia ser diferente. Desde o ano passado, em meio à pandemia de Covid-19, professores e alunos tiveram de se adaptar à nova realidade de estudos de forma remota. No mesmo momento, surgiu o curso Formação Docente Digital, o qual se caracterizou como um momento de construção de novos conhecimentos sobre o uso de tecnologias educacionais e troca de experiências. Sem esta pretensão, a formação aconteceu em momento muito propício, onde professores precisavam reinventar para trabalhar os conteúdos de sua disciplina de modo interativo, envolvente e eficaz. Muitas foram as inscrições para participar da formação e muitos foram os aprendizados. Desse aprendizado surgiu a possibilidade de registrar algumas propostas desenvolvidas e aplicadas ao longo do curso. Professores que enfrentaram, muitas vezes, os desafios da tecnologia ao preparar as suas aulas, também foram proativos para registar suas experiências na produção de capítulo para compor esta obra. O livro Formação Docente Digital conta com 09 capítulos que registram a elaboração, aplicação e análise dos resultados da aplicação de recursos tecnológicos voltados ao contexto escolar.
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McLafferty, Fred W. Registry of Mass Spectral Data: CD ROM with Structures, 5th Edition. John Wiley & Sons, 1989.
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de Oliveira Moura, Marcelo. Curso formação de mediadores em educação para redução de riscos de desastres no estado da Paraíba. Editora SertãoCult, 2022. http://dx.doi.org/10.35260/67960944-2022.
Повний текст джерелаАнотація:
Olá professor(a)! Seja bem-vindo(a) ao CURSO FORMAÇÃO DE MEDIADORES EM EDUCAÇÃO PARA REDUÇÃO DE RISCOS DE DESASTRES NO ESTADO DA PARAÍBA (ERRD PB)! A principal meta do Curso ERRD PB é de fomentar estratégias para a promoção e ampliação da cultura em ERRD no estado da Paraíba, através da interação/mediação dialógica com os(as) educadores(as) atuantes no ensino médio de escolas públicas situadas em municípios paraibanos com elevado grau de riscos de desastres ambientais. Diante disso, o conteúdo deste fascículo é introdutório ao Curso ERRD PB e tem como objetivo contextualizar o tema frente aos riscos de desastres ambientais. Entre os principais problemas de ordem ambiental e socioeconômica na Paraíba, aqui denominados de problemas socioambientais, destacam-se o expressivo número de registros de desastres ambientais. O estado da Paraíba apresenta 77,1% do seu território inserido na região Semiárida, tendo uma predisposição do meio natural à ocorrência de eventos climáticos extremos, em especial, os oriundos das anomalias negativas da precipitação (PARAÍBA, 2018). Segundo os dados oficiais da Secretaria Nacional de Proteção e Defesa Civil, a Paraíba se destaca no ranking nacional e regional por registrar um expressivo número de reconhecimentos de desastres ambientais, predominantemente, desastres climáticos (estiagem e seca) e hidrometeorológicos (inundações), que denominamos de desastres hidroclimáticos. Foram esses registros, além de outros, que motivaram a realização do Curso ERRD PB. Então professor(a), acreditamos que a sua participação para a mitigação/gestão dessa problemática socioambiental, juntamente com os seus alunos e de sua comunidade escolar, ou melhor, a partir de sua mediação como educador(a), você poderá ter um papel transformador dessa realidade. Que juntos possamos romper com a racionalidade impressa na resposta/recuperação dos desastres ambientais (foco nos desastres), para com isso avançarmos na ampliação de uma cultura de gestão dos riscos dos desastres (foco na gestão do risco), isto é, na promoção de uma cultura em ERRD!
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Araújo, Luís Fernando Ferreira de. Uma Infância Singular e Transformadora. Editora BAGAI, 2021. http://dx.doi.org/10.37008/978-65-89499-11-4.13.01.21.
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Minha paixão pelo magistério começou desde criança, com este livro registro este sonho em forma de palavra. A viagem do magistério fez-me compreender o quanto ser professor para mim é importante para minha vida que tanto me orgulho neste 35 anos de magistério. Objetivo deste livro é fornecer a você, leitor, a participar desta viagem comigo.
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Ramos De Siqueira, Joelson, and Juliana Sartori Bonini. Registro de marca - A importância da certificação. Brazilian Journals Editora, 2021. http://dx.doi.org/10.35587/brj.ed.0000953.
Повний текст джерелаАнотація:
Nos últimos tempos, principalmente depois dos momentos de isolamento causados pela pandemia, o e-commerce vem transformando a forma de consumo, tornando-o mais seguro e confortável. Hoje não basta apenas prestar serviços de qualidade, é preciso estar em evidência no mercado, alcançar o público-alvo e se tornar popular entre ele. A aprovação das marcas fica evidente em sua página na "web", nos “likes” que recebe e no engajamento que tem com o público, mostrando que estar presente no meio on-line é tão importante quanto qualquer outro ativo. Assim, a sua correta certificação é tão importante quanto obter um Cadastro Nacional de Pessoas Jurídicas (CNPJ).
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Agency, Co-operative Development, ed. How to register a community co-operative using the CDA 1984 model rules. London: Co-operative Development Agency, 1985.
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J, Jones Aidan C., Martin Janet D, and Lancashire Parish Register Society, eds. The registers of Egton, Finsthwaite & Satterthwaite. [Manchester]: Lancashire Parish Register Society, 1993.
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Nicolau, Marcos Fábio Alexandre. Nada é sem razão. Editora SertãoCult, 2020. http://dx.doi.org/10.35260/87429823-2020.
Повний текст джерелаАнотація:
Filósofo com uma das mais vastas obras, Leibniz segue atual, influenciando a produção de estudiosos de todo o mundo. Tal relevância é refletida neste livro, que traz um conjunto de textos sobre sua filosofia, fruto de parcerias com excelentes pesquisadores e intérpretes da obra de Leibniz. Assim, esta publicação almeja contribuir para o registro e a divulgação destas pesquisas filosóficas, ao mesmo tempo que reafirma o compromisso dos autores, enquanto pesquisadores e filósofos, em continuar promovendo o debate acadêmico em consonância com os anseios culturais e educacionais de nosso povo, principal justificativa para a presença da Filosofia como disciplina na educação básica, no ensino superior e no espírito democrático de nossa sociedade. Ideal que comungamos com Leibniz ao reverberar uma de suas mais famosas frases: “É uma das minhas convicções que devemos trabalhar para o bem comum, e que nos sentiremos felizes na mesma proporção que contribuirmos para isso”.
Частини книг з теми "CDM registry"
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Muralidharan, K., and K. Sridevi. "Reducing Power in Register Files for CAM- and SRAM-Based Processor Units." In Lecture Notes in Networks and Systems, 395–401. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3765-9_41.
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Puttmann, Daniel, Nicolette De Keizer, Ronald Cornet, Eric Van Der Zwan, and Ferishta Bakhshi-Raiez. "FAIRifying a Quality Registry Using OMOP CDM: Challenges and Solutions." In Studies in Health Technology and Informatics. IOS Press, 2022. http://dx.doi.org/10.3233/shti220476.
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The need for health data to be internationally Findable, Accessible, Interoperable and Reusable (FAIR) and thereby support integrative analysis with other datasets has become crystal clear in the ongoing pandemic. The Dutch National Intensive Care Evaluation (NICE) quality registry adopted the Observational Medical Outcomes Partnership Common Database Model (OMOP CDM) to achieve a FAIR database. In the process of adopting the OMOP CDM, many modeling, technical, and communication challenges needed to be solved. Through communication with the OMOP CDM implementation community, previously done research and trial-and-error we found solutions that we believe can help other healthcare institutions, especially ICU quality registries, FAIRify their databases.
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"Center for Defense Information (CDI)." In The Grants Register 2018, 235. London: Palgrave Macmillan UK, 2018. http://dx.doi.org/10.1007/978-1-349-94186-5_308.
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"Center for Defense Information (CDI)." In The Grants Register 2020, 248–49. London: Palgrave Macmillan UK, 2019. http://dx.doi.org/10.1057/978-1-349-95943-3_243.
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"Center for Defense Information (CDI)." In The Grants Register 2021, 273–74. London: Palgrave Macmillan UK, 2020. http://dx.doi.org/10.1057/978-1-349-95988-4_246.
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"Center for Defense Information (CDI)." In The Grants Register 2022, 296. London: Palgrave Macmillan UK, 2021. http://dx.doi.org/10.1057/978-1-349-96042-2_9837.
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"Center for Defense Information (CDI)." In The Grants Register 2019, 229. London: Palgrave Macmillan UK, 2018. http://dx.doi.org/10.1007/978-1-349-95810-8_310.
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"Center for Defense Information (CDI)." In The Grants Register 2023, 316–17. London: Palgrave Macmillan UK, 2022. http://dx.doi.org/10.1057/978-1-349-96053-8_9737.
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"V. Register." In Studien zu den substantivischen Bibelglossen des Clm 19440 aus Tegernsee, 421–56. Göttingen: Vandenhoeck & Ruprecht, 2000. http://dx.doi.org/10.13109/9783666203558.421.
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Santos, Anderson Pereira dos, Larissa Vasconcelos Santos, Karla Anastácia Ferreira de Almeida Melo, Rikelly Mirella Araújo Silva, and Cynthia Maria de Lyra Neves. "Registro da abelha Megachile Latreille (Apoidea, Megachilidae) residentes em ninhos artificiais." In Biodiversidade e interfaces com a Saúde, 52–58. Eduneal, 2021. http://dx.doi.org/10.48016/gt4l3xenccultcap4.
Повний текст джерелаТези доповідей конференцій з теми "CDM registry"
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Moreira, Pedro, Rodrigo Fonseca, Pedro Loures Alzamora, Ramon A. S. Franco, Janaina Guiginski, Evandro L. T. P. Cunha, Tereza Bernardes, et al. "Covid Data Analytics: Repositório de Dados Provenientes de Múltiplas Fontes sobre a Pandemia de COVID-19 no Brasil." In Dataset Showcase Workshop. Sociedade Brasileira de Computação, 2021. http://dx.doi.org/10.5753/dsw.2021.17419.
Повний текст джерелаАнотація:
Este artigo apresenta a construção e publicação de um repositório de dados utilizados e desenvolvidos no âmbito do projeto Covid Data Analytics (CDA), executado pelo Departamento de Ciência da Computação da UFMG. O projeto visou monitorar aspectos referentes à situação social, econômica e epidemiológica da COVID-19 no Brasil a partir da análise de dados provenientes de fontes oficiais e não oficiais, de redes sociais online e da web em geral. A construção do repositório, contendo 18 atributos e 1086 registros, se baseou na coleta direta de dados das fontes selecionadas, os quais foram posteriormente enriquecidos e, finalmente, disponibilizados por meio de uma ferramenta de busca desenvolvida exclusivamente para eles.
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Medvedovski, Nirce Saffer, Adriane Borda Almeida Da Silva, Elisa Santos Guimarães, Lourenço Kalil Tomaz, Glauco Roberto Munsberg, André Alba, Daniel Krolow, and Thales Teodoro. "APLICATIVO PARA REGISTRO DE MAPAS MENTAIS A PARTIR DE INTERFACE DIGITAL." In VII Encontro de Tecnologia de Informação e Comunicação na Construção - Edificações, Infra-estrutura e Cidade: Do BIM ao CIM. São Paulo: Editora Edgard Blücher, 2015. http://dx.doi.org/10.5151/engpro-tic2015-041.
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Safi, Elham, Andreas Moshovos, and Andreas Veneris. "A physical level study and optimization of CAM-based checkpointed register alias table." In Proceeding of the thirteenth international symposium. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1393921.1393982.
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Figueroa Tubío, Alexandre, Juan Ángel González Martín, Mar Rodríguez Cruz, Beatriz Merino Rodríguez, Eduardo Martín Arranz, Mariano González-Haba, Lucía Diéguez Montes, et al. "EXPERIENCIA INICIAL CON EL COLANGIOSCOPIO SPYGLASS-DS EN LA COMUNIDAD AUTÓNOMA DE MADRID (CAM): REGISTRO MULTICÉNTRICO." In 41 Congreso de la Sociedad Española de Endoscopia Digestiva (SEED). Madrid (España): Arán Ediciones, S.L., 2019. http://dx.doi.org/10.17235/reed.supl2vol111.1183/2019.
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Ribeiro, José Mauro, Ricardo Alencar, Gustavo Martins, Carolina Xavier, Alexandre Evsukoff, and Vinícius Vieira. "Caracterização da relação entre redes sociais e mobilidade de indivíduos em contextos urbanos." In Brazilian Workshop on Social Network Analysis and Mining. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/brasnam.2021.16123.
Повний текст джерелаАнотація:
A compreensão da organização urbana é fundamental para um melhor planejamento e definição de políticas públicas que visem maior bem estar da população e mitigação de problemas sociais. Modelos computacionais capazes de integrar dados de diferentes fontes podem auxiliar a caracterização da complexa organização geográfica e socioeconômica da população em áreas urbanas com grande resolução e aplicabilidade em contextos práticos. Este trabalho apresenta a análise da complexidade urbana representada pelas relações sociais e de mobilidade através da investigação de registros de ligações telefônicas armazenadas como Call Detail Records (CDR). Considerando duas cidades com características distintas, experimentos realizados a partir da caracterização da mobilidade individual das pessoas permitem observar uma forte interedependência entre seu comportamento de mobilidade no espaço urbano e o comportamento exibido pelas pessoas que definem sua rede social.
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Dias, Andrew D., Nathan R. Schiele, Brendan M. Carr, Nurazhani Abdul Raof, Yubing Xie, Douglas B. Chrisey, and David T. Corr. "Precise Patterning of Mouse Embryonic Stem Cells on Glass Cover Slips for High-Throughput Analysis Using Laser Direct-Write." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53573.
Повний текст джерелаАнотація:
Engineering a microenvironment where the growth substrate and distance between cells are controlled is highly desirable to understand how cellular interactions affect stem cell differentiation. Laser direct-write (LDW) allows rapid and precise placement of living cells via computer-aided design/computer-aided manufacturing (CAD/CAM) control. Application of this technique to study the effects of various stem cell microenvironments on differentiation requires a high-throughput experimental setup [1]. Recently, our lab has developed a gelatin-based LDW method for the precise patterning of sensitive cell types, such as mouse embryonic stem cells (mESCs), at a resolution of about 5 μm [2]. Although viable mESCs were successfully printed with maintained pluripotency, this technique required cells to be patterned onto polystyrene Petri dishes [2,3], which may limit high-throughput efficiency. Moreover, the use of polystyrene Petri dishes requires large quantities of culture medium and is not convenient for biological analysis of mESC differentiation. Therefore, the objective of this study was to adapt the LDW method, without altering its prior success, to transfer patterns of viable mESCs to glass cover slips. However, this adaptation to cover slips could not be achieved through simple downscaling due to the unique challenges of providing sufficient moisture for viable cell transfer while maintaining pattern registry on a cover slip. Once cells have been laser patterned, cover slips can then be moved to a 24-well plate so that separate sets of laser patterned cells can be analyzed in parallel for higher experimental throughput utilizing fewer resources to maintain the cells.
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Martínez-Guanter, Jorge, Fabio Tucci, O. Enrique Apolo Apolo, Juan Agüera, Gregorio Egea, Dionisio Andújar, and Manuel Pérez-Ruiz. "Diseño y primeros resultados de una plataforma móvil eléctrica de registro de datos para agricultura de precisión." In X Congreso Ibérico de Agroingeniería = X Congresso Ibérico de Agroengenharia. Zaragoza: Servicio de Publicaciones Universidad, 2019. http://dx.doi.org/10.26754/c_agroing.2019.com.3395.
Повний текст джерела
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Silveira, Jonathas, Isaías Felzmann, João Fabrício Filho, and Lucas Wanner. "RV-Across: An Associative Processing Simulator." In XXI Simpósio em Sistemas Computacionais de Alto Desempenho. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/wscad.2020.14064.
Повний текст джерелаАнотація:
Associative Processing provides high-performance and energyefficient parallel computation using a Content-Addressable Memory (CAM). Emerging big data applications can be significantly sped-up by Associative Processing, but validation and evaluation are key challenges. We present RVAcross, a RISC-V Associative Processing Simulator for testing, validation, and modeling associative operations. RV-Across eases the design of associative and near-memory processing architectures by offering interfaces to both building new operations and providing high-level experimentation. Our simulator records memory and registers states of each associative operation pass, giving the user visibility and control over the simulation. The user can employ the simulation statistics provided by RV-Across to compute performance and energy metrics. RV-Across implements common associative operations and provides a framework to allow for easy extension. We show how the simulator works by experimenting with different scenarios for associative operations with three applications that test the functionality of logic and arithmetic computations: matrix multiply, checksum, and bitcount. Our results highlight the direct relation between the data length and potential performance improvement of associative processing in comparison to regular CPU serial and parallel operation. In case of matrix multiplication, the speed-up increases linearly with matrices dimension, achieving 8X for 200x200 bytes matrices and overcoming parallel execution in an 8-core CPU.
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Niemi, Arto, Tobias Höbbel, and Frank Sill Torres. "Risk Register Database to Improve Organizational Resilience and Knowledge Management." In Proceedings of the 31st European Safety and Reliability Conference. Singapore: Research Publishing Services, 2021. http://dx.doi.org/10.3850/978-981-18-2016-8_072-cd.
Повний текст джерела
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Bohm, Emanuelle Fick, and Ernesto de Paula Guedes Neto. "Metástase de carcinoma de sítio primário de mama para o trato genital feminino: relato de caso e revisão de literatura." In 44° Congresso da SGORJ - XXIII Trocando Ideias. Zeppelini Editorial e Comunicação, 2020. http://dx.doi.org/10.5327/jbg-0368-1416-2020130245.
Повний текст джерелаАнотація:
Introdução: Os sítios mais comuns de metástases de câncer de mama são pulmões, ossos, fígado e cérebro. Sítios menos comuns incluem trato gastrointestinal, pâncreas, baço, tireoide, adrenais, rins, coração e trato genital feminino (TGF). As metástases no TGF de sítios primários distantes são incomuns, mas quando se apresentam, tendem a estar envolvidas com os ovários ou o endométrio. O relato deste estudo retrata a ocorrência de neoplasia maligna metastática paratubária em paciente com carcinoma primário de mama. Objetivos: Relatar o caso de uma paciente com metástase de carcinoma de sítio primário de mama para o TGF e revisar na literatura disponível tal ocorrência. Material e Métodos: As informações do caso foram obtidas a partir da revisão de prontuário, registro fotográfico diagnóstico da paciente e revisão de literatura. A revisão foi realizada na base de dados do PubMed, em estudos publicados nos últimos 20 anos (2000‒2020), com os termos “breast cancer” AND “metastasis” AND “female genital tract”. Os artigos selecionados foram estudos meta-analíticos, casos clínicos e revisões na língua inglesa. Resultados e Conclusão: Paciente, sexo feminino, 70 anos, G1P1. Há 20 anos submetida à mastectomia esquerda apresentando carcinoma ductal invasor (CDI), com RE e RP positivo e Human Epidermal growth factor Receptor-type 2 (HER2) negativo. Realizou histerectomia com anexotomia profilática com diagnóstico de neoplasia maligna metastática em tuba esquerda com 1:1 cm no maior eixo. Exame imuno-histoquímico apresentando GATA3 negativo, CK7, Mamoglobina, PAX8, RP e RE positivos. Exames laboratoriais e de imagem pré-operatórios negativos para neoplasia. O CDI é o tipo mais comum de câncer de mama invasivo, seguido pelo carcinoma lobular invasivo (CLI). Contudo, metástases para o TGF são mais frequentemente associadas ao CLI do que ao CDI. Estima-se que mais de 80% dos cânceres de mama que metastatizam para o TGF são CLI. Um estudo realizado em mulheres com metástase ginecológica (n=54) demonstrou que 42,6% tinham câncer de mama correspondente a CLI; 48,1%, carcinoma invasor sem tipo específico; e 9,3%, outros. Além disso, o estudo revelou que os sítios de metástases ginecológicas mais envolvidos foram os ovários, seguido das tubas e do útero. A respeito da expressão de biomarcadores de tumores primários que se espalharam para sítios ginecológicos, 93,5% expressou RE positivo; 65,7%, RP positivo; e 0%, HER2 positivo. Uma avaliação de 13 casos mostrou que, enquanto a expressão de RE e FOXA1 foi mantida ou aumentada durante a progressão para órgãos ginecológicos, a expressão de proteínas acessórias envolvidas com a regulação hormonal diminuiu. Conforme o aumento do tumor, as células que expressam RP, RA e GATA3 em metástases distantes diminuíram em 69,2, 38,5 e 46% dos casos, respectivamente. O relato em questão confirma os resultados obtidos nos estudos, já que apresenta semelhança na expressão gênica de carcinomas primários de mama com metástase para o TGF. No entanto, apresenta um histotipo incomum para metástases ginecológicas.
Звіти організацій з теми "CDM registry"
1
Wei, Yuehui, Hui Mao, Ziyun Jiang, Luyao Liu, Yuqiao Quan, and Xun Li. Efficacy and safety of Zuogui Wan combined with conventional Western medicine for postmenopausal osteoporosis: A protocol for a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0099.
Повний текст джерелаАнотація:
Review question / Objective: The proposed systematic review of randomized controlled trials (RCTs) will address the effectiveness and safety of Zuogui Wan combined with conventional Western medicine (CWM) for osteoporosis in postmenopausal women, and provide reference for clinical practice. Information sources: We will use computers to search PubMed, Cochrane Library, Embase, Web of Science, Chinese National Knowledge Infrastructure database (CNKI), WanFang database, Chinese Biomedical Database (CMB), Chinese Science and Technology Periodical database (VIP), China Master’s Theses Full-text Database (CMFD), China Proceedings of Conference Full-text Database (CPFD), WHO International Clinical Trials Registry Platform (ICTRP), Chinese Clinical Trials Registry (ChiCTR) and ClinicalTrials.gov, and select all eligible RCTs from inception to October, 2021. Clinicians will also be consulted for additional studies.
2
Zou, Yihua, Fangqin Tong, Meng Guan, Chun Bi, and Xia Wang. Efficacy and safety of Anti-angiogenesis combined with chemoradiotherapy in the treatment of locally advanced cervical cancer: A Meta-Analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0077.
Повний текст джерелаАнотація:
Review question / Objective: To Systematicly evaluate of the clinical efficacy and safety of the combination of anti-angiogenesis and simultaneous radiotherapy in the treatment of cervical cancer. Condition being studied: Locally advanced cervical cancer. We searched databases including PubMed, Cochrane Library, Embase, Web of Science CNKI, Wanfang, VIP and CBM, and the International Clinical Trial Registry Platform (ICTRP) and the Chinese Clinical Registry(ChiCTR) to collect the clinical studies about the randomized controlled trial (RCTS) of anti-angiogenic drugs (mainly Endu, apatinib and bevacizumab) combined with chemoradiotherapy in the treatment of cervical cancer. The time limit is from the establishment of the database to April 2022. RevMan 5.4 software was used to analyze the short-term efficacy and the incidence of adverse reactions.
3
Rocha, Rafaella Estevão da. 1º Colóquio virtual da Sobrac NE: Arquitetura e Acústica no Ambiente Construído: a receita do 1° Colóquio Virtual “Cuscuz com Acústica” da Sobrac NE. Revista Acústica e Vibrações, December 2021. http://dx.doi.org/10.55753/aev.v36e53.53.
Повний текст джерелаАнотація:
Este documento registra brevemente o contexto de realização do 1° Colóquio Virtual Cuscuz com Acústica da Regional Nordeste da Sobrac. Desse modo, a seguir são discutidas as interfaces sobre o surgimento do evento e sobre o processo de apoio dos Conselhos de Arquitetura e Urbanismo regionais. Apresentam-se as temáticas debatidas no colóquio e são relatados os desafios para seu planejamento e execução. Por fim, encerra-se o documento com um relato de curiosidades sobre o nome do colóquio, informando também o alcance obtido.
4
Foster, Stephanie, Amy M. Lavery, Suzanne K. Condon, Alisha Etheredge, Kennedy Brian, Svendsen Erik, and Breysse Patrick. Guidelines for examining unusual patterns of cancer and environmental concerns. National Center for Environmental Health (U.S.), December 2022. http://dx.doi.org/10.15620/cdc:122695.
Повний текст джерелаАнотація:
The Centers for Disease Control and Prevention (CDC) National Center for Environmental Health (NCEH) and the Agency for Toxic Substances and Disease Registry (ATSDR) provide scientific guidance to state, tribal, local, and territorial (STLT) health departments related to environmental health concerns. The guidelines presented here update the 2013 publication, “Investigating Suspected Cancer Clusters and Responding to Community Concerns: Guidelines from the CDC and the Council of State and Territorial Epidemiologists (CSTE)”.1 In general, STLT health departments play the primary role in examining unusual patterns of cancer in communities, including those associated with local environmental concerns. These guidelines expand the approach for these investigations. Occupation-related clusters are not included in these guidelines. Publication date from document properties. CS336302-A Guidelines-for-Examining-Unusual-Patterns-of-Cancer-and-Environmental-Concerns-h.pdf
5
Zeng, Siyao, Lei Ma, Lishan Yang, Xiaodong Hu, Xinxin Guo, Yi Li, Yao Zhang, et al. Advantages of damage control surgery over conventional surgery inmultiple trauma: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0006.
Повний текст джерелаАнотація:
Review question / Objective: This meta-analysis aims to explore whether damage control surgery has advantages over traditional surgery in the treatment of multiple trauma. Information sources: The Chinese Biomedical literature (CBM), Chinese National Knowledge Infrastructure (CNKI), Weipu (VIP), Duxiu, WanFang, Web of sciense, PubMed, Scopus, Ovid, EMbase, ProQuest, Cochrane, Chinese clinical trial Registry and Clinical Trials.gov databases. Main outcome(s): mortality rate, the success rate of rescue, In-hospital length of stay, ICU length of stay, the overall incidence rate of complications, incidence of disseminated intravascular coagulation (DIC), incidence of multiple organ dysfunction syndrome (MODS) , incidence of shock.
6
Qu, Pengda, Jing Huang, Shiqi Wang, Size Li, Qian Hu, Wei Wang, and Xiaohu Tang. Efficacy and safety of modified Ermiao decoction in the treatment of gouty arthritis: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0063.
Повний текст джерелаАнотація:
Review question / Objective: The purpose of this study is to comprehensively evaluate the efficacy and safety of modified Ermiao decoction in the treatment of gouty arthritis. Information sources: We will conduct searches of Web of Science, PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang), Weipu Chinese Science and Technology Journal Full-text Database (VIP), and Chinese Biomedical Literature Database (CBM) from their inception to July 2022. In addition, trial registration platforms will also be searched for ongoing or unpublished trials, including International Clinical Trials Registry Platform and Chinese Clinical Trial Registry Centre. The languages of included studies will be restricted in English and Chinese. Medical Subject Headings and free words terms will be used during the retrieval process. The main search terms include “gouty arthritis”, “modified Ermiao”, and “randomized controlled trial.” A draft of the PubMed search strategy is included in Table 1. Similar retrieval strategies will be applied to the other databases mentioned above. We will also search for relevant systematic reviews of using MED for GA and reference lists of eligible studies to improve recall ratio.
7
Tan, Aihua, Yan Hu, Han Yan, Zheng Zhang, Ziyu Song, and Simiao Ran. Efficacy and safety of Chinese Herbal Medicine for Vascular dementia: A protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0098.
Повний текст джерелаАнотація:
Review question / Objective: As a common type of clinical dementia, the prevalence rate of vascular dementia(VaD) increased rapidly in recent years, damaging both patients’ health and social-economic prospect. There is currently no effective treatment for VaD, though western medicines can slightly improve patients' cognitive function, but not brought a significant improvement in daily life ability. Chinese herbal medicine(CHM) has been widely employed to treat dementia for more than 2000 years in China. Despite the proliferation of relevant literature, there is still a lack of evidence to prove the effectiveness and safety of such therapy. Therefore, this systematic review and meta-analysis protocol is aimed to assess the efficacy and safety of CHM forVaD. Information sources: 6 English databases (PubMed, Web of Science, Embase, Springer, CENTRAL and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wan fang Database, Chinese Scientific Journals Database, China National Knowledge Infrastructure Database and Chinese Biomedical Literature Database).
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Wu, Junsong, Xuefeng Liu, Hejing Liu, Yang Wang, Zhili Xiong, Minyi Shen, and Kun Zhong. Chinese Herbal Medicine Combined with Acupuncture-related therapy as Complementary Therapies for Diabetic Nephropathy: A Protocol for Systematic Review and Network Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0095.
Повний текст джерелаАнотація:
Review question / Objective: Evaluating the efficacy of various Chinese herbal medicines combined with acupuncture-related therapies in the treatment of diabetic nephropathy. Information sources: We will search the following databases for relevant randomised controlled trials: PubMed, EMBASE, Cochrane Library, Scopus, OVID,Web of Science, Cochrane Central Register of Controlled Trials, China Biology Medicine (CBM), the China National Knowledge Infrastructure (CNKI), Wanfang data, and the Chinese Scientifific Journal Database (VIP). Search until April 10, 2022, with a combination of MeSH terms and free words.
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Zhang, Hengdi, Yunming Li, Guangyu Chen, Fei Han, and Wei Jiang. Human amniotic membrane graft for refractory macular hole: a single-arm meta analysis and systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0098.
Повний текст джерелаАнотація:
Review question / Objective: Currently, pars plana vitrectomy (PPV) with ILM peeling is the gold standard treatment for full thickness macular hole (FTMH). Despite of the high macular hole closure rate, a refractory FTMH may occur. The next step for a recurrent or persistent MH is usually repeat PPV with extended ILM peeling. This is not always an option especially with high myopia patients or those who had already undergone an aggressive ILM peeling at initial surgery. A variety of novel techniques have been developed to address this issue, among which human amniotic membrane seems to be a promising adjuvant. However, there are still uncertainties regarding the integration and the long-term effects of of the graft. Information sources: PubMed, Embase, Web of science, Cochrane library, Wanfang Data Knowledge Service Platform, China National Knowledge Infrastructure databases, sinomed (CBM), VIP database, Clinical Trails.gov and Chinese Clinical Trail Registry.
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Estevens, Ana, Fabian Pavel, Agustín Cocola-Gant, and António Lopez-Gay. Reabilitação e turismo na cidade de Lisboa. Policy Brief. Centro de Estudos Geográficos, Universidade de Lisboa, September 2022. http://dx.doi.org/10.33787/ceg20220003.
Повний текст джерелаАнотація:
- Ao longo das últimas duas décadas o Estado Português e a Câmara Municipal de Lisboa têm fomentado políticas públicas de reabilitação destinadas a incentivar a atração de capitais transnacionais,encorajando o seu investimento no imobiliário e no turismo. - Em Lisboa, o setor do turismo tornou-se um dos principais eixos estratégicos da retoma económica pós crise financeira de 2008, merecendo especial destaque as freguesias centrais da cidade. - Neste período, os registos de Alojamento Local (AL) e os hotéis têm vindo a aumentar. Segundo o Turismo de Portugal, os AL passaram de 46 em 2009 para 19.300 em 2021. Este aumento é especialmente relevante nas freguesias centrais da cidade (Arroios, Misericórdia, Santa Maria Maior, Santo António e São Vicente) onde se localiza 71% do AL. A mesma fonte identifica que desde 2009 abriram mais 137 hotéis, sendo que 106 destes se localizam nas freguesias centrais. - Paralelamente, entre 2011 e 2021, perderam-se 1,2% dos alojamentos familiares. Este valor aumenta nas freguesias centrais para 18%, onde se nota, também, uma perda populacional (-19%). Destacam-se as freguesias da Misericórdia e de Santa Maria Maior que perderam, respetivamente, 17,9% e 27,8% dos seus alojamentos familiares, e 26,1% e 22% dos seus habitantes. No total das 5 freguesias centrais nota-se também uma perda de população (-19%) (INE). - Verificámos a substituição da habitação por estabelecimentos turísticos relacionada com processos de reabilitação. Apurámos que 34% dos edifícios existentes nas freguesias centrais tiveram, na última década, alvará para reabilitação, sendo que 82,3% dessas reabilitações deram lugar a AL e a hotéis (CML). - Em Lisboa, a habitação disponível quer para venda, quer para arrendamento sofreu um aumento exponencial do seu valor/m2. Entre 2010 e 2009, o valor da venda aumentou 70,9% e o do arrendamento 54,7%. Nos mesmos anos, nas freguesias do centro da cidade o valor da venda/m2 aumentou 99,4% e o do arrendamento 50,4% (Confidencial Imobiliário). Contudo, os salários médios, entre 2009 e 2019, aumentaram 15,85% (INE). - Em última instância, uma parte consistente da reabilitação de que foi alvo o edificado da cidade, não foi destinada a melhorar as condições habitacionais dos residentes. Criaram-se desigualdades sócio-espaciais evidentes, que se destacam nas freguesias centrais, em que a habitação perdeu a sua função social, dando lugar a edifícios para uso turístico.