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Добірка наукової літератури з теми "Canali al sodio"

Автор: Grafiati

Опубліковано: 10 березня 2023

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Статті в журналах з теми "Canali al sodio"

Navines, Ferran, Joan Bou, Lluís Planas, and Xavier Paunero Amigo. "Développement socio-économique du littoral catalan / Socio-economic development of the Catalan coast (Spain)." Cahiers du Centre nantais de recherche pour l'aménagement régional 47, no. 1 (1997): 411–16. http://dx.doi.org/10.3406/canan.1997.1747.

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Kadirov, Odiljon, and Khojiakbar Khasanov. "Analytical conclusions and proposals for technical condition and effective use of facilities on Tashkent magistral canal." E3S Web of Conferences 365 (2023): 03010. http://dx.doi.org/10.1051/e3sconf/202336503010.

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The socio-economic development of the Tashkent region (Uzbekistan) depends largely on natural resources, especially water resources, as in other regions. One of the canals that supply water to the Tashkent province is the Tashkent magistral canal (TMC). In terms of size, the second of the canals receives water from the left bank of the Chirchik River. The TMC has been 82 years since its start of use. Hydrotechnical facilities on the TMC are typical of the II class. There are many hydrotechnical facilities on the canal: one main structure, four water dampening facilities, two destructive water discharges, four duckers in the canal, 45 water dischargers, one waterfall, seven under-canal duckers, two pipes under the canal, nine aqueducts, nine canal access, thirteen road bridges, one railway bridge, one pedestrian bridge. This article presents the technical condition of the TMC and its hydrotechnical facilities and recommendations developed based on the technical condition. On April 9-13, 2022, field observation work was carried out to study the technical condition of the TMC and hydrotechnical facilities. It reviewed the availability of technical documents of TMC facilities, instructions for their use, information on maintenance of mechanical equipment, working drawings, previous inspection reports, and other materials. In addition, the conclusions of the inspection carried out by the State Inspection "Davsuvkhujalikzorat" and the results of the technical inspections carried out by the employees of the TMC administration and project parameters of water facilities were studied.

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GALIMOV, I. M., S. N. LEVACHEV, E. A. AGAFONOVA, and D. D. ALEXANDROVA. "ABOUT THE RESULTS OF COMPARISON OF THE PROJECTS OF THE «EURASIA» AND «VOLGO-DON 2» CANALS CCORDING TO THE MAIN TECHNICAL PARAMETERS." Prirodoobustrojstvo, no. 2 (2021): 85–91. http://dx.doi.org/10.26897/1997-6011-2021-2-85-91.

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The purpose of this article is to compare major infrastructure projects of the water transport connection between the Caspian Sea and the Azov-Black Sea basin –the «Eurasia» canal and the «Volgo-Don 2» canal on the following parameters of comparison: the height of the watershed, the length of the canals, water supply of canals, the conditions and intensity of navigation. The need to build a new shipping canal is due to the projected increase in the volume of cargo transportation from the Caspian Sea that will cause difficulties in the existing Volgo-Don canal. The authors of the study have analyzed and summarized the research materials containing information about the design decisions on the «Eurasia» canals and the second branch of the Volgo-Don shipping canal. Realization of the project canal «Eurasia» will significantly decrease the delivery time of cargoes, including oil from the Caspian Sea and Central Asian countries to the Black and Azov sea; cut the cost of transportation between these regions in comparison with transportation by «VDSC2» (by reducing the length of the waterway); increase in the strategic plan the reliability and safety of water transport links of the two seas basins on parallel directions; create conditions for socio-economic and industrial development of the canal region s. adjacent to the track. In the case of «VDSC-2», the following prospects for construction are highlighted: to ensure the passage of the additional cargo flow expected in connection with the growth of industrial production in Russia in recent years and the corresponding increase in the traffic of industrial and agricultural goods by water transport; to strengthen Russia’s political and economic infl uence on the countries of the southeast region and the European community; to intensify the development of the domestic shipbuilding to create a specialized fl eet for effi cient operation in the conditions of international transportation on internal and external waterways; to increase capacity and, consequently, the economic efficiency of the operation of international transport corridors «North-South» and «East-West».

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Diallo, Mamadou B. C., Alfredo J. Anceno, Benjawan Tawatsupa, Nitin K. Tripathi, Voranuch Wangsuphachart, and Oleg V. Shipin. "GIS-based analysis of the fate of waste-related pathogens Cryptosporidium parvum, Giardia lamblia and Escherichia coli in a tropical canal network." Journal of Water and Health 7, no. 1 (October 1, 2008): 133–43. http://dx.doi.org/10.2166/wh.2009.010.

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Urban canals play a major socio-economic role in many tropical countries and, particularly, Thailand. One of the overlooked functions that they perform is a significant attenuation of waste-related pathogens posing considerable health risk, as well as pollution attenuation in general. The study dealt with a comparison of three canals receiving: (i) municipal, (ii) mainly industrial and (iii) mainly agricultural wastewater, listed in order of progressively decreasing organic loading. The occurrence and fate of waterborne Cryptosporidium parvum, Giardia lamblia and Escherichia coli were monitored in the canals by both real-time PCR and conventionally for 12 months. The pathogens are etiological agents of an estimated 38% and 47% of diarrhea cases worldwide and in Thailand, respectively. The geographic information system (GIS) was used to evaluate and map point and, particularly, non-point pollution sources which allowed differentiating the canal sections in terms of predominant pathogen sources. The flowthrough canals, which can be viewed as waste stabilization ponds, were found to be efficiently removing the pathogens at the following generalized specific rates: 0.3 (C. parvum), 1.2 (G. lamblia), 1.8 (E. coli) log10/km.d in the dry season. The rates decreased in the rainy season for E. coli and G. lamblia, but increased for C. parvum which indicated different removal mechanisms. Data suggest that E. coli and G. lamblia were mainly removed through sedimentation and sunlight (UV) irradiation, while the likely mechanism for C. parvum was predation. Overall, the specific pathogen removal rates positively correlated with the canal organic loading rates in the rainy season. As an important result, an estimate of the municipal pollution mitigation by over 2,280 km canals in the Greater Bangkok suggests that concomitant to the pathogens at least 36–95 tons of BOD5 is being removed daily, thereby saving the receiving Chao Phraya River and Bight of Bangkok, by far exceeding current, from major eutrophication problems.

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Chaussade, Jean. "La Baie de Bourgneuf : les formes socio-spatiales de la pêche." Cahiers du Centre nantais de recherche pour l'aménagement régional 27, no. 1 (1986): 79–102. http://dx.doi.org/10.3406/canan.1986.1371.

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Akhter, Sajjad, and Basit Nadeem. "The Dynamics of Canal Colonies; Agricultural Development and Socio-Political Change in British Multan." PERENNIAL JOURNAL OF HISTORY 2, no. 2 (December 10, 2021): 91–103. http://dx.doi.org/10.52700/pjh.v2i2.63.

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Punjab was the last province which annexed with British India in 1949.British implemented many reforms in sub-continent, but Canal Colonies were excellent irrigation system introduced by the British, especially in the south west part of the Punjab province. These canal colonies proved very useful for the agriculture sector which boost up the not only the economic condition of the native people of the colonies areas but also increase revenue collection of the British government in India. Canal Colonies changed the arid/ barren land of the southern district of the province into a fertile land. British government also achieved their objectives through canal colonies. Therefore, government allotted the land of the canal colonies in different categories and rewarded some specific classes in native communities of the canal colonies. In canal colonies government reserved huge piece of land for their military objective because Indian Military was necessary for the strong law and order in British India and their strong influence in Middle East and other parts of the world. These canal colonies bring an agriculture revolution in the province which change the socio-economic condition of the people of the native districts. In Multan three major canal colonies were introduced, Sidhnai, Lower Bari Doab and Nili Bar canal colony. In these canal colonies British government also implemented same polices like the previous canal colonies of the province. Therefore, the in Multan district landed elites were loyal and cooperative with government with their wealth and men. These landed elites played important role at political canvas of the province during British rule in Multan.

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Polèse, Mario. "Clermont DUGAS, Disparités socio-économiques au Canada." Recherches sociographiques 30, no. 1 (1989): 121. http://dx.doi.org/10.7202/056416ar.

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BENDJABALLAH, Soumaia, Rédha LAKEHAL, Farid AIMAR, Rabeh BOUHARRAGA, Rafik NEZZAL, Fateh GUERITI, and Abdelmalek BOUZID. "Surgical management of the arterial duct in the era of percutaneous closure." Batna Journal of Medical Sciences (BJMS) 6, no. 1 (July 1, 2019): 40–43. http://dx.doi.org/10.48087/bjmsoa.2019.6111.

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Introduction. La fermeture percutanée du canal artériel persistant est actuellement la méthode de choix ; cependant, certaines conditions socio-économiques défavorables font que la chirurgie reste le seul moyen thérapeutique. Objectif. Evaluer la place de la chirurgie par rapport à la fermeture percutanée. Matériel d’étude. De 2001 à 2018, 254 patients ont été opérés à l’EHS Djeghri Mokhtar. L’Age a varié entre 1 et 48 ans. Le sexe féminin est prédominant. La voie d’abord avait consisté en une thoracotomie postéro-latérale gauche chez 252 patients et une sternotomie chez 2 patients. Résultats. Le traitement a consisté en une section – suture du canal chez 244 patients et une ligature chez 10 patients. La durée d’hospitalisation était 9,5 jours. La mortalité précoce et tardive est nulle. Discussion. Au cours des 20 dernières années, la fermeture percutanée est devenue la principale approche du traitement des canaux artériels. Cependant, tous les patients ne sont pas éligibles à ce type de traitement. En présence d’une forte hypertension artérielle pulmonaire, beaucoup d’auteurs sont en faveur de la chirurgie, le risque d'embolisation du matériel étant très élevé si la fermeture percutanée est envisagée. Chez les nouveau-nés prématurés, la stratégie thérapeutique actuelle est une ligature chirurgicale par thoracotomie, la fermeture percutanée a été récemment proposée comme une alternative à la chirurgie afin d’éviter ainsi la thoracotomie. Conclusion. La fermeture percutanée des canaux artériels a éclipsé la chirurgie, cependant, les conditions socio-économiques défavorables rendent ce procédé souvent illusoire et par conséquent, la chirurgie du canal artériel garde toujours sa place.

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Piñeiro Antelo, Anxeles, and Xosé Santos Solla. "La culture de la moule en Galice : aspects socio-économiques et spatiaux / Mussel production in Galicia (Spain) : socioeconomic and spatial aspects." Cahiers du Centre nantais de recherche pour l'aménagement régional 47, no. 1 (1997): 125–32. http://dx.doi.org/10.3406/canan.1997.1702.

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Patriquin, M. N., J. R. Parkins, and R. C. Stedman. "Socio-economic status of boreal communities in Canada." Forestry 80, no. 3 (June 11, 2007): 279–91. http://dx.doi.org/10.1093/forestry/cpm014.

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Більше джерел

Дисертації з теми "Canali al sodio"

Bechi, G. "EPILESSIA E CANALI VOLTAGGIO DIPENDENTI DEL SODIO: MECCANISMI PATOGENETICI." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150168.

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The SCN1A gene, coding for the isoform Nav1.1 of voltage gated sodium channels, is the main target of epileptogenic mutations. Mutations in this gene have been identified in about 80% of patients affected by Severe Myoclonic Epilepsy of Infancy (SMEI), in about 10% of patients suffering from Generalized Epilepsy with Febrile Seizures Plus (GEFS+). Nav1.1 mutations that cause GEFS+ are missense mutations, whereas those that give rise to the much more severe disorder SMEI can either be missense ones or result in truncated channels that are predicted to be non-functional. Several evidences point to loss of function as the main effect of Nav1.1 mutations. It is puzzling that loss of function mutations in Nav1.1 lead to epilepsy, a disorder characterized by brain hyperexcitability; however, data from Nav1.1 knock out and knock in mice indicate that Nav1.1 is the predominant isoform in at least some types of inhibitory interneurons. Previous data on mutant of Cav1.2, Nav1.2 and Nav1.5 suggest that truncated proteins can exert dominant-negative effects, contributing to more severe phenotypes. Therefore we hypothesized that also SMEI truncation mutants could have dominant-negative effects, explaining the more severe phenotype in comparison with GEFS+. In the first project we have studied the effects of the SMEI mutations R222X and R1234X on hNav1.1, hNav1.2 and hNav1.6. Patch-clamp analysis of coexpressed mutants and wild type channels in tsA201 cells showed that both truncated mutant proteins had no effect on the expression of wild type channels; however, the truncated proteins modified the gating properties of Nav1.1 and Nav1.6, worsening their loss of function. It is known that some Nav1.1 missense mutation cause loss of function because of folding defects. We have previously demonstrated that two mutations located in the C-terminus cause loss of function inducing folding defects, thus retention in the endoplasmic reticulum and probably degradation (Rusconi et al., 2007 and 2009). Moreover, we have shown that the folding of the mutant channel can be stabilized by the co-expression of interacting proteins or incubation with pharmacological chaperones, leading to a partial restoration of the expression on the plasma membrane and therefore to a partial recovery of its activity. It is possible to speculate that differences in the expression levels or the presence of polymorphisms in the accessory proteins could influence the interaction with the misfolded channel, inducing a differential degree of rescue which possibly determines the severity of the pathology and therefore the phenotypic variability. In the second project, to understand if misfolding could be considered a common pathogenic mechanism for this type of epilepsy, we screened and functionally tested other epileptogenic Nav1.1 mutants, found in families with high phenotypic variability. We performed the functional characterization with whole cell voltage clamp recordings of tsA-201 cells transfected with the mutant channel. To date, we have found three potential new folding defective mutants. We obtained partial or almost complete rescue of these mutants by incubation at lower temperature and by incubation with pharmacological chaperones or with interacting proteins. The identified mutations are localized in different domains of the channel. Thus, mutations causing folding defects are not restricted to the C-terminal intracellular domain and may be common in Nav1.1 related epilepsies.

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Orlandi, Luigi. "Sindrome di Brugada: caratterizzazione mediante voltage-clamp delle mutazioni dei canali del sodio." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25174/.

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La Sindrome di Brugada è una patologia cardiaca descritta nel 1992 dai fratelli Brugada che si associa a un rischio aumentato di morte improvvisa in assenza di una cardiopatia strutturale. L'incidenza di eventi letali è più elevata nei maschi nella terza e quarta decade di vita. È una patologia genetica che colpisce alcuni canali ionici, strutture poste sulla superficie delle cellule del cuore, causandone un malfunzionamento e creando così degli squilibri nell’attività elettrica aumentando il rischio di insorgenza di aritmie ventricolari potenzialmente fatali. Tipicamente gli uomini manifestano la malattia più frequentemente delle donne; essa ha una prevalenza stimata di 5 su 10.000 e una trasmissione autosomica dominante; pertanto, la probabilità di trasmettere la patologia è del 50% a ogni gravidanza. Data l’origine genetica della sindrome, indagare la storia familiare è molto importante. I pazienti con sindrome di Brugada possono avere storia familiare positiva per morte improvvisa in età giovanile (cioè un’età inferiore ai 50 anni) per cause non note, familiari a cui è stata posta diagnosi di epilessia (non per una associazione tra le due malattie, ma per la possibile confusione tra episodi epilettici e sincopi aritmiche) oppure storia di aborti tardivi in famiglia. Nel lavoro tratterò delle caratterizzazioni in vitro dell’elettrofisiologia di correnti ioniche differenti, a seconda del tipo di mutazione riscontrata; parlerò di misurazioni effettuate con il Voltage-Clamp, tecnica utilizzata per misurare le correnti di ioni attraverso la membrana di cellule eccitabili, mantenendo la differenza di potenziale tra l’interno e l’esterno della membrana ad un potenziale di Holding (potenziale di partenza definito). Queste misurazioni vengono effettuate su cellule in cui si fa esprimere il gene che esprime il fenotipo normale, chiamate cellule wild-type (o eterologhe), e su cellule in cui viene espresso il gene con la mutazione nota.

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Godoy, Carlos Marcelo Gurjão. "Estudo da modulação do canal de sodio pela ativação da proteina quinase." [s.n.], 1994. http://repositorio.unicamp.br/jspui/handle/REPOSIP/260431.

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Анотація:

Orientadores: Jose Wilson Magalhães Bassani e Samuel Cukierman
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica
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Resumo: Os canais de sódio são responsáveis pela geração da atividade elétrica celular associada a funções específicas, tais como a contração das células cardíacas que promove o batimento cardíaco, ou transmissão de sinais de controle para todo o corpo pelas fibras nervosas. Os canais de sódio podem ser modulados por inúmeros mecanismos celulares, inclusive pela fosforilação (ligação de íon fosfato), por proteína quinases, da proteína que o constitui. A proteína quinase C, ativada pelo aumento intracelular de diacilglicerol em resposta à estimulação alfa-adrenérgica ou colinérgica muscarínica, pode fosforilar o canal de sódio. Neste trabalho, estudamos os efeitos de três diferentes classes de ativadores da proteína quinase C (diacilglicer6is, ácidos graxos insaturados-cis e ésteres de forbol) sobre a função do canal de sódio e propomos um mecanismobiofísico pelo qual uma das classes de ativadores (os diacilgliceróis) modula o canal de sódio. Utilizamos duas técnicas de "patch clamp" para registro de corrente de sódio em células de neuroblastoma de camundongo (NIE-115): i) "perforatedpatch clamp" para registro de correntesmacroscópicasde sódio e, ii) "cellattached patch clamp" para registro de corrente em canais de sódio.individuais ("single channel recording"). Os resultados obtidos revelaram que os ativadores da proteína quinase C tem múltiplos efeitos sobre as correntes de sódio. Isto sugeriu a existencia de mais de um mecanismo de modulação do canal de sódio pela ativação da proteína quinase C. A ativação da proteína quinase C por diacilglicerol diminuiu as correntes de sódio e desviou a curva de inativação para potenciais mais negativos. A partir de um modelo biofísico baseado nas transições de estado do canal, e de resultados experimentais que confirmaram as previsõesdo modelo,propusemosque o mecanismo pelo qual os diacilgliceróis modulam o canal de sódio consiste do aumento no número de canais que inativam-se diretamente a partir de seu estado de repouso. Este efeito dos diacilgliceróis é um mecanismo biofísico simples e eficiente pelo qual a ativação da proteína quinase C pode modular a função do canal de sódio e, conseqüentemente,a excitabilidade elétrica celular
Abstract: Sodium channels are responsible for the generation of cellular electrical activity involved in specific functions, such as cardiac cell contraction for heart beating, or electrical signal transmission performed by nerve cells for the whole body control. Sodium channels are modulated by many cell mechanisms, incIuding phosphorylation(phosphate ion bonding) of the channelprotein by protein kinases. Protein kinaseC, which is activated when intracellulardiacylglicerolconcentrationis increasedby alpha -adrenergic or cholinergic stimulation,is known to be a sodium channel phosforylator. In this work, we have studied the effects of three different protein kinase C activators (diacylglicerols, cis-unsaturated fatty acids and forbol esters) on sodium channel and suggested a biophysical mechanism for modulation by one kind of the protein kinase C activator (the diacylglicerols). We have used two patch clamp techniques for the sodium current recording in mouse neuroblastoma cells (NIE- 115): i) perforated patch clamp for macroscopic sodium currents recording and li) cellattached patch clamp for single channel recording. The results showed that protein kinase C activators have multiple effects on sodium currents. These results suggested that protein kinase C activation modulates the sodium channel by more. than one mechanism. Protein quinase C activation by diacylglicerol decreased the sodium current amplitude and shifted the inactivation curve to more negative voltages. Considering a biophysical model based on state transitions of the sodium channel and the experimental results that confmned the model predictions, we proposed that the mechanism by which the diacylglicerols modulate sodium channel is an increase on the number of sodium channels direct1y inactivating from their resting state. This diacylglicerol effect represents a simple and efficient biophysical mechanism by which protein kinase C activation might modulate sodium channel function and consequent1y, the cell electrical activity
Doutorado
Engenharia Biomedica
Doutor em Engenharia Elétrica

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Fraceto, Leonardo Fernandes. "Anestesicos locais : interação com membranas e fragmento do canal de sodio voltagem dependente." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314704.

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Анотація:

Orientadores: Thelma de Aguiar Pertinhez, Eneida de Paula
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Doutorado

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Díaz, Ubilla Macarena Francisca. "Tráfico de los canales de sodio activados por voltaje hacia la membrana axonal en un modelo de daño de nervio ciático." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/170127.

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Memoria para optar al título de Bioquímico
Las neuronas son células que permiten la conducción nerviosa mediante potenciales de acción. Para lograr esto, evolucionaron y desarrollaron una proyección altamente especializada llamada axón, en la cual se concentran canales iónicos de membrana que permiten el flujo de iones. Los canales de sodio activados por voltaje (Nav) son los canales iónicos que permiten la generación y propagación de los potenciales de acción. En el caso de los axones mielinizados, estos se concentran en el segmento inicial del axón y en los nodos de Ranvier, constricciones simétricas de la vaina de mielina donde se regenera el potencial de acción. Su abundancia y distribución a lo largo del axón no son fijas, sino que varían durante procesos como desarrollo y regeneración axonal. Se sabe que los axones son capaces de sintetizar proteínas localmente. A la fecha se ha reportado que la síntesis axonal de proteínas se ve aumentada en respuesta a daño axonal. Sin embargo, se desconoce si proteínas de membrana también son sintetizadas y traficadas localmente. En este contexto se ha reportado un aumento de Nav luego de daño axonal. El objetivo de este trabajo es establecer si la síntesis axonal de proteínas y la ruta secretoria local contribuyen a reestablecer los niveles de Nav en nodos de Ranvier luego de daño axonal. Para evaluar esto, se utilizó un modelo de daño axonal generado a partir de la transección de nervio ciático de rata. Se inhibió la síntesis y ruta secretoria axonal mediante la aplicación in vivo de cicloheximida (CHX) y brefeldina A (BFA) respectivamente. Ambos fármacos fueron inyectados independientemente en el nervio transectado. Se evaluó su efecto sobre la abundancia y distribución de Nav mediante inmunofluorescencia y western blot. En primer lugar, se corroboró que el daño axonal produce un aumento de los Nav en los nodos de Ranvier. Esta sobreexpresión de los canales de sodio activados por voltaje producto de daño axonal es bloqueada al inhibir la síntesis y ruta secretoria axonal con herramientas farmacológicas. Estos datos sugieren la existencia de una ruta biosintética y de tráfico axonal capaz de mediar el rápido aumento de Nav en procesos de regeneración axonal
Neurons are highly polarized cells that evolved to transmit nerve impulses. To achieve this function, they developed a process called the axon that concentrates ion channels. Voltage gated sodium channels (Nav) are responsible for generating and propagating action potentials. In myelinated axons, these proteins are concentrated at the axon initial segment (AIS) and at the nodes of Ranvier. Nodes are symmetric constrictions of the myelin sheath where action potentials are regenerated. The availability and distribution of Nav are plastic, meaning they change during developmental stages or regeneration. It is currently known that axonal protein synthesis in enhanced in response to axonal injury. However, it is still unknown whether local protein synthesis controls the abundance of membrane proteins in the axon and if Nav are subject to this regulation. The aim of this work is to study if Nav upregulation after axonal injury is related with axonal protein synthesis and the axonal secretory route. To evaluate this, we used an axonal injury model generated from the transection of the rat sciatic nerve. Local synthesis and the function of the axonal secretory route were inhibited in vivo using cycloheximide (CHX) or brefeldin A (BFA) respectively. Both drugs were injected in the nerve right after transection. The effect on Nav was evaluated by immunofluorescence and western blot. First, we corroborated that axonal injury enhances Nav at nodes of Ranvier. This upregulation disappears when axonal protein synthesis or the local secretory route were inhibited. Our data suggest the existence of an axonal synthetic and trafficking route capable of mediating the fast Nav upregulation during axonal regeneration
ICM, número de proyecto P09-015-F; Fondecyt, 1140617

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Martinez, Moreno Rebecca. "Effect of sodium channel SNVs associated to arrhythmogenic diseases. Modulatory role of the genetic background." Doctoral thesis, Universitat de Girona, 2021. http://hdl.handle.net/10803/672837.

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Ion channel mutations can cause defects on the electrical cellular activity, leading to arrhythmogenic diseases also known as channelopathies. Genetic analysis has been a useful tool to identify these mutations as the cause of different arrhythmogenic diseases. However, not all the members of the same family carrying a mutation present the same phenotype. This is known as incomplete penetrance. The results from this Thesis support that the incomplete penetrance of arrhythmogeic diseases is regulated by specific variants from each patient. Thus, a variant pathogenicity should be evaluated taking into account the presence of other genetic changes that could modulate its effect
Mutacions als canals iònics poden causar defectes en l’activitat elèctrica cel·lular, donant lloc a malalties aritmogèniques, també conegudes com canalopaties. Les anàlisis genètiques han sigut una eina útil per a identificar aquestes mutacions com la causa de diferents malalties aritmogèniques. Malgrat això, no tots els membres d’una família que tenen una mutació presenten la mateixa simptomatologia. Això es coneix com a penetrància incompleta. Els resultats d’aquesta Tesi recolzen que la penetrància incompleta de malalties aritmogèniques està regulada per variants específiques de cada pacient. Així doncs, la patogenicitat d’una variant hauria de ser avaluada tenint en compte la presència d’altres canvis genètics que puguin modular el seu efecte
Programa de Doctorat en Biologia Molecular, Biomedicina i Salut

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Cortada, Almar Èric. "Trafficking and function of the voltage-gated sodium channel β2 subunit". Doctoral thesis, Universitat de Girona, 2020. http://hdl.handle.net/10803/671239.

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The sodium channel β2 subunit is a component of the voltage-gated sodium channel (NaV), a large multimeric protein complex. In the heart, NaV is mainly composed of a pore-forming α subunit, NaV1.5, and two associated β subunits. Deficient NaV plasma membrane localization underlies a subset of channelopathies with high incidence in sudden death. The precise role of β2 in the NaV complex is still a mystery. However, there have been described mutations in β2 linked to Brugada Syndrome (BrS) and Atrial Fibrillation, both deadly cardiac arrhythmias. We explore the polarized trafficking of β2 and describe its function in promoting the localization of NaV1.5 to the apical domain of Madin-Darby canine kidney cells. Overall, our findings support the idea that β2 promotes the functional localization of NaV1.5 to specific subdomains of the plasma membrane, thereby ensuring enough sodium channel density and decreasing arrhythmogenic potential
La subunitat β2 és un component del canal de sodi dependent de voltatge (NaV), un complex proteic multimèric. Al cor està compost principalment per una subunitat α, formadora del porus, i dues subunitats β associades. Les fallides en la correcte localització de NaV són la base d’un conjunt de canalopaties amb alta incidència de mort sobtada. Es desconeix el paper que juga β2 al cor. Tot i això, s’han descrit mutacions en β2 associades a fibril·lació atrial i síndrome de Brugada. Explorem el tràfic polaritzat de β2 i descrivim la seva funció en promoure la localització de NaV1.5 al domini apical de cèl·lules Madin-Darby canine kidney. Els nostres resultat donen suport a la idea que β2 promou la localització funcional de NaV1.5 a subdominis específics de la membrana plasmàtica. D’aquesta manera, β2 assegura una densitat de canals de sodi suficient i disminueix el potencial arritmogènic

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Brugada, Ramon. "Genètica i caos elèctric. El canal de sodi en la síndrome de Brugada." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/4510.

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In this work we have investigated the Brugada syndrome caused by mutations in the sodium channel. We have performed clinical and genetic investigations to identify the genetic carriers. We have also investigated how the genetic background and the external modifiers modulate the disease phenotype. We have been able to prove that in Brugada syndrome the genetic testing is very valuable for two main reasons: first, because in a family with an identified mutation we are able to identify the non-carriers, and therefore those that are free of the disease. Secondly genetic testing allows the adoption of preventive measures in asymptomatic carriers, like the rapid treatment of fever or the avoidance of drugs that may block the sodium channel. Only for those two reasons it is justifiable the genetic analysis. Finally we have shown that neither the type of mutation, nor its localization in the protein allows us to estimate the risk of sudden death. In the asymptomatic individual with a normal ECG, the presence of a mutation is only indicative of a risk of developing the disease, but it is not a given that he will suffer from it. Despite the increase in genetic testing, at present its practice does not seem justified if only to define the therapeutic aggressiveness. The asymptomatic individuals who develop symptoms at follow-up present always clear clinical alterations, like a prolongation of the QT interval or elevation of the ST segment. These ecg parameters already define the need to perform additional tests or the adoption of preventive measures. In conclusion, being only a genetic carrier does not justify a more aggressive treatment at present. The treatment has to be determined by the result of the clinical tests.

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Johnson, Marc. "Les stratégies de l'acadianité : analyse socio-historique du rôle de la presse dans la formation de l'identité acadienne." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2A001.

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Ancienne colonie française aujourd'hui intégrée dans les provinces maritimes du Canada, l'Acadie peut être aujourd'hui considérée comme une société locale. Minoritaire, composée par le groupe ethnique acadien ayant le français comme langue d'usage. Inscrite dans un rapport de domination, de dépendance et d'aliénation interethnique, l'Acadie investit intensément son champ identitaire pour fonder son existence collective. La définition de l'acadianité, à partir d'un substrat socio-culturel accumulé depuis près de quatre siècles, et sa diffusion publique, constituent ainsi des enjeux importants. Elles font même l'objet de stratégies de la part des différents groupes sociaux qui cherchent à gagner ou maintenir une position d'influence au sein de cette société. Un appareil ethnique s'est mis en place depuis plus d'un siècle pour assurer ce travail de l'identité, par l'élaboration d'idéologies identitaires qui façonnent la mémoire collective et donnent un sens au quotidien. Les journaux acadiens sont parmi les plus performants des institutions qui composent cet appareil. L'analyse de leur arrière-plan institutionnel et de leur production de l'information acadienne révèle les stratégies identitaires dont ils ont été les instruments au cours du dernier siècle. Cette lecture socio-historique fait aussi la lumière sur le processus récent (depuis les années soixante) de transition de la traditionalité à la modernité acadienne, marquée par la présence accrue d'une régulation étatique de l'acadianité
Acadia, a former French colony now part of the maritime provinces of Canada, may be considered as a local society, a minority, comprising the Acadian ethnic group which is french-speaking. In order to establish its collective existence, given a context of interethnic domination, dependence and alienation, Acadia puts considerable effort in shaping its identity, consequently, high stakes are attached to defining acadianite (acadian-ness) on the basis of a sociocultural substratum, built up power almost four centuries, and disseminating this knowlegde to the public. This even becomes the object of strategies used by different social groups seeking to gain or maintain an influential position within that society. Over more than a century, an ethnic apparatus has evolved, which, by developing identity ideologies which shape the collective memory and give meaning for everyday life, ensures this process of identity creation. Acadian newspapers are amongst the most effective institutions within this apparatus. Analysis of their institutional background and of their production of Acadian information shows in which identity strategies they have been instrumental over the past century. This historical overview also sheds light on the recent transition (since the sixties) from traditionality to modernity in Acadia, characterized by increased state regulation of acadianite

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Gagnon, Jean-Pierre. "Le 22e bataillon (canadien-français), 1914-1919 : une étude socio-militaire." Doctoral thesis, Université Laval, 1986. http://hdl.handle.net/20.500.11794/29130.

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Книги з теми "Canali al sodio"

Dugas, Clermont. Disparités socio-économiques au Canada. Sillery, Québec: Presses de l'Université du Québec, 1988.

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Bloom, Michael R. Strengthening Canada: The socio-economic benefits of sport participation in Canada. Ottawa, ON: Conference Board of Canada, 2005.

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Belhadji, El Bachir A. Profil socio-économique des coopératives autochtones au Canada. Ottawa, Ont: Secrétariat aux coopératives, Gouvernement du Canada, 2001.

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Agri-Food, Canada Agriculture and. Socio-economic profile of aboriginal co-operatives in Canada. Ottawa: Co-operatives Secretariat, 2001.

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Belhadji, El Bachir A. Socio-economic profile of aboriginal co-operatives in Canada. [Ottawa]: Co-operatives Secretariat, Govt. of Canada, 2001.

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Dhesi, Autar S. Agro-economic,Socio-economic and Environmental Impact Study(Sirhind Feeder Canal). New Delhi: Central Water Commission, 1996.

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Harder, Sandra. Women in Canada: Socio-economic status and other contemporary issues. Ottawa, Ont: Library of Parliament, Research Branch, 1996.

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Corbett, Ron. Single parent families in Atlantic Canada: A socio-economic profile. Sackville, N.B: Rural and Small Town Research and Studies Programme, Dept. of Geography, Mount Allison University, 1987.

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Paul, Kariya, and University of Winnipeg. Institute of Urban Studies., eds. Native socio-economic development in Canada: Change, promise and innovation. Winnipeg: Institute of Urban Studies, University of Winnipeg, 1989.

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Canada. Library of Parliament. Current Issue Review. Women in Canada: socio-economic status and other contemporary issues. Ottawa: Library of Parliament, 1996.

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Частини книг з теми "Canali al sodio"

Toseef, Abdullah, Umar Burki, and Pervin Ersoy. "The socio-economic metabolism of Canada." In Foundations of a Sustainable Economy, 237–53. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003010579-16.

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Buckland, Jerry, and Brenda Spotton Visano. "Socio-Cultural and Economic Institutions at the Local Level." In Financial Vulnerability in Canada, 57–91. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92581-9_4.

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Vaughan, Geraldine. "Socio-National Anti-Catholicism." In Anti-Catholicism and British Identities in Britain, Canada and Australia, 1880s-1920s, 151–87. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-11228-7_5.

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Shrestha, Anushiya, Dik Roth, and Saroj Yakami. "From Royal Canal to Neglected Canal? Changing Use and Management of a Traditional Canal Irrigation System in Peri-Urban Kathmandu Valley." In Water Security, Conflict and Cooperation in Peri-Urban South Asia, 45–66. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79035-6_3.

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AbstractIn this chapter we discuss the changing uses and management of a traditional canal irrigation system against the background of processes of urbanization in Kathmandu Valley in Nepal. Until urbanization of Kathmandu Valley took off in the 1980s, the management of stream-fed canal irrigation systems had been a priority of both state agencies and the population that depended on agriculture-based livelihoods. The name rajkulo (royal canal) given to these systems expresses the historical interests of (royal) state actors in canal maintenance and management. Fed by a stream called Mahadev Khola in Dadhikot, a peri-urban village in Kathmandu Valley, Mahadev Khola Rajkulo is such a traditional canal irrigation system. Using an in-depth case study of this system, we analyse the interlinkages of demographic, socio-environmental, economic and local political dynamics with the changing canal uses and management. More specifically, we discuss how and why various actors became associated with, or dissociated from, canal use and management in recent times, and what these processes mean for water access, rights and security. We reflect on the implications of these changes for canal management and canal-related conflicts, against the background of national urban policies that formally aim to conserve agricultural land in Kathmandu Valley, but stimulate urban expansion in practice.

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Abban-Mensah, Isaac, Martijn Vis, and Peter van Sleen. "Socio-Economic Impacts of a Lignocellulosic Ethanol Refinery in Canada." In Socio-Economic Impacts of Bioenergy Production, 233–51. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03829-2_14.

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Goksel, Gulay Ugur. "Socio-economic Integration of Skilled Immigrants in Canada." In Integration of Immigrants and the Theory of Recognition, 105–44. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65843-8_4.

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Bowes-Lyon, Léa-Marie, Jeremy P. Richards, and Tara M. McGee. "Socio-Economic Impacts of the Nanisivik and Polaris Mines, Nunavut, Canada." In Mining, Society, and a Sustainable World, 371–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01103-0_13.

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Adams, Michael. "14. The October I 992 Canadian Constitutional Referendum: The Socio-Political Context." In The Charlottetown Accord, the Referendum, and the Future of Canada, edited by Kenneth McRoberts and Patrick J. Monahan, 185–92. Toronto: University of Toronto Press, 1993. http://dx.doi.org/10.3138/9781487577681-016.

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Buckland, Jerry. "A Socio-economic Examination of Payday Loan Clients: Why and How People Use Payday Loans." In Payday Lending in Canada in a Global Context, 65–81. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71213-0_3.

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Thunert, Martin. "The Canadian Charter of Rights and Freedoms: Product and Catalyst of Socio-Political Change in Canada." In The Politics of Constitutional Reform in North America, 255–72. Wiesbaden: VS Verlag für Sozialwissenschaften, 2000. http://dx.doi.org/10.1007/978-3-663-11628-8_13.

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Тези доповідей конференцій з теми "Canali al sodio"

Madhushan, A. M. L., and J. Dharmasena. "A STUDY ON QUALITY OF LIFE OF MIDDLE-INCOME GROUP ALONG URBAN CANAL WATERFRONTS." In Beyond sustainability reflections across spaces. Faculty of Architecture Research Unit, 2021. http://dx.doi.org/10.31705/faru.2021.13.

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In most of the cases, canal network in Greater Colombo region work as the drainage system of the urban area and as the backyard of the city. Therefore, there is a lack of attention to the canal waterfronts by the government and by the public. Hence, this research was to find out and evaluate the factors, which will affect the quality of life of people along urban canal waterfronts. It has been discussed in terms of liveability through a series of carefully selected indicators. Liveability surveys were conducted along five canal waterfronts and the participants’ perceptions were taken. Every canal waterfront was assigned a rating of over 25 qualitative and quantitative factors (set of indicators) across six broad categories (dimensions): safety, comfort, health and wellbeing, mobility, environment, and socio-cultural factors. Each qualitative factor was given a rating from 1(tolerable)-5(intolerable). Qualitative factors were then combined with quantitative factors through a series of equations to form the liveability index. According to the proposed liveability index, transport dimension index is ideal (100), while the health and well-being dimension is the lowest (27). This will help for the creation of government policies, plans, rules and regulations and when implementing projects along urban canal waterfronts.

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Akberdieva, D. F. "SOCIO-PSYCHOLOGICAL ASPECTS IN PROFESSIONAL TRAINING OF BACHELORS FOR THE TOURISM AND HOSPITALITY INDUSTRY." In VIII International Conference "Science and Society - Methods and Problems of Practical Application". Prague: Premier Publishing s.r.o., 2019. http://dx.doi.org/10.29013/viii-conf-canada-viii-44-46.

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Dowse, Susan, Meaghan Hoyle, and Katherine Card. "Socio-Economic Effects Monitoring and Pipelines: Moving Towards a Practical and Project-Specific Framework." In 2016 11th International Pipeline Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/ipc2016-64607.

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Socio-economic effects monitoring is emerging as a regulatory requirement and risk management tool in the Canadian pipeline sector. While socio-economic impact assessments have been part of the regulatory landscape for some time, the additional step of socio-economic monitoring beyond the predictions of the assessment, in a parallel fashion with environmental monitoring, has not. Generally, socioeconomic monitoring is a process to track project-related socioeconomic outcomes, to evaluate the effectiveness of mitigation that was designed during the regulatory assessment phase, and to adapt or improve mitigation in order to respond to unanticipated outcomes. Different from mines or industrial facilities that are focused in one geographic area with a long term operating presence, pipelines present unique challenges with respect to socio-economic monitoring. Monitoring of pipeline projects requires an approach that considers the interests of often numerous administrative and geographic jurisdictions and the challenge of data collection over a relatively short-term construction period. These pipeline-specific factors are layered with the challenges associated with all socio-economic monitoring programs related to multiple influences on social and economic outcomes and the challenge of effect attribution. This paper provides an overview of socio-economic monitoring as a requirement in the Canadian pipeline context, and reviews the public domain approaches proposed by various recent project proponents in Canada. This paper ultimately presents a framework for a practical and focused socio-economic monitoring process that is uniquely suitable for the context of major pipeline projects (Pipeline Socio-Economic Monitoring — or P-SEM — Model). The P-SEM model will help Project Managers meet regulatory requirements, improve mitigation, buffer projects from broader socio-economic issues that are beyond their sole control, and create a touch point for engagement with project stakeholders through pipeline construction.

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Wang, Liang. "Health state valuation and its socio-economic factors: online samples from the U.S. and Canada." In The 3rd International Electronic Conference on Environmental Research and Public Health —Public Health Issues in the Context of the COVID-19 Pandemic. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecerph-3-09000.

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Zinoveva, Irina, and K. Osipova. "CORPORATE TAXATION IN THE COUNTRIES OF THE WORLD." In Manager of the Year. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2022. http://dx.doi.org/10.34220/my2021_55-59.

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The article is devoted to the consideration of the issue of corporate taxation in the countries of the world with favorable and optimal conditions of the tax system (USA, Thailand, Canada, Germany, Russia). Within the framework of this work, the features of collecting and dynamics of the corporate tax rate, types and elements of taxation are determined. According to the results of the study, the leading role of the state in the development and implementation of tax policy within the framework of the implemented strategy of socio-economic development of the country is concluded.

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Oyediji, Remi, and Susan Tighe. "Impacts Of Flooding On Concrete Pavement." In 12th International Conference on Concrete Pavements. International Society for Concrete Pavements, 2021. http://dx.doi.org/10.33593/5se85bna.

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With shifting paradigms in usual climatic events and increased occurrence of flood hazards, vulnerability assessment and adaptation of road infrastructure is essential. Road pavements are critical in sustaining socio-economic activities and their vulnerability to flood hazards could have serious cost consequences. Therefore, a conscientious decision to consider pavement materials, designs and alternatives that are resilient to recurring flood events is desired. Based on previous investigations into how pavements types, classes and configuration respond to extreme events, concrete pavements are reported as better flood-resilient systems in countries that have experienced intense flooding and inundation. Although Canada has experienced some of the worst flood incidences in history and owns a number of concrete pavement infrastructure, no study has been conducted to better understand its performance under extreme conditions. To provide insight on concrete pavement flood response, the use of the state of the art AASHTOWare Pavement ME Design (PMED) program is employed to model various flood scenarios on concrete pavement types and configurations common to two Canadian provinces, Ontario and Manitoba. The performance of the various pavement classes in terms of flood resilience, service life and cost feasibility is analyzed and results provide insight on the resilience and adaptive capacity of rigid pavements to flood hazards in Canada.

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Titus, Raylene Rozita, and Johannes John-Langba. "P107 Socio-cultural factors influencing condom use intentions among African migrant youth in South Africa." In Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14–17, 2019, Vancouver, Canada. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/sextrans-2019-sti.295.

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Samuels, Linda C., and Bernardo Teran. "Infrastructural OpportunismI-11_A Next Generation Infrastructure Case Study." In 2017 ACSA Annual Conference. ACSA Press, 2017. http://dx.doi.org/10.35483/acsa.amp.105.7.

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Federal transportation legislation known as MAP-21 brought renewed attention to a proposed interstate corridor (I-11) connectingLas Vegas and Southern Arizona to complete a new Canada to Mexico, or CANAMEX, corridor. Using I-11 as a case study, our studio explored three key ways otherwise status quo infrastructure can be transformed into innovative, sustainable solutions: by intervening in the design and planning process, by transforming the existing mono-functional freeway prototype, and by evolving the freeway paradigm from an “engineering only”to a “sustainability first” model. Students and faculty from architecture, planning and landscape architecture investigated the possibilities of transforming the proposed I-11freeway from a limited use, auto-dominant roadway (the “red arrow” scenario) into a sustainable, multi-functional, ecologically and socio-economically focused Super corridor (the“green arrow” scenario). The results of this work, summed up on this poster, exhibit the advantages of infrastructure opportunism –leveraging investments intended for status quo infrastructure towards more broadly inclusive, design-centric, next generation proposals.

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Sharma, Sarbjeet, Gagandeep Singh, and Nikhil Sharma. "P115 Socio-demographic profile of HIV seropositivity in a tertiary care north indian hospital: a ten year retrospective study." In Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14–17, 2019, Vancouver, Canada. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/sextrans-2019-sti.298.

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Buszynski, Mario E., and Tanya Peacock. "The Environmental and Socio-Economic Impacts and Benefits Associated With Developing a Natural Gas Distribution System in Nova Scotia." In 2000 3rd International Pipeline Conference. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/ipc2000-141.

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Novia Scotia, a province of about one million people, is located on the east coast of Canada. With the discovery of large natural gas reserves off the Scotian Shelf, offshore production platforms, undersea and onshore pipelines have been constructed to link the find with major markets in Boston by the end of 1999. The onshore pipeline through the province will allow a distribution system to be developed. This natural gas system will be the largest Greenfield development seen in North America for many years. A billion-dollar expenditure is proposed to establish a local distribution company, which would construct and maintain around 8,000 kilometres of distribution and lateral pipelines in the province. An integral part of this program involves the provision of local benefits through hiring and purchasing of goods and services. This paper describes aspects of the construction program and benefits plan proposed during the regulatory hearings in order to illustrate the methods used to ensure that the objectives of accessing the majority of Nova Scotians in a seven year planning horizon will be met. The varied landscapes to be crossed and specialized construction techniques to meet those challenges are discussed. The mechanisms in place to ensure maximum benefit for Nova Scotians are also discussed. Up-to-date information will be presented to demonstrate how the benefits plan is being implemented. The successes of the benefits plan for the distribution utility and the other local megaproject in the province (Sable Offshore Energy) are compared. Conclusions will be drawn regarding successful strategies for implementing benefits plans related to large energy projects.

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Звіти організацій з теми "Canali al sodio"

Clavet, Nicholas-James, Mayssun El-Attar, and Raquel Fonseca. Replacement rates of public pensions in canada: heterogeneity across socio-economic status. CIRANO, April 2022. http://dx.doi.org/10.54932/xcoz6579.

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When individuals decide to retire from the labour force, different sources of income can help to maintain consumption and welfare. One of those is public pensions. Their importance as an income source varies greatly according to socio-economic status (SES). This paper analyzes how replacement rates (RR) of public pensions (OAS and GIS) and mandatory public pension benefits (C/QPP) vary across SES by using the Longitudinal and International Study of Adults dataset (LISA). Using the longitudinal nature of this survey, we compute and compare average RRs by SES. We specifically consider the role of education and health, and we study how living arrangements can explain RRs variations. To give an idea the average RR of public pensions for individuals in bad health is 32%, while it is 21% for those who report being in good health. Including public pensions and C/QPP benefits, these numbers become 54% for those in bad health and 41% for those in good health. When estimating a multivariate regression model and controlling for past income, we find for couples, that past income does not eliminate differences in replacement ratio by individuals’ characteristics. We argue that assortative mating plays a role in explaining the variation of replacement rates across individuals’ characteristics.

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Huntley, D., D. Rotheram-Clarke, R. Cocking, J. Joseph, and P. Bobrowsky. Understanding plateau and prairie landslides: annual report on landslide research in the Thompson River valley, British Columbia, and the Assiniboine River valley, Manitoba-Saskatchewan (2020-2021 to 2021-2022). Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/329205.

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Open File 8838 is a publication of Interdepartmental Memorandum of Understanding (IMOU) 5170 between Natural Resources Canada (NRCAN), the Geological Survey of Canada (GSC), and Transport Canada Innovation Centre (TC-IC). IMOU 5107 aims to gain new insight into slow-moving landslides and the influence of climate changes through testing conventional and emerging monitoring technologies along strategically important sections of the national railway network in the Thompson River valley, British Columbia, and the Assiniboine River valley along the borders of Manitoba and Saskatchewan. The results of this research will be applicable to other sites in Canada, and elsewhere around the world where slowmoving landslides and climate change are adversely affecting critical socio-economic infrastructure.

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Buss, Doris, Blair Rutherford, Ekpedeme Edem, Sarah George, Cynthia Kumah, Michael Racioppo, Sarah Kinyanjui, and Aisha Ibrahim. Attending (to) class : An intersectional study of COVID-19 adaptation in Canada, Kenya and Sierra Leone Universities : Report on the Carleton University research. Carleton University Department of Law and Legal Studies, September 2021. http://dx.doi.org/10.22215/j.envsci.2021.09.30.

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This pilot study examines how intersecting differences – in gender, socio-economic status, rural/urban residences, and disability - shaped students’ experience of the shift to distance university education resulting from the COVID-19 pandemic and lockdowns in 2020-2021. Focused on three universities - Carleton University, (Ottawa, Canada), University of Nairobi, (Kenya, Mombasa campus), and University of Sierra Leone (Fourah Bay College, Freetown) - research teams based at each institution conducted surveys, interviews and focus groups with students to explore differences in students’ experience of remote learning.

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Geloso, Vincent, and Chandler S. Reilly. Did the ‘Quiet Revolution’ Really Change Anything? CIRANO, December 2022. http://dx.doi.org/10.54932/itzr4537.

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The year 1960 is often presented as a break year in the economic history of Quebec and Canada. It is used to mark the beginning of the “Quiet Revolution” during which Canada’s French-speaking province of Quebec under rapid socio-economic change in the form of rapid economic convergence with the rest of Canada and the emergence of a more expansive state. Using synthetic control methods, we analyze whether 1960 is associated with a departure from previous developments. With regards to GDP per capita, GDP per worker, household-size adjusted income, life expectancy at birth, and enrollment rates in primary and secondary schools, we find that 1960 was not an important date. For most of these measures, the counterfactual scenario is slightly better than the actual data but not by significant margins. Only with respect to the size of government do we find sign of a break.

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Bohuslavskyj, Oleh. UKRAINIAN-CANADIAN NEWSPAPER “NEW PATHWAY”: WINNIPEG PERIOD (1941-1977). Ivan Franko National University of Lviv, February 2022. http://dx.doi.org/10.30970/vjo.2022.51.11391.

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The subject of the study is the ideological, financial, economic and socio-social conditions of the publishing house and the editorial board of the magazine “New Pathway” Winnipeg period 1941-1977. The main objectives is to determine the peculiarities of the conditions of publishing a Ukrainian magazine in exile, which provides for the systematization and introduction into scientific circulation of factual material on creative and material activities of the “New Pathway” and socio-political environment that influenced the information and ideological and business policy of the publication. The basis of the research methodology is axiological, cultural, systemic approaches; methods of historicism, analysis, synthesis, generalization were used. The study provides not only a description of the historical path of the publication in this period, but also the reasons for miscalculations and successes, both financial and economic and socio-political, which allowed not only to stay in the information field and market for more than ninety years, technical circumstances of its existence, the political struggle in the new wave of emigration after World War II, changes in demographic and linguistic situation among the Ukrainian diaspora in Canada. The reasons for the situational increase and decrease in the activity of the publication’s subscribers were identified; the mechanisms of expanding the readership, attracting new readers and authors are analyzed; confirmed that the efforts of editors and directors of the publishing house at the initial stage of the Winnipeg period created and strengthened the material and technical base of the publishing house, conducted advertising campaigns and direct work to attract new subscribers and readers; The significance of the study is that for the first time in Ukraine the information about the Winnipeg period of the Ukrainian-Canadian weekly “New Pathway”, its financial and financial problems and creative and editorial successes was analyzed and summarized, thus filling another page in the history of Ukrainian diaspora periodicals.

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Huntley, D., D. Rotheram-Clarke, R. Cocking, J. Joseph, and P. Bobrowsky. Current research on slow-moving landslides in the Thompson River valley, British Columbia (IMOU 5170 annual report). Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/331175.

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Interdepartmental Memorandum of Understanding (IMOU) 5170 between Natural Resources Canada (NRCAN), the Geological Survey of Canada (GSC) and Transport Canada Innovation Centre (TC-IC) aims to gain new insight into slow-moving landslides, and the influence of climate change, through testing conventional and emerging monitoring technologies. IMOU 5107 focuses on strategically important sections of the national railway network in the Thompson River valley, British Columbia (BC), and the Assiniboine River valley along the borders of Manitoba (MN) and Saskatchewan (SK). Results of this research are applicable elsewhere in Canada (e.g., the urban-rural-industrial landscapes of the Okanagan Valley, BC), and around the world where slow-moving landslides and climate change are adversely affecting critical socio-economic infrastructure. Open File 8931 outlines landslide mapping and changedetection monitoring protocols based on the successes of IMOU 5170 and ICL-IPL Project 202 in BC. In this region, ice sheets, glaciers, permafrost, rivers and oceans, high relief, and biogeoclimatic characteristics contribute to produce distinctive rapid and slow-moving landslide assemblages that have the potential to impact railway infrastructure and operations. Bedrock and drift-covered slopes along the transportation corridors are prone to mass wasting when favourable conditions exist. In high-relief mountainous areas, rapidly moving landslides include rock and debris avalanches, rock and debris falls, debris flows and torrents, and lahars. In areas with moderate to low relief, rapid to slow mass movements include rockslides and slumps, debris or earth slides and slumps, and earth flows. Slow-moving landslides include rock glaciers, rock and soil creep, solifluction, and lateral spreads in bedrock and surficial deposits. Research efforts lead to a better understanding of how geological conditions, extreme weather events and climate change influence landslide activity along the national railway corridor. Combining field-based landslide investigation with multi-year geospatial and in-situ time-series monitoring leads to a more resilient railway national transportation network able to meet Canada's future socioeconomic needs, while ensuring protection of the environment and resource-based communities from landslides related to extreme weather events and climate change. InSAR only measures displacement in the east-west orientation, whereas UAV and RTK-GNSS change-detection surveys capture full displacement vectors. RTK-GNSS do not provide spatial coverage, whereas InSAR and UAV surveys do. In addition, InSAR and UAV photogrammetry cannot map underwater, whereas boat-mounted bathymetric surveys reveal information on channel morphology and riverbed composition. Remote sensing datasets, consolidated in a geographic information system, capture the spatial relationships between landslide distribution and specific terrain features, at-risk infrastructure, and the environmental conditions expected to correlate with landslide incidence and magnitude. Reliable real-time monitoring solutions for critical railway infrastructure (e.g., ballast, tracks, retaining walls, tunnels, and bridges) able to withstand the harsh environmental conditions of Canada are highlighted. The provision of fundamental geoscience and baseline geospatial monitoring allows stakeholders to develop robust risk tolerance, remediation, and mitigation strategies to maintain the resilience and accessibility of critical transportation infrastructure, while also protecting the natural environment, community stakeholders, and Canadian economy. We propose a best-practice solution involving three levels of investigation to describe the form and function of the wide range of rapid and slow-moving landslides occurring across Canada that is also applicable elsewhere. Research activities for 2022 to 2025 are presented by way of conclusion.

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Fang, Mei Lan, Marianne Cranwell, Becky White, Gavin Wylie, Karen Lok Yi Wong, Kevin Harter, Lois Cosgrave, et al. Aging-in-Place at the End-of-Life in Community and Residential Care Contexts. University of Dundee, January 2023. http://dx.doi.org/10.20933/100001274.

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Population aging is a global phenomenon that has presented capacity and resource challenges for providing supportive care environments for older people in later life (Bone et al., 2018, Finucane et al., 2019). Aging-in-place was introduced as a policy driver for creating supportive environmental and social care to enable individuals to live independently at home and in the community for as long as possible. Recently, there has been a move towards offering care for people with a terminal illness at home and in the community (Shepperd et al., 2016); and when appropriate, to die in supportive, home-like environments such as care homes (Wada et al., 2020). Aging-in-place principles can, thus and, should be extended to enabling supportive, home-like environments at the end-of-life. Yet, first, we must consider the appropriateness, availability and diversity of options for community-based palliative and end-of-life care (PEoLC), in order to optimise supports for older people who are dying at home or within long-term/residential care environments. Globally, across places with similar health and social care systems and service models such as in Scotland and in Canada, community-based PEoLC options are currently not uniformly available. Given that people entering into long-term/residential care homes are increasingly closer to the end of life, there is now an even greater demand for PEoLC provision in residential facilities (Kinley et al., 2017). Although most reported deaths occur within an inpatient hospital setting (50%), the proportion of overall deaths in a care home setting is projected to increase from 18% to 22.5% (Finucane et al, 2019). This suggests that long-term/residential care homes are to become the most common place of death by 2040, evidencing the need to develop and sustain appropriate and compassionate PEoLC to support those who are able to die at home and those living in residential care facilities (Bone et al., 2018; Finucane et al., 2019). This research initiative is premised on the notion that aging in place matters throughout the life-course, including at the end-of-life and that the socio-environmental aspects of care homes need to enable this.

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