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Статті в журналах з теми "Breath analysi"

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Vitalis, Timothy Z., and William K. Milsom. "Mechanical Analysis of Spontaneous Breathing in the Semi-Aquatic Turtle, Pseudemys Scripta." Journal of Experimental Biology 125, no. 1 (September 1, 1986): 157–71. http://dx.doi.org/10.1242/jeb.125.1.157.

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The normal breathing pattern of Pseudemys scripta (Schoepff) consists of a continuous burst of breaths separated by a variable period of breath holding. Under normoxic conditions, tidal volume was 6.9 ml kg−1 and the number of breaths was 1.9 min−1. Increases in pulmonary ventilation upon stimulation by hypercapnia (3% CO2) or hypoxia (4% O2) are caused primarily by increases in the number of breaths per minute due to a shortening of the breath-hold period. Tidal volume and breath duration remain unchanged. The instantaneous breathing frequency (f' = 60/Ttot) of 35 ± 2min−1 corresponds to continuous pump frequencies that minimize the rate of the mechanical work of breathing in anaesthetized turtles. This indicates that turtles breathe at a combination of tidal volume and f' that minimizes the power required to ventilate the lungs. To increase ventilation, the breath hold is shortened and more breaths are taken at this optimal combination. Bilateral vagotomy drastically alters the breathing pattern, producing an elevation in tidal volume, a slowing of breathing frequency, and a prolongation of breath duration while total ventilation remains unchanged. These data suggest that periodic breathing in this species may represent an adaptive strategy which is under vagal control and which serves to minimize the cost of breathing.
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Bukreyeva, Ye B., A. A. Bulanova, and Yu V. Kistenev. "APPLYING OF GAS ANALYSIS IN DIAGNOSIS OF BRONCHOPULMONARY DISEASES." Bulletin of Siberian Medicine 13, no. 5 (October 28, 2014): 122–29. http://dx.doi.org/10.20538/1682-0363-2014-5-122-129.

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Bronchopulmonary system diseases are on the first place among the causes of people's death. Most of methods for lung diseases diagnosis are invasive or not suitable for children and patients with severe disease. One of the promising methods of clinical diagnosis and disease activity monitoring of bronchopulmonary system is analyzing of human breath. Directly exhaled breath or exhaled breath condensate are using for human breaths analyzing. Analysis of human breath can apply for diagnostic, long monitoring and evaluation of efficacy of the treatment bronchopulmonary diseases. Differential diagnostic between chronic obstructive lung disease (COPD) and bronchial asthma is complicated because they have differences in pathogenesis. Analysis of human breath allows to explore features of COPD and bronchial asthma and to improve differential diagnostic of these diseases. Human breaths analyzing can apply for diagnostic dangerous diseases, such as tuberculosis, lung cancer. The analysis of breath air by spectroscopy methods is new noninvasive way for diagnosis of bronchopulmonary diseases.
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Oestreich, Marc-Alexander, Florian Wyler, Bettina S. Frauchiger, Philipp Latzin, and Kathryn A. Ramsey. "Breath detection algorithms affect multiple-breath washout outcomes in pre-school and school age children." PLOS ONE 17, no. 10 (October 14, 2022): e0275866. http://dx.doi.org/10.1371/journal.pone.0275866.

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Background Accurate breath detection is essential for the computation of outcomes in the multiple-breath washout (MBW) technique. This is particularly important in young children, where irregular breathing is common, and the designation of inspirations and expirations can be challenging. Aim To investigate differences between a commercial and a novel breath-detection algorithm and to characterize effects on MBW outcomes in children. Methods We replicated the signal processing and algorithms used in Spiroware software (v3.3.1, Eco Medics AG). We developed a novel breath detection algorithm (custom) and compared it to Spiroware using 2,455 nitrogen (N2) and 325 sulfur hexafluoride (SF6) trials collected in infants, children, and adolescents. Results In 83% of N2 and 32% of SF6 trials, the Spiroware breath detection algorithm rejected breaths and did not use them for the calculation of MBW outcomes. Our custom breath detection algorithm determines inspirations and expirations based on flow reversal and corresponding CO2 elevations, and uses all breaths for data analysis. In trials with regular tidal breathing, there were no differences in outcomes between algorithms. However, in 10% of pre-school children tests the number of breaths detected differed by more than 10% and the commercial algorithm underestimated the lung clearance index by up to 21%. Conclusion Accurate breath detection is challenging in young children. As the MBW technique relies on the cumulative analysis of all washout breaths, the rejection of breaths should be limited. We provide an improved algorithm that accurately detects breaths based on both flow reversal and CO2 concentration.
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Ashe, William B., Sarah E. Innis, Julia N. Shanno, Camille J. Hochheimer, Ronald D. Williams, Sarah J. Ratcliffe, J. Randall Moorman, and Shrirang M. Gadrey. "Analysis of respiratory kinematics: a method to characterize breaths from motion signals." Physiological Measurement 43, no. 1 (January 28, 2022): 015007. http://dx.doi.org/10.1088/1361-6579/ac4d1a.

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Abstract Objective. Breathing motion (respiratory kinematics) can be characterized by the interval and depth of each breath, and by magnitude-synchrony relationships between locations. Such characteristics and their breath-by-breath variability might be useful indicators of respiratory health. To enable breath-by-breath characterization of respiratory kinematics, we developed a method to detect breaths using motion sensors. Approach. In 34 volunteers who underwent maximal exercise testing, we used 8 motion sensors to record upper rib, lower rib and abdominal kinematics at 3 exercise stages (rest, lactate threshold and exhaustion). We recorded volumetric air flow signals using clinical exercise laboratory equipment and synchronized them with kinematic signals. Using instantaneous phase landmarks from the analytic representation of kinematic and flow signals, we identified individual breaths and derived respiratory rate (RR) signals at 1 Hz. To evaluate the fidelity of kinematics-derived RR, we calculated bias, limits of agreement, and cross-correlation coefficients (CCC) relative to flow-derived RR. To identify coupling between kinematics and flow, we calculated the Shannon entropy of the relative frequency with which flow landmarks were distributed over the phase of the kinematic cycle. Main Results. We found good agreement in the kinematics-derived and flow-derived RR signals [bias (95% limit of agreement) = 0.1 (± 7) breaths/minute; CCC median (IQR) = 0.80 (0.48–0.91)]. In individual signals, kinematics and flow were well-coupled (entropy 0.9–1.4 across sensors), but the relationship varied within (by exercise stage) and between individuals. The final result was that the flow landmarks did not consistently localize to any particular phase of the kinematic signals (entropy 2.2–3.0 across sensors). Significance. The Analysis of Respiratory Kinematics method can yield highly resolved respiratory rate signals by separating individual breaths. This method will facilitate characterization of clinically significant breathing motion patterns on a breath-by-breath basis. The relationship between respiratory kinematics and flow is much more complex than expected, varying between and within individuals.
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Wickham, P. J., and D. W. Walker. "Analysis of fetal breathing in real time using a microprocessor." Journal of Applied Physiology 62, no. 4 (April 1, 1987): 1733–39. http://dx.doi.org/10.1152/jappl.1987.62.4.1733.

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A system has been designed using an inexpensive microprocessor to analyze fetal breathing movements on a breath-by-breath basis in real time. An algorithm was developed which would recognize fetal breathing from the changes in tracheal pressure and which was capable of rejecting the artifactual changes caused by fetal or maternal movements. The tracheal pressure signal was digitized (at 51 samples/s), differentiated, and the start and peak of each breath was recognized from the zero-crossing points of the differentiated signal. Each breath was validated for size and shape according to a set of criteria incorporated into the breath recognition algorithm. On acceptance of the pressure change as a valid breath, the inspiratory time, breath amplitude, breath-to-breath interval, and inspiratory effort were calculated and stored in memory. The program was structured so that the microprocessor was able to accept new data and output summarizes of previous data concurrently. More than 95% of breaths in records contaminated with movement artifacts were recognized.
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Proctor, David N., and Kenneth C. Beck. "Delay time adjustments to minimize errors in breath-by-breath measurement of V˙o 2 during exercise." Journal of Applied Physiology 81, no. 6 (December 1, 1996): 2495–99. http://dx.doi.org/10.1152/jappl.1996.81.6.2495.

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Proctor, David N., and Kenneth C. Beck. Delay time adjustments to minimize errors in breath-by-breath measurement ofV˙o 2 during exercise. J. Appl. Physiol. 81(6): 2495–2499, 1996.—If the delay time between gas concentration and flow signals is not adequately corrected during breath-by-breath analysis of expired gas, an error in calculation of oxygen consumption (V˙o 2) will result. To examine the frequency and delay time dependences of errors inV˙o 2 measurement, six healthy men exercised at 100, 200, and 250 W on a cycle ergometer while breath-by-breath assessment ofV˙o 2 was made simultaneously with collection of expired air. Subjects breathed first at normal rates (15–30 breaths/min) and then at 70 breaths/min. Each subject performed each level of exercise twice by using erroneous values for the delay time between gas concentration and flow signals. At normal breathing frequencies, errors inV˙o 2 measurement were ±10% over the full range of delay times used, and the errors were not tightly correlated with variations in delay times from optimum. However, at 70 breaths/min, errors approached ±30% as the variations in delay times deviated ±0.1 s from the optimal, and the errors were highly correlated with the variations in delay times. We conclude that there is greater potential for errors inV˙o 2 measurement with incorrect delay time at higher breathing frequencies. These findings suggest that the optimal delay time for breath-by-breath systems should be adjusted by using high breathing frequencies.
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Fadel, Paul J., Susan M. Barman, Shaun W. Phillips, and Gerard L. Gebber. "Fractal fluctuations in human respiration." Journal of Applied Physiology 97, no. 6 (December 2004): 2056–64. http://dx.doi.org/10.1152/japplphysiol.00657.2004.

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The present study was designed to characterize respiratory fluctuations in awake, healthy adult humans under resting conditions. For this purpose, we recorded respiratory movements with a strain-gauge pneumograph in 20 subjects. We then used Allan factor, Fano factor, and dispersional analysis to test whether the fluctuations in the number of breaths, respiratory period, and breath amplitude were fractal (i.e., time-scale-invariant) or random in occurrence. Specifically, we measured the slopes of the power laws in the Allan factor, Fano factor, and dispersional analysis curves for original time series and compared these with the slopes of the curves for surrogates (randomized data sets). In addition, the Hurst exponent was calculated from the slope of the power law in the Allan factor curve to determine whether the long-range correlations among the fluctuations in breath number were positively or negatively correlated. The results can be summarized as follows. Fluctuations in all three parameters were fractal in nine subjects. There were four subjects in whom only the fluctuations in number of breaths and breath amplitude were fractal, three subjects in whom only the fluctuations in number of breaths were fractal, and two subjects in whom only fluctuations in breath number and respiratory period were fractal. Time-scale-invariant behavior was absent in the two remaining subjects. The results indicate that, in most cases, apparently random fluctuations in respiratory pattern are, in fact, correlated over more than one time scale. Moreover, the data suggest that fractal fluctuations in breath number, respiratory period, and breath amplitude are controlled by separate processes.
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Massaroni, Carlo, Daniel Simões Lopes, Daniela Lo Presti, Emiliano Schena, and Sergio Silvestri. "Contactless Monitoring of Breathing Patterns and Respiratory Rate at the Pit of the Neck: A Single Camera Approach." Journal of Sensors 2018 (September 23, 2018): 1–13. http://dx.doi.org/10.1155/2018/4567213.

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Vital signs monitoring is pivotal not only in clinical settings but also in home environments. Remote monitoring devices, systems, and services are emerging as tracking vital signs must be performed on a daily basis. Different types of sensors can be used to monitor breathing patterns and respiratory rate. However, the latter remains the least measured vital sign in several scenarios due to the intrusiveness of most adopted sensors. In this paper, we propose an inexpensive, off-the-shelf, and contactless measuring system for respiration signals taking as region of interest the pit of the neck. The system analyses video recorded by a single RGB camera and extracts the respiratory pattern from intensity variations of reflected light at the level of the collar bones and above the sternum. Breath-by-breath respiratory rate is then estimated from the processed breathing pattern. In addition, the effect of image resolution on monitoring breathing patterns and respiratory rate has been investigated. The proposed system was tested on twelve healthy volunteers (males and females) during quiet breathing at different sensor resolution (i.e., HD 720, PAL, WVGA, VGA, SVGA, and NTSC). Signals collected with the proposed system have been compared against a reference signal in both the frequency domain and time domain. By using the HD 720 resolution, frequency domain analysis showed perfect agreement between average breathing frequency values gathered by the proposed measuring system and reference instrument. An average mean absolute error (MAE) of 0.55 breaths/min was assessed in breath-by-breath monitoring in the time domain, while Bland-Altman showed a bias of −0.03 ± 1.78 breaths/min. Even in the case of lower camera resolution setting (i.e., NTSC), the system demonstrated good performances (MAE of 1.53 breaths/min, bias of −0.06 ± 2.08 breaths/min) for contactless monitoring of both breathing pattern and breath-by-breath respiratory rate over time.
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Yanagihara, Toyoshi, and Martin Kolb. "Molecular breath analysis for IPF: Can we make a few breaths count?" Respirology 24, no. 5 (February 12, 2019): 404–5. http://dx.doi.org/10.1111/resp.13503.

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Biagini, Denise, Jonathan Fusi, Annasilvia Vezzosi, Paolo Oliveri, Silvia Ghimenti, Alessio Lenzi, Pietro Salvo, et al. "Effects of long-term vegan diet on breath composition." Journal of Breath Research 16, no. 2 (February 1, 2022): 026004. http://dx.doi.org/10.1088/1752-7163/ac4d41.

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Abstract The composition of exhaled breath derives from an intricate combination of normal and abnormal physiological processes that are modified by the consumption of food and beverages, circadian rhythms, bacterial infections, and genetics as well as exposure to xenobiotics. This complexity, which results wide intra- and inter-individual variability and is further influenced by sampling conditions, hinders the identification of specific biomarkers and makes it difficult to differentiate between pathological and nominally healthy subjects. The identification of a ‘normal’ breath composition and the relative influence of the aforementioned parameters would make breath analyses much faster for diagnostic applications. We thus compared, for the first time, the breath composition of age-matched volunteers following a vegan and a Mediterranean omnivorous diet in order to evaluate the impact of diet on breath composition. Mixed breath was collected from 38 nominally healthy volunteers who were asked to breathe into a 2 l handmade Nalophan bag. Exhalation flow rate and carbon dioxide values were monitored during breath sampling. An aliquot (100 ml) of breath was loaded into a sorbent tube (250 mg of Tenax GR, 60/80 mesh) before being analyzed by thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). Breath profiling using TD-GC-MS analysis identified five compounds (methanol, 1-propanol, pentane, hexane, and hexanal), thus enabling differentiation between samples collected from the different group members. Principal component analysis showed a clear separation between groups, suggesting that breath analysis could be used to study the influence of dietary habits in the fields of nutrition and metabolism. Surprisingly, one Italian woman and her brother showed extremely low breath isoprene levels (about 5 pbv), despite their normal lipidic profile and respiratory data, such as flow rate and pCO2. Further investigations to reveal the reasons behind low isoprene levels in breath would help reveal the origin of isoprene in breath.
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Дисертації з теми "Breath analysi"

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Blackburn, Gavin J. "Breath analysis : methodology towards a fieldable breath analysis device." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/8518.

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In this work lung cancer is introduced along with the current detection methods. The inadequacies of the current situation are highlighted along with the need for better detection technologies that would allow for a more rigorous testing regime to be implemented. Metabolism and metabolites are introduced as potential biomarkers. The advanced detection techniques mass spectrometry (MS) and differential mobility spectrometry (DMS) are introduced and discussed with regard to being a fieldable device. The methods applicable to processing data generated by these instruments are discussed. Finally the research objectives are highlighted. The science of breath sampling is discussed along with the considerations when engaging in breath analysis research. Sampling and trapping of volatile organic compounds (VOCs) is discussed with particular emphasis on the adaptive breath sampler which was used in this work. The benefits of a dual detector instrument allowing for analysis of a single sample using both MS and DMS are outlined. The design and implementation of a parallel, two detector system is outlined including the intricacies of balancing the two columns that operate at different pressures and developing a mount Processing DMS data currently lags behind the current hardware available as there are no methods that allow the full data surface to be utilised. This work outlines a method for transforming DMS data from three dimensions to two dimensions while retaining the full information contained within the data surface. This method was tested with generated data sets to show its' utility and compared to the current standard processing method using real data sets. An understanding of all aspects of a clinical research project is vital to ensure the smooth running and completion of the project. The currently required documentation for an outside researcher to work within the NHS are detailed along with the expected timeframe for each step of designing, gaining ethical approval and implementing the research. The use of Gantt charts and work flow diagrams is highlighted and examples are given. An initial inspection of the data produced by a pilot study shows that there a several challenges that must be overcome, these are contamination and artefact peaks, retention time shifting, unresolved peaks, differing intensities in similar samples and the complexities of correctly identifying compounds found in breath samples. These are discussed and a workflow is highlighted.
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de, Silva Geethanga. "Technological Advancements in Breath Analysis." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1481031554793468.

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Paredi, Paolo. "Exhaled breath analysis in lung disease." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406498.

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Qiu, Yihong. "Measurement and analysis of breath sounds." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/1676/.

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Existing breath sound measurement systems and possible new methods have been critically investigated. The frequency response of each part of the measurement system has been studied. Emphasis has been placed on frequency response of acoustic sensors; especially, a method to study a diaphragm type air-coupler in contact use has been proposed. Two new methods of breath sounds measurement have been studied: laser Doppler vibrometer and mobile phones. It has been shown that these two methods can find applications in breath sounds measurement, however there are some restrictions. A reliable automatic wheeze detection algorithm based on auditory modelling has been developed. That is the human’s auditory system is modelled as a bank of band pass filters, in which the bandwidths are frequency dependent. Wheezes are treated as signals additive to normal breath sounds (masker). Thus wheeze is detectable when it is above the masking threshold. This new algorithm has been validated using simulated and real data. It is superior to previous algorithms, being more reliable to detect wheezes and less prone to mistakes. Simulation of cardiorespiratory sounds and wheeze audibility tests have been developed. Simulated breath sounds can be used as a training tool, as well as an evaluation method. These simulations have shown that, under certain circumstance, there are wheezes but they are inaudible. It is postulated that this could also happen in real measurements. It has been shown that simulated sounds with predefined characteristics can be used as an objective method to evaluate automatic algorithms. Finally, the efficiency and necessity of heart sounds reduction procedures has been investigated. Based on wavelet decomposition and selective synthesis, heart sounds can be reduced with a cost of unnatural breath sounds. Heart sound reduction is shown not to be necessary if a time-frequency representation is used, as heart sounds have a fixed pattern in the time-frequency plane.
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Heaney, Liam M. "Exhaled breath analysis in exercise and health." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21704.

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Research in the field of exhaled breath analysis is developing rapidly and is currently focussed on disease diagnosis and prognosis. The ability to identify early onset of life-threatening diseases, by a subtle change in exhaled profile that is picked up through a non-invasive measure, is of clinical interest. However, implementation of exhaled breath analysis can extend further beyond disease diagnosis and/or management. Using a non-invasive and rapid sample collection with high sensitivity, breath analysis may be seen to have potential benefit to the wider community. This research describes preliminary investigations into exhaled breath in exercise-based scenarios that aims to translate current breath analysis methodologies into a sport and exercise medicine context. An adaptive absorbent-based breath sampling methodology was used to collect a total of 220 breath samples from 54 participants over 3 studies. Breath volatiles were analysed using thermal desorption-gas chromatography-mass spectrometry. Data were analysed with targeted, and multivariate metabolomics-based approaches. Potential health impacts to high performance and recreational swimmers exposed to chlorinated water was studied. Following preliminary and scoping studies, 19 participants were sampled before a 30 min swim, and a further 5 times for 10 hrs after swimming. Environmental and control samples were also collected. Concentrations of chlorine-based disinfection by-products were observed to increase by up to a median of 121-fold, and take up to 8.5 hrs to return to pre-swimming levels. Metabolomic profiling identified the monoterpene geranylacetone to be a discriminant variable in samples taken 10 hrs after swimming. Geranylacetone is associated with membranes and extracellular fluids and an upregulated trend was observed across the five sampling time points post-swimming. Further research with an appropriately stratified and powered cohort (n=38) was recommended. The effects of intense exercise on breath profiles was explored for the possible use of breath analysis for exercise science with elite performance-based medicine. Twenty-nine participants provided exhaled breath samples before undergoing a maximal oxygen uptake (fitness) test and then provided 2 additional samples over the following 1 hr period. High and low fitness groupings, deemed by oxygen uptake values, were compared for exhaled metabolites. Lower exhaled acetone and isoprene were observed in participants with greater absolute oxygen uptake leading to a hypothesis for a non-invasive breath based fitness test. Finally, an interface for breath-by-breath analysis using a transportable mass spectrometer was developed. A controlled change in exhaled profiles was achieved through the ingestion of a peppermint oil capsule. Menthone was measured on-line and monitored for up to 10 hrs post-administration. Sixteen participants enabled the system to be demonstrated as exhaled menthone was at elevated concentrations for at least 6 hrs. Validation against thermal desorption-gas chromatography-mass spectrometry confirmed the system to be detecting metabolites at the sub-μg L-1 range.
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Modarreszadeh, Mohammad. "Systems analysis of breath to breath ventilatory variations in man: Role of carbon dioxide feedback." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055345140.

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Cummings, Beth L. "Applications of infrared laser spectroscopy to breath analysis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:5b6e0624-5982-457c-b13c-61484bace371.

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The work presented in this thesis is concerned with development of spectroscopic detection methods based on absorption spectroscopy using semiconductor lasers, with particular ref- erence to the field of medical diagnostics through breath analysis. The first part of this thesis deals with the design and testing of a prototype analyser for simultaneous monitoring of the exchange gases O2 , CO2 and H2O in breath. The aim of this analyser is to provide information required to monitor respiration, with potential use in intensive care monitoring or during anaesthesia. The relatively high concentrations of these gases in breath and read- ily available diode laser sources make detection in the near-infrared (NIR) ideal. However, the relatively weakly absorbing A-band O2 transitions at 760 nm require the application of a sensitive spectroscopic method, cavity enhanced absorption spectroscopy (CEAS). In contrast, CO2 and H2O are monitored using direct single pass absorption spectroscopy, with transitions arising from the 2ν1 + ν3 band at 2 μm and ν1 + ν3 band at 1.3 μm, respectively. It has been demonstrated that these gases can be detected simultaneously over a short pathlength (2.74 - 4 cm) in the respiratory flow by combining various spectroscopic methodologies and real-time data analysis. This analyser is shown to offer a viable alter- native for monitoring respiration, exhibiting absolute detection limits of changes of 0.26 % O2 , 0.02 % CO2 and 0.003 % H2O with a 10 ms time resolution, which are comparable to current mass spectrometry based methods, but without their inherent delays. Following this, investigations into the detection of the main gas constituents in breath in the NIR employing noise-reduction modulation based spectroscopic techniques, namely wavelength and frequency modulation (WMS and FMS respectively) are also reported. The described WMS studies on water at 1.37 μm provide a demonstration of conventional WMS detection, as well as a “proof-of-principle” example of a relatively new approach to calibrating the non-absolute information obtained from a WMS absorption signal. Typically WMS spectra are calibrated using mixtures of known gas concentrations or an absolute direct absorption spectrum where possible. In this work however, a self-calibrating method, the phasor decomposition method (PDM), is employed and the returned concentration from this calibration is compared to direct absorption measurement. From this, the calculated concentration using the PDM is found to differ by 9 % from the concentration value obtained by direct absorption, providing an alternative method of calibration for when direct absorption measurements are not possible. The use of FMS in the NIR is also demonstrated as a potential alternative to CEAS for monitoring O2 at 760 nm. FMS detection is performed on atmospherically broadened O2 and a time-normalised αmin(t) of 2.45 ×10−6 cm−1 s1/2 is obtained, which is two orders of magnitude less sensitive than the value of αmin(t) = 2.35 ×10−8 cm−1 s1/2 obtained with CEAS. This combined with the experimental requirements of an FMS system, make its use for detection of O2 a less practicable option compared to CEAS for real-time breath analysis. The latter work in this thesis involves a change in focus to detection of trace gases in breath in the mid-infrared (MIR). The move of spectroscopic detection to the MIR exploits the larger absorption cross-sections available in this region, and to achieve this, a relatively new form of semiconductor laser, the quantum cascade laser (QCL) is used. The design of a continuous wave QCL spectrometer at 8 μm and its operating characteristics are demon- strated and improvements in its performances are also discussed. This QCL system is then utilised to demonstrate the potential of monitoring species in breath, namely the narrow- band absorber methane and the broadband absorber acetone, taking into consideration the potential interference from other absorbing species in breath and the different spectroscopic characteristics exhibited by these molecules. Finally, the potential to further improve the sensitive detection of trace gases in breath in the MIR is also investigated with studies on the use of CEAS and multipass cells. In this work, the molecule of interest is the biomarker OCS, using transitions of the 2ν2 band at 1031 cm−1 , that are probed using a 10 μm QCL. The application of CEAS in the MIR is not as well developed as in the NIR, and the experimental consequences of using optical cavities at these wavelengths, where equipment tends to be more limited, are investigated and sensitivities discussed in the context of other literature. The experimental procedure of optimising a cavity for CEAS using the off-axis alignment method is also studied in detail, as well as the addition of WMS to further improve the signal quality. An effective absorption pathlength of ∼ 100 m was achieved in the cavity, with a bandwidth reduced αmin(BW) of 1.7 ×10−7 cm−1 Hz−1/2 using WMS CEAS achieved. With the poorer quality optics and limitations in equipment in the MIR for CEAS experiments, the use of a multipass cell, a 238 m Herriott cell, is also investigated as an alternative to the use of an optical cavity at 10 μm. Detection of OCS using direct absorption and WMS is demonstrated in the Herriott cell, achieving αmin(BW) = 2.03×10−8 cm−1 Hz−1/2 using WMS. This shows an improvement in sensitivity compared to WMS CEAS, and also shows the potential for future work on biomarker detection, as it approaches the ∼ ppb levels required for breath analysis.
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Hamblin, D'Nisha D. "Exhaled Breath Analysis of Smokers Using CMV-GC/MS." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2605.

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The aim of this research was to demonstrate the potential of the novel pre-concentration device, capillary microextraction of volatiles (CMV), for breath analysis. The CMV offers dynamic sampling of volatile organic compounds with its simple coupling to a GC inlet for GC/MS analysis, avoiding expensive thermal desorption instrumentation needed for sorbent tubes, as well as an increased surface area over a single SPME fiber. CMV collectively identified 119 compounds in the breath of 13 self-reported smokers and 7 nonsmokers. The presence and intensity of twelve compounds were used to classify all the nonsmokers 100% of the time using Principal Component Analysis to elucidate the groupings. In some cases, nicotine was not detected in smokers and they were confused with the nonsmokers. Nicotine was detected in the breath of 69% of smokers with an average mass of 143 ± 31 pg for cigarette smokers from the approximate 5 L sample of breath collected. The successful use of the CMV sampler and preconcentration of breath to distinguish between smokers and nonsmokers served as a proof of concept for future applications of the CMV for detection of marijuana smokers’ breath for impaired driver management.
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Meli, Louis Marcel. "Breath analysis : investigation of a low cost FTIR approach." Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316270.

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Khalid, Tanzeela Yasmin. "Breath analysis for the early recognition of hepatic encephalopathy." Thesis, University of the West of England, Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.573489.

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Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops commonly in liver cirrhosis following the build up of toxic substances in the blood that cross the blood-brain barrier and affect normal brain function. The diagnosis of HE is difficult due to only subtle impairments of cognitive function at early stages of the disease and the lack of a gold standard test that specifically and reliably detects the condition. HE is associated with a poor prognosis and effective treatment largely depends on early diagnosis. Thus the aim of this work was to investigate the use of breath analysis as a non-invasive and simpler means of diagnosing HE in cirrhotic patients. This was based on the hypothesis that toxins accumulating in the blood may, if sufficiently volatile, undergo alveolar gas exchange in the lungs to be excreted in the breath. Bespoke breath testing devices were utilised for the collection of breath onto Solid-Phase Micro-Extraction (SPME) fibres and adsorbent packed Automated Thermal Desorption (A TD) tubes from cirrhotic patients with and without HE, patients with early alcohol-related health problems, patients with respiratory disease, and healthy controls. Analysis of the breath samples collected was undertaken using Gas Chromatography Mass Spectrometry. In total, 237 different compounds were identified from all samples collected using the SPME breath analyser system and 385 using the ATD breath sampling device. Multivariate discriminant analysis was used to identify Volatile Organic Compounds (VOCs) that will discriminate patients according to disease status. More compounds were associated with the presence of HE compared to the absence of HE in alcoholic cirrhotic patients. Classification rules based on the presence or absence of volatiles correctly classified the presence of HE in 86% of patients tested with the SPME technique and 88% of patients tested with the A TD technique. Breath tests based on the presence or absence of discriminatory volatiles, correctly predicted the presence of cirrhosis in 93% and 96% of alcoholic patients tested using the SPME and ATD techniques, respectively. The presence or absence of four key volatiles on the breath also helped discriminate patients with early alcohol related health problems (ARHP) from healthy cases, correctly predicting the presence of ARHP in 78% and 91 % of alcoholic patients tested using the SPME and ATD systems, respectively. The use of a targeted sensor-array device found that, on average, HE patients exhaled higher concentrations of hydrogen, alcohol, and total VOCs compared to alcoholic cirrhotic patients without clinical signs of HE, especially in the non- smoking cohort of subjects studied. This finding shows that the use of gas sensor technologies in clinical practice can provide useful diagnostic information for clinical conditions at the bedside of patients in real-time. Not all breath volatiles come from the alveolar-blood interface; many can also be produced in the oral cavity by the action of bacterial or salivary enzymes on a range of substrates. Thus gases were sampled from tongue biofilm models in vitro and this identified 32 compounds commonly detected on breath. This highlights the need for further research to determine the major source of breath volatiles in order that suitable markers of systemic disease or metabolic disorders can be identified. Overall, the results reported in this thesis suggest that breath analysis is a useful tool for the non-invasive diagnosis of a range of conditions associated with the liver such as HE, cirrhosis, and, most importantly the presence of early alcohol related health problems before any significant damage to the liver has occurred.
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Книги з теми "Breath analysi"

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Weigl, Stefan, ed. Breath Analysis. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18526-7.

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Zhang, David, Dongmin Guo, and Ke Yan. Breath Analysis for Medical Applications. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4322-2.

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Dubowski, Kurt M. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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Dubowski, Kurt M. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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Dubowski, Kurt M. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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Dubowski, Kurt M. The technology of breath alcohol analysis. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1992.

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Dubowski, Kurt M. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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Dubowski, Kurt M. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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Dubowski, Kurt M. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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10

National Institute on Alcohol Abuse and Alcoholism (U.S.), ed. The technology of breath-alcohol analysis. Rockville, Md. (5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1991.

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Частини книг з теми "Breath analysi"

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Hunt, Thomas E. "Late Antique Cultures of Breath: Politics and the Holy Spirit." In The Life of Breath in Literature, Culture and Medicine, 69–84. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-74443-4_4.

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AbstractUsing sources from the fourth century CE, Thomas E. Hunt analyses how people imagined breath in late antiquity. Breathing was a way to mark out and understand human difference in the complex social world of the late Roman Empire. In this context, a person’s breath was used to judge the quality of their social relationships. Breath also held cosmic import, for when a person drew in air they participated in the wider structure of the universe. Christian writers described the inner life of God by referring to these models of breath and breathing. In this essay, Hunt shows how social and theological accounts of breathy relation reinforced each other.
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Dolch, Michael, Siegfried Praun, Johannes Villiger, Alexander Choukér, and Gustav Schelling. "Breath Gas Analysis." In Stress Challenges and Immunity in Space, 451–61. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-16996-1_24.

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Dolch, Michael, Siegfried Praun, Johannes Villiger, Alexander Choukèr, and Gustav Schelling. "Breath Gas Analysis." In Stress Challenges and Immunity in Space, 289–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22272-6_21.

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Kharitonov, Sergei A., and Peter J. Barnes. "Exhaled Breath Analysis." In New Drugs for Asthma, Allergy and COPD, 44–47. Basel: KARGER, 2001. http://dx.doi.org/10.1159/000062127.

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Hadjileontiadis, Leontios J., and Zahra M. K. Moussavi. "Current Techniques for Breath Sound Analysis." In Breath Sounds, 139–77. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71824-8_9.

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Moussavi, Zahra. "Breath Sounds Recording." In Fundamentals of Respiratory System and Sounds Analysis, 17–18. Cham: Springer International Publishing, 2006. http://dx.doi.org/10.1007/978-3-031-01617-2_3.

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Lawlor, Clark. "Romantic Consumption: The Paradox of Fashionable Breath." In The Life of Breath in Literature, Culture and Medicine, 285–304. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-74443-4_14.

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AbstractThe tragic disease of consumption/tuberculosis is, perhaps notoriously, a central disease of literary and artistic international Romanticism, as well as having a profound influence in wider society. Lawlor’s essay analyses the role that breath played in this phenomenon: how could breath and breathlessness possibly contribute to the valorisation of such a horrible illness? Using literary and medical works, this analysis demonstrates that the ‘reality’ (albeit variable) of consumptive breath was often overridden, overwritten, or reframed, by cultural discourses which included religious and classical concepts of breath, new and old medical models, gender and social rank.
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Marron, J. S., and Ian L. Dryden. "Breadth of OODA." In Object Oriented Data Analysis, 19–30. Boca Raton: Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9781351189675-2.

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Zhang, David, Dongmin Guo, and Ke Yan. "Breath Signal Analysis for Diabetics." In Breath Analysis for Medical Applications, 241–58. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4322-2_13.

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Hughson, Richard L., and George D. Swanson. "Breath-By-Breath Gas Exchange: Data Collection and Analysis." In Respiratory Control, 179–90. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0529-3_20.

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Тези доповідей конференцій з теми "Breath analysi"

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Reis, Yedda Nunes, Bruna Salani Mota, Marcos Desiderio Ricci, Carlos Shimizu, Fernando Nalesso Aguiar, Natalia Paula Cardoso, Edmund Chada Baracat, and José Roberto Filassi. "MACROSCOPIC EXAMINATION OF BREAST DENSITY CORRELATION WITH MAMMOGRAPHIC BREAST DENSITY IN BREAST CANCER–CONSERVING SURGERY: A RETROSPECTIVE ANALYSIS." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2059.

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Objective: The aim of this study is to evaluate the association between mammographic breast density (MBD) and macroscopic examination of breast density (MEBD), as well as the association between MEBD and multiple clinical and tumoral characteristics. Methodology: The secondary (i.e., retrospective) analysis from a prospective database (BREAST-MRI trial) was performed. Patients with breast cancer stages 0 to III for breast-conserving surgery, from November 2014 to October 2018, were selected. All patients were evaluated with clinical examination, breast ultrasound, and mammography and stratified by MBD. Then, they were randomized on a 1:1 basis in two groups whether to perform breast magnetic resonance imaging. Analysis of the subset of patients’ MEBD in the clinical trial was not prespecified. MEBD was estimated by calculating the ratio of stromal and fatty tissues in each breast histopathological sample, and then, patients were classified similarly to ACR BI-RADS® criteria. Results: A total of 431 MEBD were selected for the analysis. MEBD classification was distributed as follows: 303 (70.3%) were classified as A, 85 (19.7%) as B, 36 (8.4%) as C, and 7 (1.6%) as D. There is no association between MBD and MEBD in our breast surgical specimens, such that MEBD A, B, C, and D were associated with MBD in 22 (97.1%) of 24 A breasts, 34 (18.2%) of 187 B breasts, 26 (13.1%) of 199 C breasts, and 1 (4.8%) of 21 D breasts (p<0.001). Breasts with the highest fat content in the macroscopic analysis were associated with older patients, higher body mass index, multiparity, and postmenopausal status (p=0.001). There was no difference among groups regarding the history of hormone replacement therapy, clinical stage, and immunohistochemical. Conclusion: Our study shows that MEBD does not hold a close correlation with MBD, according to the ACR BI-RADS classification.
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Qin, Manqing, Xinghua Li, and Jicheng Zhao. "Analysis of Dynamic Effects Associated With Postulated Breaks of Piping." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-15273.

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High energy pipe break hypothesis and engineering practice shall be taken into account and performed during nuclear power plant design due to defense-in-depth concept unless leak-before-break or break preclusion concept is applied. High energy pipe breaks potentially occur in the high stress area and break locations can be recognized by specific regulations based on mechanical analysis of piping systems. Engineering measures shall be applied to mitigate the consequences caused by high energy pipe breaks later. From engineering point of view High Energy Line Break analysis requires an essential knowledge in the different fields, such as: structural and dynamic mechanics, hydrodynamics, plant arrangements and so on. Aims of this paper consist of two aspects: definition of break locations associated with engineering practice of piping stress analysis and a conservative model of anti-whip analysis based on some assumptions. Comparison results are given after analytical investigation of the piping whip analysis with different numerical modeling and tools at the same time. An example of such comparison between transient model and energy balance methods is performed based on some basic assumptions in relation to specific piping layout. The simplified calculation model appears well for a conservative estimation of pipe whip characteristics, both for maximum displacements of piping and maximum loads impacted on anti-whip restraints.
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Dam, Quyen B., Linh T. Nguyen, Son T. Nguyen, Nam H. Vu, and Cuong Pham. "e-Breath: Breath Detection and Monitoring Using Frequency Cepstral Feature Fusion." In 2019 International Conference on Multimedia Analysis and Pattern Recognition (MAPR). IEEE, 2019. http://dx.doi.org/10.1109/mapr.2019.8743533.

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Running, During. "Biomechanical Model of Bare-Breasts." In Applied Human Factors and Ergonomics Conference. AHFE International, 2020. http://dx.doi.org/10.54941/ahfe100423.

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Sports bras are designed to reduce mammary glands or breast movement during exercises, but there is no standardized, valid and reliable method to evaluate relative three-dimensional (3D) breast movement; and there is no literature to predict the 3D force acting on the breasts during activities. A reliable method is essential to evaluate 3D breast movement and to determine the effective design features of supportive sports bras. This study derived and validated a new Breast Coordinate System (BCS) for investigating 3D breast movement, so as to identify the most effective bra features and to analyze the effects of breast volume and bra strap properties on breast movement, then to develop theoretical models of breast force generated during bare-breasted running. In the light of this, 3D mechanical models have been developed based on a system comprising a mass, springs and dampers. The orthogonal force exerted on the breasts during running was derived. The predicted results of maximum breast force were verified with previous literature. The new methods will contribute to future research on human locomotion and the design of close-fitting garments.
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RISBY, T. H. "CURRENT STATUS OF CLINICAL BREATH ANALYSIS." In Conference Breath Gas Analysis for Medical Diagnostics. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701954_0017.

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"BACK MATTER." In Conference Breath Gas Analysis for Medical Diagnostics. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701954_bmatter.

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"FRONT MATTER." In Conference Breath Gas Analysis for Medical Diagnostics. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701954_fmatter.

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PHILLIPS, M. "HOW TO ANALYZE BREATH AND MAKE SENSE OF THE DATA: A PERSONAL VIEW." In Conference Breath Gas Analysis for Medical Diagnostics. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701954_0019.

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VON BASUM, G., D. HALMER, P. HERING, and M. MÜRTZ. "LASER SPECTROSCOPIC ON-LINE MONITORING OF EXHALED TRACE GASES." In Conference Breath Gas Analysis for Medical Diagnostics. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701954_0005.

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DOLINAY, T., A. M. K. CHOI, and S. W. RYTER. "CAN INHALATION CARBON MONOXIDE BE UTILIZED AS A THERAPEUTIC MODALITY IN HUMAN DISEASES?" In Conference Breath Gas Analysis for Medical Diagnostics. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701954_0015.

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Звіти організацій з теми "Breath analysi"

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Saldanha, Ian J., Wangnan Cao, Justin M. Broyles, Gaelen P. Adam, Monika Reddy Bhuma, Shivani Mehta, Laura S. Dominici, Andrea L. Pusic, and Ethan M. Balk. Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis. Agency for Healthcare Research and Quality (AHRQ), July 2021. http://dx.doi.org/10.23970/ahrqepccer245.

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Objectives. This systematic review evaluates breast reconstruction options for women after mastectomy for breast cancer (or breast cancer prophylaxis). We addressed six Key Questions (KQs): (1) implant-based reconstruction (IBR) versus autologous reconstruction (AR), (2) timing of IBR and AR in relation to chemotherapy and radiation therapy, (3) comparisons of implant materials, (4) comparisons of anatomic planes for IBR, (5) use versus nonuse of human acellular dermal matrices (ADMs) during IBR, and (6) comparisons of AR flap types. Data sources and review methods. We searched Medline®, Embase®, Cochrane CENTRAL, CINAHL®, and ClinicalTrials.gov from inception to March 23, 2021, to identify comparative and single group studies. We extracted study data into the Systematic Review Data Repository Plus (SRDR+). We assessed the risk of bias and evaluated the strength of evidence (SoE) using standard methods. The protocol was registered in PROSPERO (registration number CRD42020193183). Results. We found 8 randomized controlled trials, 83 nonrandomized comparative studies, and 69 single group studies. Risk of bias was moderate to high for most studies. KQ1: Compared with IBR, AR is probably associated with clinically better patient satisfaction with breasts and sexual well-being but comparable general quality of life and psychosocial well-being (moderate SoE, all outcomes). AR probably poses a greater risk of deep vein thrombosis or pulmonary embolism (moderate SoE), but IBR probably poses a greater risk of reconstructive failure in the long term (1.5 to 4 years) (moderate SoE) and may pose a greater risk of breast seroma (low SoE). KQ 2: Conducting IBR either before or after radiation therapy may result in comparable physical well-being, psychosocial well-being, sexual well-being, and patient satisfaction with breasts (all low SoE), and probably results in comparable risks of implant failure/loss or need for explant surgery (moderate SoE). We found no evidence addressing timing of IBR or AR in relation to chemotherapy or timing of AR in relation to radiation therapy. KQ 3: Silicone and saline implants may result in clinically comparable patient satisfaction with breasts (low SoE). There is insufficient evidence regarding double lumen implants. KQ 4: Whether the implant is placed in the prepectoral or total submuscular plane may not be associated with risk of infections that are not explicitly implant related (low SoE). There is insufficient evidence addressing the comparisons between prepectoral and partial submuscular and between partial and total submuscular planes. KQ 5: The evidence is inconsistent regarding whether human ADM use during IBR impacts physical well-being, psychosocial well-being, or satisfaction with breasts. However, ADM use probably increases the risk of implant failure/loss or need for explant surgery (moderate SoE) and may increase the risk of infections not explicitly implant related (low SoE). Whether or not ADM is used probably is associated with comparable risks of seroma and unplanned repeat surgeries for revision (moderate SoE for both), and possibly necrosis (low SoE). KQ 6: AR with either transverse rectus abdominis (TRAM) or deep inferior epigastric perforator (DIEP) flaps may result in comparable patient satisfaction with breasts (low SoE), but TRAM flaps probably increase the risk of harms to the area of flap harvest (moderate SoE). AR with either DIEP or latissimus dorsi flaps may result in comparable patient satisfaction with breasts (low SoE), but there is insufficient evidence regarding thromboembolic events and no evidence regarding other surgical complications. Conclusion. Evidence regarding surgical breast reconstruction options is largely insufficient or of only low or moderate SoE. New high-quality research is needed, especially for timing of IBR and AR in relation to chemotherapy and radiation therapy, for comparisons of implant materials, and for comparisons of anatomic planes of implant placement.
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Robbins, Bryant, and Maureen Corcoran. Calculation of levee-breach widening rates. Engineer Research and Development Center (U.S.), May 2022. http://dx.doi.org/10.21079/11681/44163.

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Inundation modeling is often conducted for levee systems to understand current flood risks. The extent of inundation caused by a breach in the levee is highly influenced by the widening rate of the levee breach. This study presents an approach for calculating levee-breach widening rates based on average flow velocity through the breach, embankment height, and erosion characteristics of the soil. Estimates of soil erodibility are derived through an analysis of the measurements of soil erodibility presented in the National Cooperative Highway Research Program (NCHRP) Report 915 database. Levee-breach widening rate curves are calculated based on these erosion properties to demonstrate the approach, and default curves are presented for typical levees built from coarse-grained soils and fine-grained soils. While the most accurate approach for a site is to calculate site-specific widening rate curves based on estimates of local soil erodibility, the default curves presented provide a suitable starting point for initial inundation modeling.
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He, zhe, liwei Xing, ming He, yuhuan Sun, jinlong Xu, and rong Zhao. Effect of Acupuncture on Mammary Gland Hyperplasia (MGH): a Bayesian network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0058.

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Review question / Objective: This review aims at conducting a network meta-analysis to assess the potential therapeutic effectiveness and safety of acupuncture therapy for the treatment of MGH. Condition being studied: MGH is a benign breast disease caused by excessive growth of mammary duct epithelial cells and interstitial fibers. Its prevalence rate among women of childbearing age is about 13.5-42%, accounting for 99.3% of the total number of patients with breast related diseases, and its possibility of developing breast cancer can reach 5-10%. Breast hyperplasia can cause clinical symptoms such as breast pain, breast lump, nipple pigmentation and mood fluctuation, which brings severe physical and mental burden to patients. Modern medicine believes that the pathogenesis of MGH is related to sexual hormone disorder secondary to hypothalamus pituitary ovary axis dysfunction.At present, the treatment options of MGH are limited and not completely effective. The commonly used drugs in clinical practice, such as tamoxifen, danazol and goserelin, are expensive, which may lead to breast pain, swelling and increase of interstitial fibrous nodules, and the long-term use of MGH has huge side effects. The clinical guidelines recommend that the use time should be 2 to 6 months. Therefore, it is necessary to seek a treatment method of MGH that is effective, stable and safe.
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Hernandez-Abrams, Darixa, Carra Carrillo, and Todd Swannack. Scenario analyses in ecological modeling and ecosystem management. Engineer Research and Development Center (U.S.), July 2022. http://dx.doi.org/10.21079/11681/44840.

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Ecosystem management and restoration practitioners are challenged with complex problems, diverse project goals, multiple management alternatives, and potential future scenarios that change the systems of interest. Scenario analysis aids in forecasting, evaluating, and communicating outcomes of potential management actions under different plausible conditions, such as land-use change or sea level rise. However, little guidance exists for practitioners on the utility and execution of scenario analysis. Therefore, this technical note highlights the usefulness of scenario analysis as a tool for addressing uncertainty in potential project outcomes. The mechanics of the scenario-analysis process are explained, and examples of different types of scenario analyses are described for context on the breadth of its use. Lastly, two hypothetical case studies of scenario analysis in ecological modeling are presented showing a semiquantitative approach for assessing anadromous fish and a quantitative approach examining freshwater mussel habitat. Overall, this technical note provides a brief review of the utility and application of scenario analyses in the context of ecological modeling and ecosystem management decision-making.
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Lin, Yawei, Yi Chen, Rongrong Liu, and Baohua Cao. Effect of exercise on rehabilitation of breast cancer surgery patients: A systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0065.

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Review question / Objective: Exercise after breast cancer surgery has proved beneficial to rehabilitation. We evaluate the best exercise for different post-surgery complications. Information sources: China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP China Science and Technology Journal Database, China Biology Medicine, EMBASE and PubMed databases were searched. Combinations of breast cancer (“breast tumor”,“breast carcinoma”,“mammary carcinoma”,“breast neoplasm”) and rehabilitation exercise (“exercise”,“physical therapy”) were employed when screening abstracts/keywords of articles. Two researchers independently searched, read the title and abstract of the literature, read the full text of the preliminary included literature, and extracted the data. In case of divergence, a third researcher was consulted.
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Pawlowski, Wojtek P., and Avraham A. Levy. What shapes the crossover landscape in maize and wheat and how can we modify it. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600025.bard.

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Анотація:
Meiotic recombination is a process in which homologous chromosomes engage in the exchange of DNA segments, creating gametes with new genetic makeup and progeny with new traits. The genetic diversity generated in this way is the main engine of crop improvement in sexually reproducing plants. Understanding regulation of this process, particularly the regulation of the rate and location of recombination events, and devising ways of modifying them, was the major motivation of this project. The project was carried out in maize and wheat, two leading crops, in which any advance in the breeder’s toolbox can have a huge impact on food production. Preliminary work done in the USA and Israeli labs had established a strong basis to address these questions. The USA lab pioneered the ability to map sites where recombination is initiated via the induction of double-strand breaks in chromosomal DNA. It has a long experience in cytological analysis of meiosis. The Israeli lab has expertise in high resolution mapping of crossover sites and has done pioneering work on the importance of epigenetic modifications for crossover distribution. It has identified genes that limit the rates of recombination. Our working hypothesis was that an integrative analysis of double-strand breaks, crossovers, and epigenetic data will increase our understanding of how meiotic recombination is regulated and will enhance our ability to manipulate it. The specific objectives of the project were: To analyze the connection between double-strand breaks, crossover, and epigenetic marks in maize and wheat. Protocols developed for double-strand breaks mapping in maize were applied to wheat. A detailed analysis of existing and new data in maize was conducted to map crossovers at high resolution and search for DNA sequence motifs underlying crossover hotspots. Epigenetic modifications along maize chromosomes were analyzed as well. Finally, a computational analysis tested various hypotheses on the importance of chromatin structure and specific epigenetic modifications in determining the locations of double-strand breaks and crossovers along chromosomes. Transient knockdowns of meiotic genes that suppress homologous recombination were carried out in wheat using Virus-Induced Gene Silencing. The target genes were orthologs of FANCM, DDM1, MET1, RECQ4, and XRCC2.
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Шестопалова (Бондар), К. М., and Н. В. Квітка. Psychological Mechanisms of Anticipation of Professional Worldview. Federal University of Santa Catarina - UFSC, 2021. http://dx.doi.org/10.31812/123456789/6109.

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Анотація:
This research explores the mechanisms of anticipation, understood in a broad sense as a forward-looking ability. Authors analyze the ability of anticipation of early adulthood respondents; 2) to analyze professional representations of early adulthood respondents; 3) to investigate a relationship between the level of anticipation ability and breadth of professional representations of respondents.
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Wang, Ying yuan, Zechang Chen, Luxin Zhang, Shuangyi Chen, Zhuomiao Ye, Tingting Xu, and Yingying Zhang c. A systematic review and network meta-analysis: Role of SNPs in predicting breast carcinoma risk. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0092.

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Review question / Objective: P: Breast cancer patient; I: Single nucleotide polymorphisms associated with breast cancer risk; C: Healthy person; O: By comparing the proportion of SNP mutations in the tumor group and the control group, the effect of BREAST cancer risk-related SNP was investigated; S: Case-control study. Condition being studied: Breast cancer (BC) is one of the most common cancers among women, and its morbidity and mortality have continued to increase worldwide in recent years, reflecting the strong invasiveness and metastasis characteristics of this cancer. BC is a complex disease that involves a sequence of genetic, epigenetic, and phenotypic changes. Polymorphisms of genes involved in multiple biological pathways have been identified as potential risks of BC. These genetic polymorphisms further lead to differences in disease susceptibility and severity among individuals. The development of accurate molecular diagnoses and biological indicators of prognosis are crucial for individualized and precise treatment of BC patients.
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Zhao, YiHao, and Dongbin Zhang. Efficacy and safety of trastuzumab combined with neoadjuvant chemotherapy in Chinese patients with HER-2 positive breast cancer: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0003.

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Review question / Objective: To systematically evaluate the efficacy and safety of docetaxel combined with carboplatin and trastuzumab (TCH) neoadjuvant chemotherapy in Chinese patients with HER2-positive breast cancer. Condition being studied: Chinese patients who have been clinically diagnosed as HER-2 positive breast cancer, not complicated with basic diseases such as heart, liver and bone marrow, and who have received established surgery after chemotherapy and cooperated with follow-up. Eligibility criteria: Non-randomized controlled trials, animal experiments, literature review, non-docetaxel combined with carboplatin and trastuzumab as adjuvant therapy in Chinese breast cancer patients, and other drugs used in the intervention group or control group.
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Qin, Ling, Qiyu Liu, Hui Wang, and Lipeng Sun. Accuracy of ultrasound in distinguishing pathology of malignant thyroid diseases: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0072.

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Анотація:
Review question / Objective: This meta-analysis aimed to determine the accuracy of ultrasound in distinguishing pathology of malignant thyroid diseases. Eligibility criteria: Type of study. This study will only include high quality clinical cohort or case control studies. Type of patients. The patients should be those who had undergone breast diseases. Intervention and comparison. This study compares AI with pathology for diagnosing breast diseases. Type of outcomes. The primary outcomes include sensitivity, specificity, positive and negative likelihood ratio, diagnostic odds ratio, and the area under the curve of the summary receiver operating characteristic.
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