Готові списки джерел за темами / Blood groups ABO system Molecular aspects

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Добірка наукової літератури з теми "Blood groups ABO system Molecular aspects"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 29 січня 2023

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Статті в журналах з теми "Blood groups ABO system Molecular aspects"

Xu, Hui, Zunmin Zhu, Xiaojian Zhu, Na Shen, Shu Zhou, and Yicheng Zhang. "The Interaction of Tumor Cells and Myeloid-Derived Suppressor Cells in Chronic Myelogenous Leukemia." Blood 134, Supplement_1 (November 13, 2019): 1636. http://dx.doi.org/10.1182/blood-2019-125563.

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Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease characterized by the formation of the BCR-ABL fusion gene. At present, basic studies of the pathogenesis of relapse after stopping tyrosine kinase inhibitors (TKIs) treatment have mainly concentrated on two main aspects: the leukemia stem cells (LSCs) and the tumor microenvironment. However, whether relapse or non-relapse patients who discontinued TKIs therapy, LSCs are still exist. Among a variety of factors that compose the CML microenvironment, myeloid-derived suppressor cells (MDSC) are considered to be a strong contributor to the immunosuppressive tumor microenvironment. Here, we designed the study to investigate the potential relation between tumor cells and MDSC in CML and find risk factors for relapse after discontinuation. We detected the percentage of MDSC and the BCR-ABL (IS) transcript levels in bone marrow of 50 CML patients in chronic phase at our center. The data indicated that the frequency of MDSC had significant positive correlation with BCR-ABL (IS) transcript levels (Figure 1A). In addition, the counts of MDSC had significant difference at different response stages (Figure 1B), especially the M-MDSC, a subtype of MDSC. The percentage of M-MDSC was significantly higher in patients with newly diagnosed or complete hematological response (CHR) or major molecular response (MMR) compared with those of CML patients obtained complete molecular response (CMR) (Figure 1C). When K562 cells or CD34+ cells were cocultured with M-MDSC at a 1:10 ratio, K562 cells or CD34+ cells proliferated significantly at day 3 (Figure 1D and E). K562 subcutaneous tumor formation in BALB/c node mice confirmed that tumors weight and volume of the coculture group were higher than control. Then, we further investigated whether tumor cells have an impact on MDSC through microvesicles (MV). After adding K562-MV to peripheral blood mononuclear cells (PBMCs) from healthy donors, MDSC counts appeared significantly elevated in the different K562 cells counts group compared to the control group (Figure 1F).To analyze the roles of K562-MV collected before and after TKIs discontinuation on MDSC, we established a TKIs discontinuation model using the K562 cell, which emulates the cessation of TKIs treatment of CML patients in some extent. The results showed that regardless of the Imatinib or Dasatinib treatment, a significant increase was observed in the proportion of MDSC after TKIs treatment cessation compared with the TKIs treatment groups (Figure 1G). Experiments in vivo also proved K562-MV after different treatments promoted the proliferation of MDSC (Figure 1H and I). In conclusion, our study introduces the notion of the role of MDSC as mediators in the cross talk between tumor cells and the microenvironment. MDSC would provide a novel and useful model to predict the relapse of CML by establishing a type of new risk stratification system. MDSC could be also act as a promising target in the relapse of CML. In addition, we found a mutual promotion of proliferation of tumor cells and MDSC, this bidirectional interaction results in a vicious cycle by providing a protective niche against immune attacks. Therapeutic interventions modulating this interaction might accelerate the success of treatment-free remission. Figure 1 Disclosures No relevant conflicts of interest to declare.

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Hosoi, Eiji. "Biological and clinical aspects of ABO blood group system." Journal of Medical Investigation 55, no. 3,4 (2008): 174–82. http://dx.doi.org/10.2152/jmi.55.174.

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Reid, Marion E., and Agnes Hallie Lee. "ABO blood group system: a rev i ew of molecular aspects." Immunohematology 16, no. 1 (2020): 1–6. http://dx.doi.org/10.21307/immunohematology-2019-572.

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Ponce de León, Patricia, and Juana Valverde. "ABO System: molecular mimicry of Ascaris lumbricoides." Revista do Instituto de Medicina Tropical de São Paulo 45, no. 2 (April 2003): 107–8. http://dx.doi.org/10.1590/s0036-46652003000200011.

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A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined. Extracts of A. lumbricoides [AE] were prepared by surgical remotion of the cuticle and refrigerated mechanical rupture. Agglutination Inhibition (AI) and Hemoagglutination Kinetics (HK) tests were used with the [AE]. Of the 28 [AE], eight belonged to O group patients, 15 to A group, three to B group and the remaining two to AB children. The AI Test showed A epitopes in two [AE] of group A patients and B epitopes in two [AE] of group B patients. The HK Test showed B antigenic determiners in two [AE] of group B patients and in two [AE] of group AB patients as well as A antigenic determiners in one [AE] of A group patient. Of the 28 [AE] studied in both tests B epitopes were detected in all [AE] from B and AB patients and A epitopes in three of the 15 [AE] of group A patients. The experiments carried out suggest that A. lumbricoides might absorb A and B antigens from the host, and/or modify the cuticular carbohydrates expression as a kind of antigenic mimicry.

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Mirzaei Gheinari, Fahimeh, Fatemeh Sakhaee, Melika Gholami, Fattah Sotoodehnejadnematalahi, Mohammad Saber Zamani, Iraj Ahmadi, Enayat Anvari, and Abolfazl Fateh. "ABO rs657152 and Blood Groups Are as Predictor Factors of COVID-19 Mortality in the Iranian Population." Disease Markers 2022 (November 14, 2022): 1–8. http://dx.doi.org/10.1155/2022/5988976.

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Several studies have discovered a relationship between specific blood types, genetic variations of the ABO gene, and coronavirus disease 2019 (COVID-19). Therefore, the aim of this study was to evaluate the association between ABO rs657152 polymorphisms and ABO blood groups with COVID-19 mortality. The tetraprimer amplification refractory mutation system, polymerase chain reaction method, was used for ABO rs657152 polymorphism genotyping in 1,211 dead and 1,442 improved patients. In the current study, the frequency of ABO rs657152 AA than CC genotypes was significantly higher in dead patients than in improved patients. Our findings indicated that blood type A was associated with the highest risk of COVID-19 mortality compared to other blood groups, and patients with blood type O have a lower risk of infection, suggesting that blood type O may be a protective factor against COVID-19 mortality. Multivariate logistic regression test indicated that higher COVID-19 mortality rates were linked with alkaline phosphatase, alanine aminotransferase, high density lipoprotein, low-density lipoprotein, fasting blood glucose, uric acid, creatinine, erythrocyte sedimentation rate, C-reactive protein, 25-hydroxyvitamin D, real-time PCR Ct values, ABO blood groups, and ABO rs657152 AA genotype. In conclusion, the AA genotype of ABO rs657152 and blood type A were associated with a considerably increased frequency of COVID-19 mortality. Further research is necessary to validate the obtained results.

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Hayadri, Asep Komara Walkis, Hermin Pancasakti Kusumaningrum, and Anto Budiharjo. "Simulasi Blood Type Inheritance dengan Pemrograman Software Wolfram." Bioma : Berkala Ilmiah Biologi 24, no. 1 (June 13, 2022): 66–72. http://dx.doi.org/10.14710/bioma.24.1.66-72.

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Bioinformatics as an interdisciplinary science, combine biology, computer science, information technology, mathematics, and statistics in order to analyze and interprete biological data. Bioinformatics has been used for in silico analysis of biological questions using mathematical and statistical techniques. In silico analysis allows indirect simulation through a series of instructions put into a device, usually a computer. Nowadays, the simulation of biological aspects, especially genetics, with in silico method has been widely applied for several fields. The ABO blood type inheritance system in humans has rules that its mechanism can be applied into the Wolfram software programming, for example showing the possibility of blood groups being inherited from blood type O pairs with AB. The latest statistical data regarding the number of Indonesians who have reported their blood type has not yet reached 25% of the total population of Indonesia. Wolfram software is expected to be an accurate and fast blood type detector to record the entire population of Indonesia. The purpose of this study was to simulate Blood Type Inheritance with Wolfram Software Programming on ABO blood type inheritance data and see the suitability of the simulation results with real blood type inheritance data. The method used to simulate blood type inheritance is a survey of 12 families for the data of blood group, the next step is to enter the data one by one into the simulation model to observe the output results then matched with real data to determine the results of ABO blood type inheritance. Simulation of blood type inheritance can be done by programming the Wolfram Mathematica software and blood type data from 12 families can be simulated through the ABO blood inheritance system on Wolfram Mathematica, with details of the simulation predicting the blood groups of 2 families, simulation of 9 families according to real data, and simulation of 1 family does not match the real data.

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Jesch, Ursula, P. Christian Endler, Beatrix Wulkersdorfer, and Heinz Spranger. "ABO Blood Group. Related Investigations and Their Association with Defined Pathologies." Scientific World JOURNAL 7 (2007): 1151–54. http://dx.doi.org/10.1100/tsw.2007.133.

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The ABO blood group system was discovered by Karl Landsteiner in 1901. Since then, scientists have speculated on an association between different pathologies and the ABO blood group system. The aim of this pilot study was to determine the significance between different blood types of the ABO blood group system and certain pathologies. We included 237 patients with known diagnosis, blood group, sex, and age in the study. As a statistical method, the Chi-square test was chosen. In some cases, a significant association between the blood groups and defined diseases could be determined. Carriers of blood group O suffered from ulcus ventriculi and gastritis (X21 = 78.629, p <0.001), colitis ulcerosa and duodenitis (X21 = 5.846, p < 0.016), whereas male patients carrying blood group A tended to contract different types of tumours. In patients with intestinal tumours, females with blood group A were more likely to develop the pathology, whereas in males, the blood group O dominated. The development of cholelithiasis was found, above all, in patients with blood group O, which differed from other research where a correlation between this pathology and blood group A was found.

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Gassner, C., A. Schmarda, W. Nussbaumer, and D. Schonitzer. "ABO glycosyltransferase genotyping by polymerase chain reaction using sequence-specific primers." Blood 88, no. 5 (September 1, 1996): 1852–56. http://dx.doi.org/10.1182/blood.v88.5.1852.1852.

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Abstract Serological typing for the classical ABO blood groups is routinely performed using anti-A and anti-B antisera of polyclonal or monoclonal origin, which are able to distinguish four phenotypes (A, B, AB, and O). Modern molecular biology methods offer the possibility of direct ABO genotyping without the need for family investigations. Typing can be done with small amounts of DNA and without detection of blood group molecules on the surface of red blood cells. We developed a system of eight polymerase chain reactions (PCR) to detect specific nucleotide sequence differences between the ABO alleles O1, O2, A1, A2, and B. PCR amplification using sequence-specific primers and detection of amplification products by agarose gel electrophoresis is one of the fastest genotyping methods and is easy to handle. With our method we tested the A1,2BO1,2 genotypes of 300 randomly chosen persons out of a pool of platelet donors and found the results to be consistent with ABO glycosyltransferase phenotypes. We also identified a presumably new ABO allele, which may be the result of a crossing-over event between alleles O1 and A2.

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Анотація:

Serological typing for the classical ABO blood groups is routinely performed using anti-A and anti-B antisera of polyclonal or monoclonal origin, which are able to distinguish four phenotypes (A, B, AB, and O). Modern molecular biology methods offer the possibility of direct ABO genotyping without the need for family investigations. Typing can be done with small amounts of DNA and without detection of blood group molecules on the surface of red blood cells. We developed a system of eight polymerase chain reactions (PCR) to detect specific nucleotide sequence differences between the ABO alleles O1, O2, A1, A2, and B. PCR amplification using sequence-specific primers and detection of amplification products by agarose gel electrophoresis is one of the fastest genotyping methods and is easy to handle. With our method we tested the A1,2BO1,2 genotypes of 300 randomly chosen persons out of a pool of platelet donors and found the results to be consistent with ABO glycosyltransferase phenotypes. We also identified a presumably new ABO allele, which may be the result of a crossing-over event between alleles O1 and A2.

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Golovkina, L. L., R. S. Kalandarov, O. S. Pshenichnikova, V. L. Surin, A. G. Stremoukhova, T. D. Pushkina, G. V. Atroshchenko, O. S. Kalmykova, and B. B. Khasigova. "Polymorphism of ABO*O alleles and its clinical significance." Oncohematology 16, no. 4 (November 11, 2021): 83–89. http://dx.doi.org/10.17650/1818-8346-2021-16-4-83-89.

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Background. 62 ABO*O alleles of the ABO system are known. Some ABO*O alleles may be accompanied by the presence of residual A-glycosyltransferase activity in people of group O, which may lead to errors in determining the blood group. This confirms the important clinical significance of the ABO*O allele polymorphism. Knowledge of ABO*O gene polymorphisms and their prevalence contributes to the prevention of errors in determining the blood group of the ABO system.Objective: to study allele variants of the ABO*O gene in Russians.Materials and methods. The blood samples of 14,000 people were examined. The blood group was determined using anti-A, anti-Aweak, anti-B, lectin (anti-A1) and gel cards, as well as by cross-sectional method using standard red blood cells of O, A, and B groups. In one patient, the method of adsorption-elution with cold elution was used to identify a weak variant of antigen A, and the method of thermal elution was used to eliminate antigen- blocking plasma factors. Molecular determination of ABO*O alleles was performed in 130 individuals by polymerase chain reaction with sequence- specific primers and Sanger direct sequencing.Results. 13 allelic variants of the ABO*O gene were identified (10 with a typical deletion of c.261delG / N and 3 nondeletional alleles with polymorphism c.802G>A). Deletion alleles of ABO*O.01 were found in 92.85 % of the examined patients, nondeletion alleles of АВО*О.02 group – in 7.15 % of cases. The ABO*O.01.01 allele was detected with a frequency of 67.14 %, other deletion alleles – much less frequently: ABO*O.01.02 and ABO*O.01.11 – 5.71 %, ABO*O.01.26 – 5.00 %, ABO*O.01.12 – 4.30 %, ABO*O.01.13 and ABO*O.01.44 – 1.43 %, ABO*O.01.05, ABO*O.01.46, ABO*O.01.68 – 0.71 % each. Non-deletional alleles were found with the following frequencies: ABO*O.02.01 – 4.3 %, ABO*O.02.03 allele – 2.14 %, ABO*O.02.02 – 0.71 %. All individuals with the O group with the nondeletional allele had the Oαβ group, except for one patient (with the ABO*O.01.02 O.02.02 genotype), who had the Oβ group.Conclusion. For the first time, the immunogenetic characteristics of Russians are given according to ABO*O genes. Erythrocyte genomics helps to resolve the ambiguity of serological methods results and allows understanding mechanisms of different phenotypes formation. For the correct definition of natural isohemagglutinins and weak antigens variants should be used at least two different serological methods.

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Дисертації з теми "Blood groups ABO system Molecular aspects"

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies." Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb578.pdf.

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"May 2002" Includes bibliographical references (leaves 229-251) Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.

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Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies / Tina Bianco-Miotto." Thesis, Adelaide, S.A, 2002. http://hdl.handle.net/2440/21857.

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"May 2002"
Includes bibliographical references (leaves 229-251)
xv, 251 leaves : ill. (some col.) ; 30 cm.
Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2003

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Olsson, Martin L. "Molecular genetic studies of the blood group ABO locus in man." Lund : Dept. of Transfusion Medicine, Institute of Laboratory Medicine, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38985966.html.

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O'Keefe, Denise Susan. "Molecular analysis of changes in ABO blood group antigen expression in haematological malignancy / Denise S. O'Keefe." 1995. http://hdl.handle.net/2440/18642.

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Errata inserted on back end paper.
Bibliography: leaves 226-254.
xviii, 261 leaves : ill. ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
Describes the development of techniques to genotype and simultaneously assess allele dosage at the ABO locus using PCR and allele-specific restriction enzyme digestion.
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1996

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Книги з теми "Blood groups ABO system Molecular aspects"

Takahashi, Kōta. Accommodation in ABO-incompatible kidney transplantation. 2nd ed. Boston: Elsevier, 2004.

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Nomi, Toshitaka. Ketsuekigata omoshiro-dokuhon: Wadai no kakukai chomeijin no ketsuekigata saishin dēta tsuki. Tōkyō: Seishun Shuppansha, 1998.

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Xue xing jiao ji shu. Taibei Shi: Xin miao wen hua shi yeh yu xian gong si, 1995.

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Liufenyi. Xing zuo & xue xing mi ma wan quan da po jie. Xinbei shi: Du pin wen hua shi ye you xian gong si, 2011.

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Lucy, Degrémont, ed. The blood type diet cookbook. London: Thorsons, 2010.

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Ting jian xue xing de sheng yin: Che di liao jie A, B, AB, O xing de ren ge te zhi. Taibei Shi: Shang qi zi xun gu fen you xian gong si, 2014.

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Shui, Yanjun. Shi er xing zuo, xue xing x sheng xiao shen mi mi ma. Xinbei Shi: Da tuo wen hua shi ye you xian gong si, 2017.

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Xuexingdaren, ed. Chao zhun xue xing xing zuo da jie xi. Beijing: Zhongguo shang ye chu ban she, 2009.

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Xuexingdaren, ed. Chao shen zhun! 48 zhong xue xing xing zuo jie ma quan shu: Decoding the secrets of 48 blood types and constellations. Taibei Xian Zhonghe Shi: Qi si chu ban ji tuan, 2011.

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Suzuki, Yoshimasa. Nhóm máu và giao tirep nam nzu. Hà Nuoi: NXB Y học, 2004.

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