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Статті в журналах з теми "BioInorganic Chemistry, Medicinal Chemistry"
Nurchi, Valeria M., and Guido Crisponi. "Editorial: Applications of Medicinal Bioinorganic Chemistry." Current Medicinal Chemistry 25, no. 1 (January 22, 2018): 3–4. http://dx.doi.org/10.2174/092986732501180122141500.
Повний текст джерелаSchatzschneider, Ulrich. "Bioinorganic Medicinal Chemistry. Edited by Enzo Alessio." Angewandte Chemie International Edition 50, no. 46 (October 21, 2011): 10765–67. http://dx.doi.org/10.1002/anie.201104828.
Повний текст джерелаSchatzschneider, Ulrich. "Bioinorganic Medicinal Chemistry. Herausgegeben von Enzo Alessio." Angewandte Chemie 123, no. 46 (October 21, 2011): 10953–55. http://dx.doi.org/10.1002/ange.201104828.
Повний текст джерелаKostova, Irena. "Editorial to the Special Issue: “Synthesis of Organic Ligands and Their Metal Complexes in Medicinal Chemistry”." Molecules 27, no. 11 (June 6, 2022): 3644. http://dx.doi.org/10.3390/molecules27113644.
Повний текст джерелаCohen, Seth M. "New approaches for medicinal applications of bioinorganic chemistry." Current Opinion in Chemical Biology 11, no. 2 (April 2007): 115–20. http://dx.doi.org/10.1016/j.cbpa.2007.01.012.
Повний текст джерелаReedijk, Jan. "Bioinorganic chemistry." Science of Nature 74, no. 2 (February 1987): 71–77. http://dx.doi.org/10.1007/bf00366080.
Повний текст джерелаErxleben, Andrea. "Transition metal salen complexes in bioinorganic and medicinal chemistry." Inorganica Chimica Acta 472 (March 2018): 40–57. http://dx.doi.org/10.1016/j.ica.2017.06.060.
Повний текст джерелаRavichandran, S., R. M. Madhumitha Sri, Mahrukh Mehraj, and Chundru Sowmya. "The importance of transition metals as drug." International Journal of Clinical Biochemistry and Research 9, no. 1 (March 15, 2022): 1–3. http://dx.doi.org/10.18231/j.ijcbr.2022.001.
Повний текст джерелаNurchi, Valeria M. "Medicinal bio-inorganic chemistry: papers from the Third International Summer School of Bioinorganic Medicinal Chemistry, Cagliari, Italy." Journal of Inorganic Biochemistry 199 (October 2019): 110798. http://dx.doi.org/10.1016/j.jinorgbio.2019.110798.
Повний текст джерелаBhabak, Krishna P., Bhaskar J. Bhuyan, and Govindasamy Mugesh. "Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes." Dalton Transactions 40, no. 10 (2011): 2099. http://dx.doi.org/10.1039/c0dt01057j.
Повний текст джерелаДисертації з теми "BioInorganic Chemistry, Medicinal Chemistry"
Paiva, Raphael Enoque Ferraz de 1989. "Complexos metálicos com nimesulida : síntese, caracterização e aplicações em química bioinorgânica medicinal." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249124.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
Made available in DSpace on 2018-08-25T01:00:34Z (GMT). No. of bitstreams: 1 Paiva_RaphaelEnoqueFerrazde_M.pdf: 15807547 bytes, checksum: e13f0a8a3bbde08ba558ac7cdb13c9a5 (MD5) Previous issue date: 2014
Resumo: Complexos metálicos têm sido estudados quanto as suas propriedades medicinais há décadas. Neste trabalho, dois complexos inéditos de Ag(I) e Pt(II) foram sintetizados com o anti-inflamatório nimesulida (NMS), e avaliados como agentes antibacterianos e antitumorais. O complexo Ag-NMS (AgC13H11N2O5S) apresenta o ligante em uma coordenação bidentada à prata pelos átomos de N e O do grupo sulfonamida. A estrutura proposta foi confirmada por DFT. Devido à baixa solubilidade em água, foi preparado um complexo de inclusão de Ag-NMS em b-CD, pelo método de co-evaporação. Utilizando o método de Scatchard, foi determinado o valor de Ka = 370 2 L mol. Estudos de RMN por correlação H-H através do espaço mostram que a inclusão ocorre pelo grupo fenoxi da NMS. Já o complexo Pt-NMS (PtC26H22N4O10S2) apresenta dois ligantes, coordenados pelos átomos de N e O do grupo sulfonamida, para cada Pt(II). A DFT indica que o isômero N, O trans é o mais estável. O complexo Ag-NMS apresentou valores de MIC na faixa de 15,0-120 mmol L sobre cepas de Pseudomonas aeruginosa, Escherichia col e Staphylococcus aureus. O CE-[(Ag-NMS)·b-CD], embora mais solúvel em água do que o Ag-NMS, não apresentou atividade antibacteriana nas concentrações testadas. Os complexos Ag-NMS e Pt-NMS mostraram-se citotóxicos sobre células normais (Balb/c 3T3) e tumorais (SK-Mel 103 e Panc-1), porém o Pt-NMS foi significativamente mais seletivo contra as linhagens tumorais. Os ensaios de intercalação com EtBr e a avaliação da estrutura do DNA por dicroísmo circular indicam que o DNA não é um alvo biológico para o complexo Pt-NMS, indicando um mecanismo de ação diferente da cisplatina
Abstract: Metal complexes have been studied regarding its medicinal properties for decades. In this work, novel complexes of Ag(I) and Pt(II) with the anti-inflammatory nimesulide were synthesized and evaluated regarding their antibacterial and antitumoral properties. The Ag-NMS complex (AgC13H11N2O5S) shows the ligand in a bidentate coordination mode, bound to silver through the N and O atoms of the sulfonamide group. The proposed structure was confirmed by DFT. Due to its poor solubility in water, the Ag-NMS complex was included in b-CD, by co-evaporation. The Ka = 370 2 L mol was determined using the Scatchard method. Studies by H-H NMR correlation through space shows the inclusion of NMS by the fenoxi group. The Pt-NMS complex (PtC26H22N4O10S2) contain two ligands, coordinated through the N and O atoms of the sulfonamide group, for each Pt(II). DFT studies indicate that the N,O trans isomer is the most stable. The Ag-NMS complex presents MIC values in the range 15.0-120 mmol L over Pseudomonas aeruginosa, Escherichia coli e Staphylococcus aureus. The inclusion complex CE-[(Ag-NMS)·b-CD], although more soluble in water than Ag-NMS, shows no antibacterial activity in the tested concentrations. Both complexes were cytotoxic against normal (Balb/c 3T3) and tumor (SK-Mel 103 and Panc-1) cells, but the Pt-NMS complex was significantly more selective against tumor cells. The EtBr competitive intercalation assay and the evaluation of CT-DNA structure using circular dichroism show that DNA is not a biological target for the Pt-NMS complex, indicating a mechanism of action different of the cisplatin one
Mestrado
Quimica Inorganica
Mestre em Química
Karges, Johannes. "Design, Synthèse, Caractérisation et Evaluation Biologique de Complexes Métalliques pour la Thérapie Photodynamique à un et deux Photons." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEC028.
Повний текст джерелаCancer is and remains a major health problem all around the world. Statistics over the last decades of GLOBOCAN and WHO shows that it is the leading cause of death in developed countries and the second most lethal disease in non-developed countries. It is suggested that the increasing impact of cancer on the life expectation and life quality in developed countries is a result of population aging and growth and adoption of an unhealthy life style such as for example smoking or physical inactivity. While the number of reported patients diagnosed with cancer is from year to year rising, significant improvements in the treatment and life expectations of patients were made. To date, cancer is commonly treated by surgery, chemotherapy, immunotherapy, radiotherapy or a combination of these to overcome the limitations of a single treatment. To attenuate the side effects of such treatments and to increase the overall survival of the patient, much research efforts are currently devoted towards the development of new therapeutic strategies and drugs. Recently, photodynamic therapy (PDT) has received increasing attention as a complementary technique for the treatment of a variety of cancers. During a therapeutic session, a photoactivable drug is administered to a patient. Afterward, this drug is locally activated upon light exposure. Despite the success of the currently approved drugs, the ability of these are limited, among others, due to their poor biological stability, solubility and cancer selectivity. To overcome these limitations, in this work, different types of new metal complexes were investigated as potential drug candidates
Keter, Frankline Kiplangat. "Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&.
Повний текст джерелаPettenuzzo, Nicolò. "Steps forwards to a new type of oncotherapy: from the solution chemistry of Au(III)-dithiocarbamato complexes to the design and development of innovative Au(III)- and Cu(II)-based cancer-targeting agents." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426685.
Повний текст джерелаAl fine di superare gli effetti collaterali della chemioterapia, ma rimanendo fortemente convinti del ruolo potente che può svolgere la chimica inorganica applicata alla medicina, la Prof.ssa Fregona e i suoi collaboratori si sono occupati, fin dai primi anni 2000, dello sviluppo di una serie di molecole a base metallica con leganti ditiocarbammici, in particolare contenenti centri metalli quali Au(III), Ru(III) e Cu(II). Queste si sono rivelate altamente attive in vitro verso un gran numero di linee cellulari tumorali umane e meno tossiche, in vivo, rispetto ad altri chemioterapici di uso clinico. Benchè negli ultimi anni siano stati condotti diversi studi approfonditi sulla chimica di questi potenti composti di coordinazione, alcuni aspetti rimangono ancora da spiegare. Nella prima parte di questo lavoro, si presenta uno studio completo sulla sintesi, la caratterizzazione e sulla chimica in soluzione di otto complessi ditiocarbammici di Au(III), che hanno rivelato una reattivià peculiare ed affascinante. Inoltre, sette di essi hanno dimostrato interessanti proprietà biologiche in vitro verso una linea cellulare tumorale del cancro colon-rettale. Nella seconda parte del progetto di dottorato, il lavoro si è focalizzato sulla sintesi, la caratterizzazione e la valutazione biologica di nuovi complessi ditiocarbammici di Au(III) e Cu(II), bioconiugati con una funzione molecolare targettante, con l'obiettivo di migliorare l’accumulo di questa classe di molecole all’interno delle cellule cancerose. Al fine di raggiungere questo obiettivo, sono stati scelti tre differenti agenti di targeting, che sfruttano il diverso metabolismo delle cellule neoplastiche rispetto a quelle sane. Nel complesso, sono stati sintetizzati nove diversi composti di coordinazione che sono stati testati come agenti antitumorali in vitro. Fra questi, uno di loro ha dimostrato un'elevata attività citotossica contro una linea cellulare tumorale, aprendo la strada a futuri studi che indagheranno il ruolo della funzionalizzazione targettante nel delivery selettivo del complesso verso i tessuti cancerosi.
PAIOTTA, ALICE. "Synthesis of Glycoderivatives as Molecular Tools in Medicinal Chemistry and Nano-Medicinal Chemistry." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199137.
Повний текст джерелаThe project carried out during the 3 years-Ph.D. has had the objective to identify and synthesize new glycomimetics as molecular tools to study the Hexosamine Biosynthetic Pathway (HBP), which role is to regulate the proliferation and survival of cancer cells. The project has been funded by AIRC and the principal aim was to identify the Adenocarcinoma of the Pancreatic Duct (PDAC) as the target of research. The synthesis of innovative chemical tools helps the understanding of the HBP pathway and its response in PDAC: new potential inhibitors, which are similar to the natural substrate of enzyme, can be recognized but trick the enzyme and block its activity in order to decrease the UDP-GlcNAc production and consequently modify the protein glycosylation. Due to the important role of the HBP in the cells, alteration of this pathway can bring to alteration of N- and O- glycosylation and activate the Unfolded Protein Response (UPR) during the Endoplasmic Reticulum (ER) stress. The description of the research target helps the understanding of the design of molecular tools: the focus point is the inhibition of the enzyme N-acetylglucosamine-phosphate mutase (AGM1): its inhibition could represent the way to induce apoptosis in cancer cells. Through the Molecular Design, a rational design of potential inhibitors has been done. This design is based on the similarity with the structures of the natural substrate of enzyme AGM1, with some modifications. All of the drawn structures have been used for Molecular Docking in order to get a first virtual screening on the compounds library. Starting from preliminary results of theoretical approach, the synthesis of compounds have been done following three different synthetic strategies. All the steps and reaction condition are described in details and are shown the characterization (1H, 13C NMR spectra, m/z) of all the synthetized compound. The optimization of the analytical method on High Performance Liquid Chromatography is necessary in order to achieve experimental data on the ability of the designed compounds to inhibit the target enzyme, data to be compared to those obtained through a computational theoretical approach. To this aim an HPLC method has been set-up for the quantification of UDP-GlcNAc produced using the cellular extract as enzyme source, and carrying out the reaction with the natural substrates GlcNAc-6P, UTP in the presence or not of the test molecules. Using 10 and 30 µL of extract, three compounds lead to a decrease of production of UDP-GlcNAc. The computational data ”describes” the interaction between the enzyme and the molecules. The calculation of C LogP has confirmed the most apolar character of compound 3B in the acetylated form. Some preliminary evaluation of the effect of compound 2B in a Triple Negative Breast Cancer (TNBC) cell model has been carried out. In conclusion, the study of the target of this research, the HBP pathway, and the focus on the inhibition of AGM1 are the starting point for a complete project, that includes at first the design of a library of compound based on the structural properties of the natural substrate. the “in silico” evaluation of their interaction with the target enzyme, the synthesis and the screening through an enzymatic assay.. The tuning of the strategy of synthesis is important to obtain the compound for the in vitro test. The analytical method with HPLC gives results comparable to the docking scores, and then, after a calculation of C LogP, the test on cells gives the final results of potency of compound 3B (2B the acetylated form). The last part describes the collaboration with CycloLab (Budapest): some compounds of the library possess chemical-physical characteristics that make their passage through cell membrane very harsh: they are very polar and some of them possess negative charges (sulphate, sulphonates, phosphoramidate). This preliminary work is still in progress.
Brophy, Megan Brunjes. "Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98823.
Повний текст джерелаVita. Cataloged from PDF version of thesis.
Includes bibliographical references.
The human innate immune system responds to bacterial and fungal pathogens by releasing the metal-chelating protein calprotectin (CP) at sites of infection and in the upper layers of the epidermis. CP is a Mn(II)- and Zn(ll)-binding protein. The work described in this thesis elucidates the metal-binding properties of CP, and correlates these properties with in vitro growth inhibition of bacteria and fungi. We report that the metal-binding properties of CP are modulated by Ca(ll), and we propose a working model in which CP responds to physiological Ca(Il)-ion gradients to become a potent Zn(ll)- and Mn(Il)-chelating agent in the extracellular space. Individual chapter summaries follow. Chapter 1: Bioinorganic Chemistry of the Host Pathogen Interaction. Transition metal ions are required for all forms of life. During the course of infection, pathogenic microorganisms must acquire transition metals from the host. Three metals of interest from this standpoint are iron, zinc, and manganese. This chapter describes bacterial metal-ion homeostasis machineries, and metal-requiring processes with a focus on Zn(II) and Mn(II). This chapter then highlights the S100 family of Ca(ll)-binding proteins and discuses the Zn(Il)-, Cu(ll)-, and Mn(Il)-binding properties of S100B, S100A12, S100A7, S10OA15, and S100A8/S100A9. Finally, an overview of the scope of this thesis is presented. Chapter 2: Calcium Ion Gradients Modulate the Zinc(Il) Affinity and Antibacterial Activity of Human Calprotectin. Calprotectin (CP) is a human neutrophil protein that is produced and released by neutrophils at sites of infection, where it prevents the growth of microorganisms by sequestering bioavailable zinc(II) and manganese(II). In this chapter, we present metalbinding studies to elucidate the Zn(ll)-binding properties of CP. We report unique optical absorption and EPR spectroscopic signatures for the interfacial His 3Asp and His 4 sites of human CP by using Co(II) as a spectroscopic probe. Zinc competition titrations employing colorimetric and fluorimetric Zn(II) sensors establish that CP coordinates two Zn(II) ions / CP heterodimer. The Ca(ll)-insensitive Zn(ll) sensor ZP4 is used to determine the Kd of CP for Zn(II) in Ca(Il)-deplete and Ca(Il)-replete conditions. These competition titrations afford apparent Kdsitel = 133 58 pM and Kdsite2 = 185 219 nM in the absence of Ca(II). In the presence of excess Ca(Il) these values decrease to Kd,sitel 5 10 pM and Kd,site2 : 240 pM. In vitro antibacterial assays indicate that the metal-binding sites and Ca(ll)-replete conditions are required to inhibit the growth of Gram-negative and Gram-positive bacteria. We propose a model in which Ca(II) ion gradients modulate the antibacterial activity and Zn(Il)-binding properties of human CP. Chapter 3: High-Affinity Manganese Coordination by Human Calprotectin Is Calcium- Dependent and Requires the Histidine-Rich Site at the Dimer Interface. In this chapter, we report that the His 4 motif at the S10OA8/S100A9 dimer interface of CP is required for high-affinity Mn(II) coordination. We identify a low-temperature EPR spectroscopic signal for this site that is consistent with high-spin Mn(II) in an octahedral coordination sphere. This site could be simulated with zero-field splitting parameters D = 270 MHz and EID = 0.30 (E = 81 MHz). This analysis, combined with studies of mutant proteins, suggests that (A8)Hisl7, (A8)His27, (A9)His9l, (A9)His95 and two as-yet unidentified ligands coordinate Mn(ll) at site 2. These studies support a model in which CP responds to Ca(ll) ion gradients to become a potent metal-ion chelator in the extracellular space. Chapter 4: Contributions of the C-terminal Tail of S100A9 to High-Affinity Manganese Binding by Human Calprotectin. This chapter examines the role of the S100A9 C-terminal tail to high-affinity Mn(ll) coordination by human CP. We present a 16-member mutant family with mutations in the S100A9 C-terminal tail (residues 96-114), which houses three histidine and four acidic residues, to evaluate its contribution to Mn(ll) sequestration. These studies confirm that two His residues at positions 103 and 105 complete the octahedral coordination sphere of CP in solution. Appendix 1: Sequence Alignments of Transition-Metal Binding S100 Proteins. Sequence alignments of S100A7, S100A8, S100A9, S100A12, S100A15, and S100B proteins from multiple organisms are presented. Appendix 2: Characterization of CP Mutant Proteins by Circular Dichroism and Analytical Size Exclusion Chromatography. Additional characterization of CP and mutant proteins employed in Chapters 2-4 is presented. Appendix 3: Structures of Sensors Used In this Work. The structures of Zincon, MagFura-2, Zinpyr-1, and Zinpyr-4 are presented. Appendix 4: Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium. This appendix represents a collaborative work with the Drennan Lab (MIT) and Britt Lab (UC Davis) to study the Mn(Il)-CP complex in low- and high-Ca(II) conditions. We report a crystal structure of Mn(Il)-, Ca(Il)-, and Na(l)-bound CP with Mn(II) exclusively coordinated to the His6 motif. Electron spin-echo envelope modulation and electron-nuclear double resonance experiments demonstrate that the six coordinating histidine residues are spectroscopically equivalent. The observed 15N ( = %/h)y perfine couplings (A) arise from two distinct classes of nitrogen atoms: the coordinating E-nitrogen of the imidazole ring of each histidine (A = [3.45, 3.71, 5.91] MHz) and the distal 6-nitrogen (A = [0.11, 0.18, 0.42] MHz). In the absence of Ca(II), the affinity of CP for Mn(II) drops by two to three orders of magnitude, and Mn(II) coordinates to the His6 site as well as other sites on the protein.
by Megan Brunjes Brophy.
Ph. D. in Biological Chemistry
Uchiyama, Mayara Klimuk. "Estudo de nanopartículas de ouro e de magnetita voltadas para medicina diagnóstica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-18092015-104822/.
Повний текст джерелаTheranostics has been intensively pursued in recent years using hybrid materials based on nanoparticles conjugated with biomolecules. This is an interesting strategy to increase the selectivity and sensitivity, as well as to improve the currently used methods facilitating their use or creating new ones. Among the various types of nanomaterials, those based on gold and magnetic nanoparticles exhibit interesting chemical and physical properties in the biological environment, differing from that of free drugs or current explored in assay methods. For example, superparamagnetic nanoparticles are excellent contrast agents for magnetic resonance image (MRI) diagnostics because they are safer, present a better contrast efficiency for imaging and can be magnetically accumulated in tissues or tumors using a magnetic field. Numerous in vitro and in vivo toxicity assays were performed to ensure the safety for medical applications. Clearly, these type of applications only will be realized if nanomaterials prove to be nontoxic and biocompatible. This imply an strict control on their structure and composition. However, despite the significant advances in the development of such nanomaterials, there were not found in the literature model systems explaining or that can be used to predict by which sites the protein-nanoparticle binding should take place. In addition, no systematic studies on the factors determining the stability and the functionality of nanobioconjugates (NBC) were found. Thus, this thesis is focused in unveiling the factors responsible for binding/adsorption of proteins on gold nanoparticles and their influence on the colloidal stability of hybrid nanoparticles suspensions while keeping the functionality of biomolecules. In fact, NBC with enhanced properties suitable for the development of diagnostic methods and even for treatment of diseases were obtained. These nanomaterials can improve the ELISA immunoassay, or other diagnosis methods can be developed by using the gold nanoparticles plasmonic properties in association with SERS, SPR and confocal Raman microscopy techniques.
Rajarathinam, Kayathri. "Nutraceuticals based computational medicinal chemistry." Licentiate thesis, KTH, Teoretisk kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-122681.
Повний текст джерелаQC 20130531
Pujar, P. P. "Chemistry of Indian medicinal plants." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1999. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3410.
Повний текст джерелаYan, Siu-cheong. "Bioinorganic chemistry of antimony : interaction of antimonial with biomolecules /." View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30575540.
Повний текст джерелаКниги з теми "BioInorganic Chemistry, Medicinal Chemistry"
Alessio, Enzo, ed. Bioinorganic Medicinal Chemistry. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.
Повний текст джерелаBioinorganic medicinal chemistry. Weinheim, Germany: Wiley-VCH Verlag GmbH, 2011.
Знайти повний текст джерелаB, Goodenough J., Ibers J. A, Jørgensen C. K, Mingos D. M. P, Neilands J. B, Palmer G. A, Reinen D, Sadler P. J, Weiss Ronald 1937-, and Williams R. J. P, eds. Bioinorganic Chemistry. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988.
Знайти повний текст джерелаLong, Eric C., and Michael J. Baldwin, eds. Bioinorganic Chemistry. Washington, DC: American Chemical Society, 2009. http://dx.doi.org/10.1021/bk-2009-1012.
Повний текст джерелаKessissoglou, Dimitris P., ed. Bioinorganic Chemistry. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1.
Повний текст джерелаPhilip, Aisen, ed. Bioinorganic chemistry. Berlin: Springer-Verlag, 1988.
Знайти повний текст джерелаIvano, Bertini, ed. Bioinorganic chemistry. Berlin: Springer-Verlag, 1995.
Знайти повний текст джерела1953-, Bill E., ed. Bioinorganic chemistry. Berlin: Springer-Verlag, 1991.
Знайти повний текст джерелаIvano, Bertini, ed. Bioinorganic chemistry. Mill Valley, Calif: University Science Books, 1994.
Знайти повний текст джерелаA, Armstrong Fraser, ed. Bioinorganic chemistry. Berlin: Springer-Verlag, 1990.
Знайти повний текст джерелаЧастини книг з теми "BioInorganic Chemistry, Medicinal Chemistry"
Farrer, Nicola J., and Peter J. Sadler. "Medicinal Inorganic Chemistry: State of the Art, New Trends, and a Vision of the Future." In Bioinorganic Medicinal Chemistry, 1–47. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch1.
Повний текст джерелаCrossley, Ellen L., H. Y. Vincent Ching, Joseph A. Ioppolo, and Louis M. Rendina. "Boron and Gadolinium in the Neutron Capture Therapy of Cancer." In Bioinorganic Medicinal Chemistry, 283–305. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch10.
Повний текст джерелаMawani, Yasmin, and Chris Orvig. "Essential Metal Related Metabolic Disorders." In Bioinorganic Medicinal Chemistry, 307–50. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch11.
Повний текст джерелаGasser, Gilles, and Nils Metzler-Nolte. "Metal Compounds as Enzyme Inhibitors." In Bioinorganic Medicinal Chemistry, 351–82. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch12.
Повний текст джерелаRuggi, Albert, David N. Reinhoudt, and Aldrik H. Velders. "Biomedical Applications of Metal-Containing Luminophores." In Bioinorganic Medicinal Chemistry, 383–406. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch13.
Повний текст джерелаNorman, Julia F., and Trevor W. Hambley. "Targeting Strategies for Metal-Based Therapeutics." In Bioinorganic Medicinal Chemistry, 49–78. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch2.
Повний текст джерелаDhar, Shanta, and Stephen J. Lippard. "Current Status and Mechanism of Action of Platinum-Based Anticancer Drugs." In Bioinorganic Medicinal Chemistry, 79–95. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch3.
Повний текст джерелаWang, Xiaoyong, and Zijian Guo. "New Trends and Future Developments of Platinum-Based Antitumor Drugs." In Bioinorganic Medicinal Chemistry, 97–149. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch4.
Повний текст джерелаBratsos, Ioannis, Teresa Gianferrara, Enzo Alessio, Christian G. Hartinger, Michael A. Jakupec, and Bernhard K. Keppler. "Ruthenium and Other Non-Platinum Anticancer Compounds." In Bioinorganic Medicinal Chemistry, 151–74. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch5.
Повний текст джерелаBoccarelli, Angela, Alessandra Pannunzio, and Mauro Coluccia. "The Challenge of Establishing Reliable Screening Tests for Selecting Anticancer Metal Compounds." In Bioinorganic Medicinal Chemistry, 175–96. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.ch6.
Повний текст джерелаТези доповідей конференцій з теми "BioInorganic Chemistry, Medicinal Chemistry"
Benito, Elena, Rocío Recio, Belén Begines, Victoria Valdivia, Lorenzo Gabriel Borrego, Lucía Romero-Azogil, Ana Alcudia, et al. "CASE STUDY: MEDICINAL CHEMISTRY." In 10th annual International Conference of Education, Research and Innovation. IATED, 2017. http://dx.doi.org/10.21125/iceri.2017.1425.
Повний текст джерелаMadzhidov, T., A. Fatykhova, V. Afonina, A. Sizov, R. Nugmanov, and A. Varnek. "CHEMOINFORMATICS MEETS SYNTHETIC MEDICINAL CHEMISTRY." In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-173.
Повний текст джерелаGlass, Jennifer. "Planetary Metabolism: Linking Solid Interiors to Gaseous Biosignatures via Bioinorganic Chemistry." In Goldschmidt2021. France: European Association of Geochemistry, 2021. http://dx.doi.org/10.7185/gold2021.6279.
Повний текст джерелаChou, Kuo-Chen. "Trends in Medicinal Chemistry." In MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/mol2net-03-04615.
Повний текст джерелаSousa, M. Emília, M. Matilde Marques, and M. Amparo F. Faustino. "1st Spring Virtual Meeting on Medicinal Chemistry." In Stand Alone Papers 2021. Basel Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/chemproc2021004001.
Повний текст джерелаLoureiro, Daniela R. P., José X. Soares, Cláudia Nunes, Carlos M. M. Afonso, and Salette Reis. "Optimization of Lipid-Based Ceftriaxone Delivery System via Machine Learning." In International Electronic Conference on Medicinal Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13415.
Повний текст джерелаde Melo, Rebeca Muniz, Gabriela Marques Albuquerque, Giovannia Araújo de Lima Pereira, and Maria Goreti Carvalho Pereira. "Bimodal Nanoprobes Containing Hydrophilic Quantum Dots and Paramagnetic Chelates." In International Electronic Conference on Medicinal Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13307.
Повний текст джерелаPopa, Veronica, Sorin Avramescu, and Miruna Silvia Stan. "Extraction of Anthocyanins from Black Currants and In Vitro Testing for the Determination of Antioxidant Activity." In International Electronic Conference on Medicinal Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13146.
Повний текст джерелаSokol, Maria, Ivan Gulyaev, Mariia Mollaeva, Sergey Kuznetsov, Vladimir Zenin, Maksim Klimenko, Nikita Yabbarov, Margarita Chirkina, and Elena Nikolskaya. "Box–Behnken Assisted HPLC Development of Simultaneous Determination of Doxorubicin and Vorinostat Encapsulated into Polymeric Nanoparticles." In International Electronic Conference on Medicinal Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13493.
Повний текст джерелаGarala, Kevinkumar, and Parag Rabara. "Development of In Situ Gel Containing Phytoconstituents for the Treatment of Mouth Ulcers." In International Electronic Conference on Medicinal Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13438.
Повний текст джерелаЗвіти організацій з теми "BioInorganic Chemistry, Medicinal Chemistry"
Raymond, Kenneth N. Marine Bioinorganic Chemistry Workshop Held in Heron Island on 28 June - 2nd July 1989. Fort Belvoir, VA: Defense Technical Information Center, February 1990. http://dx.doi.org/10.21236/ada218348.
Повний текст джерелаDrury, Owen Byron. Development of High Resolution X-Ray spectrometers for the Investigation of Bioinorganic Chemistry in Metalloproteins. Office of Scientific and Technical Information (OSTI), January 2007. http://dx.doi.org/10.2172/957593.
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