Готові списки джерел за темами / Bio medicine

Добірка наукової літератури з теми "Bio medicine"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 7 вересня 2023

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Статті в журналах з теми "Bio medicine"

Chen, Luonan, and Jiarui Wu. "Bio-network medicine." Journal of Molecular Cell Biology 7, no. 3 (June 2015): 185–86. http://dx.doi.org/10.1093/jmcb/mjv038.

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Öberg, P. Åke. "Bio-optics in medicine." Medical & Biological Engineering & Computing 41, no. 3 (May 2003): 241. http://dx.doi.org/10.1007/bf02348426.

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Sun, Guan-Cheng. "Qigong: Bio-Energy Medicine." Journal of Alternative and Complementary Medicine 14, no. 8 (October 2008): 893. http://dx.doi.org/10.1089/acm.2008.0231.

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YAO, HUIYING, CHENGZHI JIN, JINGXIA ZHANG, and BENJIE WU. "BIO-PIXE AND BIO-SXRF." International Journal of PIXE 06, no. 01n02 (January 1996): 367–73. http://dx.doi.org/10.1142/s0129083596000399.

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Application of PiXE On biology, medicine and environment has been successful in the last twenty years. However, with the development of science and technique, lower detectable limit, sub-ppm sensitivity, more accurate quantitative analysis and the element chemical state information were presented which can not be achieved by PIXE. The synchrotron radiation as an excitation source to induce X-ray emission (SXRF) is a very powerful method with all the above requirements. In this paper the advantages of SXRF were discussed and compared with PIXE. The article shows our work on biological field by PIXE and SXRF also.

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Choi, Eugene J., John J. Lewin, and Geoffrey S. F. Ling. "Battlefield medicine: disrupting (bio)pharmaceutical production." Pharmaceutical Bioprocessing 3, no. 5 (September 2015): 361–69. http://dx.doi.org/10.4155/pbp.15.17.

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Kim, Ju Han. "Genomic Medicine and Bio-Medical Informatics." Journal of Korean Society of Medical Informatics 9, no. 2 (2003): 79. http://dx.doi.org/10.4258/jksmi.2003.9.2.79.

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Li, Cheng. "Potentiation of Bio Repositories In Personalized Medicine: Tumor Cells Establishment." Cancer Research and Cellular Therapeutics 1, no. 1 (December 8, 2017): 01–03. http://dx.doi.org/10.31579/2640-1053/003.

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The introduction of three-dimensional (3D) tumor cultures has revolutionized anticancer drug research as these cultures allow for the study of drug resistance mechanisms that cannot be explored in traditional two dimensional (2D) monolayer cultures. Discoveries in the 3D tumor culture field suggest that individualized drug sensitivity testing of solid tumor specimens through the establishment and use of 3D tumor cell cultures following tissue collection will become a routine service offered by modern tissue repositories as they expand from their traditional research role to active participation in personalized medicine. Unfortunately, most information related to 3D tumor cultures comes from studies using established tumor cell lines rather than primary tumor cultures. However, accumulation of genetic aberrations in cancer cell lines occurs with increasing number of passages severely limiting their usefulness for personalized medicine. There is only very limited information available concerning technologies and standard operating procedures for the efficient and routine isolation and processing of primary tumor cells for the establishment of 3D tumor cultures from solid tumor specimens. The purpose of this work was to review experimental data from the literature that may provide relevant information concerning the isolation and processing of primary tumor cells for the establishment of 3D tumor cultures. Information reviewed here may help bio repositories in the development and standardization of technologies and standard operating procedures related to the use of 3D tumor cultures.

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Kim, Jihyun, and Jungho Kim. "The vision of Korean Medicine industry with Bio-Information Technology." Korean Society of Human and Nature 3, no. 2 (December 30, 2022): 189–202. http://dx.doi.org/10.54913/hn.2022.3.2.189.

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With the development of bio-information technology, various bio-data are being produced, and research to analyze these data is being actively conducted. As it moves toward an aging society, the importance of prevention along with treatment is increasingly being emphasized. In this trend, the combined research of bio-information technology and Korean medicine can greatly contribute to improving the quality of people’s lives. This paper introduced changes in the paradigm of bio-information technology and the medical industry and examined the direction of convergence research according to future collaboration. Therefore, by examining the practical applicability of bio-information technology and Korean medicine, we discussed the necessity of constructing, refining, analyzing, and systemizing Korean medicine data to generalize theories that have not yet been clarified in Korean medicine based on experience. Finally, we looked at the present status, vision, and prospects of research currently underway in preparation for the spread of the Korean medical industry in the aging era.

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Shatokhina, S. N., V. N. Shabalin, M. E. Buzoverya, and V. T. Punin. "Bio-Liquid Morphological Analysis." Scientific World JOURNAL 4 (2004): 657–61. http://dx.doi.org/10.1100/tsw.2004.118.

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Information is presented on the new scientific line in medicine and biology: bio-liquid morphology. The interdisciplinary character of the given research area is emphasized. The problems and prospects of bio-liquid morphological analysis development both in applied and fundamental aspects are discussed.

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An, G., Dong Ying Ju, Pei Bian, T. Kumazawa, and M. Okasabe. "Bio-Medicine Coating on Surface of Magnetic Nanoparticles and its Safety Evaluation." Materials Science Forum 675-677 (February 2011): 303–6. http://dx.doi.org/10.4028/www.scientific.net/msf.675-677.303.

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The composite magnetic nanoparticles of coated SiO nano film with about 8 nm size can be dispersed in various liquid media, widely known as magnetic fluids or ferrofluids with both magnetic and liquid properties. In this paper, a bio-medicine coating technology on surface of magnetic nanoparticles and the optimum fabrication condition and the magnetism of composed bio-nanoparticles are investigated. Through observation of micro-structure of the bio-nanopaticles on coating surface, and evaluation of magnetic property and safety to apply to biomaterials, we know the bio-medicine coated on surface of magnetic nanoparticles is suitable of bio-solutions into surface of biomaterials.

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Більше джерел

Дисертації з теми "Bio medicine"

Martella, Elisa <1984&gt. "Mesenchymal stromal cell: new applications for regenerative medicine." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5440/1/Martella_Elisa_tesi.pdf.

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In the last decades mesenchymal stromal cells (MSC), intriguing for their multilineage plasticity and their proliferation activity in vitro, have been intensively studied for innovative therapeutic applications. In the first project, a new method to expand in vitro adipose derived-MSC (ASC) while maintaining their progenitor properties have been investigated. ASC are cultured in the same flask for 28 days in order to allow cell-extracellular matrix and cell-cell interactions and to mimic in vivo niche. ASC cultured with this method (Unpass cells) were compared with ASC cultured under classic condition (Pass cells). Unpass and Pass cells were characterized in terms of clonogenicity, proliferation, stemness gene expression, differentiation in vitro and in vivo and results obtained showed that Unpass cells preserve their stemness and phenotypic properties suggesting a fundamental role of the niche in the maintenance of ASC progenitor features. Our data suggests alternative culture conditions for the expansion of ASC ex vivo which could increase the performance of ASC in regenerative applications. In vivo MSC tracking is essential in order to assess their homing and migration. Super-paramagnetic iron oxide nanoparticles (SPION) have been used to track MSC in vivo due to their biocompatibility and traceability by MRI. In the second project a new generation of magnetic nanoparticles (MNP) used to label MSC were tested. These MNP have been functionalized with hyperbranched poly(epsilon-lysine)dendrons (G3CB) in order to interact with membrane glycocalix of the cells avoiding their internalization and preventing any cytotoxic effects. In literature it is reported that labeling of MSC with SPION takes long time of incubation. In our experiments after 15min of incubation with G3CB-MNP more then 80% of MSC were labeled. The data obtained from cytotoxic, proliferation and differentiation assay showed that labeling does not affect MSC properties suggesting a potential application of G3CB nano-particles in regenerative medicine.

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Carlino, Olga <1999&gt. "Some Aspects of Religious Spirituality in Medicine An Investigation Into the Dialogue between Biomedicine and Tibetan Medicine via Christianity and Buddhism." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21905.

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Among all the disciplines in which local medicine and spirituality are still intricately entangled, there exists one, namely Tibetan medicine. These medical knowledge and practices are also known as Sowa Rigpa gso ba rig pa, which can literally translate to the “science of healing” or the “Tibetan knowledge of the field of healing”. It is based on two essential elements: local medicine and Buddhism. These two coexist together and are both pivotal to treating the patient’s imbalance or illness. Inspired by Tibetan medical tradition, this thesis proposes research on some aspects concerning the connection between medicine and religion. Despite the abundant scientific literature available about Sowa Rigpa and other medicines and religions such as Ayurvedic medicine and Indian Buddhism, there are no studies investigating the relationship between biomedicine and Sowa Rigpa that took into consideration the medical dimension and religious contexts of each practice, i.e. Buddhism and Christianity. This experimental and interdisciplinary thesis aims at investigating the dialogue between these two coexisting worlds in order to highlight the contribution of spirituality as a complementary and supportive element to accept and confront an illness. During hundreds of years, Christianity as well as Buddhism had a strong influence on the development of medicine. Although this is no longer the case, it is yet possible for biomedicine and Christianity to keep interacting together, as demonstrated by Tibetan medicine and Buddhism. Therefore, I ultimately decided to examine the connection between biomedicine and religion in the Trompone complex in Moncrivello, in the province of Vercelli (in Piedmont), which brings together both the medical facilities and the Catholic Sanctuary devoted to “Beata Vergine del Trompone”. Apart from standard pharmacological treatments, patients can benefit from religious services and spiritual support. Most of the investigative work with patients, health and social professionals and spiritual caregivers was conducted in this medical center. By adopting an anthropological approach, this essay attempted to contribute to the dialogue between biomedicine and Sowa Rigpa via Christianity and Buddhism.

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Partington, Lee Ian. "Molecular wire based bio-electrochemical sensing systems." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:15133.

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This thesis aims to develop rapid, quantitative point of care sensing systems that exploit molecular wire platforms to enable the electrochemical detection of multiple target biomarkers, thereby empowering new technologies for the diagnosis of various medical conditions. Accordingly, the first chapter provides an overview of clinically important biomarkers for pregnancy and cardiovascular disease. The second chapter of this thesis details the electrochemical concepts underpinning subsequent chapters, with the third chapter providing an experimental overview. The first two research chapters develop a nano-structured, molecular wire platform based on diazonium salt electrochemistry coupled with immobilisation of antibodies conjugated to a suitable electroactive label. Here, the abundance of amine functionalities present at the antibody paratope enable the statistically large number of redox tags to be present at the antibody-antigen binding site, empowering the exquisitely selective and strong affinity of the antibody for a suitable antigen to be monitored quantitatively, through assessing the extent with which the redox labels are partially blocked in the presence of the antigen. In Chapter 4, experiments are contrasted with bespoke theory developed in order to unravel the thermodynamic and kinetic factors that empower this methodology to be singularly sensitive for the pregnancy biomarker human chorionic gonadotropin (hCG). It is demonstrated that quantitative analysis of hCG detection in artificial urine does not suffer interference. Chapter 5 adapts this approach to survey other biomarkers including β-hCG and brain natriuretic peptide. Combinatorial immunoassays are also investigated through the use of two types of antibodies, each tagged with a different redox label. Chapter 6 exploits the electroactive spin-trapping molecule TEMPO for the detection of biomolecules that have been damaged through oxidative stress. Last, Chapter 7 presents an overall conclusion to the work presented in this thesis.

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Tittikpina, Nassifatou Koko. "Bio-analytical study of plants used in traditional medicine in Togo." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0169/document.

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L'étude des plantes utilisées en médecine traditionnelle au Togo est compliquée à cause de l’absence de matériel de pointe. L'identification assistée par ordinateur de produits basés sur des utilisations en médecine traditionnelle (CAPITURE) a été évaluée dans le cadre d'une enquête ethnobotanique sur le traitement traditionnel des maladies fongiques dans la Préfecture de Tchamba (Togo). Cette méthode a prédit et identifié les plantes les plus biologiquement actives parmi les 43 espèces recensées au cours de l’enquête : Pterocarpus erinaceus prédit être plus actif contre les champignons, et Daniellia oliveri contre les bactéries. Les plantes ont ensuite été testées contre les champignons, les bactéries et les cellules cancéreuses. Comme prédit par CAPITURE, P. erinaceus était plus actif contre les champignons et D. oliveri contre les bactéries. Fait intéressant, les deux plantes ont présenté une activité sur les cellules cancéreuses sans être toxique pour les cellules humaines normales. Dans une troisième étape, en utilisant la chimie analytique, les composés responsables des activités biologiques ont été identifiés. La plupart de ces composés n'ont jamais été signalés dans les espèces végétales ou dans la nature, avec une activité biologique dans la gamme micro-molaire. Enfin, en réduisant la poudre des organes végétaux à la taille de nano-particules, une meilleure activité biologique a été observée par rapport à celle de l'extrait organique. En conclusion, cette recherche a mené à la découverte de nouvelles molécules avec une activité biologique intéressante, molécules qui nécessiteront une étude approfondie et détaillée
The investigation of plants used for traditional medicine in Togo is complicated as modern techniques are not available. Computer-aided product identification from traditional usage records (CAPITURE) was evaluated in the context of an ethnobotanical survey on the traditional treatment of fungal diseases in Tchamba District (Togo). This method predicted and identified the most biologically active plants out of the 43 species survey-recorded: Pterocarpus erinaceus predicted to be more active against fungi and Daniellia oliveri against bacteria. The plants were then tested against fungi, bacteria and cancer cells. As predicted with CAPITURE, P. erinaceus was more active against fungi and D. oliveri against bacteria. Interestingly, both plants presented activity on cancer cells without being toxic to normal human cells. In a third step, using analytical chemistry, the compounds responsible for the biological activities were identified. Most of those compounds have never been reported in the plant species or in nature at all, with biological activity in the micromolar range. Finally, pharmaceutical technology was used: by nanosizing the powder of the plant organs, a better biological activity was observed in comparison to that of the organic extract. In conclusion, this research led to the discovery of new molecules with an interesting biological activity that will need further and more detailed investigation

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Maset, Fabio. "Protein Chemistry and Molecular Medicine." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3422744.

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Proteomics involves the systematic study of proteins in order to provide a comprehensive view of the structure, function and regulation of biological systems. Advances in instrumentation and methodologies have fueled an expansion of the scope of biological studies from simple biochemical analysis of single proteins to measurements of complex protein mixtures. Proteomics is rapidly becoming an essential component of biological research. Coupled with advances in bioinformatics, this approach to comprehensively describing biological systems will undoubtedly have a major impact on our understanding of the phenotypes of both normal and diseased cells. Initially, proteomics was focused on the generation of protein maps using two-dimensional polyacrylamide gel electrophoresis. Protein expression, or the quantitative measurement of the global levels of proteins, may still be done with two-dimensional gels, however, mass spectrometry has been incorporated to increase sensitivity, specificity and to provide results in a high-throughput format. Mass spectrometry applied to proteins offers many advantages: in addition to calculating the molecular weight with high accuracy, this technique allows to analyze and characterize the amino acid sequence. It can also be used in the study of post-translational modifications and to monitor the formation of complexes in solution. Finally it can be applied with different purposes such as the conformational analysis, analysis of the kinetics of refolding and studies on the catalytic activities of proteins. During my Ph.D. course my efforts have been mainly devoted on the use of this technique in combination with methods of protein chemistry such as the one- and two-dimensional electrophoresis, differents liquid chromatographies, solid phase peptide synthesis and use of proteolytic enzymes. Herein reported in my Ph.D. Thesis, the different treated subjects are divided into independent chapters each containing a single case study. Briefly in chapter 2 it has been proposed the study on protease nexin-1 (PN-1), the main inhibitor of thrombin in the brain, aimed at clarifying the role of the carbohydrate portion on the conformation, stability and function, through studies on recombinant protein produced in E.coli. In chapter 3 it has been showed the work on purification and chemical characterization, including de novo identification of amino acid sequence, of a similar inhibitor of phospholipase A2 extracted from the Python sebae serum, which demonstrated an effect cytotoxic pro-apoptotic and that could be exploited for the development of new anticancer strategies. In chapter 4 it has been reported the molecular dynamics that lead to the development of primary hyperoxaluria type I by studying the G41R mutant enzyme alanine: glyoxylate aminotransferase (AGT). In particular, were investigated the mechanisms leading to G41R be more susceptible to degradation and aggregation than wild type protein. Finally, chapter 5 deals with the effect of oxidative stress on the metabolism of von Willebrand Factor (VWF). The von Willebrand Factor is a very complex plasma glycoprotein whose dimensions help to regulate the hemostatic balance. Specifically, in the study was observed as the oxidation of a methionine residue located in the A2 domain of glycoprotein prevents proteolytic cleavage by ADAMTS-13, while not going to influence or, in some cases, promote proteolysis of VWF by proteases released from polymorphonuclear leukocytes in inflammatory conditions.
La proteomica riguarda lo studio sistematico delle proteine al fine di fornire una visione completa della funzione, della struttura e della regolazione dei sistemi biologici. I progressi avvenuti negli ultimi decenni, sia per quanto riguarda la strumentazione sia le metodologie utilizzate, hanno permesso di ampliare il campo di studi biologici passando dall’analisi di proteine purificate all’analisi di miscele complesse. La proteomica sta rapidamente diventando una componente essenziale della ricerca biologica ed associato ai progressi della bioinformatica, questo approccio alla descrizione dei sistemi biologici avrà indubbiamente un impatto notevole sulla nostra comprensione dei fenotipi sia delle cellule normali e malate. Inizialmente la proteomica era focalizzata principalmente sulla generazione di mappe proteiche bidimensionali utilizzando elettroforesi su gel di poliacrilammide. La verifica dell’espressione o la misurazione quantitativa dei livelli globali di proteine può ancora essere fatta sulla base dei gel bidimensionali, tuttavia oramai questi compiti sono affidati alla spettrometria di massa la quale può contare su di un’elevata sensibilità e specificità. La spettrometria di massa applicata alle proteine offre molti vantaggi: oltre a calcolare il peso molecolare con elevata precisione, questa tecnica permette di analizzare e caratterizzare la sequenza aminoacidica. Può anche essere utilizzata nello studio delle modificazioni post-traduzionali e per monitorare la formazione di complessi in soluzione. Infine può essere applicata con differenti scopi, quali l'analisi conformazionale, l'analisi della cinetica di ripiegamento e di studi sulle attività catalitiche delle proteine. Durante il dottorato di ricerca la mia attenzione è stata focalizzata soprattutto sull’utilizzo di tale tecnica abbinata a metodologie di chimica delle proteine quali ad esempio l’elettroforesi mono e bidimensionali, differenti cromatografie in fase liquida, la sintesi peptidica in fase solida e l’utilizzo di proteasi enzimatiche. In particolare in questa Tesi di Dottorato gli argomenti di studio sono stati trattati singolarmente, distinguendo i principali progetti in cui sono stato coinvolto in capitoli indipendenti. Brevemente, nel capitolo 2 è proposto lo studio di protease nexin-1 (PN-1), il principale inibitore della trombina a livello cerebrale, volto a chiarire la funzione della porzione glucidica sulla conformazione, stabilità e funzione della proteina mediante lo studio della proteina ricombinante prodotta in E. coli. Nel capitolo 3 è riportato il lavoro concernente la purificazione e la caratterizzazione chimica, in particolare dell’identificazione de novo della sequenza amminoacidica, di un analogo dell’inibitore della fosfolipasi A2 estratto dal siero di Python sebae, il quale ha dimostrato di possedere un effetto citotossico pro-apoptotico e che potrebbe essere sfruttato per lo sviluppo di nuove strategie antitumorali. Nel capitolo 4 l’attenzione è stata concentrata a chiarire le dinamiche molecolari che portano allo sviluppo di iperossaluria primaria di tipo I mediante lo studio del mutante G41R dell’enzima alanina:gliossilato amminotransferasi (AGT) analizzando in particolar modo i meccanismi che portano G41R ad essere maggiormente soggetto a degradazione e aggregazione rispetto alla proteina WT. Infine, il capitolo 5 tratta dell’effetto dello stress ossidativo sul metabolismo del fattore di von Willebrand (VWF). Il fattore di von Willebrand è una glicoproteina plasmatica estremamente complessa le cui dimensioni contribuiscono a regolare l’equilibrio emostatico. Nello specifico, è stato osservato come l’ossidazione di un residuo di metionina situato nel dominio A2 della glicoproteina impedisca il taglio proteolitico da parte di ADAMTS-13, mentre non vada ad influenzare o in alcuni casi addirittura favorisca la proteolisi di VWF da parte di proteasi leucocitarie liberate dai polimorfonucleati in seguito a stati infiammatori.

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Carelli, S. "DEVELOPING A REGENERATIVE MEDICINE APPROACH FOR THE TREATMENT OF PARKINSON'S DISEASE." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/230550.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease, after Alzheimer’s disease, and the most common movement disorder. Drug treatment and deep brain stimulation can ameliorate symptoms, but the progressive degeneration of dopaminergic neurons in the substantia nigra eventually leads to severe motor dysfunction. While some effective treatments for patients with PD exist, these treatment strategies are mainly symptomatic and aimed at increasing dopamine levels in the degenerating nigrostriatal system. Existing drugs are limited in their relief and decrease in effectiveness as PD progresses.The transplantation of stem cells has emerged as a promising approach to replace lost neurons in order to restore dopamine levels in the striatum and reactivate functional circuits. Post mortem neural precursor cells (PM-NPCs) are a subclass of sub ventricular zone (SVZ)-derived neural progenitors, capable of surviving many hours (16 hours) after donor death. The in vitro differentiation yields more neurons (about 30-40%) compared to regular NPCs (Marfia et al., 2011). Recently from the SVZ of a transgenic mouse strain expressing green fluorescent protein (GFP) under the promoter C of the ubiquitin gene [(C57BL/6-Tg(UBC-GFP)30Scha/J)] we isolated GFP PM-NPCs, from mice at 6 hours after the donor death. These cells were characterized and their potential of in terms of replacement therapy was investigated in a mouse model of Parkinson disease. The degeneration of dopaminergic neurons was obtained through the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) at the dosage of 36 mg/kg intraperiteoneally (i.p.). After 1 week the lesion was stabilized by a second administration (i.p.) of the neurotoxin at the dosage of 20 mg/kg. 1x 105 of PM-PCs-GFP were injected unilaterally into the striatum of C57/BL mice by using specific stereotaxic coordinates 3 days after the second MPTP administration. The effects of transplanted cells were determined by means of performance tests aimed at detecting behavioral improvements. Moreover, the neurochemical changes were also studied by high performance liquid chromatography (HPLC). In order to study the in vivo fate of grafted GFP PM-NPCs animals were perfused 2 weeks after transplantation and immunohistochemistry studies were performed. Our results show that animals grafted with GFP PM-NPCs determined a remarkable improvement of behavioral parameters measured by means of both horizontal and vertical grid tests (forepaw fault and time required to grab on the grids while turning and climbing down) since the third day after transplantation. These improvements were very significant and the average values were close to control animals. This was maintained during all the two weeks of experimental observation. By means of immunofluorescence staining we observed that the majority of transplanted GFP-PM-NPCs were vital and able to migrate ventrally and caudally from the injection site lengths as far as 1000 microns into the striatum, and could reach the ipsilateral and contralateral substantia nigra pars compacta. Moreover, morphological analyses revealed that transplanted cells in the striatum are able to differentiate into tyrosine hydroxylase (40%), cholinergic (40%), and gabaergic neurons (25%). This study provides new evidences that PM-NPCs will be useful for developing cellular PD therapies. Future studies should further explore the clinical potential role of the investigated post mortem neural precursors cells in order to provide new perspectives for PD treatment.

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Hernandez, Gomez Yuriko Suemi. "Nanocomposite scaffolds and biomimetic peptides in neural regenerative medicine." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426354.

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The incapacity of injured adult central nervous system to restore damaged neuronal circuitry and the large peripheral nervous system nerve defect inability to be naturally regenerated are a critical medical and social issue. An emerging approach in neuronal regenerative medicine is the use of native extracellular stimuli at nano-scale level influencing cell growth, differentiation and regeneration. Our biomimetic nanosystems mimic as much as possible the nanotopographic, conductive features and guidance cues of the neuronal extracellular environment. They are made of a freestanding and biocompatible nanocomposite scaffold, combining conductive, mechanical and topographical feature of carbon-based nanomaterials with the biocompatible properties of the poly-L-lactic acid (PLLA) matrix. Moreover, biomimetic peptides have been developed deriving them from neuronal proteins involved in the control of neurite outgrowth and axon pathfinding. In recent work from our team, the combination of the nanocomposite scaffold and the peptides proved to enhance neuronal differentiation of a human neuroblastoma cell line and to promote per se neural differentiation of human multipotent stem cells, even in the absence of exogenously added neurotrophins. In my PhD project I further developed such biomimetic nanosystems. About the scaffold, we checked the biocompatibility and effect on neuronal differentiation of varying types and concentration of nanofiller. We increased from 0.25 to 5% CNTs dispersed in the PLLA-matrix to improve electrical conductivity and nanoroughness of our nanocomposite scaffold. The enhanced CNTs concentration doesn’t affect cell proliferation, viability and adhesion while promoting neurite elongation. Moreover, we tested the same range of carbon nanohorns (CNHs) and reduced graphene oxide (RGO) dispersed in the PLLA matrix and proved they are as biocompatible as CNTs. Interestingly, 5%RGO has an inductive effect on neuronal differentiation. In last months, 3D printing has been used for patterned scaffold that allow to control the cell growth direction. About biomimetic peptides, we focused on the characterization of novel peptides sharing a conserved motif to better reproduce neuronal biochemical cues. These peptides are derived from the Ig-like domain of a number of proteins playing important roles in neuronal differentiation and axon elongation: CHL1, Neurofascin, NrCAM, DCC, ROBO2 and 3, Contactin 1, 2 and 5. All such peptides were able to promote neuritogenesis and neuronal differentiation of SH-SY5Y cells, with efficacy similar to previously tested peptides. In order to shed light on the mechanism by which our peptides act, we studied L1-A peptide in comparison to L1CAM extracellular domain it is derived from. As negative controls we used a scrambled and mutant version of the L1-A peptide. In silico simulations and in vitro evidence suggest an agonist-antagonist mechanism for our peptides: L1-A peptide binds L1CAM and exerts the same neuritogenic effect of the protein acting as L1CAM’s agonist; scrambled and mutant peptides bind the protein and inhibit the L1CAM homophilic binding, but they are not able to activate the signalling intracellular pathway leading to neuronal differentiation, acting as antagonists of L1CAM. In conclusion, our new nanocomposite scaffold and biomimetic peptides are potential tools for neuronal regenerative medicine, even if further investigations are needed to check their effect in combination.
The incapacity of injured adult central nervous system to restore damaged neuronal circuitry and the large peripheral nervous system nerve defect inability to be naturally regenerated are a critical medical and social issue. An emerging approach in neuronal regenerative medicine is the use of native extracellular stimuli at nano-scale level influencing cell growth, differentiation and regeneration. Our biomimetic nanosystems mimic as much as possible the nanotopographic, conductive features and guidance cues of the neuronal extracellular environment. They are made of a freestanding and biocompatible nanocomposite scaffold, combining conductive, mechanical and topographical feature of carbon-based nanomaterials with the biocompatible properties of the poly-L-lactic acid (PLLA) matrix. Moreover, biomimetic peptides have been developed deriving them from neuronal proteins involved in the control of neurite outgrowth and axon pathfinding. In recent work from our team, the combination of the nanocomposite scaffold and the peptides proved to enhance neuronal differentiation of a human neuroblastoma cell line and to promote per se neural differentiation of human multipotent stem cells, even in the absence of exogenously added neurotrophins. In my PhD project I further developed such biomimetic nanosystems. About the scaffold, we checked the biocompatibility and effect on neuronal differentiation of varying types and concentration of nanofiller. We increased from 0.25 to 5% CNTs dispersed in the PLLA-matrix to improve electrical conductivity and nanoroughness of our nanocomposite scaffold. The enhanced CNTs concentration doesn’t affect cell proliferation, viability and adhesion while promoting neurite elongation. Moreover, we tested the same range of carbon nanohorns (CNHs) and reduced graphene oxide (RGO) dispersed in the PLLA matrix and proved they are as biocompatible as CNTs. Interestingly, 5%RGO has an inductive effect on neuronal differentiation. In last months, 3D printing has been used for patterned scaffold that allow to control the cell growth direction. About biomimetic peptides, we focused on the characterization of novel peptides sharing a conserved motif to better reproduce neuronal biochemical cues. These peptides are derived from the Ig-like domain of a number of proteins playing important roles in neuronal differentiation and axon elongation: CHL1, Neurofascin, NrCAM, DCC, ROBO2 and 3, Contactin 1, 2 and 5. All such peptides were able to promote neuritogenesis and neuronal differentiation of SH-SY5Y cells, with efficacy similar to previously tested peptides. In order to shed light on the mechanism by which our peptides act, we studied L1-A peptide in comparison to L1CAM extracellular domain it is derived from. As negative controls we used a scrambled and mutant version of the L1-A peptide. In silico simulations and in vitro evidence suggest an agonist-antagonist mechanism for our peptides: L1-A peptide binds L1CAM and exerts the same neuritogenic effect of the protein acting as L1CAM’s agonist; scrambled and mutant peptides bind the protein and inhibit the L1CAM homophilic binding, but they are not able to activate the signalling intracellular pathway leading to neuronal differentiation, acting as antagonists of L1CAM. In conclusion, our new nanocomposite scaffold and biomimetic peptides are potential tools for neuronal regenerative medicine, even if further investigations are needed to check their effect in combination.

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Agyapong-Badu, S. "Non-invasive bio-markers of motor performance with ageing." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/372918/.

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Objective tests of motor function suitable for older people in epidemiological studies and community settings are lacking. The current study aimed to establish non-invasive biomarkers using conventional and novel tests that do not rely entirely on volition, and identify suitable analysis techniques for complex data. It was hypothesised that novel technologies would improve the discriminant validity of motor function testing. In 138 self-reported healthy males and females (65 young, mean age±SD = 25.7±4.8 years; 73 older, 74.9±5.9 years), nine tests (25 parameters) included: hand grip and quadriceps strength; respiratory muscle strength (peak flow); thigh composition (ultrasound imaging); muscle mechanical properties (Myoton technology); upper limb kinematics (Motor Task Manager); timed up and go; stair climbing; balance. Three questionnaires and one mobility assessment were administered including the health related quality of life (SF36). Four experiments tested hypotheses regarding the influence of recording conditions on mechanical properties to validate the novel MyotonPRO device. Reliability of all tests was confirmed and, as expected, data indicated reduced function with ageing (all p<0.05), with the majority showing gender differences. Some mechanical properties were significantly influenced by testing site, muscle length, contractile status and prior activity. Seven of the 25 parameters (5novel) had high discriminant ability for classifying healthy adults into age/gender groups analysed by linear discriminant function using a stepwise approach. Novel technologies, notably mechanical properties of muscle and thigh composition (relative contribution of muscle and subcutaneous fat on ultrasound scans), improved classification accuracy (from 75% to 89%) when combined with conventional tests, supporting the hypothesis and providing potential screening tools independent of participant effort. High discriminant ability (73 to 80%) was also found for classification based on functional measures. This research has advanced the approach to functional assessment and analysis by producing a comprehensive battery of non-invasive biomarkers with high discriminant ability for indicating musculoskeletal health, providing reference data for comparison with clinical populations. The most sensitive novel biomarkers did not require volition, highlighting potential powerful tests for vulnerable older people with pain or cognitive impairment.

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Bevilacqua, Elisa. "Non-invasive prenatal testing: a new era in fetal medicine." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/304668.

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Les anomalies chromosomiques sont une cause majeure de morbidité et de mortalité périnatales. Le dépistage de ces affections a toujours été crucial pour une prise en charge optimale des femmes enceintes.Initialement, le dépistage de trisomie 21 était uniquement basé selon le risque lié à l’âge maternel. L’ajout de différents marqueurs biochimiques sériques constituant successivement les double, triple et quadruple tests a pu améliorer le taux de détection. Néanmoins, c’est en 1997 qu’apparaît un point tournant de l’histoire de dépistage des trisomies :l’introduction de la mesure de la clarté nucale à l’échographie du premier trimestre.Depuis 2011, de nouvelles recherches se sont concentrées sur le dépistage prénatal non invasif (DPNI) utilisant l'ADN fœtal libre circulant dans le sang maternel. Cette technique a suggéré directement une supériorité marquée pour la détection de la trisomie 21 comparée à toutes les autres méthodes de dépistage connues. Rapidement, ce test a été introduit en pratique clinique dans le monde entier sans une évaluation préalable et approfondie, que ce soit au niveau scientifique, technique ou éthique.Les objectifs de cette thèse étaient de fournir des réponses aux diverses questions persistantes concernant l’utilisation clinique des tests de dépistages basés sur ADN fœtal libre dans la circulation maternelle.À notre connaissance, nous sommes la première équipe à essayer d'évaluer le taux d'échec et la performance du DPNI effectué par différents laboratoires utilisant différentes méthodes analytiques. Nous avons démontré que les approches « DANSR » (approche ciblée sur les chromosomes d’intérêt) et « GW-MPS » (approche globale sur les séquences géniques reparties sur la totalité du génome par un séquençage à haut débit) offraient toutes les deux un taux échec bas avec une bonne performance dans la détection des trisomies 21, 13 et 18. Cependant, le niveau de fraction fœtale semble varier d'un laboratoire à l'autre et n’est, par conséquent, pas comparable. Nous avons également observé que le taux d'échec des laboratoires avec un test « home-brew » était 4 fois supérieur à celui des tests commerciaux développés par les laboratoires en interne. De plus, aucune pertinence clinique de la divulgation des aneuploïdies autres que les 3 trisomies communes décelées par les DPNI « GW-MPS » n’a pu être démontrée.Ensuite, nous nous sommes intéressés au groupe particulier des grossesses gémellaires. Dans ce groupe, le DPNI était faisable mais il était associé à un taux d'échec supérieur aux grossesses uniques, tout en fournissant un taux de détection moindre des trisomies communes. Un poids maternel élevé et la conception par fécondation in vitro étaient des facteurs indépendants associés à l’échec du test. De plus, il faut souligner l’importance de développer des normes de contrôle de qualité pour les analyses faites sur l’ADN fœtal libre. Nous avons aussi étudié les modifications de l’ADN fœtal libre après une mort fœtale en raison d’une aneuploïdie chez l’un des deux fœtus lors d’une grossesse gémellaire. Après le décès du fœtus atteint, la fraction fœtale de l’ADN libre circulant dans le sang maternel a montré une évolution imprévisible, pouvant augmenter, diminuer ou rester stable dans le temps. Par conséquent, ces résultats déconseillent l’utilisation du DPNI en cas de décès d’un des deux fœtus, même après un intervalle de temps de plusieurs semaines.Notre attention s’est ensuite portée vers la performance du DPNI pour le dépistage des anomalies autres que les 3 trisomies communes. Nous avons d’abord étudié la performance du DPNI pour les anomalies des chromosomes sexuels ainsi que les caractéristiques des patientes optant pour ce test. Plus de la moitié des patientes ayant eu un DPNI ont également souhaité le dépistage des anomalies des chromosomes sexuels. Les valeurs prédictives positives suivantes ont été observées :24% pour 45 X et 47 XXX et environ 71% pour 47 XXY et 47 XYY. Ainsi, la recherche d’anomalies des chromosomes sexuels peut causer la détection accidentelle d’anomalies chromosomiques sans conséquence clinique. Par conséquent, un conseil génétique est obligatoire dans toutes ces situations, de même qu’un examen invasif pour un caryotype fœtal de confirmation.Ensuite, nous avons montré que le test à ADN fœtal libre utilisant une technologie ciblée basée sur le microarray permettait d'identifier les grossesses à risque accru de délétions 22q11.2. Cependant, des données fiables sur les performances du DPNI pour le syndrome 22q11.2 sont encore manquantes, et des recherches plus poussées sont nécessaires. Depuis 2015, nous participons à une étude prospective, multicentrique et en aveugle, qui évalue cliniquement un test d’ADN fœtal libre pour la détection de délétions ou de duplications dans la région 22q11. Le recrutement s’est terminé le 1er novembre 2019.Enfin, en décrivant le profil et le choix des patientes belges soumises à un test à ADN fœtal libre, nous avons observé un changement vers une population à faible risque, ce qui peut entrainer une réduction de la valeur prédictive positive du test. Il est donc primordial que cet effet soit connu des professionnels de la santé qui conseillent, prescrivent et interprètent ces tests.En conclusion, notre recherche a démontré la complexité des tests à ADN fœtal libre circulant dans le sang maternel, non seulement du point de vue technique, mais également en termes de conseils aux patients avant et après le test, ce qui requière des connaissances et compétences spécifiques des médecins proposant ces tests.L’ère du test à ADN fœtal libre circulant dans le sang maternel n’en est qu’à ses débuts. Notre travail n’a exploré qu’une petite partie de l’énorme potentiel de ce nouvel outil de dépistage des aneuploïdies.L’intégration responsable des innovations dans la pratique clinique reste, aujourd’hui, l’un des défis majeurs.
Doctorat en Sciences médicales (Médecine)
info:eu-repo/semantics/nonPublished

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Monegro, Dr Francisco. Bio-Magnetic Medicine/Medicina Bio-Magnetica: Poderes y secretos de la energia magnetica. New York: NY Institute for Holistic Life, 1996.

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Bártolo, Paulo, and Bopaya Bidanda, eds. Bio-Materials and Prototyping Applications in Medicine. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-47683-4.

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Bártolo, Paulo Jorge, and Bopaya Bidanda, eds. Bio-Materials and Prototyping Applications in Medicine. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-35876-1.

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Bopaya, Bidanda, and SpringerLink (Online service), eds. Bio-Materials and Prototyping Applications in Medicine. Boston, MA: Springer Science+Business Media, LLC, 2008.

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Boyd, Robert. An introduction to bio cranial therapy. Bangor, Co. Down, England: The International Bio Cranial Academy, 1988.

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Machala, Zdenko, Karol Hensel, and Yuri Akishev, eds. Plasma for Bio-Decontamination, Medicine and Food Security. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2852-3.

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NATO Advanced Research Workshop on Plasma for Bio-Decontamination, Medicine and Food Security (2011 Demänovská dolina, Slovakia). Plasma for bio-decontamination, medicine and food security. Dordrecht: Springer, 2012.

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Lima, Olavo Correia. Panteão médico maranhense. São Luís: CORSUP/EDUFMA, 1993.

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Mishra, K. P. Radiobiology and bio-medical research. New Delhi: Narosa Pub. House, 2004.

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Khu̇rėlbaatar, S. Khovs, bio oron zaĭn ȯvchlȯl, ėmchilgėė. Ulaanbaatar khot: Sėtgėshgu̇ĭ Ėmnėlėg, 2012.

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Kumashiro, Yoshikazu, Masayuki Yamato, and Teruo Okano. "Nanotechnology for Regenerative Medicine." In Bio-Nanotechnology, 124–40. Oxford, UK: Blackwell Publishing Ltd., 2013. http://dx.doi.org/10.1002/9781118451915.ch7.

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Jones, Julian R. "Sol-Gel Derived Glasses for Medicine." In Bio-Glasses, 29–44. Chichester, UK: John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781118346457.ch3.

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Meetoo, Danny D. "Nanomedicine: The Revolution of the Big Future with Tiny Medicine." In Bio-Nanotechnology, 163–78. Oxford, UK: Blackwell Publishing Ltd., 2013. http://dx.doi.org/10.1002/9781118451915.ch9.

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Schwendener, Reto A. "Liposomes in Biology and Medicine." In Bio-Applications of Nanoparticles, 117–28. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-76713-0_9.

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Aziz, Rabia. "Applications of Nanomaterials in Tissue Engineering and Regenerative Medicine." In Bio-manufactured Nanomaterials, 187–202. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67223-2_9.

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Whitney, Kaitlyn E., Ioanna Bolia, Jorge Chahla, Hajime Utsunomiya, Thos A. Evans, Matthew Provencher, Peter J. Millett, Robert F. LaPrade, Marc J. Philippon, and Johnny Huard. "Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches." In Bio-orthopaedics, 71–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54181-4_6.

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Hu, Yingjie, Nikola Kasabov, and Wen Liang. "Personalized Information Modeling for Personalized Medicine." In Springer Handbook of Bio-/Neuroinformatics, 533–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-30574-0_33.

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Gupta, Meenu, and Kumari Seema. "Living Nano-factories: An Eco-friendly Approach Towards Medicine and Environment." In Bio-manufactured Nanomaterials, 95–124. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67223-2_6.

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Baker, James R. "Nanotechnology for Biology and Medicine." In Managing nano-bio-info-cogno innovations, 119–32. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-4107-1_9.

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Tsoukalas, Dimitris, Evangelia Sarandi, and Maria Thanasoula. "Non-communicable Diseases in the Era of Precision Medicine: An Overview of the Causing Factors and Prospects." In Bio#Futures, 275–99. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64969-2_13.

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Тези доповідей конференцій з теми "Bio medicine"

Rosaline, S. Imaculate, and S. Raghavan. "Survey on metamaterials in bio-medicine." In 2013 IEEE International Conference on Computational Intelligence and Computing Research (ICCIC). IEEE, 2013. http://dx.doi.org/10.1109/iccic.2013.6724184.

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Czajkowski, Amber. "Better Medicine Through Proper Lighting." In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/boda.2011.bwa2.

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Xie, Sunney. "Label-Free Vibrational Imaging for Medicine." In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/boda.2013.jm1a.3.

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Jakobsson, Eric, May D. Wang, and Linda Molnar. "Bio-Nano-Info Integration for Personalized Medicine." In 2007 IEEE 7th International Symposium on BioInformatics and BioEngineering. IEEE, 2007. http://dx.doi.org/10.1109/bibe.2007.4375770.

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Li, Xiaoxia, Shifu Fan, and Youquan Zhao. "Bio-tissue temperature measuring for laser medicine." In SPIE Proceedings, edited by Ivan A. Shcherbakov, Kexin Xu, Qingyue Wang, Alexander V. Priezzhev, and Vladimir I. Pustovoy. SPIE, 2006. http://dx.doi.org/10.1117/12.693606.

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Jeutter, Dean, John Hines, and Mark Geisler. "Microcontroller based PCM bio-transceiver system for the ABTS (Advanced Bio Telemetry System)." In Life Sciences and Space Medicine Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1995. http://dx.doi.org/10.2514/6.1995-1057.

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Grundfest, Warren S. "APPLICATIONS OF PULSED ULTRAVIOLET LASERS IN MEDICINE." In Biomedical Topical Meeting. Washington, D.C.: OSA, 1999. http://dx.doi.org/10.1364/bio.1999.cwd1.

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Cherry, Simon. "Molecular Imaging at the Interface of Optical Imaging and Nuclear Medicine." In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/boda.2013.jm3a.2.

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Gray, Bonnie L. "Bio-microinstrumentation technology: discrete components to modular systems." In SPIE Nanosystems in Engineering + Medicine, edited by Sang H. Choi, Jin-Ho Choy, Uhn Lee, and Vijay K. Varadan. SPIE, 2012. http://dx.doi.org/10.1117/12.979685.

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Takafuji, Ernest T. ""Bio-Defense Technologies"." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.259777.

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Swiston, Albert J., and Milan Raj. FY12 Line-Supported Bio-Medical Initiative Program: Advanced Photoplethysmography (PPG) Sensors for Operational and Casualty Care Medicine. Fort Belvoir, VA: Defense Technical Information Center, February 2013. http://dx.doi.org/10.21236/ada580581.

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Crespo, Anna Risi Vianna, Monika Huppi, Hector Conroy, Oliver Azuara Herrera, Roni Szwedzki, Eva Bolza-Schunemann, Danya Churanek, and Kris Hallberg. Medición del desempeño de los proyectos en el BID: Evolución reciente de los sistemas PCR y XPSR. Banco Interamericano de Desarrollo (BID), June 2015. http://dx.doi.org/10.18235/0000022.

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Bastante, Marcelo. Estudio Fintech 2020: Ecosistema Argentino. Inter-American Development Bank, July 2020. http://dx.doi.org/10.18235/0002892.

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El estudio representa una actualización del primer informe sobre el ecosistema Fintech en Argentina llevado a cabo en el año 2018. Describe la evolución y los avances ocurridos con respecto a la medición y el análisis realizado anteriormente, además de examinar nuevas dimensiones relevantes en el sector. La primera sección brinda una descripción general del ecosistema actual, en donde se refleja su crecimiento desde el año 2018, el panorama de la industria, su distribución y alcance en el país, y sus principales indicadores (financiamiento, clientes, usuarios y empresas). El estudio cuenta con la particularidad de haberse realizado en pleno proceso de la crisis sanitaria generada por la pandemia COVID-19, por lo que parte del estudio aborda las áreas de impacto de la crisis en las Fintech, según la visión de los integrantes del ecosistema. La segunda sección aborda un análisis por vertical Fintech, es decir por nueve segmentos de actividad dentro del ecosistema: Préstamos, Pagos digitales, Blockchain & Criptoactivos, Insurtech, Inversiones, Servicios B2B, Financiamiento colectivo, Seguridad informática y Proveedor tecnológico. La tercera sección se centra en el estudio de cuatro temas transversales que atañen a todos los segmentos o sectores. Estos temas transversales se denominan horizontales: Inclusión y Educación Financiera, Género, Marco Regulatorio y Ambiente. Si bien estos horizontales se encuentran interrelacionados, se analizan individualmente. En la última sección se presentan tres casos de estudio - Ualá, Mercado Fondos y Afluenta - centrados en el rol de las Fintech en la promoción de una inclusión financiera. El estudio cuenta con la colaboración de la Cámara Argentina de Fintech, el BID Lab, Afluenta y la participación de los protagonistas de la industria que fueron encuestados para el desarrollo del informe, y entrevistados para los casos de estudio.

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Mineral resources of the Medicine Lodge, Alkali Creek, and Trapper Creek Wilderness Study Areas, Big Horn County, Wyoming. US Geological Survey, 1989. http://dx.doi.org/10.3133/b1756a.

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