Готові списки джерел за темами / Base editors

Добірка наукової літератури з теми "Base editors"

Автор: Grafiati
Опубліковано: 14 березня 2023

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Статті в журналах з теми "Base editors"

1

Bellingrath, Julia-Sophia, Michelle E. McClements, Maria Kaukonen, Manuel Dominik Fischer, and Robert E. MacLaren. "In Silico Analysis of Pathogenic CRB1 Single Nucleotide Variants and Their Amenability to Base Editing as a Potential Lead for Therapeutic Intervention." Genes 12, no. 12 (November 27, 2021): 1908. http://dx.doi.org/10.3390/genes12121908.

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Анотація:
Mutations in the Crumbs homolog 1 (CRB1) gene cause both autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). Since three separate CRB1 isoforms are expressed at meaningful levels in the human retina, base editing shows promise as a therapeutic approach. This retrospective analysis aims to summarise the reported pathogenic CRB1 variants and investigate their amenability to treatment with currently available DNA base editors. Pathogenic single nucleotide variants (SNVs) were extracted from the Leiden open-source variation database (LOVD) and ClinVar database and coded by mutational consequence. They were then analyzed for their amenability to currently available DNA base editors and available PAM sites from a selection of different Cas proteins. Of a total of 1115 unique CRB1 variants, 69% were classified as pathogenic SNVs. Of these, 62% were amenable to currently available DNA BEs. Adenine base editors (ABEs) alone have the potential of targeting 34% of pathogenic SNVs; 19% were amenable to a CBE while GBEs could target an additional 9%. Of the pathogenic SNVs targetable with a DNA BE, 87% had a PAM site for a Cas protein. Of the 33 most frequently reported pathogenic SNVs, 70% were targetable with a base editor. The most common pathogenic variant was c.2843G>A, p.Cys948Arg, which is targetable with an ABE. Since 62% of pathogenic CRB1 SNVs are amenable to correction with a base editor and 87% of these mutations had a suitable PAM site, gene editing represents a promising therapeutic avenue for CRB1-associated retinal degenerations.
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2

Evanoff, Mallory, and Alexis C. Komor. "Base editors: modular tools for the introduction of point mutations in living cells." Emerging Topics in Life Sciences 3, no. 5 (September 10, 2019): 483–91. http://dx.doi.org/10.1042/etls20190088.

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Base editors are a new family of programmable genome editing tools that fuse ssDNA (single-stranded DNA) modifying enzymes to catalytically inactive CRISPR-associated (Cas) endonucleases to induce highly efficient single base changes. With dozens of base editors now reported, it is apparent that these tools are highly modular; many combinations of ssDNA modifying enzymes and Cas proteins have resulted in a variety of base editors, each with its own unique properties and potential uses. In this perspective, we describe currently available base editors, highlighting their modular nature and describing the various options available for each component. Furthermore, we briefly discuss applications in synthetic biology and genome engineering where base editors have presented unique advantages over alternative techniques.
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3

Monsur, Mahmuda Binte, Gaoneng Shao, Yusong Lv, Shakeel Ahmad, Xiangjin Wei, Peisong Hu, and Shaoqing Tang. "Base Editing: The Ever Expanding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Tool Kit for Precise Genome Editing in Plants." Genes 11, no. 4 (April 24, 2020): 466. http://dx.doi.org/10.3390/genes11040466.

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Анотація:
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9), a newly developed genome-editing tool, has revolutionized animal and plant genetics by facilitating modification of target genes. This simple, convenient base-editing technology was developed to improve the precision of genome editing. Base editors generate precise point mutations by permanent base conversion at a specific point, with very low levels of insertions and deletions. Different plant base editors have been established by fusing various nucleobase deaminases with Cas9, Cas13, or Cas12a (Cpf1), proteins. Adenine base editors can efficiently convert adenine (A) to guanine (G), whereas cytosine base editors can convert cytosine (C) to thymine (T) in the target region. RNA base editors can induce a base substitution of A to inosine (I) or C to uracil (U). In this review, we describe the precision of base editing systems and their revolutionary applications in plant science; we also discuss the limitations and future perspectives of this approach.
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4

Rusk, Nicole. "Better base editors." Nature Methods 15, no. 10 (October 2018): 763. http://dx.doi.org/10.1038/s41592-018-0154-4.

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5

Tang, Lei. "Base editors beware." Nature Methods 17, no. 1 (January 2020): 21. http://dx.doi.org/10.1038/s41592-019-0705-3.

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6

Kantor, Ariel, Michelle McClements, and Robert MacLaren. "CRISPR-Cas9 DNA Base-Editing and Prime-Editing." International Journal of Molecular Sciences 21, no. 17 (August 28, 2020): 6240. http://dx.doi.org/10.3390/ijms21176240.

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Анотація:
Many genetic diseases and undesirable traits are due to base-pair alterations in genomic DNA. Base-editing, the newest evolution of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based technologies, can directly install point-mutations in cellular DNA without inducing a double-strand DNA break (DSB). Two classes of DNA base-editors have been described thus far, cytosine base-editors (CBEs) and adenine base-editors (ABEs). Recently, prime-editing (PE) has further expanded the CRISPR-base-edit toolkit to all twelve possible transition and transversion mutations, as well as small insertion or deletion mutations. Safe and efficient delivery of editing systems to target cells is one of the most paramount and challenging components for the therapeutic success of BEs. Due to its broad tropism, well-studied serotypes, and reduced immunogenicity, adeno-associated vector (AAV) has emerged as the leading platform for viral delivery of genome editing agents, including DNA-base-editors. In this review, we describe the development of various base-editors, assess their technical advantages and limitations, and discuss their therapeutic potential to treat debilitating human diseases.
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7

Buchumenski, Ilana, Shalom Hillel Roth, Eli Kopel, Efrat Katsman, Ariel Feiglin, Erez Y. Levanon, and Eli Eisenberg. "Global quantification exposes abundant low-level off-target activity by base editors." Genome Research 31, no. 12 (October 19, 2021): 2354–61. http://dx.doi.org/10.1101/gr.275770.121.

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Анотація:
Base editors are dedicated engineered deaminases that enable directed conversion of specific bases in the genome or transcriptome in a precise and efficient manner, and hold promise for correcting pathogenic mutations. A major concern limiting application of this powerful approach is the issue of off-target edits. Several recent studies have shown substantial off-target RNA activity induced by base editors and demonstrated that off-target mutations may be suppressed by improved deaminases versions or optimized guide RNAs. Here, we describe a new class of off-target events that are invisible to the established methods for detection of genomic variations and were thus far overlooked. We show that nonspecific, seemingly stochastic, off-target events affect a large number of sites throughout the genome or the transcriptome, and account for the majority of off-target activity. We develop and employ a different, complementary approach that is sensitive to the stochastic off-target activity and use it to quantify the abundant off-target RNA mutations due to current, optimized deaminase editors. We provide a computational tool to quantify global off-target activity, which can be used to optimize future base editors. Engineered base editors enable directed manipulation of the genome or transcriptome at single-base resolution. We believe that implementation of this computational approach would facilitate design of more specific base editors.
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8

Aparicio-Prat, Estel, Dong Yan, Marco Mariotti, Michael Bassik, Gaelen Hess, Jean-Philippe Fortin, Andrea Weston, Hualin S. Xi, and Robert Stanton. "Roadmap for the use of base editors to decipher drug mechanism of action." PLOS ONE 16, no. 9 (September 21, 2021): e0257537. http://dx.doi.org/10.1371/journal.pone.0257537.

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Анотація:
CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key process in drug discovery. Here, we explore the utility of base editors in an early drug discovery context focusing on G-protein coupled receptors. A pooled mutagenesis screening framework was set up based on a modified version of the CRISPR-X base editor system. We determine optimized experimental conditions for mutagenesis where sgRNAs are delivered by cell transfection or viral infection over extended time periods (>14 days), resulting in high mutagenesis produced in a short region located at -4/+8 nucleotides with respect to the sgRNA match. The β2 Adrenergic Receptor (B2AR) was targeted in this way employing a 6xCRE-mCherry reporter system to monitor its response to isoproterenol. The results of our screening indicate that residue 184 of B2AR is crucial for its activation. Based on our experience, we outline the crucial points to consider when designing and performing CRISPR-based pooled mutagenesis screening, including the typical technical hurdles encountered when studying compound pharmacology.
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9

Miquel-Ribé, Marc. "User Engagement on Wikipedia, A Review of Studies of Readers and Editors." Proceedings of the International AAAI Conference on Web and Social Media 9, no. 5 (August 3, 2021): 67–74. http://dx.doi.org/10.1609/icwsm.v9i5.14695.

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Is it an encyclopedia or a social network? Without considering both aspects it would not be possible to understand how a worldwide army of editors created the largest online knowledge repository. Wikipedia has a consistent set of rules and it responds to many of the User Engagement Framework attributes, and this is why it works. In this paper, we identify these confirmed attributes as well as those presenting problems. We explain that although having a strong editor base Wikipedia is finding it challenging to maintain this base or increase its size. In order to understand this, scholars have analyzed Wikipedia using current metrics like user session and activity. We conclude there exist opportunities to analyze engagement in new aspects in order to understand its success, as well as to redesign mechanisms to improve the system and help the transition between reader and editor.
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10

Neff, Ellen P. "Base editors versus PKU." Lab Animal 48, no. 1 (December 12, 2018): 27. http://dx.doi.org/10.1038/s41684-018-0214-5.

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Дисертації з теми "Base editors"

1

Donati, Francesco. "RNA editing deficient mutants of APOBEC1: from genome editing to cancer." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1096842.

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APOBEC-1 is a cytosine-to-uracil deaminase that exerts its primary physiological role in the editing of the Apolipoprotein B mRNA at C6666. Recent studies outlined the ability of APOBEC1 to edit also DNA, thus linking its mutational property to the its overexpression in cancer. Several reports suggest that APOBEC1 can alter the cellular state by targeting RNA molecules. Our hypothesis portrays APOBEC1 as the trigger for a dual path towards cancer through its DNA- and RNA- targeting abilities, and its activity as central to the onset of tumorigenic features. Aim of my PhD project is to understand whether APOBEC1 oncogenic potential is mainly related to its ability to edit RNA or DNA. To this aim, I assessed the tumorigenic potential of a set of APOBEC1 mutants, selected for a dissociation in their RNA and DNA editing ability: they are DNA editing proficient but unable to edit RNA. I characterized these mutants and I tested them in mice to assess their ability to trigger liver tumors. Even if unable to edit RNA, the APOBEC1 mutants are still able to induce tumor formation. This means that RNA editing does not play a central role in the oncogenic potential of APOBEC1. Moreover, considering the recent developments in genome editing, I have exploited these mutants as base editors -fusions of the DNA targeting Cas9 with a DNA deaminase- that allow the correction of single bases: the most common mutator moiety in cytosine-targeting base editors is based on APOBEC1, but overexpression of the APOBEC1-Cas9 chimera results in a substantial amount of RNA and DNA off-target alterations. Once fused with Cas9, our RNA-editing deficient mutants were able to mutate the target DNA. On the other hand, I demonstrated that their off-target activity on RNA is orders of magnitude lower than that of wild type APOBEC1, at the same levels of the negative controls. Exploitation of these mutants could thus provide tools for safer base editing both in vitro and in vivo.
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2

Lembo, Gaia. "Substrate targeting and inhibition of editing deaminases." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1144295.

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Identification of small molecules against APOBEC3B The APOBECs are deaminases that act on DNA and RNA to restrict exogenous nucleic acids. Yet, the signature of their mutagenic activity –especially that of APOBEC3A and APOBEC3B- has been observed in the cancer genomes and their ability to increase the genetic heterogeneity of tumours has been linked to the onset of drug resistance in cancer. As such inhibition of their enzymatic activity represents a potential target for anticancer therapies. During my PhD I worked at the identification of APOBEC3B small-molecule inhibitors. To this aim, I used a computational approach to perform a virtual screening on large library of molecules to block APOBEC3B enzymatic activity. I then tested selected molecules from the virtual screening using biochemical assays to quantify their effect on APOBEC3B activity and their capacity to interfere with APOBEC3B binding to DNA. Through this, I was able to identify two small molecules that reduce the activity of this protein, which could provide basis for the development of the first drug for anti-APOBEC activity. Engineering ADAR2 to act on DNA Genome editing technologies have revolutionized our ability to target and modify the genomes of living cells and organisms. The fusion of AID/APOBECs to genome editing tools such as Cas9 allowed the development the first base editor, molecules that can be targeted to mutate specific cytosines. The pool of available Base Editors is in constant expansion as new molecules are developed to target DNA with more specificity and efficiency. As the only adenine-targeting Base Editor is based on TadA- an RNA deaminase-, I focused on the development of a A•T base editor based on the catalytic domain of ADAR2. Adenosine Deaminases Acting on RNA (ADARs), are editing enzymes that catalyse the C6 deamination of adenosine (A) to produce inosine (I) in double-stranded RNA. As human ADAR2 is able to target DNA/RNA hybrids, I first tried -without success- to use chimeras of n/dCas9 and the deaminase domain of ADAR2 to induce mutations in a fluorescent reporter. I then used a bacterial screen to select for mutants of ADAR2 that act on DNA. I selected a mutant that induces a mutator phenotype in bacteria and DNA damage in mammalian cells. I am currently working to engineer this mutant into a Base Editor suitable for biotechnological applications such as gene therapy, antiviral treatment and cancer therapy.
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3

McCaskill, George Alexander. "Generating programming environments with integrated text and graphics for VLSI design systems." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/6628.

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The constant improvements in device integration, the development of new technologies and the emergence of new design techniques call for flexible, maintainable and robust software tools. The generic nature of compiler-compiler systems, with their semi-formal specifications, can help in the construction of those tools. This thesis describes the Wright editor generator which is used in the synthesis of language-based graphical editors (LBGEs). An LBGE is a programming environment where the programs being manipulated denote pictures. Editing actions can be specified through both textual and graphical interfaces. Editors generated by the Wright system are specified using the formalism of attribute grammars. The major example editor in this thesis, Stick-Wright, is a design entry system for the construction of VLSI circuits. Stick-Wright is a hierarchical symbolic layout editor which exploits a combination of text and graphics in an interactive environment to provide the circuit designer with a tool for experimenting with circuit topologies. A simpler system, Pict-Wright: a picture drawing system, is also used to illustrate the attribute grammar specification process. This thesis aims to demonstrate the efficacy of formal specification in the generation of software-tools. The generated system Stick-Wright shows that a text/graphic programming environment can form the basis of a powerful VLSI design tool, especially with regard to providing the designer with immediate graphical feedback. Further applications of the LBGE generator approach to system design are given for a range of VLSI design activities.
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4

Hedman, Per. "Requirement specification Editor : REQUIREMENTS EDITOR BASED ON CONTRACT THEORY." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177130.

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Vid utveckling av tyngre fordon inför man allt fler avancerade funktione. Mycket av denna funktionalitet handlar om att maskiner automatiskt ska utföra uppgifter för att assistera föraren. Detta leder till att nya risker uppstår. Och till följd av detta har man börjat skapa nya funktionella säkerhetsstandarder. ISO 26262 är en ny funktionell säkerhetsstandard som finns för vanliga personbilar men som ännu inte trätt i kraft för lastbilar. I ISO-26262 standarden ska krav kunna mappas till andra krav samt till systemarkitektur. I nuläget finns det vissa verktyg på marknaden som stödjer användaren när den skriver kravspecifikationer. Men undersökningar av verktyg ledde till att vi kommit fram till att alla hade någon brist. Och ingen hade bra stöd för mappning mellan krav och systemarkitektur. I detta examensarbete har arbetet varit att testa implementera funktionalitet för ett verktyg som assisterar användaren på olika sätt när den skriver kravspecifikationer. Baserat på kontraktteori och konceptet om portar som hjälp för att koppla samman krav med systemarkitektur ska applikationen se till att det finns en formell koppling mellan dessa. För att testa och validera att portar går att använda för att testa intressant funktionalitet har också en applikation utvecklats där mycket funktionalitet implementerats. Resultatet har varit lyckat då vi baserat på kontraktteori lyckats implementera och validera att det är möjligt att använda portar för att skapa koppling mellan krav och systemarkitektur, samt mellan krav och krav. Validering av att det valda lagringsformatet JSON också förser implementeraren med nog starkt stöd för att kunna spara dessa krav så att data i filerna kan brytas ner och lagras i temporära databasen Neo4J och på så sätt skapa ett fungerande kretslopp.
When developing new heavy vehicles today demands for increasingly more advanced features are asked for. A lot of the new functionality is about machines performing tasks automatically to assist the driver when driving. This leads to new risks, and as a result a new functional safety standard has been created. ISO 26262 is a functional safety standard that today exists for ordinary cars, but has not yet became a standard for trucks. According to the ISO 26262-standard requirements can be mapped to other requirements as well as to the system architecture. At present there are several tools on the market that supports the user when writing specifications. However, our research of the tools has led us to conclude that all lacked something. For example neither of the tools had good support for mapping between requirements and system architecture. In this thesis work, functionality for a tool which is supposed to support the user in various ways when writing requirements specifications was to be examined. Based on contract theory and the concept of ports that links requirements together with system architecture, an application can ensure that there is a formal link between the two. To test the suggested functionality a prototype is being developed. The result has been a successful as we based on contract theory could validate that using ports to create links between different requirements as well as between requirements and system architecture works through the implementation of the tool. Validation that the selected storage format JSON also provides the implementer with enough support to save the requirements in a way so that the data files can be decomposed and stored in the Neo4J database.
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5

Li, Rui. "Operation transformation based concurrency control in group editors." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4151.

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Collaborative editing systems (or group editors) allow a geographically dispersed group of human users to view and modify shared multimedia documents, such as research papers, design diagrams, web pages and source code together over a computer network. In addition to being useful tools, group editors are a classic research vehicle and model of interactive groupware applications, based on which a variety of social and technical issues have been investigated. Consistency maintenance as a fundamental problem in group editors has attracted constant research attention. Operational transformation (OT) is an optimistic consistency maintenance method that supports unconstrained collaboration among human users. Although significant progress has been achieved over the past decade, there is still a large space for improvement on the theoretical part of OT. In this dissertation, we are concerned with three problems: (1) How to evaluate the correctness of OT-based consistency maintenance protocols; (2) How to design and prove correct OT-based protocols; (3) What are the consistency correctness conditions for group editing systems in general. This dissertation addresses the above three problems and makes the following contributions: (1) propose a total order based framework including a new consistency model and the associated design methodology. This framework reduces the complexities of the OT design; (2) improve the total order based framework by introducing a natural order based framework. In contrast, this framework removes the requirement of defining a total order that is not necessary to the OT design; (3) establish a generic consistency model and propose the first set of practical design guidelines in OT based on this model.
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6

Choudhury, Surajit. "A fragment based program editor /." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65502.

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7

Han, Kwon Soo. "Surveygen: A web-based survey editor." CSUSB ScholarWorks, 1998. https://scholarworks.lib.csusb.edu/etd-project/1786.

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8

Amai, Takamitsu. "Development of genome editing technology of mitochondrial DNA in Saccharomyces cerevisiae." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263707.

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9

Jeet, E. J. "A relationship-based interactive graphical diagram editor." Thesis, University of Kent, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378580.

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10

Kadlčík, Stanislav. "Webový editor audia." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-413324.

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Анотація:
The Web Based Audio Editor thesis deals with the requirements specification, selection of technologies and with the implementation itself. The thesis uses modern approaches of HTML5 standards and is divided into the client and the server parts. Both the web application and the server are implemented in JavaScript. The Web based audio editor allows basic editing features like cut, shifting, deleting. All this in multiple audio tracks. The application runs in recent versions of the most widely used web browsers.
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Книги з теми "Base editors"

1

Bae, Sangsu, and Beomjong Song, eds. Base Editors. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2879-9.

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2

Kirslis, Peter Andre Christopher. The SAGA editor: A language-oriented editor based on an incremental LR(1) parser. Urbana, Ill: Dept. of Computer Science, University of Illinois at Urbana-Champaign, 1986.

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3

Lisa, Neal, and Szwillus Gerd, eds. Structure-based editors and environments. London: Academic Press, 1992.

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4

McDonald, Brendan. A java-based online database table editor. [s.l: The Author], 2001.

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5

Reps, Thomas W. Generating language-based environments. Cambridge, Mass: MIT Press, 2012.

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6

Sims, Darla. Making $$$ at home: Over 1000 editors who want your ideas, know-how & experience. Fairfield, Iowa: Sunstar Pub., 1996.

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7

Reps, Thomas W. The Synthesizer Generator: A System for Constructing Language-Based Editors. New York, NY: Springer New York, 1989.

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8

Tim, Teitelbaum, ed. The synthesizer generator: A system for constructing language-based editors. New York: Springer-Verlag, 1989.

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9

Jayasuriya, H. Kumar. Big data, big challenges in evidence-based policymaking / H. Kumar Jayasuriya, editor ; Kathryn Ritcheske, contributing editor. St. Paul, MN: West Academic Publishing, 2015.

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10

Shilling, John. Automated reference librarians for program [l]ibraries and their interaction with language based editors. Urbana, IL (1304 W. Springfield Ave., Urbana 61801): Dept. of Computer Science, University of Illinois at Urbana-Champaign, 1986.

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Частини книг з теми "Base editors"

1

Hwang, Gue-Ho, and Sangsu Bae. "Web-Based Computational Tools for Base Editors." In Methods in Molecular Biology, 13–22. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2879-9_2.

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2

Song, Beomjong, and Sangsu Bae. "Introduction and Perspectives of DNA Base Editors." In Methods in Molecular Biology, 3–11. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2879-9_1.

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3

Lim, Colin K. W., Angelo J. Miskalis, Pablo Perez-Pinera, and Thomas Gaj. "Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors." In Methods in Molecular Biology, 135–58. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2879-9_11.

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4

See, Ji-Eun, and Yongsub Kim. "Functional Analysis of Variants in BRCA1 Using CRISPR Base Editors." In Methods in Molecular Biology, 73–85. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2879-9_7.

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Kim, Daesik. "Profiling Genome-Wide Specificity of dCpf1 Cytidine Base Editors Using Digenome-Seq." In Methods in Molecular Biology, 33–40. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2879-9_4.

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Shyamli, P. Sushree, Sandhya Suranjika, Seema Pradhan, and Ajay Parida. "Recent Advances and Application of CRISPR Base Editors for Improvement of Various Traits in Crops." In Genome Editing, 105–31. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08072-2_5.

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Vosniadou, Stella, Erik De Corte, and Heinz Mandl. "Editors’ Introduction." In Technology-Based Learning Environments, 1–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79149-9_1.

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VanTassel-Baska, Joyce, and Catherine A. Little. "About the Editors." In Content-Based Curriculum for Advanced Learners, 669–70. 4th ed. New York: Routledge, 2022. http://dx.doi.org/10.4324/9781003310426-44.

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Bobek, Szymon, Grzegorz J. Nalepa, and Przemysław Babiarz. "Web-Based Editor for Structured Rule Bases." In Artificial Intelligence and Soft Computing, 411–21. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-59060-8_37.

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Hwang, K. A., D. C. Liu, and C. C. Lin. "BRUTUS: An Interactive Graphic Editor for IC Layout." In Computer-Based Automation, 95–117. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-7559-3_5.

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Тези доповідей конференцій з теми "Base editors"

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Holtmann, Jörg, Jan-Philipp Steghöfer, and Weixing Zhang. "Exploiting Meta-Model Structures in the Generation of Xtext Editors." In 11th International Conference on Model-Based Software and Systems Engineering. SCITEPRESS - Science and Technology Publications, 2023. http://dx.doi.org/10.5220/0011745900003402.

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McAleer, Michael. "Ranking the Leading Journals in Finance and Accounting Based on Quantity and Quality Citations." In 1st Electronic Conference of MDPI Editors-in-Chief. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/eic2015-b001.

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Pik To Cheung. "Manuscripts for the Evidence-Based Medicine Era." In Workshop on Publishing for Biomedical Journal Editors and Reviewers. Kuala Lumpur, Malaysia: Department of Biomedical Imaging, University of Malaya, 2006. http://dx.doi.org/10.2349/biij.2.4.e54-7.

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Russo, Andrea, Francesco Mazzeo Rinaldi, and Giovanni Giuffrida. "Information balance between newspapers and social networks." In CARMA 2020 - 3rd International Conference on Advanced Research Methods and Analytics. Valencia: Universitat Politècnica de València, 2020. http://dx.doi.org/10.4995/carma2020.2020.11635.

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Анотація:
Competing newspapers, after all, tend to publish the same information in agiven time frame. However, each editor tends to aggregate and present thenews according to certain criteria such as editorial policies, filteringstrategies, readers base, etc. Thus, the proper choice and filtering ofinformation makes one newspaper different from the other and, the propermanagement of such criteria, may deem the success or failure of a newspaper.From the editor’s perspective, the news selection process is a trade-offbetween informativeness and attractiveness, as determined by the readership.Could there be an optimal balance between these two conflicting forces?Moreover, is it possible that cultural and political inputs from social mediamay impact the news selection process?Political news on social networks represent nowadays a valuable informativeasset that gives the possibility to correlate newspaper information with publicrequest expressed on social networks. We believe that it is possible to developa theory to mitigate the newspaper’s cultural identity with the publicinformation needs collected on social media.In our work, we show how to measure the society request for information, andhow this can be conveyed.
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Kaiser, Katharina, Theresia Gschwandtner, and Patrick Martini. "MapFace - An Editor for MetaMap Transfer (MMTx)." In 2008 21st International Symposium on Computer-Based Medical Systems (CBMS). IEEE, 2008. http://dx.doi.org/10.1109/cbms.2008.116.

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6

Nakano, Marina, Emi Masuda, and Masaru Kamada. "A Structure Editor for the English Language." In 2016 19th International Conference on Network-Based Information Systems (NBiS). IEEE, 2016. http://dx.doi.org/10.1109/nbis.2016.38.

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Matsuo, Tokuro, Dzulqarnain Nasir, and Takayuki Fujimoto. "A Textbook Editor Based on a Customware Service." In 2009 International Conference on Network-Based Information Systems (NBIS). IEEE, 2009. http://dx.doi.org/10.1109/nbis.2009.7.

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Reps, Thomas W., Carla Marceau, and Tim Teitelbaum. "Remote attribute updating for language-based editors." In the 13th ACM SIGACT-SIGPLAN symposium. New York, New York, USA: ACM Press, 1986. http://dx.doi.org/10.1145/512644.512645.

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Vollebregt, Tobi, Lennart C. L. Kats, and Eelco Visser. "Declarative specification of template-based textual editors." In the Twelfth Workshop. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2427048.2427056.

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Citrin, Wayne, Daniel Broodsky, and Jeffrey McWhirter. "Style-based cut-and-paste in graphical editors." In the workshop. New York, New York, USA: ACM Press, 1994. http://dx.doi.org/10.1145/192309.192331.

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Звіти організацій з теми "Base editors"

1

Babenko, Vitalina O., Roman M. Yatsenko, Pavel D. Migunov, and Abdel-Badeeh M. Salem. MarkHub Cloud Online Editor as a modern web-based book creation tool. [б. в.], July 2020. http://dx.doi.org/10.31812/123456789/3858.

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Анотація:
The main criterion for the competitiveness of a teacher or expert in the field of science is a good ability to present their knowledge to students in an interactive form without spending a lot of time in preparation. The purpose of the study is to analyze modern editors to create educational information content in the modern educational space and to present a modern tool for creating web books based on the latest IT technologies. Modern editors of web material creation have been analyzed, statistics of situations on mastering of knowledge by listeners, using interactive methods of information submission have been investigated. Using the WYSIWYG concept and analyzing modern information tools for presenting graphic material, an effective tool for teaching interactive web material was presented. An adapted version of the MarkHub online editor based on cloud technologies is presented. Using MarkHub cloud-based online editor for the unified development of educational content can significantly increase the author’s productivity in the content creation process. At the same time, the effects of reducing the time spent on formatting the external presentation of the content, making synchronous changes to different versions of the content, tracking the versions of the content, organizing remote teamwork in the network environment are achieved.
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2

Ballance, Robert A. Design of the Pan Language-Based Editor. Fort Belvoir, VA: Defense Technical Information Center, February 1986. http://dx.doi.org/10.21236/ada173780.

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Vong, F. Motif-based display editor/manager (MEDM) operators guide. Office of Scientific and Technical Information (OSTI), November 1994. http://dx.doi.org/10.2172/204050.

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Blythe, Jim, and Surya Ramachandran. Knowledge Acquisition using an English-Based Method Editor. Fort Belvoir, VA: Defense Technical Information Center, January 1999. http://dx.doi.org/10.21236/ada459377.

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5

Mohan, Raj, Timothy E. Levin, and Cynthia E. Irvine. An Editor for Adaptive XML-Based Policy Management of IPsec. Fort Belvoir, VA: Defense Technical Information Center, December 2003. http://dx.doi.org/10.21236/ada435401.

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Bohuslavskyj, Oleh. UKRAINIAN-CANADIAN NEWSPAPER “NEW PATHWAY”: WINNIPEG PERIOD (1941-1977). Ivan Franko National University of Lviv, February 2022. http://dx.doi.org/10.30970/vjo.2022.51.11391.

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Анотація:
The subject of the study is the ideological, financial, economic and socio-social conditions of the publishing house and the editorial board of the magazine “New Pathway” Winnipeg period 1941-1977. The main objectives is to determine the peculiarities of the conditions of publishing a Ukrainian magazine in exile, which provides for the systematization and introduction into scientific circulation of factual material on creative and material activities of the “New Pathway” and socio-political environment that influenced the information and ideological and business policy of the publication. The basis of the research methodology is axiological, cultural, systemic approaches; methods of historicism, analysis, synthesis, generalization were used. The study provides not only a description of the historical path of the publication in this period, but also the reasons for miscalculations and successes, both financial and economic and socio-political, which allowed not only to stay in the information field and market for more than ninety years, technical circumstances of its existence, the political struggle in the new wave of emigration after World War II, changes in demographic and linguistic situation among the Ukrainian diaspora in Canada. The reasons for the situational increase and decrease in the activity of the publication’s subscribers were identified; the mechanisms of expanding the readership, attracting new readers and authors are analyzed; confirmed that the efforts of editors and directors of the publishing house at the initial stage of the Winnipeg period created and strengthened the material and technical base of the publishing house, conducted advertising campaigns and direct work to attract new subscribers and readers; The significance of the study is that for the first time in Ukraine the information about the Winnipeg period of the Ukrainian-Canadian weekly “New Pathway”, its financial and financial problems and creative and editorial successes was analyzed and summarized, thus filling another page in the history of Ukrainian diaspora periodicals.
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Li, Jia-Qi, PWH Kwong, YW Sun, WS So, and A. Sidarta. A comprehensive appraisal of meta-analyses in exercise-based stroke rehabilitation with trial sequential analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0006.

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Анотація:
Review question / Objective: This study aims to use the trial sequential analysis (TSA) method to examine if the published meta-analyses concerning stroke rehabilitation reached the required information size and if the overall effect size is robust as well. Condition being studied: Stroke rehabilitation. Eligibility criteria: Studies were included if they 1) were meta-analyses of random control trials (RCTs) on people with stroke, 2) included meta-analyses results in gait speed (or 6MWT) or bal-ance performance. Studies were excluded if they 1) were conference abstracts, letters to the editor 2) lack the statistical parameters such as mean, standard deviations (SD), and number value in the articles and raw data from the cited studies cannot be found.
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Bdzil, John Bohdan. DSD2D-FLS 2010: Bdzil's 2010 DSD Code Base; Computing tb and Dn with Edits to Reduce the Noise in the Dn Field Near HE Boundaries. Office of Scientific and Technical Information (OSTI), September 2016. http://dx.doi.org/10.2172/1327987.

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Prokhorov, Оleksandr V., Vladyslav O. Lisovichenko, Mariia S. Mazorchuk, and Olena H. Kuzminska. Developing a 3D quest game for career guidance to estimate students’ digital competences. [б. в.], November 2020. http://dx.doi.org/10.31812/123456789/4416.

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Анотація:
This paper reveals the process of creating a career guidance 3D quest game for applicants who aim to apply for IT departments. The game bases on 3D model of computer science and information technologies department in the National Aerospace University “Kharkiv Aviation Institute”. The quest challenges aim to assess the digital competency level of the applicants and first- year students. The paper features leveraged software tools, development stages, implementation challenges, and the gaming application scenario. The game scenario provides for a virtual tour around a department of the 3D university. As far as the game replicates the real-life objects, applicants can see the department's equipment and class-rooms. For the gaming application development team utilized С# and C++, Unity 3D, and Source Engine. For object modeling, we leveraged Hammer Editor, Agisoft PhotoScan Pro, and the photogrammetry technology, that allowed for realistic gameplay. Players are offered various formats of assessment of digital competencies: test task, puzzle, assembling a computer and setting up an IT-specialist workplace. The experiment conducted at the open house day proved the 3D quest game efficiency. The results of digital competence evaluation do not depend on the testing format. The applicants mostly preferred to take a 3D quest, as more up-to-date and attractive engagement.
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Modlo, Yevhenii O., Serhiy O. Semerikov, Stanislav L. Bondarevskyi, Stanislav T. Tolmachev, Oksana M. Markova, and Pavlo P. Nechypurenko. Methods of using mobile Internet devices in the formation of the general scientific component of bachelor in electromechanics competency in modeling of technical objects. [б. в.], February 2020. http://dx.doi.org/10.31812/123456789/3677.

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Анотація:
An analysis of the experience of professional training bachelors of electromechanics in Ukraine and abroad made it possible to determine that one of the leading trends in its modernization is the synergistic integration of various engineering branches (mechanical, electrical, electronic engineering and automation) in mechatronics for the purpose of design, manufacture, operation and maintenance electromechanical equipment. Teaching mechatronics provides for the meaningful integration of various disciplines of professional and practical training bachelors of electromechanics based on the concept of modeling and technological integration of various organizational forms and teaching methods based on the concept of mobility. Within this approach, the leading learning tools of bachelors of electromechanics are mobile Internet devices (MID) – a multimedia mobile devices that provide wireless access to information and communication Internet services for collecting, organizing, storing, processing, transmitting, presenting all kinds of messages and data. The authors reveals the main possibilities of using MID in learning to ensure equal access to education, personalized learning, instant feedback and evaluating learning outcomes, mobile learning, productive use of time spent in classrooms, creating mobile learning communities, support situated learning, development of continuous seamless learning, ensuring the gap between formal and informal learning, minimize educational disruption in conflict and disaster areas, assist learners with disabilities, improve the quality of the communication and the management of institution, and maximize the cost-efficiency. Bachelor of electromechanics competency in modeling of technical objects is a personal and vocational ability, which includes a system of knowledge, skills, experience in learning and research activities on modeling mechatronic systems and a positive value attitude towards it; bachelor of electromechanics should be ready and able to use methods and software/hardware modeling tools for processes analyzes, systems synthesis, evaluating their reliability and effectiveness for solving practical problems in professional field. The competency structure of the bachelor of electromechanics in the modeling of technical objects is reflected in three groups of competencies: general scientific, general professional and specialized professional. The implementation of the technique of using MID in learning bachelors of electromechanics in modeling of technical objects is the appropriate methodic of using, the component of which is partial methods for using MID in the formation of the general scientific component of the bachelor of electromechanics competency in modeling of technical objects, are disclosed by example academic disciplines “Higher mathematics”, “Computers and programming”, “Engineering mechanics”, “Electrical machines”. The leading tools of formation of the general scientific component of bachelor in electromechanics competency in modeling of technical objects are augmented reality mobile tools (to visualize the objects’ structure and modeling results), mobile computer mathematical systems (universal tools used at all stages of modeling learning), cloud based spreadsheets (as modeling tools) and text editors (to make the program description of model), mobile computer-aided design systems (to create and view the physical properties of models of technical objects) and mobile communication tools (to organize a joint activity in modeling).
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