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Добірка наукової літератури з теми "Atropie"

Автор: Grafiati
Опубліковано: 31 серпня 2024

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Статті в журналах з теми "Atropie"

1

Mitchell, Patrick O., and Grace K. Pavlath. "Skeletal muscle atrophy leads to loss and dysfunction of muscle precursor cells." American Journal of Physiology-Cell Physiology 287, no. 6 (December 2004): C1753—C1762. http://dx.doi.org/10.1152/ajpcell.00292.2004.

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Анотація:
Atrophy of skeletal muscle leads to decreases in myofiber size and nuclear number; however, the effects of atrophic conditions on muscle precursor cells (MPC) are largely unknown. MPC lie outside myofibers and represent the main source of additional myonuclei necessary for muscle growth and repair. In the present study, we examined the properties of MPC after hindlimb suspension (HS)-induced atrophy and subsequent recovery of the mouse hindlimb muscles. We demonstrated that the number of MPC in atrophied muscles was decreased. RT-PCR analysis of cells isolated from atrophied muscles indicated that several mRNA characteristic of the myogenic program in MPC were absent. Cells isolated from atrophied muscles failed to properly proliferate and undergo differentiation into multinucleated myotubes. Thus atrophy led to a decrease in MPC and caused dysfunction in those MPC that remained. Upon regrowth of the atrophied muscles, these deleterious effects were reversed. Our data suggest that preventing loss or dysfunction of MPC may be a new pharmacological target during muscle atrophy.
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2

Kim, Young In, Hyunjung Lee, Farida S. Nirmala, Hyo-Deok Seo, Tae Youl Ha, Chang Hwa Jung, and Jiyun Ahn. "Antioxidant Activity of Valeriana fauriei Protects against Dexamethasone-Induced Muscle Atrophy." Oxidative Medicine and Cellular Longevity 2022 (January 12, 2022): 1–16. http://dx.doi.org/10.1155/2022/3645431.

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Анотація:
Skeletal muscle atrophy is defined as wasting or loss of muscle. Although glucocorticoids (GCs) are well-known anti-inflammatory drugs, their long-term or high-dose use induces skeletal muscle atrophy. Valeriana fauriei (VF) is used to treat restlessness, anxiety, and sleep disorders; however, its effects on skeletal muscle health have not been investigated. This study investigated whether Valeriana fauriei could ameliorate muscle atrophy. We induced muscle atrophy in vitro and in vivo, by treatment with dexamethasone (DEX), a synthetic GC. In DEX-induced myotube atrophy, Valeriana fauriei treatment increased the fusion index and decreased the expression of muscle atrophic genes such as muscle atrophy F-box (MAFbx/Atrogin-1) and muscle RING-finger protein 1 (MuRF1). In DEX-treated mice with muscle atrophy, Valeriana fauriei supplementation increased the ability to exercise, muscle weight, and cross-sectional area, whereas it inhibited myosin heavy chain isoform transition and the expression of muscle atrophy biomarkers. Valeriana fauriei treatment led to via the downregulation of muscle atrophic genes via inhibition of GC receptor translocation. Valeriana fauriei was also found to act as a reactive oxygen species (ROS) scavenger. Didrovaltrate (DI), an iridoid compound from Valeriana fauriei, was found to downregulate atrophic genes and decrease ROS in the DEX-induced myotube atrophy. Consolidated, our results indicate that Valeriana fauriei prevents DEX-induced muscle atrophy by inhibiting GC receptor translocation. Further, Valeriana fauriei acts as a ROS scavenger, and its functional compound is didrovaltrate. We suggest that Valeriana fauriei and its functional compound didrovaltrate possess therapeutic potentials against muscle atrophy.
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3

Buckingham, Richard A. "Fascia and Perichondrium Atrophy in Tympanoplasty and Recurrent Middle Ear Atelectasis." Annals of Otology, Rhinology & Laryngology 101, no. 9 (September 1992): 755–58. http://dx.doi.org/10.1177/000348949210100907.

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Анотація:
Fascia and perichondrium grafts to replace and reinforce thin, atrophic tympanic membranes (TMs) are recommended by several authors to correct middle ear atelectasis by forming a fibrous, collapse-resistant TM. This study reviewed the status of connective tissue grafts performed over the 10-year period from 1979 to 1988 to determine if these grafts would maintain sufficient strength and fibrous character to resist recurrent atelectasis. The author used fascia or perichondrium to repair 89 TM defects, and 63 ears were available for follow-up: 54 had cholesteatomas and 9 had perforations. Graft atrophy was judged by microscopic otoscopy and Kodachrome otophotography. Fascia TM grafts atrophied in 35 of 43 ears (80%), and perichondrium atrophied in 8 of 20 ears (40%). Grafts maintained their relatively thick and fibrous character in only 20 of 63 ears (32%). If fascia and perichondrium used to correct atelectasis were to atrophy at the same rate as the grafts in this series, atelectasis would recur after attempts to reinforce atrophic TMs. Atelectasis-prone middle ears require intubation despite surgery.
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4

Nakao, Reiko, Katsuya Hirasaka, Jumpei Goto, Kazumi Ishidoh, Chiharu Yamada, Ayako Ohno, Yuushi Okumura, et al. "Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading." Molecular and Cellular Biology 29, no. 17 (June 22, 2009): 4798–811. http://dx.doi.org/10.1128/mcb.01347-08.

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Анотація:
ABSTRACT Skeletal muscle atrophy caused by unloading is characterized by both decreased responsiveness to myogenic growth factors (e.g., insulin-like growth factor 1 [IGF-1] and insulin) and increased proteolysis. Here, we show that unloading stress resulted in skeletal muscle atrophy through the induction and activation of the ubiquitin ligase Cbl-b. Upon induction, Cbl-b interacted with and degraded the IGF-1 signaling intermediate IRS-1. In turn, the loss of IRS-1 activated the FOXO3-dependent induction of atrogin-1/MAFbx, a dominant mediator of proteolysis in atrophic muscle. Cbl-b-deficient mice were resistant to unloading-induced atrophy and the loss of muscle function. Furthermore, a pentapeptide mimetic of tyrosine608-phosphorylated IRS-1 inhibited Cbl-b-mediated IRS-1 ubiquitination and strongly decreased the Cbl-b-mediated induction of atrogin-1/MAFbx. Our results indicate that the Cbl-b-dependent destruction of IRS-1 is a critical dual mediator of both increased protein degradation and reduced protein synthesis observed in unloading-induced muscle atrophy. The inhibition of Cbl-b-mediated ubiquitination may be a new therapeutic strategy for unloading-mediated muscle atrophy.
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5

MATTAR, Rejane, Sergio Barbosa MARQUES, Igor Braga RIBEIRO, Thiago Arantes de Carvalho VISCONTI, Mateus FUNARI, and Eduardo Guimarães Hourneaux DE MOURA. "DIAGNOSTIC ACCURACY OF GASTROPANEL® FOR ATROPHIC GASTRITIS IN BRAZILIAN SUBJECTS AND THE EFFECT OF PROTON PUMP INHIBITORS." Arquivos de Gastroenterologia 57, no. 2 (June 2020): 154–60. http://dx.doi.org/10.1590/s0004-2803.202000000-29.

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Анотація:
ABSTRACT BACKGROUND: It has been proposed that the combination of gastrin-17 (G-17), pepsinogens I and II (PGI and PGII), and anti-Helicobacter pylori (H. pylori) antibodies (GastroPanel®, BIOHIT HealthCare, Helsinki, Finland) could serve as biomarkers of atrophic gastritis. OBJECTIVE: This study aimed to ensure the diagnostic accuracy of GastroPanel® and evaluate the effect of proton pump inhibitors (PPIs) on these biomarkers. METHODS: Dyspeptic patients who underwent gastrointestinal endoscopy were enrolled in the present study. Histological findings, which were the gold standard to stratify groups, were as follows: no atrophy (controls); antrum atrophy; corpus atrophy; multifocal atrophy; and neoplasia. G-17, PGI, PGII, and anti-H. pylori immunoglobulin (Ig)G antibodies were assayed using commercially available kits. The ratio of PGI/PGII was calculated. RESULTS: Among 308 patients, 159 (51.6%) were PPI users. The overall prevalence of atrophy was 43.8% (n=135). Ninety-two (29.9%) patients were H. pylori positive according to anti-H. pylori IgG levels. G-17 levels were not low in those with antrum atrophy but were high in those with corpus and multifocal atrophies. PGI levels were significantly lower in those with corpus and multifocal atrophies. The sensitivity of PGI <30 µg/L to detect corpus atrophy was 50% (95% CI 27.8-72.1%), with a specificity of 93.2% (95% CI 84.3-97.5%), a positive likelihood ratio of 7.4 (95% CI 2.9-19.2), and a negative likelihood ratio of 0.5 (95% CI 0.3-0.8). A small number of subjects (n=6) exhibited moderate to intense atrophy (4%), among whom 66.7% exhibited decreased PGI levels. PPI significantly increased the levels of G-17 and PGI, except in those with corpus and multifocal atrophies, in whom PGI levels were not increased by PPIs. CONCLUSION: GastroPanel® (Gastrin-17, PGI, and PGI/PGII ratio) did not demonstrate high sensitivity for detecting gastric atrophy.
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6

Le, Ngoc Hoan, Chu-Sook Kim, Taesun Park, Jung Han Yoon Park, Mi-Kyung Sung, Dong Gun Lee, Sun-Myung Hong, et al. "Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy." Mediators of Inflammation 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/834294.

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Анотація:
Skeletal muscle inflammation and atrophy are closely associated with metabolic impairment such as insulin resistance. Quercetin, a natural polyphenol flavonoid, is known to elicit anti-inflammatory and antioxidant activities. In this study, we investigated its effect on obesity-induced skeletal muscle inflammation and atrophy in mice. Male C57BL/6 mice were fed a regular diet, a high-fat diet (HFD), and an HFD supplemented with quercetin for nine weeks. Quercetin reduced levels of inflammatory cytokines and macrophage accumulation in the skeletal muscle of the HFD-fed obese mice. It also reduced transcript and protein levels of the specific atrophic factors, Atrogin-1 and MuRF1, in the skeletal muscle of the HFD-fed obese mice, and protected against the reduction of muscle mass and muscle fiber size. In vitro, quercetin markedly diminished transcript levels of inflammatory receptors and activation of their signaling molecules (ERK, p38 MAPK, and NF-κB) in cocultured myotubes/macrophages, and this was accompanied by reduced expression of the atrophic factors. Together, these findings suggest that quercetin reduces obesity-induced skeletal muscle atrophy by inhibiting inflammatory receptors and their signaling pathway. Quercetin may be useful for preventing obesity-induced muscle inflammation and sarcopenia.
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7

Lee, Jun Ho, Jung Yoon Jang, Young Hoon Kwon, Seung Ho Lee, Cheol Park, Yung Hyun Choi, and Nam Deuk Kim. "Effects of Rosemary Extract on C2C12 Myoblast Differentiation and 5-Aminoimidazole-4-carboxamide Ribonucleoside (AICAR)-Induced Muscle Cell Atrophy." Applied Sciences 13, no. 2 (January 11, 2023): 986. http://dx.doi.org/10.3390/app13020986.

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Анотація:
Sarcopenia is an aging-related disease that involves the gradual loss of muscle mass and function. However, no suitable therapeutic drugs are currently available. Accordingly, the purpose of the present study was to evaluate the effectiveness of rosemary extract (RE) in inducing myotube differentiation and inhibiting 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced muscle atrophy in mouse C2C12 cells. Morphological changes associated with the onset of RE-induced differentiation were evaluated by measuring myotube diameter, and the expression of proteins related to muscle differentiation and atrophy was measured using western blot analysis. Treatment with RE increased myotube thickness and the expression of the myogenic differentiation 1 (MyoD) and myogenin proteins. The effect of RE treatment on 5′-adenosine monophosphate-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), MyoD, myogenin, muscle atrophy factors forkhead box O3a (FoxO3a), MAFbx/atrogin-1, and muscle RING finger-1 (MuRF-1) protein expression in AICAR-induced muscle-atrophied C2C12 cells was evaluated using western blot analysis. Treatment with RE reduced FoxO3a, MAFbx/atrogin-1, and MuRF-1 expression and significantly increased MyoD and myogenin expression. These findings suggest that RE has the potential to be used as an active ingredient in sarcopenia treatments.
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8

Madahi, Mehdi, Reza Gharakhanlou, Abdolreza Kazemi, and Mohammad Ali Azarbayjani. "Effect of Reduced Physical Activity on Murf-1 and Atrogin-1 Gene Expression in Soleus Muscle of Wistar Rats Following Endurance, Resistance and Combined Training." Scientific Journal of Rehabilitation Medicine 11, no. 2 (May 22, 2022): 250–63. http://dx.doi.org/10.32598/sjrm.11.2.9.

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Анотація:
Background and Aims Understanding the involved mechanisms in muscle atrophy can help develop new treatment methods for atrophic conditions. Skeletal muscle atrophy via biochemical and transcriptional pathways can increase the expression of some muscle atrophy related genes. The present study aims to assess the effect of reduced physical activity by the spinal nerve ligation (SNL) after a period of resistance, endurance and combined exercises on the expression of MuRF-1 and Atrogin-1 genes in male rats. Methods In this experimental study, 30 male Wistar rats were randomly divided into four groups: Control+SNL, combined exercise+SNL, endurance exercise+SNL, and resistance training+SNL. The exercises were performed for six weeks. After this period, the protocol of reduced physical activity by the SNL was implemented for four weeks. At the end, soleus muscle was isolated and the expression levels of MuRF-1 and Atrogin-1 genes were measured by real-time polymerase chain reaction technique. To examine the gene expression differences between the groups, analysis of variance and Tukey’s post hoc test were used. The significant level was set at 0.05. Results The results showed that the expression of MuRF-1 gene in the combined exercise+SNL and resistance training+SNL groups was significantly lower than in the control group (P<0.05). The Atrogin-1 gene expression was significantly reduced only in the combined exercise+SNL group compared to the control group (P<0.05). Conclusion It seems that the rats with resistance training are more resistant to SNL-induced atrophy than the group with endurance exercise.
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9

Aravena, Javier, Johanna Abrigo, Francisco Gonzalez, Francisco Aguirre, Andrea Gonzalez, Felipe Simon та Claudio Cabello-Verrugio. "Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy". International Journal of Molecular Sciences 21, № 3 (10 лютого 2020): 1167. http://dx.doi.org/10.3390/ijms21031167.

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Анотація:
Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. The main pathway that mediates protein degradation during muscle atrophy is the ubiquitin proteasome system, by increasing the expression of atrogin-1 and MuRF-1. In addition, myostatin activates the NF-κB signaling pathway. Renin–angiotensin system (RAS) also regulates muscle mass. Angiotensin (1-7) (Ang-(1-7)) has anti-atrophic properties in skeletal muscle. In this paper, we evaluated the effect of Ang-(1-7) on muscle atrophy and signaling induced by myostatin. The results show that Ang-(1-7) prevented the decrease of the myotube diameter and myofibrillar protein levels induced by myostatin. Ang-(1-7) also abolished the increase of myostatin-induced reactive oxygen species production, atrogin-1, MuRF-1, and TNF-α gene expressions and NF-κB signaling activation. Ang-(1-7) inhibited the activity mediated by myostatin through Mas receptor, as is demonstrated by the loss of all Ang-(1-7)-induced effects when the Mas receptor antagonist A779 was used. Our results show that the effects of Ang-(1-7) on the myostatin-dependent muscle atrophy and signaling are blocked by MK-2206, an inhibitor of Akt/PKB. Together, these data indicate that Ang-(1-7) inhibited muscle atrophy and signaling induced by myostatin through a mechanism dependent on Mas receptor and Akt/PKB.
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10

Zou, Yun-Yi, Zhang-Lin Chen, Chen-Chen Sun, Dong Yang, Zuo-Qiong Zhou, Qin Xiao, Xi-Yang Peng, and Chang-Fa Tang. "A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity." Nutrients 14, no. 9 (May 9, 2022): 1975. http://dx.doi.org/10.3390/nu14091975.

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Анотація:
Obesity is a highly prevalent disease that can induce metabolic syndrome and is associated with a greater risk of muscular atrophy. Mitochondria play central roles in regulating the physiological metabolism of skeletal muscle; however, whether a decreased mitochondrial function is associated with impaired muscle function is unclear. In this study, we evaluated the effects of a high-fat diet on muscle mitochondrial function in a zebrafish model of sarcopenic obesity (SOB). In SOB zebrafish, a significant decrease in exercise capacity and skeletal muscle fiber cross-sectional area was detected, accompanied by high expression of the atrophy-related markers Atrogin-1 and muscle RING-finger protein-1. Zebrafish with SOB exhibited inhibition of mitochondrial biogenesis and fatty acid oxidation as well as disruption of mitochondrial fusion and fission in atrophic muscle. Thus, our findings showed that muscle atrophy was associated with SOB-induced mitochondrial dysfunction. Overall, these results showed that the SOB zebrafish model established in this study may provide new insights into the development of therapeutic strategies to manage mitochondria-related muscular atrophy.
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Більше джерел

Дисертації з теми "Atropie"

1

Koetz, Mariana. "Desenvolvimento e validação de métodos analíticos para determinação do teor de atropina em folhas de Atropa belladonna (L.) solanaceae." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164716.

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Анотація:
A atropina é um alcaloide conhecido pela inibição da acetilcolina e como substância antimuscarínica e está presente em folhas de algumas espécies da família Solanaceae, e, em especial, da Atropa belladonna L. A importância da produção de fitoterápicos na indústria farmacêutica tem impulsionado estudos científicos no sentido de desenvolver metodologias analíticas para quantificação de marcadores químicos, presentes em drogas vegetais, e que atendam os parâmetros de controle de qualidade da legislação vigente. Assim, neste trabalho, diferentes metodologias para quantificação da atropina (marcador químico predominante nas folhas de A. belladonna) foram desenvolvidas e validadas. Os métodos propostos por Cromatografia em Camada Delgada de Alta Eficiência (CCDAE), Cromatografia a Líquido de Alta Eficiência (CLAE) e Cromatografia a Líquido de Ultra Eficiência (CLUE) foram validados comprovando ter especificidade/seletividade, linearidade, precisão, exatidão e robustez e adequando-se à legislação vigente. Além disso, diferentes métodos de extração foram propostos. Para o primeiro método de análise (CCDAE), uma extração com ácido diluído (H2SO4 0,5 mol/L), seguida de extração líquido-líquido foi utilizada, resultando em teor médio de 0,2913 % de atropina. Para o segundo (CLAE), uma extração com solvente apolar (metanol p.a.) foi proposta, seguida também de extração líquido-líquido e com teor médio de 0,2660 % do ativo. No terceiro (CLUE), otimização de extração foi realizada através de Desenho Fatorial Fracionado, seguido de Desenho Box-Behnken, resultando em extração realizada pela mistura de solvente apolar e água (metanol 47 %), seguido de uma extração em fase sólida (sílica) e um teor de atropina médio de 0,3343 %. Um extrato otimizado foi analisado nos três métodos, resultando em teores de atropina iguais a 0,2905, 0,3598 e 0,3343 % para CCDAE, CLAE e CLUE, respectivamente. A revisão da monografia do material vegetal, com ensaios de identificação e físico-químicos, juntamente com a metodologia de doseamento por Cromatografia a Líquido de Alta Eficiência foi proposta com o objetivo de atualizar as metodologias que hoje compõe o roteiro de controle de qualidade da espécie na Farmacopeia Brasileira, que está em sua 5° edição.
Atropine is an alkaloid known for acetylcholine inhibition and as antimuscarinic substance and is present in leaves of some species of the family Solanácea, and especially of Atropa belladonna L. The importance of the production of herbal medicines in the pharmaceutical industry has driven scientific studies to develop analytical methods for quantification of chemical markers, present in herbal drugs, and that meet the quality control parameters of the current legislation. Thus, in this work, different methodologies for quantification of atropine (chemical marker predominant in the leaves of A. belladonna) were developed and validated. The methods proposed by High Performance Thin-layer Chromatography (HPTLC), High Performance Liquid Chromatography (HPLC) and Ultra Performance Liquid Chromatography (UPLC) were validated proving to have specificity/selectivity, linearity, precision, accuracy and robustness, and conforming to legislation. In addition, different extraction methodologies were proposed. For the first method of analysis (CCDAE), extraction with dilute acid (H2SO4 0.5 mol/L) followed by liquid-liquid extraction was used, resulting in an average content of 0.2913% atropine. For the second (HPLC), extraction with apolar solvent (methanol p.a.) was proposed, followed also by liquid-liquid extraction and with an average content of 0.2660% of the active. In the third (CLUE), optimization of extraction was done through Fractional Factorial Design, followed by Box-Behnken Design resulting in extraction by the apolar solvent mixture and Water (47% methanol), followed by solid phase extraction (silica) and an average atropine content of 0.3343%. An optimized extract was analyzed in three methods, resulting in atropine levels equal to 0.2905, 0.3598 and 0.3334 % for HPTLC, HPLC and UPLC, respectively. The review of the monograph of the plant material, with identification and physicochemical tests, together with the methodology of determination by HPLC was proposed with the objective of updating the methodologies that today compose the roadmap of quality control of specie in Brazilian Pharmacopoeia, which is in its 5th edition.
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2

Dessalle, Kévin. "Régulation du métabolisme musculaire par les facteurs de transcription SREBP-1 : rôle des MRFs, de SIRT1 et des céramides." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00794521.

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Анотація:
Les protéines SREBP-1 sont des facteurs de transcription connus pour leur rôle dans la régulation du métabolisme lipidique. Plus récemment des études faites in vitro (myotubes humains en culture primaire) et in vivo (muscle tibial de souris) ont montré que la surexpression de SREBP-1a ou SREBP-1c induit une atrophie musculaire et bloque la différenciation musculaire, en inhibant notamment l'expression des protéines structurales du muscle squelettique et des facteurs de la différenciation musculaire (MRFs). Les travaux de thèse présentés dans ce manuscrit ont eu pour but de décrypter le mécanisme de l'atrophie induite par SREBP-1 et de déterminer comment les protéines SIRT1 pourraient réguler ce facteur de transcription. L'atrophie musculaire résulte d'un déséquilibre entre la quantité de protéines synthétisées et dégradées. Dans nos études, nous montrons que SREBP-1 régule la synthèse protéique et la dégradation protéique, respectivement via le contrôle négatif de l'expression des MRFs et via le contrôle de l'expression des atrogènes, MuRF1 et Atrogin-1. Dans le muscle squelettique, nous démontrons que la désacétylase SIRT1 régule l'activité transcriptionnelle de SREBP-1. Les protéines SREBP-1 et SIRT1 étant toutes deux impliquées dans la régulation du métabolisme lipidique, nous mettons en évidence une nouvelle voie de signalisation reliant le métabolisme énergétique et nutritionnel avec l'activité transcriptionnelle de SREBP-1 dans le muscle. Étant donné le rôle de SIRT1 et SREBP-1 dans le métabolisme lipidique et musculaire, nous nous sommes intéressés au rôle des phospholipides et plus particulièrement des céramides dans la régulation de la masse musculaire.Nos études montrent que la régulation de la quantité de céramides par la cytokine TNFα régule la masse musculaire. Ainsi, nos travaux mettent en évidence de nouveaux liens entre le métabolisme lipidique et la régulation de la masse et du métabolisme musculaire.
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3

Brasil, Antonio Augusto Azevedo Vital. "Atrofia prostática em espécimes de prostatectomia radical = há relação topográfica com neoplasia intraepitelial prostática alto grau e adenocarcinoma?" [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308454.

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Анотація:
Orientadores: Athanase Billis, Luciana Rodrigues de Meirelles
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A relação entre a atrofia inflamatória com a neoplasia intraepitelial alto grau e o carcinoma, é controversa. Tem sido sugerida uma relação topográfica e que o epitélio proliferativo da atrofia inflamatória possa progredir para neoplasia intraepitelial prostática alto grau (NIPAG) e/ou carcinoma (CA). O propósito do nosso estudo foi analisar em espécimes de prostatectomia radical uma possível relação topográfica entre estas lesões. Um total de 3186 quadrantes pertencentes a 100 prostatectomias radicais completamente representadas, foi analisado. Determinou-se a frequência de quadrantes mostrando: somente atrofia inflamatória (AI), AI+CA, AI+NIPAG, ou AI+NIPAG+CA. A extensão e a distância entre as lesões foram avaliadas através de um método semiquantitativo de contagem de pontos previamente descrito. Também foram analisados focos de atrofia completa ou parcial sem inflamação. Os métodos estatísticos empregados foram os testes de Kruskal-Wallis e Mann-Whitney, e o coeficiente de correlação de Spearman. A média dos quadrantes exibindo somente AI, AI+CA, AI+NIPAG, e AI+NIPAG+CA foi 3.29, 2.51, 0.77, e 0.44; e a amplitude (0-21), (0-11), (0-6), (0-4), respectivamente (p<0.01). A maioria dos focos de AI estavam a uma distância >5mm dos focos de NIPAG e CA. Não houve correlação significativa entre a extensão da AI (p= 0.64, r= 0.05) com a extensão da NIPAG. Houve uma significativa correlação negativa entre a extensão da AI (p=0.01, r=-0.27) com a extensão do CA. Resultados similares foram encontrados considerando focos de atrofia com ou sem inflamação. Focos de atrofia parcial não evidenciaram inflamação crônica inespecífica. Nosso estudo não evidenciou associação topográfica significativa entre AI, NIPAG e/ou CA
Abstract: It is controversial whether there is any relationship of proliferative inflammatory atrophy (PIA) to high-grade prostatic intraepithelial neoplasia (HGPIN) and cancer (CA). It has been suggested a topographic relation and a potential of the proliferative epithelium in PIA to progress to HGPIN and/or CA. The aim of this study was to analyze in radical prostatectomies a possible topographic relation of the lesions. A total of 3186 quadrants from 100 whole-mount consecutive surgical specimens was examined. The frequency of quadrants showing: only PIA, PIA+CA, PIA+HGPIN, or PIA+HGPIN+CA was determined. Extent and distance between the lesions were evaluated by a semiquantitative point-count method previously described. We also studied foci with partial or complete atrophy without inflammation. The statistical methods included the Kruskal-Wallis and the Mann-Whitney tests and the Spearman correlation coefficient. The mean (range) of quadrants showing only PIA, PIA+CA, PIA+HGPIN, and PIA+HGPIN+CA was 3.29 (0-21), 2.51 (0-11), 0.77 (0-6), and 0.44 (0-4), respectively (p<0.01). Most of the foci of PIA were significantly located in a distance >5mm than <5mm from HGPIN or CA. There was no significant correlation between extent of PIA (p=0.64, r=0.05) with extent of HGPIN. There was a significant negative correlation of extent of PIA (p=0.01, r=-0.27) with extent of CA. Similar results were found considering foci either with or without inflammation. Chronic inespecific inflammation was not seen in foci of partial atrophy. A topographic relation of PIA to HGPIN and/or CA was not supported by our study
Mestrado
Anatomia Patologica
Mestre em Ciências Médicas
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4

Fernandes, Daniela Alves 1985. "Relação entre volume hipocampal e volume de ressecção cirúrgica com controle de crises e desempenho de memória em pacientes com epilepsia de lobo temporal mesial submetidos a tratamento cirúrgico." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309284.

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Анотація:
Orientador: Fernando Cendes
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A epilepsia é a segunda patologia neurológica que mais afeta a população mundial e a epilepsia do lobo temporal é a mais comum das epilepsias focais com maior frequência, associada à refratariedade e a distúrbios de memória. A lesão epileptogênica pode ser estudada através de imagens de ressonância magnética (RM), EEG entre outros exames, facilitando a indicação da cirurgia que tem como objetivo reduzir as crises, entretanto a função cognitiva pode ser afetada. Nosso propósito foi avaliar a eficácia da cirurgia quanto ao controle das crises, desempenho de memória nos pacientes e comparar os resultados de avaliações neuropsicológicas pré e pós-operatórias quanto à frequência de crises, abordagem cirúrgica e volumetria da estrutura e lacuna. Foram analisados 55 pacientes submetidos à cirurgia de epilepsia e 29 indivíduos controles saudáveis. Todos foram submetidos à aquisição de imagens em um aparelho de RM 2T em dois tempos com intervalos médios de 4,4±2,8 anos. A volumetria do hipocampo e lacuna cirúrgica foi realizada com o software Display, utilizando o protocolo de Bonilha et at., 2004. Os pacientes foram avaliados de acordo com a classificação pós-operatória de Engel Jr., 1997 e testes de avaliações neuropsicológicas que incluiu subtestes: da Wechsler Memory Scale-Revised; Wechsler Adult Intelligence Scale-Revised e Rey Auditory Verbal Learning Test, realizados com um intervalo médio de 8,5 anos após a cirurgia. Para análise dos dados pré/pós-operatórios foi utilizado o teste T de Student, de Wilcoxon ou Man-Whitney, correlação de Pearson e Spearman de acordo com as características das variáveis. Observamos diferença significativa nas avaliações neuropsicológicas, quando comparadas entre os próprios indivíduos nos grupos pré e pós-operatório e nos grupos de acordo com a Escala de Engel e lado da cirurgia, com piora no desempenho cognitivo no período pós-operatório. Mostraram melhora no desempenho de memória os que foram classificados em Engel IA quando comparados aos indivíduos que continuaram com crises. Os grupos submetidos à amigdalohipocampectomia seletiva e ressecção cortical associada à amigdalohipocampectomia não apresentaram diferenças significativas quanto ao desempenho de memória. O grau de escolaridade influenciou negativamente no resultado das avaliações. Nossos resultados mostraram que 80% foram classificados em Engel I, 18,2% em Engel II e 1,8% em Engel III. A volumetria dos hipocampos direito e esquerdo ipsilaterais à cirurgia apresentaram valores menores que dos controles. Os hipocampos esquerdos e direitos pré/pósoperatórios contralaterais à atrofia não apresentaram resultado significativo quando comparado as volumetrias dos controles e nem quando comparados entre si. Os dados de volumetria associados à memória apresentaram grau razoável e moderado de correlação. Nossos resultados mostraram que após a ressecção cirúrgica existe um declínio no desempenho de memória, porém a frequência de crises desses pacientes diminui significativamente e que o tipo de abordagem cirúrgica não interfere no desempenho de memória, mesmo com o maior volume da ressecção de pacientes submetidos à lobectomia temporal anterior
Abstract: Epilepsy is the second most frequent neurological disease and temporal lobe epilepsy is the most common form of focal epilepsy and is more frequently associated to refractoriness and memory decline. The epileptogenic lesion can be studied through magnetic resonance imaging, EEG and other tests, facilitating the indication of surgery that aims to reduce seizure frequencies, however cognitive function may be affected. We proposed to evaluate the effectiveness of surgery on the management of seizures, memory performance and compare the results of neuropsychological assessments pre/post-operative and the frequency of seizures, surgical approach and volume of hippocampi and amount of resection. We analyzed 55 patients who underwent epilepsy surgery and 29 healthy control subjects. All patients underwent imaging in a 2T MR scanner in two steps with intervals of 4.4 ± 2.8 years. The volumetry of the hippocampus and surgery gap was done with the software display, using the protocol described by Bonilha et al, 2004. Patients were evaluated according to the postoperative classification of Engel Jr., 1997 and neuropsychological evaluation that included the subtests, Wechsler Memory Scale-Revised, Wechsler Adult Intelligence Scale-Revised and Rey Auditory Verbal Learning Test, performed with an average interval 8.2 years after surgery. For data analysis, pre/post-operative we used the Student t test, Wilcoxon or Man-Whitney, Pearson and Spearman correlation test according to the characteristics of variables. We observed significant differences in neuropsychological evaluations, when we compared the groups pre/post-operative and the groups according to the Engel Scale and side of surgery, with worsening of cognitive performance in the postoperative period. There was a relative improvement in memory performance in those who were classified as Engel IA compared to individuals who continued to have seizures. The comparisons between the groups of selective amygdalohippocampectomy and anterior temporal lobe resection showed no significant differences in memory performance. The level of education had a negative influence on the outcome of neuropsychological evaluations. Our results showed that 80% were classified as Engel I, 18.2% in Engel II and 1.8% in Engel III. The volumetry of the left and right hippocampi ipsilateral to the surgery showed lower values than controls. The left and right hippocampus pre/post-operative contralateral to the side of surgery did not show significant differences when compared to controls. There was a correlation between hipocampal volumes and memory performance. Our results showed that after surgical resection there is a decline in memory performance, but the frequency of seizures in these patients decreased significantly and that the types of surgical approaches do not differ in terms of post-operative nor the total volume of the surgical lacunae
Mestrado
Neurociencias
Mestre em Ciências
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5

Freire, Simei André da Silva Rodrigues 1981. "Tratamento de fraturas de mandíbulas atróficas : estudo epidemiológico, mecânico e análises de elementos finitos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289615.

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Анотація:
Orientador: Luciana Asprino
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O objetivo desse trabalho foi avaliar a epidemiologia e características do tratamento de fraturas de mandíbula atrófica; comparar a resistência mecânica e a distribuição de tensões de três técnicas de fixação interna aplicadas em fraturas de mandíbulas atróficas. CAPÍTULO I: Dados foram coletados de pacientes vítimas de fraturas em mandíbulas atróficas em um período de dez anos (1999-2009). Os dados analisados continham informações demográficas e socioeconômicas, etiologia dos traumas, diagnóstico, tipos de traumas, deslocamento das fraturas, o método de fixação utilizado, região das fraturas, traumas associados, tempo decorrido entre o trauma e tratamento. A principal causa das fraturas em mandíbulas atróficas foi a queda da própria altura, acometendo principalmente pacientes do gênero masculino desempregados. A faixa etária mais acometida foi a de trinta a sessenta anos ocorrendo predominantemente fraturas bilaterais na região de corpo mandibular. CAPÍTULO II: Avaliou-se a resistência, in vitro, por meio de testes de carregamento linear a fixação de fraturas de mandíbulas atróficas com defeito de continuidade por meio de três sistemas de fixação. Foram utilizadas réplicas de mandíbulas humanas atróficas de poliuretano submetidas a simulação de fratura com defeito de continuidade de 15mm em corpo direito, fixadas pelos seguintes sistemas: Grupo 1 - sistema 2,4mm conventional, Grupo 2 - sistema 2,4 mm com travamento e Grupo 3 - sistema 2,0mm com travamento. Pelos resultados obtidos o sistema com travamento aumentou a resistência da fixação pela melhor e mais favorável distribuição de cargas, os sistemas 2,4mm de fixação interna estável testados apresentaram adequada resistência mecânica para tratamento de fraturas de mandíbulas atróficas com defeito de continuidade. CAPÍTULO III: Avaliou-se, in sílico, pelo método de elementos finitos a fixação de fraturas de mandíbulas atróficas por meio de três sistemas de fixação submetidas a testes de carregamento linear. Os modelos criados em elementos finitos de fratura de mandíbula atrófica foram fixados pelos seguintes sistemas, sistema 2,4mm convencional, sistema 2,4mm com travamento e sistema 2,0mm com travamento. Pelos resultados obtidos o sistema 2,4mm convencional demonstrou suportar toda carga aplicada nesta simulação, os sistemas com travamento apresentaram dissipação das tensões para região anterior e posterior da mandíbula e no sistema de fixação convencional as tensões se localizaram na porção entre os furos do sistema de fixação assim como no sistema com travamento, porém este ainda apresentou dissipação para os parafusos, com concentração crescente para região apical dos parafusos próximos a simulação do traço de fratura
Abstract: The aim of this study was to evaluate the epidemiology and treatment characteristics of atrophic mandibular fractures; to compare the mechanical strength and stress distribution of three internal fixation techniques applied in atrophic mandibles fractures treatment. CHAPTER I: Data were collected from patients suffering from atrophic mandibles fractures in a period of ten years (1999-2009). The data analyzed contained demographic and socioeconomic characteristics, etiology of trauma, diagnosis, types of trauma, displacement of the fractures, the region of fracture, associated trauma, time elapsed between trauma and treatment. The main cause of fractures in atrophic mandibles was fall accidents, affecting mainly male unemployed patients. The age group most affected was between thirty to sixty years occurring bilateral fractures predominantly in the mandibular body region. CHAPTER II: Resistance was evaluated in vitro by linear loading test in the atrophic mandible fracture simulation with continuity defect by three stable internal fixation systems. It was used replicas of human atrophic polyurethane mandible subjected to simulated fracture defect continuity of 15mm in right body region, fixed by the following systems: Group 1 - 2.4mm conventional system, Group 2 - 2.4 mm locking system and Group 3 - 2.0mm locking system. The results obtained with the locking system increased the resistance setting for the better and more favorable load distribution, the 2.4mm stable internal fixation systems tested had adequate mechanical strength for the treatment of fractures of atrophic mandibles with continuity defects. CHAPTER III: It was evaluated ,in silico, by the method of finite elements with linear force three stable internal fixation systems for the treatment of atrophic mandible fractures. The finite element models created in the atrophic mandible fracture were fixed by the following systems, the conventional system 2.4mm, 2.4mm locking system and 2.0mm locking system. The results obtained demonstrated that the locking system increased the resistance by a favorable and better distribution of the stresses during the loading test when applied in atrophic mandible fractures with continuity defects. The three internal fixation systems tested in this study showed adequate mechanical efficiency to be applied in atrophic mandible fractures with continuity defects treatment
Doutorado
Cirurgia e Traumatologia Buco-Maxilo-Faciais
Doutor em Clínica Odontológica
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6

Fernandes, Daniela Alves 1985. "Avaliação da tractografia, relaxometria T2 e volumetria hipocampal e sua relação com o controle de crises e alterações de memória em pacientes com epilepsia de lobo temporal mesial submetidos ao tratamento cirúrgico = Tractography assessment, T2 relaxometry and hippocampal volume and its relation to the control of seizures and memory impairment in patients with mesial temporal lobe epilepsy underwent surgical treatment." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312638.

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Анотація:
Orientador: Fernando Cendes
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A quantificação da atrofia das estruturas temporais mesiais pelas imagens de RM em pacientes com ELTM permite a identificação "in vivo" das alterações anatômicas associadas à esta patologia e sua correlação com dados neuropsicológicos, permitem a definição de um bom diagnóstico. Apesar da comprovação da eficácia do tratamento cirúrgico para o controle das crises, ainda não são claros os efeitos da ressecção de estruturas mesiais do lobo temporal na performance cognitiva, a longo prazo. O objetivo deste trabalho foi realizar um estudo prospectivo de uma série de pacientes com ELTM submetidos ao tratamento cirúrgico, comparando os resultados pré/pós-cirúrgicos obtidos a partir da análise de dados de avaliação neuropsicológica (ANP) e imagens de RM. No estudo avaliamos 119 indivíduos, 88 pacientes e 31 controles saudáveis. Os pacientes foram classificados de acordo com a escala proposta por Engel para controle de crises após a cirurgia. Avaliamos o coeficiente de inteligência estimado (QIe), as memórias verbal e não verbal com testes utilizados na rotina de investigação pré-operatória do nosso serviço. Utilizamos análises longitudinais específicas realizadas com o software SPSS®22. Consideramos p?0,05. Quanto à classificação de Engel observamos que 73,7% dos pacientes foram classificados em Engel I; 17,1% foram classificados em Engel II; 8,0% foram classificados em Engel III e 1,1% classificado em Engel IV com tempo médio de seguimento de 8,8 anos após a cirurgia. Para as ANP pré/pós-operatória observamos um declínio de memória para esses pacientes relacionado ao controle de crises e lado da cirurgia (p<0,0001). Para as ANP pós-operatórias realizadas em dois tempos diferentes e separadas em grupos quanto ao controle de crises e lado da cirurgia, não observamos diferença significativa, entretanto todos os testes indicaram uma tendência de melhora no desempenho de memória e QIe. Observamos maior volume hipocampal para os controles (média=3706±842), volume reduzido do hipocampo contralateral para pacientes livre de crises (média=3602±711) e menor ainda para os pacientes com presença de crises (média=3284±521). Para a análise de intensidade de sinal no lobo temporal contralateral dos pacientes, observamos uma diferença significativa (p=0,005) entre controles e pacientes com média menor para os controles. Também observamos alterações com diferença significativa para os tratos analisados em imagens de DTI, no lado ipsilateral à cirurgia comparados aos controles. Nossos resultados mostram bom controle de crises após a cirurgia, mesmo após um longo período. Entretanto observamos que após a cirurgia existe um declínio na performance dos testes neuropsicológicos para muitos pacientes, independente do lado operado. Porém, a análise a longo prazo mostra que existe uma recuperação parcial desse declínio, que pode estar associada a interação entre fatores de aprendizado e plasticidade cerebral; ou seja, podemos inferir que de alguma forma a melhora no controle das crises permite uma "recuperação" da eficiência cognitiva a longo prazo
Abstract: The quantification of the atrophy of the mesial temporal structures by MR images in patients with TLE allows identification "in vivo" of the anatomical changes associated with this disease and its correlation with neuropsychological data, allowing for the establishment of a proper diagnosis. Despite the evidence of the effectiveness of surgical treatment for seizure control, it is not yet clear the effects of resection of the mesial temporal lobe structures in cognitive performance in the long-term follow up. The aim of this study was to evaluate prospectively of a series of patients with TLE undergoing epilepsy surgery, comparing pre/post-surgical results obtained from neuropsychological assessment (NPA). We included 119 subjects, 88 patients and 31 healthy controls. Of the 113 patients, 88 had two NPA and 60 underwent two MRIs after surgery. Patients were classified according to Engel¿s scale. We evaluated the estimated intelligence coefficient (eIQ), the verbal and non-verbal memories with tests used in preoperative routine. We use specific longitudinal analyzes with SPSS®22 software. We observed that 73.7% of patients were classified as Engel I; 17.1% were classified as Engel II; 8.0% were classified as Engel III and 1.1% classified as Engel IV after surgery with a mean follow up of 8.8 years. The NPA pre/postoperative showed a memory decline for these patients related to seizures control and side of surgery (p<0.0001). We found no significant difference between the postoperative NPAs carried out in two different times and separated in groups regarding seizure control and side of surgery; however, all tests indicated a trend towards improvement trend in memory performance and eIQ. We observed a larger hippocampal volume for the controls (mean=3706±842), in comparison with seizure free patients (mean=3602±711) and smaller hippocampal contralateral volumes for patients with persistent seizures after surgery (mean=3284±521). We observed a significant difference (p=0.005) in T2 signal between patients and controls (increase in patients). We also observed changes with a significant difference to the white matter tracts analyzed with diffusion tensor images, in the ipsilateral side of surgery compared to controls. Our results show good seizure control after surgery, even after a long period of follow up. However, our results showed that after surgery there is a decline in the performance on neuropsychological tests for most patients, regardless of the side of surgery. However, the long-term repeated analysis showed that there is partial recovery that may be associated with the interaction between learning effect and brain plasticity. We can hypothesize that the improvement in seizure control after surgery allows "recovery" of the long-term cognitive efficiency
Doutorado
Fisiopatologia Médica
Doutora em Ciências
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7

Dibenedetto, Silvia. "Direct activation of endogenous Calcineurin A : biological impact of selective peptide aptamers." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2011. http://tel.archives-ouvertes.fr/tel-00757018.

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Therapeutic approaches leading to the stimulation of regeneration, and/or inhibition of degeneration processes in neuromuscular disorders are believed to offer valid therapeutic strategies that would preserve muscle tone and contribute to the quality of life while lengthening patient life span. Activation of CalcineurinA (CnA), a threonine-serine phosphatase, controls gene regulatory programs in skeletal muscle by stimulating slow muscle fiber (type I) gene expression. This phosphatase has been also identified as a key mediator in the hypertrophic response and in skeletal muscle regeneration. Activation of CnA is, therefore, considered as a potentially interesting means of stimulating muscle regeneration in myopathies. We have identified a peptide aptamer that activates CnA in vitro, in cells and in vivo. In a mouse model for denervation-induced muscle atrophy, CnA-activating peptide aptamers show significant positive impact. This is reflected in larger overall muscle cross-sectional surface area due to an increased number of fibers and larger individual fiber surface area. Insight into the biological mechanism is afforded by observation of increased levels of nuclear NFAT transcription factor in these fibers, in agreement with peptide aptamer-mediated activation of CnA. Furthermore, a significant increase in central nuclei, characteristic of the presence of new fibers, is observed in muscles treated with the peptide aptamers specifically activating CnA. Identification of the specific binding site of the peptide aptamer on CnA was achieved using several truncations of the phosphatase, offering insight into the molecular mechanism of action. Together, these studies offer the first proof that direct activation of endogenous CnA has a measureable impact on cellular responses resulting in stimulation of muscle regeneration and enhancement of pathophysiological state in selected animal models.
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8

Pinheiro, Clara Maria [UNESP]. "Efeito da inflamação do tornozelo sobre as características histológicas, a expressão gênica e níveis da creatina cinase nos músculos sóleo e tibial anterior de ratos diabéticos." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/87973.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Universidade Estadual Paulista (UNESP)
O Diabetes mellitus é um dos mais importantes problemas de saúde pública, ocasionando complicações crônicas como a atrofia muscular e perda da qualidade de vida do paciente. Quando ocorre uma lesão articular, o músculo responde com um processo de atrofia onde é gerada uma modificação no tecido muscular funcionalmente relacionado com essa articulação. Contudo, estudos experimentais que contribuam ao esclarecimento da relação entre inflamação articular e as modificações histológicas e da expressão gênica do músculo de animais diabéticos não têm sido desenvolvidos. Outro parâmetro importante que deve ser estudado é a atividade da enzima creatina cinase (CK) uma vez que sua atividade pode ser alterada em função de várias causas como na injúria, distrofia, inflamação ou necrose da musculatura esquelética ou cardíaca. O presente projeto teve por objetivo estudar o efeito da inflamação aguda do tornozelo sobre os músculos Sóleo (SO) e Tibial Anterior (TA), investigando a presença de alterações histológicas, alterações na expressão gênica dos atrogenes atrogina-1e MuRF-1 e na atividade da creatina cinase em músculos de ratos não-diabéticos e diabéticos com e sem tratamento insulínico. Foram estudados 54 ratos Wistar (150g). A indução do diabetes foi por via intrapenitoneal com 50mg de estreptozotocina (STZ) por Kg de peso corporal, dissolvida em tampão citrato pH 4,5. Para a inflamação a articulação do tornozelo foi mantida em 90° localizando a fossa distal e posterior ao maléolo lateral, introduzindo nesta zona uma agulha de diâmetro 26 com 0.03ml carragenina a 3%. Os grupos de animais diabéticos com terapia insulínica foram tratados duas vezes ao dia (as 8h e 17h) com 2,5 U de insulina NPH durante 13 dias, totalizando 5U/dia A insulina foi administrada por via subcutânea...
Diabetes mellitus is one of the most serious public health problems, which diminishes the quality of life of the patient and leads to many chronic complications, one of which is muscle atrophy. When a joint is injured, the muscle responds with a process of atrophy in which a change occurs in the muscle tissue functionally related to the joint. However, no experimental studies have been carried out to clarify the relationship between joint inflammation and changes in the histology and gene expression of muscles in diabetic animals. Another important variable that should be studied is the activity of the enzyme creatine kinase (CK), since it can be altered under various conditions, such as injury, muscular dystrophy, inflammation or necrosis of skeletal or heart muscle. The aim of this project was to study the effect of acute inflammation of the ankle on the soleus (SO) and tibialis anterior (TA) muscles, by noting the histological changes, changes in the expression of the atrophy-related genes (atrogenes) atrogin-1 and MuRF-1 and activity of CK in muscles of non-diabetic and diabetic rats, treated and untreated with insulin. We studied 54 Wistar rats (150g). Diabetes was induced by intraperitoneal injection of 50mg streptozotocin (STZ) per kg body weight, dissolved in citrate buffer (pH 4.5). To induce inflammation, the ankle joint was held at 90°, with the fossa located distal and posterior to the lateral malleolus, and inserting a 26-gauge needle into this region, with 0.03mL of 3% carrageenan. The groups of insulin-treated diabetic animals were treated twice a day (at 8 am and 5 pm) by subcutaneous injection with... (Complete abstract click electronic access below)
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9

Moucheront, Nicolas. "Le Palais des doges de Venise à l'époque moderne (1595-1625) : la conclusion d’un grand chantier." Electronic Thesis or Diss., Paris, EHESS, 2024. http://www.theses.fr/2024EHES0014.

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Les formes gothiques du Palais des doges de Venise se mettent en place à partir de 1340 et les travaux se poursuivent sans solution de continuité durant les derniers siècles du Moyen Âge et pendant toute la Renaissance. L’édifice acquiert ses formes actuelles vers 1625 et n’a depuis plus connu que des chantiers de restaurations. Cette thèse en histoire de l’architecture analyse la phase conclusive de ce processus constructif afin de comprendre comment et pourquoi à partir de 1595 ce grand chantier s’achève. Les dynamiques de financement des travaux publics à Venise sont dans un premier temps inscrites dans une perspective de longue durée analysant le rôle de l’Office du sel dans l’amortissement de la dette publique entre le Moyen Âge et l’époque moderne. Cette étude permet de reparcourir à l’aide de la bibliographie disponible les principales étapes de construction du Palais des doges et de reprendre sur le plan financier l’étude de quelques grands chantiers vénitiens de la fin du XVIe siècle tels que la construction du pont du Rialto ou de l’église du Rédempteur. L’analyse du rôle institutionnel de l’Office du sel est dans une seconde partie confrontée à la conjoncture politique que traverse la République de Venise au moment de la crise de l’Interdit. Des recherches biographiques portant sur la commande publique et privée des différents doges qui se succèdent entre 1595 et 1625 sont développées avec un intérêt particulier pour les représentants respectifs des vecchi favorables au pape et de leurs antagonistes, les giovani, Marino Grimani et Leonardo Donà. Des recherches dans des archives de la République et de la famille ont également été accordées au parcours exceptionnel d’Antonio Priuli entre Padoue et Paris. Il conduit en effet tant que Réviseur de tous les lieux de la cour du Palais des doges de 1601 à 1614 les transformations de l’édifice puis relance les travaux lorsqu’il monte sur le trône ducal entre 1618 et sa mort en 1624. Pendant toute cette période, le charpentier Bartolomeo Manopola dirige le chantier en tant que proto de l’Office du sel. Une analyse détaillée est accordée à l’organisation de son entreprise familiale de construction associant tailleurs de pierres, charpentiers et maçons. Les relations entre la fabrique publique et des personnages de premier plan tels que le tailleur de pierre Giovanni Grapiglia, l’architecte Vincenzo Scamozzi ou le marchand d’art Daniel Nijs sont également développées en croisant une analyse des réseaux des commanditaires, des détails de l’architecture et de la comptabilité du chantier. Cette micro-histoire de l’infrastructure productive du chantier sert de support à une analyse de la suprastructure, c’est-à-dire des transformations architecturales que connaît le Palais des doges entre 1595 et 1625.Après avoir interprété à la lumière des rapports de force internes au chantier le programme fonctionnel qui se définit progressivement pour les salles réaménagées au rez-de-chaussée de l’édifice et dans les loges, les représentations du pouvoir sur la façade dite de l’horloge et dans la nouvelle salles des banquets sont analysées en regard de la situation politique qui se dégrade avec la guerre de Gradisca et devient explosive au moment de l’avènement d’Antonio Priuli en 1618 avec la conjuration Bedmar. Un chapitre d’ouverture replaçant le processus de modernisation du Palais des doges dans les cycles de transformation que connaissent à la même époque les autres sièges du pouvoir vénitien dans les villes du Stato da Terra et da Mar permet enfin de saisir la fonction politique qu’assume projet d’architecture dans une République. Le palais public sont des représentations du pouvoir sophistiquées dont les processus de transformations matérielles servent de support à de complexes négociations permettant de dépasser des moments de crises politiques
The gothic Venice Ducal Palace was realized for 1340 but all the last centuries of Middle Ages long and for whole Renaissance, works have gone ahead seamless. Around 1625, the building reach its actual design and till this moment, only restoration works have been realized. This PhD tesis in architecture history studies the conclusive moment of this building process in order to understand why and how for 1595 so big a building site achieves. Financing dynamics of public works in Venice are first of all inserted within a long term analysis from the amortization of public debt between Middle Ages and Modern times. Such a study consent to pass in review thanks to available publications the main steps of the Ducal Palace building and to advocate a financial study of some of the major public buildings in Venice late XVIth century such as Rialto bridge or Redentore church.This study on the institutional functions of the Salt Office is in a second moment addressed to a specific political moment for the Venice Republic, the Interdetto crisis. A series of biographic researches about public and private commissions of several doges on power from 1595 to 1625 is developed, focusing on the respective leaders from the pro papalist vecchi and their opponents, the giovani patricians, Marino Grimani and Leonardo Donà. Specific research on public records and family archives are also dedicated to the exceptional journey from Padua to Paris of Antonio Priuli. Indeed, as Surveyor from all the Ducal palace places, he is responsible for the transformation of this building between 1601 and 1614. Then, he relaunches the works when arriving on power from 1618 till his death in 1624. During all this time long, the carpenter Bartolomeo Manopola conducts the works as Salt office proto. A detailed study is realized on his family building firm associating stone carvers, carpenters and masons. The relationships between public building and important figures from the time such as the stone carver Giovanni Grapiglia, the architect Vincenzo Scamozzi and the art seller Daniel Nijs are also developed associating a study on the commissioners network, architecture details and building site accounts. Such a micro-historic approach from the productive structure of the building site is the base for an analysis from the superstructure, ie for a survey on the Ducal palace architecture transformations from 1595 to 1625.Internal conflicts enable an interpretation of the functional program for the room gradually arranged on the ground floor on the building and inside the lodges. The powers representations shaped on on the clock facade and inside the new banqueting room are then analyzed through a political length, considering the difficult situation resulting from the Gradisca war and the hot moment of the Bedmar plot in 1618, just when Antonio Priuli finally became doge. An opening chapter concludes the tesis putting the Ducal palace transformations within the current transformation cycles of the other headquarters of the Venitian power in Main Land and Sea Land main towns. The aim is to catch the political function from architecture design process in a Republic. Public palaces are sophisticated representations from power. Theirs material transformations are as a consequence the tools from complex negotiations in grade of overall political crisis moments
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Maessen-Visch, Marjolein Birgitte. "Atrophie blanche." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6721.

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Книги з теми "Atropie"

1

Tatakē, Despoina Lelekou. Atropos. [Greece]: Smyrniōtakēs, 1994.

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Xiao, Junjie, ed. Muscle Atrophy. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1435-3.

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Di Girolamo, Stefano, ed. Atrophic Rhinitis. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2.

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Piracha, Kashif. Chronic Atrophic Gastritis. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-09872-7.

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Wenning, Gregor K., and Alessandra Fanciulli, eds. Multiple System Atrophy. Vienna: Springer Vienna, 2014. http://dx.doi.org/10.1007/978-3-7091-0687-7.

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National Institutes of Health (U.S.). Multiple system atrophy. Bethesda, Md: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 2009.

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National Institutes of Health (U.S.). Multiple system atrophy. Bethesda, Maryland: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 2012.

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Dimiters, Kaspars. Atrodi mani. Rīgā: Avots, 1998.

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Ligtenstein, David Awraham. On the synergism of the cholinesterase reactivating bispyridinium-aldoxime HI-6 and atropine in the treatment of organophosphate intoxications in the rat. The Netherlands: Kanters b.v., Albasserdam, 1985.

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Gopal, Guru, ed. Atrophy in dalit politics. Mumbai: Vikas Adhyayan Kendra, 2005.

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Частини книг з теми "Atropie"

1

Bährle-Rapp, Marina. "Atrophie, auch: Atrophia." In Springer Lexikon Kosmetik und Körperpflege, 51. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_879.

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French, Robert N. E., and Frank G. Walter. "Atropine." In Critical Care Toxicology, 1–7. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20790-2_153-1.

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French, Robert N. E., and Frank G. Walter. "Atropine." In Critical Care Toxicology, 2725–31. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-17900-1_153.

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Fang, Lian-Hua, Jin-Hua Wang, and Guan-Hua Du. "Atropine." In Natural Small Molecule Drugs from Plants, 181–86. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8022-7_29.

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Jain, Tushar, Himanshu Kumar Sanju, Mariapia Guerrieri, Massimo Ralli, and Roberta Di Mauro. "Primary Atrophic Rhinitis: Ozaena and Other Infective Forms." In Atrophic Rhinitis, 3–9. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2_1.

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Sarafoleanu, Codrut, and Elena Patrascu. "Atrophic Rhinitis: Medical Treatment." In Atrophic Rhinitis, 109–15. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2_10.

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Di Girolamo, Stefano, Mariapia Guerrieri, Barbara Flora, and Francesco Maria Passali. "Surgical Treatment of Empty Nose Syndrome: Inferior Turbinate Reconstruction Using Intranasal Mucosal Flaps." In Atrophic Rhinitis, 117–25. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2_11.

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Cervelli, Valerio, and Gabriele Storti. "Surgical Treatment of Atrophic Rhinitis: Inferior Turbinate Augmentation with Submucosal Injections." In Atrophic Rhinitis, 127–40. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2_12.

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Mocella, Stelio Antonio, Riccardo Nocini, Valentina Rosati, Giorgio Giacomini, and Pier Giorgio Giacomini. "Nasal Septal Perforations: Modern Diagnostic Work-Up, Management and Surgical Strategy." In Atrophic Rhinitis, 141–58. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2_13.

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Schiavon, Patrizia, Rosa Maria Minniti, Maria Chiara Cimatti, and Matteo Campa. "Surgical Treatment of Atrophic Rhinitis: The Use of Autografts in Nasal Dorsum Repair." In Atrophic Rhinitis, 159–81. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51705-2_14.

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Тези доповідей конференцій з теми "Atropie"

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Souza, Thierry Kaue Alves Silva, Nara Maria Borges Alves, Fabiana Moraes, Felipe de Paula, Luciana Yasuda Suemitsu, Paula Azevedo, Luiza Piovesana, et al. "Cortical and subcortical atrophy in individuals with Huntington's disease and Huntington-like disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.551.

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Background: Huntington-like (HL) syndrome represents a group of diseases clinically similar to Huntington disease (HD) with different genetic etiology. Here, we aimed to compare clinical and neuroimaging features between HL and HD. Methods: We assessed 12 patients with HL (6 men; 53.66±13.02 years old) and 12 with HD (genetically confirmed, 6 men; 52.58±11.64 years old). All patients were followed at UNICAMP and were matched to sex, age, age at onset and duration of disease. They underwent 3T MRI scans, detailed neurological examination, the unified Huntington’s disease rating scale (UHDRS), the Montreal cognitive assessment (MOCA), Beck depression inventory (BDI), and the scale for the evaluation of rating ataxia (SARA). We APPLIED voxel-based morphometry technique (SPM12/CAT12/MATLAB software) to assess differences in the gray and white matters between groups and matched controls. Results: Groups were clinically similar, but the VBM study revealed widespread cortical (bilateral) and subcortical atrophy in HD (bilateral globi pallidi, amygdala, hippocampi, caudate and putamen), with a more restricted cortical (left temporal lobe) subcortical atrophy in HL (bilateral thalami, putamen and left hippocampus). Cortical atrophy in HL concentrated in the bilateral putamen. The left hippocampus were atrophic in both groups. Conclusion: Despite similar clinical presentation, patients with HL and HD have distinctive patterns of atrophy subcortical structures, mainly in the thalami. These results may raise insights into the underlying disease mechanisms in HL and HD and could be useful as biomarkers of disease progression in future therapy trials.
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Petrovic, Aleksandra, Gorica Vukovic, Tijana Stojanovic, Dušan Marinkovic, Bojan Konstantinovic, Bojana Špirovic-Trifunovic, Željka Jeličic Marinkovic, and Vojislava Bursic. "OCCURRENCE OF TROPANE ALKALOIDS IN MAIZE DUE TO THE PRESENCE OF SOLANACEAE FAMILY." In XXVI savetovanje o biotehnologiji sa međunarodnim učešćem. University of Kragujevac, Faculty of Agronomy, 2021. http://dx.doi.org/10.46793/sbt26.297p.

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Tropane alkaloids are considered to be serious health hazard for humans and that their maximum residue levels in food and feed are still not established. In this paper five samples of maize collected from the local producer in 2020 have been investigated by the liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the atropine and scopolamine determination. The detected concentrations of atropine and scopolamine were extremely high (17.7-67.0 μg/kg for atropine and 2.3-10.4 μg/kg for scopolamine). The obtained results show the seriousness of the tropane alkaloids problem in maize as well as the need for monitoring and further research.
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Ahmad, Anita, Fernando S. Schlindwein, Jiun H. Tuan, and G. Andre Ng. "Isoprenaline and Atropine Effect on Atrial Arrhythmias Study." In ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2010. http://dx.doi.org/10.1115/esda2010-25416.

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Atrial Fibrillation (AF) is the most common disorder of the heart rhythms. There are about 2.3 million people in United States and 4.5 million people in the European Union with AF [Go et.al, 2001]. It is also one of the factors that may contribute to mortality and morbidity. Researchers who apply spectral techniques show that certain areas of the atria can have higher activation frequencies than other areas. Frequency analysis is used to measure changes in Dominant Frequency (DF). We access the electrical propagation inside the atria by spectrogram plotting and examining the effect of isoprenaline and atropine on frequency changes.
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Caspers, J., B. Turowski, and C. Rubbert. "Automatisierter Workflow zur altersabhängigen Abschätzung regionaler Hirn-Atrophie." In 100. Deutscher Röntgenkongress. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0037-1682164.

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Fray, Georgina. "6183 Behavioural side effects of atropine eye drops." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference, Birmingham, 25 March 2024 – 27 March 2024. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2024. http://dx.doi.org/10.1136/archdischild-2024-rcpch.597.

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Baskaya, O., M. Kandemir, M. S. Tepe, M. Acar, G. Unal, Z. B. Yalciner, and D. Unay. "Inter-hemispheric atrophy better correlates with expert ratings than hemispheric cortical atrophy." In 2012 20th Signal Processing and Communications Applications Conference (SIU). IEEE, 2012. http://dx.doi.org/10.1109/siu.2012.6204783.

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Bin Zahid, Abdullah, Artem Mikheev, Andrew Il Yang, Uzma Samadani, and Henry Rusinek. "Calculation of brain atrophy using computed tomography and a new atrophy measurement tool." In SPIE Medical Imaging, edited by Sébastien Ourselin and Martin A. Styner. SPIE, 2015. http://dx.doi.org/10.1117/12.2080860.

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Arnold, D., J. Thielker, M. Geitner, C. Klingner, WC Puls, W. Misikire, V. Mastryukova, M. Heinrich, O. Guntinas-Lichius, and GF Volk. "Elektrische Oberflächenstimulation zur Vermeidung von Atrophie in denervierten Gesichtsmuskeln." In 100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN? Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1728892.

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Manso, Silvia De Miguel, Rocío Gutiérrez Bustillo, Carlota Gordaliza Pastor, and Pilar Olmedo Olmedo. "#35955 Inadverted intrathecal injection of atropine and anaphylactic shock." In ESRA Abstracts, 40th Annual ESRA Congress, 6–9 September 2023. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/rapm-2023-esra.396.

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Luke-Zeitoun, Mona, Ben Wildman-Tobriner, Emily Ghio, Anthony Luke, Nicolas Hatamiya, Dennis Nielson, Warren Gold, and Stephen Lazarus. "Atropine Blocks Post-Exercise Airway Obstruction In Asthmatic Elite Swimmers." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2406.

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Звіти організацій з теми "Atropie"

1

Taylor, Henry L., John A. Dellinger, Bruce C. Richardson, Martha H. Weller, and Stephen W. Porges. The Effects of Atropine Sulfate on Aviator Performance. Fort Belvoir, VA: Defense Technical Information Center, March 1985. http://dx.doi.org/10.21236/ada179078.

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Tornell, Aaron. Rational Atrophy: The US Steel Industry. Cambridge, MA: National Bureau of Economic Research, July 1997. http://dx.doi.org/10.3386/w6084.

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Isaacs, Jonathan E. Anabolic Steroid Reversal of Denervation Atrophy. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada562447.

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Harlan, Michael J. Force Projection Logistics Atrophy: Affliction and Treatment. Fort Belvoir, VA: Defense Technical Information Center, March 2011. http://dx.doi.org/10.21236/ada547429.

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Chau, Mi. Effect of Gender on Spinal Muscular Atrophy. Ames (Iowa): Iowa State University, May 2023. http://dx.doi.org/10.31274/cc-20240624-582.

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Tsai, Hou-Ren, Tai-Li Chen, Jen-Hung Wang, Huei-Kai Huang, and Cheng-Jen Chiu. Efficacy and safety of 0.01% atropine in childhood myopia: A meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0082.

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Jacobi, Kevin L. The Atrophy of Land Power: A Strategic Risk? Fort Belvoir, VA: Defense Technical Information Center, March 2013. http://dx.doi.org/10.21236/ada589526.

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Allotey, Saida Akushika. Treatment of Spinal Muscular Atrophy using Gene therapy. Ames (Iowa): Iowa State University, May 2023. http://dx.doi.org/10.31274/cc-20240624-1524.

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Shults, Clifford W. Alpha Synuclein in a Model of Multiple System Atrophy. Fort Belvoir, VA: Defense Technical Information Center, September 2003. http://dx.doi.org/10.21236/ada419316.

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Chen, Chuyan, Yi Yang, Peng Li, and Haiyi Hu. Incidence of gastric neoplasms arising from autoimmune metaplastic atrophic gastritis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0021.

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