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Статті в журналах з теми "Astature"
Li, Yawen, Ming-Kuan Chyan, Donald K. Hamlin, Holly Nguyen, Eva Corey, and D. Scott Wilbur. "Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo." International Journal of Molecular Sciences 23, no. 18 (September 13, 2022): 10655. http://dx.doi.org/10.3390/ijms231810655.
Повний текст джерелаNagao, Y., M. Yamaguchi, S. Watanabe, N. S. Ishioka, N. Kawachi, and H. Watabe. "Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows." Journal of Instrumentation 16, no. 12 (December 1, 2021): C12031. http://dx.doi.org/10.1088/1748-0221/16/12/c12031.
Повний текст джерелаWilbur, D. "[211At]Astatine-Labeled Compound Stability: Issues with Released [211At]Astatide and Development of Labeling Reagents to Increase Stability." Current Radiopharmaceuticalse 1, no. 3 (September 1, 2008): 144–76. http://dx.doi.org/10.2174/1874471010801030144.
Повний текст джерелаCORSON, DALE R. "ASTATINE." Chemical & Engineering News 81, no. 36 (September 8, 2003): 158. http://dx.doi.org/10.1021/cen-v081n036.p158.
Повний текст джерелаMeyer, Geerd-J. "Astatine." Journal of Labelled Compounds and Radiopharmaceuticals 61, no. 3 (February 22, 2018): 154–64. http://dx.doi.org/10.1002/jlcr.3573.
Повний текст джерелаWilbur, D. Scott. "Enigmatic astatine." Nature Chemistry 5, no. 3 (February 20, 2013): 246. http://dx.doi.org/10.1038/nchem.1580.
Повний текст джерелаSarr, Serigne, Julien Pilmé, Gilles Montavon, Jean-Yves Le Questel, and Nicolas Galland. "Astatine Facing Janus: Halogen Bonding vs. Charge-Shift Bonding." Molecules 26, no. 15 (July 28, 2021): 4568. http://dx.doi.org/10.3390/molecules26154568.
Повний текст джерелаYagishita, Atsushi, Miho Katsuragawa, Shin’ichiro Takeda, Yoshifumi Shirakami, Kazuhiro Ooe, Atsushi Toyoshima, Tadayuki Takahashi, and Tadashi Watabe. "Development and Utility of an Imaging System for Internal Dosimetry of Astatine-211 in Mice." Bioengineering 11, no. 1 (December 26, 2023): 25. http://dx.doi.org/10.3390/bioengineering11010025.
Повний текст джерелаDzhuzha, D., and S. Myasoyedov. "Radionuclide therapy with alpha-emitters." Radiation Diagnostics, Radiation Therapy, no. 4 (2019): 37–47. http://dx.doi.org/10.37336/2707-0700-2019-4-4.
Повний текст джерелаNemec, S. "Glomus intraradix effects on citrus rootstock seedling growth in various potting media." Journal of Agricultural Science 118, no. 3 (June 1992): 315–23. http://dx.doi.org/10.1017/s0021859600070684.
Повний текст джерелаДисертації з теми "Astature"
Desiree, Patrick R. "Synthèse et développement de macrocycles pour la capture d'anions d'intérêt thérapeutique." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0152.
Повний текст джерелаSupramolecular chemistry consists of molecular architecture complex organized thanks to a combination of non-covalent interactions. At the natural state, these structures have numerous functions such as cell energy production thanks to the ATP synthase or the genetic support thanks to a polyanion, the DNA molecule. Anions can be involved in radiotherapy through iodide. By opposition, it can also be associated with environmental disasters (Fukushima explosion in 2011) or some diseases (thyroid disease). In front of these troubles, it is a priority to fight against theses disastrous events. This PhD work has focused on the construction of boronium type macrocycle able to strongly trap iodide which is an anion model to study astatide trapping. This coordination is done thanks to hydrogen bonding and ionic interactions collaboration. Based on previous works realized in our laboratory in 2010, complexation properties of Calix-carBIB were studied. In a second time, new functionalized groups were used to study their potential for different applications such as astatide purification, water solubility and vectorization. Finally, a new receptor generation was studied, showing a better affinity for astatide
Liu, Lu. "Exploration de la chimie de l'astate en solution : focalisation sur le diagramme de Pourbaix en milieu non complexant et caractérisation de liaisons halogènes induites par l'astate." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2020. http://www.theses.fr/2020IMTA0205.
Повний текст джерелаAstatine (At, Z = 85) is a scarce halogen element, all of its isotopes being radioactive. Due to the limited available quantities, no spectroscopic tool is applicable to identify the molecular nature of At species. Consequently, the chemistry of At remains poorly known. One of its isotopes, ²¹¹At, is a potential candidate for the treatment of cancers by targeted alpha therapy. However, the limited knowledge of its chemical properties has hindered attempts to label ²¹¹At with disease targeting carrier molecules. This led to the development of a research program on the basic chemistry of At. This thesis focuses more particularly on the Pourbaix diagram of astatine and the characterization of halogen bonds with the AtI species, by means of various experimental tools (ion chromatography, competition method and electromobility). In the first part, speciation studies of At in alkaline medium confirm the presence of the At⁻ species under reducing conditions. As the potential increases, the AtO(OH)₂⁻ species is formed. The speciation change between these two species is described for the first time. In a second part, the formation of halogen bonds between the AtI species and various organic compounds was studied. The reactivity is summarized by a newly established basicity scale, with the strength between the donor (AtI) and the acceptor atom following the order of C≤ O ≤ S (≈ Se)
Da, Silva I., T. Sauvage, P. Rifard, F. Durand, J. P. Trasbot, and N. Michel. "Evolution of production of Astatine-211 in Orléans Cyclotron." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166243.
Повний текст джерелаChampion, Julie. "Exploration du caractère métallique de l'astate en solution aqueuse." Nantes, 2009. http://www.theses.fr/2009NANT2086.
Повний текст джерелаAlpha-radiotherapy is an innovative technique for the treatment of cancers complementary to current approaches. The principle is to use tumor-specific vectors labeled with alpha-radioisotopes. Astatine 211 is a very promising candidate if one considers the energy of the particles emitted as well as its physical half-life (7. 2 h). One of the ways of labeling is to use astatine at a higher oxidation state as a « metal cation ». Indeed, considering its location in the periodic table, astatine is supposed to present a more metallic character than the other halogens. This way of labeling has however never been explored. This can be explained by the fact that the astatine chemistry is nearly unknown. The purpose of this work was therefore to explore this property of astatine and to define its Eh, pH diagram (or Pourbaix diagram) in non complexing aqueous solution. To this end, both experimental and theoretical approaches were used. The experimental approach uses competition methods to identify the formed species and the thermodynamics constants of studied equilibria. The theoretical approach uses methods of computational chemistry and provides information at the molecular scale on the studied systems in order to predict thermodynamic data which are used as support and complement to the experimental approach. The important result of this work shows the presence of two stable cationic forms of astatine in aqueous solution, i. E;, At+ and AtO+
Guo, Ning. "Investigation of the chemical properties of astatine at +I and –I oxydation states in aqueous solution." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT4038/document.
Повний текст джерелаTargeted alpha therapy is an appealing method for the treatment of cancer as a complement to the current approaches. Astatine-211, with a half-life of 7.21 h, is considered as an exciting prospective candidate for this application. A pre-required condition is to fix in a stable way the radioactive isotope to the vector that is going to serve to recognize cells. This asks for a thorough knowledge of the chemical properties of astatine. Considering its position in the periodic table, it can exist under the form At− in coherence with the chemical properties of the other halogens, and also possesses a more metallic character that explains the existence of stable cationic species. The objective in this work is to identify the properties of different At species in aqueous solution. The predominance of the species At− in reducing acidic conditions was confirmed by means of a technique of electromobility. A first value of absolute mobility is then proposed. In more oxidizing conditions, the species At+ dominates. The reactivity of this species with the ions of the halogens series was studied/quantified. An exotic species IAtBr− was highlighted in particular thanks to the help of modeling tools. The peculiarity of the compound AtI to form halogen-type bonds was shown for the first time
Guérard, François. "Nouvelle méthode de radiomarquage des anticorps à l'astate-211 hypervalent pour la radioimmunothérapie alpha des cancers." Nantes, 2010. https://archive.bu.univ-nantes.fr/pollux/show/show?id=55d1b24d-6cbb-4198-af40-b3764c525301.
Повний текст джерелаAstatine-211 is a promising alpha emitter for the therapy of cancers. In association with a suited immunologic carrier, it could allow the treatment of some micrometastasis or residual cancer diseases. However, the lack of stability of the radiolabelling of the antibodies with this radionuclide is a limitation for the development of clinical applications. This work describes a new approach for the radiolabelling of the antibodies with astatine-211. The specificity of this method is the use for the first time of hypervalent astatine. Tin precursors were designed to allow the introduction of astatine-211 under a stabilised trivalent state. The feasibility study of the radiolabelling of the antibodies with this method and the preliminary stability assesments are also described
Lindegren, Sture. "Astatine-211 and iodine conjugates : radiohalogenation and preclinical pharmacokonetics for targeted and pretargeted radioimmunotherapy /." Göteborg : Chalmers Univ. of Technology, 2002. http://www.gbv.de/dms/bs/toc/348722176.pdf.
Повний текст джерелаSergentu, Dumitru-Claudiu. "Géométries, electronic structures, and physico-chemical porperties of astatine species : an application of relativistic quantum mechanics." Thesis, Nantes, 2016. http://www.theses.fr/2016NANT4024/document.
Повний текст джерелаTrials to destroy cancer cells with currently synthesized 211 At-based radiotherapeutic agents are not yet fully satisfactorily since they resume to in vivo deastatination. Since this issue is related to the limited knowledge of the basic chemistry of At and its species, fundamental researches combining ultra-trace experiments and computational studies have been initiated. In this thesis, a computational study of several At species is performed, by means of relativistic density functional theory and wave-function-based calculations. First, the quantum mechanical approaches that can safely be used to make adequate predictions are established. Using these approaches, we attempt to rationalize the electronic structures, geometries, and physico-chemical properties of various systems of theoretical and/or experimental interest, in particular the AtF3 and AtO+ ones. By the end, we firmly identify a new At species by combining outcomes of experiments and calculations. This new species not only completes the Pourbaix diagram of At in aqueous and non-complexing media, but also gives clues of identifying experimental conditions to make best reactive the At– precursor, which is currently involved in the synthesis of promising radiotherapeutic agents
Bourgeois, Mickaël. "Étude de faisabilité de Radio-Immunothérapie alpha à l'astate-211." Nantes, 2009. https://archive.bu.univ-nantes.fr/pollux/show/show?id=451eb856-6a13-4712-9592-273f054a9531.
Повний текст джерелаAlpha radio-immunotherapy is a promising cancer therapy that uses alpha-particles vectorized by monoclonal antibody to break down cancerous tumours. The first part of this work presents the different factors that affect the success of radio-immunotherapy in cancer treatment. Specifically we concentrate on astatine-211, an α particle emitting isotope that has shown great promise for cancer treatment. The differents studies of the immuno-vectorisation of this isotope are also presented in this section. The second part of this thesis aims to evaluate the feasibility of immunoglobulin labelling (full or F(ab')2 fragment) with astatine-211. The labelling took place using a cyclotron irradiation to produce astatine-211 which was subsequently extracted by treating the target with nitric acid. This experimental study allowed us to optimize the labelling process to an in vivo stable immunoglobin labelled with astatine-211 such that a pre-clinical study is plausible
Berdal, Marion. "Exploration de nouvelles voies de radiomarquage avec l’astate-211 sous forme nucléophile : application à la préparation de radioimmunoconjugués pour la thérapie alpha vectorisée des cancers." Thesis, Nantes, 2020. http://www.theses.fr/2020NANT1021.
Повний текст джерелаAstatine-211 is a promising radionuclide for targeted alpha therapy of cancers. However, current approaches to bind this radiohalogen to an antibody exhibit limitations such as suboptimal radiochemical yields or the use of toxic precursors, which complicates its clinical transfer. In order to find better alternatives, we explored new classes of precursors, which allow the radiolabelling with astatine-211 and iodine-125 in their nucleophilic form. First, the synthesis of model compounds for each class and the comparison of their efficiency were performed to identify the most promising ones for the radiolabelling with both radionuclides. In a second part, the feasibility of the one-step radiolabelling of antibodies with astatine-211 and iodine-125 using arylboronic acids has been investigated. First, the study on a model compound was conducted in order to identify efficient conditions in aqueous medium and at low temperature before transfering this approach to an anti-CD138 antibody of interest for targeting multiple myeloma. The new process developped outperforms others methods reported in the litterature and has been validated in preclinical biodistribution studies. This new radiolabelling method will ease the clinical transfer of astatine-211 as well as the development of theranostic tools based on the astatine/iodine pair
Книги з теми "Astature"
Berei, Klara, Siegfried H. Eberle, H. W. Kirby, Helmut Münzel, Kurt Rössler, Arnulf Seidel, and László Vasáros. At Astatine. Edited by Hans Karl Kugler and Cornelius Keller. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8.
Повний текст джерелаSims, H. E. ²¹¹At and ⁹⁰Y: Two nuclides for potential use in tumour therapy : production at Harwell Laboratory. Oxfordshire: Chemistry Division, Harwell Laboratory, 1986.
Знайти повний текст джерелаKenyon, Michael. Astatine. Brick Books Incorporated, 2014.
Знайти повний текст джерелаKeller, Cornelius, and Hans K. Kugler. At Astatine. Springer, 2013.
Знайти повний текст джерелаRoza, Greg. Halogen Elements Fluorine, Chlorine, Bromine, Iodine, Astatine. Rosen Publishing Group, 2010.
Знайти повний текст джерелаZegeye, Abebe. Mulatu Astatke: The Making of Ethio Jazz. Africa World Press, 2022.
Знайти повний текст джерелаDeCarlo, Raymond A. Linear systems: Astate variable approach with numerical implementation. Prentice-Hall International, 1989.
Знайти повний текст джерела(Firm), Universal Map. Lake County, Florida, StreetMap: Including Astatula, Clermont, Eustis ... Umatilla & neighboring communities. UniversalMAP, 1999.
Знайти повний текст джерела(Firm), Universal Map. Lake County, Florida, StreetMap: Including Astatula, Clermont, Eustis ... Umatilla & neighboring communities. UniversalMAP, 2000.
Знайти повний текст джерелаAstatula Flor State of Mind Collection. Sudoku Genius Mind Exercises Volume 1: Astatula, Florida State of Mind Collection. Independently Published, 2019.
Знайти повний текст джерелаЧастини книг з теми "Astature"
Kirby, H. W. "History." In At Astatine, 1–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_1.
Повний текст джерелаEberle, S. H., Klara Berei, and László Vasáros. "Chemical Behavior and Compounds of Astatine." In At Astatine, 183–289. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_10.
Повний текст джерелаKirby, H. W. "Natural Occurrence." In At Astatine, 10–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_2.
Повний текст джерелаMünzel, H. "Nuclear Properties of Astatine Isotopes." In At Astatine, 15–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_3.
Повний текст джерелаKirby, H. W., and K. Rössler. "Production, Isolation, and Purification of Astatine Isotopes." In At Astatine, 95–106. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_4.
Повний текст джерелаVasáros, László, and Klara Berei. "General Properties of Astatine." In At Astatine, 107–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_5.
Повний текст джерелаKirby, H. W. "Analytical Chemistry of Astatine." In At Astatine, 129–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_6.
Повний текст джерелаRössler, K. "Handling of Astatine." In At Astatine, 140–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_7.
Повний текст джерелаSeidel, Arnulf. "Astatine in Biology and Nuclear Medicine." In At Astatine, 157–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_8.
Повний текст джерелаRössler, Kurt. "Irradiation and Self-Irradiation of Astatine Compounds." In At Astatine, 179–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-05868-8_9.
Повний текст джерелаТези доповідей конференцій з теми "Astature"
Jakobsson, U., J. Uusitalo, K. Auranen, H. Badran, B. Cederwall, D. M. Cox, T. Grahn, et al. "Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei." In Nuclear Structure and Dynamics ’15. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4932258.
Повний текст джерелаTakashima, Hiroki, Yoshikatsu Koga, Kazunobu Onuki, Shino Manabe, Ryo Tsumura, Takahiro Anzai, Nozomi Iwata, et al. "Abstract 2863: Preclinical evaluation of astatine-211-conjugated anti-tissue factor antibody." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2863.
Повний текст джерелаUusitalo, J., U. Jakobsson, and Bertram Blank. "Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line." In THE 4TH INTERNATIONAL CONFERENCE ON PROTON EMITTING NUCLEI AND RELATED TOPICS. AIP, 2011. http://dx.doi.org/10.1063/1.3664144.
Повний текст джерелаTakai, Toshihide, Tomohiro Furukawa, Shigeki Watanabe, and Noriko S. Ishioka. "Corrosion Behavior of Iron-Chrome Alloys in Liquid Bismuth." In 2021 28th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icone28-63277.
Повний текст джерелаЗвіти організацій з теми "Astature"
Ruth, T. J., M. Dombsky, J. M. D'Auria, and T. E. Ward. Radiochemistry of astatine. Office of Scientific and Technical Information (OSTI), January 1988. http://dx.doi.org/10.2172/6748269.
Повний текст джерелаWilbur, Daniel. Automated Isolation of Astatine-211 and Chemistry Evaluation. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1651207.
Повний текст джерелаMach, Robert, Hsiaoju Lee, Mehran Makvandi, Sean Reilly, Ho Sze Chan, Paul Martorano, and David Schaub. Production of Astatine-211 for Translational Science in Radiotherapy. Office of Scientific and Technical Information (OSTI), March 2024. http://dx.doi.org/10.2172/2329303.
Повний текст джерелаWilbur, D. S. Pretargeting of Astatine-211 for Therapy of Metastic Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada374830.
Повний текст джерелаLapi, Suzanne E. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1575920.
Повний текст джерелаEllison, Paul, Jonathan Engle, Aeli Olson, Todd Barnhart, Robert Nickles, Sabrina Hoffman, Dhanabalan Murali, Onofre DeJesus, and Bryan Bednarz. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), January 2020. http://dx.doi.org/10.2172/1682261.
Повний текст джерелаMach, Robert. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1839290.
Повний текст джерелаWilbur, Daniel Scott. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators". Office of Scientific and Technical Information (OSTI), December 2012. http://dx.doi.org/10.2172/1124492.
Повний текст джерелаMICHAEL R. ZALUTSKY. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS. Office of Scientific and Technical Information (OSTI), August 2012. http://dx.doi.org/10.2172/1047758.
Повний текст джерелаZalutsky, Michael. Production of Astatine-211 at the Duke University Medical Center for its regional distribution. Office of Scientific and Technical Information (OSTI), January 2016. http://dx.doi.org/10.2172/1233560.
Повний текст джерела