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Статті в журналах з теми "App dependency"
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Barry, D. B., and O. Delatycki. "The strain rate dependency of fracture in polyethylene: Fracture initiation." Journal of Applied Polymer Science 38, no. 2 (July 20, 1989): 339–50. http://dx.doi.org/10.1002/app.1989.070380215.
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Zhao, Xueyan, and Jürgen Pionteck. "Electrochemical performance of polydopamine modified PANI / rGO composites: Dependency on preparation sequence." Journal of Applied Polymer Science 138, no. 28 (March 7, 2021): 50663. http://dx.doi.org/10.1002/app.50663.
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Yang, Xiao, Cristina Tuinea‐Bobe, Ben Whiteside, Phil Coates, Ying Lu та Yongfeng Men. "Molecular weight dependency of β phase formation in injection‐molded isotactic polypropylene". Journal of Applied Polymer Science 137, № 15 (8 жовтня 2019): 48555. http://dx.doi.org/10.1002/app.48555.
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Huang, Jan-Chan. "Probe dependency of segmental interaction parameters in copolymers by inverse gas chromatography." Journal of Applied Polymer Science 119, no. 2 (July 27, 2010): 719–25. http://dx.doi.org/10.1002/app.32739.
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Fukuhara, Mikio. "Temperature dependency of elastic moduli and internal dilational and shear frictions of polyetherimide." Journal of Applied Polymer Science 90, no. 3 (August 18, 2003): 759–64. http://dx.doi.org/10.1002/app.12717.
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Huang, Jan-Chan, and Rudolph D. Deanin. "Concentration dependency of interaction parameter between PVC and plasticizers using inverse gas chromatography." Journal of Applied Polymer Science 91, no. 1 (2003): 146–56. http://dx.doi.org/10.1002/app.13111.
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Itakura, Masanao, Keisuke Sato, Marina A. Lusenkova, Shigetomo Matsuyama, Kayori Shimada, Takeshi Saito, and Shinichi Kinugasa. "Molecular weight dependency of refractive index increment of polystyrene determined by uniform oligomers." Journal of Applied Polymer Science 94, no. 3 (2004): 1101–6. http://dx.doi.org/10.1002/app.21006.
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Maher, Andrew E., Catherine M. Ambler, Eric S. Powell, and Harry R. Allcock. "Dependency of thermal and mechanical properties on the composition of mixed-substituent poly(fluoroalkoxyphosphazenes)." Journal of Applied Polymer Science 92, no. 4 (2004): 2569–76. http://dx.doi.org/10.1002/app.20223.
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Araki, Wakako, Daisuke Asahi, Tadaharu Adachi, and Akihiko Yamaji. "Time-temperature dependency of mode II fracture toughness for bisphenol A type epoxy resin." Journal of Applied Polymer Science 96, no. 1 (2005): 51–55. http://dx.doi.org/10.1002/app.21358.
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Huang, Jan-Chan. "Probe dependency of polymer-plasticizer and polymer-polymer interaction parameters in inverse gas chromatography." Journal of Applied Polymer Science 106, no. 6 (December 15, 2007): 4110–16. http://dx.doi.org/10.1002/app.26953.
Повний текст джерелаДисертації з теми "App dependency"
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Ryczer-Dumas, Malgorzata. "Users’ agencies : juxtaposing public portrayals and users’ accounts of app-mediated cardiac arrest volunteer work in Sweden." Thesis, Paris, EHESS, 2022. http://www.theses.fr/2022EHES0024.
Повний текст джерелаАнотація:
Cette thèse adopte une perspective de recherche en sciences sociales pour examiner les usages de l'application SMSlivräddare (eng. SMSlifesaving), devenue Heartrunner, ayant pour objectif de solliciter des bénévoles à proximité de personnes presumées victimes d'un arrêt cardiaque extra-hospitalier. Cette étude de cas sur les usages de cette application médicale et de santé juxtapose les « portraits » publics de l'application, de ses utilisateurs potentiels, de leurs rôles actifs et de leurs pratiques d'usage et les témoignages des utilisateurs bénévoles. Cette analyse explore les dimensions des rôles actifs de l'application et de ses utilisateurs tels qu’ils sont délégués par les « portraits » de la technologie et tels qu’ils sont perçus par ses utilisateurs. Cette analyse rend visibles les aspects des rôles actifs et des pratiques des utilisateurs bénévoles au moment de la mise en œuvre de cette technologie dans deux premières régions, avant son adoption ultérieure dans d'autres régions de Suède ainsi qu’au Danemark. La perspective de la recherche médicale a jusqu'à présent dominé les études sur les applications de secourisme. Ces études ont évalué les résultats de l'usage de l'application par les bénévoles et se sont concentrées sur l'examen de l'efficacité de ces applications, par des indicateurs tels que le nombre d'utilisateurs arrivés sur place et le nombre de ceux qui ont participé à la réanimation des personnes victimes. Dans le même temps, ces travaux ont contribué à la construction de discours prometteurs et à des approches instrumentales appliquées pour comprendre les significations et les usages des applications médicales et de santé. En revanche, en s'appuyant sur l'analyse discursive et thématique du matériel de recherche qualitative, cette thèse cherche à mettre en évidence les perspectives des utilisateurs dans leur co-construction de la technologie de secourisme à travers leurs pratiques d'usage de l'application. Par une approche théorique socio-matérielle, elle explore de manière critique les rôles actifs des utilisateurs tels qu'ils sont délégués par les discours des développeurs du projet, des gestionnaires et des évaluateurs de cette technologie médicale et tels qu'ils sont négociés par les utilisateurs dans leurs pratiques quotidiennes. Cette thèse examine tout d'abord les « portraits » de l'application publiés en ligne, de ses utilisateurs et de leurs rôles actifs, mais aussi dans les pratiques de recrutement des utilisateurs et enfin dans une publication de recherche médicale évaluant cette technologie de secourisme. Ensuite, la thèse examine comment les bénévoles décrivent les motifs de leur décision de devenir usagers de l’application, le contexte social de leurs décisions et les significations qu'ils attribuent à leurs pratiques. Troisièmement, la thèse examine comment les récits des bénévoles, en juxtaposition avec les « portraits » en ligne de la technologie SMSlifesaving, représentent les pratiques d'usage de l'application par les bénévoles aux differentes étapes: avant la réception des notifications les informant des cas d'arrêts cardiaques, au moment de la réception de ces notifications, et après leur acceptation.Contribuant au champ de la recherche sociale critique sur les applications médicales et de santé, la thèse met en relief que les utilisateurs de l'application SMSlifesaving et les technologies qu'ils co-construisent ont des rôles actifs. Elle illustre les rôles actifs délégués et négociés par les utilisateurs ; ces derniers lorsqu'ils surmontent les dépendances quotidiennes de l'application et mesurent l'importance de leur travail bénévole, par l’intermédiaire de leur usage de l’application, par rapport à leur travail rémunéré et à leurs engagements de vie privée, développent un engagement consciencieux envers l'application et redéfinissent les promesses médicales de l'application pour les personnes victimes et leurs famillesThis thesis embraces a social science research perspective to examine uses of the app SMSlivräddare (eng. SMSlifesaving), now Heartrunner, dedicated to alert volunteers nearby to assist people suspected to suffer from a cardiac arrest outside hospital. This case study of the uses of the health and medical app juxtaposes the public portrayals of the app, its prospective users, their agencies and use practices with the volunteer users’ own accounts. The analysis explores dimensions of the app’s and its users’ agencies as delegated by the technology’s portrayals and perceived by its users. It renders visible also possibly obscured aspects of the volunteer users’ agencies and practices at the time of the technology’s implementation in the two first regions, before its subsequent adoption in other Swedish regions and in Denmark. A medical research perspective has so far dominated the studies of lifesaving apps. Such research evaluates the patients’ health outcomes resulting from the app use by the volunteers and concentrates on the examination of the efficiency aspects of the app, such as how many users arrived and how many engaged in resuscitating the patients. At the same time, it contributes to the promissory discourses and instrumental approaches applied to understand the meanings and uses of health and medical apps. In contrast, building on the discourse and thematic analysis of the qualitative research material, this thesis seeks to highlight the users’ perspectives in their co-constructing of the SMSlifesaving technology through their app use practices; it embraces a socio-material theoretical approach and critically explores the users’ agencies as delegated by the discourses of the project developers, managers and evaluators of the medical technology and as negotiated by the users in their daily practices. This thesis, first, investigates the public portrayals of the app, its users and their agencies published online, in the user-recruiting practices, and in a medical research publication evaluating the SMSlifesaving technology. Next, it examines how the volunteers’ accounts describe the rationales of their entry into their SMSlifesaving app use practices, the social context embedding their entry and the meanings which they ascribe to their practices. Third, the study investigates how the volunteers’ accounts in juxtaposition to the online portrayals of the SMSlifesaving technology represent the volunteers’ app use before their receptions of the app’s notifications which inform them about cardiac-arrest cases nearby, at the time of reception of such notifications, and following acceptance of such notifications.Contributing to the field of critical social research on health and medical apps, the thesis identifies that both the SMSlifesaving app users and the technologies they co-construct have agencies. It illustrates the users’ agencies delegated and negotiated; the latter when they overcome the app everyday dependencies and judge the app-mediated volunteer work importance versus their paid work and private life commitments, develop dutiful engagement with the app and re-define the app’s medical promises for the patients and their families
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Rocha, Joana Fernandes da. "Understanding APP-dependent neuronal differentiation." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7389.
Повний текст джерелаАнотація:
Mestrado em Biomedicina MolecularAmyloid Precursor Protein (APP) is a type 1 membrane protein that suffers proteolytic cleavages and has been implicated in roles such as cell adherence, survival, migration and differentiation. Although a role in neuritogenesis has been attributed to APP, some contradictory results have been reported regarding the benefits of knocking-down or overexpressing APP. Further, while the addition of the APP proteolytic sAPP (secreted APP) fragment to the cell medium enhances neuritogenesis, the amount of cellular APP and other APP fragments may be deleterious for this process. Further, preliminary work from the Neuroscience laboratory of the Center for Cell Biology indicated that pAPP (APP phosphorylated at the S655 residue) can potentially be crucial in APPmediated neuronal differentiation, for example by increasing APP cleavage to its biological fragment sAPP or APP binding to specific signal transducers. In this work, the capacity of APP and pAPP to mediate neuronal differentiation was tested, in the initial period of retinoic acid (RA)-induced SH-SY5Y cells differentiation. These neuroblastoma cells are a well documented neuronal-like cell model used in neuronal differentiation studies. Several molecular tools were used, including wild-type and phosphomutants APP-GFP. The evaluation of differentiation included neuritogenic output analysis by bright field and epifluorescence microscopy, using various approaches. Namely scoring the number of differentiated cells and performing morphometric analyses of transfected cells and of the all cellular population. The levels of APP and medium secreted sAPP, and of cytoskeleton-related proteins and posttranslational modifications, such as MAP2, Acetylated Tubulin and Actin were also quantified by Western blot analysis, and related to the morphological parameters. Additionally, the potential role of AICD in APP-mediated neuronal differentiation was inferred from pharmacologic assays, where its generation is inhibited. Together the results obtained show that APP, sAPP and AICD modulate neuritogenesis in a complex and well-ordered manner. While long-term increases in APP can be detrimental to neuronal-like differentiation, in an AICD-dependent manner, short-term increases benefit this process in an APP S655 phosphorylation dependent manner, potentially involving sAPP secretion and specific cytoskeleton rearrangements.
A Proteína Precursora de Amilóide de Alzheimer (PPA) é uma proteína membranar tipo 1 sujeita a processamento proteolítico que tem sido associada a funções como adesão celular, sobrevivência, migração e diferenciação. Apesar de lhe terem sido atribuídas funções na neuritogénese, os dados experimentais obtidos até à data que envolveram modulação dos níveis da PPA revelam-se contraditórios. De facto, enquanto a adição do fragmento PPA secretado (PPAs) ao meio celular favorece a neuritogénese, a quantidade de PPA celular e de outros fragmentos da PPA poderão já não constituir um benefício para este processo. Adicionalmente, dados preliminares do laboratório de Neurociências do Centro de Biologia Celular sugerem que a PPAp (PPA fosforilada na S655) poderá ser fundamental na diferenciação neuronal mediada pela PPA, nomeadamente por aumentar a proteólise da PPA a PPAs ou a ligação da PPA a sinais de transdução específicos. No presente trabalho, avaliou-se a capacidade da PPA e PPAp em mediar o período inicial de diferenciação neuronal induzida por ácido retinóico. Para tal recorreu-se a células de neuroblastoma SH-SY5Y, um modelo celular do tipo neuronal bem estabelecido para estudos de diferenciação. Adicionalmente, várias ferramentas moleculares, como PPA-GFP selvagem e fosfomutantes foram usadas. A avaliação da diferenciação incluiu a análise de vários parâmetros neuritogénicos por microscopia de luz (de campo claro e de fluorescência), nomeadamente monitorização de células diferenciadas e análises morfométricas das células transfectadas e da população geral. Os níveis de PPA e PPAs, e de proteínas relacionadas com citosqueleto e suas modificações pós-traducionais (MAP2, Tubulina Acetilada e Actina) também foram quantificados. Além do mais, a influência do DIP na diferenciação neuronal dependente de PPA foi avaliada usando um composto farmacológico para inibir a sua produção. De um modo geral, os resultados obtidos demonstram que a PPA, PPAs e DIP modulam a neuritogénese de um modo complexo e ordenado. Enquanto a indução de níveis altos de expressão de PPA (48h) podem ser detrimentais para a diferenciação tipo-neuronal, de uma forma dependente de DIP, induções mais breves (24h) beneficiam este processo de um modo dependente da fosforilação na S655, potencialmente envolvendo a secreção de PPA e rearranjos específicos do citosqueleto.
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Paz, Sandra Isabel Moreira Pinto Vieira Guerra e. "Phosphorylation-dependent Alzheimer's Amyloid precursor protein (APP) targeting." Doctoral thesis, Universidade de Aveiro, 2006. http://hdl.handle.net/10773/4629.
Повний текст джерелаАнотація:
Doutoramento em BiologiaA Doença de Alzheimer (DA) é uma das doenças neurodegenerativas mais comuns, e apresenta uma incidência mundial de 2-7% em indivíduos com mais de 65 anos e de cerca de 15% em indivíduos acima dos 85 anos de idade. Apesar da sua etiologia multifactorial, há uma correlação bem descrita entre esta patologia e um peptídeo neurotóxico denominado Abeta. Este peptídeo deriva fisiológica e proteoliticamente de uma glicoproteína transmembranar com características de receptor: a Proteína Percursora de Amilóide de Alzheimer (PPA). As possíveis funções fisiológicas da proteína PPA, o seu destino e vias de processamento celulares, conjuntamente com possíveis proteínas celulares que com ela interajam, são assim tópicos de interesse e objectos de investigação científica mundial. Neste contexto tem sido amplamente descrito o envolvimento do processo de fosforilação de proteínas, uma importante modificação pós-transducional que regula muitos e variados acontecimentos intracelulares, na regulação do processamento da PPA. Apesar do exposto, muito pouco é conhecido acerca da fosforilação directa da própria PPA. Esta proteína possui na sua estrutura primária sequências consenso para fosforilação, quer no seu ectodomínio quer no seu domínio intracelular, já descritas como sofrendo fosforilação “in vitro” e “in vivo”. O resíduo Serina 655 pertence a um motivo funcional da APP, 653YTSI656, que forma um sinal de internalização e/ou de “sorting” basolateral. Este domínio é também o local de ligação para a APPBP2, uma proteína que interage com os microtubulos da célula. Embora ainda mal elucidados, os mecanismos pelos quais a fosforilação proteica regula o processamento da PPA parecem incluir uma alteração no tráfego desta proteína, sugerindo que o domínio fosforilável 653YTSI656 desempenha um papel importante nesse processo. Esta dissertação visou assim contribuir para elucidar o papel da fosforilação directa da molécula de APP, mais especificamente no seu resíduo Serina 655, na regulação do direcionamento e tráfego subcelular da proteína, e nas suas possíveis clivagens proteolíticas. De forma a respondermos a essas questões desenvolvemos um modelo experimental para seguir o tráfego intracelular, que usa uma combinação de biologia molecular, técnicas de microscopia de epifluorescência e técnicas de cultura celular. Os resultados obtidos implicam este resíduo como um sinal de direcionamento subcelular da proteína APP, e revelam como o redireccionamento desta proteína por fosforilação favorece um tipo de processamento não amiloidogénico desta. Adicionalmente, a fosforilação do resíduo Serina 655 parece possuir um papel regulador da actividade da PPA como molécula de transdução de sinais. As implicações destas observações na DA e em novas aplicações terapêuticas para a doença são subsequentemente discutidas.
Alzheimer’s Disease (AD) is a common neurodegenerative disease affecting individuals worldwide with an incidence of 2-7% of post-65 and 15% of post-85 years old. This disease is multifactorial in its etiology but central to its pathology is a neurotoxic peptide termed Abeta. This peptide is physiologically derived by a proteolytic process on the transmembranar Alzheimer’s Amyloid Precursor Protein (APP). Protein phosphorylation-dependent APP processing has been widely described and although the mechanisms involved remain far from clarified, alterations in APP trafficking seem to occur as part of the answer. Furthermore, the occurrence of consensus phosphorylation sites in the APP intracellular domain has been known for long, but little was known regarding the direct phosphorylation of APP. Efforts in unravelling the role of these domains are finally being successful in placing them as key control points in APP targeting and processing. Among these consensus sequences, the less studied 653YTSI656 motif forms a characteristic internalisation and/or basolateral sorting signal sequence, and is known to be the binding site for a microtubuleinteracting protein (APPBP2). Phosphorylation of this motif was thus suggested to be involved in APP targeting regulation, hitherto all attempts failed to confirm it or even to reveal substantial evidences. In this project, the role of the 653YTSI656 idomain, and in particular the phosphorylatable serine 655, in APP trafficking and proteolytic processing was studied. In order to address this question a new experimental methodology was developed, which coupled molecular biology, fluorescence imaging, and cell culture techniques. APP point mutants, mimicking serine 655 phosphorylatedand dephosphorylated-status, and tagged with the green-fluorescent protein, were used to study protein trafficking dynamics and processing. Results obtained place serine 655 phosphorylation as a key signal in APP sorting and targeting to specific subcellular locations. Also of high relevance was the observed implication of serine 655 phosphorylation as a regulatory mechanism that maybe involved in controlling APP function as a signal transducer. The implications of these observations in AD pathogenesis and therapeutic approaches are discussed.
FCT - PRAXIS XXI/BD/16218/98
FCT - POCTI/BCI/34349/1999
Project DIADEM, QLK3-CT- 2001/02362
Fundação Calouste Gulbenkian
Fundação Astrazeneca
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Chaput, Dale. "Mass Spectrometry-Based Investigation of APP-Dependent Mechanisms in Neurodegeneration." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5921.
Повний текст джерелаАнотація:
Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly, and as the aging population increases the social and economic burden of AD grows substantially. Pathological hallmarks of AD include the accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs), as well as significant neuron loss. Amyloid plaques consist of aggregated amyloid beta (Aβ) peptide, which is generated from the proteolytic processing of amyloid precursor protein (APP) in addition to several other peptides. While the processing of APP has been characterized, its primary physiological function and its involvement in AD pathology are poorly understood. Developing a greater understanding of the function of APP, and the molecular and cellular functions it is involved in or other proteins it is associated with, could provide insight into its role in AD pathology. To investigate the function of APP695, the neuronal isoform of APP, we used mass spectrometry to compare changes in protein expression and phosphorylation between APP-null B103 and APP695-expressing B103-695 rat neuroblastoma cells.
Mass spectrometry-based proteomics has become a powerful technique for the unbiased identification of proteins from complex mixtures. Quantitative proteomics using labeling techniques, such as stable isotope labeling by amino acids in cell culture (SILAC), allow relative quantitation of multiple samples at once. More recently, with advances in mass spectrometer technology, label-free quantitation has become a reliable quantitative proteomics approach. Additionally, mass spectrometry can be used for the analysis of post-translational modifications, such as phosphorylation, a dynamic modification involved in the regulation of many cellular processes. Phosphoproteomics identifies site-specific phosphorylation and surrounding sequence information, which can be used for consensus motif analysis to provide further information about potential changes in kinase activity. Identifying changes in phosphorylation and kinase activity also provides information about signaling pathways and functions that may be affected by APP695 expression. Comprehensive proteomic and phosphoproteomic datasets can be used to gain insight into the molecular mechanisms that may be regulated by APP695 expression, or involved in AD progression and pathology, leading to the development of novel therapeutic and preventative strategies for AD.
Proteomic and phosphoproteomic analysis of B103 and B103-695 cells identified several significant protein expression and phosphorylation changes that may be mediated by APP695-expression. Global-scale proteomic analysis identified increased expression of Ras and ƴ-synuclein in B103-695 cells, which was further validated in human AD brain tissue. Phosphoproteomic analysis showed increased phosphorylation of Histone H4 at Ser47, and led to the investigation of PCTAIRE-2 (Cdk17), and PCTAIRE-3 (Cdk18) expression, which were all shown to be increased in AD transgenic mouse tissue, culture primary rat neurons treated with Aβ, as well as mild cognitive impairment (MCI) and AD human brain tissue.
Label-free quantitative proteomics was used for the analysis of human brain tissue from the cortex of individuals affected by AD, MCI, Parkinson’s disease (PD), and progressive supranuclear palsy (PSP) compared to cognitively normal, control samples. A number of differentially expressed proteins were identified in AD, MCI, PD, and PSP tissue. Bioinformatic analysis of the comprehensive proteomic datasets from AD, MCI, PD, and PSP human brain tissue identified several proteins consistent with corresponding disease pathology and neurodegeneration, such as inflammatory proteins. While some of the molecular and cellular functions were unique among neurodegenerative diseases, there also appears to be overlap of affected functions, suggesting there may be a more common mechanism of neurodegeneration.
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Haji, Md Sum Hisham. "Educational dependency : a case study on Brunei Darussalam." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335887.
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Braithwaite, Joanne. "Magnetic field and temperature dependence of semiconductor lasers." Thesis, University of Surrey, 1994. http://epubs.surrey.ac.uk/842949/.
Повний текст джерелаАнотація:
The work described in this thesis investigates the effect of modifying the band structure in order to reduce the threshold current and its temperature sensitivity in 1.55mum InGaAsP/InP lasers. The threshold current, amplified spontaneous emission spectrum and lasing wavelength of a bulk InGaAsP laser have been measured in strong magnetic fields up to 14 Tesla, over the temperature range 70 - 240 K. A study of the effect of a magnetic field, B, on the shape of the amplified spontaneous emission spectrum and the rate at which the amplified spontaneous and lasing spectra shift with B, confirms the formation of a quantum wire-like density of states distribution in the conduction band. At high temperature (T ~ 210 K), the value of the measured threshold current in the presence of an applied 14 T magnetic field, is 18% less than that measured with no applied magnetic field. However, at low temperature (T ~ 70 K), the value of Ith measured in the presence of 14 T is 20% greater than that measured with no applied magnetic field. As a result, the temperature sensitivity of In,, denoted by the characteristic temperature T0' is increased from 75 K to 97 K. To investigate the threshold current behaviour, theoretical calculations of gain and spontaneous emission spectra were carried out as a function of B and T. Results from these calculations provide, for the first time, a physical explanation for the surprising experimental observations, revealing that there are two competing effects caused by an increase in the band-edge density of states of a quantum wire laser, namely: (i) The differential gain is increased, which tends to decrease Ith. (ii) The transparency carrier density is increased, which tends to increase Ith. Thus, depending on the magnitude of the gain required to reach threshold, Ith either increases or decreases as a result of an increase in the DoS at the band edge. Hence, if the volume of the laser active region remains constant, introducing further degrees of carrier confinement (i.e. changing the DoS distribution from that of a bulk laser to that of a quantum wire) increases T0' however, it does not necessarily reduce Ith, as first anticipated. Conversely, it is found that modifying the band structure by introducing compressive strain into the active region results in a reduction of Ith but no significant improvement in To. Spontaneous emission spectra emitted from a window etched into the substrate of a compressively strained InGaAsP multi-quantum well laser have been measured as a function of temperature and analysed to reveal information on the temperature dependence of the gain and Auger recombination. In the compressively strained device measured, experimental results suggest that the temperature dependence of the gain is not a dominant factor in directly determining the measured To, but instead, affects the temperature sensitivity indirectly through the non-radiative Auger recombination current, (via the temperature dependence of the threshold carrier concentration, nth (T)). Theoretical calculations suggest that the temperature dependence of nth in this device, is close to that of the case of an ideal quantum well, i.e. nth, T; implying that the differential gain does not show an enhanced temperature dependence, as postulated by other authors. The measured To can be accounted for by the Auger current alone, with a contribution from the temperature dependence of the Auger coefficient, C(T), and also from nth(T). The Auger activation energy was determined from two different methods of analysis and found to be ~ 70 meV, which suggests band-to-band Auger recombination remains a significant loss process in the strained laser investigated.
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Emmett, David William. "An investigation of the role of cognitive style as a mediator of eyewitness memorial performance." Thesis, University of East London, 2003. http://roar.uel.ac.uk/3554/.
Повний текст джерелаАнотація:
Six separate experiments were conducted to investigate the role of Field Dependency (FDI) in determining the susceptibility of eyewitnesses to context reinstatement (CR); their performance in free, cued, and multi-choice recall, and facial identification accuracy; and finally the confidence expressed before and after performing these tasks, and the confidence accuracy relationship (C/AR). Questions were also addressed in relation to the measurement scale status of confidence ratings and the validity and utility of the Calibration / Resolution techniques for analysing the C/AR. Experiments I & II focussed on FDI and CR susceptibility, together with accuracy in free recall, cued recall, and recognition. Experiments III & IV focused on FDI, CR, and recognition. Experiment IV also utilised the Calibration / Resolution technique. Experiment V used a computer presented format to focus on FDI and recognition through simultaneous and sequential line-ups presented upright and inverted. Experiment VI included multi-choice recall testing along with free and cued recall and focussed on FDI, CR, and both correct and incorrect information produced. Experiments I, II, & VI indicated that Field Dependent (FD) participants benefited significantly from CR whilst Field Independent (FI) participants did not. FIs consistently outperformed FDs in cued recall. Experiment VI indicated that for FDs CR in free recall increased correct information and decreased erroneous information, leading to a significant improvement in the 'quality' of the information produced. In cued recall, however, correct information produced by FIs was greater than that produced by FDs and erroneous information lower, leading to a significant difference between FDs and FIs in the 'quality' of cued recall produced. Experiments III and IV indicated a significant superiority in facial recognition for FDs as compared to FIs across time delays of one week and three months in filled line-ups but not in blank. The explicit encoding format and upright and inverted lineups used in experiment V indicated a role for both attentiveness to others and configural processing in the superiority of FDs seen in experiments HI & IV. Results across experiments I, II, and VI indicated that confidence was significantly higher following a free recall test than when assessed at other points during recall testing. In experiment III, IV, & V confidence ratings were higher following exposure to the line-up than confidence ratings given before exposure. Results across all six experiments in relation to the C/AR show a marked level of inconsistency, however the use of the calibration / resolution techniques in experiment IV indicated a level of over-confidence on the part of FIs and underconfidence on the part of FDs that is in keeping with the personality aspects of FDI. In experiment VI the same techniques in relation to cued recall indicate a degree of overconfidence for 'easy' questions and under-confidence for 'hard' questions and point to a new approach to the investigation of the role of 'item difficulty' in determining the C/AR. Overall, the thesis argues that cognitive style is an important factor in predicting when context reinstatement will be beneficial, who will perform better in different recollection and recognition tasks, and how confidence will relate to accuracy.
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Alam, Sadaf Sakina. "Determination of gp120 & Trx80 dependent production of hydrogen peroxide in cell free & cell-dependent systems." Thesis, Södertörns högskola, Institutionen för livsvetenskaper, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2621.
Повний текст джерелаАнотація:
Hydrogen peroxide (H2O2), a reactive oxygen specie (ROS), is most commonly associated with oxidative stress causing cytotoxic effects on living cells. Oxidative stress has been implicated in various conditions including neurodegenerative diseases, autoimmune diseases and cancer. In addition H2O2 is produced as a defense mechanism against pathogens, as being released by activated phagocytes. In recent years, H2O2 has become established as an important regulator of signal transduction in eukaryotic cells. Hydrogen peroxide is generated both intracellularly and extracellularly in response to various stimuli including cytokines and growth factors. There are different mechanisms by which H2O2 is generated, facilitating signal transduction in cells; through NOX-system in miyochondria, via singlet oxygen, receptor/ligand interaction or by redox active metal ions. The HIV glycoprotein 120 (gp120) is associated with HIV dementia and it is known as a neurotoxin that causes neuronal damage. It has been proposed that free radicals may be involved in the pathogenesis caused by gp120. In addition the truncated form of thioredoxin (Trx80) is known to stimulate HIV replication in HIV infected cells, however, the exact mechanism is not known. A possible way both proteins may mediate their activity is by inducing H2O2 production. The aim of this study was to investigate H2O2 production induced by the proteins gp120 and Trx80. In order to detect H2O2 production an assay based on the fluorescent compound Amplex Red, was established. The assay was used to detect H2O2 released by gp120 and Trx80 in a cell-free environment, in a cell-system and in the presence of metal ions (copper ions) with a physiological reductant (ascorbate). We did not detect H2O2 production induced by gp120 and Trx80 respectively, using our assay, however, other ROS such as hydroxyl radicals may have been generated although they were not detectable with our method. Hence, further studies are needed in order to fully understand how gp120 and Trx80 mediate their activity.
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Togher, Paul. "The temperature dependence of the gain in semiconductor lasers." Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/774153/.
Повний текст джерелаАнотація:
The work presented in this thesis is involves two distinct topics. The first area is the main theme of the thesis, and is an investigation of the contribution made by the gain to the temperature sensitivity of long wavelength semiconductor lasers. The second topic is in a separate but related area and consists of an experimental determination of the valence band deformation potential, b, whose magnitude is found to be in good agreement with theoretical prediction. The thesis first presents an overview of the equipment used in the measurements, followed by a review of the available methods for making gain measurements on semiconductor lasers. It is concluded that the Hakki-Paoli method, in conjunction with the Cassidy method, provides the most suitable technique, but the measurement system must be very carefully set up to ensure valid results. The gain-current relationship is then measured in three quantum well lasers with 1.55μm tensile, compressive and unstrained active region respectively, and in two 1.3μm devices, with tensile and compressive quantum wells. It has been observed experimentally that the modal gain, G, varies linearly with the log of the drive current, I, in many quantum well lasers. This relationship was expressed by McIlroy as G= Go in011/0 ). It has been suggested that the strong temperature sensitivity of the threshold current in long wavelength lasers is due to strong temperature dependence of the gain characteristics. We show that the Go parameter is virtually independent of temperature in the 1.5μm devices studied, close to that expected for an ideal laser, while the 1.3μm lasers depart from the ideal case to some degree. The 1.54m devices all have a characteristic temperature, To, of = 70K, in good agreement with what would be expected if non-radiative phonon assisted Auger recombination, with an activation energy of 25meV, dominates the current. The lower To values in the 1.3μm devices of 42K and 50K respectively are consistent with an additional temperature dependence of the differential gain above that predicted in an ideal laser. In both cases it is concluded that Auger recombination makes the dominant contribution to the temperature sensitivity. In the second topic considered, photo voltage measurements are used to determine the energy splitting of the light hole and heavy hole valence subbands in a set of tensilestrained lasers. Using these measurements it is shown that a theoretical model, using the interpolated strain deformation potential determined by Krijn, gives good agreement with experiment.
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Kim, Yookyung. "Compressed Sensing Reconstruction Using Structural Dependency Models." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/238613.
Повний текст джерелаАнотація:
Compressed sensing (CS) theory has demonstrated that sparse signals can be reconstructed from far fewer measurements than suggested by the Nyquist sampling theory. CS has received great attention recently as an alternative to the current paradigm of sampling followed by compression. Initial CS operated under the implicit assumption that the sparsity domain coefficients are independently distributed. Recent results, however, show that exploiting statistical dependencies in sparse signals improves the recovery performance of CS. This dissertation proposes model-based CS reconstruction techniques. Statistical dependency models for several CS problems are proposed and incorporated into different CS algorithms. These models allow incorporation of a priori information into the CS reconstruction problems. Firstly, we propose the use of a Bayes least squares-Gaussian scale mixtures (BLS-GSM) model for CS recovery of natural images. The BLS-GSM model is able to exploit dependencies inherent in wavelet coefficients. This model is incorporated into several recent CS algorithms. The resulting methods significantly reduce reconstruction errors and/or the number of measurements required to obtain a desired reconstruction quality, when compared to state-of-the-art model-based CS methods in the literature. The model-based CS reconstruction techniques are then extended to video. In addition to spatial dependencies, video sequences exhibit significant temporal dependencies as well. In this dissertation, a model for jointly exploiting spatial and temporal dependencies in video CS is also proposed. The proposed method enforces structural self-similarity of image blocks within each frame as well as across neighboring frames. By sparsely representing collections of similar blocks, dominant image structures are retained while noise and incoherent undersampling artifacts are eliminated. A new video CS algorithm which incorporates this model is then proposed. The proposed algorithm iterates between enforcement of the self-similarity model and consistency with measurements. By enforcing measurement consistency in residual domain, sparsity is increased and CS reconstruction performance is enhanced. The proposed approach exhibits superior subjective image quality and significantly improves peak-signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM).Finally, a model-based CS framework is proposed for super resolution (SR) reconstruction. The SR reconstruction is formulated as a CS problem and a self-similarity model is incorporated into the reconstruction. The proposed model enforces similarity of collections of blocks through shrinkage of their transform-domain coefficients. A sharpening operation is performed in transform domain to emphasize edge recovery. The proposed method is compared with state-of-the-art SR techniques and provides high-quality SR images, both quantitatively and subjectively.
Книги з теми "App dependency"
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A, Croon Marcel, and Hagenaars Jacques A, eds. Marginal models: For dependent, clustered, and longitudinal categorical data. New York: Springer, 2009.
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2
1929-, Litwack Gerald, ed. Vitamins and hormones: Advances in research and applications. San Diego: Academic Press, 1995.
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3
Sutherland, Jason. Assessment of the responsiveness of P-glycoprotein promoters to cyclic AMP-dependent protein kinase. Sudbury, Ont: Laurentian University, 2002.
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4
Amirkhizi, Alireza, Jevan Furmanski, Christian Franck, Karen Kasza, Aaron Forster, and Jon Estrada, eds. Challenges in Mechanics of Time-Dependent Materials & Mechanics of Biological Systems and Materials, Volume 2. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-17457-5.
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Gannon, Brian R. Dominant inhibition of cyclic AMP - dependent protein kinase in MCF-7 breast cancer cells: Effects on multidrug resistance. Sudbury, Ont: Laurentian University, 1997.
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Amirkhizi, Alireza, Jacob Notbohm, Nikhil Karanjgaokar, and Frank W. DelRio, eds. Challenges in Mechanics of Time Dependent Materials, Mechanics of Biological Systems and Materials & Micro-and Nanomechanics, Volume 2. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-86737-9.
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Krolczyk, Arkadiusz Jacek. The role of cyclic AMP-dependent protein kinase in the regulation of chloride secretion from the human colonic carcinoma cell line, Caco2. Ottawa: National Library of Canada, 1994.
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8
cAMP signaling: Methods and protocols. New York, NY: Humana Press, 2015.
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1943-, Kalinski Michael I., ed. Exercise and intracellular regulation of cardiac and skeletal muscle. Champaign, IL: Human Kinetics, 1995.
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Acp Intro to Chem Dependency Treatment - Howard Cc. Brooks/Cole, 2013.
Знайти повний текст джерелаЧастини книг з теми "App dependency"
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Duffield, Matthew. "Dependency Injection." In Practical App Development with Aurelia, 51–59. Berkeley, CA: Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-3402-0_5.
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Mandt, Tobias. "Conclusion & Outlook." In Dependence in Buyer-Supplier Relationships, 157–60. Wiesbaden: Springer Fachmedien Wiesbaden, 2018. http://dx.doi.org/10.1007/978-3-658-24252-7_6.
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Ugurlu, Tugberk, Alexander Zeitler, and Ali Kheyrollahi. "Dependency Resolution." In Pro ASP.NET Web API, 415–30. Berkeley, CA: Apress, 2013. http://dx.doi.org/10.1007/978-1-4302-4726-5_14.
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Wojcieszyn, Filip. "Dependency Injection." In ASP.NET Web API 2 Recipes, 269–82. Berkeley, CA: Apress, 2014. http://dx.doi.org/10.1007/978-1-4302-5981-7_9.
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Lopatin, Ben. "Mixed dependency support." In Django Standalone Apps, 103–8. Berkeley, CA: Apress, 2020. http://dx.doi.org/10.1007/978-1-4842-5632-9_15.
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Carmona, René. "Dependence & Multivariate Data Exploration." In Springer Texts in Statistics, 121–95. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8788-3_3.
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Arroyo, Christopher. "Dependency & Domination: Gender & Kant’s Practical Sexual Ethic." In Kant’s Ethics and the Same-Sex Marriage Debate - An Introduction, 105–36. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55733-5_5.
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Lu, Linyuan, Austin Mohr, and László Székely. "Quest for Negative Dependency Graphs." In Springer Proceedings in Mathematics & Statistics, 243–58. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4565-4_21.
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Saeed, Luqman. "The Contexts and Dependency Injection (CDI) API." In Introducing Jakarta EE CDI, 19–70. Berkeley, CA: Apress, 2020. http://dx.doi.org/10.1007/978-1-4842-5642-8_8.
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Basile, Grazia. "Synonymy and Contextual Dependence." In Perspectives in Pragmatics, Philosophy & Psychology, 41–54. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12543-0_3.
Повний текст джерелаТези доповідей конференцій з теми "App dependency"
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Zhi, Yinghao, Tong Li, and Zhen Yang. "Extracting features from app descriptions based on POS and dependency." In SAC '21: The 36th ACM/SIGAPP Symposium on Applied Computing. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3412841.3442120.
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Khazova, S. A., and N. S. Shipova. "Emotional intelligence as a resource for codependent women." In INTERNATIONAL SCIENTIFIC AND PRACTICAL ONLINE CONFERENCE. Знание-М, 2020. http://dx.doi.org/10.38006/907345-50-8.2020.965.977.
Повний текст джерелаАнотація:
The relevance of the study of personal resources is related to the importance of knowledge about the factors that determine a person’s mental health despite living conditions. The research aim was to study the emotional intelligence as a coping resource of codependent women. Sample: 19 women aged 32 to 47 years who are in a close relationship with a chemically dependent person. All women are clients of groups that help relatives of dependent people in Kostroma. Methods: The Mayer — Salovey — Caruso Emotional Intelligence Test 1998 (MSCEIT v. 2.0), adaptation in Russian (Sergienko & Vetrova, 2010); Co-Dependency Assessment Inventory (Weinhold & Weinhold, 2008); Ways of Coping Questionnaire, Folkman & Lazarus, 1988, adaptation in Russian (Kryukova, 2010); Projective technique «Man in the rain» by E. V. Romanova, T. I. Sytko (1992). The results indicate a lower development of emotional intelligence, the ability to understand emotions and consciously manage them, and features of the emotional sphere were found: feelings of insecurity, emotional coldness, impulsiveness and infantile. 47 % of women cope with the situation of dependence of a loved one unconstructively and are prone to excessive self-control, search for social support, and strive to solve the problem in any way. This does not allow you to cope with the dependence of a loved one and with your own codependent state. Regression analysis shows a fairly positive impact on coping behavior of the ability to understand and analyze emotions, use them in solving problems, consciously manage them, and predict their emotional States in the future. On the one hand, distance from the situation is reduced, on the other hand, emotional intelligence creates conditions for confrontation with the dependent behavior of a loved one and for a positive reevaluation of the situation in the context of strengthening one’s own personality. These results allow us to speak about the resource role of emotional intelligence in the situation of codependent relationships.
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Patanaik, Chinmaya Kumar, Ferdous A. Barbhuiya, and Sukumar Nandi. "Obfuscated malware detection using API call dependency." In the First International Conference. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2490428.2490454.
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Silbar, R. R., J. A. Tjon, E. E. van Faassen, J. Dubach та W. M. Kloet. "Model dependence of pp → npπ+ spin observables". У AIP Conference Proceedings Volume 133. AIP, 1985. http://dx.doi.org/10.1063/1.35428.
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Ericson, T. E. O. "Energy dependent nuclear phenomena." In AIP Conference Proceedings Volume 128. AIP, 1985. http://dx.doi.org/10.1063/1.35207.
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Malburg, Jan, Tino Flenker, and Gorschwin Fey. "Property mining using dynamic dependency graphs." In 2017 22nd Asia and South Pacific Design Automation Conference (ASP-DAC). IEEE, 2017. http://dx.doi.org/10.1109/aspdac.2017.7858327.
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Heeb, M. J., F. Espana, M. Geiger, D. Collen, D. C. Stump, and J. H. Griffin. "IMMUNOLOGICAL SIMILARITIES BETWEEN PLASMA AND URINARY PROTEIN C INHIBITORS (PCIs) AND URINARY UROKINASE INHIBITOR (UKI)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643816.
Повний текст джерелаАнотація:
Plasma PCIs have similar MW (∼ 57K), amino acid composition, and heparin dependence (Suzuki et al 1983, JBC 258:163) as urinary UKI (Stump et al 1986, JBC 261:12759). Urinary PCI of ∼ 50K MW has a similar heparin dependence and urokinase (UK) competes with activated protein C (APC) for this PCI (Geiger et al 1986, Circ. 74:11-234). For comparison, three forms of PCI, one from urine and two from plasma, were purified, and each exhibited heparin-dependent UK and APC inhibitory activity and formed heparin-dependent complexes with APC. The APC-PCI complexes were visible on immunoblots (nondenaturing gels) developed using: A) monoclonal anti-UKI + 125I-antimouse IgG; B) polyclonal anti-plasma PCI + 125I-plasma PCI; and C) monoclonal anti-protein C + 125I-protein C. The three forms of purified PCI were detected by methods A and B. Two new bands of APC-inhibitor complexes were seen upon incubation of plasma with APC in the presence of heparin, and the same pattern was visualized by methods A, B, and C. In the absence of heparin, only one APC-inhibitor band was visualized by methods A and B, but two bands were visualized by method C. Plasma immunodepleted of UKI by monoclonal anti-UKI-Sepharose showed no detectable antigen or complexes with APC as visualized by methods A and B. However, the UKI-depleted plasma contained components which formed a reduced amount of complexes with APC as visualized with protein C antibodies, i.e. method C. Heparin stimulates tenfold the PCI activity of normal plasma. Based on amidolytic assays of APC using S-2366, the UKI-depleted plasma was very deficient (< 15%) in heparin-dependent PCI activity, whereas the weak heparin-independent PCI activity was slightly reduced. This indicates that the majority of heparin-dependent PCI activity of plasma is immunologically.related to UKI. These studies suggest that the two slightly different forms of plasma PCI, the urinary UKI, and the urinary PCI are very similar if not identical proteins and that plasma may contain a minor heparin-independent PCI which is not immunologically related to these proteins.
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Venkata, K., N. Ray, and W. Petuskey. "Process Dependent Morphologies of Nano-Particulate Superstructures." In MS&T17. MS&T17, 2017. http://dx.doi.org/10.7449/2017mst/2017/mst_2017_1_3.
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Barber, Peter W. "Theory of morphology dependent resonances." In AIP Conference Proceedings Volume 146. AIP, 1986. http://dx.doi.org/10.1063/1.35791.
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Hamm, Trenton A., and Frederick R. Best. "Gravity dependent flow regime mapping." In AIP Conference Proceedings Volume 387. ASCE, 1997. http://dx.doi.org/10.1063/1.52057.
Повний текст джерелаЗвіти організацій з теми "App dependency"
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Brown, Jenny, Abby Wyers, and Allison Aldous. Groundwater-dependent Biodiversity & Associated Threats: Main Report. The Nature Conservancy, February 2009. http://dx.doi.org/10.3411/col.02232122.
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Brown, Jenny, Abby Wyers, and Allison Aldous. Groundwater-dependent Biodiversity & Associated Threats: Detailed Methods. The Nature Conservancy, February 2009. http://dx.doi.org/10.3411/col.02232237.
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Weerasinghe, Ananda P. Stochastic Control Problems for Processes with Long-Range Dependence & Internet Traffic. Fort Belvoir, VA: Defense Technical Information Center, December 2010. http://dx.doi.org/10.21236/ada545731.
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Asenath-Smith, Emily, Emily Jeng, Emma Ambrogi, Garrett Hoch, and Jason Olivier. Investigations into the ice crystallization and freezing properties of the antifreeze protein ApAFP752. Engineer Research and Development Center (U.S.), September 2022. http://dx.doi.org/10.21079/11681/45620.
Повний текст джерелаАнотація:
Antifreeze proteins (AFPs) allow biological organisms, including insects, fish, and plants, to survive in freezing temperatures. While in solution, AFPs impart cryoprotection by creating a thermal hysteresis (TH), imparting ice recrystallization inhibition (IRI), and providing dynamic ice shaping (DIS). To leverage these ice-modulating effects of AFPs in other scenarios, a range of icing assays were performed with AFPs to investigate how AFPs interact with ice formation when tethered to a surface. In this work, we studied ApAFP752, an AFP from the beetle Anatolica polita, and first investigated whether removing the fusion protein attached during protein expression would result in a difference in freezing behavior. We performed optical microscopy to examine ice-crystal shape, micro-structure, and the recrystallization behavior of frozen droplets of AFP solutions. We developed a surface chemistry approach to tether these proteins to glass surfaces and conducted droplet-freezing experiments to probe the interactions of these proteins with ice formed on those surfaces. In solution, ApAFP752 did not show any DIS or TH, but it did show IRI capabilities. In surface studies, the freezing of AFP droplets on clean glass surfaces showed no dependence on concentration, and the results from freezing water droplets on AFP-decorated surfaces were inconclusive.
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Adam, Zach, and Eran Pichersky. Degradation of Abnormal Proteins in Chloroplasts of Higher Plants. United States Department of Agriculture, August 1994. http://dx.doi.org/10.32747/1994.7568768.bard.
Повний текст джерелаАнотація:
In this study we attempted to get a better understanding of processes involved in the degradation of abnormal proteins i chloroplasts. To achieve this goal, we used a number of complementary approaches. We first characterized the expression of the two subunits of Clp protease. We demonstrated that both of them were expressed in chloroplasts in a constitutive fashion, but the expression of the regulatory subunit ClpC was enhanced by light. We generated a mutant the lumenal protein OEE33 which was targeted to the stroma in in vitro experiments. In the wrong compartment it was found unstable, and characterization of its degradation revealed that it was degraded by a soluble, ATP-dependent serine protease, which are also the characteristics of Clp protease. In search of other homologues of bacterial proteases, we found that chloroplasts contain a homologue of the FtsH protease. It is an ATP-dependent metallo-protease, bound to the stromal side of the thylakoid membrane, whose expression is dependent on light. The gene encodig this protease was cloned and characterized. In attempt to generate Arabidopsis mutant plants impaired in their capability to degrade abnormal chloroplast proteins, we fused the gene for mistargeted OEE33 to the streptomycin-detoxifying gene. This chimeric gene was introduced into Arabodipsis plants, to generate transformed plants. This transformants plants were sensitive to streptomycin due to the rapid turn-over of the chimeric protein. Seeds from these plants were then chemically mutagenised, and seedlings were selected for their capability to grow on streptomycin. The ability of these mutant transformants to grow on streptomycin is presumably due to stabilization of the chimeric protein. These plants will allow us in the future to identify the effected genes, which are likely to be involved in the protein degradation process.
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Miller, James, Anthony Latino, Chandana Konidala, and Raymond Patenaude. Army R-22 refrigerant phase-out strategy. Engineer Research and Development Center (U.S.), March 2021. http://dx.doi.org/10.21079/11681/40039.
Повний текст джерелаАнотація:
R-22 (also known as HCFC-22) is one of the most widely used refrigerants in U.S. Army air-conditioning and refrigeration (AC&R) systems since the phase-out of R-12 refrigerant in 1995. The need to phase out R-22 is attributed to its global warming potential and high ozone-depleting capability. The U.S. Army has tens of thousands of aging AC&R systems that will remain dependent on R-22, or one of the recently developed substitutes for R-22, until they reach the end of their operational life. This project conducted a survey to understand the current R-22 usage and types of R-22 AC&R equipment that are in use across U.S. Army Installation Management Command (IMCOM) installations. This study describes several methods to remove or retrofit R-22 from typical AC&R equipment and implementation strategies to meet the stated goal of eliminating R-22 from IMCOM installations. The scope of this project included the review of BUILDER SMS data for IMCOM installations, which included data on 13,000 pieces of comfort cooling equipment for 31 installations. The report also provides an analysis of several R-22 alternatives and their physical properties and compatibility. Mission critical tactical cooling that uses R-22 refrigerant was not within the scope of this project.
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Byrd, John, John Corlett, Larry Doolittle, William Fawley, Steven Lidia, Gregory Penn, Alex Ratti, et al. R&D Requirements, RF Gun Mode Studies, FEL-2 Steady-StateStudies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary LayoutOption Investigation. Office of Scientific and Technical Information (OSTI), October 2005. http://dx.doi.org/10.2172/883785.
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Hicks, Jacqueline. Environmental Challenges of Digital Transformation in Developing Countries. Institute of Development Studies (IDS), July 2021. http://dx.doi.org/10.19088/k4d.2021.107.
Повний текст джерелаАнотація:
This rapid review synthesises the literature on the environmental risks of four different aspects of digital transformation in developing countries: ICT adoption, digitally-enabled energy efficiency, ride-hailing apps, and big data use. The overall message which runs throughout the diverse literatures and results is that it is not digital technologies that create environmental risks or opportunities, but how they are used. Efficiency gains derived from digital transformation may yet lead developing countries down existing unsustainable development paths if not accompanied by careful, context-dependent policy. For policy-makers seeking to mitigate environmental risks, this means putting the context of digital use at the centre of analysis rather than the technologies themselves. However, the research literature covers more specific aspects of digital transformation. In practice, this report defines digital transformation as: ICT adoption, digitally-enabled energy efficiency, ride-hailing apps, and big data use. These topics were chosen after an initial scoping review of available literature, and because they exemplify a range of the different types of potential digital effects. The literature on the environmental risks of digital transformation is huge and conflicting. This is problematic because it could be easy to cherry pick preferred research results. Several studies noted that there is less research on developing countries than developed countries, but the evidence base is still large. As an evidence review, this report focused on the academic literature, but there is also a large grey literature. Some of the literature has a gender aspect, not covered in this report.
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Bowles, David, Michael Williams, Hope Dodd, Lloyd Morrison, Janice Hinsey, Tyler Cribbs, Gareth Rowell, Michael DeBacker, Jennifer Haack-Gaynor, and Jeffrey Williams. Protocol for monitoring aquatic invertebrates of small streams in the Heartland Inventory & Monitoring Network: Version 2.1. National Park Service, April 2021. http://dx.doi.org/10.36967/nrr-2284622.
Повний текст джерелаАнотація:
The Heartland Inventory and Monitoring Network (HTLN) is a component of the National Park Service’s (NPS) strategy to improve park management through greater reliance on scientific information. The purposes of this program are to design and implement long-term ecological monitoring and provide information for park managers to evaluate the integrity of park ecosystems and better understand ecosystem processes. Concerns over declining surface water quality have led to the development of various monitoring approaches to assess stream water quality. Freshwater streams in network parks are threatened by numerous stressors, most of which originate outside park boundaries. Stream condition and ecosystem health are dependent on processes occurring in the entire watershed as well as riparian and floodplain areas; therefore, they cannot be manipulated independently of this interrelationship. Land use activities—such as timber management, landfills, grazing, confined animal feeding operations, urbanization, stream channelization, removal of riparian vegetation and gravel, and mineral and metals mining—threaten stream quality. Accordingly, the framework for this aquatic monitoring is directed towards maintaining the ecological integrity of the streams in those parks. Invertebrates are an important tool for understanding and detecting changes in ecosystem integrity, and they can be used to reflect cumulative impacts that cannot otherwise be detected through traditional water quality monitoring. The broad diversity of invertebrate species occurring in aquatic systems similarly demonstrates a broad range of responses to different environmental stressors. Benthic invertebrates are sensitive to the wide variety of impacts that influence Ozark streams. Benthic invertebrate community structure can be quantified to reflect stream integrity in several ways, including the absence of pollution sensitive taxa, dominance by a particular taxon combined with low overall taxa richness, or appreciable shifts in community composition relative to reference condition. Furthermore, changes in the diversity and community structure of benthic invertebrates are relatively simple to communicate to resource managers and the public. To assess the natural and anthropo-genic processes influencing invertebrate communities, this protocol has been designed to incorporate the spatial relationship of benthic invertebrates with their local habitat including substrate size and embeddedness, and water quality parameters (temperature, dissolved oxygen, pH, specific conductance, and turbidity). Rigid quality control and quality assurance are used to ensure maximum data integrity. Detailed standard operating procedures (SOPs) and supporting information are associated with this protocol.
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Albright, Jeff, Kim Struthers, Lisa Baril, John Spence, Mark Brunson, and Ken Hyde. Natural resource conditions at Glen Canyon National Recreation Area: Findings & management considerations for selected resources. National Park Service, April 2022. http://dx.doi.org/10.36967/nrr-2293112.
Повний текст джерелаАнотація:
Glen Canyon National Recreation Area (GLCA) encompasses more than 0.5 million ha (1.25 million ac) and extends over 322 km (200 mi) from its northern boundary in southern Utah to its southern boundary in northern Arizona. It is one of the most rugged, remote, and floristically diverse national parks on the Southern Colorado Plateau (Thomas et. al 2005) and has more than 4,900 km (3,045 mi) of waterways flowing through its eight Hydrologic Unit Code (HUC 8) watersheds. GLCA’s larger perennial rivers include the Colorado, Escalante, Dirty Devil, San Juan, and Paria, with smaller perennial and intermittent streams flowing into each of these rivers. After the creation of the Glen Canyon Dam, Lake Powell formed, covering 13% of the park’s total land area when full and the national recreation area attracts over 4 million visitors annually, and in 2019 GLCA ranked 19th highest in recreational visits out of all national parks. The National Park Service Natural Resource Condition Assessment Program selected GLCA to pilot its new NRCA project series. NRCA projects evaluate the best available science to provide park managers with reliable, actionable information pertaining to natural resource conditions in their park. For the park-selected focal study resources, this includes consideration of drivers and stressors known or suspected of influencing resource conditions; assessment of current conditions and trends for indicators of condition; and potential near-term and future activities or actions managers can consider, improving their knowledge and management of natural resources in parks. For focal resources that lack adequate data to assess current conditions, a gap analysis is provided (in lieu of a condition assessment) to highlight the present status of knowledge of the resource and to suggest useful indicators, data, and studies for further consideration and investigation. Park managers are encouraged to identify information needs and pose questions during the NRCA scoping process, with the understanding that information will be provided to help address those needs and answer those questions when possible. For a comprehensive list of GLCA managers’ questions and needs, please refer to Appendix A, Table A-1. The focus of GLCA’s NRCA study was the water-dependent resources—tinajas, springs & seeps, including water quality, riparian zone, amphibians, including the northern leopard frog (Lithobates pipiens), and small, native fishes—that are found off the mainstem Colorado River. Managers were interested in these particular environments and the natural resources that depend on them because they are less studied, and the habitats are “biodiversity hotspots” due to the intersection of complex desert and freshwater ecosystems in a region limited by water. The following summaries highlight the key findings of GLCA’s focal resource drivers and stressors (Chapter 2), states (Chapter 3), and manager responses (Chapter 4).