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Автор: Grafiati
Опубліковано: 6 вересня 2023

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Статті в журналах з теми "ApoL9"

1

Hawkins, Gregory A., David J. Friedman, Lingyi Lu, David R. McWilliams, Jeff W. Chou, Satria Sajuthi, Jasmin Divers, et al. "Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression." American Journal of Nephrology 42, no. 2 (2015): 99–106. http://dx.doi.org/10.1159/000439448.

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Анотація:
Background: In African Americans (AAs), APOL1 G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern. Additional risk and protective genetic variants may be present near the APOL1 loci, since earlier age ESKD is observed in some AAs with one APOL1 renal-risk variant, and because the adjacent gene MYH9 is associated with nephropathy in populations lacking G1 and G2 variants. Methods: Re-sequencing was performed across a ∼275 kb region encompassing the APOL1-APOL4 and MYH9 genes in 154 AA cases with non-diabetic ESKD and 38 controls without nephropathy who were heterozygous for a single APOL1 G1 or G2 risk variant. Results: Sequencing identified 3,246 non-coding single nucleotide polymorphisms (SNPs), 55 coding SNPs, and 246 insertion/deletions. No new coding variations were identified. Eleven variants, including a rare APOL3 Gln58Ter null variant (rs11089781), were genotyped in a replication panel of 1,571 AA ESKD cases and 1,334 controls. After adjusting for APOL1 G1 and G2 risk effects, these variations were not significantly associated with ESKD. In subjects with <2 APOL1 G1 and/or G2 alleles (849 cases; 1,139 controls), the APOL3 null variant was nominally associated with ESKD (recessive model, OR 1.81; p = 0.026); however, analysis in 807 AA cases and 634 controls from the Family Investigation of Nephropathy and Diabetes did not replicate this association. Conclusion: Additional common variants in the APOL1-APOL4-MYH9 region do not contribute significantly to ESKD risk beyond the APOL1 G1 and G2 alleles.
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2

Scales, Suzie J., Nidhi Gupta, Ann M. De Mazière, George Posthuma, Cecilia P. Chiu, Andrew A. Pierce, Kathy Hötzel, et al. "Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes." Journal of the American Society of Nephrology 31, no. 9 (August 6, 2020): 2044–64. http://dx.doi.org/10.1681/asn.2019080829.

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BackgroundAPOL1 is found in human kidney podocytes and endothelia. Variants G1 and G2 of the APOL1 gene account for the high frequency of nondiabetic CKD among African Americans. Proposed mechanisms of kidney podocyte cytotoxicity resulting from APOL1 variant overexpression implicate different subcellular compartments. It is unclear where endogenous podocyte APOL1 resides, because previous immunolocalization studies utilized overexpressed protein or commercially available antibodies that crossreact with APOL2. This study describes and distinguishes the locations of both APOLs.MethodsImmunohistochemistry, confocal and immunoelectron microscopy, and podocyte fractionation localized endogenous and transfected APOL1 using a large panel of novel APOL1-specific mouse and rabbit monoclonal antibodies.ResultsBoth endogenous podocyte and transfected APOL1 isoforms vA and vB1 (and a little of isoform vC) localize to the luminal face of the endoplasmic reticulum (ER) and to the cell surface, but not to mitochondria, endosomes, or lipid droplets. In contrast, APOL2, isoform vB3, and most vC of APOL1 localize to the cytoplasmic face of the ER and are consequently absent from the cell surface. APOL1 knockout podocytes do not stain for APOL1, attesting to the APOL1-specificity of the antibodies. Stable re-transfection of knockout podocytes with inducible APOL1-G0, -G1, and -G2 showed no differences in localization among variants.ConclusionsAPOL1 is found in the ER and plasma membrane, consistent with either the ER stress or surface cation channel models of APOL1-mediated cytotoxicity. The surface localization of APOL1 variants potentially opens new therapeutic targeting avenues.
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3

Chen, Teresa K., Aditya L. Surapaneni, Dan E. Arking, Christie M. Ballantyne, Eric Boerwinkle, Jingsha Chen, Josef Coresh, et al. "APOL1 Kidney Risk Variants and Proteomics." Clinical Journal of the American Society of Nephrology 17, no. 5 (April 26, 2022): 684–92. http://dx.doi.org/10.2215/cjn.14701121.

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Анотація:
Background and objectivesThe APOL1 risk variants (G1 and G2) are associated with kidney disease among Black adults, but the clinical presentation is heterogeneous. In mouse models and cell systems, increased gene expression of G1 and G2 confers cytotoxicity. How APOL1 risk variants relate to the circulating proteome warrants further investigation.Design, setting, participants, & measurementsAmong 461 African American Study of Kidney Disease and Hypertension (AASK) participants (mean age: 54 years; 41% women; mean GFR: 46 ml/min per 1.73 m2), we evaluated associations of APOL1 risk variants with 6790 serum proteins (measured via SOMAscan) using linear regression models. Covariates included age, sex, percentage of European ancestry, and protein principal components 1–5. Associated proteins were then evaluated as mediators of APOL1-associated risk for kidney failure. Findings were replicated among 875 Atherosclerosis Risk in Communities (ARIC) study Black participants (mean age: 75 years; 66% women; mean eGFR: 67 ml/min per 1.73 m2).ResultsIn the AASK study, having two (versus zero or one) APOL1 risk alleles was associated with lower serum levels of APOL1 (P=3.11E-13; P=3.12E-06 [two aptamers]), APOL2 (P=1.45E-10), CLSTN2 (P=2.66E-06), MMP-2 (P=2.96E-06), SPOCK2 (P=2.57E-05), and TIMP-2 (P=2.98E-05) proteins. In the ARIC study, APOL1 risk alleles were associated with APOL1 (P=1.28E-11); MMP-2 (P=0.004) and TIMP-2 (P=0.007) were associated only in an additive model, and APOL2 was not available. APOL1 high-risk status was associated with a 1.6-fold greater risk of kidney failure in the AASK study; none of the identified proteins mediated this association. APOL1 protein levels were not associated with kidney failure in either cohort.ConclusionsAPOL1 risk variants were strongly associated with lower circulating levels of APOL1 and other proteins, but none mediated the APOL1-associated risk for kidney failure. APOL1 protein level was also not associated with kidney failure.
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4

Arunmanee, Wanatchaporn, Richard K. Heenan, and Jeremy H. Lakey. "Determining the amphipol distribution within membrane-protein fibre samples using small-angle neutron scattering." Acta Crystallographica Section D Structural Biology 74, no. 12 (November 30, 2018): 1192–99. http://dx.doi.org/10.1107/s205979831800476x.

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Анотація:
Detergent micelles can solubilize membrane proteins, but there is always a need for a pool of free detergent at the critical micellar concentration to maintain the micelle–monomer equilibrium. Amphipol polymeric surfactants (APols) have been developed to replace conventional detergents in membrane-protein studies, but the role of free amphipol is unclear. It has previously been shown that the removal of free APol causes monodisperse outer membrane protein F (OmpF) to form long filaments. However, any remaining APol could not be resolved using electron microscopy. Here, small-angle neutron scattering with isotope contrast matching was used to separately determine the distributions of membrane protein and amphipol in a mixed sample. The data showed that after existing free amphipol had been removed from monodisperse complexes, a new equilibrium was established between protein–amphipol filaments and a pool of newly liberated free amphipol. The filaments consisted of OmpF proteins surrounded by a belt of Apol, whilst free oblate spheroid micelles of Apol were also present. No indications of long-range order were observed, suggesting a lack of defined structure in the filaments.
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5

Anderson, Blair R., Erica E. Davis, Marilyn J. Telen, and Allison E. Ashley-Koch. "In Vivo Modeling Of Genetic Mechanisms Associated With Sickle Cell Disease Nephropathy." Blood 122, no. 21 (November 15, 2013): 2224. http://dx.doi.org/10.1182/blood.v122.21.2224.2224.

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Abstract End-organ damage in patients with sickle cell disease (SCD) has become an emergent clinical priority over recent decades due to the increased lifespan of affected individuals. Renal failure (ESRD), which occurs in 4-12% of SCD patients and is strongly associated with early mortality, has become a particular concern. The detection of SCD nephropathy (SCDN) relies on relatively late markers of the disease process, namely proteinuria and reduced glomerular filtration rate (GFR). Therefore, at-risk SCD patients cannot be identified prior to end-organ damage. A genomic region on human chromosome 22 containing two genes, MYH9 and APOL1, has been associated with non-SCD nephropathy, although the primary gene responsible has remained elusive due to strong linkage disequilibrium in this region. Our group demonstrated that both MYH9 and APOL1 are strong, independent genetic predictors of risk for proteinuria in SCD and interact to affect GFR (Ashley-Koch et al., 2011). We have now used zebrafish as a model to study the contribution of each gene (myh9 and apol1) to kidney function and filtration. To test independent effects of the knockdown of myh9 or apol1, we injected morpholino (MO) antisense oligonucleotides in wild-type zebrafish embryos; this resulted in generalized edema (64% [myh9-MO] and 58% [apol1-MO], both significantly different compared to 3% of control embryos) and reduced glomerular filtration (as measured by quantitative dextran clearance; myh9-MO p=0.047 and apol1-MO p=0.042 when compared to control embryos) for both gene suppression models. Each morphant phenotype was rescued significantly by co-injection of each respective wild type human MYH9 (p=0.001) and APOL1 (p=0.043) mRNA. Importantly, co-injection of human mRNA corresponding to other APOL gene family members did not significantly rescue the observed apol1-MO phenotype, suggesting that apol1 is indeed the functional ortholog to the human gene. Next, we investigated the possibility of a genetic interaction between MYH9 and APOL1 by co-suppression of each of the zebrafish orthologous genes. We observed no additive or synergistic effects due to the co-suppression. Instead, the double morphants were indistinguishable from the myh9 morpholino alone, and neither single morpholino could be rescued by the human mRNA of the other gene. These data suggest that MYH9 and APOL1 may function independently but converge on the same biological process to affect risk of SCDN. In addition to evaluating the effects of candidate gene suppression in wild-type models, we have begun to utilize anemic zebrafish models described previously (Shah et al., 2012). Our preliminary work suggests that the myh9 knockdown phenotype is exacerbated under anemic stress. Ongoing efforts are aimed at identifying novel genetic contributions to SCDN through genome-wide association analysis and exome sequencing of extreme phenotypes in SCD patients, with functional evaluation of putative genetic candidates in our zebrafish model. By offering new insights into the contribution of genes that regulate renal function, these results further our understanding of the pathogenesis of SCDN and may provide genetic markers for the identification of at-risk SCD patients prior to the onset of kidney dysfunction. Disclosures: No relevant conflicts of interest to declare.
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6

Wang, Zhixing, and Fan Wang. "Identification of Ten-Gene Related to Lipid Metabolism for Predicting Overall Survival of Breast Invasive Carcinoma." Contrast Media & Molecular Imaging 2022 (July 11, 2022): 1–16. http://dx.doi.org/10.1155/2022/8348780.

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Анотація:
Background. Predicting the risk of poor prognosis of breast cancer is crucial to treating breast cancer. This study investigated the prognostic assessment of 10 lipid metabolism-related genes constructed as breast cancer models based on this study. Methods. The TCGA database was used to obtain clinical information and expression data of breast cancer patients, and GSEA analysis and univariate and multivariate Cox proportional risk regression models were performed to identify lipid metabolism genes closely associated with overall survival (OS) of breast cancer patients and to construct a prognostic risk score model based on lipid metabolism gene markers. The Kaplan–Meier method was used to analyze the survival status of patients with high and low-risk scores, and ROC curves assessed the accuracy of this risk score. Finally, the relationship between this risk score and clinicopathological characteristics of BRCA was analyzed in a stratified manner, and the validity of this risk score as an independent prognostic factor was determined using univariate and multivariate Cox regression analyses. Results. One hundred and forty-four differentially expressed lipid metabolism-related genes were identified in cancer and paracancerous tissues in BRCA, 21 of which were associated with overall survival (OS) in BRCA P < 0.05 . Univariate and multivariate Cox analyses revealed that age, grade, and risk score were independent prognostic factors for BRCA. Multivariate Cox regression analysis further identified APOL4, NR1H3, SLC25A5, APOL3, OSBPL1A, DYNLT1, IMMT, MAP2K6, ZDHHC8, and RAB2A lipid metabolism-related genes as independent prognostic markers for BRCA. A prognostic risk score model was developed by labeling lipid metabolism genes with these 10 genes, and patients with BRCA with high-risk scores in the model sample had significantly worse OS than those with low-risk P < 0.01 . The ROC curve area (AUC) of this risk score model was 0.712. Conclusion. By mining the TCGA database, we identified 10 lipid metabolism-related genes APOL4, NR1H3, SLC25A5, APOL3, OSBPL1A, DYNLT1, IMMT, MAP2K6, ZDHHC8, and RAB2A, which are closely related to the prognosis of BRCA patients, and constructed a prognostic risk scoring system based on 10 lipid metabolism genes tags.
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7

Uzureau, Sophie, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H. Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, et al. "APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin." Cell Reports 30, no. 11 (March 2020): 3821–36. http://dx.doi.org/10.1016/j.celrep.2020.02.064.

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8

Heneghan, J. F., D. H. Vandorpe, B. E. Shmukler, J. A. Giovinazzo, J. Raper, D. J. Friedman, M. R. Pollak, and S. L. Alper. "BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins." American Journal of Physiology-Cell Physiology 309, no. 5 (September 1, 2015): C332—C347. http://dx.doi.org/10.1152/ajpcell.00142.2015.

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Анотація:
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes present uniquely in individuals of West African ancestry each encode APOL1 variants resistant to serum resistance-associated protein, and each confers substantial resistance to human African sleeping sickness. In contrast to the dominantly inherited anti-trypanosomal activity of APOL1, recessive inheritance of these two trypanoprotective APOL1 alleles predisposes to kidney disease. Proposed mechanisms of APOL1 toxicity have included BH3 domain-dependent autophagy and/or ion channel activity. We probed these potential mechanisms by expressing APOL1 in Xenopus laevis oocytes. APOL1 expression in oocytes increased ion permeability and caused profound morphological deterioration (toxicity). Coexpression of BCL2 family members rescued APOL1-associated oocyte toxicity in the order MCL1 ∼ BCLW > BCLXL ∼ BCL2A1 ≫ BCL2. Deletion of nine nominal core BH3 domain residues abolished APOL1-associated toxicity, but missense substitution of the same residues abolished neither oocyte toxicity nor its rescue by coexpressed MCL1. The APOL1 BH3 domain was similarly dispensable for the ability of APOL1 to rescue intact mice from lethal trypanosome challenge. Replacement of most extracellular Na+ by K+ also reduced APOL1-associated oocyte toxicity, allowing demonstration of APOL1-associated increases in Ca2+ and Cl− fluxes and oocyte ion currents, which were similarly reduced by MCL1 coexpression. Thus APOL1 toxicity in Xenopus oocytes is BH3-independent, but can nonetheless be rescued by some BCL2 family proteins.
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9

Blessing, Natalya A., Zhenzhen Wu, Sethu M. Madhavan, Jonathan W. Choy, Michelle Chen, Myung K. Shin, Maarten Hoek, John R. Sedor, John F. O’Toole, and Leslie A. Bruggeman. "Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys." PLOS ONE 16, no. 6 (June 17, 2021): e0253197. http://dx.doi.org/10.1371/journal.pone.0253197.

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Анотація:
The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies have minimized a causal role for the circulating APOL1 protein, thus efforts to understand kidney pathogenesis have focused on APOL1 expressed in renal cells. Of the kidney cells reported to express APOL1, the proximal tubule expression patterns are inconsistent in published reports, and whether APOL1 is synthesized by the proximal tubule or possibly APOL1 protein in the blood is filtered and reabsorbed by the proximal tubule remains unclear. Using both protein and mRNA in situ methods, the kidney expression pattern of APOL1 was examined in normal human and APOL1 bacterial artificial chromosome transgenic mice with and without proteinuria. APOL1 protein and mRNA was detected in podocytes and endothelial cells, but not in tubular epithelia. In the setting of proteinuria, plasma APOL1 protein did not appear to be filtered or reabsorbed by the proximal tubule. A side-by-side examination of commercial antibodies used in prior studies suggest the original reports of APOL1 in proximal tubules likely reflects antibody non-specificity. As such, APOL1 expression in podocytes and endothelia should remain the focus for mechanistic studies in the APOL1-mediated kidney diseases.
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10

Pratt, Cindy C., and Paul M. M. Weers. "Lipopolysaccharide binding of an exchangeable apolipoprotein, apolipophorin III, from Galleria mellonella." Biological Chemistry 385, no. 11 (November 1, 2004): 1113–19. http://dx.doi.org/10.1515/bc.2004.145.

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Анотація:
AbstractA new role of apolipophorin III (apoLp-III) as an immune activator has emerged recently. To gain insight into this novel function, the interaction of apoLp-III with lipopoly-saccharide (LPS) was investigated. ApoLp-III fromGalleria mellonellawas incubated with LPS fromEscherichia coliO55:B5, and analyzed by non-denaturing polyacrylamide gel electrophoresis (PAGE). Protein staining showed that apoLp-III mobility was significantly reduced. In addition, silver and LPS fluorescent staining demonstrated that LPS mobility was increased upon incubation with apoLp-III. This result suggests association of apoLp-III with LPS. Sodium dodecyl sulfate (SDS) PAGE analysis showed decreased apoLp-III mobility upon LPS addition, indicative of LPS apoLp-III interaction in the presence of SDS. The unique tyrosine residue that resides in apoLp-III was used to provide additional evidence for LPS binding interaction. In the absence of LPS, apoLp-III tyrosine fluorescence was relatively low. However, LPS addition resulted in a progressive increase in the fluorescence intensity, indicating tertiary rearrangement in the environment of tyrosine 142 upon LPS interaction. Other well-characterized apoLp-IIIs were also examined for LPS binding.Manduca sexta,Bombyx moriandLocusta migratoriaapoLp-III were all able to interact with LPS. The ability of apoLp-III to form complexes with LPS supports the proposed role of apoLp-III in innate immunity.
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Більше джерел

Дисертації з теми "ApoL9"

1

Fontaine, Frédéric. "APOL-Mediated trypanolytic activity." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209246.

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Анотація:
Apolipoprotein L1 (APOL1) is a human-specific serum protein bound to high-density lipoprotein (HDL) particles. This protein allows human resistance to infection by African trypanosomes except for two subspecies, Trypanosoma brucei rhodesiense and T. b. gambiense, the causative agents of sleeping sickness or African trypanosomiasis. This disease infects 20 000 people in sub-Saharan Africa and without treatment, infection is almost always fatal. T. b. rhodesiense resists APOL1 through direct protein neutralization by the Serum Resistance-Associated (SRA) protein. T. b. gambiense does not express SRA, and its mechanism of resistance to APOL1 is orchestrated upon a recently characterized multifactorial defense mechanism.

The mechanism by which the human serum sensitive parasites are killed following APOL1 uptake is described as the result of the lysosomal swelling induced by the generation of ionic pores within the lysosomal membrane.

We show here that preventing the osmotic lysosomal swelling in a hyperosmotic culture condition does not prevent the cell death. In addition, APOL1 appears to trigger some programmed cell death events in the cell such as a fast mitochondrial depolarization followed by a DNA laddering and fragmentation. Furthermore, we show an implication of the endonuclease G (TbEndoG), known to be a key actor in the regulation of cell death process and a kinesin (TbKIFC1), which might be the transporter of APOL1 for the endosomes to the mitochondrion.

In addition, by producing different recombinant human APOL proteins in E. coli and test their activity on T. brucei, we were able to show that APOL3, an other member of the APOL family, also possesses a trypanolytic activity like APOL1 beneath the fact it is not a secreted protein. APOL3 does not only kill T. b. brucei but is also able to lyse APOL1-resistant subspecies such as rhodesiense and gambiense, in vitro and confirmed in vivo when the recombinant APOL3 were injected in infected mice. A beginning of an action mechanism is described herein showing a pH-independent activity for this protein oppositely to APOL1, conferring its specificity.

It is thus conceivable to use this recombinant protein as a first step of a potent curative agent against gambiense or rhodesiense since the few currently available drugs for treatment of African trypanosomiasis, that are outdated, show problems with toxicity and resistance.

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L’ Apolipoprotéine L1 (APOL1) est une protéine sérique humaine associée aux lipoprotéines de haute densité (HDL). Cette protéine confère la résistance à l'infection des trypanosomes africains à l'exception des deux sous-espèces, Trypanosoma brucei rhodesiense et T. b. gambiense, les agents responsables de la maladie du sommeil ou trypanosomiase africaine. Cette maladie infecte 20 000 personnes en Afrique sub-saharienne et en l'absence de traitement, l'infection est presque toujours mortelle. T. b. rhodesiense résiste à l’APOL1 grâce à une neutralisation directe d’APOL1 par une protéine appelé SRA (Serum Resistant-Associated). T. b. gambiense n'exprime pas SRA, et sa résistance à l’APOL1 est orchestrée par un mécanisme de défense multifactorielle récemment caractérisé 1.

Le mécanisme par lequel les parasites sensibles au sérum humain sont tués suivant l’entrée de l’APOL1 est décrit comme le résultat d’un gonflement du lysosome induit par la génération de pores ioniques à l'intérieur de la membrane lysosomiale2. Nous montrons ici que le gonflement osmotique du lysosome peut être empêché en condition de culture hyper osmotique, sans néanmoins empêcher la mort de la cellule. En outre, l’APOL1 semble déclencher des événements de mort cellulaire programmée dans la cellule, tels qu’une dépolarisation mitochondriale rapide suivie d'une fragmentation de l’ADN. De plus, nous montrons une implication de l'endonucléase G (TbEndoG), connu pour être un acteur clé dans la régulation du processus de mort cellulaire et d’une kinésine (TbKIFC1) qui pourrait avoir le rôle de transporter l’APOL1 des endosomes vers la mitochondrie.

Nous avons également pu montrer que l’APOL3, un autre membre de la famille des APOLs humaines, possède tout comme l’APOL1, une activité trypanolytique bien que cette protéine ne soit pas sécrétée en condition physiologique. De manière intéressante, l’APOL3 ne tue pas seulement T. b. brucei, mais est également capable de tuer les sous-espèces résistantes à l’APOL1 tels que rhodesiense et gambiense, in vitro et in vivo lorsque de l’APOL3 recombinante est injectée dans des souris infectées. La spécificité d’action de l’APOL3 pourrait être liée à une indépendance au pH, au contraire de l’APOL1. Il pourrait être envisagé d'utiliser cette protéine recombinante comme agent curatif contre gambiense ou rhodesiense du fait que les médicaments actuellement disponibles pour le traitement de la trypanosomiase africaine montrent des problèmes de toxicité et de résistance.


Doctorat en Sciences
info:eu-repo/semantics/nonPublished

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2

Vega, Ramírez Luis Ramón. "Homero y los mitos: apolo y dionisos." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2018. http://hdl.handle.net/20.500.11799/80226.

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Анотація:
La importancia de la filosofía griega en la historia del desarrollo del pensamiento del hombre tiene un valor incalculable, enigmático y en ocasiones oscuro para los estudiosos de dicho tema. Partir desde esta premisa nos permitimos hacer el recorrido del mundo homérico, el mundo de los dioses y de los hombres. Homero influenciado por toda la tradición espiritual y toda la cosmogonía que envolvía a la sociedad griega crea las dos más grandes y épicas historias que envuelven a dioses y hombre: La Ilíada y La Odisea. A partir del análisis de estas grandes obras, proponemos la posibilidad del nacimiento del pensamiento articulado y lógico, a lo que Platón llama filosofía, más aún, añadimos dos elementos fundamentales en el espíritu griego: lo apolíneo y lo dionisíaco. Sostenemos que las grandes hazañas de los héroes que encontramos en la obra homérica siempre se sitúan y desarrollan entre lo artístico, mesurado, bello (Apolo) y lo grotesco, caótico e inconmensurable (Dionisos). Todo esto será posible mediante un elemento didáctico antiquísimo: el mito. El valor del mito como método, forma y estructura del conocimiento es innegable y en el presente trabajo buscamos hacerlo evidente, más aún, nos preguntamos y respondemos cuál sería la importancia de rescatarlo en nuestros días.
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3

Čermák, Jaromír. "Analýza výsledku hospodaření a rentability firmy Apoly, s.r.o." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-72034.

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Анотація:
The main goal of my thesis is assessment of financial situation of Apoly, s.r.o. through analysis of profit and analysis of profitability in period from 2005 to 2009. The first part deals with theoretical-methodological base of analysis. Second part of my thesis deals with practical aplication of analysis' methods. Evaluation of obtained results is at last part.
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4

COSTA, Marcelo Monteiro. "Bestiário do Apolo: a dimensão trágica e inquietante da beleza." Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/23657.

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CAPES
O presente trabalho é uma investigação sobre a dimensão trágica da beleza, ou a relação entre o belo e o inquietante (unheimlich), que permeia o fascínio da experiência estética ou da ordem do sensível. Como o próprio título sugere, a pesquisa parte da composição dos impulsos artísticos apolíneo e dionisíaco, para então reivindicar a face inquietante e trágica da beleza, ou o lado obscuro e perturbador na aparência resplandecente de Apolo. Ao retomar o conceito do belo através de uma harmonia dos contrários ou de uma poética do encontro entre o bestial e o rigor da forma, entre a graça e a crueldade humana, entre a razão e a vontade, a intenção é restabelecer e ressignificar as concepções estéticas que viam no belo e no inquietante não campos de atuação opostos que se excluem, mas componentes de uma beleza insondável que inquieta e perturba em seu caráter inapreensível. Uma beleza capaz de trazer à tona aquilo que era pra ser mantido oculto ou em segredo. Num segundo momento, a concepção do unheimlich como algo da ordem do estranho-familiar é retomada a partir das narrativas de retorno à casa, especialmente A parábola do filho pródigo. A casa enquanto abrigo é aqui tomada como refúgio e lugar do repouso contra a ameaça da noite que inquieta e perturba. A casa em sua dimensão estética, no confronto entre o que é heimlich e doméstico, e o unheimlich ou estranho. A construção do lar enquanto elemento reconfortante sofre aqui a ameaça da dimensão trágica. É dentro dessa prerrogativa da fruição estética como uma experiência da ordem do estranho-familiar que o trabalho consolida sua tese. Uma forma retórica de reafirmar que mesmo dentro de estruturas estabilizadoras, como o conceito apolíneo de beleza na estética, ou a volta ao "lar doce lar", há sempre uma dimensão trágica e perturbadora a se manifestar e provocar fascínio.
The present study is an investigation about the tragic dimension of beauty, or the relationship between the beauty and the uncanny (unheimlich), which permeates the fascination of aesthetic experience or of a sensitive percept. As the title suggests, the research stems from the composition of Apollonian and Dionysian artistic impetus, in order to reclaim the disturbing and tragic face of beauty, or the obscure and disruptive side of the bright appearance of Apollo. By resuming the concept of beauty throughout a harmony of opposites or a poetic of the encounter of the bestial and the logical form, of human grace and cruelty, of rationality and will, the intention is to recover and reframe the aesthetic notion that used to perceive the beauty and the uncanny not as opposite scopes of work that exclude each other, but as components of an inconceivable beauty which disquiets and disturbs within its unreachable nature. A beauty that is capable of eliciting what should be kept occult or in secret. In a second moment, the notion of unheimlich as something in the strange-familiar category is took up from narratives of returning home, specially the parable of the prodigal son. The house as a shelter is here taken as a refuge and resting place against the threat of the night that troubles and terrifying. The house in its aesthetic dimension, in the confrontation between what is heimlich and domestic, and the unheimlich or stranger. The framing of home as a warming element is here threatened by the tragic dimension. Within this prerogative of aesthetic fruition as an experience in the strangefamiliar category, the work consolidates its theory. A rhetorical way of reassuring that even within the stabiliser structures, as the Apollonian concept of beauty in aesthetics, or the returning to “home sweet home”, there is always a tragic and disturbing dimension to arise and cause fascination.
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Barros, Marcio Benchimol. "Apolo e Dionisio : arte, filosofia e critica da cultura no primeiro Nietzsche." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/279163.

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Анотація:
Orientador: Oswaldo Giacoia Jr
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas
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Resumo: Não informado
Abstract: Not informed.
Mestrado
Mestre em Filosofia
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Eufr?sio, Jos? Jefferson Gomes. "Apolo, Narciso e Dion?sio: o corpo masculino na Revista Mens Health." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14613.

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Esta pesquisa aborda a rela??o entre o corpo e a est?tica, compreendida como padr?o corporal, com o objetivo de analisar o corpo masculino na Revista Men?s Health. A Revista em pauta ? uma publica??o mensal da Editora Abril, estando presente em mais de 43 pa?ses. A metodologia utilizada ? a an?lise de conte?do como proposta por Bardin (1979), visando identificar sentidos sobre o corpo masculino divulgado nessa m?dia, especificamente na se??o Fitness. O corpus de an?lise foi composto por 12 edi??es da revista, veiculadas de janeiro a dezembro do ano 2011. Elaboramos fichas de identifica??o para todas as mat?rias contidas no sum?rio da Se??o Fitness e, em seguida, fizemos os perfis das mat?rias construindo cinco categorias tem?ticas: Apar?ncia, Investimentos no corpo, Individualismo, Consumo, Bem-estar. A Men?s Health, atrav?s de suas imagens e discursos, apresenta v?rios conselhos e recomenda??es que apontam caminhos e atitudes a serem seguidos, influenciando o homem a ser jovem, belo e saud?vel. A partir da an?lise realizada, pode-se afirmar que na Revista Men?s Health a apar?ncia encontra-se ligada a uma ideia de um corpo magro e musculoso. Para a obten??o do corpo propagado pela revista, s?o necess?rios v?rios investimentos e pr?ticas de consumo. Nota-se ainda que o discurso do bem-estar e da felicidade utiliza a publicidade para incentivar os leitores a comprar as novidades lan?adas pela sociedade de consumo
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Senatore, Paula Marchini. "Tramas de Dionísio e Apolo na Antropologia da Face Gloriosa, de Arthur Omar." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/284532.

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Анотація:
Orientador: Etienne Ghislain Samain
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Artes
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Gloriosa, de Arthur Omar, que nos apresenta 161 imagens de rostos brasileiros em situação de êxtase carnavalesco, as quais correspondem a um projeto muito particular de execução de uma nova ciência, marcada por uma forte presença do sujeito. Tal presença é visível no método bastante subjetivo de criação dessa antropologia, que satura não apenas a imagem quanto o discurso. Para entender os procedimentos de composição dessa proposição estético-científica, estudam-se, primeiramente, conceitos relativos à percepção dionisíaca do mundo e sua relação com a percepção apolínea e, num segundo momento, conceitos artísticos e antropológicos que se relacionam com o carnaval enquanto manifestação estética e cultural. Esse percurso teórico ampara a interpretação de que a matéria discursiva e fotográfica é moldada em harmonia com relação ao aspecto temático abordado na Antropologia da Face Gloriosa, em que Apolo e Dionísio tramam, entre luz e sombras, a expressão do ethos brasileiro
Abstract: The aim of this research is to make an interpretation of the book Anthropology of the Glorious Face, written by Arthur Omar. This book presents 161 images of faces in a situation of Brazilian Carnival Ecstasy, which correspond to a very special project for the implementation of a new science, marked by a strong presence of the subjectivity. Such a presence is visible in the method of creating this very subjective anthropology, which saturates the image and the discourse. To understand the compositional procedures of this aesthetic-scientific method, it will be studied Dionysian concepts related to the perception of the world and its relation to Apollonian concepts. It will be studied as well artistic and anthropological concepts that are related to the carnival as a cultural and aesthetic expression. This theoretical path supports the interpretation that the image and the discourse levels are made in harmony with the thematic aspect addressed in the Anthropology of the Glorious Face, in which Apollo and Dionysus plot, between light and shadows, the expression of brazilian ethos
Mestrado
Multimeios
Mestra em Multimeios
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Rivera, Meléndez Alex Axel. "La tensión esencial: Apolo y Dioniso como un contraste entre filosofía y poesía." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/110399.

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Cuando se dedican unas líneas para hablar de Grecia, de sus personajes, disciplinas, historia, etc. surgen dos tipos de interlocutores, aquellos que ven maravillados aquella antigua civilización, que gustosos vuelven la vista hacía esos autores, no solamente por un interés personal, sino también por la relevancia que poseen los griegos como la figura materna que hereda gran parte de lo que la humanidad ha llegado a ser. Por otra parte, están aquellos cuya falta de interés por los griegos, ya sea por su lejanía, su estilo o cualquier otro motivo, rechazan cualquier texto con éste tipo de aroma. Es respetable desde luego, la discordancia para con ciertos autores y ciertos temas, pero el rechazo radical que surge únicamente porque un océano de tiempo nos separa de algunos de ellos, pareciese más una excusa que propiamente un motivo para evitar su lectura. Existen aún montones de sofistas, platónicos, parmenídeos, atomistas, amantes de la épica y la tragedia, y se menciona esto porque consecuentemente al rechazo se sigue el pedir la superación de los griegos.
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Kabore, Nongodo Firmin. "Analyse épidémio-génétique de la fonction rénale chez les personnes d’Afrique sub-Saharienne vivant avec le VIH." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT070.

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Près de 500 millions de personnes dans le monde souffrent de maladies rénales chroniques (MRC) et environ 80% d’entre eux résident dans des pays à revenu faible ou intermédiaire. Les personnes vivant avec le VIH (PVVIH) sont exposées à un risque rénal accru en particulier en Afrique sub-Saharienne. Cette situation est probablement liée à une susceptibilité génétique conférée par des variants du gène de l’apolipoprotéine L1 (APOL1). Ces variants, dont la fréquence est élevée en Afrique et en particulier en Afrique de l’Ouest, ont été identifiés comme fortement impliqués dans la survenue de pathologies rénales graves rencontrées chez les PVVIH.Ce travail de thèse avait pour objectif d’améliorer les connaissances sur l’évolution à long terme de la fonction rénale chez des PVVIH d’Afrique subsaharienne traités contre l’infection à VIH et sur le risque de complications rénales associé aux variants génétiques de APOL1. Nous avons analysé les données médicales et génétiques de plusieurs cohortes de PVVIH suivies dans différentes structures sanitaires d’Afrique de l’Ouest et du Centre.Les prévalences et incidences de la MRC observées dans les différentes cohortes et estimées selon les recommandations du Kidney Disease Outcomes Quality Initiative sont faibles à modérées et contrastent avec les observations faites dans certains pays de la région avec des prévalences atteignant 30%.Les fréquences des 2 variants à risque du gène APOL1 sont également plus faibles qu’attendues, avec seulement 3 à 5% de porteurs du génotype à haut risque. L’observation de fréquences plus élevées en Afrique de l’Ouest qu’en Afrique Centrale est cependant confirmée.En raison du faible nombre de porteurs du génotype à haut risque et des faibles prévalences de MRC, nous n’avons pas pu mettre en évidence un effet significatif des variants de APOL1 sur le risque de complications rénales.En revanche, nos travaux confirment le rôle des facteurs de risque connus tels que l’âge, l’immunodépression, l’hypertension artérielle et l’exposition au Ténofovir Disoproxil Fumarate. Et ces observations nous ont conduits à évaluer les performances d’un score prédictif de la MRC initialement développé pour les PVVIH occidentaux. Nous montrons qu’il peut être utilisé en Afrique sub-saharienne pour identifier les personnes à risque de développer une MRC et leur proposer un suivi et une prise en charge adaptés.Ces travaux apportent des éléments rassurants quant à la santé rénale des PVVIH d’Afrique de l’Ouest suivis et traités pour leur infection VIH. Cependant, au regard des difficultés de prise en charge des maladies rénales sévères, la mise en place de stratégies de dépistage et de prévention doit constituer une priorité de santé publique
Nearly 500 million people worldwide suffer from chronic kidney disease (CKD) and about 80% of them live in low- and middle-income countries. Paeople living with HIV (PLHIV) are at increased risk of renal disease, particularly in sub-Saharan Africa. This situation is probably related to genetic susceptibility conferred by variants of the apolipoprotein L1 gene (APOL1). These variant highly prevalent in Africa, and particularly in West Africa, have been identified as being strongly implicated in the occurrence of serious renal diseases experienced by PLHIV.The aim of this thesis was to provide data about the long-term evolution of renal function in sub-Saharan African PLHIV treated for HIV infection and assess the risk of kidney complications associated with APOL1. We analyzed the medical and genetic data of several cohorts of PLHIV followed in different health care facilities in West and Central Africa.The prevalence and incidence of CKD in the different cohorts and estimated according to the recommendations of the Kidney Disease Outcomes Quality Initiative are low to moderate and contrast with the observations made in some countries of the region with prevalence reaching 30%.The frequencies of the 2 risk variants of the APOL1 gene are also lower than expected, with only 3 to 5% of carriers of the high-risk genotype. The observation of higher frequencies in West Africa than in Central Africa is, however, confirmed.Due to the low number of carriers of the high-risk genotype and the low prevalence of CKD, we were unable to demonstrate a significant effect of APOL1 variants on the risk of kidney complications.However, our work confirms the role of other risk factors such as age, immunosuppression, hypertension and Tenofovir Disoproxil Fumarate exposure. These observations led us to evaluate the performance of a prediction score of CKD initially developed for Western PLHIV. We show that this score can be used in sub-Saharan Africa to identify people at risk of developing a CKD and provide them with targeted monitoring and prevention intervention.These findings provide reassuring information about the evolution of renal function in West African PLHIV followed and treated for their HIV infection. However, given that management of severe kidney disease is a major challenge is these settings, the implementation of screening and prevention strategies must be a public health priority
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Castro, Carlos Potiara. "O encontro de Apolo com a floresta : ciencias sociais, ocidentalização do mundo e Amazonia." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/280510.

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Анотація:
Orientador: Leila da Costa Ferreira
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas
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Resumo: Este trabalho porta sobre a produção intelectual elaborada sobre a região amazônica na área de ciências sociais em três países: Brasil, Colômbia e Equador. Para realizar esse objetivo é feita uma discussão sobre o processo de transformação da região. É argüido que se trata de um processo que se repetiu ao longo do tempo em outras regiões do globo e que não se constitui em um movimento único na história, a não ser pelas especificidades locais. A própria irracionalidade desse avanço, que constitui e define em grande parte o objeto de estudo dessas ciências sociais, ou ao menos a tensão central em torno da qual é elaborada, é reveladora dos limites, das franjas de possibilidades reais que se colocam diante de nossa sociedade. Concluímos que trabalhar esse tema, os estudos amazônicos, dos de maior envergadura para a área ambiental, pode levar a entrever não apenas problemas presentes na região de maior floresta tropical do mundo. De uma forma especial esse tema nos habilita também a discutir a atual crise industrial, política e social traduzida pelo que chamamos de dilema ambiental. Palavras-chave: Ciência e tecnologia ¿ Amazônia; Pós-colonialismo; Produção científica ¿ Brasil; Produção científica ¿ Colômbia; Produção científica ¿ Equador; Ciências Sociais
Abstract: This work deals with the scientific literature about the Amazon region produced in the field of social sciences in three different countries: Brazil, Colombia and Ecuador. To achieve this goal we make a prior discussion about the transformation of the region related to the advancement of our civilization on its territory. It¿s argued that this is a process that was repeated over the time in other regions of the world and that this is not a unique movement in history even if with local specificities. The irrationality of this process, that defines in large part the study object of this literature, or at least the tension around it¿s center, reveals the limits of our contemporary societies. We conclude that working with that subject can uncover not only problems in the region of the world's largest tropical rainforest, but it enables us also to discuss the current industrial, political and social crisis translated by the concept of environmental dilemma. Keywords: Science and technology ¿ Amazon; Post-colonialism ; Scientific Production ¿ Brazil; Scientific Production ¿ Colombia; Scientific Production ¿ Ecuador ; Social Sciences
Doutorado
Doutor em Ciências Sociais
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Книги з теми "ApoL9"

1

Robison, Ken. Apolo Ohno. Greensboro, N.C: Morgan Reynolds Pub., 2012.

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Dunn, Justine. Apolo 11. Glenview, Illinois: Scott Foresman, 2011.

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Laurel de Apolo. Firenze: Alinea, 2002.

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Alas, Leopoldo. Apolo en Pafos. Almería: Seminario Fin de Siglo y Formas de la Modernidad, Instituto de Estudios Almerienses, 1988.

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5

Perdomo, Apolinar. Cantos de Apolo. 2nd ed. [Dominican Republic: s.n.], 1986.

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6

ill, Moreiro Enrique S., ed. Cuentos de Apolo. New York, NY: Lectorum Publications, 1999.

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7

J, Sedeño Francisco, ed. Flor de Apolo. Kassel: Edition Reichenberger, 2005.

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Aldridge, Rebecca. Apolo Anton Ohno. New York: Chelsea House, 2009.

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9

Antonio, Carreño, ed. Laurel de Apolo. Madrid: Cátedra, 2007.

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Uschan, Michael V. Apolo Anton Ohno. Detroit [Mich.]: Lucent Books, 2011.

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Частини книг з теми "ApoL9"

1

Cillo, Umberto. "APOLT and RAPID Techniques." In Liver Transplantation and Hepatobiliary Surgery, 167–74. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-19762-9_17.

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Schlitt, H. J. "Auxiliäre partielle orthotope Lebertransplantation (APOLT) bei fulminantem Leberversagen." In Deutsche Gesellschaft für Chirurgie, 254–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59573-8_103.

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Palmes, D., and H. U. Spiegel. "Auxiliäre partielle orthotope Lebertransplantation (APOLT) an der Ratte." In Bilanz zur Jahrtausendwende, 1319. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-60248-1_345.

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4

Murguia-Favela, Luis. "APOL-1 Variants, Susceptibility and Resistance to Trypanosomiasis." In Encyclopedia of Medical Immunology, 19–23. New York, NY: Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4614-8678-7_64.

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Murguia-Favela, Luis. "APOL-1 Variants, Susceptibility and Resistance to Trypanosomiasis." In Encyclopedia of Medical Immunology, 1–5. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-9209-2_64-1.

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Jadach, Stanisław, and Zbigniew Wa̧s. "The Apol as Test of the Standard Model at LEP." In Radiative Corrections for e+e- Collisions, 129–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74925-4_8.

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Palmes, D., H. Freise, H. Herbst, and H. U. Spiegel. "Auxiliäre partielle orthotope Lebertransplantation (APOLT) als Therapie des akuten Leberversagens an der Ratte." In Deutsche Gesellschaft für Chirurgie, 289–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57295-1_61.

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Godart, Simon. "Gewalt und Entzug: Apoll und Daphne; Jupiter, Juno und Callisto; Hippomenes und Atalante." In Ovid-Handbuch, 359–64. Stuttgart: J.B. Metzler, 2021. http://dx.doi.org/10.1007/978-3-476-05685-6_56.

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Maniu, Nicholas. "III.1.5 Apoll und Marsyas: Im Spannungsfeld zwischen apollinischem ›Ideal‹ und dionysischem Exzess." In Queere Männlichkeiten, 163–79. Bielefeld, Germany: transcript Verlag, 2023. http://dx.doi.org/10.14361/9783839467381-007.

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Palmes, Daniel, K. H. Dietl, T. Budny, S. Skawran, H. Herbst, and H. U. Spiegel. "Bedeutung der Transplantatrearterialisierung nach auxiliärer partieller orthotoper Lebertransplantation (APOLT) in der Therapie des akuten Leberversagens." In Chirurgisches Forum 2002, 329–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56158-0_84.

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Тези доповідей конференцій з теми "ApoL9"

1

Chau, Duen Horng, Aniket Kittur, Jason I. Hong, and Christos Faloutsos. "Apolo." In the 2011 annual conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/1978942.1978967.

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Chau, Duen Horng, Aniket Kittur, Jason I. Hong, and Christos Faloutsos. "Apolo." In the 17th ACM SIGKDD international conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2020408.2020524.

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Kulikov, Mikhail, Victor Fimushkin, Roman Kuzyakin, Yuriy Prokofichev, and Alexey Shumkov. "Absolute polarimeter APol for NICA collider project." In 23rd International Spin Physics Symposium. Trieste, Italy: Sissa Medialab, 2019. http://dx.doi.org/10.22323/1.346.0149.

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Pimentel, Antonio Marcos Gonçalves. "Apolo e Daphne de Bernini: verossimilhança da literatura mitológica latina na escultura barroca." In Encontro da História da Arte. Universidade Estadual de Campinas, 2008. http://dx.doi.org/10.20396/eha.4.2008.3998.

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Анотація:
O Mito de Apolo e Daphne é um dos mais recorrentes em toda a Antiguidade e também um dos que apresentam várias versões. Em todas elas, o ponto em comum é a fuga de Daphne das investidas amorosas de Apolo, culminando com a sua transformação em Loureiro. É esse o momento que Bernin imortaliza em sua escultura, que compõe o grupo borghesiano integrando o conjunto que retoma uma série de narrativas míticas. Influenciada pela cultura helenística e pelas estátuas desse período do qual faz parte o laocoonte, a estátua de Bernini se caracteriza pelo movimento espiralado e pelo dramatismo da cena representada, típico da representação desse período que valorizava o ápice da ação, seu clímax. O momento em que todo o drama se revela conferindo um ar teatral à cena. Além disso, deve-se notar o extremo realismo com que essas obras foram dotadas: as texturas das carnes, a riqueza de detalhes e a construção dos rostos. Nesta comunicação, pretendemos fazer um cotejo entre a descrição do mito de Apolo e Daphne descrito na literatura latina nas Metamorfoses, de Ovídio, através da análise profunda do léxico latino utilizado por esse autor, relacionando-a com os detalhes escultóricos de Bernini. Embora a questão da mimesis permeie nosso cotejo literário-escultural, seja ela considerada pelo lado platônico ou aristotélico, a questão artística, considerando-se também a questão da presença ou não da imitatio latina, já se constitui numa realidade: a verossimilhança inter artes, a literatura e a escultura. É essa verossimilhança que pretendemos analisar e discutir até que ponto a escultura de Bernini foi fiel ao texto latino, ou se fez dele apenas um ponto de partido, preservando apenas, senão o texto, a emoção do momento que este conseguiu imprimir em suas linhas.
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Marioara, Costea. "GEOMORPHOLOGICAL CONDITIONS OF GULLYING IN APOLD DEPRESSION (CENTRAL ROMANIA)." In 17th International Multidisciplinary Scientific GeoConference SGEM2017. Stef92 Technology, 2017. http://dx.doi.org/10.5593/sgem2017/32/s13.035.

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Liu, Wei, Jeffrey Weaver, Lucas Weaver, Terry Whelan, Rajive Bagrodia, Pedro A. Forero, and Jose Chavez. "APOLL: Adaptive Polling for Reconfigurable Underwater Data Collection Systems." In 2018 OCEANS - MTS/IEEE Kobe Techno-Ocean (OTO). IEEE, 2018. http://dx.doi.org/10.1109/oceanskobe.2018.8559219.

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Akabane, Ademar T., Rafael L. Gomes, Richard W. Pazzi, Edmundo R. M. Madeira, and Leandro A. Villas. "APOLO: A Mobility Pattern Analysis Approach to Improve Urban Mobility." In 2017 IEEE Global Communications Conference (GLOBECOM 2017). IEEE, 2017. http://dx.doi.org/10.1109/glocom.2017.8253942.

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Bousselet, P., H. Bissessur, P. Brindel, E. Dutisseuil, I. Brylski, and D. Mongardien. "Record 505 km unrepeatered 4x43Gb/s APol-RZ-DPSK transmission." In 2008 34th European Conference on Optical Communication. IEEE, 2008. http://dx.doi.org/10.1109/ecoc.2008.4729164.

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he, zhou, yi di, zheng wang, binghua shi, and wei xu. "160Gbit/s Apol-FSK modulation format for 5G backhaul network." In 13th International Photonics and OptoElectronics Meetings (POEM 2021), edited by Xinliang Zhang, Perry Shum, and Jianji Dong. SPIE, 2022. http://dx.doi.org/10.1117/12.2626566.

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Franz, Bernd, Gabriel Charlet, and Axel Klekamp. "Performance improvement of 43 Gbit/s Apol-RZ-DPSK transmission by electronic equalization." In 2008 34th European Conference on Optical Communication. IEEE, 2008. http://dx.doi.org/10.1109/ecoc.2008.4729482.

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