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Добірка наукової літератури з теми "Analytical clinic"

Автор: Grafiati

Опубліковано: 13 квітня 2024

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Статті в журналах з теми "Analytical clinic"

Lindon, J. C. "NMR spectroscopy: Analytical applications from chemistry to the clinic." Journal of Pharmaceutical and Biomedical Analysis 4, no. 2 (January 1986): 137–45. http://dx.doi.org/10.1016/0731-7085(86)80035-8.

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Smiraglia, Richard. "The Domain Analysis Clinic." Brazilian Journal of Information Science: research trends 16 (December 16, 2022): e02160. http://dx.doi.org/10.36311/1981-1640.2022.v16.e02160.

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Domain analysis is a primary approach to the representation of shared ontological bases in knowledge organization. The growth of domain analysis as a paradigm is demonstrated over a period of two decades. The Domain Analysis Clinic, or DAC is a core methodology generated for focused concept discovery combining meta-analytical theoretical research with the formation of domain-specific knowledge organization systems. The emergence of the DAC as a tool for meta-analysis and discourse analysis has demonstrated the efficacy of focused concept formation for taxonomic representation as well as for theoretical discovery in KO. The evidence presented here strongly directly suggests the continued honing and maturity of domain analysis as a paradigm in KO.

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Trisnawati, Risca, Fathorrahman, and Theresia Pradiani. "Pengaruh Kualitas Pelayanan, Fasilitas dan Brand Image Terhadap Kepuasan Pasien Di Klinik RH Medica Malang." Bursa : Jurnal Ekonomi dan Bisnis 2, no. 1 (January 12, 2023): 70–79. http://dx.doi.org/10.59086/jeb.v2i1.234.

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Outpatient clinics in Indonesia, especially in Malang, continue to increase, one of the clinic services that is starting to develop is beauty. Looking beautiful and attractive is a need that always exists in every human being, especially women. The need to perform facial and body care to make it beautiful has had many positive impacts on the growth and development of clinics, one of which is RH Medica clinic in Malang. The purpose of this research is to analyze the effect of service quality, facility, brand image on patient satisfaction at RH Medica clinic. The subjects in this study were patients who visited, bought and used products/treatments with a sample of 98 respondents. Data collection techniques using a questionnaire. The analytical method used was descriptive analysis using non-probability techniques with purposive sampling, SPSS analysis method. using non-probability techniques with purposive sampling, SPSS analysis method. The results of this study show that service quality, facilities and brand image have a positive and significant effect on patient satisfaction at the RH Medica clinic. Simultaneously service quality, facilities and brand image have a significant effect on patient satisfaction at the RH Medica clinic, and patient satisfaction can be explained by the service quality, facilities and brand image variables of 68.4% while the rest is explained by other variables not present in this study.

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Finlayson, Duncan, Christopher Rinaldi, and Matthew J. Baker. "Is Infrared Spectroscopy Ready for the Clinic?" Analytical Chemistry 91, no. 19 (September 10, 2019): 12117–28. http://dx.doi.org/10.1021/acs.analchem.9b02280.

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John, W. G., R. Edwards, and C. P. Price. "Laboratory Evaluation of the DCA 2000 Clinic HbA1c Immunoassay Analyser." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 31, no. 4 (July 1994): 367–70. http://dx.doi.org/10.1177/000456329403100411.

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The DCA 2000™ clinical analyser for the measurement of haemoglobin A1c was evaluated for analytical quality. The analyser, which utilises inhibition of latex agglutination immunoassay, demonstrated good within-batch (1 · 9–3 · 1% CV) and between-batch (2·2% CV) imprecision, and was not affected by haemoglobin concentration. The analyser was linear throughout the analytical range, and was found to correlate well with agar electroendosmosis ( r = 0·93), affinity chromatography ( r=0·97), HPLC ( r=0 · 90) and EIA ( r=0·98). The analyser was found to give reliable analytical results, and with its ease of use, will provide the diabetologist with HbA1c results in the clinic; although an analysis time of 9 min will limit sample throughput.

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Alchusnah, Retno Hayati, Dewi Sarastuti, Lia Fetti Hidayati, Fatimah Septiantari, and Belladina Yusi Lasara. "The effectiveness of using local exhaust ventilation, HEPA filter, and dental aerosol suction on indoor air quality." Padjadjaran Journal of Dentistry 35, no. 1 (April 1, 2023): 23. http://dx.doi.org/10.24198/pjd.vol35no1.33566.

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ABSTRACTIntroduction: The emergence of COVID-19 pandemic that occurred at the end of December 2019 in Wuhan, China, was a health crisis that greatly affected the world. Therefore, dentists and dental nurses are professionals who have a very high risk of being exposed to the droplets and aerosol particles generated during dental procedures. Furthermore, they also have a high risk of cross-infection from exposure to microorganisms in blood, saliva, droplets, and instruments contaminated with blood, saliva, and tissue debris. This study aims to analyze the effectiveness of using exhaust fan wall/Local Exhaust Ventilation (LEV), HEPA filter, and dental aerosol suction in the dental clinic of Academic Hospital Gadjah Mada University. Methods: The type of the research is analytical observational study. This study measured temperature, humidity, ACH and the microbial load in the 3 dental clinic rooms of Sadewa 1 RSA UGM in September 2020, using an analytical observational method with ANOVA to determine the effect of using a LEV, HEPA filter and dental aerosol suction in the dental clinic. Results: Dental clinic equipped with a LEV, HEPA filter, and dental aerosol suction, was negatively associated with room humidity levels, with a Pearson correlation of (-0.777), air humidity correlated with microbial load (0.242), but the correlation was not large. From the ANOVA results, the use of LEV, HEPA filter and dental aerosol suction against humidity has a significant effect on reducing the humidity in the dental clinic with p value 0.05. Conclusion: The use of an oral LEV, HEPA filter, and dental aerosol suction has an effect on reducing air humidity and decreasing the microbial load, affects the number of particles or droplets in dental clinics, and affects ACH.Keywords: local exhaust ventilation, HEPA filter and dental aerosol suction, microbial load, humidity

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Indriya Himawan, Abdurrahman Faris. "ANALYTICAL HIERARCHY PROCESS SEBAGAI EVALUASI SUPPLIER ALAT KESEHATAN DAN OBAT – OBATAN DI RUMAH SAKIT MUHAMMADIYAH." MANAJERIAL 6, no. 01 (April 27, 2019): 35. http://dx.doi.org/10.30587/jurnalmanajerial.v6i01.859.

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Supplier selection is one of the important things in purchasing activities for companies, because the selection of suppliers is very influential on the quality of a product. One way to choose the right supplier for the company can be done using the Analytical Hierarchy Process (AHP) method, the Analytical Hierrarchy Process method is a decision-making method developed to give priority to several alternatives when several criteria must be considered. Some things to consider in choosing suppliers such as: shipping, quality, service, past performance, payment. This research was conducted at one of Muhammadiyah's charitable businesses, namely at the Muhammadiyah Hospital or Clinic. This study aims to find out the best supplier for Muhammadiyah Hospital. This study uses a quantitative descriptive research approach. With the use of samples from this study is the decision making in the purchase of drugs and medical devices Clinic or Muhammadiyah Hospital. The results of the data analysis concluded that the indicators of quality, acceleration of service, credibility of suppliers are bets in determining the best suppliers for the procurement of drugs and medical devices clinics or hospitals Muhammadiyah. Whereas from the overall simulation results Supplier Q is considered as the best supplier for Muhammadiyah Hospital, because overall of all criteria Supplier Q has the highest value compared to other suppliers.

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Aljameeli, Abdulrahman Mohammed. "The Impact of Virtual Clinic on the Services` Users during Corona Virus Pandemic (COVID-19) in Health Care Centers in Riyadh, Saudi Arabia." Asian Journal of Medicine and Health 21, no. 12 (December 18, 2023): 30–46. http://dx.doi.org/10.9734/ajmah/2023/v21i12958.

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This study aimed to assess the impact of virtual clinic on the services'` users during the Corona Virus (COVID-19) pandemic in health care centers in Riyadh. The researcher used the descriptive analytical method, and the study sample consisted of 100 individuals who used services in health care centers in Riyadh. The researcher used the SPSS statistical package program. The researcher reached to several results, the most important of which are; virtual clinics are very effective in improving the delivery of user services. Most of study subjects are fully treated despite not being seen in person. More than two thirds of the study sample 68% consider that the length of time spent with the therapist or one of his family members is a good period. The treatment was explained by the virtual clinic staff to a very good degree (67%). The degree of accuracy, care and skill of the virtual clinic staff is high (69%). Courtesy, respect, sensitivity and friendliness are provided by the virtual clinic staff at an excellent rate of 88%. The virtual clinic staff is distinguished by a very high respect for patient privacy (88%). The staff responds to the patient's questions about the treatment plan effectively and to a high degree (99%). The degree of the comprehensive treatment experience of the study sample using a virtual clinic is very good and excellent (81%). The researcher also concluded several recommendations, including; - Providing adequate time for health care users by health care providers.

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Flatland, Bente, Liesl C. Breickner, and Michael M. Fry. "Analytical performance of a dry chemistry analyzer designed for in-clinic use." Veterinary Clinical Pathology 43, no. 2 (March 3, 2014): 206–17. http://dx.doi.org/10.1111/vcp.12122.

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Більше джерел

Дисертації з теми "Analytical clinic"

Faure, Nathalie. "La pulsion olfactive - intérêts et perspectives : Pour une prise en compte de l'odeur dans la métapsychologie analytique." Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://www.theses.fr/2023COAZ2019.

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Bien que l'odorat soit étudié dans les disciplines relevant des sciences humaines, il semblerait qu'en psychologie clinique d'orientation analytique nous soyons confrontés au peu de recherches effectuées sur cette thématique. Il existe quelques références dans le Moi-peau (Anzieu, 1995), ou dans le travail de Tristani (1978) qui propose de concevoir un stade de la construction psychique fondé sur l'action de respirer, mais il ne fait que survoler l'importance de l'odeur dans ce stade. Nous nous sommes donc demandés si l'odeur a une place dans notre construction psychique, avec l'hypothèse qu'il existe une pulsion olfactive qui participe à l'organisation du sujet. Pour répondre à la problématique introductive, notre première partie présentera une revue de littérature spécifique, axée sur la littérature analytique. Nous commencerons par évoquer les recherches de Freud et Fliess sur le lien entre odorat et hystérie. Nous poursuivrons avec le travail de Lacan concernant notre sujet. Cette partie se poursuivra par une réflexion sur l'apport de la psychologie du développement. Il s'agira ici de confronter nos idées aux expériences et de discuter d'un possible trajet pulsionnel. La deuxième partie de cette thèse se penchera sur les critères de la pulsion chez Freud, Irme Hermann et Jacques Lacan. La troisième partie, sera consacrée à un modèle théorique de la pulsion olfactive
Although the sense of smell is studied in the disciplines of the human sciences, it would seem that in psychology of analytical orientation, we are confronted with the little research carried out on this topic. There are a few references in the Skin-ego (Anzieu, 1995), or in the work of Tristani (1978) who proposes to conceive a stage of psychic construction based on the action of breathing, but he only hovers over the importance of odor in this stage. We therefore asked ourselves whether the smell has a place in our psychic construction, with the main hypothesis that there is an olfactory drive that participates in the organization of the subject. To answer the introductory problem, our first part will present a specific analytic literature review. We will begin by evoking the research of Freud and Fliess on the link between smell and hysteria. We will continue with the work of Lacan concerning our subject and a reflection on the contribution of developmental psychology. It will be discussing a possible drive circuit. The second part of this thesis will look at the criteria of the drive in Freud, Hermann and Lacan drive theory. The third part are a theoretical model of the olfactory drive

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Safari, Leila. "A clinical data analytics language (CliniDAL)." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12858.

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This work aims to propose CliniDAL as a generic solution for a special purpose query language for Clinical Data Analytics, which can compute answers to any question that is answerable from a Clinical Information System (CIS), with a specific focus on addressing temporal issues in CISs. The research begins with the investigation of common questions in the clinical domain, which led to the definition of 6 classes of question and answer categories. A set of syntactic rules has been generated to support these query categories which enables direct question answering and supports answering research-oriented queries requiring data analytics functionalities. Also, a framework is proposed for scientific experimentation which resolves time-event dependencies in the queries. A free text search facility for string searching and semantic concept searching (using SNOMED-CT) is provided to enhance the results. In addition, a temporal model is proposed and integrated into CliniDAL which enables the use of natural language temporal expressions in query composition. A generic mapping algorithm is proposed using a similarity based top-k algorithm (accuracy of more than 84%), which automatically maps the query terms to the underlying data or schema of CISs with design models of ER, EAV or hybrid models of ER and EAV. Also, a generic translation algorithm is proposed to translate an initial text query to a set of SQL queries, mainly to resolve complexity of data extraction from CISs with an EAV model. The experimental results based on testing more than 270 clinical queries and 4 case studies reflect the capability of the language at creating the desired queries via the restricted natural language of the provided web-interface. So, it is not only much easier for naïve database users like clinicians to apply CliniDAL’s approach in comparison to an SQL approach, but also they do not need to have any knowledge of data or schema of the underlying CIS for the composition of queries.

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NUNES, GABRIEL CUNHA. "THE CLINIC OF TRAUMA AND THE REGRESSIVE STATES IN THE ANALYTIC SETTING." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2018. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34242@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
FUNDAÇÃO DE APOIO À PESQUISA DO ESTADO DO RIO DE JANEIRO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
BOLSA NOTA 10
O presente trabalho tem como objetivo investigar o conceito de trauma na psicanálise, bem como a regressão terapêutica como via de elaboração do evento traumático não representado psiquicamente a partir da situação analítica. Para isso, na primeira parte deste trabalho, analisaremos a noção de trauma a partir da perspectiva de Sándor Ferenczi, considerando o percurso teórico do autor que lhe permitiu formular a ideia do trauma constituído em dois tempos, a partir de uma confusão de línguas. Na segunda parte, acompanharemos os desdobramentos diretos e indiretos dessa teoria na Escola Inglesa de Psicanálise, representada por dois autores pertencentes ao grupo independente: Donald W. Winnicott e Michael Balint. Exploraremos então o funcionamento psíquico primitivo do indivíduo e o papel exercido pelo ambiente na constituição subjetiva, assim como as intensas falhas ambientais e as funções patogênicas das mesmas, ou seja, as repercussões do trauma como um evento catastrófico que interrompe o desenvolvimento emocional. Na terceira parte, adentraremos uma discussão clínica, reconhecendo as bases que constituem o setting analítico, compreendendo os diferentes usos das interpretações e as manifestações clínicas da regressão como uma nova chance de liquidação e elaboração do material traumático. Por fim, realizaremos um exame sobre as propostas da psicanálise contemporânea a partir das ideias da psicanálise do colapso, de Christopher Bollas; do terceiro analítico, de Thomas H. Ogden; e da empatia psicanalítica, de Stefano Bolognini, mostrando novas concepções a respeito da clínica do trauma e do manejo de casos regressivos no pensamento psicanalítico atual.
The present work aims to investigate the concept of trauma in psychoanalysis, as well as therapeutic regression as a way to elaborate the unrepresentable traumatic event through the analytical situation. To achieve this goal, on the first part of this work, we will analyze the notion of trauma from Sándor Ferenczi s perspective, considering the theoretical course that allowed him to formulate de idea of a trauma constituted in two times, from a confusion of tongues. On the second part, we will follow the direct and indirect unfolding of this theory in the English School of Psychoanalysis, represented by two authors belonging to the independent group: Donald W. Winnicott and Michael Balint. We shall explore then the primitive psychic functioning of the individual and the role played by the environment on the subjective constitution, as well as the severe environmental flaws and their pathogenic functions, i. e. the repercussions of the trauma understood as a catastrophic event that disrupts the emotional development. On the third part we will enter a clinical discussion, recognizing the principles that shape the analytical setting, comprehending the different uses of interpretations and the clinical manifestations of regression as a new opportunity to liquidate and elaborate the traumatic material. Lastly we shall examine the contemporary psychoanalysis suggestions over the ideas of the psychoanalysis of breakdown, by Christopher Bollas; the analytic third, by Thomas H. Ogden; and the psychoanalytic empathy, by Stefano Bolognini, show new concepts over the clinic of trauma and about how to handle regressive cases in the current psychoanalytic thought.

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Barve, Chinmayee. "Individual factors as buffers against parental expressed emotion : a path-analytical model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0006/MQ44124.pdf.

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Busson, Laurent. "Evolution of direct diagnostic techniques in Virology; analytical performances and clinical input." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/313391.

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Le diagnostic virologique est un sujet d’actualité particulièrement du fait des récentes épidémiesou pandémies telles que la pandémie d’influenza A(H1N1) en 2009 ou la diffusion du virus Zika dansles Amériques et la région du Pacifique entre 2014 et 2017, associée à des cas de microcéphalie et dessyndromes de Guillain Barré. Encore plus récemment, en août 2018, le ministre de la santé de laRépublique Démocratique du Congo annonçait la 10e épidémie de virus Ebola dans le pays et endécembre 2019, le coronavirus SARS-CoV-2 est à l’origine d’une pandémie au départ de la Chine. Avecle nombre croissant de migrants et de voyageurs favorisant la dissémination des maladies virales, leslaboratoires diagnostiques doivent être parés à la fois pour l’identification des virus communs maisaussi de ceux importés.Les techniques les plus anciennes de diagnostic virologique tendent à devenir obsolètes suite audéveloppement rapide des techniques moléculaires depuis les années 90. Cependant, nous utilisonstoujours un mélange de techniques moléculaires et non moléculaires au sein de notre laboratoire.Les objectifs de ce travail sont de passer en revue les différentes techniques communémentutilisées pour la détection directe des virus avec leurs avantages et leurs inconvénients et de fournirune réflexion sur la place de chaque technique, en 2020, dans un laboratoire diagnostique.Nous aborderons tout d’abord les cultures cellulaires et nous insisterons sur leur polyvalence quipermet parfois de mettre en évidence des micro-organismes que l’on ne suspectait pas. Nousillustrerons ce point par un article relatant la mise en évidence de Chlamydia trachomatis du serovar Lresponsables de la lymphogranulomatose vénérienne dans des prélèvements envoyés pour suspiciond’infection herpétique.Le travail se focalisera ensuite plus particulièrement sur le diagnostic des infections viralesrespiratoires. Nous verrons les principes des tests de détection antigéniques et discuterons de leurslimites en se basant sur un article qui traite du diagnostic des virus influenza A et B par 3 différentstests immunochromatographiques. Cet article montre que la sensibilité des tests varie en fonction dela charge virale dans le prélèvement ainsi que du sous-type de virus.Nous poursuivrons avec les tests d’amplification d’acides nucléiques (tests moléculaires) enexpliquant la technique de PCR (Polymerase Chain Reaction) et une technique d’amplificationisothermique (Nicking Enzyme Amplification Reaction - NEAR). Nous illustrerons par un article portantsur l’évaluation du test Alere i influenza A&B (technique NEAR) en comparaison du test Sofia influenzaA+B (immunochromatographie). Cet article montre un gain de sensibilité de l’Alere i par rapport auSofia pour le diagnostic de l’influenza A mais pas pour l’influenza B. Il constitue également un travailpréliminaire sur l’appréciation de l’utilité d’une technique PCR rapide dans la prise en charge despatients. La conclusion est qu’il pourrait y avoir un apport de ce type de technique pour la diminutiondes hospitalisations, de la prescription des examens complémentaires et des antibiotiques. Celapermettrait également une prescription plus adéquate de l’oseltamivir pour le traitement de la grippe.Le point important est que l’impact du résultat est d’autant plus grand qu’il est délivré précocementdans la prise en charge des patients, idéalement lorsqu’ils sont encore aux urgences.Suite au travail sur l’Alere i, nous avons entrepris d’évaluer un test PCR multiplex (FilmArrayRespiratory Panel) pour le diagnostic des virus afin de voir si la détection d’un plus grand nombre depathogènes pourrait avoir un impact plus grand sur la prise en charge des patients. Cette évaluation adonné lieu à deux articles. Le premier détaille les avantages et inconvénients des différents outils dediagnostic pour la détection des virus respiratoires et sert d’état des lieux sur les tests utilisésactuellement dans les laboratoires de virologie. Le deuxième article porte plus particulièrement surl’apport du FilmArray dans la prise en charge des patients. La conclusion est que ce n’est pas le résultatdu test qui a un impact sur cette prise en charge mais plutôt d’autres facteurs notamment l’âge ou desmarqueurs inflammatoires biologiques.Nous terminerons ce travail par un aperçu des techniques de séquençage qui seront sans aucundoute de plus en plus utilisées pour le diagnostic en virologie.
Doctorat en Sciences médicales (Médecine)
info:eu-repo/semantics/nonPublished

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Giori, L. "IDENTIFICATION OF NEW BIOMARKERS AND INNOVATIVE ANALYTICAL METHODS IN VETERINARY CLINICAL PATHOLOGY." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/168079.

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Since laboratory tests are becoming more and more important in the diagnostic process even in the veterinary clinical practice, a specialist, able to manage the quality of the amount of work inside the laboratory itself, becomes a must. The main challenge for the clinical pathologist, when introducing instruments or new methods in the laboratory, is the “validation phase” to ensure that all the results show the real clinical condition of the patient rather than the variable analytical nature of the test itself. Diagnostic test or instrument validation is composed of four steps, including both the evaluation of analytical performances and the actual applicability and utility of the test/instrument in clinical practice. The general purpose of this thesis has been to investigate some methods and instruments, through analytical validation studies regarding one or more of the 4 steps of validation process, for which information about the applicability on animal samples does not exist or is very rare. We have also looked for new molecules/techniques that could improve the performances of the traditional ones, especially considering the potential elements that would improve them. In particular, research activities have been focused to three main objectives, respectively directed to the three more studied macro areas of the clinical pathology: hematology, biochemistry and urinalysis. Specifically, the more extensive analytical and biological validation was focused on paroxonase (PON1) a new and promising acute phase reactant that would act as a fast negative acute phase proteins. Moreover, through two sequential studies, we addressed the first step of the validation process (analytical validation) for quantitative and qualitative evaluation of proteinuria. Other studies were focused on biological validation, in selected clinical conditions, of new hematological parameters provided by laser-based instruments or of biochemical markers. Specifically we validate an instrumental approach that might be a useful preliminary screen for detecting leukemia in dogs; we validate the possible role of high fluorescent fractions of platelets in Norfolk terriers with macrothrombocytopenia; we validate a new “GE” gate to be used in breeds with “grey eosinophils” that are underestimated by traditional instrumental hematological approaches. As regards hematological parameters, the analytes that were already validated by others for which we investigate the biological role in veterinary laboratories were: SAA in foals after strong exercise; AGP in atypical forms of FIP and CK isoenzymes in horses. This thesis demonstrates the importance to maintain and establish rigorous processes of validation both for analytes/methods newly introduced in clinical practice and for analytes/methods that are currently used. Only through this process of analytical and biological validation it is possible to discover novel diagnostic applications of traditional approaches (as for hematological analyzers in our case) but also to define both the advantages and the limitations of traditional diagnostic approaches that could provide unreliable results when applied to selected clinical conditions.

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Sholademi, Benjamin Ayoola. "Identification and reduction of pre-analytical errors in clinical chemistry through expert advice." Thesis, Sheffield Hallam University, 2017. http://shura.shu.ac.uk/16823/.

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Background: Diagnostics in Clinical chemistry laboratory is a pivotal part of clinical decision-making but is not exempt from ‘human errors’. Scientific innovations such as automation and electronic order test requesting have contributed to substantial improvements in the field of laboratory science, but errors still occur. One major example of such failing is connected to the prevalence of errors occurring in pre-analytical phase of the Total Testing Process (TTP). Preanalytical errors can occur at the time of patient assessment, test order entry, patient identification, sample collection, sample transport, or sample receipt in the laboratory. Previous work and clinical insights suggest that most errors in the TTP are extra-laboratory (i.e. they occur before the samples reach the laboratory for analysis). Such errors are frequently the results of human mistakes during phlebotomy practice. Therefore to reduce these errors the pre-analytical phase of the TTP must be prioritised. Study objective: To investigate the sources of pre-analytical errors in the TTP, categorize these errors in order to identify the error prone steps, and evaluate errorreporting frequencies, with the aim of improving service. Methods: The first part of the study was a query of the laboratory information management system (LIMS) for samples rejected due to pre-analytical errors. Data collection was done retrospectively to cover two periods from 2007-2008 (manual paper test requesting) and 2012-2013 (after implementation of electronic test ordering, Anglia-ICE). Pre- and post- implementation Anglia-ICE error data were transferred to excel spreadsheets and compared by chi-squared test. The contribution of each error category to total sample error received in the laboratory was also determined. The second part of the study was a questionnaire survey of pre-analytical procedures to capture the attitudes of phlebotomists towards current practice in Sheffield Teaching Hospitals NHS Foundation Trust (STH NHS FT). Results: The results of the first part of the study indicated that of the 416,703 specimens collected pre-Anglia ICE, 2,055 (0.49%) were recorded as errors compared with 1,616 errors (0.11%) of 903,814 specimens collected post-Anglia ICE implementation, which represents a 0.31% (p < 0.05) absolute error reduction rate, although more samples were received post-Anglia-ICE. The results of the second part (questionnaire survey) indicate that recommended procedure for phlebotomy practice was not strictly followed by a large percentage of the staff surveyed. Conclusion: This study is the first inquiry linking venous blood sampling (VBS) practices in phlebotomy to retrospective LIMS pre-analytical data in a UK NHS Hospital. The results suggest low compliance by staff with recommended practice, which may be responsible for the prevalence of certain categories of pre-analytical errors in the TTP and may also be associated with increased risks to attending patients. It is suggested that the development of a local guideline for VBS and compliance to this guideline will improve phlebotomy practice, improve the quality of sample testing in the clinical chemistry laboratory, reduce pre-analytical errors in TTP and consequently improve the safety of patients.

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Goodman, Corey William. "Cost effective, computer-aided analytical performance evaluation of chromosomal microarrays for clinical laboratories." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/3301.

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Many disorders found in humans are caused by abnormalities in DNA. Genetic testing of DNA provides a way for clinicians to identify disease-causing mutations in patients. Once patients with potentially disease-causing mutations are identified, they can be enrolled in treatment or preventative programs to improve the patients' long term quality of life. Array-based comparative genomic hybridization (aCGH) provides a high- resolution, genome-wide method for detecting chromosomal abnormalities. Using computer software, chromosome abnormalities, or copy number variations (CNVs) can be identified from aCGH data. The development of a software tool to analyze the performance of CGH microarrays is of great benefit to clinical laboratories. Calibration of parameters used in aCGH software tools can maximize the performance of these arrays in a clinical setting. According to the American College of Medical Genetics, the validation of a clinical chromosomal microarray platform should be performed by testing a large number (200-300) of well-characterized cases, each with unique CNVs located throughout the genome. Because of the Clinical Laboratory Improvement Amendment of 1988 and the lack of an FDA approved whole genome chromosomal microarray platform the ultimate responsibility for validating the performance characteristics of this technology falls to the clinical laboratory performing the testing. To facilitate this task, we have established a computational analytical validation procedure for CGH microarrays that is comprehensive, efficient, and low cost. This validation uses a higher resolution microarray to validate a lower resolution microarray with a receiver operating characteristic (ROC)-based analysis. From the results we are able to estimate an optimal log2 threshold range for determining the presence or absence (calling) of CNVs.

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Relyea, Stephen L. (Stephen Lawrence). "An analytics approach to designing clinical trials for cancer." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82727.

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Thesis (S.M. in Operations Research)--Massachusetts Institute of Technology, Sloan School of Management, Operations Research Center, 2013.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 67-71).
Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer drug research and clinical trials are enormous expenses for pharmaceutical companies and the government. We propose an analytics approach for the analysis and design of clinical trials that can discover drug combinations with significant improvements in survival and toxicity. We first build a comprehensive database of clinical trials. We then use this database to develop statistical models from earlier trials that are capable of predicting the survival and toxicity of new combinations of drugs. Then, using these statistical models, we develop optimization models that select novel treatment regimens that could be tested in clinical trials, based on the totality of data available on existing combinations. We present evidence for advanced gastric and gastroesophageal cancers that the proposed analytics approach a) leads to accurate predictions of survival and toxicity outcomes of clinical trials as long as the drugs used have been seen before in different combinations, b) suggests novel treatment regimens that balance survival and toxicity and take into account the uncertainty in our predictions, and c) outperforms the trials run by the average oncologist to give survival improvements of several months. Ultimately, our analytics approach offers promise for improving life expectancy and quality of life for cancer patients at low cost.
by Stephen L. Relyea.
S.M.in Operations Research

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Wheeler, Zachary. "Treatment of schizoid personality| An analytic psychotherapy handbook." Thesis, Pepperdine University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3604648.

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This volume presents a contemporary psychodynamic treatment for schizoid personality and related non-psychotic schizophrenia-spectrum personality disorders. Recent theoretical advances in psychodynamic nosology and important contributions from a century of psychoanalytic research on schizoid phenomenon are operationalized to provide clinicians with comprehensive suggestions with respect to assessment, technique, format, areas of thematic focus, countertransference, defense, and the process of change with schizoid patients. This handbook was developed as a Stage I treatment manual sufficient for an initial evaluation of feasibility and efficacy in clinical trials. Developing an understanding of the schizoid's personality organization and object relations is the ultimate goal of this handbook and the springboard from which treatment implications are suggested. New research on issues including attachment, neurobiology, etiological factors, relevant adjunct treatments, and medication are included to inform a broad and integrated approach to treatment. Short case vignettes are built in to help the practitioner understand how clinical theory becomes therapeutic process, while navigation tools, including outlines, indexes, summaries, and original flow sheets are included to summarize important concepts and reinforce learning. Self-adherence measures have been developed to aid the therapist in adhering to treatment guidelines.

Keywords: schizoid personality disorder, avoidant personality disorder, schizotypal personality disorder, transference-focused psychotherapy

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Книги з теми "Analytical clinic"

Caroli, Sergio, and Gyula Záray, eds. Analytical Techniques for Clinical Chemistry. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118271858.

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Schenker, Guy R. An analytical system of clinical nutrition. 3rd ed. Mifflintown, Pa: The Author, 1999.

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G, Seiler Hans, Sigel Astrid, and Sigel Helmut, eds. Handbook on metals in clinical and analytical chemistry. New York: M. Dekker, 1994.

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Jungreis, Ervin. Spot test analysis: Clinical, environmental, forensic, and geochemical applications. 2nd ed. New York: Wiley, 1997.

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Spot test analysis: Clinical, environmental, forensic, and geochemical applications. New York: Wiley, 1985.

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Córcoles, Emma P. Biosensors and Invasive Monitoring in Clinical Applications. Heidelberg: Springer International Publishing, 2013.

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W, Walker A., and Great Britain. National Health Service. Supraregional Assay Service. Laboratories., eds. Trace element analyses: [clinical and analytical handbook]. 3rd ed. Guildford: Royal Surrey County Hospital, 1998.

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Rene, Dybkaer, Martin David V, Rowan R. Martin, European Council of Clinical and Laboratory Standardization., International Federation of Clinical Chemistry., and World Health Organisation, eds. Good practice in decentralised analytical clinical measuremenet. Copenhagen: HertzBogtrykkergarden, 1992.

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Caroli, Sergio. Analytical techniques for clinical chemistry: Methods and applications. Hoboken: Wiley, 2012.

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Brandenberger, Hans, and Robert A. A. Maes, eds. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Berlin, New York: DE GRUYTER, 1997. http://dx.doi.org/10.1515/9783110881615.

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Частини книг з теми "Analytical clinic"

Qin, Suideng, and Zhixin Tian. "Analytical Software and Databases in N-Glycoproteomics." In Mass Spectrometry–Based Glycoproteomics and Its Clinic Application, 131–66. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003185833-5.

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Cao, Weiqian, and Pengyuan Yang. "Qualitative and Quantitative Analytical Methods for Intact Glycopeptides." In Mass Spectrometry–Based Glycoproteomics and Its Clinic Application, 91–130. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003185833-4.

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Martin, J. M. Coco, P. Koolwijk, D. E. Martens, J. W. Oberink, C. A. M. van der Velden-de Groot, and E. C. Beuvery. "Development of Analytical Methods for Monitoring the Stability of Antibody Formation by Hybridoma Cells in Continuous Culture Systems." In From Clone to Clinic, 57–65. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3780-5_7.

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Gupta, P. K. "Analytical and Clinical Toxicology." In Problem Solving Questions in Toxicology:, 287–98. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50409-0_23.

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Chute, Christopher G. "Analytics." In Clinical Informatics Study Guide, 163–85. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22753-5_8.

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Kasthurirathne, Suranga N., and Shaun J. Grannis. "Analytics." In Clinical Informatics Study Guide, 227–39. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-93765-2_16.

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Falkmer, Ursula G., and Gerhard W. Hacker. "Standardization and Practical Guidelines of Image DNA Cytometry in Clinical Oncology." In Analytical Morphology, 245–59. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4166-9_12.

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Bansal, Arvind Kumar, Javed Iqbal Khan, and S. Kaisar Alam. "Clinical Data Analytics." In Introduction to Computational Health Informatics, 397–426. Boca Raton : CRC Press, [2020] | Series: Chapman & Hall/CRC data mining and knowledge discovery series: Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9781003003564-8.

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Olsen, Jørn, Kaare Christensen, Jeff Murray, and Anders Ekbom. "Analytical Epidemiology in Clinical Epidemiology." In An Introduction to Epidemiology for Health Professionals, 95–99. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1497-2_15.

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Giavarina, Davide. "The Pre-analytical Phase." In Clinical and Laboratory Medicine Textbook, 47–56. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24958-7_6.

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Тези доповідей конференцій з теми "Analytical clinic"

Yelensky, Roman, Garrett M. Frampton, Alex Fichtenholtz, Sean Downing, Jie He, Frank Juhn, Kristina Brennan, et al. "Abstract 2279: Bringing next generation sequencing (NGS) to the clinic: Analytical validation of a comprehensive NGS-based cancer gene test." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2279.

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Feng, Z. C. "Perturbation Analysis of Global Bifurcations in Parametrically Excited Systems With Zero-to-One Internal Resonance." In ASME 1996 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/imece1996-0432.

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Abstract In this work we study the existence of Silnikov homo-clinic orbits in the averaged equations representing the modal interactions between two modes with zero-to-one internal resonance. The fast mode is parametrically excited near its resonance frequency by a periodic forcing. The slow mode is coupled to the fast mode when the amplitude of the fast mode reaches a critical value so that the equilibrium of the slow mode loses stability. Using the analytical solutions of the unperturbed integrable Hamiltonian system, we evaluate a generalized Melnikov function which measures the separation of the stable and the unstable manifolds of an annulus containing the resonance band of the fast mode. This Melnikov function is used together with the information of the resonances of the fast mode to predict the region of physical parameters for the existence of Silnikov homoclinic orbits.

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Souza, João Victor de Araújo, Monalisa Silva de França, Nayara Karina Ferreira Pereira, Denise Soares de Araújo, Roberta de Oliveira Cacho, Adriano Araújo de Carvalho, and Adna Karolinne Fonseca. "Analysis of physical activity level and sedentary behavior before and after stroke: A cross-sectional study." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.487.

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Introduction: Stroke is a major cause of death and mortality worldwide. The sedentary lifestyle is a modifiable risk factor and the regular practice of physical activity can reduce the recurrence of stroke and its symptoms. Objective: To characterize the level of physical activity of post-stroke patients before and after the event. Methodology: This is a cross-sectional, analytical study. The population of the study consisted of patients diagnosed with stroke, in the chronic phase under treatment or that have already been discharged from the Physiotherapy School Clinic of FACISA in Santa Cruz-RN. The individuals were evaluated by the Modified Baecker Questionnaire for the Elderly (QBMI) that classifies the level of physical activity in: sedentary (-9), active (9 to 16), and athletes (+16). The normality of the variables was verified by the Shapiro-Wilk test. Wilcoxon’s test was used for comparative analysis of QBMI before and after stroke. Results: Nineteen patients participated (8 male and 11 female) with a mean age of 63 years, of these, 11 had systemic hypertension. Before, 3 were classified as sedentary (score mean: 5.34), 5 active (score mean: 12.254) and 1 athlete ( score mean: 27.04). After the stroke, 18 were classified as sedentary (score mean: 1.46) (p=0.001). Conclusion: There was a reduction in the participants’ level of physical activity, showing greater sedentariness after stroke, although physical activity is essential for secondary prevention of stroke.

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Poigai Arunachalam, Shivaram, Mustafa Sir, Gomathi Marisamy, Annie Sadosty, David Nestler, Thomas Hellmich, and Kalyan S. Pasupathy. "Optimizing Emergency Department Workflow Using Radio Frequency Identification Device (RFID) Data Analytics." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3402.

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Emergency Department (ED) is a complex care delivery environment in a hospital that provides time sensitive urgent and lifesaving care [1]. Emergency medicine is an unscheduled practice and therefore providers experience extreme fluctuations in their workload. ED crowding is a major concern that affects the efficacy of the ED workflow, which often is challenged by long wait times, overuse of observation units, patients either leaving without being seen by a provider and non-availability of inpatient beds to accommodate patients after diagnosis [2]. Evaluating ED workflow is a challenging task due to its chaotic nature, with some success using time-motion studies and novel capacity management tools are nowadays becoming common in ED to address workflow related issues [3]. Several studies reveal that Electronic Medical Record (EMR) adoption has not resulted in significant ED workflow improvements nor reduced the cost of ED operations. Since raw EMR data does not offer operational and clinical decision making insights, advanced EMR data analytics are often sought to derive actionable intelligence from EMR data that can provide insights to improve ED workflow. Improving ED workflow has been an important topic of research because of its great potential to optimize the urgent care needed for the patients and at the same time save time and cost. Radio Frequency Identification Device (RFID) is a wireless automatic identification and data capture technology device that has the potential for improving safety, preventing errors, saving costs, and increasing security and therefore improving overall organizational performance. RFID technology use in healthcare has opened a new space in healthcare informatics research that provides novel data to identify workflow process pitfalls and provide new directions [4]. The potential advantages of RFID adoption in healthcare and especially in ED has been well recognized to save costs and improve care delivery [5]. However, the large upfront infrastructure costs, need for an integrated health information technology (HIT), advanced analytical tools for big data analysis emerging from RFID and skilled data scientists to tackle the data to derive actionable intelligence discourage many hospitals from adoption RFID technology despite its potential advantages. Our recent pilot study on the RFID data analytics demonstrated the feasibility of quantifying and analyzing two novel variables such as ‘patient alone’ time defined as the total time a patient spends alone without interaction with a health care staff in the ED and ‘provider time’ defined as the total time a patient spends interacting with any health care staff [6]. The study motivated a more comprehensive big data analytics of RFID data which can provide better insights into optimizing ED workflow which can improve the quality of care in the ED and also reduce cost. In this work, the authors attempt to describe the RFID adoption in the ED at the Saint Mary’s Hospital at Mayo Clinic, in Rochester, MN, a level one trauma center both for children and adults as a step towards optimizing ED workflow.

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Chen, Fuyao, Jianing Wang, Inga Saknite, Melanie D. Patterson, Dan Fabbri, Benoit Dawant, Madan H. Jagasia, and Eric Tkaczyk. "Bringing Biophotonics to Dermatology Patients: Experiences of a New Cutaneous Imaging Clinic." In Microscopy Histopathology and Analytics. Washington, D.C.: OSA, 2018. http://dx.doi.org/10.1364/microscopy.2018.mth4a.2.

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Tolstikov, Vladimir. "Clinical Metabolomics: Analytical Tool for Drug Development." In The 1st International Electronic Conference on Metabolomics. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/iecm-1-a001.

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YANG, Zijun, Shi Zhou, Aoran Xi, Yuting Wang, and Seiichi Serikawa. "Survey: Clinical and analytical techniques of EGG." In The 9th International Conference on Intelligent Systems and Image Processing 2022. The Institute of Industrial Applications Engineers, 2022. http://dx.doi.org/10.12792/icisip2022.018.

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Erkol, Hakan, Farouk Nouizi, alex luk, Mehrnaz Mehrabi, Burcin Unlu, and gultekin gulsen. "A Comprehensive Analytical Based Computational Technique for Laser Induced Heat in a Gold Nano-particle Embedded Turbid Medium." In Clinical and Translational Biophotonics. Washington, D.C.: OSA, 2018. http://dx.doi.org/10.1364/translational.2018.jth3a.16.

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Milovanović, Aleksandar, Velibor Isailović, Igor Saveljić, and Nenad Filipović. "Analytically Computed Fractional Flow Reserve based on Coronary CT Angiography." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.371m.

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Invasively determined Fractional Flow Reserve (FFR) has been recognized as a reliable tool for assessing coronary artery stenosis severity. Since the invasive method is associated with a risk of vessel injury due to pressure wire manipulation several non-invasive techniques have been developed. The objective of this paper is to propose an alternative, much less time-consuming, analytical solution based on Computed Tomography Angiography (CTA) images and the overall pressure drop calculation across the stenosis in the coronary artery. The results obtained using this method are validated by comparing them with the clinical data for patients who underwent invasive coronary angiography as well as with the results obtained by using CFD simulation. FFR determined using the analytical method compared with the clinical and CFD ones differs by 4.5% and 3.9% respectively. This confirms that the analytically determined FFR can be reliable for the physiological assessment of coronary artery stenosis.

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Agnihothri, Saligrama, Anu Banerjee, and Gail Thalacker. "Analytics to Improve Service in a Pre-admission Testing Clinic." In 2015 48th Hawaii International Conference on System Sciences (HICSS). IEEE, 2015. http://dx.doi.org/10.1109/hicss.2015.162.

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Звіти організацій з теми "Analytical clinic"

Burtis, C. (Analytical instrumentation in clinical chemistry). Office of Scientific and Technical Information (OSTI), July 1987. http://dx.doi.org/10.2172/6750988.

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Walker, Alex, Brian MacKenna, Peter Inglesby, Christopher Rentsch, Helen Curtis, Caroline Morton, Jessica Morley, et al. Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY. OpenSAFELY, 2021. http://dx.doi.org/10.53764/rpt.3917ab5ac5.

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This OpenSAFELY report is a routine update of our peer-review paper published in the British Journal of General Practice on the Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY. It is a routine update of the analysis described in the paper. The data requires careful interpretation and there are a number of caveats. Please read the full detail about our methods and discussionis and the full analytical methods on this routine report are available on GitHub. OpenSAFELY is a new secure analytics platform for electronic patient records built on behalf of NHS England to deliver urgent academic and operational research during the pandemic. You can read more about OpenSAFELY on our website.

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Clement, Timothy, and Brett Vaughan. Evaluation of a mobile learning platform for clinical supervision. University of Melbourne, 2021. http://dx.doi.org/10.46580/124369.

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Context: This report details a formative evaluation of the Clinical Supervision Online (CSO) course, a fee-paying, fully online ‘light touch’ program of study for clinical supervisors offered by the Melbourne Medical School, which was developed in conjunction with the University’s Mobile Learning Unit. The course requires between six to ten hours of self-directed study and is designed for any clinicians who teach. Methods: Evaluation of the course was guided by Rossi, Lipsey and Freeman’s (2004) approach to program evaluation, addressing the need for the course, its design, implementation, impact, and return on investment. Data were collected through interviews with key informants, document analysis, an embedded student survey, learning analytics data, financial data, and an audit against ‘best practice’ standards for online course design. Findings: The findings suggest that course development was driven by both a financial imperative and genuine concern to meet training needs of clinical supervisors. Two hundred and four students enrolled on the course in its first 18 months. This has been enough to cover its developmental costs. In relation to 64 quality standards for online course design, the level of performance was rated as ‘meets’ for 44 items; ‘exceeds’ for one item; ‘developing for 13 items’; and, ‘non-existent’ for six items. An additional 33 items were identified as ‘not applicable’ for the ‘light touch’ course design. Significance: From a learning design perspective there is much to like about the CSO course and the outcome of assessing it against the standards for ‘best practice’ online course design suggests that an evolutionary approach - making incremental changes - could improve the course whilst retaining its existing ‘light touch’ format. The CSO course on its own is unlikely to realise the depth of achievement implied in the course aims and learning outcomes. The CSO course may best be seen as an entrée into the art of clinical supervision.

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Zhang, Jack Jiaqi. Theta burst stimulation for hemiplegic upper extremity after stroke: A meta-analytic review of twenty years of clinical and mechanistic evidence. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2024. http://dx.doi.org/10.37766/inplasy2024.1.0069.

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Zhao, Hui Yan, Sungha Kim, ChangSop Yang, and Mi Ju Son. Comparing acupoint catgut embedding and acupuncture therapies in simple obesity: Protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0014.

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Review question / Objective: How effective are acupoint catgut embedding therapy sole or with other treatment? Condition being studied: Simple obesity. Information sources: We will search for trials from the following electronic databases: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Cumulative index to Nursing and Allied Health Literature (CINAHL). Trials will also be searched from three Korean medical databases (Oriental Medicine Advanced Searching Integrated System [OASIS], Science-On and KoreaMed), a Chinese database (Chinese National Knowledge Infrastructure [CNKI]) and a Japanese database (CiNii). Ongoing trials, trials will be searched on the Clinical Trials. gov (http://www.ClinicalTrials.gov), and the WHO International Clinical Trials Registry Platform (ICTRP) (http://apps.who.int/trialsearch/). We will also check the reference lists of reviews and the retrieved articles for additional studies. All bibliographic information and articles will be managed using EndNote (X8.2; Clarivate Analytics, Philadelphia). If the data of study are missing or insufficient, we will contact the corresponding authors by email.

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Parsons, Helen M., Hamdi I. Abdi, Victoria A. Nelson, Amy M. Claussen, Brittin L. Wagner, Karim T. Sadak, Peter B. Scal, Timothy J. Wilt, and Mary Butler. Transitions of Care From Pediatric to Adult Services for Children With Special Healthcare Needs. Agency for Healthcare Research and Quality (AHRQ), May 2022. http://dx.doi.org/10.23970/ahrqepccer255.

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Objective. To understand the evidence base for care interventions, implementation strategies, and between-provider communication tools among children with special healthcare needs (CSHCN) transitioning from pediatric to adult medical care services. Data sources. We searched Ovid MEDLINE, Ovid Embase, the Cochrane Central trials (CENTRAL) registry, and CINAHL to identify studies through September 10, 2021. We conducted grey literature searches to identify additional resources relevant to contextual questions. Review methods. Using a mixed-studies review approach, we searched for interventions or implementation strategies for transitioning CSHCN from pediatric to adult services. Two investigators screened abstracts and full-text articles of identified references for eligibility. Eligible studies included randomized controlled trials, quasi-experimental observational studies, and mixed-method studies of CSHCN, their families, caregivers, or healthcare providers. We extracted basic study information from all eligible studies and grouped interventions into categories based on disease conditions. We summarized basic study characteristics for included studies and outcomes for studies assessed as low to medium risk of bias using RoB-2. Results. We identified 9,549 unique references, 440 of which represented empirical research; of these, 154 (16 major disease categories) described or examined a care transition intervention with enough detail to potentially be eligible for inclusion in any of the Key Questions. Of these, 96 studies met comparator criteria to undergo risk of bias assessment; however only 9 studies were assessed as low or medium risk of bias and included in our analytic set. Low-strength evidence shows transition clinics may not improve hemoglobin A1C levels either at 12 or 24 months in youth with type 1 diabetes mellitus compared with youth who received usual care. For all other interventions and outcomes, the evidence was insufficient to draw meaningful conclusions because the uncertainty of evidence was too high. Some approaches to addressing barriers include dedicating time and resources to support transition planning, developing a workforce trained to care for the needs of this population, and creating structured processes and tools to facilitate the transition process. No globally accepted definition for effective transition of care from pediatric to adult services for CSHCN exists; definitions are often drawn from principles for transitions, encompassing a broad set of clinical aspects and other factors that influence care outcomes or promote continuity of care. There is also no single measure or set of measures consistently used to evaluate effectiveness of transitions of care. The literature identifies a limited number of available training and other implementation strategies focused on specific clinical specialties in targeted settings. No eligible studies measured the effectiveness of providing linguistically and culturally competent healthcare for CSHCN. Identified transition care training, and care interventions to

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Svynarenko, Radion, Theresa L. Profant, and Lisa C. Lindley. Effectiveness of concurrent care to improve pediatric and family outcomes at the end of life: An analytic codebook. Pediatric End-of-Life (PedEOL) Care Research Group, College of Nursing, University of Tennessee, Knoxville, 2022. http://dx.doi.org/10.7290/m5fbbq.

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Implementation of the section 2302 of the 2010 Patient Protection and Affordable Care Act (ACA) enabled children enrolled in Medicaid/Children's Health Insurance Program with a prognosis of 6 months to live to use hospice care while continuing treatment for their terminal illness. Although concurrent hospice care became available more than a decade ago, little is known about the socio-demographic and health characteristics of children who received concurrent care; health care services they received while enrolled in concurrent care, their continuity, management, intensity, fragmentation; and the costs of care. The purpose of this study was to answer these questions using national data from the Centers of Medicare and Medicaid Services (CMS), which covered the first three years of ACA – from January 1, 2011, to December 31, 2013.The database included records of 18,152 children younger than the age of 20, who were enrolled in Medicaid hospice care in the sampling time frame. Children in the database also had a total number of 42,764 hospice episodes. Observations were excluded if the date of birth or death was missing or participants were older than 21 years. To create this database CMS data were merged with three other complementary databases: the National Death Index (NDI) that provided information on death certificates of children; the U.S. Census Bureau American Community Survey that provided information on characteristics of communities where children resided; CMS Hospice Provider of Services files and CMS Hospice Utilization and Payment files were used for data on hospice providers, and with a database of rural areas created by the Health Resources and Services Administration (HRSA). In total, 130 variables were created, measuring demographics and health characteristics of children, characteristics of health providers, community characteristics, clinical characteristics, costs of care, and other variables.

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FEDOTKINA, S. A., O. V. MUZALEVA, and E. V. KHUGAEVA. RETROSPECTIVE ANALYSIS OF THE USE OF TELEMEDICINE TECHNOLOGIES FOR THE PREVENTION, DIAGNOSIS AND TREATMENT OF HYPERTENSION. Science and Innovation Center Publishing House, 2021. http://dx.doi.org/10.12731/978-0-615-67320-2-4-22.

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Introduction. The economic losses associated with disability due to diseases of the circulatory system, as well as the costs of providing medical care to patients suffering from heart and vascular diseases, are increasing annually. The state preventive measures currently being carried out are of a delayed nature. The results of the medical examination of the population of the Russian Federation in recent years (2015-2019) indicate that the incidence of cardiovascular diseases, including hypertension, is at a fairly high level. In the middle of the last century, the Concept of risk factors for the development of chronic non-communicable diseases were formulated, in the structure of which cardiovascular diseases, including arterial hypertension, occupies one of the primary positions. The concept is based on the results of promising epidemiological studies, and, at present, is a methodological basis for planning and organizing primary prevention of cardiovascular diseases. The purpose of the study. Based on the analysis of literary sources (including foreign ones) containing experience in the use of telemedicine technologies, to assess their significance for the prevention, diagnosis and treatment of hypertension, as well as forecasting improvements in the quality of medical care when adapting to the use of clinical recommendations. Materials and methods. The article provides an analytical review of the use of modern telemedicine technologies in the prevention of hypertension. The results of the study and their discussion. The analysis of literary sources has shown that in the context of the progress of information and telecommunication technologies in the healthcare system, a fundamentally new direction has appeared in the organization and provision of medical care to the population - telemedicine, which will ensure the modern level of prevention, detection and treatment of chronic non-communicable diseases, and also determines positive medical, social and economic performance indicators. To date, updates in the legislative framework of the Russian Federation are aimed at ensuring that medical care with the use of telemedicine technologies is more widespread, taking into account the standards of medical care and clinical recommendations. Conclusion. Based on a review of literature sources, it has been established that the modern solution to the problem of improving the quality of medical care for patients, including those with hypertension, diseases is medical care using telemedicine technologies that prove their medical, social and economic effectiveness.

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Walker, Michael, Gill Holcombe, Clare Mills, Chiara Nitride, and Adrian Rogers. Development of Reference Materials for food allergen analysis. Food Standards Agency, June 2023. http://dx.doi.org/10.46756/sci.fsa.hwt621.

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Food hypersensitivity is an increasing problem for many stakeholders with much effort focused on assessment and management of the risks including risk assessment toolkits (for example, the Allergen Bureau (Opens in a new window) Voluntary Incidental Trace Allergen Labelling VITAL®, the iFAAM consortium (Opens in a new window) and the ILSI-Europe Allergen Quantitative Risk Assessment guidance (Opens in a new window)). These toolkits describe the use of action levels and reference doses to assess the risks. A combination of the estimated eliciting dose of allergenic food, (in milligrams as protein) and the amount of food consumed in a single eating occasion can give a threshold or action level as milligrams (as protein) per kilogram (kg) of food) (mg kg-1 as protein) that would provoke an reaction in a given proportion of the allergic population. The eliciting dose is extrapolated from oral food clinical dose-distribution relationships. The results of analysis can be compared to the thresholds or action levels in risk assessment and risk management. Precautionary allergen labelling, well recognized as sub-optimal, could also be improved via an action level approach. Implementation and regulation depend on the ability to measure allergens properly; yet all current analytical approaches exhibit deficiencies, many of which can be addressed by the proper use of appropriate allergen reference materials (RMs). This report describes a pilot project to: 1) Systematically review allergen analytical targets used in ELISA, PCR and MS to allow the creation of a repository of reliable markers and open access verified allergen sequence sets for the studied allergens; 2) Facilitate a guided stakeholder workshop to achieve consensus on priority allergens, physical format of RMs, incurred concentrations and impact of processing; 3) Prepare a RM kit containing (a) a food matrix shown to be devoid of the target allergens, (b) the food matrix incurred with 5 allergens and (c) the raw materials (the allergenic foods); 4) Disseminate to encourage RM use to achieve tangible improvements in allergen analysis, establish a template of best practice for the future and make recommendations for follow up work to complete a set of RMs for the legislated and priority allergens. The RM matrix is based on that used for clinical dose-distribution studies and the raw allergen materials have been characterised by proteomics. The matrix and incurred allergens are industrially relevant to processed foods and the allergen concentrations are clinically relevant in the light of eliciting dose studies. The RM kit has been prepared following a well-established process that includes prescribed homogeneity and stability studies and a formal sign-off procedure of the statements of measurement, in accordance with ISO 17034:2016 ‘General requirements for the competence of reference material producers’ (an updated standard originally ISO GUIDE 34:2009). In October 2020 following detailed external assessment the RM kit was confirmed within the NML scope of ISO 17034 accreditation. ISO 17034:2016 covers the production of all reference materials, including certified reference materials. It is intended as part of the general quality assurance procedures of the reference material producer. LGC formed a consortium which was awarded this project by the FSA following an open competitive tender. The consortium consisted of LGC, the University of Manchester and Romer Laboratories Ltd. The consortium is world leading in (a) the preparation, curation and distribution of RMs in an accredited environment and (b) the characterisation of allergen proteins. Synergy with other concurrent work (for example, by iFAAM, EFSA, ILSI, MoniQA, JRC, and AOAC) has ensured value for money. This report has been compiled from a review of a broad range of data sources including: the scientific literature the tender documents progress reports and minutes of project meetings LGC internal documents and in particular the Material Report[1] UoM reports Romer Lab reports.

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