Готові списки джерел за темами / Aggressiveness

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Добірка наукової літератури з теми "Aggressiveness"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 31 липня 2024

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Статті в журналах з теми "Aggressiveness"

1

Ramdhania, Diasya Zulfa, and Hayu Wikan Kinasih. "PENGARUH LIKUIDITAS, LEVERAGE, DAN INTENSITAS MODAL TERHADAP AGRESIVITAS PAJAK DENGAN UKURAN PERUSAHAAN SEBAGAI VARIABEL MODERASI." Dinamika Akuntansi Keuangan dan Perbankan 10, no. 2 (November 15, 2021): 93–106. http://dx.doi.org/10.35315/dakp.v10i2.8876.

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Анотація:
This study aims to examine the effect of liquidity, leverage, capital intensity on tax aggressiveness, and moderated by company size. This study conducted in manufacturing entities listed on the IDX (Indonesia Stock Exchange) over the period of 2017-2019. This study used 63 manufacturing companies and 181 samples. The method of analysis used in this research is multiple linear regression and moderated regression analysis(MRA) to prove the role of moderating variabel. The results show that Leverage had an effect on tax aggressivenes, whereas liquidity,capital intensity and firm size had no effect on tax aggressivenes. This study also prove that firm size weakens the relationship between leverageand tax aggressiveness, while firm size not proven as a moderating variable on the relationship between liquidity, capital intensity on tax aggressiveness. Keywords: liquidity, leverage, capital intensity, company size and tax aggressiveness
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2

Dinic, Bojana, and Snezana Smederevac. "Position of aggressiveness in common latent space of PEN model and model Big Five Plus Two." Psihologija 45, no. 3 (2012): 295–310. http://dx.doi.org/10.2298/psi1203295d.

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The purpose of this research was to examine the relations between different aspects of aggressiveness and personality traits. Buss-Perry Aggression Questionnaire (AQ), Eysenck Personality Questionnaire (EPQ), which represent psychobiological model, and inventory Big Five Plus Two Inventory (BF+2), which represent psycholexical model of personality in Serbian language, were administered to 478 participants. The results revealed that affective impulsive aggressiveness and predatory or instrumental aggressiveness could be identified in the aggressiveness - personality traits relationships. Those aspects of aggressiveness could take manifest or latent character. As expected, Psychoticism from EPQ, Aggressiveness, and Negative Valence from BF+2 showed a significant contribution to all identified forms, except for Aggressiveness in relations with ?acting out? physical aggression. Although these personality traits carry out significant loadings, these loadings were not always the highest. Affective-impulsive aggressiveness, which was mainly determined by the components of latent domain AQ, was related to Neuroticism from both models. The remaining forms of manifest aggressiveness were related to low Consciousness, whereas Physical aggression is connected to Extraversion and Oppennes. This connection represents possible ?acting out? reaction or more frequent tendency of impulsive physical aggression. The results showed that aggressiveness represents a multidimensional construct which could be explained by specific constellation of personality traits, depending which aspects of aggressivenes are of interest.
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3

Hurrohma, Nurizah, and Meta Ardiana. "Pengaruh Likuiditas dan Leverage Terhadap Agresivitas Pajak (Study kasus Perusahaan Manufaktur pada Sub Sektor Food and Beverage yang Terdaftar di BEI Tahun 2016-2019)." JFAS : Journal of Finance and Accounting Studies 3, no. 2 (June 8, 2021): 110–19. http://dx.doi.org/10.33752/jfas.v3i2.288.

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Анотація:
Tax aggressivenes is a action taken by a company to reduce taxable income by avoiding tax. The pupose of this study was to examne and analyze the effect of liquidity and leverage on tax aggressiviness. This research was conducted on the Indinesia Stok Exchange by selecting the population in the foood and beverage sub-sector for the 2016-20019 period and using a purposive sampling method. The type oof research used is quantitative research. The results of this study indicate thaat the result of the first test show that the liquidity variable does not have a significant effect on tax aggressiveness. The results of testing the secound hypothesis show that the leverage variable is not proven to have a significant effect on corporate tax aggressiveness. Keywords: Liquidity, Leverage, Tax Aggressivenes.
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4

Luke, Luke, and Zulaikha Zulaikha. "ANALISIS FAKTOR YANG MEMPENGARUHI AGRESIVITAS PAJAK (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar di Bursa Efek Indonesia Pada Tahun 2012-2014)." JURNAL AKUNTANSI DAN AUDITING 13, no. 1 (May 31, 2016): 80–96. http://dx.doi.org/10.14710/jaa.13.1.80-96.

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This study aims to examine empirically the effect of corporate social responsibility (CSR), return on asset (ROA), inventory intensity, and size of firm to tax aggressiveness. The population of this research was all manufacturing companies listed on the Indonesia Stock Exchange in the period 2012-2014. Sampling technique used was purposive sampling method. There were 190 companies that fulfilled the criteria of sampling. The result of this study showed that corporate social responsibility (CSR) and inventory intensity have negative significant influence to tax aggressivensess. Meanwhile, return on asset (ROA) and size of firm have positive significant relationship to tax aggressiveness.
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Hidayat, Kholid, Arles P. Ompusunggu, and H. Suratno H. Suratno. "PENGARUH CORPORATE SOCIAL RESPONSIBILITY TERHADAP AGRESIVITAS PAJAK DENGAN INSENTIF PAJAK SEBAGAI PEMODERASI (STUDI PADA PERUSAHAAN PERTAMBANGAN YANG TERDAFTAR DI BEI)." JIAFE (Jurnal Ilmiah Akuntansi Fakultas Ekonomi) 2, no. 2 (March 12, 2018): 39–58. http://dx.doi.org/10.34204/jiafe.v2i2.543.

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Анотація:
This study is aimed to examine the effect of Corporate Social Responsibility (CSR) to tax aggresiveness with tax incentive as a moderator. The study population used was the mining companies listed in Indonesia Stock Exchange with sample consisted of 34 companies which were obtained by purposive sampling method between 2011 and 2015. This study used CSR (as independent variable), tax aggressiveness (as dependent variable) and tax incentive (as moderating variable). To control the effect of CSR to tax aggressiveness, this study used variable controls namely leverage, size, Return On Assets (ROA), capital intensity and inventory intensity. While dependent variable, tax aggressiveness, was measured by using a proxy: Effective Tax Rate (ETR). CSR has been carried out by using Corporate Social Responsibility Index (CSRI) and data analysis technique has been done by using Moderated Regression Analysis (MRA). In addition the data was processed by using SPSS 22. The result showed that CSR has negative influence to tax agressiveness. The higher the level of corporations CSR disclosure, the lower is the level of tax aggressiveness.Tax incentives was proven and capable to strenghthen the relation between CSR and tax aggressivenes. CSR simultantly tested with the control variables showed similar result. It has negative influence.The higher the level of corporations CSR disclosure, the lower is the level of tax aggressiveness.Keywords: CSR, Tax Aggressivenes, Tax Incentives
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6

Knudsen, Russell. "Balding Aggressiveness and the Balding Aggressiveness Index (BAI)." International Society of Hair Restoration Surgery 29, no. 1 (January 2019): 16–17. http://dx.doi.org/10.33589/29.1.0016.

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7

Warsono, Warsono, and Yuli Ardianto. "Pengaruh Corporate Social Responsibility Terhadap Agresivitas Pajak dengan Insentif Pajak Sebagai Pemoderasi. (Studi pada perusahaan pertambangan di Indonesia)." Jurnal Manajemen dan Bisnis Indonesia 2, no. 2 (February 1, 2015): 236–49. http://dx.doi.org/10.31843/jmbi.v2i2.52.

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Анотація:
This study aims toexamine the effectofcorporatesocialresponsibility(CSR) to taxaggresiveness with the tax incentive as a moderator. The study population used is the mining companies listed in Indonesia Stock Exchange. Sampling method using purposive samplingobtained by 34 companies of reach with 2011-2015. This study used Corporate Social Responsibility (as independend variable) and Tax Aggressiveness(as dependend variable) and Tax Incentive (as moderating vatriable). Tocontrol the effect of CSR to tax aggresiveness,primarily as a result of the use of moderating variable,this study used variable controls :Leverage, Size, Return on Assets (ROA), Capital Intensity and Inventory Intensity. The dependent variable in this study is tax aggressiveness. It was measured by usingproxy :effective tax rate(ETR).CSR has been carried out by using Corporate Social Responsibility Index (CSRI).Data analysis technique has been done by using Moderated Regression Analysis (MRA). The data was processed using SPSS 22. The result shows that CSR has negative influence to tax agressiveness. The higherthelevelof CSR disclosure of acorporation, thelower isthelevelof tax aggressiveness.Tax incentives is proven and capable to strenghthen the relations between CSR and Tax Aggressivenes. CSR stimultantly tested with the control variables showed similar result that it has negative influence the higherthe levelof CSR disclosure of acorporation, thelower isthelevelof tax aggressiveness. Keywords: Corporate Social Responsibility, Tax Aggressiveness, Efective Tax Rate
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8

Apriyanti, Hani Werdi, and Muhamad Arifin. "Tax aggressiveness determinants." Journal of Islamic Accounting and Finance Research 3, no. 1 (April 30, 2021): 27–52. http://dx.doi.org/10.21580/jiafr.2021.3.1.7412.

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Анотація:
Purpose - This study aims to examine the effect of capital intensity, inventory intensity, corporate social responsibility and good corporate governance on tax aggressiveness. Good corporate governance variables used in this study were proxied with independent commissioners and audit commitments.Method - This research focused on manufacturing companies listed on the Indonesia Stock Exchange in the period of 2016-2018. 177 samples were collected using a purposive sampling technique from 59 companies over an observation period of 3 consecutive years. The samples were then analyzed using a multiple linear regression.Result - The results of this study show that capital intensity has a positive and significant effect on tax aggressiveness, inventory intensity has a positive but not significant effect on tax aggressiveness, corporate social responsibility has no positive and significant effect on tax aggressiveness, Independent commissioner has a positive and significant effect on tax aggressiveness, and audit committee has a negative but significant effect on tax aggressiveness.Implication - The results show that the company with high capital intensity tends to be more aggressive on tax. Therefore, the tax authorities must be aware to companies with these characteristics.Originality - The addition of corporate social responsibility and good corporate governance as independent variables are thought to be related to the company’s tax aggressiveness.
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9

Hamrin, Tina. "Dance as Aggressiveness." Scripta Instituti Donneriani Aboensis 16 (January 1, 1996): 175–92. http://dx.doi.org/10.30674/scripta.67228.

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The woman who founded Tenho-kötai-jingii-kyö, Kitamura Sayo (1900-1967), publicly announced in July 1945 that the world was coming to an end and that she had been chosen by the absolute deity Tensho Kotai Jingu to be the savior of the world. People began to gather to her banner, a religious organization was formed, and legal incorporation of the group as a religious juridical person took place in January 1947. Teaching that regret, desire, hatred, love and other emotional antipathies were the cause of all misfortune, the founder urged people to free themselves of such restraints by praying earnestly until they attained a state in which the self was completely forgotten. Since the members of the group perform a ritual dance and fall into an ecstatic condition at the group meetings, the movement is called the Dancing Religion.
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10

DeWine, Sue, Anne Maydan Nicotera, and Doug Parry. "Argumentativeness and Aggressiveness." Management Communication Quarterly 4, no. 3 (February 1991): 386–411. http://dx.doi.org/10.1177/0893318991004003008.

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Дисертації з теми "Aggressiveness"

1

Chamberlain, Jude Martin. "Disentangling Aggressiveness and Assertiveness Within the MMPI-2 PSY-5 Aggressiveness Scale." Kent State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=kent1257555806.

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2

Clark, Corinna C. A. "Understanding the phenotype of aggressiveness." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/27801.

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Анотація:
Consistency of aggressiveness within and between situations was examined using a repeated social challenge test (Resident Intruder Test) at various key stages during the lifetime of male and female growing (meat) pigs and a subset of female breeding pigs. Behaviour during mixing at weaning and as gilts was examined and information was collected about the way in which these animals behaved in a social context, including measures related to, but not directly correlated with aggression, such as social status. The effects of age/maturity and experience were also considered. To understand how aggression might integrate within personality the various social measures were compared with cortisol (as a physiological indicator of stress) an a challenging situation unrelated to social confrontation; maternal behaviour was chosen as it is commercially relevant and has important implications for the welfare of gilts and piglets. Pigs were consistent in their responses to the RIT, but there were differences between sexes. Aggressiveness was consistent over a long period of time in female pigs, even with a gap of 90 days between tests and the onset of puberty. Male pigs showed an unexpectedly high level of mounting behaviour from a young age, which increased with maturity. Experience of the RIT improved consistency of responses and age at first testing affected both the speed of attacking and occurrence of attacks; those pigs experiencing the test when younger were more likely to and quicker to attach. RIT aggressiveness was however, not predictive of subsequent aggressiveness at mixing. As with the RIT, there were clear sex-differences observed during mixing at weaning with males being more aggressive, more successful in fights, more likely to mount and less likely to play than females. Pigs employed different strategies during mixing, the extremes of which were categorised by high-play-low-aggressiveness and vice versa. As expected, aggressive individuals were involved in more fights and won more fights, but suffered more skin lesions than non-aggressive individuals. Pigs that engaged in high-playing were generally the least successful in fights, but suffered fewer lesions and had equal ultimate dominance rank to aggressive pigs. The structure of the mixes changes between weaning and puberty. Fighting ceased sooner during the gilt mix, but aggression was more frequent and more severe. Gilts that reacted aggressively to their piglets were more aggressive and successful in the mix and more ‘reactive’ during farrowing. There were other links between farrowing and mixing behaviour, such as more frequent posture changes but less frequent nesting with greater mix-aggressiveness; indicating that aggressiveness and maternal behaviour are linked through personality.
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3

Kairis, Victoria. "Fathers' contribution towards toddlers' aggressiveness." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/60771/.

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In this thesis I investigated the relationship between fathers’ antisocial and physically aggressive behaviour and toddlers’ behaviour. Previous work has largely ignored fathers or seen fathers only as an influence on mothers and little is known about fathers’ aggressiveness. Families were recruited for the Cardiff Child Development Study (CCDS), which is a prospective longitudinal study of parents and their children. Parents were interviewed about their own behaviours during pregnancy and the children were assessed at intervals until 33 months of age (Chapter 2 describes the study design). Chapter 3 examined associations between the antisocial behaviour of the couple. Although men committed more antisocial behaviours than women, there were associations between partners’ rates of both violent and non-violent antisocial behaviours. The relationship between fathers’ antisocial behaviours and young children’s behaviour was explored in Chapter 4. Fathers’ non-violnt antisocial symptoms were associated with mothers’ reports of toddlers’ aggressiveness. Fathers’ physical aggressiveness was associated with infants’ contentious behaviours, toddlers’ aggressiveness and observations of toddlers’ use of force against a peer. When physical aggressiveness was considered more closely a component relating specifically to toddlers’ physical aggressiveness was identified. Fathers’ physical aggressiveness was associated with toddlers’ physical aggressiveness, which suggests a homotypic continuity in physical aggressiveness between fathers and toddlers. All of the associations between fathers’ and toddlers’ behaviours remained significant after controlling for the mothers’ behaviours. Thus, fathers’ behaviours provide unique contributions towards toddlers’ behaviours independently of the mothers’ behaviours. Since antisocial fathers are more likely to be absent fathers Chapter 5 examined the relationship between fathers’ physical aggressiveness and father absence. Although father absence was associated with fathers’ physical aggressiveness, it did not explain the association between fathers’ and toddlers’ physical aggressiveness. Together these findings show that fathers are important to study in their own right, rather than as an influence on mothers.
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4

Buslig, Aileen Laura Suzanne 1966. "Aggressiveness in privacy-seeking behavior." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290660.

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Анотація:
Almost everyone experiences the desire for privacy occasionally. Achieving privacy, on the other hand, can be more difficult, especially when relational concerns are present. While the topic of privacy has received a good deal of attention in a variety of fields (e.g., communication, law, psychology, architecture, sociology), the impact of the act of seeking privacy has received little study. Privacy-seeking is often considered a selfish act, one that is likely to make the seeker feel guilty and the other affected parties rejected. The purpose of the present study is to examine the aggressiveness of various strategies that people use to gain privacy. In the present study, privacy-seekers described how they tried to achieve privacy in a particular situation, the reasons and motivations behind their actions, their perceptions of the situation and their own behavior, and the consequences of their actions. Results indicated that the use of moderate aggressiveness may be a superior strategy for achieving privacy with relational sensitivity, in comparison to aggressive or nonaggressive strategies. Aggressive strategies were seen as more dominant, less pleasant and less composed, and resulted in more negative relational consequences, than moderately aggressive strategies, while nonaggressive strategies were seen as less dominant, equally pleasant and composed, but less satisfying to use than moderately aggressive strategies. The relationship of the intruder (friend or stranger) also played a role in how participants sought privacy. However, no setting effects were found for perceptions of the environment or type of territory and use of aggressiveness.
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5

McInerney, Megan Michelle. "Analyst Coverage and Tax Reporting Aggressiveness." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/37634.

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Анотація:
The role of analysts in corporate governance has been examined extensively in the accounting literature. Two conflicting representations of the influence of analysts have emerged. Analysts are either viewed as external monitors of corporate behavior, thereby reducing agency costs; or they are viewed as exerting additional pressure on management to meet earnings forecasts, which may contribute to aggressive corporate behavior. Studies exist that examine the impact of analyst coverage in a financial reporting context. The purpose of this study is to examine the role of analysts in the corporate tax reporting context. This dissertation examines the impact of analyst coverage on corporate tax aggressiveness using a cross-section of publicly traded firms between 1992 and 2006. Permanent discretionary book-tax differences are used to proxy for tax aggressiveness. The relation is examined using ordinary least squares regression as well as two-stage least squares regression using expected coverage and inclusion in the S&P 500 index as instrumented variables to account for the endogeneity of analyst coverage selections. Additional analyses investigate the impact of analyst characteristics: experience as an analyst, experience covering a specific firm and identification as a top analyst. Results indicate that analyst coverage is associated with lower levels of tax aggressiveness. This finding suggests that analysts serve as external monitors of corporate tax behavior. In addition, more experienced analysts are associated with lower levels of tax aggressiveness indicating an improvement in monitoring ability with experience. Analysts identified as All-American analysts by Institutional Investor magazine are associated with higher levels of tax aggressiveness. This result suggests that top analysts may view aggressive tax behavior as a wealth creation tool for firms.
Ph. D.
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6

ZHOU, Ying. "Ownership structure, board characteristics, and tax aggressiveness." Digital Commons @ Lingnan University, 2011. https://commons.ln.edu.hk/acct_etd/3.

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Анотація:
Tax aggressiveness, as commonly proxied by the effective tax rate (ETR), measures a firm’s effort spent on minimizing its tax payments. It is suggested that more tax aggressive firms have greater incentives to allocate resources to minimize taxes and thus have lower ETRs. Corporate governance has been continuously receiving attention in literature across different fields and can affect a firm’s tax strategy through its control mechanism. This thesis investigates how corporate governance influences a firm’s tax aggressiveness. The main hypothesis of this thesis is whether firms with good corporate governance will have less incentives and opportunities to manage tax aggressively. Specifically, I take advantages of the distinct institutional settings in China to study whether the Chinese firm’s tax aggressiveness is affected by ownership structure and the characteristics of board of directors. Using all non-financial listed companies in the Chinese A-share market during 2003 and 2009 period, I find that firms with state-controlled nature and lower proportion of controlling shares pursue less aggressive tax strategies and maintain higher ETRs. In addition, my finding is consistent with prior literature that a higher percentage of the boards’ shareholdings and dual service duties performed by the board chairman result in lower ETRs. However, I do not find a significant relationship between the percentage of independent directors and tax aggressiveness which may suggest the ineffective role of independent directors in China.
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7

ROS, GLORIA. "ROLE OF HMGA1 IN BREAST CANCER AGGRESSIVENESS." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908068.

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Breast cancer is the most common cancer in women and a leading cause of cancer mortality worldwide, mainly due to metastatic progression. Although in the last years cancer has become more curable, the path to eradicate it, is still long and convolute. Understanding molecular mechanisms that induce and support cancer progression and aggressiveness is crucial to find new targets and drugs to treat it. High Mobility Group A1 (HMGA1) protein is an oncofetal architectural chromatin factor that promotes neoplastic transformation and progression but its role in breast cancer aggressiveness is still unclear. The aim of this thesis was to unravel the involvement of HMGA1 in this disease highlighting which pathways are intersected. Thus, working on basal-like breast cancer subtype, we demonstrated that HMGA1 plays a crucial role in conferring metastatic traits. Indeed, HMGA1 silencing reduces migration and invasion properties in vitro and metastasis formation in vivo with a concomitant mesenchymal to epithelial transition and decreases stem cell properties and self-renewal activity. We performed microarray analysis in cells expressing or depleted for HMGA1 and we identified a specific 130-HMGA1 gene signature associated with poor prognosis. This analysis allowed us to identify pathways, controlled by HMGA1 and known to be involved in aggressiveness traits, such as Wnt/beta-catenin and Notch. Moreover, among the genes present in the 130-HMGA1 gene signature we deepen the relationship between HMGA1 and CCNE2, one of the gene most correlated with clinical outcome. We showed that CCNE2 acts downstream HMGA1 to regulate the migration and invasion proprieties of basal-like breast cancer cells. Moreover, we demonstrated that CCNE2 action is mediated by the oncogene YAP, the downstream effector of the Hippo pathway. Indeed, knock down of both HMGA1 and CCNE2 impaired nuclear localization and activity of YAP, acting upstream of the Hippo pathway core kinases MST1/2 and LATS1/2. Moreover, in breast cancer patients, HMGA1 and CCNE2 expression was associated with YAP/TAZ signature further supporting this connection. Because CDKs are the main partners of CCNE2, we blocked their activity using CDK inhibitors in order to impair HMGA1-CCNE2-YAP axis and we demonstrated a decrease in cell migration and an induction of translocation of YAP from nucleus to cytoplasm. Therefore, this thesis highlights the involvement of HMGA1 in breast cancer metastasis through the interplay with different pathways. In particular, we identified for the first time a role of HMGA1 in regulating YAP through the modulation of the Hippo pathway.
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Enfield, Catherine S. "A multidimensional approach to understanding lung tumour aggressiveness." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62058.

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9

Goldman, Nathan Chad, and Nathan Chad Goldman. "The Effect of Tax Aggressiveness on Investment Efficiency." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/612100.

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Анотація:
Tax aggressiveness generates significant cash savings and information asymmetry. Combining these two consequences of tax aggressiveness, I suggest that tax aggressiveness is associated with higher agency costs of free cash flows that affect investment decisions. Using the conditional investment efficiency model, I find evidence that tax aggressiveness is associated with more investments in firms with high access to investable funds, thus suggesting tax aggressiveness is associated with overinvestment. I also provide evidence that stronger tax monitoring and a change in tax disclosures mitigate the relation between tax aggressiveness and overinvestment. Lastly, I find that the overinvestment is associated with lower future abnormal returns. Thus, my results suggest that poor managerial investment decision making is an unintended consequence to tax aggressiveness. Additionally, I further the need for shareholders and board of directors to exert influence to avoid compensating managers for aggressive tax strategies.
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10

Montuori, Giulia. "The m6A RNA modification sustains neuroblastoma tumour aggressiveness." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276989.

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Анотація:
The N6-methyladenosine, also known as m6A, is the most common post-transcriptional modification in mRNAs and long non-coding RNAs and that profoundly influences mRNA biology, from early processing in the nucleus to final steps of translation and decay in the cytoplasm. Taking into consideration the importance of RNA in shaping cell fate, m6A is widely recognized as an additional layer in the regulation of gene expression, also thanks to its dynamic and reversible nature. Therefore, it is not surprising that any misregulation in m6A content might lead to the loss of cellular homeostasis. This effect is particularly evident when it comes to stem cells differentiation, embryo development and cancer. In a tumorigenic context, the m6A could affect the development, progression, cancer stem cells (CSCs) renewal and drug resistance of solid and liquid tumours. So, the m6A is consistently becoming a new attractive pharmacological target. Neuroblastoma (NB) is a neuroendocrine tumour of early childhood that derives from undifferentiated cells of the sympathoadrenal lineage of the neural crest. About 50% of patients have a very aggressive form of NB, with an overall survival rate of less than 30% despite heavy treatments. Moreover, NB is a challenging druggable tumour due to a low rate of somatic mutations. Somatic mutations at significant frequency have been identified in only five genes that also show detectable expression. Among these, only one is currently a directly validated druggable target. Two m6A regulators (METTL14 and ALKBH5) are aberrantly expressed in high-risk NB patients, and their alteration in NB cell lines affects tumour aggressiveness. Specifically, the overexpression of the methyltransferase METTL14 increases cell proliferation and invasion in vitro and tumour growth in mice acting as an oncogene, while ALKBH5 restoration affects cell proliferation, apoptosis and invasion in an opposite fashion. Importantly, the demethylase ALKBH5 impaired tumour formation in vivo when costitutively expressed and dramatically slows down tumor progression in mice when is induced by causing massive apoptosis. These data suggest that ALKBH5 acts as a potent tumour suppressor in NB. We discovered that METTL14 and ALKBH5 exert their effect on different levels by affecting mRNA stability or translation, respectively. Although the contribution to NB of the altered stability of transcripts related to mRNA processing in METTL14-overexpressing cells is less understand, the increase translation of pro-apoptotic genes in the ALKBH5-overexpression condition leaves little doubts. Our results unveil the m6A and its regulators as potential therapeutic targets for treating NB. Indeed, in collaboration with the Laboratory of Genomic Screening of Professor Alessandro Provenzani, we presented an encouraging proof-of-concept of the reader YTHDF1 as a possible pharmacological target.
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Книги з теми "Aggressiveness"

1

Beck, Paul J. Uncertainty and taxpayer aggressiveness: Experimental evidence. [Urbana, Ill.]: College of Commerce and Business Administration, University of Illinois at Urbana-Champaign, 1989.

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2

MacLaughlin, T. F. Crashworthiness, aggressiveness and crash test procedures. Washington, D.C: National Highway Traffic Safety Administration, 1985.

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3

Kennedy, Leslie W. Violent outcomes: Self-control and aggressiveness in violent offenders. Edmonton, Alta: Centre for Criminological Research, University of Alberta, 1995.

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4

Terelak, Jan F. Psychology of aggression: Selected issues. Warszawa: Wydawn. Uniwersytetu Kardynała Stefana Wyszyńskiego, 2011.

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5

Näsirova, Nailä. Insan aqressiv väziyyätdä: Konsepsiyalar mänbälär problemlär. Bakı: Info, 2004.

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6

Selg, Herbert. Psychologie der Aggressivität. 2nd ed. Göttingen: Hogrefe, 1997.

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7

Drozdov, O. I͡U. Problemy ahresyvnoï povedinky osobystosti: Navchalʹnyĭ posibnyk. Chernihiv: Chernihivsʹkyĭ derz͡h. pedahoh. universytet im. T.H. Shevchenka, 2000.

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8

1932-, Geen Russell G., and Donnerstein Edward I, eds. Human aggression: Theories, research, and implications for social policy. San Diego, Calif: Academic Press, 1998.

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9

Sirotkin, S. F. Zametki po metapsikhologii agressivnosti. Izhevsk: NIPT︠S︡ "ERGO", 2005.

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10

Čermák, Ivo. Lidská agrese a její souvislosti. Žd̕ár nad Sázavou: Fakta, 1998.

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Частини книг з теми "Aggressiveness"

1

Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, Marc N. Potenza, Tayfun Uzbay, Lisiane Bizarro, David C. S. Roberts, et al. "Aggressiveness." In Encyclopedia of Psychopharmacology, 45. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3029.

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Sink, Holli E. "Aggressiveness." In Encyclopedia of Cross-Cultural School Psychology, 102–4. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-0-387-71799-9_17.

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Carota, A., J. Bogousslavsky, and P. Calabrese. "Poststroke Aggressiveness." In Neuropsychiatric Symptoms of Neurological Disease, 161–88. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-2428-3_8.

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Furnham, Adrian. "Passive aggressiveness." In The Engaging Manager, 126–28. London: Palgrave Macmillan UK, 2012. http://dx.doi.org/10.1057/9781137273871_36.

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Baumeister, Roy F., and Brad J. Bushman. "Emotions and Aggressiveness." In International Handbook of Violence Research, 479–93. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-0-306-48039-3_25.

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Neill, Calum, and Tom Eyers. "Aggressiveness in psychoanalysis." In Reading Lacan’s Écrits, 152–74. London: Routledge, 2024. http://dx.doi.org/10.4324/9781003368649-7.

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Bös, Dieter, and Martin Kolmar. "Aggressiveness and Redistribution." In Steuerpolitik — Von der Theorie zur Praxis, 15–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55887-0_2.

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Levine, Richard N., and Nathan H. Levine. "Hatred and Aggressiveness." In Edward Conze's The Psychology of Mass Propaganda, 65–87. New York: Routledge, 2023. http://dx.doi.org/10.4324/9781003363408-6.

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Levine, Timothy R. "Verbal Aggressiveness Scale (VAS)." In The Sourcebook of Listening Research, 599–604. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119102991.ch68.

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Dana, Guy. "From violence to aggressiveness." In On Psychoanalysis and Violence, 137–47. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2018. http://dx.doi.org/10.4324/9780429437342-12.

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Тези доповідей конференцій з теми "Aggressiveness"

1

MacLaughlin, Thomas F. "Measurement of Frontal Aggressiveness." In SAE International Congress and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1986. http://dx.doi.org/10.4271/860205.

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2

"AGGRESSIVENESS AND ASSERTIVE BEHAVIOUR." In International Psychological Applications Conference and Trends. inScience Press, 2023. http://dx.doi.org/10.36315/2023inpact148.

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3

Yin Kuo, Chen. "BUSINESS STRATEGY, ACCOUNTING CONSERVATISM, TAX AGGRESSIVENESS." In MBP 2024 Singapore International Conference on Management & Business Practices, 13-14 March. Global Research & Development Services, 2024. http://dx.doi.org/10.20319/icbellp.209210.

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Анотація:
Different from literature studying the bi-variable relation between business strategy and accounting conservatism as well as tax aggressiveness, this research provides original ideas exploring the relation among business strategy and accounting conservatism through tax aggressiveness. Using the Taiwan data including high-technology and traditional industries, our results indicate that first, prospector companies are more tax aggressive, and are more accounting conservative than defender ones. Secondly, the positive effect of business strategy on accounting conservatism holds through increasing tax aggressiveness (reducing tax payment), implying prospector companies with more tax aggressiveness are more accounting conservatism than defender ones with less tax aggressiveness. Thirdly, the positive effect of strategy on conservatism through increasing tax aggressiveness in high-tech firms is stronger than that in traditional ones. This implies that compared to traditional firms, high-technology firms can more strengthen this positive effect through tax aggressiveness. Fourthly, this paper highlights the role of tax aggressiveness in driving association between business strategy and conservative accounting. Finally, our results are analogous to Higgins et al. (2015) and Hsieh et al. (2019)’s findings of U.S. sample companies, implying that some characteristics of Taiwan companies (e.g., access to capital market, tax deductibility of investment in R&D) appear to be similar to particularities of U.S. firms. This paper provides the evidence on a developing country (Taiwan) for investors and portfolio managers.
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Batic, Dragana. "AGGRESSIVE BEHAVIOUR AMONG CONVICTS IN THE PRISONS IN MACEDONIA." In SECURITY HORIZONS. Faculty of Security- Skopje, 2022. http://dx.doi.org/10.20544/icp.3.6.22.p19.

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This paper is a part of the research conducted in the prisons of the Republic of North Macedonia, under the title "The Position of Convicted Persons in Penitentiary Institutions in Macedonia". The topic refers to the psychological response of convicted persons to their stay in prison, and above all to aggressiveness and its connection with deprivations in prison. The purpose of the research was to determine the degree of aggressiveness and components of aggressiveness, as well as the connection of aggressiveness with deprivations in the prison population. The results showed that recidivists are not more aggressive than first-time convicts, but the aggressiveness of both is higher in relation to norms. Regarding the association of aggression with deprivations from prison, it has been shown that there is an association with deprivations of material goods, heterosexual relationships and freedom as a result of being in prison. In explaining these findings, we used the frustration theory of aggressiveness, according to which all forms of aggressiveness have their source in the frustration of behavior aimed at satisfying some relevant biological need. Based on this research, some recommendations are given for reducing aggressiveness. Key words: aggression, deprivations, prison, convicted persons, frustration
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Hirabayashi, Riku, Jose A. B. Fortes, and Saneyasu Yamaguchi. "Aggressiveness-Controllable Block-Level Cache." In 2021 Ninth International Symposium on Computing and Networking Workshops (CANDARW). IEEE, 2021. http://dx.doi.org/10.1109/candarw53999.2021.00080.

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6

Adiwahana, Agus, and Dwi Martani. "Analysis of Tax Aggressiveness and Financial Reporting Aggressiveness on Public Companies in Indonesia 2010-2014." In 6th International Accounting Conference (IAC 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/iac-17.2018.32.

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Martinelli, Fabio, Francesco Mercaldo, Vittoria Nardone, Albina Orlando, and Antonella Santone. "Cluster Analysis for Driver Aggressiveness Identification." In 2nd International Workshop on FORmal methods for Security Engineering. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0006755205620569.

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Irene Olivas and Arantxa Villagrá. "Aggressiveness Testing of Breeding Rabbit Does." In 2012 IX International Livestock Environment Symposium (ILES IX). St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2012. http://dx.doi.org/10.13031/2013.41599.

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Bremler-Barr, Anat, Nir Halachmi, and Hanoch Levy. "Protecting Bursty Applications Against Traffic Aggressiveness." In 200614th IEEE International Workshop on Quality of Service. IEEE, 2006. http://dx.doi.org/10.1109/iwqos.2006.250479.

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10

Smorkalova, Tatiana. "Social-Psychological Adaptation and Aggressiveness in Early Adolescence." In The Public/Private in Modern Civilization, the 22nd Russian Scientific-Practical Conference (with international participation) (Yekaterinburg, April 16-17, 2020). Liberal Arts University – University for Humanities, Yekaterinburg, 2020. http://dx.doi.org/10.35853/ufh-public/private-2020-46.

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Анотація:
The article contains empirical findings regarding the correlation between aggressiveness and social-psychological adaptation in adolescents. In today’s world, the issue of aggression and violence remains relevant. To date, the world has faced a complex situation due to economic, ecological, and social problems, which preconditions a rapid rise in human aggressive behaviour. The issue of aggressive behaviour is of particular urgency among adolescents. Many of the factors underlying aggression in adolescence have not yet been sufficiently substantiated in the scientific community. Such insufficiently studied phenomena include the correlation between aggressiveness and social-psychological adaptation. Social-psychological adaptation means a personal state allowing to attain mutual contentment of a person and social environment. Empirical findings have revealed a correlation between aggressiveness and social-psychological adaptation. It was found that the more aggression and its various forms are expressed, the more maladaptivity is manifested in young adolescents. However, positive associations were found between forms of aggression and components of adolescent socio- psychological adjustment. In this case, aggression can act as a compensating factor for maladaptation. Further studies of the correlation between aggressiveness and social-psychological adaptation comprises, firstly, research into gender differences in the correlation between aggressiveness and social-psychological adaptation, and secondly, studies in other ages and social groups of respondents.
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Звіти організацій з теми "Aggressiveness"

1

Cooney, Kathleen A. Prostate Cancer Aggressiveness Genes in Hereditary Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2005. http://dx.doi.org/10.21236/ada446359.

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Cooney, Kathleen A., and Colin Duckett. Prostate Cancer Aggressiveness Genes in Hereditary Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2006. http://dx.doi.org/10.21236/ada455279.

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3

Bock, Cathryn. MicroRNA in Prostate Cancer Racial Disparities and Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada613715.

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Sriram, Renuka, and Betty Diamond. Hyperpolarized 13C MR Markers of Renal Tumor Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada599542.

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Sriram, Renuka. Hyperpolarized 13C MR Markers of Renal Tumor Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada615065.

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Cooney, Kathleen. Prostate Cancer Aggressiveness Gene in Hereditary Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2007. http://dx.doi.org/10.21236/ada472110.

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D'Assoro, Antonino B. Centrosome Amplification: A Potential Marker of Breast Cancer Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, July 2004. http://dx.doi.org/10.21236/ada429622.

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Witte, John S. Relation of Genes to Prostate Cancer Occurrence and Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, July 1999. http://dx.doi.org/10.21236/ada374742.

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Hu, Chien-An. Mutations in PUMA Gene Cause Prostate Cancer Development and Aggressiveness. Fort Belvoir, VA: Defense Technical Information Center, November 2006. http://dx.doi.org/10.21236/ada456366.

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Yasmin-Karim, Sayeda. Microvascular Channel Device to Study Aggressiveness in Prostate Cancer Metastasis. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada606825.

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