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Добірка наукової літератури з теми "African trypanosomiasi"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "African trypanosomiasi"

Giblin, James. "Trypanosomiasis Control in African History: An Evaded Issue?" Journal of African History 31, no. 1 (March 1990): 59–80. http://dx.doi.org/10.1017/s0021853700024786.

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Social control of trypanosomiasis in African history deserves further study. The pioneering work in this field is John Ford's respected but neglected The Role of the Trypanosomiases in African Ecology (1971). While Ford's arguments have received support from recent findings in immunological, epidemiological and epizootiological research, they have rarely met with evaluation or engagement, either in historical or scientific literature. Historians have tended to describe trypanosomiasis control as a matter of avoiding contact with tsetse fly. In so doing they have implicitly rejected the position of Ford, who regarded infrequent contacts between tsetse and mammalian hosts as necessary for the maintenance of host resistance. Ford believed that host resistance, rather than avoidance of tsetse, was the basis of trypanosomiasis control. The historical nature of Ford's work requires that a satisfactory evaluation of The Role of the Trypanosomiases make use of historical, as well as scientific, data. The evidence of trypanosomiasis and cattle-keeping from one region of north-eastern Tanzania supports Ford and suggests that other explanations of trypanosomiasis control are inadequate. The Tanzanian evidence shows that precolonial societies coexisted with, but could not avoid, tsetse. They could not eradicate tsetse because scarcity of water prevented permanent occupation of large areas. Tsetse and trypanosomiasis did not prevent cattle-keeping, but helped to keep the region's cattle population low and confined it to relatively densely settled neighbourhoods. Social control of trypanosomiasis collapsed during the pre-Second World War period of colonial rule. Economic and political developments were primarily responsible for a series of famines between 1894 and 1934. Famine-induced depopulation allowed steady spread of tsetse and wildlife reservoirs of trypanosomes into formerly cultivated areas which had been free of tsetse before the colonial period.

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VICKERMAN, KEITH. "The Trypanosomiases (ed. Maudlin, I., Holmes, P. H. & Miles, M. A.), pp. 624. International CABI Publishing, UK, 2004. ISBN 0 85199 475 X. £99.50 (US$185.00)." Parasitology 131, no. 3 (August 16, 2005): 436–37. http://dx.doi.org/10.1017/s0031182005238581.

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Back in the early 1960s, when the curtain was falling on British colonial administration in Africa, the newly-created Ministry of Overseas Development decided to gather together for posterity the expertise and experience of authorities on tsetse and trypanosomiasis control. Weighing in at three and a half pounds, the resulting publication, ‘The African Trypanosomiases’ edited by Colonel Hugh Mulligan and published in 1969, has since been a baseline not only for investigators in the field but also for pure scientists working on related problems at the laboratory bench. The editors of the present volume were inspired by the enormous progress made in trypanosomiasis research over the last thirty years to produce ‘an update of Mulligan’ – so, how do the two books compare? Well, amazingly, their weights are exactly the same – but content and coverage are, as might be expected, very different.

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Pereira, Glaécia AN, Lucianna H. Santos, Steven C. Wang, Luan C. Martins, Filipe S. Villela, Weiting Liao, Marco A. Dessoy, et al. "Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei." Future Medicinal Chemistry 11, no. 13 (July 2019): 1537–51. http://dx.doi.org/10.4155/fmc-2018-0523.

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Aim: Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets for treatment of Chagas disease and human African trypanosomiasis. Previous studies reported a benzimidazole series as potent cruzain inhibitors. Results & methodology: Considering the high similarity between these proteases, we evaluated 40 benzimidazoles against rhodesain. We describe their structure-activity relationships (SAR), revealing trends similar to those observed for cruzain and features that lead to enzyme selectivity. This series comprises noncovalent competitive inhibitors (best Ki = 0.21 μM against rhodesain) and micromolar activity against Trypanosoma brucei brucei. A cheminformatics analysis confirms scaffold novelty, and the inhibitors described have favorable predicted physicochemical properties. Conclusion: Our results support this series as a starting point for new human African trypanosomiasis medicines.

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Morais, Mayara Castro de, Jucieudo Virgulino de Souza, Carlos da Silva Maia Bezerra Filho, Silvio Santana Dolabella, and Damião Pergentino de Sousa. "Trypanocidal Essential Oils: A Review." Molecules 25, no. 19 (October 6, 2020): 4568. http://dx.doi.org/10.3390/molecules25194568.

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Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.

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Parwan, Deepika, Ranjan Kumar, and Sumit Aggrawal. "African Trypanosomiasis in Young Female in North India - A Rare Case Report." Annals of Pathology and Laboratory Medicine 8, no. 4 (May 10, 2021): C71–73. http://dx.doi.org/10.21276/apalm.2997.

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Human African trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease. It is caused by infection with protozoan parasites belonging to the genus Trypanosoma. They are transmitted to humans by tsetse fly (Glossina genus) bites which have acquired their infection from human beings or from animals harboring human pathogenic parasites. Tsetse flies are found just in sub-Saharan Africa though only certain species transmit the disease. We report a case of human African trypanosomiasis in a 28-year-old Indian female who had a travel history to sub–Saharan Africa, Uganda and she presented with a history of fever, body ache, headache, decreased oral intake, pain lower abdomen, swelling and discharge from forearm chancre since last 4-5 days. Peripheral smear showed heavy parasitemia by flagellated forms of Trypanosoma and the diagnosis of Trypanosoma brucei was given on Peripheral smear report. Serological testing was also done and a diagnosis of West-African trypanosomiasis was confirmed. The patient was successfully treated and made a good recovery. So West-African trypanosomiasis should be considered in the differential diagnosis with presentation of fever with chancre in every person with recent history of travel to African countries as it is universally fatal without treatment.

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Mulenga, Gloria M., Lars Henning, Kalinga Chilongo, Chrisborn Mubamba, Boniface Namangala, and Bruce Gummow. "Insights into the Control and Management of Human and Bovine African Trypanosomiasis in Zambia between 2009 and 2019—A Review." Tropical Medicine and Infectious Disease 5, no. 3 (July 11, 2020): 115. http://dx.doi.org/10.3390/tropicalmed5030115.

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Tsetse transmitted trypanosomiasis is a fatal disease commonly known as Nagana in cattle and sleeping sickness in humans. The disease threatens food security and has severe economic impact in Africa including most parts of Zambia. The level of effectiveness of commonly used African trypanosomiasis control methods has been reported in several studies. However, there have been no review studies on African trypanosomiasis control and management conducted in the context of One Health. This paper therefore seeks to fill this knowledge gap. A review of studies that have been conducted on African trypanosomiasis in Zambia between 2009 and 2019, with a focus on the control and management of trypanosomiasis was conducted. A total of 2238 articles were screened, with application of the search engines PubMed, PubMed Central and One Search. Out of these articles, 18 matched the required criteria and constituted the basis for the paper. An in-depth analysis of the 18 articles was conducted to identify knowledge gaps and evidence for best practices. Findings from this review provide stakeholders and health workers with a basis for prioritisation of African trypanosomiasis as an important neglected disease in Zambia and for formulation of One Health strategies for better control and/or management of the disease.

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Torr, S. J., G. A. Vale, and J. F. Morton. "Less is more: restricted application of pyrethroids for controlling tsetse." Proceedings of the British Society of Animal Science 2005 (2005): 31. http://dx.doi.org/10.1017/s175275620000942x.

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In Africa, the animal trypanosomiases kill about 3 million cattle each year with related annual losses in animal productivity of ∼£3 billion. 32 of the 36 affected countries have per capita incomes of less than US$1 per day. The most effective method of combating the trypanosomiases is to eradicate their vectors, the tsetse. Up to the early 1980s, responsibility for vector control in Africa was largely taken by government agencies, using techniques such as large-scale aerial and ground spraying. Following economic crises, structural adjustment and decline or privatisation of veterinary services, much of the onus for controlling tsetse has fallen on livestock keepers themselves (Eisler et al. 2003), but partly as a consequence of trypanosomiasis, many are too poor to afford the cost. Treating cattle with synthetic pyrethroids may provide a way of breaking this cycle of poverty and disease.

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Taylor, Emma Michelle, and James Smith. "Product Development Partnerships: Delivering Innovation for the Elimination of African Trypanosomiasis?" Tropical Medicine and Infectious Disease 5, no. 1 (January 15, 2020): 11. http://dx.doi.org/10.3390/tropicalmed5010011.

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African trypanosomiasis has been labelled as a ‘tool-deficient’ disease. This article reflects on the role that Product Development Partnerships (PDPs) have played in delivering new tools and innovations for the control and elimination of the African trypanosomiases. We analysed three product development partnerships—DNDi, FIND and GALVmed—that focus on delivering new drugs, diagnostic tests, and animal health innovations, respectively. We interviewed key informants within each of the organisations to understand how they delivered new innovations. While it is too early (and beyond the scope of this article) to assess the role of these three organisations in accelerating the elimination of the African trypanosomiases, all three organisations have been responsible for delivering new innovations for diagnosis and treatment through brokering and incentivising innovation and private sector involvement. It is doubtful that these innovations would have been delivered without them. To varying degrees, all three organisations are evolving towards a greater brokering role, away from only product development, prompted by donors. On balance, PDPs have an important role to play in delivering health innovations, and donors need to reflect on how best to incentivise them to focus and continue to deliver new products.

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Maudlin, I. "African trypanosomiasis." Annals of Tropical Medicine & Parasitology 100, no. 8 (December 2006): 679–701. http://dx.doi.org/10.1179/136485906x112211.

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MORRISON, L. J., and A. MacLEOD. "African trypanosomiasis." Parasite Immunology 33, no. 8 (July 15, 2011): 421–22. http://dx.doi.org/10.1111/j.1365-3024.2011.01302.x.

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Дисертації з теми "African trypanosomiasi"

Rossi, B. C. "Macrophage function in African trypanosomiasis." Thesis, Brunel University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373784.

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Milligan, Paul. "Population dynamics of African trypanosomiasis." Thesis, University of Salford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306017.

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Bailey, Wendi. "The diagnosis of human African trypanosomiasis." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260319.

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Hublart-Sinsoillier, Marylène. "Hypogonadisme et trypanosomiase africaine." Lille 1, 1989. http://www.theses.fr/1989LIL10127.

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Parmi les éléments cliniques et biologiques caractérisant la maladie du sommeil, l'apparition d'un hypogonadisme représente un élément de grande fréquence. Notre possibilité de réaliser des explorations, par des dosages radioimmunologiques des hormones sexuelles sur un nombre significatif de malades infectes par trypanosoma brucei gambiense, a permis de mesurer l'importance du dysfonctionnement endocrinien. Par des explorations dynamiques de l'axe gonadotrope, une origine supra ou extra hypophysaire à l'hypogonadisme peut être évoquée. L'adaptation sur le modèle animal, nous a permis d'explorer dans son ensemble l'axe hypothalamo hypophyso gonadotrope du rat infesté par trypanosoma brucei brucei. Parmi les résultats originaux seront soulignés : l'effet in vivo, de l'antigène variable de surface (VSG) qui entraine une hyposécrétion de testostérone accompagnée d'une diminution de synthèse de l'hormone lutéinisante hypophysaire (LH). L'effet in vitro d'extraits parasitaires préparés en présence ou en absence d'antiprotéases qui provoquent une dissociation de la LH en ses deux sous unités libres ou une dégradation plus complète de la gonadostimuline. A la lumière de ces résultats, différentes hypothèses physiopathologéniques de l'hypogonadisme sont présentées. Sans conteste, le rôle des constituants membranaires de surface du trypanosome dans la relation hôte-parasite est mis en évidence.

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Kashiwazaki, Yoshihito. "A new immunodiagnosis for African trypanosomiases." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359033.

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Kroubi, Maya. "Développement de formulations colloïdales antiparasitaires pour traiter la trypanosomiase africaine." Thesis, Lille 2, 2010. http://www.theses.fr/2010LIL2S043/document.

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Cette thèse porte sur le développement d’une formulation colloïdale de diminazène (DMZ) à l’aide de nanoparticules polysaccharidiques cationiques (NP+) pour le traitement de la Trypanosomiase Africaine (TA).Nous avons étudié dans un premier temps le procédé de chargement des NP+ en DMZ base. Nous avons constaté que l’ajout de phospholipides dans la matrice des NP+ est nécessaire à l’association de DMZ. La quantité de phospholipide est d’ailleurs le facteur limitant de l’indice de saturation des NP+ en DMZ. Afin de ne pas dégrader le principe actif, lors de son chargement, le procédé choisi est le « post-loading » qui correspond à un mode opératoire en conditions douces : ajout d’une solution de DMZ dans une suspension de NP+ à cœur huileux. Nos résultats montrent que cette formulation reste stable durant 6 mois à 4°C ne libérant pas de DMZ et le protégeant de l’oxydation. Dans un second temps, nous avons évalué l’efficacité thérapeutique du DMZ formulé. Les tests in vitro sur Trypanosoma brucei brucei montrent une amélioration de l’activité trypanocide du DMZ. Les tests réalisés sur un modèle aigu de TA, ont mis en évidence que la dose efficace est équivalente au DMZ libre (3 mg/kg)
This thesis focuses on the development of a colloidal formulation of diminazene (DMZ) using cationic polysaccharide nanoparticles (NP+) for the treatment of African Trypanosomiasis. We first studied the process of DMZ loading in NP+. The addition of phospholipids in the matrix of the NP+ appeared to be necessary for the DMZ association. So, the amount of phospholipids is the limiting factor of the saturation index of NP+ with DMZ. To avoid the drug degradation during its formulation, we choose the \\\"post-loading\\\" technique which corresponds to a procedure with mild conditions: adding a DMZ solution in a suspension of NP+ containing an oily core. DMZ loaded into 70DGNP+ was found to be protected against oxidation and was stable for at least 6 months at 4°C. In a second step, we evaluated the therapeutic efficacy of formulated DMZ. In vitro tests on Trypanosoma brucei brucei showed an improvement of the DMZ trypanocidal activity. Tests on an acute model of Trypanosomiasis showed that the effective dose is equivalent to the free DMZ (3 mg / kg)

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Hoste, Christian. "Elevage et trypanosomiase animale africaine." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37605971k.

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Matemba, Lucas E. "Epidemiology of human African trypanosomiasis in western Tanzania." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/24915.

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This thesis started by reviewing the existing sleeping sickness historical records in Tanzania with the aim of exploring the evidence for the existence of Trypanosoma brucei gambiense in Tanzania. Findings from the available historical data did not provide sufficient evidence for the existence of T. b. gambiense sleeping sickness in Tanzania.
The thesis further estimated under-reporting of T. b. rhodesiense in endemic areas of Tanzania using an established model. Using data from a 2000-2004 outbreak of T. b. rhodesiense in Urambo, the model predicts 46% underreporting. All unreported cases were assumed to be undetected deaths as sleeping sickness is invariable fatal if left untreated. These underreporting findings were then used to recalibrate the burden of T. b. rhodesiense (using Disability-Adjusted Life Years – DALYs), as a metric. The burden imposed to rural communities by rhodesiense sleeping sickness is high. The costs of hospitalization are very high considering the long duration of hospital stay (26 days mean hospital stay) for sleeping sickness patients. Finally the thesis investigated spatial and behavioural risk factors for T. b. rhodesiense sleeping sickness in Urambo district, through a matched case control study both at the village and within village scales. Statistically significant cluster was observed at the village level (P = 0.001). However there was no significant spatial association in an individual village’s analysis. There was an increased risk of sleeping sickness in homesteads with a previous history of the disease (P < 0.001). Presence of wild animals in the villages (P<0.001) and forest visits (P = 0.001) were also significantly associated with sleeping sickness in the district.

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Felu, Cécile. "Characterisation of the mechanism of human serum resistance in T.b.gambiense." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210844.

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The two human pathogenic sub-species T.b.gambiense and T.b.rhodesiense can be distinguished from the morphologically identical T.b.brucei by their ability to infect humans, enabling them to cause sleeping sickness. This is because they are resistant to lysis by the lytic factor (APOL-I) present in normal human serum (NHS). In T.b.rhodesiense resistance to this lytic factor is due to a truncated VSG gene termed SRA which blocks lysis by interacting with APOL-I in the lysosome. SRA does not exist in T.b.gambiense. The search for a similar truncated VSG gene lead to the identification of a T.b.gambiense specific glycoprotein termed TGSGP. TGSGP transfected alone into the sensitive T.b.brucei is unable to confer resistance to this sub-species. This is either due to incorrect processing of this gene is this sub-species or because TGSGP requires a partner to confer resistance.

In the search for a partner, the genomic locus of TGSGP was cloned and sequenced. We found that TGSGP is linked to a truncated gene homologous to the S.cerevisiae AUT1 gene, a gene implicated in autophagy and more specifically in membrane expansion. Southern blot hybridization and PCR analysis on genomic DNA from several isolates demonstrated that this feature was a specific to T.b.gambiense. In addition, we observed a correlation between the aut1 allele size and the geographical origin of the isolate.

Since in trypanosomes lysis by NHS is due to an uncontrolled expansion of the lysosome, we speculated that the truncation of the aut1 allele could be implication in the resistance to human serum. We characterized the genomic organisation of the AUT1 locus. T.b.brucei possesses two native AUT1 alleles whilst T.b.gambiense possesses a truncated aut1 allele, as well as a native AUT1 allele. We showed that in the T.b.gambiense LiTAR isolate (aut1/AUT1), despite the presence of a wild-type allele this gene is no longer expressed at the mRNA and protein level. Our complimentary results by run-on transcription assay showed that the AUT1 region is transcribed but that the messenger is unstable. LiTAR is a functional knock-out for AUT1, but Northern blot analysis on several T.b.gambiense isolates showed that this is not a generalised T.b.gambiense characteristic.

We explored the role of AUT1 in trypanosomes by invalidation of the AUT1 gene in T.b.brucei and by the over-expression of the AUT1 and aut1 alleles in T.b.brucei. By functional analysis of AUT1 knocked-down cells we showed that AUT1 is not essential in trypanosomes. By recreating in T.b.brucei the T.b.gambiense AUT1/aut1 genotype we were able to show that the expression of the aut1 UTR down-regulated the expression of the wild-type AUT1 allele. We speculated that this may be due to a natural RNAi mechanism. Par northern blot, using probes covering the potential target region of AUT1, we detected a 50nt small RNA specific to T.b.gambiense. In addition, we showed that in a LiTAR strain in which the RNAi pathway was abolished AUT1 expression is restored.

We continued to investigate TGSGP’s role in the resistance to human serum by invalidation of TGSGP in T.b.gambiense and by expressing TGSGP in the NHS-sensitive T.b.brucei. Because T.b.gambiense cannot be cultured in vitro we established a new in vivo transfection technique and as the knock-out of TGSGP is most probably lethal, we created an inducible RNAi T.b.gambiense cell strain. These indispensable tools will be used to test whether invalidation TGSGP is sufficient to confer resistance to NHS. Many strategies were tested in order to correctly expressing TGSGP in T.b.brucei; in none of these transfectants was TGSGP correctly located in the flagellar pocket as is the case in T.b.gambiense and only partial resistance was ever obtained. In order to identify the factors in human serum that could interacts with TGSGP, we subjected NHS to affinity chromatography using TGSGP as bait. We showed that TGSGP interacts with APOA-I, a major component of HDLs.

Doctorat en sciences, Spécialisation biologie moléculaire
info:eu-repo/semantics/nonPublished

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au, ngiles@anhb uwa edu, and Natalie Giles. "Exploitation of the Protein Tubulin For Controlling African Trypanosomiasis." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060315.191003.

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This thesis presents the results of an investigation into the structural protein, tubulin, as a potential target for anti-trypanosomatid drug discovery and vaccine development. Recombinant alpha- and beta- tubulin proteins from Trypanosoma brucei rhodesiense were expressed as soluble fusion proteins in an E. coli expression system. The recombinant alpha- and beta- tubulins were used to determine the nature of binding of novel trifluralin analogues EPL-AJ 1003, 1007, 1008, 1016 and 1017. Native tubulin from rats was used to determine the extent of binding to mammalian tubulin. The results of this study clearly demonstrate two important aspects of the binding of trifluralins to tubulin. Firstly, they have specific affinity for trypanosomal tubulin compared with mammalian regardless of the chemical composition of the trifluralin analogue tested. Secondly, they have a demonstrably stronger affinity for alpha-tubulin compared with beta-tubulin. In addition, compounds 1007, 1008, 1016 and 1017 have strong binding affinities for alpha-tubulin, with limited binding affinity for mammalian tubulin, which indicates that these compounds selectively bind to trypanosomal tubulin. The morphology of bloodstream forms of T. b. rhodesiense exposed to trifluralin analogues was studied using electron microscopy and immunofluorescence to determine the ultrastructural changes these compounds induce as a result of binding to tubulin. All compounds tested induced severe irreparable damage in T. b. rhodesiense, including perturbation of subpellicular microtubules, extensive cytoplasmic swellings, axoneme and paraflagellar rod malformation, disconfiguration around the flagellar pocket and membrane disintegration. These results suggest that the mechanism of action of these trifluralin analogues is through the disruption of polymerization of tubulin into microtubules as a result of binding to alpha-tubulin. The potential for recombinant trypanosomal tubulins to be used as vaccine candidates was assessed by monitoring parasitaemia and length of survival of mice immunised with the proteins and challenged with a lethal infection of T. b. rhodesiense. Although all the mice vaccinated with recombinant tubulin developed a patent parasitaemia and did not survive, they were partially protected because their patency period and length of survival were significantly greater than the control groups. Furthermore, plasma collected from mice immunised with recombinant trypanosomal tubulin contained antibodies that recognized tubulin in a soluble extraction from T. b. rhodesiense. The results of this thesis confirm the potential for the structural protein, tubulin, to be used as a target for anti-trypanosomatid drug discovery and vaccine development.

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Більше джерел

Книги з теми "African trypanosomiasi"

Desta, Abeba. Trypanosomiasis and tsetse flies (1907-1979) =: Les trypanosomiases et les glossines (1907-1979). Addis Ababa, Ethiopia: Documentation Centre, International Livestock Centre for Africa, 1988.

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G, Hide, ed. Trypanosomiasis and leishmaniasis: Biology and control. Wallingofrd, Oxon, UK: CAB International, 1997.

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Milligan, Paul. Population dynamics of African Trypanosomiasis. Salford: University of Salford, 1991.

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Rossi, Bartira Consini. Macrophage function in African trypanosomiasis. Uxbridge: Brunel University, 1986.

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1947-, Black Samuel J., and Seed J. Richard 1937-, eds. The African trypanosomes. Boston: Kluwer Academic Publishers, 2001.

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Trypanosomiasis control and African rural development. London: Longman, 1986.

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Swallow, Brent M. Impacts of trypanosomiasis on African agriculture. Rome: Food and Agriculture Organization of the United Nations, 2000.

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Jordan, Anthony M. Trypanosomiasis control and African rural development. London: Longman, 1986.

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Dumas, Michel, Bernard Bouteille, and Alain Buguet, eds. Progress in Human African Trypanosomiasis, Sleeping Sickness. Paris: Springer Paris, 1999. http://dx.doi.org/10.1007/978-2-8178-0857-4.

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1934-, Dumas Michel, Bouteille Bernard 1952-, and Buguet Alain, eds. Progress in human African trypanosomiasis, sleeping sickness. Paris: Springer, 1999.

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Частини книг з теми "African trypanosomiasi"

Namangala, Boniface, and Steven Odongo. "Animal African Trypanosomosis in Sub-Saharan Africa and Beyond African Borders." In Trypanosomes and Trypanosomiasis, 239–60. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1556-5_10.

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Long, E. G. "African Trypanosomiasis." In Laboratory Diagnosis of Infectious Diseases, 731–38. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3898-0_75.

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Mehlhorn, Heinz. "African Trypanosomiasis." In Encyclopedia of Parasitology, 68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_84.

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Magez, Stefan, Hang Thi Thu Nguyen, Joar Esteban Pinto Torres, and Magdalena Radwanska. "African Trypanosomiasis." In Textbook of parasitic zoonoses, 125–38. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7204-0_12.

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Mehlhorn, Heinz. "African Trypanosomiasis." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_84-2.

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Warren, Kenneth S., and Adel A. F. Mahmoud. "African Trypanosomiases." In Geographic Medicine for the Practitioner, 99–105. New York, NY: Springer New York, 1985. http://dx.doi.org/10.1007/978-1-4613-8578-3_15.

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Büscher, Philippe. "Diagnosis of African Trypanosomiasis." In Trypanosomes and Trypanosomiasis, 189–216. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1556-5_8.

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Pépin, Jacques, and Honoré Méda. "Human African Trypanosomiasis." In Antimicrobial Drug Resistance, 1113–19. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-595-8_30.

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Domachowske, Joseph, and Manika Suryadevara. "African Sleeping Sickness: African Trypanosomiasis." In Clinical Infectious Diseases Study Guide, 307–11. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50873-9_50.

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Spinage, Clive A. "The Trypanosomiases I." In African Ecology, 915–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22872-8_19.

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Тези доповідей конференцій з теми "African trypanosomiasi"

"Targeting peroxisomal transport in trypanosoma." In 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022). Cihan University, 2022. http://dx.doi.org/10.24086/biohs2022/paper.566.

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Human infection with Trypanosoma parasites (Chagas disease and Human African Trypanosomiasis) affects around 10 million people worldwide resulting in life-threatening disease. Treatment options are limited to historic drugs characterized by significant side effects and decreasing efficacy while new drug development efforts are largely neglected. Here, we review drug discovery effort in human trypanosomiasis undertaken in academia. Peroxisomal (Pex) transport system was validated as a target in Chagas disease and a number of compounds were delivered which have shown promising results in animal experiments. Future perspectives of exploring the Pex system in anti-trypanosoma drug development are discussed.

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W. Bradosty, Sarwan, Ahmad K. Maigari, Nasir T. Dabo, and Salisu Ibrahim. "Application of Body Condition Scorings to Effective Detection of African Trypanosomiasis in Camels and Cattle." In 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022). Cihan University, 2022. http://dx.doi.org/10.24086/biohs2022/paper.709.

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Trypanosomiasis is a parasitic disease that is transmitted by tsetse flies. However, because of the limitation of conventional parasitological methods, conclusive epidemiological inferences on trypanosomiasis is challenging, leaving a high proportions of the disease to remain undetected which leads to difficulty in monitoring and strategic control. The present study therefore, employed the use of molecular methods to detect trypanosomes in trade camels and cattle, along line analysis of their body condition scores (BCS). Results of the study indicated that, all the infected camels and majority of the infected cattle had poor BCS. The average packed cell volume (PCV) of infected animals was lower than the average PCV of uninfected animals. Findings from this study revealed an infection rate of 48.75% with the most frequently encountered species being Trypanosoma vivax (18.75%), followed by T. brucei (12.50%), T. congolense (8.75%), T. evansi (6.25%) and mixed infection involving T. brucei and T. congolense (2.50%). Conclusively, animals with poor BCS are more susceptible suggesting that, the use of BCS may improve the quality of evaluation of trypanosomiasis in animals, especially for large scale epidemiological study.

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"Antimalarial, Anti-trypanosomiasis, Anti-HIV and Cytotoxicity Studies of Some Ferrocenyl Schiff bases." In Nov. 27-28, 2017 South Africa. EARES, 2017. http://dx.doi.org/10.17758/eares.eap1117039.

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MADSEN, T., D. I. WALLACE, and N. ZUPAN. "SEASONAL FLUCTUATION IN TSETSE FLY POPULATIONS AND HUMAN AFRICAN TRYPANOSOMIASIS: A MATHEMATICAL MODEL." In International Symposium on Mathematical and Computational Biology. WORLD SCIENTIFIC, 2013. http://dx.doi.org/10.1142/9789814520829_0004.

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Dardonville, Christophe, Francisco José Fueyo González, Carolina Izquierdo García, Teresa Díaz Ayuga, Godwin Ebiloma, Emmanuel Balogun, Kiyoshi Kita, and Harry de Koning. "Targeting the Trypanosome Alternative Oxidase (TAO) as Promising Chemotherapeutic Approach for African Trypanosomiasis." In 3rd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04641.

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Maseleno, Andino, Md Mahmud Hasan, Norjaidi Tuah, Fauzi, and Muhammad Muslihudin. "Fuzzy Logic and Dempster-Shafer belief theory to detect the risk of disease spreading of African Trypanosomiasis." In 2015 Fifth International Conference on Digital Information Processing and Communications (ICDIPC). IEEE, 2015. http://dx.doi.org/10.1109/icdipc.2015.7323022.

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Звіти організацій з теми "African trypanosomiasi"

Clarkson, Allen B., and Jr. Development of a New Chemotherapy for Human African Trypanosomiasis by Using an Animal Model: Suramin with DL-Alpha-Difluoromethylornithine. Fort Belvoir, VA: Defense Technical Information Center, September 1989. http://dx.doi.org/10.21236/ada237231.

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