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Статті в журналах з теми "111201 Cancer Cell Biology"
Muffly, Lori S., Qian Li, Elysia Alvarez, Justine M. Kahn, Lena E. Winestone, Rosemary Cress, Dolly Penn, and Theresa H. M. Keegan. "Hematopoietic Cell Transplantation in First Remission Amongst Adolescent and Young Adult Acute Lymphoblastic Leukemia: A Population-Level Analysis across the United States." Blood 132, Supplement 1 (November 29, 2018): 3965. http://dx.doi.org/10.1182/blood-2018-99-111205.
Повний текст джерелаOsman, Afaf, Brian Yu, Nancy Glavin, Tamar S. Polonsky, James K. Liao, and Richard A. Larson. "ABL Tyrosine Kinase Inhibitors (TKIs) Are Associated with Increased Rho-Associated Kinase (ROCK) Activity That May Contribute to Vascular Toxicity in Patients with Chronic Myeloid Leukemia (CML)." Blood 132, Supplement 1 (November 29, 2018): 1739. http://dx.doi.org/10.1182/blood-2018-99-111201.
Повний текст джерелаZelenkova, N. P. "Cancer cell biology." Kazan medical journal 43, no. 6 (October 19, 2021): 74–76. http://dx.doi.org/10.17816/kazmj83368.
Повний текст джерелаBebber, Christina M., Fabienne Müller, Laura Prieto Clemente, Josephine Weber, and Silvia von Karstedt. "Ferroptosis in Cancer Cell Biology." Cancers 12, no. 1 (January 9, 2020): 164. http://dx.doi.org/10.3390/cancers12010164.
Повний текст джерелаColaco, Camilo A. L. S. "Cancer immunotherapy: simply cell biology?" Trends in Molecular Medicine 9, no. 12 (December 2003): 515–16. http://dx.doi.org/10.1016/j.molmed.2003.10.006.
Повний текст джерелаRay, L. B. "Cancer Cell Vulnerability." Science Signaling 4, no. 202 (December 6, 2011): ec338-ec338. http://dx.doi.org/10.1126/scisignal.4202ec338.
Повний текст джерелаKroemer, Guido. "Tetraploid cancer cell precursors." Nature Reviews Molecular Cell Biology 11, no. 8 (June 23, 2010): 539. http://dx.doi.org/10.1038/nrm2924.
Повний текст джерелаMomeny, Majid, Tiina Arsiola, and Jukka Westermarck. "Cancer stem cell phosphatases." Biochemical Journal 478, no. 14 (July 28, 2021): 2899–920. http://dx.doi.org/10.1042/bcj20210254.
Повний текст джерелаRay, L. B. "Fueling the Cancer Cell." Science Signaling 3, no. 122 (May 18, 2010): ec153-ec153. http://dx.doi.org/10.1126/scisignal.3122ec153.
Повний текст джерелаNishino, Hiroshi. "Interleukin-6 affects cancer cell biology." Journal of Japan Society of Immunology & Allergology in Otolaryngology 34, no. 1 (2016): 13–18. http://dx.doi.org/10.5648/jjiao.34.13.
Повний текст джерелаДисертації з теми "111201 Cancer Cell Biology"
Bair, Elisabeth Laurine. "Cell-cell and cell-matrix interactions involved in cancer invasion." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280673.
Повний текст джерелаKrubasik, Davia Regina Editla. "The role of Metalloproteinases in cancer cell biology." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612722.
Повний текст джерелаNg, Sheng Rong. "CRISPR-mediated interrogation of small cell lung cancer." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117782.
Повний текст джерелаThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged student-submitted from PDF version of thesis. Vita.
Includes bibliographical references.
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine lung carcinoma that remains among the most lethal of solid tumor malignancies. Despite decades of research, treatment outcomes for SCLC remain very poor, highlighting the need for novel approaches to target the disease. Recent genomic sequencing studies have identified multiple recurrently altered genes in human SCLC tumors, many of which remain to be functionally validated. Genetically engineered mouse models (GEMMs) of SCLC have been developed that recapitulate many key features of human SCLC. These models have been used extensively to investigate various aspects of SCLC biology, including tumor initiation, progression and metastasis. The development of the CRISPR-Cas9 system has greatly facilitated genome editing in mammalian cells, leading to its widespread adoption for various applications in cancer biology. We have utilized this system in two complementary ways to investigate the molecular mechanisms involved in SCLC initiation, progression and maintenance. Firstly, we have adapted the CRISPR-Cas9 system for use in GEMMs of SCLC, to enable rapid modeling and functional validation of candidate tumor suppressor genes in vivo. Using this system, we have demonstrated that p107, a member of the retinoblastoma family that is mutated in a significant fraction of human SCLC tumors, is a functional tumor suppressor in SCLC. Notably, loss of p107 in SCLC tumors resulted in significant phenotypic differences compared with loss of its close relative, p130. We also demonstrated that CRISPR-induced mutations can be used to infer lineage relationships between primary and metastatic tumors in the same animal. Secondly, we have performed a CRISPR-based genetic screen, utilizing a custom sgRNA library targeting the druggable genome, to identify novel SCLC-specific genetic vulnerabilities. We found that SCLC cells displayed enhanced sensitivity towards disruption of several key metabolic pathways, including the de novo pyrimidine biosynthesis pathway. Pharmacological inhibition of Dhodh, a key enzyme in this pathway, reduced the viability of SCLC cells in vitro and strongly suppressed SCLC tumor growth in vivo, validating this pathway as a promising therapeutic target in SCLC. Taken together, the work presented here demonstrates the utility of the CRISPR-Cas9 system for performing functional interrogation of SCLC.
by Sheng Rong Ng.
Ph. D.
Kay, Sophie Kate. "Cell fate mechanisms in colorectal cancer." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f19bf73d-0c0e-4fff-9589-bf43f9ff12f0.
Повний текст джерелаNeal, Corey Lekeil. "Snail mediates epithelial mesenchymal transition and cell adhesion in human prostate cancer cell lines." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2011. http://digitalcommons.auctr.edu/dissertations/233.
Повний текст джерелаMcNae, Fiona. "The cell biology of non-genotoxic hepatocarcinogens." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260350.
Повний текст джерелаWeitzel, Douglas H. "Modulation of cell cycle checkpoints by anti-cancer agents /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu148820531851081.
Повний текст джерелаHorlock, Nigel. "The cell biology of basal cell carcinoma : relationship to histology and clinical outcome." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391606.
Повний текст джерелаPoluri, Raghavendra Tejo Karthik. "Using bioinformatic analyses to understand prostate cancer cell biology." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/66803.
Повний текст джерелаProstate Cancer (PCa) affects 1 in 7 men in their lifetime and is the number one diagnosed cancer in men. It is the 4th most common cancer in Canada. PCa is a hormone-dependent disease diagnosed in men. Androgens play a vital role in the disease progression. The standard of care to treat PCa, following surgery or radiation therapy, is the androgen deprivation therapy (ADT). In spite of initial positive response to androgen inhibition, the progression of the disease to castration-resistant prostate cancer (CRPC) is almost inevitable. Across the various stages of PCa, the androgen receptor (AR) plays a major role. This thesis portrays the methods developed and used to understand PCa biology. The work demonstrated in this thesis majorly consists of bioinformatic analyses performed on publicly available data sets and a pipeline built to analyse RNA-Seq data. An RNA-Seq pipeline has been developed to understand the impact of androgens and the genes regulated upon androgen treatment in PCa cell models. This bioinformatic pipeline consists of various tools which have been described below in chapter 1. The major goal of this project was to develop a pipeline to analyse the RNA-Seq data which helps to understand and define the metabolic pathways and genes regulated by androgens which play an important role in PCa disease progression. The experimental workflow consisted of two androgen receptor positive cell lines LNCaP and LAPC4. All the data used in this project has been made publicly available for the research community to perform various other comparative studies and analyses to understand the functions of androgens in a much deeper sense to develop novel therapies to treat PCa. In another project described in chapter 2, bioinformatic analyses have been performed on publicly available data to understand the loss and genomic alteration frequency of the gene PTEN occurring at 10q23. These analyses highlighted that the genomic alteration frequency of PTEN is much higher in CRPC than in localised PCa, and also helped in identifying other genes which are lost along with PTEN. The lost genes have not been studied much in literature, but few studies demonstrated that they might possess tumor suppressor characteristics. These results might be a good start for further deeper analyses regarding the lost of genes. Understanding the functions of AR and the deletion of PTEN will help for the development of novel strategies and approaches to diagnose and treat PCa. Integration of bioinformatic analyses with clinical research open up a new perspective in the PCa research domain.
Popovic, Predrag. "Cisplatin resistance in nonsmall cell lung cancer: Role of platinum accumulation and cell membranes." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/9662.
Повний текст джерелаКниги з теми "111201 Cancer Cell Biology"
Christian, Sherri L., ed. Cancer Cell Biology. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2376-3.
Повний текст джерелаCancer biology. 3rd ed. New York: Oxford University Press, 1995.
Знайти повний текст джерелаCancer biology. 2nd ed. New York: Oxford University Press, 1987.
Знайти повний текст джерелаCancer biology. 4th ed. Oxford: Oxford University Press, 2007.
Знайти повний текст джерелаFior, Rita, and Rita Zilhão, eds. Molecular and Cell Biology of Cancer. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11812-9.
Повний текст джерелаScatena, Roberto, Alvaro Mordente, and Bruno Giardina, eds. Advances in Cancer Stem Cell Biology. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-0809-3.
Повний текст джерелаScatena, Roberto, Alvaro Mordente, and B. Giardina. Advances in cancer stem cell biology. New York: Springer, 2012.
Знайти повний текст джерелаSchatten, Heide. Cell and molecular biology of breast cancer. New York: Humana Press, 2013.
Знайти повний текст джерела1939-, Wilson Samuel H., and Hoagland Mahlon B, eds. Cancer biology and biosynthesis. Boca Raton, Fla: CRC Press, 1991.
Знайти повний текст джерелаSchatten, Heide, ed. Cell and Molecular Biology of Breast Cancer. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-634-4.
Повний текст джерелаЧастини книг з теми "111201 Cancer Cell Biology"
Acconcia, Filippo, and Rakesh Kumar. "Cell Biology." In Encyclopedia of Cancer, 1–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_992-2.
Повний текст джерелаAcconcia, Filippo, and Rakesh Kumar. "Cell Biology." In Encyclopedia of Cancer, 892–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46875-3_992.
Повний текст джерелаHamerlik, Petra. "Cancer Stem Cells and Glioblastoma." In Glioma Cell Biology, 3–22. Vienna: Springer Vienna, 2014. http://dx.doi.org/10.1007/978-3-7091-1431-5_1.
Повний текст джерелаRibatti, Domenico, and Enrico Crivellato. "Mast Cells, Angiogenesis and Cancer." In Mast Cell Biology, 270–88. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9533-9_14.
Повний текст джерелаEnderling, Heiko. "Cancer Stem Cell Kinetics." In Encyclopedia of Systems Biology, 193–95. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1386.
Повний текст джерелаSantra, Debarpita. "Cell Biology and Cell Behavior in Cancer." In Cancer Diagnostics and Therapeutics, 13–41. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-4752-9_2.
Повний текст джерелаHann, Christine L. "Small Cell Lung Cancer: Biology Advances." In Lung Cancer, 197–211. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-74028-3_9.
Повний текст джерелаBarata, João T., and Mariana L. Oliveira. "Cell Signaling in Cancer." In Molecular and Cell Biology of Cancer, 31–49. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11812-9_3.
Повний текст джерелаMathonnet, M., A. Perraud, S. Blondy, N. Christou, H. Akil, S. Battu, and M. O. Jauberteau. "Cancer Stem Cell Niche." In Stem Cell Biology and Regenerative Medicine, 197–209. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21702-4_9.
Повний текст джерелаAdlung, Lorenz. "Cancer." In Cell and Molecular Biology for Non-Biologists, 103–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65357-9_9.
Повний текст джерелаТези доповідей конференцій з теми "111201 Cancer Cell Biology"
Gentles, Andrew J., Ajit J. Nirmal, Laura M. Heiser, Emma Lundberg, and Aaron M. Newman. "Single Cell Spatial Biology for Precision Cancer Medicine." In Pacific Symposium on Biocomputing 2023. WORLD SCIENTIFIC, 2022. http://dx.doi.org/10.1142/9789811270611_0052.
Повний текст джерелаTruong, Danh D., Emre Arslan, Margarita Divenko, Sandhya Krishnan, Alexander Lazar, Kunal Rai, and Joseph Ludwig. "Unraveling the Biology of Desmoplastic Small Round Cell Tumor." In Leading Edge of Cancer Research Symposium. The University of Texas at MD Anderson Cancer Center, 2022. http://dx.doi.org/10.52519/00091.
Повний текст джерелаKim, Carla F. "Abstract SY12-01: Stem cell approaches dissect lung cancer biology." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-sy12-01.
Повний текст джерелаCiccolella, Simone, Murray D. Patterson, Paola Bonizzoni, and Gianluca Della Vedova. "Effective Clustering for Single Cell Sequencing Cancer Data." In BCB '19: 10th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3307339.3342149.
Повний текст джерелаDing, XiaoFei, Ismael Sagredo, Gilbert Bustamante, Lu-Zhe Sun, Jing Yong Ye, and Frank DeLuna. "Label-free in vitro prostate cancer cell detection via photonic-crystal biosensor." In Biophysics, Biology and Biophotonics III: the Crossroads, edited by Adam Wax and Vadim Backman. SPIE, 2018. http://dx.doi.org/10.1117/12.2288019.
Повний текст джерелаLucarini, G., V. Iacovacci, L. Ricotti, N. Comisso, P. Dario, and A. Menciassi. "Magnetically driven microrobotic system for cancer cell manipulation." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7319179.
Повний текст джерелаKazmar, Tomáš, Matĕj Šmid, M. Fuchs, B. Luber, and J. Mattes. "Learning cellular texture features in microscopic cancer cell images for automated cell-detection." In 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010). IEEE, 2010. http://dx.doi.org/10.1109/iembs.2010.5626299.
Повний текст джерела"Recombinant lactaptin analogon RL2 inhibits TRAIL-induced cell death in breast cancer cell lines by mitophagy." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-608.
Повний текст джерелаRoberts, Penny, Peter Young, Doug Smith, Jeff Hooley, Jonathan Li, Francine Chen, Deryk Loo, Jennie Mather, and Paul A. Moore. "Abstract 5211: Development of a panel of colon cancer cell lines with cancer stem cell properties: a tool for cancer biology and target discovery." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-5211.
Повний текст джерелаWan, Yuan, Young-tae Kim, Li Na, Andrew D. Ellington, and Samir M. Iqbal. "Aptamer-Based Lab-on-Chip for Cancer Cell Isolation and Detection." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13195.
Повний текст джерелаЗвіти організацій з теми "111201 Cancer Cell Biology"
Park, M. S. Competency development in antibody production in cancer cell biology. Office of Scientific and Technical Information (OSTI), December 1998. http://dx.doi.org/10.2172/290996.
Повний текст джерелаDaley, George. Ovarian Cancer and Reproductive System Biology: A Harvard Stem Cell Institution Consortium. Fort Belvoir, VA: Defense Technical Information Center, December 2010. http://dx.doi.org/10.21236/ada542144.
Повний текст джерелаChen, Changmao, Yunfeng Chen, and Lian Chen. The Effects of TCM Combined with Chemotherapy in Patients with Non-small Cell Lung Cancer: An Overview of Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0114.
Повний текст джерелаKang, Jing, Jun Zhang, Zongsheng Tian, Ye Xu, Jiangbi Li, and Mingxina Li. The efficacy and safety of immune-checkpoint inhibitor plus chemotherapy versus chemotherapy for non-small cell lung cancer: an updated systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0156.
Повний текст джерелаJarron, Matthew, Amy R. Cameron, and James Gemmill. Dundee Discoveries Past and Present. University of Dundee, November 2020. http://dx.doi.org/10.20933/100001182.
Повний текст джерела