Готові списки джерел за темами / Μ-crystallins

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Добірка наукової літератури з теми "Μ-crystallins"

Автор: Grafiati

Опубліковано: 4 вересня 2022

Оновлено: 18 вересня 2022

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Статті в журналах з теми "Μ-crystallins"

Schröder, Imke, Alexander Vadas, Eric Johnson, Sierin Lim та Harold G. Monbouquette. "A Novel Archaeal Alanine Dehydrogenase Homologous to Ornithine Cyclodeaminase and μ-Crystallin". Journal of Bacteriology 186, № 22 (15 листопада 2004): 7680–89. http://dx.doi.org/10.1128/jb.186.22.7680-7689.2004.

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ABSTRACT A novel alanine dehydrogenase (AlaDH) showing no significant amino acid sequence homology with previously known bacterial AlaDHs was purified to homogeneity from the soluble fraction of the hyperthermophilic archaeon Archaeoglobus fulgidus. AlaDH catalyzed the reversible, NAD+-dependent deamination of l-alanine to pyruvate and NH4 +. NADP(H) did not serve as a coenzyme. The enzyme is a homodimer of 35 kDa per subunit. The K m values for l-alanine, NAD+, pyruvate, NADH, and NH4 + were estimated at 0.71, 0.60, 0.16, 0.02, and 17.3 mM, respectively. The A. fulgidus enzyme exhibited its highest activity at about 82°C (203 U/mg for reductive amination of pyruvate) yet still retained 30% of its maximum activity at 25°C. The thermostability of A. fulgidus AlaDH was increased by more than 10-fold by 1.5 M KCl to a half-life of 55 h at 90°C. At 25°C in the presence of this salt solution, the enzyme was ∼100% stable for more than 3 months. Closely related A. fulgidus AlaDH homologues were found in other archaea. On the basis of its amino acid sequence, A. fulgidus AlaDH is a member of the ornithine cyclodeaminase-μ-crystallin family of enzymes. Similar to the μ-crystallins, A. fulgidus AlaDH did not exhibit any ornithine cyclodeaminase activity. The recombinant human μ-crystallin was assayed for AlaDH activity, but no activity was detected. The novel A. fulgidus gene encoding AlaDH, AF1665, is designated ala.

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Serrano, Marta, Maria Moreno, Francisco José Ortega, Gemma Xifra, Wifredo Ricart, José María Moreno-Navarrete та José Manuel Fernández-Real. "Adipose Tissue μ-Crystallin Is a Thyroid Hormone-Binding Protein Associated With Systemic Insulin Sensitivity". Journal of Clinical Endocrinology & Metabolism 99, № 11 (1 листопада 2014): E2259—E2268. http://dx.doi.org/10.1210/jc.2014-1327.

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Background: Circulating thyroid hormones have been described to be intrinsically associated with insulin sensitivity in healthy subjects. μ-Crystallin is a nicotinamide adenine dinucleotide phosphate-dependent thyroid hormone-binding protein that has been shown to bind T3 in the cytoplasm. We aimed to study μ-Crystallin expression in adipose tissue and in muscle in association with insulin action and thyroid function. Methods: μ-Crystallin gene expression was studied in 81 visceral and 75 sc adipose tissue samples and in 26 muscle samples from a cohort of subjects with a wide spectrum of adiposity (cohort 1). μ-Crystallin was also evaluated in 30 morbidly obese subjects in whom insulin action was evaluated using euglycemic clamp (cohort 2) and in 22 sc adipose tissue samples obtained before and after bariatric surgery-induced weight loss (cohort 3). μ-Crystallin was also evaluated during differentiation of human adipocytes. μ-Crystallin was overexpressed in human sc adipocytes using lentiviruses. Results: μ-Crystallin gene expression was 2.6- to 3-fold higher in sc vs visceral adipose tissue in direct association with the expression of thyroid hormone receptor α 1 in cohort 1 and cohort 2. Visceral, but not sc, adipose tissue μ-Crystallin was positively associated with the serum T3/T4 ratio in cohort 1 and with insulin sensitivity in cohort 2. In fact, μ-Crystallin gene expression was significantly decreased in visceral adipose tissue (−43%) and in muscle (−26%) in subjects with impaired fasting glucose and type 2 diabetes. Weight loss did not result in significant sc adipose tissue μ-Crystallin changes. μ-Crystallin overexpression led to increased insulin-induced Ser473Akt phosphorylation in sc adipocytes. During differentiation of adipocytes, μ-Crystallin gene expression decreased in both visceral (P = .006) and sc (P = .003) adipocytes from obese subjects. Conclusion: Visceral, but not sc, adipose tissue μ-Crystallin is an adipose tissue factor linked to parameters of thyroid hormone action (T3/T4 ratio) and might mediate the interaction of thyroid function and insulin sensitivity.

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Di Matteo, Giovanni. "On admissible tensor products in p-adic Hodge theory." Compositio Mathematica 149, no. 3 (February 14, 2013): 417–29. http://dx.doi.org/10.1112/s0010437x1200070x.

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AbstractWe prove that if W and W′ are non-zero B-pairs whose tensor product is crystalline (or semi-stable or de Rham or Hodge–Tate), then there exists a character μ such that W(μ−1) and W′(μ) are crystalline (or semi-stable or de Rham or Hodge–Tate). We also prove that if W is a B-pair and if F is a Schur functor (for example Sym n or Λn) such that F(W) is crystalline (or semi-stable or de Rham or Hodge–Tate) and if the rank of W is sufficiently large, then there is a character μ such that W(μ−1) is crystalline (or semi-stable or de Rham or Hodge–Tate). In particular, these results apply to p-adic representations.

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Zhang, Xiu-Zhen, Yan-Wei Song, Fang HuiWu, and Qian-Feng Zhang. "Syntheses And Structural Characterizations Of Heterometallic Copper(I)/Indium(Iii) Complexes Containing Phosphine Ligands." Zeitschrift für Naturforschung B 62, no. 6 (June 1, 2007): 778–82. http://dx.doi.org/10.1515/znb-2007-0605.

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Addition of anhydrous InCl3 to a THF solution of CuCl and dppe (dppe = Ph2PCH2CH2PPh2), or CuCl and PPh3, resulted in the formation of the crystalline heterometallic copper(I)/indium(III) complexes [(dppeCu)2(μ-Cl)(μ-dppe)][InCl4]·THF (1·THF) and [{Cu(PPh3)2}2(μ-Cl)4(InCl)]·THF (2·THF), respectively, which have been characterized by X-ray diffraction. Compound 1 is composed of a dinuclear copper(I) complex cation and a mononuclear tetrahedral indium(III) complex anion. Complex 2 comprises an indium center in a quasi square-pyramidal chloride-coordination environment connected to two Cu(PPh)3 fragments via Cu(μ-Cl)2 In bridges

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Sharutin, V. V., A. P. Pakusina, I. V. Egorova, O. K. Sharutina та M. A. Pushilin. "New crystalline modification of μ-oxo-bis(bromotriphenylantimony)". Russian Journal of Coordination Chemistry 34, № 3 (березень 2008): 175–78. http://dx.doi.org/10.1134/s1070328408030044.

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Chowdhury, Habibar, and Chandan Adhikary. "Copper(II)-Nickel(II) Induced Cyanide Bridged 2D Heterometallic Coordination Polymer: Synthesis, X-ray Structure and Magnetic Study." Asian Journal of Chemistry 34, no. 6 (2022): 1472–76. http://dx.doi.org/10.14233/ajchem.2022.23678.

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One new two-dimensional heterometallic coordination polymer [Cu3Ni(L)2(CN)6]n (1) [L = 2-methylethylenediamine, CN– = cyanide ion] was synthesized and characterized by X-ray crystallography. Compound 1 crystallizes in the monoclinic C2/c space group. The single crystal X-ray structure of compound 1 indicated that it is a 2D coordination polymer with three copper(II) ion embedded with [Ni(CN)4]2- molecular ion in architecture through μ-CN/μ-NC bridges results heterometallic polymer. In compound 1, each Cu1 center with a CuN5 chromophore is encompassed by four N atoms of the two different bidentate amine (L) and one N atom of μ-NC ion, while both Cu2 and Cu3 centres are connected by three N atoms of μ-NC ions having CuN3 chromosphere and Ni1 are coordinated by three μ-CN and one terminal CN ions with NiC4 chromophore. Three copper centers and one nickel center are interlinked through μ-CN/μ-NC forming {-Cu1(L)2(μ-NC)Ni1(CN)(μ-CN)2Cu2(μ- NC)Cu3(μ-NC)-} unit to fabricate a 2D hetero metallic polymer. In the crystalline state of compound 1, each 2D polymer is further propagated through intermolecular N-H···N hydrogen bonds corroborant a supramolecular 2D network structure. Variable temperature magnetic susceptibility study displayed a weak antiferromagnetic spin coupling presumably due to the diamagnetic tetracyanonickellate bridging among the CuII ions.

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Sidletskiy, O., K. Lebbou, and D. Kofanov. "Micro-pulling-down growth of long YAG- and LuAG-based garnet fibres: advances and bottlenecks." CrystEngComm 23, no. 14 (2021): 2633–43. http://dx.doi.org/10.1039/d1ce00091h.

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A technological advance in shaped μ-PD crystal growth provided us with high-quality single crystalline fibres of rare-earth garnets with the good longitudinal transparency and light attenuation length of up to 1 m.

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Okuyama, Masahiko, Toshimi Fukui, and Chihiro Sakurai. "Effects of seeding on phase transformation and mechanical properties in complex-alkoxide-derived cordierite gel powder." Journal of Materials Research 7, no. 8 (August 1992): 2281–87. http://dx.doi.org/10.1557/jmr.1992.2281.

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Cordierite gel powder prepared by the hydrolysis of an alkoxide complex was seeded with crystalline α-cordierite particles. The effects of seeding on the phase transformation and mechanical properties were studied. The unseeded cordierite gel powder crystallized into α-cordierite via μ-cordierite at 1050 °C. The μ-α cordierite transformation caused microcracks which led to poor flexural strengths of about 30 MPa, although the strength of μ-cordierite was 160 MPa. The seeding appeared to promote a direct formation of the α-cordierite from the amorphous state. The development of microcracks due to μ-α cordierite transformation could be prevented by the modified crystallization behavior, resulting in the improved flexural strength of α-cordierite of 190 MPa. The seeding also lowered the crystallization temperature of α-cordierite to 900 °C, which could be attributed to the epitaxial crystallization of the complex-alkoxide-derived cordierite gel powder.

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Sato, Takuma, Hiroaki Hanafusa, and Seiichiro Higashi. "Investigation on electrical characteristics of TFTs fabricated with germanium films crystallized by atmospheric-pressure micro thermal plasma jet irradiation." Japanese Journal of Applied Physics 61, SC (February 9, 2022): SC1011. http://dx.doi.org/10.35848/1347-4065/ac3d0b.

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Abstract Crystalline germanium (c-Ge) is an attractive material for a thin-film transistor (TFT) channel because of its high carrier mobility and applicability to a low-temperature process. We present the electrical characteristics of c-Ge crystallized by an atmospheric-pressure micro thermal plasma jet (μ-TPJ). The μ-TPJ-crystallized c-Ge showed a maximum Hall mobility of 1070 cm2 V−1 s−1 with a hole concentration of ∼1016 cm−3, enabling us to fabricate a TFT with a field-effect mobility (μ FE) of 196 cm2 V−1 s−1 and an ON/OFF ratio (R ON/OFF) of 1.4 × 104. R ON/OFF and μ FE were dependent on the scanning speed of the TPJ, implying different types of defects were induced in the channel regions. These findings show the possibility of TPJ irradiation as a promising method for making c-Ge TFTs on insulating substrates.

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Seko, Daiki, Shizuka Ogawa, Tao‐Sheng Li, Akihiro Taimura та Yusuke Ono. "μ‐Crystallin controls muscle function through thyroid hormone action". FASEB Journal 30, № 5 (30 грудня 2015): 1733–40. http://dx.doi.org/10.1096/fj.15-280933.

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Більше джерел

Дисертації з теми "Μ-crystallins"

Mirzaei, Saman. "An investigation of the expression of glucose regulated genes μ-crystallin and Molybdenum Cofactor Sulfurase C-Terminal in Diabetic Nephropathy". Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/an-investigation-of-the-expression-of-glucose-regulated-genes-crystallin-and-molybdenum-cofactor-sulfurase-cterminal-in-diabetic-nephropathy(59628b25-3573-449c-84f4-60d88fc6e6e7).html.

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Diabetic Nephropathy (DN), a major cause of end stage renal failure, is believed to result from hyperglycaemia-induced pathways in the kidney. We previously identified μ-crystalline (CRYM) and Molybdenum Cofactor Sulfurase C-terminal domain-containing protein 2 (MOSC2) as two of several hyperglycaemia-induced renal genes in the Goto-Kakizaki (GK) rat, and showed that both were regulated by glucose in vitro in human mesangial cells (HMCs). In the current thesis, we investigated their expression in models of diabetes as well as in circulating cells from DN patients, in order to evaluate these genes as potential biomarkers and to explore their possible roles in the pathophysiology of DN. The expression of CRYM and MOSC were examined in tissues obtained from in vivo mouse models including a streptozotocin (STZ)-induced model of diabetes reversible through islet transplantation, renal cells cultured in normal (5mM) and high (25mM) glucose, and blood samples from diabetic patients with and without nephropathy (n= 97)/ retinopathy (n= 36). mRNA levels were determined using qPCR relative to reference genes, and protein location/abundance was determined using immunofluorescence. Functional analysis included N-hydroxylation assays. Both CRYM and MOSC2 mRNAs increased during hyperglycaemia in the diabetic kidneys of the STZ-induced mice and this increase was attenuated by treatment of diabetes (P < 0.05). Immunohistochemistry revealed an abundant expression of both proteins in tubular cells, and very low expression in mesangial cells. The hyperglycaemia-induced increase in renal CRYM was specific as we could not demonstrate any change in cardiac CRYM, and similarly no change in expression was found under diabetic conditions in vitro in Molybdenum Cofactor Sulfurase Cterminal domain-containing protein 1 (MOSC1), a homolog of MOSC2. Surprisingly, in high glucose (HG), CRYM and MOSC2 mRNA levels showed a slight decrease in cultured tubular cells, whereas they showed a significant increase in HMCs. Biochemical analysis of MOSC protein showed that hyperglycaemia increased the Nreductive activity of MOSC2 protein. To evaluate CRYM and MOSC mRNA levels as potential biomarkers of DN, we examined their expression in the peripheral blood of diabetic patients. We could detect low levels of CRYM but there was no expression of MOSC2. However, the closely related homolog MOSC1 was expressed in the peripheral blood though its mRNA levels did not change in association with DN. CRYM mRNA levels were 7.4-fold increased in patients with type 2 nephropathy and this effect was strongest in patients with a well controlled nephropathy compared to those with proteinuria. However, we found that circulating CRYM mRNA was reduced in patients with retinopathy. Therefore it is currently unclear if circulating CRYM is associated with nephropathy and its low levels of expression suggest it may not be a useful biomarker. Our data suggest that diabetes leads to an increased expression of renal CRYM and MOSC2 mRNAs, and although there are high levels of both mRNAs in tubular cells, the up-regulation may be taking place in mesangial or other renal cells. Circulating CRYM mRNA levels showed changes in patients with nephropathy and retinopathy but MOSC1 remained unchanged. CRYM or MOSC1/2 are unlikely to be useful biomarkers for DN but may be involved in the pathways that lead to DN.

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Тези доповідей конференцій з теми "Μ-crystallins"

Ravindra, Deepak, Muralidhar K. Ghantasala, and John Patten. "The Annealing Effect of the High-Pressure Phases of Silicon During Micro-Laser Assisted Machining." In ASME/ISCIE 2012 International Symposium on Flexible Automation. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/isfa2012-7207.

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Micro-laser assisted machining (μ-LAM) is a novel micro/nano machining technique developed for ductile mode machining of ceramics and semiconductors. Ductile mode material removal is possible in a nominally brittle material due to the high-pressure phase transformation (HPPT) phenomenon during the machining process. The μ-LAM system utilizes an IR laser beam to preferentially heat and soften the workpiece material during the material removal process. The μ-LAM process has several direct benefits observed during the machining process: allows for deeper cuts in the ductile regime due to the enhanced ductility of the workpiece material, higher material removal rates as a result of deeper cuts, lower cutting forces due to the reduced workpiece hardness from the heating process, and less tool wear from the reduced hardness and lower cutting forces. The μ-LAM process also has an added benefit that eliminates any subsurface damage in the form of high-pressure phases (HPPs) that usually remain after the ductile mode material removal process. This paper discusses this added benefit that occurs due to an annealing effect that re-crystallizes the HPPs back to its original crystalline phase. Single point scratch tests are used to form the HPPs by performing ductile mode μ-LAM on single crystal silicon (Si). Micro-Raman (μ-Raman) spectroscopy is used to characterize the machined surface/subsurface and identify the HPPs and annealed phase.

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Ishihara, Ryoichi, Paul C. van der Wilt, Barry D. van Dijk, J. W. Metselaar та C. I. M. Beenakker. "Property of single-crystalline Si TFTs fabricated with μ-Czochralski (grain filter) process". У Electronic Imaging 2003, редактор Apostolos T. Voutsas. SPIE, 2003. http://dx.doi.org/10.1117/12.482582.

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