Добірка наукової літератури з теми "Α/γ Peptide"
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Статті в журналах з теми "Α/γ Peptide"
Amorín, M., V. Villaverde, L. Castedo та J. R. Granja. "New α,γ-peptide tubulets". Journal of Drug Delivery Science and Technology 15, № 1 (2005): 87–92. http://dx.doi.org/10.1016/s1773-2247(05)50011-x.
Повний текст джерелаBandyopadhyay, Anupam, та Hosahudya N. Gopi. "Hybrid Peptides: Direct Transformation of α/α, β-Unsaturated γ-Hybrid Peptides to α/γ-Hybrid Peptide 12-Helices". Organic Letters 14, № 11 (18 травня 2012): 2770–73. http://dx.doi.org/10.1021/ol300987d.
Повний текст джерелаRoussel-Jazédé, Virginie, Jesús Arenas, Jeroen D. Langereis, Jan Tommassen, and Peter van Ulsen. "Variable processing of the IgA protease autotransporter at the cell surface of Neisseria meningitidis." Microbiology 160, no. 11 (November 1, 2014): 2421–31. http://dx.doi.org/10.1099/mic.0.082511-0.
Повний текст джерелаLegrand, Baptiste, та Ludovic T. Maillard. "α,β‐Unsaturated γ‐Peptide Foldamers". ChemPlusChem 86, № 4 (квітень 2021): 629–45. http://dx.doi.org/10.1002/cplu.202100045.
Повний текст джерелаMisra, Rajkumar, Gijo George, Abhijith Saseendran, Srinivasarao Raghothama та Hosahudya N. Gopi. "Ambidextrous α,γ‐Hybrid Peptide Foldamers". Chemistry – An Asian Journal 14, № 23 (28 листопада 2019): 4408–14. http://dx.doi.org/10.1002/asia.201901411.
Повний текст джерелаAmorín, Manuel, Roberto J. Brea, Luis Castedo та Juan R. Granja. "The Smallest α,γ-Peptide Nanotubulet Segments: Cyclic α,γ-Tetrapeptide Dimers". Organic Letters 7, № 21 (жовтень 2005): 4681–84. http://dx.doi.org/10.1021/ol0518885.
Повний текст джерелаHirao, Takashi, Masahide Sato, Akira Shirahata, and Yoshiyuki Kamio. "Covalent Linkage of Polyamines to Peptidoglycan inAnaerovibrio lipolytica." Journal of Bacteriology 182, no. 4 (February 15, 2000): 1154–57. http://dx.doi.org/10.1128/jb.182.4.1154-1157.2000.
Повний текст джерелаMustafa, Ghulam, Hafiza Salaha Mahrosh, Mahwish Salman, Sumaira Sharif, Raheela Jabeen, Tanveer Majeed та Hafsah Tahir. "Identification of Peptides as Novel Inhibitors to Target IFN-γ, IL-3, and TNF-α in Systemic Lupus Erythematosus". BioMed Research International 2021 (13 листопада 2021): 1–11. http://dx.doi.org/10.1155/2021/1124055.
Повний текст джерелаDutta, Arpita, Suven Das, Purak Das, Suvendu Maity, Prasanta Ghosh та Soumya Shankha Biswas. "Unique supramolecular assembly of a synthetic achiral α, γ-hybrid tripeptide". Zeitschrift für Kristallographie - Crystalline Materials 237, № 1-3 (1 березня 2022): 77–81. http://dx.doi.org/10.1515/zkri-2022-0002.
Повний текст джерелаPassero, Christopher J., Marcelo D. Carattino, Ossama B. Kashlan, Mike M. Myerburg, Rebecca P. Hughey, and Thomas R. Kleyman. "Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel." American Journal of Physiology-Renal Physiology 299, no. 4 (October 2010): F854—F861. http://dx.doi.org/10.1152/ajprenal.00316.2010.
Повний текст джерелаДисертації з теми "Α/γ Peptide"
Amin, Mohamad N. "Synthesis of Amphiphilic α- and γ-AApeptides for Antimicrobial, Self-Assembly, and Mineralization Studies". Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4859.
Повний текст джерелаClaudel, Stéphanie. "Les peptides Vinylogues : des nouveaux outils pour la préparation d'analogues contraints de la substance P, de γ-aminoacides α, β-hydroxylés et de dihydroxylactames". Nancy 1, 2004. http://www.theses.fr/2004NAN10039.
Повний текст джерелаThis work concerns conception and synthesis of modified peptides and is divided in two parts. Firstly, it's the insertion of vinylogous amino acids with cis and trans conformation in neuropeptide of eleven amino acids which is substance P in order to understand its interaction with NK-1 receptor. A second study has been oriented on the preparation of g-amino peptides by hydrogenation of previous vinylogous amino acids. This structural modification has given a new SP's analog which has been tested. The second part is the methodology of synthesis using vinylogous peptides and is divided in three chapters. First one presents dihydroxylation's results of these residues with an asymmetric induction using chiral catalyst to obtain dihydroxylated g-amino acids. Second one is an application of these studies with a total synthesis of natural product extracted from nyctinastic plant. And the last one deals with preparation of dihydroxylated lactams leading to the synthesis of new azasugars
Messerschmitt, Alexandre. "Utilisation d’unités γ-lactames pour le développement de vecteurs de pénétration intracellulaire et la conception de foldamères". Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS018/document.
Повний текст джерелаThe use of α-amino-γ-lactam oligomers (Agl-αAA) as cell penetrating vectors are described in this work. These ribbon structured oligomers are able to cross the cell membrane to reach the cytosol and deliver a biologically active cargo. Unlike peptide sequences, these oligomers display a strong enzymatic resistance. A new family of α-amino-γ-lactam oligomers (Agl-βAA) obtained from conversion of /β peptide sequences are also described. Secondary structure of these molecules have been studied by NMR, FTIR, CD and XRD. These oligomers are able to adopt a stable 12-helix structure. Unexpectedly, these oligomers are soluble in aqueous mediums without any hydrophilic side chains
Wortmann, Maria [Verfasser]. "α- [Alpha] und γ-Peptide [Gamma-Peptide] aus synthetischen Cyclohexan- und Pyrrolidin-Aminosäuren / vorgelegt von Maria Wortmann". 2000. http://d-nb.info/959562605/34.
Повний текст джерелаVasudev, Prema G. "X-Ray Crystallographic Studies Of Designed Peptides : Characterization Of Novel Secondary Structures Of Peptides Containing Conformationally Constrained α-, β- And γ-Amino Acids And Polymorphic Peptide Helices". Thesis, 2009. http://hdl.handle.net/2005/922.
Повний текст джерелаGeranurimi, Azade. "Lactam-peptide modulators of biased interlukin-1 receptor signaling for mitigating inflammation without compromising immuno-vigilance." Thesis, 2019. http://hdl.handle.net/1866/23926.
Повний текст джерелаPreterm birth (PTB) is an unmet biomedical need. Despite efforts to counter the onset of preterm labor, the rate of premature birth has increased steadily in developed countries. The interleukin-1 receptor (IL-1R) has been pursued as a target for designing agents which can prolong labor and improve neonatal outcomes. Towards these goals, a lead peptide 101.10 had been shown to modulate the IL-1R, to delay PTB and to mitigate associated retinopathy of prematurity (ROP) by an allosteric mechanism featuring biased signaling. With the goals of understanding the active conformers and improving the activity of 101.10, methods were conceived for the synthesis and introduction of β-substituted α-amino γ-lactams into peptides. Applying such methods on 101.10 has provided insight into the structure-activity relationships required for allosteric modulation of the IL-1R. Peptidomimetics are promising structures that replicate peptide function and conformation. They offer the potential to improve molecular-recognition, to enhance transport across biological membranes, and to resist metabolism. Among peptidomimetic classes, α-amino γ-lactam (Agl) residues introduce covalent constraint to rigidify the peptide backbone and have been employed to favor turn secondary structures. β-Substituted Agl analogs offer additional potential to mimic and restrict peptide side-chain geometry. This thesis introduces effective methods for the stereo-controlled synthesis of β-substituted α-amino γ-lactams residues having various side chain functionality. Introduction of the parent Agl residue and β-substituted counterparts into biologically active peptides has been explored to study structure-activity relationships. Employing the IL-1R modulator 101.10 as a representative peptide, the described research has furnished novel labor delaying agents that can improve neonatal outcomes. In chapter 2, α-amino-γ-lactam (Agl) and β-hydroxy-α-amino-γ-lactam (Hgl) stereoisomers were employed to study the influence of configuration and hydroxyl group side chain on conformation and activity of the interleukin-1 receptor modulator peptide 101.10. The configuration and hydroxyl group side chain influenced the conformation and biological activity of Agl and Hgl-101.10 analogs. Circular dichroism (CD) spectroscopy illustrated β-turn conformers for specific analogs, such as [(3R,4S)-Hgl3]-101.10. The Agl and Hgl analogs were examined in a series of in vitro assays and in vivo models of PTB. Contingent on their structure vi and configuration, the lactam analogs exhibited different functional selectivity in the various biological pathways, and indicated the requirement for specific phenotypes. For example, inhibition of the JNK and ROCK kinase pathways were respectively shown to be important for delaying labor and diminishing vaso-obliteration in the PTB and ROP models. Notably, among the twelve analogs, [(3R,4S)-Hgl3]-101.10 was found to exhibit identical in vitro and in vivo activity as the parent peptide. In chapter 3, methods were developed for displacement of the β-hydroxy-α-amino-γ-lactam (Hgl) residue alcohol to introduce stereo-selectively different β-substituents on Agl residues. A combination of Mitsunobu chemistry on the trans Hgl residue, and nucleophilic ring opening of the cyclic sulfamidate derived from the cis lactam counterpart provided constrained mimics of Ser, Thr, Cys, Dap, Dab, His and Met residues. In chapter 4, various β-substituted lactams were introduced into the sequence of 101.10 by combination of solution and solid phases chemistry to further study the structural requirements for regulating the activity and signaling of this key cytokine mediator of inflammasome activation. Considering the activity of [(3R,4S)-Hgl3]-101.10, the β-substituted Agl analogs were synthesized possessing similar backbone and side chain configurations. Certain analogs exhibited promising biological activity in the ROP model meriting further study. In sum, methods were conceived for the synthesis and application of α-amino-γ-lactams and their β-substituted analogs to study peptide structure-activity relationships. Employing this chemistry on the IL-1R allosteric modulator 101.10 has identified the active conformer and in vitro activity responsible for ability to delay labor and mitigate retinopathy of prematurity. Considering the utility of the lactam synthesis methods for the development of improved agents for delaying labor and improving neonatal outcomes, this thesis has conceived useful prototypes for drugs to treat PTB, as well as useful methods for dissecting the structural requirements for peptide chemical biology.
Kosten, Marc [Verfasser]. "Beitrag zur Chemie der 2, 3, 4, 5-Tetrahydropyridine : Synthese von cyclischen β-Aminosäuren, β-Lactamen und β-Peptiden sowie schwefelhaltigen γ- und δ-Lactamen und α-Aminophosphonsäurederivaten / von Marc Kosten". 2003. http://d-nb.info/967061075/34.
Повний текст джерелаЧастини книг з теми "Α/γ Peptide"
Blaskovich, M. A., A. W. Wong, and G. A. Lajoie. "Synthesis of optically enriched β,γ-unsaturated α-amino acids." In Peptides 1994, 205–6. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_85.
Повний текст джерелаBlaskovich, M. A., and G. A. Lajoie. "Stereoselective synthesis of β-substituted-β-hydroxy α-amino acids and β,γ-unsaturated α-amino acids from serine and threonine." In Peptides, 167–69. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_52.
Повний текст джерелаTung, Roger D., Chong-Qing Sun, Don Deyo, and Daniel H. Rich. "Asymmetric syntheses of β-OH and β-OH, γ-alkyl α-amino acids: Analogs of the unusual cyclosporin amino acid MeBmt." In Peptides, 149–51. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_43.
Повний текст джерелаCai, Chaozhong, Wei Wang, Chiyi Xiong, Vadim A. Soloshonok, Minying Cai, and Victor J. Hruby. "Synthesis of β and γ-Substituted Prolines for Conformation-Activity Relationship Studies of the α-MSH Analogue MT-II." In Peptides: The Wave of the Future, 20–21. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_4.
Повний текст джерелаBecker, Richard C., and Frederick A. Spencer. "Fibrinolytic Agents." In Fibrinolytic and Antithrombotic Therapy. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195155648.003.0011.
Повний текст джерелаТези доповідей конференцій з теми "Α/γ Peptide"
Charon, M. H., L. Tranqui, A. Andrieux, G. Hudry-Clergeon, and G. Marguerie. "FIBRINOGEN BINDING TO ENDOTHELIAL CELLS AND INTERFERING PEPTIDES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644735.
Повний текст джерелаHenschen, A., та E. Müller. "ON THE FACTOR XIIIa-INDUCED CROSSLINKING OF HUMAN FIBRIN α-CHAINS". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644649.
Повний текст джерелаHantgan, R. R. "LOCALIZATION OF THE DOMAINS OF FIBRIN INVOLVED IN BINDING TO PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643773.
Повний текст джерелаBezeaud, A., та M. C. Guillin. "FUNCTIONAL CHARACTERIZATION OF HUMAN β-THROMBIN". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644665.
Повний текст джерелаKuyas, C., H. Sigrist, and P. W. Straub. "LOCALIZATION CF FIBRIN POLYMERIZATION SITES BY PHOTQAFFINITY LABELING." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643776.
Повний текст джерелаKaudewitz, H., A. Henschen, and R. E. Zimmermann. "ON THE IDENTITY OF PLATELET FIBRINOGEN WITH PLASMA FIBRINOGEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642934.
Повний текст джерелаMinno, G. Di, A. M. Cerbone, F. Cirillo, M. Colucci, N. Semararo, G. Di Santo, P. L. Mattioli, M. Mancini, and A. Quattrone. "ABNORMAL FIBRINOGEN (FIBRINOGEN NAPLES) CHARACTERIZED BY DETECTIVE INTERACTION WITH THROMBIN AND PLASMIN IN TWO YOUNG SIBLINGS WITH ARTERIAL THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644698.
Повний текст джерелаEdgecombe, M., M. C. Scrutton, and R. Kerry. "RELATIONSHIP BETWEEN ELEVATION OF CYCLIC-3∲,5∲-GMP (cGMP) AND AGGREGATE FORMATION IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644534.
Повний текст джерела