Добірка наукової літератури з теми "Zinc finger motifs"
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Статті в журналах з теми "Zinc finger motifs"
Zhang, XiaoHong, YuJi Miao, XiaoDan Hu, Rui Min, PeiDang Liu, and HaiQian Zhang. "Gamma Radiation-Induced Damage in the Zinc Finger of the Transcription Factor IIIA." Bioinorganic Chemistry and Applications 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/1642064.
Повний текст джерелаGREEN, Andrew, and Bibudhendra SARKAR. "Alteration of zif268 zinc-finger motifs gives rise to non-native zinc-co-ordination sites but preserves wild-type DNA recognition." Biochemical Journal 333, no. 1 (July 1, 1998): 85–90. http://dx.doi.org/10.1042/bj3330085.
Повний текст джерелаMAURER-STROH, SEBASTIAN, HE GAO, HAO HAN, LIES BAETEN, JOOST SCHYMKOWITZ, FREDERIC ROUSSEAU, LOUXIN ZHANG, and FRANK EISENHABER. "MOTIF DISCOVERY WITH DATA MINING IN 3D PROTEIN STRUCTURE DATABASES: DISCOVERY, VALIDATION AND PREDICTION OF THE U-SHAPE ZINC BINDING ("HUF-ZINC") MOTIF." Journal of Bioinformatics and Computational Biology 11, no. 01 (February 2013): 1340008. http://dx.doi.org/10.1142/s0219720013400088.
Повний текст джерелаGebelein, Brian, and Raul Urrutia. "Sequence-Specific Transcriptional Repression by KS1, a Multiple-Zinc-Finger–Krüppel-Associated Box Protein." Molecular and Cellular Biology 21, no. 3 (February 1, 2001): 928–39. http://dx.doi.org/10.1128/mcb.21.3.928-939.2001.
Повний текст джерелаHasegawa, Atsushi, Hiroshi Kaneko, Daishi Ishihara, Masahiro Nakamura, Akira Watanabe, Cecelia D. Trainor, Yamamoto Masayuki, and Ritsuko Shimizu. "GATA1 Changes DNA-Binding Fashion in a Binding-Site-Specific Manner and Alters Transcriptional Activity during Erythropoiesis." Blood 126, no. 23 (December 3, 2015): 3584. http://dx.doi.org/10.1182/blood.v126.23.3584.3584.
Повний текст джерелаParraga, G., L. Young, and R. E. Klevit. "Zinc-finger motifs and DNA binding." Trends in Biochemical Sciences 14, no. 10 (October 1989): 398. http://dx.doi.org/10.1016/0968-0004(89)90283-1.
Повний текст джерелаGao, Xiang, Daniel J. Rowley, Xiaowu Gai, and Daniel F. Voytas. "Ty5 gag Mutations Increase Retrotransposition and Suggest a Role for Hydrogen Bonding in the Function of the Nucleocapsid Zinc Finger." Journal of Virology 76, no. 7 (April 1, 2002): 3240–47. http://dx.doi.org/10.1128/jvi.76.7.3240-3247.2002.
Повний текст джерелаBowzard, J. Bradford, Robert P. Bennett, Neel K. Krishna, Sandra M. Ernst, Alan Rein, and John W. Wills. "Importance of Basic Residues in the Nucleocapsid Sequence for Retrovirus Gag Assembly and Complementation Rescue." Journal of Virology 72, no. 11 (November 1, 1998): 9034–44. http://dx.doi.org/10.1128/jvi.72.11.9034-9044.1998.
Повний текст джерелаGuo, Jianhui, Tiyun Wu, Bradley F. Kane, Donald G. Johnson, Louis E. Henderson, Robert J. Gorelick, and Judith G. Levin. "Subtle Alterations of the Native Zinc Finger Structures Have Dramatic Effects on the Nucleic Acid Chaperone Activity of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein." Journal of Virology 76, no. 9 (May 1, 2002): 4370–78. http://dx.doi.org/10.1128/jvi.76.9.4370-4378.2002.
Повний текст джерелаGuo, Xuemin, John-William N. Carroll, Margaret R. MacDonald, Stephen P. Goff, and Guangxia Gao. "The Zinc Finger Antiviral Protein Directly Binds to Specific Viral mRNAs through the CCCH Zinc Finger Motifs." Journal of Virology 78, no. 23 (December 1, 2004): 12781–87. http://dx.doi.org/10.1128/jvi.78.23.12781-12787.2004.
Повний текст джерелаДисертації з теми "Zinc finger motifs"
Wang, Zhonghua Laity John H. "Characterization of novel structure-regulatory relationships within interacting two-finger Cys₂His₂ zinc finger protein motifs." Diss., UMK access, 2008.
Знайти повний текст джерела"A dissertation in cell biology and biophysics and molecular biology and biochemistry." Advisor: John H. Laity. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Sept.12, 2008. Includes bibliographical references (leaves 148-166). Online version of the print edition.
Guéguéniat, Julia. "Étude fonctionnelle des sous-domaines de Pcf11 : rôle du 2nd NTD dans la terminaison de transcription des snoRNAs et des motifs liant le zinc dans les activités de maturation de l’extrémité 3’ des ARN messagers." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0236/document.
Повний текст джерелаIn eukaryotes, poly (A) tails are added to nuclear pre-mRNA 3'-ends in the two steps of cleavage and polyadenylation. This co-transcriptional processing requires the activity of a large protein complex comprising at least 20 different polypeptides in yeast organized primarily into the two factors CF IA and CPF. We are interested in the functional characterization of Pcf11, a CF IA subunit. The Pcf11 protein is organized into seven different domains, but here is still a large portion of the polypeptide that has not yet been characterized. For example the region from the end of the CTD interaction domain (CID) to an uninterrupted stretch of 20 glutamine residues has no known function. Recently, the structure of this region, called the 2nd NTD have been characterized. To gain insight into the function of the 2nd NTD and the two zinc fingers motif surrounding the Clp1 interaction domain, we have employed a systematic strategy of mutagenesis, either by deletion or via point mutations. The 2nd NTD is a folded domain composed of three α-helices. The deletion of this domain induced a severe defect of growth in yeast and impaired transcription termination of snoRNAs. Despite its similarity in structure and function with the CID, the 2nd NTD seems to act like an independent RNA binding domain. We don’t know yet the real function of the two zinc fingers motif at the C-terminal region of Pcf11, but the mutation of Cystein residues into serine of one of the two motifs impaired cleavage and polyadenylation. The mutation of the first motif is less harmful than the mutation of the second motif. The simultaneous mutation is lethal in yeast
Oliveira, Alessandra Rejane Ericsson de. "Identificação e caracterização de uma proteína com motivos ZINC FINGER de Trypanosoma cruzi." reponame:Repositório Institucional da UnB, 2006. http://repositorio.unb.br/handle/10482/3320.
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Proteínas zinc finger são compostas por domínios compactados contendo α- hélices e folhas β unidos e estabilizados por um ou dois átomos de zinco. Arranjos repetidos de zinc fingers são comumente utilizados para reconhecimento de ácidos nucléicos. Dentre outras atividades, eles estão envolvidos em replicação, transcrição e reparo de DNA. No nucleocapsídeo do vírus HIV tipo 1 foi identificada uma proteína contendo o motivo zinc finger CX2CX4HX4C, estando esta proteína envolvida em várias etapas do ciclo de vida viral, incluindo a propriedade de encapsidação do RNA viral. Em tripanosomatídeos, somente poucas proteínas contendo o motivo zinc finger já foram identificadas até o presente momento. Em um fragmento genômico de 17 kb da banda XX de T. cruzi, nós identificamos três genes in tandem codificando para proteínas zinc finger do tipo CX2CX2HX4C. Nós também demonstramos que genes similares estão presentes em T. brucei e L. major como três definidos grupos monofiléticos entre esses tripanosomatídeos. Em T. cruzi, TcZFP8 corresponde a um novo gene codificando para uma proteína com oito motivos zinc finger. O homólogo de TcZFP8 em T. brucei é aparentemente ausente, enquanto um candidato foi identificado em L. major. A clonagem molecular e a expressão heteróloga de TcZFP8 foi realizada para produção de anticorpos e procedimentos como imunocitolocalização, SELEX e EMSA. Análise por Western blotting revelou a presença dessa proteína nas três formas do parasita. Análises usando extratos protéicos nucleares e citoplasmáticos de T.cruzi mostraram que essa proteína está presente na porção nuclear. Esse resultado foi confirmado através de análise de microscopia por imunofluorescência indireta. Experimento de SELEX demonstrou quatro diferentes populações com uma região interna rica em C e/ou G, porém sem seqüências consenso específicas. Análises preliminares de EMSA de uma das quatro populações selecionadas revelaram evidências de que TcZPP8 possa ter afinidade de ligação à fita simples de DNA. __________________________________________________________________________________________ ABSTRACT
Zinc fingers are compact protein domains composed of a α-helix and a β-sheet held together by a zinc ion. Tandem arrays of zinc fingers are commonly used to recognize nucleic acids. Among other activities, they are involved in the processes of replication, transcription, and DNA repair. The nucleocapsid protein of HIV-1 contains a zinc finger motif CX2CX4HX4C that contributes to multiple steps of the viral life cycle, including the proper encapsidation of HIV RNA. In trypanosomatids, only a few of the proteins that contain such fingers were identified. In a 17-kb genomic fragment of Trypanosoma cruzi chromosome XX we identified three tandemly linked genes coding for CX2CX4HX4C zinc finger proteins. We also showed that similar genes are present in Trypanosoma brucei and Leishmania major sharing three monophyletic groups among these trypanosomatids. In T. cruzi, TcZFP8 corresponds to a novel gene coding for a protein containing eight zinc finger motifs. Homologous of TcZFP8 in T. brucei is apparently absent, while one candidate in L. major was identified. Molecular cloning of gene TcZFP8 and heterologous expression were performed in Escherichia coli. The purified recombinant protein His6x-TcZFP8 was used to produce antibody in rabbits and GST-TcZFP8 in SELEX and EMSA procedures. Using Western blot analysis, we observed the presence of this protein in all three forms of the parasite: amastigote, trypomastigote and epimastigote. Analysis using cytoplasm and nuclear cell extracts showed that this protein is present in the nuclear extracts and indirect immunofluorescence microscopy analysis confirmed the nuclear localization of the TcZFP8. SELEX experiment showed four different populations rich in C and/or G nucleotides, but with none consensus sequence. Preliminary EMSA from one population gave evidence that TcZFP8 has affinity to bind to singlestranded DNA.
Berardi, A. "STRUCTURAL INSIGHTS INTO THE INTERACTION BETWEEN THE TANDEM PHD FINGER DOMAIN P5C5 OF NSD1 AND THE ZINC FINGER MOTIF C2HR OF NIZP1." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/247139.
Повний текст джерелаJohn, Rosalind. "Identification of potential gene coding sequences within large cloned DNA arrays : analysis of zinc finger motif." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46844.
Повний текст джерелаPurcell, Jamie, and Jamie Purcell. "Investigating the RNA Binding Domains of MBNL1 and the Alternative Splicing Motifs They Recognize." Thesis, University of Oregon, 2012. http://hdl.handle.net/1794/12331.
Повний текст джерелаKondekar, Sumedha. "Untangling the Helicobacter pylori genome: Deciphering the significance of zinc finger motif(s) in Topoisomerase I catalysis." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/4879.
Повний текст джерелаRivlin, Anatoly A. "Study of mutations in the zinc finger motif of yeast ribosomal protein YL37a /." 1999. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9951832.
Повний текст джерела"Identificação e caracterização de uma proteína com motivos zinc finger de Trypanosoma cruzi." Tese, Biblioteca Digital de teses e Dissertações da UnB, 2006. http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=449.
Повний текст джерелаTripathi, Pankaj. "Selective Binding Of Meiosis-Specific Yeast Hop1 Protein, or Its ZnF Motif, To The Holliday Junction Distorts The DNA Structure : Implications For Junction Migration And Resolution." Thesis, 2008. https://etd.iisc.ac.in/handle/2005/894.
Повний текст джерелаЧастини книг з теми "Zinc finger motifs"
Hudson, Laurie G., Karen L. Cooper, Susan R. Atlas, Brenee S. King, and Ke Jian Liu. "Arsenic Interaction with Zinc Finger Motifs." In Arsenic, 289–314. Hoboken, NJ: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118876992.ch13.
Повний текст джерелаMély, Yves, Etienne Piémont, Monica Sorinas-Jimeno, Hugues de Rocquigny, Nathalie Jullian, Nelly Morellet, Bernard P. Roques, and Dominique Gerard. "Structure and tRNAPhe-Binding Properties of the Zinc Finger Motifs of HIV-1 Nucleocapsid Protein." In NATO ASI Series, 369–71. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-1349-4_31.
Повний текст джерелаde Rocquigny, H., Y. Mely, C. Z. Dong, D. Ficheux, D. Gérard, J. L. Darlix, M. C. Fournié-Zaluski, and B. P. Roques. "Interaction of the replication primer tRNA Lys with the HIV-1 nucleocapsid protein NCp7:Structural properties of zinc finger motifs monitored by fluorescence measurements." In Peptides, 777–79. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_258.
Повний текст джерелаRhodes, D., and A. Klug. "“Zinc Fingers”: A Novel Motif for Nucleic Acid Binding." In Nucleic Acids and Molecular Biology, 149–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83384-7_9.
Повний текст джерелаHu, Xiao-Yu, Xiang-Qun Li, and Rui Wang. "Studies on the synthesis and DNA-binding activity of zinc finger motif." In Peptides, 28–30. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-010-9069-8_6.
Повний текст джерелаKobs-Conrad, Susan F., Ann Marie DiGeorge, Hyosil Lee, and Pravin T. P. Kaumaya. "Folding and immunogenicity of a loop-structured peptide using the zinc-finger motif." In Peptides 1992, 561–62. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_252.
Повний текст джерелаSTRUHL, KEVIN. "HELIX-TURN-HELIX, ZINC-FINGER, AND LEUCINE-ZIPPER MOTIFS FOR EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS." In Proteins: Form and Function, 259–66. Elsevier, 1990. http://dx.doi.org/10.1016/b978-1-85166-512-9.50032-7.
Повний текст джерелаWinblad, Stefan, and Anne-Berit Ekström. "Myotonic Dystrophy." In Cognitive and Behavioral Abnormalities of Pediatric Diseases. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195342680.003.0057.
Повний текст джерелаТези доповідей конференцій з теми "Zinc finger motifs"
Lihu, Andrei, and Stefan Holban. "The influence of the background model on DNA motif prediction: An assessment for zinc finger transcription factor ZFX." In 2015 IEEE 10th Jubilee International Symposium on Applied Computational Intelligence and Informatics (SACI). IEEE, 2015. http://dx.doi.org/10.1109/saci.2015.7208216.
Повний текст джерелаЗвіти організацій з теми "Zinc finger motifs"
Gmeiner, William H. Metal Occupancy of Zinc Finger Motifs as Determinants for Zn2+-Mediated Chemosensitization of Prostate Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, December 2013. http://dx.doi.org/10.21236/ada596731.
Повний текст джерела