Дисертації з теми "Zebrafish model system"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-19 дисертацій для дослідження на тему "Zebrafish model system".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Kishida, Marcia Gruppi. "Investigating non-canonical vertebral development in the zebrafish model system." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276830.
Повний текст джерелаBukrinsky, Alexander. "Zebrafish (Danio rerio) as a model system for human leukemia and hematopoiesis." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1666396561&sid=20&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаIyengar, Sharanya. "Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/796.
Повний текст джерелаIyengar, Sharanya. "Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/796.
Повний текст джерелаWu, Yuelong Ph D. Massachusetts Institute of Technology. "A high-throughput antiepileptic drug screening system based on chemically Induced zebrafish behavioral model." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/93816.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 53-59).
Epilepsy, which has the largest worldwide impacts among all nervous system diseases expect for stroke and dementia, is a group of long-term neurological disorders characterized by epileptic seizures. AED medications are the mainstay for epileptic seizure management. However, the existing AEDs cannot fit the needs for every patient due to the efficacy and side effect issues. In this thesis, a high-throughput system to screen new antiepileptic drug is built up. Chemically induced zebrafish larvae are used as a seizure model. The change in fishes' behavior patterns serves as an indicator of the fishes' nervous system condition. The design of the behavior data acquisition setup as well as the requirements of its components is described. A fish tracking program that tracks the locomotion variables like the head position, the tail movement and sideway orientation etc. is developed. The tracking results are treated either by simply computing the statistics of the tracking variables or implementing behavior pattern classifications. Two test datasets involving two different convulsants and one known AED are acquired and analyzed. The results coincide with the existing knowledge about the chemicals' effects on the human nerve system, which suggests the system described in this thesis is promising to help with the actual AED development.
by Yuelong Wu.
S.M.
Lu, Po-Nien. "Zebrafish Epithalamus as a Model System for Studying Circadian Rhythms and Left-Right Asymmetry." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1333731416.
Повний текст джерелаPhelan, III Peter E. "Development of a Viral Disease Model and Analysis of the Innate Immune System in Zebrafish, Danio rerio." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/PhelanPE2004.pdf.
Повний текст джерелаLindquist, Tera M. "The development of zebrafish (Danio rerio) as a rapid and efficient model system for therapeutic drug screening for Spinal Muscular Atrophy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311694979.
Повний текст джерелаSchwerte, Thorsten. "Early development of the cardio-respiratory system in the model animals zebrafish (danio rerio) and xenopus laevis analysed with non-invasive computer assisted image analysis." Dortmund T. Schwerte, 2006. http://deposit.ddb.de/cgi-bin/dokserv?id=2789102&prov=M&dok_var=1&dok_ext=htm.
Повний текст джерелаEaton, Jennifer Lynn. "The Molecular Control of Zebrafish Isotocin Cell Development: A Potential Model for the Neurodevelopmental Causes of Autism and Prader-Willi Syndrome." [Kent, Ohio] : Kent State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1152190826.
Повний текст джерелаTitle from PDF t.p. (viewed Sept. 19, 2006). Advisor: Eric Glasgow. Keywords: oxytocin; isotocin; vasopressin; vasotocin; hypothalamo-neurohypophysial system; hypothalamus; development; autism; Prader-Willi Syndrome; single-minded; orthopedia; arylhydrocarbon nuclear translocator; Brn2; POU; zebrafish; behavior; paraventricular nucleus; supraoptic nucleus; preoptic nucleus; diencephalon; suprachiasmatic nucleus; thyroid transcription factor; sonic hedgehog; NK 2 transcription factor related; distal-less homeobox gene; homeobox; homeodomain; morpholino Includes bibliographical references (p. 230-266).
Ivarsson, Adam. "Expediting Gathering and Labeling of Data from Zebrafish Models of Tumor Progression and Metastasis Using Bespoke Software." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148691.
Повний текст джерелаWang, Mu-Yun. "Attention and individual behavioural variation in small-brained animals, using bumblebees and zebrafish as model systems." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8700.
Повний текст джерелаVillefranc, Jacques A. "Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/557.
Повний текст джерелаBläßle, Alexander [Verfasser], and Patrick [Akademischer Betreuer] Müller. "A systems biology approach to axis formation during early zebrafish embryogenesis : from biophysical measurements to model inference / Alexander Bläßle ; Betreuer: Patrick Müller." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1196701075/34.
Повний текст джерелаMathews, Bobby. "A zebrafish model system for drug screening in diabetes." Thesis, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17847.
Повний текст джерелаBoehmler, Wendy A. "Zebrafish as a model system to study dopamine-related neurological disorders." 2006. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-1455/index.html.
Повний текст джерелаCruz, Shelly Abad, and 柯雪莉. "Zebrafish an outstanding molecular model system to study novel physiological function of neuroendocrine related hormones." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/56186561207719048985.
Повний текст джерела國立臺灣大學
漁業科學研究所
99
Chapter I Cortisol controls epidermal ionocyte differentiation and proliferation by targeting Foxi3 transcription factors in zebrafish (Danio rerio) In teleost fish, skin/gill function, cell morphological changes and cell proliferation were greatly affected by cortisol during environmental acclimation. In the present study we examined the molecular mechanism behind cortisol action including its known receptor, glucocorticoid receptor (gr) in fish epidermal ionocyte progenitor development. Utilizing zebrafish for both in vivo and in vitro assay, together with the involvement of the neuroendocrine system in the skin development which includes the corticotrophin releasing factor (crf), crf receptor 1 (crfr1), crfr2 and melanocotropin 2 receptor (mc2r) or ACTH receptor. Cortisol treatment of zebrafish newly fertilized eggs suppressed gr transcripts without affecting mr. Transcripts of ionocyte marker genes for Na+-K+-ATPase rich cells (NaRCs): epithelial Ca+ channel (ecac) and H+-ATPase rich cells (HRCs): glial cell missing 2 (gcm2), Na+-H+-exchanger 3b (nhe3b) (B), H+-ATPase A-subunit (atp6v1a) were all upregulated upon cortisol treatment. Immunocytochemistry confirmed that both NaRCs and HRCs density were significantly increased. In addition, ionocyte progenitor specification and differentiation marker genes foxi3a and foxi3b spatial mRNA expression were increased after 24-48 h treatment of cortisol via in situ hybridization. Cell division was not affected but cell apoptosis was decrease at 48 hpf and increased at 72 hpf in the cortisol-treated group. Knock-down of gr by GR-ATG MO showed immense lowered NaRCs and HRCs numbers among GR morphants which is further confirmed by GR-SV MO. In contrast, loss of MR has no effect in epidermal stem cells and ionocyte density. In vitro, 24 h gill organ culture with cortisol treatment significantly increased NaRCs and HRCs numbers including upregulation of foxi3a/b transcripts. Hence, we propose that cortisol through gr targets foxi3a/b that regulates epidermal ionocyte progenitor specification/differentiation together with delayed apoptosis in which case caused proliferation of matured ionocytes as the apparent outcome. Chapter II Corticotropin releasing factor (CRF), CRF-receptors and related proteins contribution on skin development of zebrafish (Danio rerio) The systematic hypothalamus-pituitary-interrenal (HPI) axis was also demonstrated to play a critical role in the skin development. Loss of function assay by morpholino oligos showed crf and crfr1 significantly take part in the stem cell and ionocytes density. CRFR1 is the major receptor that could mediate CRF function. Both present maternally, these may suggest their importance during the early skin development in zebrafish. CRFR2 is also maternally deposited but it can be dispensable during skin development since there is no observed change in epidermal stem cells or ionocytes density and morphology upon crfr2 knock-down. Nevertheless, CRFR2 function cannot be ruled-out in other major physiological functions like in stress. Altogether, the present results serve as a foundation of the HPI axis as a systematic event or locally present in the zebrafish skin and gills. In which crf initializes this event through crfr1, as a separate and local function or as a complete course of signaling events together with that of cortisol-gr-foxi3a/3b axis major effect in the epidermal ionocyte progenitor differentiation. More future work has to be done to clarify more issues and provide better understanding in the neuroendocrinology of the skin.
Wee, Esther Ong Ee, and 王奕薇. "The Studies of Type I Interferon (zfIFNI) In Nervous Necrosis Virus Zebrafish Infected Model System." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/51959202511784236195.
Повний текст джерела國立臺灣海洋大學
水產養殖學系
99
Nervous necrosis virus (NNV) is an important fish pathogen belonging to the virus family Nodaviridae that targets nervous tissues primarily brain and retina. Piscine nodaviruses (betanodaviruses), the causative agents of viral nervous necrosis (VNN) or viral encephalopathy and retinopathy (VER) in a wide range of host fish species, has resulted in major economic losses for the marine aquaculture industry. Hence, efficient antiviral strategy has been developed nowadays. In previous study, interferon found to be played role in confronting viral infections as the first line of defense. In the present study, we investigated the inhibitory effect of type I (zfIFN) interferon during NNV infection in in vivo and in vitro. Recently type I IFN has been classified into two groups (group I and group II) based on their primary protein sequences and biological activity. In zebrafish, IFNØ1 belongs to group I, while IFNØ2 and IFNØ 3 belong to group II. Moreover,we interestingly found out group I and group II IFN showed different expression patterns even without NNV infection. To study functions of different IFN group, zfIFNI was cloned in pDsRed-IRES vector and expressed in NNV infection model system, zebrafish and GF1 cell line. We assumed that absence of group I IFN is critical in mortality rescue. So we treated GF1 cell line with pDsRedIFNK1 vector and the protection efficiency eventually lost after 24hpi. For in vivo studies, except overexpression of group I IFN, group II IFN also successfully showed a tendency towards protection against NNV infection and up-regulation of the expression of Mx protein by observing increasing of survival rate after NNV infection. We further found out group I IFN and group II IFN showed expression through TLR3/MDA5 /RIG-1 signalling pathway and induce JAK/STAT pathway for type I IFN production but IFNØ3 in group II IFN is not expressed through same pathway. To further get insights into fish interferon functions, we set up a model with group II morpholino-mediated knockdown techniques will help to illustrate the IFN functions. We concluded the involvement of group II IFN may play important role during development in larvae stage due to its phenotype changing and mortality rescue.
Mhanni, Aizeddin A. "Characterization of DNA methylation in the zebrafish, Danio rerio : implications for zebrafish use as a model system to study the role of DNA methylation in normal and abnormal development." 2003. http://hdl.handle.net/1993/19846.
Повний текст джерела