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Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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Статті в журналах з теми "Zebrafish model system"

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Belyaeva, N. F., V. N. Kashirtseva, N. V. Medvedeva, Yu Yu Khudoklinova, O. M. Ipatova, and A. I. Archakov. "Zebrafish as a model system for biomedical studies." Biomeditsinskaya Khimiya 56, no. 1 (January 2010): 120–31. http://dx.doi.org/10.18097/pbmc20105601120.

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Zebrafish (Danio rerio) are now firmly established as a powerful research model for many areas of biology and medicine. Here, we review some achievements of zebrafish - based assays for modeling human diseases and for drug discovery and development. For drug discovery, zebrafish are especially valuable in the earlier stages of research as they provide a model organism to demonstrate a new treatment's efficacy and toxicity before more costly mammalian models are used. This review provides examples of compounds known to be toxic to humans that have been demonstrated to functional similarly in zebrafish. Major advantages of zebrafish embryons are that they are readily permeable to small molecules added to their incubation medium and the transparent chorion enables the easy observation of development. Assay of acute toxicity (LC50 estimation) in embryos can also include the screening for developmental disorders as an indicator of teratogenic effects. We used zebrafish for toxicity testing of new drugs on the base of phospholipid nanoparticles. The organization of the genome and the pathways controlling signal transduction appear to be highly conserved between zebrafish and humans that allow using zebrafish for modeling of human diseases some examples of which are illustrated in this paper.
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Wasel, Ola, and Jennifer L. Freeman. "Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration." International Journal of Molecular Sciences 21, no. 17 (August 20, 2020): 5981. http://dx.doi.org/10.3390/ijms21175981.

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The zebrafish (Danio rerio) is routinely used in biological studies as a vertebrate model system that provides unique strengths allowing applications in studies of neurodevelopmental and neurodegenerative diseases. One specific advantage is that the neurotransmitter systems are highly conserved throughout vertebrate evolution, including between zebrafish and humans. Disruption of the dopaminergic signaling pathway is linked to multiple neurological disorders. One of the most common is Parkinson’s disease, a neurodegenerative disease associated with the loss of dopaminergic neurons, among other neuropathological characteristics. In this review, the development of the zebrafish’s dopaminergic system, focusing on genetic control of the dopaminergic system, is detailed. Second, neurotoxicant models used to study dopaminergic neuronal loss, including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the pesticides paraquat and rotenone, and 6-hydroxydopamine (6-OHDA), are described. Next, zebrafish genetic knockdown models of dj1, pink1, and prkn established for investigating mechanisms of Parkinson’s disease are discussed. Chemical modulators of the dopaminergic system are also highlighted to showcase the applicability of the zebrafish to identify mechanisms and treatments for neurodegenerative diseases such as Parkinson’s disease associated with the dopaminergic system.
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Yoder, Jeffrey A., Michael E. Nielsen, Chris T. Amemiya, and Gary W. Litman. "Zebrafish as an immunological model system." Microbes and Infection 4, no. 14 (November 2002): 1469–78. http://dx.doi.org/10.1016/s1286-4579(02)00029-1.

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Amatruda, James F., Jennifer L. Shepard, Howard M. Stern, and Leonard I. Zon. "Zebrafish as a cancer model system." Cancer Cell 1, no. 3 (April 2002): 229–31. http://dx.doi.org/10.1016/s1535-6108(02)00052-1.

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Goldsmith, J. R., and Christian Jobin. "Think Small: Zebrafish as a Model System of Human Pathology." Journal of Biomedicine and Biotechnology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/817341.

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Although human pathologies have mostly been modeled using higher mammal systems such as mice, the lower vertebrate zebrafish has gained tremendous attention as a model system. The advantages of zebrafish over classical vertebrate models are multifactorial and include high genetic and organ system homology to humans, high fecundity, external fertilization, ease of genetic manipulation, and transparency through early adulthood that enables powerful imaging modalities. This paper focuses on four areas of human pathology that were developed and/or advanced significantly in zebrafish in the last decade. These areas are (1) wound healing/restitution, (2) gastrointestinal diseases, (3) microbe-host interactions, and (4) genetic diseases and drug screens. Important biological processes and pathologies explored include wound-healing responses, pancreatic cancer, inflammatory bowel diseases, nonalcoholic fatty liver disease, and mycobacterium infection. The utility of zebrafish in screening for novel genes important in various pathologies such as polycystic kidney disease is also discussed.
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Bilotta, Joseph, and Shannon Saszik. "The zebrafish as a model visual system." International Journal of Developmental Neuroscience 19, no. 7 (November 2001): 621–29. http://dx.doi.org/10.1016/s0736-5748(01)00050-8.

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Pitchai, Arjun, Rajesh Kannan Rajaretinam, and Jennifer L. Freeman. "Zebrafish as an Emerging Model for Bioassay-Guided Natural Product Drug Discovery for Neurological Disorders." Medicines 6, no. 2 (May 30, 2019): 61. http://dx.doi.org/10.3390/medicines6020061.

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Most neurodegenerative diseases are currently incurable, with large social and economic impacts. Recently, there has been renewed interest in investigating natural products in the modern drug discovery paradigm as novel, bioactive small molecules. Moreover, the discovery of potential therapies for neurological disorders is challenging and involves developing optimized animal models for drug screening. In contemporary biomedicine, the growing need to develop experimental models to obtain a detailed understanding of malady conditions and to portray pioneering treatments has resulted in the application of zebrafish to close the gap between in vitro and in vivo assays. Zebrafish in pharmacogenetics and neuropharmacology are rapidly becoming a widely used organism. Brain function, dysfunction, genetic, and pharmacological modulation considerations are enhanced by both larval and adult zebrafish. Bioassay-guided identification of natural products using zebrafish presents as an attractive strategy for generating new lead compounds. Here, we see evidence that the zebrafish’s central nervous system is suitable for modeling human neurological disease and we review and evaluate natural product research using zebrafish as a vertebrate model platform to systematically identify bioactive natural products. Finally, we review recently developed zebrafish models of neurological disorders that have the potential to be applied in this field of research.
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Maves, Lisa. "Special Issue “Zebrafish-A Model System for Developmental Biology Study”." Journal of Developmental Biology 8, no. 3 (August 4, 2020): 15. http://dx.doi.org/10.3390/jdb8030015.

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For this Special Issue “Zebrafish-A Model System for Developmental Biology Study,” we present a collection of studies, including original research papers and review articles, that focus on advances in developmental biology research and that take advantage of the zebrafish model organism [...]
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Nam, Youn Hee, Isabel Rodriguez, Sung Woo Shin, Ji Heon Shim, Na Woo Kim, Min Cheol Kim, Seo Yule Jeong, et al. "Characteristics of the New Insulin-Resistant Zebrafish Model." Pharmaceuticals 14, no. 7 (July 4, 2021): 642. http://dx.doi.org/10.3390/ph14070642.

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Insulin resistance, which occurs when insulin levels are sufficiently high over a prolonged period, causing the cells to fail to respond normally to the hormone. As a system for insulin resistance and diabetes drug development, insulin-resistant rodent models have been clearly established, but there is a limitation to high-throughput drug screening. Recently, zebrafish have been identified as an excellent system for drug discovery and identification of therapeutic targets, but studies on insulin resistance models have not been extensively performed. Therefore, we aimed to make a rapid insulin-resistant zebrafish model that complements the existing rodent models. To establish this model, zebrafish were treated with 10 μM insulin for 48 h. This model showed characteristics of insulin-resistant disease such as damaged pancreatic islets. Then we confirmed the recovery of the pancreatic islets after pioglitazone treatment. In addition, it was found that insulin-resistant drugs have as significant an effect in zebrafish as in humans, and these results proved the value of the zebrafish insulin resistance model for drug selection. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that insulin resistance altered gene expression due to the MAPK signaling and calcium signaling pathways. This model demonstrates the utility of the zebrafish model for drug testing and drug discovery in insulin resistance and diabetes.
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Elo, B., C. M. Villano, D. Govorko, and L. A. White. "Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase as a marker for exposure to anti-diabetic compounds." Journal of Molecular Endocrinology 38, no. 4 (April 2007): 433–40. http://dx.doi.org/10.1677/jme-06-0037.

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The zebrafish model system is one of the most widely used animal models for developmental research and it is now becoming an attractive model for drug discovery and toxicological screening. The completion of sequencing the zebrafish genome and the availability of full-length cDNAs and DNA microarrays for expression analysis, in addition to techniques for generating transgenic lines and targeted mutations, have made the zebrafish model even more attractive to researchers. Recent data indicate that the regulation of glucose metabolism in zebrafish, through the production of insulin, is similar to mammalian models, and many of the genes involved in regulating blood glucose levels have been identified in zebrafish. The data presented here show that adult zebrafish respond to anti-diabetic drugs similarly to mammalian models, by reducing blood glucose levels. Furthermore, we show that the expression of phosphoenolpyruvate carboxykinase (PEPCK), which catalyzes a rate-limiting step in gluconeogenesis and is transcriptionally regulated by glucagon and insulin, is regulated in larval zebrafish similarly to that seen in mammalian systems, and changes in PEPCK expression can be obtained through real-time PCR analysis of whole larval RNA. Taken together, these data suggest that larval zebrafish may be an appropriate model for the examination of glucose metabolism, using PEPCK as an indicator of blood glucose levels.
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Дисертації з теми "Zebrafish model system"

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Kishida, Marcia Gruppi. "Investigating non-canonical vertebral development in the zebrafish model system." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276830.

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A segmented vertebral column is one of the major innovations vertebrates. In mice and chicks – amniotes – a subpopulation of the somites, the sclerotome, is sole source of vertebral tissue. It is unclear, however, how applicable this amniote-based ‘canonical’ mechanism is across the vertebrates. In fact, the vast majority and diversity of vertebrates are not amniotes, but are members of ‘fish’ groups where there has been relatively little investigation into vertebral development. Indeed, there is great diversity in vertebra form throughout ‘fish’ groups and fossil evidence suggests that the components of the vertebra, the neural arches and the vertebral bodies, arose separately and that vertebrates have evolved multiple ways of building vertebral bodies. In teleosts fish, the vertebral bodies initially form as mineralised rings within the notochord sheath (chordacentra) and then secondarily, bone is deposited around this (perichordal centra and arches). Notochord cells (chordoblasts) have been implicated in chordacentrum mineralisation and patterning in zebrafish and Atlantic salmon, though the question of how the overtly unsegmented notochord could direct segmental mineralisation still remains. My project first aims to address this dual mechanism in the zebrafish model, by testing whether the chordoblasts can mineralise and pattern the chordacentra. The second aim is to elucidate the role of the sclerotome in teleost vertebral development. To do this, I explored CRISPR knock-in tools to label the sclerotome and used a Gal4 gene trap line to investigate sclerotome ablation. I characterised the chordacentra and chordoblasts in our model system and verified the specificity of a promoter as a chordoblast marker. With this promoter, I established a method to target the chordoblasts for KillerRed-induced phototoxicity. I demonstrated that intact chordoblasts are necessary for chordacentrum formation, but that vertebral arches are unaffected. Fused perichordal centra are still able to form, but the underlying sheath has a very different structure. This supports the ‘duality’ hypothesis that in teleosts the role of the sclerotome in vertebra formation is limited to the arches and perichordal centra, whereas the chordoblasts are responsible for the chordacentra.
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Bukrinsky, Alexander. "Zebrafish (Danio rerio) as a model system for human leukemia and hematopoiesis." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1666396561&sid=20&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Iyengar, Sharanya. "Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/796.

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During regeneration, cells must coordinate proliferation and differentiation to rebuild tissues that are lost. Understanding how source cells execute the regeneration process has been a longstanding goal in regenerative biology with implications in wound healing and cell replacement therapies. Melanocytes are pigment-producing cells in the skin of vertebrates that can be lost during hair graying, injury and disease-related depigmentation. Melanoma is an aggressive skin cancer that develops from melanocytes, and it is hypothesized that melanoma cells have properties that are similar to melanocyte stem cells. To gain insight into melanocyte regeneration we set out to identify the source of regeneration melanocytes in adult zebrafish and the path through which progenitor cells reconstitute the pigment pattern. Using targeted cell ablation and single cell lineage-tracing analyses we identified that a majority of regeneration melanocytes arise through direct differentiation of mitfa-expressing progenitor cells. Concurrently, other mitfa-expressing cells divide symmetrically to generate additional mitfa-positive progenitors, thus maintaining regeneration capability. Using reporter assays and drug studies, we found that Wnt signaling gets turned on in progenitor cells during regeneration and Wnt inhibition after melanocyte ablation blocks regeneration. Based on our finding that Wnt signaling is active in differentiated melanocytes but not in the progenitor cells, we explored the role of Wnt signaling in tumor initiation. We found that approximately half of the melanomas are Wnt silent, and overexpression of dkk1b, a negative regulator of canonical Wnt signaling, accelerates melanoma onset. This work defines an unappreciated contribution by direct differentiation in melanocyte regeneration and suggests a broader role for this process in the maintenance of epithelial sheets. This study also identifies a shared pathway between melanocyte progenitors and melanoma cells, which could be applicable to other cancers.
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Iyengar, Sharanya. "Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/796.

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Анотація:
During regeneration, cells must coordinate proliferation and differentiation to rebuild tissues that are lost. Understanding how source cells execute the regeneration process has been a longstanding goal in regenerative biology with implications in wound healing and cell replacement therapies. Melanocytes are pigment-producing cells in the skin of vertebrates that can be lost during hair graying, injury and disease-related depigmentation. Melanoma is an aggressive skin cancer that develops from melanocytes, and it is hypothesized that melanoma cells have properties that are similar to melanocyte stem cells. To gain insight into melanocyte regeneration we set out to identify the source of regeneration melanocytes in adult zebrafish and the path through which progenitor cells reconstitute the pigment pattern. Using targeted cell ablation and single cell lineage-tracing analyses we identified that a majority of regeneration melanocytes arise through direct differentiation of mitfa-expressing progenitor cells. Concurrently, other mitfa-expressing cells divide symmetrically to generate additional mitfa-positive progenitors, thus maintaining regeneration capability. Using reporter assays and drug studies, we found that Wnt signaling gets turned on in progenitor cells during regeneration and Wnt inhibition after melanocyte ablation blocks regeneration. Based on our finding that Wnt signaling is active in differentiated melanocytes but not in the progenitor cells, we explored the role of Wnt signaling in tumor initiation. We found that approximately half of the melanomas are Wnt silent, and overexpression of dkk1b, a negative regulator of canonical Wnt signaling, accelerates melanoma onset. This work defines an unappreciated contribution by direct differentiation in melanocyte regeneration and suggests a broader role for this process in the maintenance of epithelial sheets. This study also identifies a shared pathway between melanocyte progenitors and melanoma cells, which could be applicable to other cancers.
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Wu, Yuelong Ph D. Massachusetts Institute of Technology. "A high-throughput antiepileptic drug screening system based on chemically Induced zebrafish behavioral model." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/93816.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 53-59).
Epilepsy, which has the largest worldwide impacts among all nervous system diseases expect for stroke and dementia, is a group of long-term neurological disorders characterized by epileptic seizures. AED medications are the mainstay for epileptic seizure management. However, the existing AEDs cannot fit the needs for every patient due to the efficacy and side effect issues. In this thesis, a high-throughput system to screen new antiepileptic drug is built up. Chemically induced zebrafish larvae are used as a seizure model. The change in fishes' behavior patterns serves as an indicator of the fishes' nervous system condition. The design of the behavior data acquisition setup as well as the requirements of its components is described. A fish tracking program that tracks the locomotion variables like the head position, the tail movement and sideway orientation etc. is developed. The tracking results are treated either by simply computing the statistics of the tracking variables or implementing behavior pattern classifications. Two test datasets involving two different convulsants and one known AED are acquired and analyzed. The results coincide with the existing knowledge about the chemicals' effects on the human nerve system, which suggests the system described in this thesis is promising to help with the actual AED development.
by Yuelong Wu.
S.M.
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Lu, Po-Nien. "Zebrafish Epithalamus as a Model System for Studying Circadian Rhythms and Left-Right Asymmetry." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1333731416.

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Phelan, III Peter E. "Development of a Viral Disease Model and Analysis of the Innate Immune System in Zebrafish, Danio rerio." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/PhelanPE2004.pdf.

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Lindquist, Tera M. "The development of zebrafish (Danio rerio) as a rapid and efficient model system for therapeutic drug screening for Spinal Muscular Atrophy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311694979.

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Schwerte, Thorsten. "Early development of the cardio-respiratory system in the model animals zebrafish (danio rerio) and xenopus laevis analysed with non-invasive computer assisted image analysis." Dortmund T. Schwerte, 2006. http://deposit.ddb.de/cgi-bin/dokserv?id=2789102&prov=M&dok_var=1&dok_ext=htm.

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Eaton, Jennifer Lynn. "The Molecular Control of Zebrafish Isotocin Cell Development: A Potential Model for the Neurodevelopmental Causes of Autism and Prader-Willi Syndrome." [Kent, Ohio] : Kent State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1152190826.

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Анотація:
Thesis (Ph.D.)--Kent State University, 2006.
Title from PDF t.p. (viewed Sept. 19, 2006). Advisor: Eric Glasgow. Keywords: oxytocin; isotocin; vasopressin; vasotocin; hypothalamo-neurohypophysial system; hypothalamus; development; autism; Prader-Willi Syndrome; single-minded; orthopedia; arylhydrocarbon nuclear translocator; Brn2; POU; zebrafish; behavior; paraventricular nucleus; supraoptic nucleus; preoptic nucleus; diencephalon; suprachiasmatic nucleus; thyroid transcription factor; sonic hedgehog; NK 2 transcription factor related; distal-less homeobox gene; homeobox; homeodomain; morpholino Includes bibliographical references (p. 230-266).
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Книги з теми "Zebrafish model system"

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Zebrafish protocols for neurobehavioral research. New York: Humana Press, 2012.

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2

Ton, Christopher. Zebrafish genomics and its applications: Vertebrate model system for understanding human cardiovascular development. 2002.

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Kalueff, Allan V., and Adam Michael Stewart. Zebrafish Protocols for Neurobehavioral Research. Humana Press, 2016.

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4

Pérez-Pomares, José M., and Robert Kelly, eds. The ESC Textbook of Cardiovascular Development. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.001.0001.

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A rapid inspection of the table of contents shows that we have grouped relevant cardiovascular developmental topics in five different sections, which move progressively from basic research to clinical relevance, concluding with a glance at the near future of this fast-moving field. All of these sections deal with concepts that are critical to understanding from where and how cardiac chambers (atria and ventricles), valves (atrioventricular and arterial), great vessels (aortic and pulmonary trunks), cardiac conduction system (nodes, bundles, and Purkinje fibres), and coronary blood vessels form. Throughout the book there is continuous reference to experimental animal models for developmental processes, including the mouse, chick, and zebrafish, often involving the application of state of the art technological innovations. This has allowed us to illustrate the more likely origins of specific forms of congenital heart disease, and to elaborate on the developmental substrate of certain forms of adult cardiovascular disease.
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Частини книг з теми "Zebrafish model system"

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Rahman, Farhana. "Zebrafish Model and Cardiovascular System for Novel Therapies." In Zebrafish Model for Biomedical Research, 215–28. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5217-2_10.

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Wullimann, M. F., B. Rupp, and H. Reichert. "Introduction: neuroanatomy for a neurogenetic model system." In Neuroanatomy of the Zebrafish Brain, 1–5. Basel: Birkhäuser Basel, 1996. http://dx.doi.org/10.1007/978-3-0348-8979-7_1.

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Biran, Jakob, Janna Blechman, Einav Wircer, and Gil Levkowitz. "Development and Function of the Zebrafish Neuroendocrine System." In Model Animals in Neuroendocrinology, 101–31. Chichester, UK: John Wiley & Sons Ltd, 2018. http://dx.doi.org/10.1002/9781119391128.ch5.

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Maheshwari, Rajesh A., Dhanya B. Sen, Aarti S. Zanwar, and Ashim Kumar Sen. "Evaluation of Nanotoxicity Using Zebrafish: Preclinical Model." In Nanocarriers: Drug Delivery System, 173–97. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4497-6_7.

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Pamanji, Rajesh. "Zebrafish Model System in Antimicrobial Drug Discovery." In Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery, 597–609. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1695-5_30.

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Guo, Long, Shiro Ikegawa, and Chisa Shukunami. "Emergence of Zebrafish as a Model System for Understanding Human Scoliosis." In Zebrafish, Medaka, and Other Small Fishes, 217–34. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1879-5_11.

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Jagdale, Swati Changdeo, Asawaree Anand Hable, and Anuruddha Rajaram Chabukswar. "Zebrafish Model System to Investigate Biological Activities of Nanoparticles." In Model Organisms to Study Biological Activities and Toxicity of Nanoparticles, 177–94. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1702-0_9.

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Li, Qiaoli, and Jouni Uitto. "Zebrafish as a Model System to Study Heritable Skin Diseases." In Methods in Molecular Biology, 411–24. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-227-8_28.

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Schaaf, Marcel J. M., and Thomas S. Schmidt. "In Vivo Single-Molecule Microscopy Using the Zebrafish Model System." In Cell Signaling Reactions, 183–97. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9864-1_9.

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Baral, Reshica, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace. "Mass Spectrometry for Proteomics-Based Investigation Using the Zebrafish Vertebrate Model System." In Advances in Experimental Medicine and Biology, 331–40. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06068-2_15.

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Тези доповідей конференцій з теми "Zebrafish model system"

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Shirokov, Maxim, Valentin Milichko, and Vyacheslav Dyachuk. "Zebrafish as model system for cancer development." In INTERNATIONAL CONFERENCE ON PHYSICS AND CHEMISTRY OF COMBUSTION AND PROCESSES IN EXTREME ENVIRONMENTS (COMPHYSCHEM’20-21) and VI INTERNATIONAL SUMMER SCHOOL “MODERN QUANTUM CHEMISTRY METHODS IN APPLICATIONS”. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0031986.

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Mwaffo, Violet, Sachit Butail, and Maurizio Porfiri. "A Three Dimensional Model of Zebrafish Swimming." In ASME 2016 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/dscc2016-9773.

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Zebrafish is becoming an important animal model in pre-clinical studies for its genetic similarity to humans and ease of use in the laboratory. In recent years, animal experimentation has faced several ethical issues, calling for alternative methods that capitalize on dynamical systems theory. Here, we propose a computational modeling framework to simulate zebrafish swimming in three dimensions (3D) in the form of a coupled system of stochastic differential equations. The model is capable of reproducing the burst-and-coast swimming style of zebrafish, speed modulation, and avoidance of tank boundaries. Model parameters are calibrated on an experimental dataset of zebrafish swimming in 3D and validated by comparing established behavioral measures obtained from both synthetic and experimental data. We show that the model is capable of accurately predicting fish locomotion in terms of the swimming speed and number of entries in different sections of the tank. The proposed model lays the foundations for in-silico experiments of zebrafish neurobehavioral research.
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Zhao, Lilei, Liying Su, Nianqiang Cui, Zhuo Zhang, and Xuping Zhang. "A Nonlinear Mechanic Model of a Zebrafish Embryo under Microinjection." In CCRIS'21: 2021 2nd International Conference on Control, Robotics and Intelligent System. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3483845.3483895.

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4

Al-Ansari, Dana E., Nura A. Mohamed, Isra Marei, Huseyin Yalcin, and Haissam Abou-Saleh. "Assessment of Metal Organic Framework as Potential Drug Carriers in Cardiovascular Diseases." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0127.

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Background: Cardiovascular diseases (CVDs) are considered the major cause of death worldwide. Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of CVDs, including atherosclerosis, ischemic-reperfusion injury, and microvascular diseases. Despite their clinical benefits, current therapeutic drugs are hindered by their short half-life and systemic side effects. This limitation could be overcome using controlled drug release with the potential for targeted drug delivery using a nanomedicine approach. In the current study, we have assessed the use of a highly porous nano-sized preparation of iron-based Metal-organic Framework (MOF) commonly referred to as MIL-89 as potential drug carriers in the cardiovascular system. Aims: To assess the effect of MOFs on the viability and cytotoxicity of human vascular cells and the cellular uptake in vitro, and the organ-system toxicity of MOF in vivo using the Zebrafish model. Methods: Human pulmonary endothelial cells (HPAECs) and pulmonary smooth muscle cells (HPASMCs) were treated with variable concentrations of MOFs. The viability, cytotoxicity and anti-inflammatory effects were measured using AlamarBlue, LDH assay and ELISA. The cellular uptake of MOFs were assessed using light, confocal, and transmission electron microscopes and EDS analysis. Moreover, Zebrafish embryos were cultured and treated with MOFs-nanoparticles at 0 hours post fertilization (hpf) followed by different organ-specific assays at 24, 48, and 72 hpf. Results: Although MOFs affect the viability at high concentrations, it does not cause any significant cytotoxicity on HPAECs and HPASMCs. Interestingly, MOFs were shown to have an anti-inflammatory effect. Microscopic images showed an increased (concentration-dependent) cellular uptake of MOFs and transfer to daughter cells in both cell types. Moreover, the in vivo study showed that high concentrations of MOFs delay zebrafish embryos hatching and cause heart deformation, which is currently investigated using cardiotoxicity markers. Conclusion: MOFs is a promising nanoparticle prototypes for drug delivery in the cardiovascular system with high cellular uptake and anti-inflammatory effects. Further investigations of MOFs, including diseased models and drug- loaded formulation is required.
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Kwon, Hyuck-Jin, Yuhao Xu, Stephen A. Solovitz, Wei Xue, Alexander G. Dimitrov, Allison B. Coffin, and Jie Xu. "Design of a Microfluidic Device to Induce Noise Damage in Hair Cells of the Zebrafish Lateral Line." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-87135.

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Hearing loss affects millions of people worldwide and often results from death of the sensory hair cells in the inner ear. Noise-induced damage is one of the leading causes of hair cell loss. Recently, the zebrafish lateral line system has emerged as a powerful in vivo model for real-time studies of hair cell damage and protection. In this research, we designed a microfluidic device to induce noise damage in hair cells of the zebrafish lateral line. As the first step, a 3-D computational fluid dynamics (CFD) simulation was utilized to predict the flow pattern inside the device. An ideal flow pattern for our application should feature higher velocity at the side and lower velocity in the middle of a channel. Flow induced from ordinary channel geometry with single inlet/outlet pair would not work for us because the boundary layers from the two side walls will grow and merge with each other and induce the maximum flow speed in the middle of the channel. In order to achieve the desired flow pattern, side-wall inlet/outlet pairs were used to suppress the growth of boundary layers. CFD simulation was used to design important parameters such as dimensions of the microfluidic channel and the angle of inlets and outlets. It was found that flow velocity at the side of the channel could be 6.7 times faster than the velocity in the middle when we array the inlets and outlets alternatively and set the angle of the inlet to 45° with 2.0 mm main channel width. This 3-D CFD model will serve as a convenient model to design a microfluidic device to induce noise damage in hair cells of a zebrafish lateral line by manipulating the flow pattern inside the device.
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Salman, Huseyin Enes, Natalie Jurisch Yaksi, and Huseyin Cagatay Yalcin. "Computational Modeling of Motile Cilia Generated Cerebral Flow Dynamics in Zebrafish Embryo." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0128.

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Background: Motile cilia are hair-like microscopic structures, which move the fluids along the epithelial surfaces. Cilia cover a wide range of regions in the nervous system, such as the nasal cavity, spinal cord central canal, and brain ventricles. Motile cilia-driven cerebrospinal fluid (CSF) flow in the brain ventricles has an important role in the brain development. Embryos lacking motile cilia develop neurological defects due to altered CSF flow. Aim: To investigate the effect of motile-cilia motion on the altered CSF flow, and to understand the role of CSF flow in the brain development and physiology. Methods: The dynamics of motile-cilia driven flow is analyzed employing computational fluid dynamics (CFD) modeling. A 2D model is generated using the time-lapse microscopic movies showing movements of a fluorescently labeled motile-cilia in a zebrafish embryo (48-hour post-fertilization). The effects on the generated flow are elucidated by investigating the cilia beating angle, multiple cilia formations, and the phase difference between different ciliary beats. Results: Ciliary beating generated a directional flow in the form of a circulating vortex. The angle of ciliary beating significantly affected the flow velocity. As the angle between the wall and cilia decreases, the flow becomes more efficient by achieving higher velocities. Multiple cilia formations increased the flow velocity but the significance of multiple cilia is not as critical as the beating angle. Interestingly, phase difference between the multiple cilia beats increased the directional flow velocity. Conclusion: Motile-cilia generated flow dynamics are investigated, and it is concluded that out-of-phase multiple ciliary beating is the optimum form of beating in order to generate a directional flow.
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Butail, Sachit, Tiziana Bartolini, and Maurizio Porfiri. "Collective Response of Zebrafish to a Mobile Robotic Fish." In ASME 2013 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/dscc2013-3748.

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We investigate the response of groups of zebrafish, a model social organism, to a free-swimming robotic fish. The robot has a body and tail section and moves forward by beating the tail. Steering control is achieved by offsetting the beating tail with respect to the body. The color pattern and shape of the robot are informed by visual cues known to be preferred by zebrafish. A real-time multi-target tracking algorithm uses position and velocity estimates to autonomously maneuver the robot in circular trajectories. Observables of collective behavior are computed from the fish trajectory data to measure cohesiveness, polarization, and speed of the zebrafish group in two different experimental conditions. We show that while fish are significantly less polarized in the presence of the robot with an accompanying change in average speed, there is no significant change in the degree of cohesion.
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"Algorithm for Testing Behavioural Phenotypes in a Zebrafish Model of Parkinson’s Disease." In International Conference on Bio-inspired Systems and Signal Processing. SciTePress - Science and and Technology Publications, 2013. http://dx.doi.org/10.5220/0004238101960202.

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Futterman, Matthew, and Evan A. Zamir. "A Model for Epithelial Migration and Wound Healing in the Avian Embryo." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19565.

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It is increasingly clear that (collective) migration of epithelia plays an important role in morphogenesis and wound healing [6]. One of the interesting phenomena about epithelial migration is that the leading edge of the epithelia displays characteristics of both epithelia and cells undergoing EMT (epithelial-to-mesenchymal transition), so-called “partial” EMT. Developmental models in Drosophila and zebrafish have become important for studying signaling pathways involved in epithelial migration in recent years, but it is difficult to study the biomechanics of these systems. [2] Here, we revisit a little-used developmental model originally characterized by Chernoff [3] over two decades ago, which uses the area opaca (AO) of the chick embryo, an extraembryonic epithelium in birds which normally functions to spread across and encompass the nutritive yolk in a process called epiboly. We believe this model will be useful for studying epithelial migration because it is easily accessible and can be separated from the embryo to control the biomechanical environment.
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Liu, Yang, John Green, Carly R. Duffy, James D. Lauderdale, and Peter Kner. "Rapid 3D imaging of a seizure model in zebrafish using an electrically tunable lens with adaptive optics correction." In Adaptive Optics and Wavefront Control for Biological Systems VII, edited by Thomas G. Bifano, Sylvain Gigan, and Na Ji. SPIE, 2021. http://dx.doi.org/10.1117/12.2582541.

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Звіти організацій з теми "Zebrafish model system"

1

Gothilf, Yoav, Yonathan Zohar, Susan Wray, and Hanna Rosenfeld. Inducing sterility in farmed fish by disrupting the development of the GnRH System. United States Department of Agriculture, October 2007. http://dx.doi.org/10.32747/2007.7696512.bard.

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Hypothalamic gonadotropinreleasing hormone (GnRH1) is the key hormone in the control of gametogenesis and gonadal growth in vertebrates. Developmentally, hypothalamic GnRHproducing neurons originate from the olfactory placode, migrate along olfactory axons into the forebrain, and continue to the preoptic area and hypothalamus where they function to stimulate gonadotropin secretion from the pituitary gland. An appropriate location of GnRH neurons within the hypothalamus is necessary for normal reproductive function in the adult; abnormal migration and targeting of GnRH neurons during embryogenesis results in hypogonadism and infertility. The developmental migration of GnRH neurons and axonal pathfinding in mammals are modulated by a plethora of factors, including receptors, secreted molecules, adhesion molecules, etc. Yet the exact mechanism that controls these developmental events is still unknown. We investigated these developmental events and the underlying mechanisms using a transgenic zebrafish model, Tg(gnrh1: EGFP), in which GnRH1 neurons and axons are fluorescently labeled. The role of factors that potentially affect the development of this system was investigated by testing the effect of their knockdown and mutation on the development of the GnRH1 system. In addition, their localization in relation to GnRH1 was described during development. These studies are expected to generate the scientific foundation that will lead to developing innovative technologies, based on the disruption of the early establishment of the GnRH system, for inducing sterility in farmed fish, which is highly desirable for economical and environmental reasons.
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2

Ori, Naomi, and Sarah Hake. Similarities and differences in KNOX function. United States Department of Agriculture, March 2008. http://dx.doi.org/10.32747/2008.7696516.bard.

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Анотація:
Hypothalamic gonadotropinreleasing hormone (GnRH1) is the key hormone in the control of gametogenesis and gonadal growth in vertebrates. Developmentally, hypothalamic GnRHproducing neurons originate from the olfactory placode, migrate along olfactory axons into the forebrain, and continue to the preoptic area and hypothalamus where they function to stimulate gonadotropin secretion from the pituitary gland. An appropriate location of GnRH neurons within the hypothalamus is necessary for normal reproductive function in the adult; abnormal migration and targeting of GnRH neurons during embryogenesis results in hypogonadism and infertility. The developmental migration of GnRH neurons and axonal pathfinding in mammals are modulated by a plethora of factors, including receptors, secreted molecules, adhesion molecules, etc. Yet the exact mechanism that controls these developmental events is still unknown. We investigated these developmental events and the underlying mechanisms using a transgenic zebrafish model, Tg(gnrh1: EGFP), in which GnRH1 neurons and axons are fluorescently labeled. The role of factors that potentially affect the development of this system was investigated by testing the effect of their knockdown and mutation on the development of the GnRH1 system. In addition, their localization in relation to GnRH1 was described during development. These studies are expected to generate the scientific foundation that will lead to developing innovative technologies, based on the disruption of the early establishment of the GnRH system, for inducing sterility in farmed fish, which is highly desirable for economical and environmental reasons.
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