Готові списки джерел за темами / Young-onset colorectal cancer

Добірка наукової літератури з теми "Young-onset colorectal cancer"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Зміст

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Young-onset colorectal cancer".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "Young-onset colorectal cancer"

1

Done, Joy Zhou, and Sandy H. Fang. "Young-onset colorectal cancer: A review." World Journal of Gastrointestinal Oncology 13, no. 8 (August 15, 2021): 856–66. http://dx.doi.org/10.4251/wjgo.v13.i8.856.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Rosato, Valentina, Cristina Bosetti, Fabio Levi, Jerry Polesel, Antonella Zucchetto, Eva Negri, and Carlo La Vecchia. "Risk factors for young-onset colorectal cancer." Cancer Causes & Control 24, no. 2 (December 8, 2012): 335–41. http://dx.doi.org/10.1007/s10552-012-0119-3.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Lee, Lucas D., and Y. Nancy You. "Young-onset colorectal cancer: Diagnosis and management." Seminars in Colon and Rectal Surgery 29, no. 3 (September 2018): 98–101. http://dx.doi.org/10.1053/j.scrs.2018.06.002.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Mauri, Gianluca, Andrea Sartore‐Bianchi, Antonio‐Giampiero Russo, Silvia Marsoni, Alberto Bardelli, and Salvatore Siena. "Early‐onset colorectal cancer in young individuals." Molecular Oncology 13, no. 2 (December 22, 2018): 109–31. http://dx.doi.org/10.1002/1878-0261.12417.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Stoffel, Elena Martinez, Julie Ruterbusch, Laura S. Rozek, and Michele L. Cote. "Racial disparities in survival after young-onset colorectal cancer." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 524. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.524.

Повний текст джерела
Анотація:
524 Background: Despite overall reductions in morbidity and mortality from colorectal cancer (CRC), racial disparities persist. In addition, incidence among individuals age <50 is rising. Our aim was to compare survival of young onset CRC cases diagnosed in black and white individuals. Methods: Using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program we identified individuals with CRC between the ages of 20 to 49, diagnosed in 2000-2008. Kaplan-Meier and Cox proportional hazards models were used to compare stage-specific 5 year survival between black and white individuals with young onset CRC. Results: A total of 26,236 incident young onset CRC cases (22,121 white, 4,115 black) were identified during the 9 year study period. Overall survival at 5 years following CRC diagnosis was 54.8% among blacks and 67.4% among whites (p<0.001), with blacks having a significantly higher hazard of death after adjusting for age, sex, stage, tumor site, and treatment history (HR 1.34, 95% CI 1.26-1.43). Stratifying by stage at CRC diagnosis, blacks had worse survival at every disease stage compared with whites, with the greatest racial disparities observed among stage II cancers of colon (HR 1.68 95% CI 1.38-2.04) and stage II and III cancers of the rectum (HR 1.78, 95% CI 1.51-2.09, and HR 1.86, 95% CI 1.54-2.24, respectively). Conclusions: Survival after diagnosis of CRC at young age is significantly worse among blacks compared to whites, even among individuals with early stage disease. These findings suggest that differences in tumor biology may play a role in racial disparities in CRC outcomes, which may have implications for adjuvant treatment.
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Baraibar, Iosune, Francesc Salva, Raquel Comas, Javier Ros, Ariadna Garcia, Mireia Sanchis, Jose Luis Cuadra, et al. "Young-onset colorectal cancer: A call for action." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 10563. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10563.

Повний текст джерела
Анотація:
10563 Background: Young-onset colorectal cancer (YOCR) is defined as diagnosis below the age of 50. Over the past decades, the incidence of YOCRC has increased at an alarming rate, but causes and pathogenesis still remain unknown. Early detection of colorectal cancer (CRC) has demonstrated to improve survival. Despite these facts, adults < 50 years old are not yet included in screening programs and YOCRC is not well characterized. We aimed to characterize the clinical and molecular characteristics of YOCRC in patients (pts) diagnosed at our institution. Methods: Consecutive pts with a diagnosis of CRC below the age of 50 visited for the first time at Vall d’Hebron University Hospital in Spain between January 2017 and October 2020 were included in the analysis. Data of clinicopathologic features and treatment were collected retrospectively from medical records. Results: 205 pts met the inclusion criteria, 111 (54%) were females, 8 (4%) presented a personal history of cancer at diagnosis and 109 (53%) a family history of cancer. Age at diagnosis was: < 30: 10 (5%), {30 – 40): 52 (25%), {40-45): 51 (25%), {45-50): 92 (45%). Site of primary tumor was: right colon: 50 (24%), left colon: 107 (52%): rectum: 48 (24%). Stage at diagnosis was I: 3 (1%), II: 14 (7%), III: 60 (29%), IV: 128 (63%). 6 of 14 (43%) and 44 of 60 patients (73%) with stage II and III CRC presented disease progression after initial treatment, respectively. Molecular status was: KRAS mutation: 74 (36%), NRAS mutation: 7 (3%), BRAF mutation: 12 (6%), MSI-H: 12 (6%). 43 pts (21%) had documentation of genetic counseling. Median (range) number of lines of treatment for metastatic disease was 3 (1-7), 53 pts (30%) received at least 4 lines of treatment. Median (range) number of metastatic sites was: 2 (1-6). 114 patients (55.6%) had died at the cut-off timepoint. Conclusions: YOCR is usually diagnosed with a more advanced stage than standard-onset CRC, with a poorer course of the disease. Further studies in young adults with CRC should address this phenomenon to understand the underlying causes, and prioritize genetic counseling. Our results support the unmet need of initiating screening programs in adults younger than 50 years, the urgency for a global consensus and a call for action.
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Neufeld, D., B. Shpitz, N. Bugaev, M. Grankin, J. Bernheim, E. Klein, and Y. Ziv. "Young-age onset of colorectal cancer in Israel." Techniques in Coloproctology 13, no. 3 (July 16, 2009): 201–4. http://dx.doi.org/10.1007/s10151-009-0501-7.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Jayakrishnan, Thejus, Nicole Farha, Arshiya Mariam, Daniel Miller Rotroff, Federico Aucejo, Shimoli V. Barot, Madison Conces, et al. "Metabolomic differences in young-onset versus average-onset colorectal adenocarcinoma." Journal of Clinical Oncology 41, no. 4_suppl (February 1, 2023): 174. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.174.

Повний текст джерела
Анотація:
174 Background: Novel deleterious effects of environmental exposures may play a role in the rising incidence of young-onset colorectal cancer (yoCRC). We used metabolomics to assess differences between yoCRC and average-onset CRC (aoCRC), in comparison to healthy controls, which may suggest certain exposure risks. Methods: Patients with stage I-IV CRC and healthy controls were identified from prospective biobanks and categorized based on age<50 years (yoCRC or young controls) or age>60 years (aoCRC or older controls). Serum metabolites were profiled using GC-TOF mass spectrometry. Differential abundance of metabolites was investigated using unadjusted logistic regression. Metabolic pathway analysis was performed using Metaboanalyst 5.0. All p-values were adjusted for multiple testing (false-discovery rate, FDR p<0.20 considered significant). Results: The study population comprised 170 CRC patients (66 yoCRC and 104 aoCRC) and 49 healthy controls (34 young and 15 old). Association analyses revealed four differentially abundant metabolites: citrate (FDR p=0.04), cholesterol (0.14), and two unidentified metabolites (UM). Metabolic pathways significantly altered in yoCRC vs. aoCRC included: carbohydrate metabolism (citrate cycle, FDR p=0.11), carbohydrate biosynthesis (glyoxylate and dicarboxylate metabolism, FDR p=0.03), amino-acid metabolism (alanine, aspartate, and glutamate metabolism, FDR p=0.04, arginine biosynthesis, FDR p=0.04, and amino-acid t-RNA biosynthesis, FDR p=0.04). There were no significant metabolomic differences between young and older controls. Conclusions: We identified significant differences in the citrate cycle - a core pathway of cellular metabolism and associated with colorectal cancer. Metabolomic differences in pathways of carcinogenic significance (aspartate) and environmental exposures (arginine and dietary red meat) were also noted, suggesting potential relationships with younger age of CRC onset. The study provides future directions for more precise analyses with a larger sample size for healthy controls and adjusting for confounders. [Table: see text]
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Nwe, Khin Khin. "Colorectal cancer in young population: Yangon, Myanmar." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e14055-e14055. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14055.

Повний текст джерела
Анотація:
e14055 Background: CRC is the tenth most common cause of cancer in 2006 Myanmar Cancer Statistic. Recently, increased incidence of CRC among young age has been seen in our population. Methods: Demographic data of CRC pts registered in medical oncology unit, YGH from January 2009 to September, 2011 were studied. Age under 40 yrs was considered as a young patient. Stage distribution were analyzed to study about young onset CRC pattern. Results: Among 351 CRC patients registered, 120pts (34.19%) were under 40 yrs old. In young age group, age range from 12 to 40 yrs (median 29.5 yrs). Male to female ration was 1:1.26. Left-sided cancer (splenic flexure to rectum) in 93 patients (77.5%) and right sided (caecum to transverse colon) cancer in 27 pts (22.5%). Six pts (5%) were stage I, 41 people (34.17%) with stage II. Forty-four patients (36.67%) were node positive Stage III and 29 people (24.17%) with distant metastasis, Stage IV. Conclusions: Three percent of colorectal cancers occur in patients younger than 40 years of age in World Cancer Data. However, one third of CRC pts registered within 3 yrs in our unit were under age 40.The commonest stage seen in those pts were stage III at initial diagnosed. According to this data, younger onset of CRC in Myanmar is increasing although it doesn’t reflect the whole population. Further larger study is required to prove it. [Table: see text]
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Vadehra, Deepak, Beas Siromoni, Adrienne Groman, and Sarbajit Mukherjee. "Exploring demographic differences and outcomes in young-onset colorectal cancer." Journal of Clinical Oncology 41, no. 4_suppl (February 1, 2023): 35. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.35.

Повний текст джерела
Анотація:
35 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States (1). The incidence of young-onset CRC is on the rise based on recent data (2). Previous research on other cancers has shown that patients living in rural areas have worse outcomes (3). This study aimed to investigate the geographic and socio-demographic disparities in young-onset CRC patients. Methods: We conducted a retrospective study on colorectal cancer patients between 1975 and 2016 using the Surveillance, Epidemiology, and End Results (SEER) database. Both univariate and multivariable analyses were performed to evaluate overall survival (OS) and disease-specific survival (DSS). Socio-demographic factors, including the location of residence [metro area (MA) or rural area (RA)], gender, race, insurance status, and marital status, were analyzed. Young-onset colorectal cancer (CRC) was defined as the age of diagnosis less than 50 years. The program used for analysis was SAS software 9.4 (SAS Institute Inc., Cary, NC, USA.) Univariate and multivariable models were analyzed using Cox proportional models. Demographic differences between urban and rural population were assessed using Wilcoxon Rank Sum test (continuous variable) and Chi-square test (categorical variables). Results: A total of 73,378 [RA, N = 7,636(10.6%); MA, N = 64,605(89.4%)] young-onset CRC patients were included. RA had more Caucasian patients compared to MA (80.5% vs 60%, p < 0.001). Patients living in RA were more likely to be uninsured (4.8% vs 3%, p < 0.001) than MA. During the study period, the incidence and mortality rates were consistently higher in RA vs. MA. Univariate and multivariable analysis showed that RA had worse OS (multivariate HR = 1.14; p < 0.01) and DSS (multivariate HR = 1.15; p < 0.001) compared to MA. Similarly, males, single and uninsured patients had worse OS and DSS compared to females, married, and insured patients, respectively. Conclusions: Our study identified social and demographic disparities in young-onset CRC incidence and outcomes. Potential causes may include access to healthcare, diet, health behavior, and environmental factors. Future research is needed to understand and attenuate such disparities.
Стилі APA, Harvard, Vancouver, ISO та ін.
Більше джерел

Дисертації з теми "Young-onset colorectal cancer"

1

Mikaeel, Reger Romi. "Towards an Understanding of the Growing Incidence of Colorectal Cancer and Appendiceal Neoplasms in Young Adults." Thesis, 2022. https://hdl.handle.net/2440/135237.

Повний текст джерела
Анотація:
Colorectal cancer (CRC) incidence and mortality rates are rising in young adults aged <50 years old [referred to as young-onset CRC (YOCRC)] in Australia and many other countries while there has been a steady decline in overall rates of this malignancy in individuals aged ≥50 years old. In addition, the incidence and mortality rates of appendiceal neoplasms (ANs) have also been reported to be on the rise in both age groups (<50 years and ≥50) in the United States, Canada and Netherlands. Currently, the causes of these observations remain largely unknown. Identifying the underlying aetiological factors for YOCRC and ANs is a primary public health priority because addressing these contributing factors is a key prevention strategy. The main aim of this thesis is to explore the observation of the increasing incidence of CRC and ANs in young adults. The aetiology of YOCRC is likely to be heterogeneous, comprising a spectrum of genetic and environmental triggers. To this end, we have investigated the role of type 2 diabetes (T2D) as a marker of increased risk, and explored the exome in YOCRC patients for pathogenic germline variants. Consistent evidence suggests an association between T2D at any age and increased CRC risk. An observational study found that a personal history of T2D was significantly higher in YOCRC patients compared to controls (age- and sex-matched individuals with clear colonoscopies). In addition, analysis of exome sequencing data of YOCRC patients showed that one in six YOCRC patients had clinically actionable germline variants in at least one cancer-predisposing gene, with 35% of these being in genes associated with breast or ovarian cancer. First-degree relatives with CRC were rarely seen in variant carriers and three patients with variants in polyposis associated genes (MUTYH (bi-allelic), RNF43 and BMPR1A) showed no polyposis. In addition, two individuals with CRC were identified from a single-family carrying a likely-pathogenic germline variant in RNF43:c.375+1G>A. Tumours from both carriers were BRAFV600E-mutated and mismatch repair-proficient indicating that the CRCs arose in sessile serrated lesions. However, the proband did not meet the clinical criteria for serrated polyposis. Both studies taken together suggest that phenotype was a poor predictor of genotype. Trends in incidence and mortality rates of ANs in Australia were explored by performing a retrospective analysis on national data obtained from the Australian Institute of Health and Welfare from 1982 to 2013. Similar to the observed trend in other countries, this work has demonstrated that the incidence and mortality rates of ANs are alarmingly on the rise in Australia in both age groups (<50 years and ≥50), both genders, and within diverse histological subtypes. In conclusion, findings from this work suggest that there is an enrichment for personal history of T2D in patients with YOCRC, and that carriers of variants in breast/ovarian cancer-related genes might need to receive surveillance tests for CRC earlier than the general population, and importantly, that multigene panel testing is warranted for all YOCRC patients regardless of family history or phenotype. The findings also lend weight to further consideration for a hereditary role for RNF43 as a tumour suppressor gene in colorectal tumorigenesis outside the setting of individuals meeting the clinical criteria for serrated polyposis. In addition, an apparent rise in the incidence and mortality rates of ANs in Australia was demonstrated, the causes of which remain unclear. Further research exploring the risk factors for YOCRC and ANs is warranted, to stem the rising trend of both these malignancies.
Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2022
Стилі APA, Harvard, Vancouver, ISO та ін.

Тези доповідей конференцій з теми "Young-onset colorectal cancer"

1

Herk, M. E. van, M. Lee, M. Rytterdahl, M. E. Kop, A. F. Ramalheiro, R. van der Breggen, T. van Wezel, H. Morreau, E. S. Jordanova, and N. F. de Miranda. "Abstract 2942: Immunophenotypes in young-onset colorectal cancer." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2942.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Luo, Jingqin, Marios Giannakis, Graham Colditz, Jean Wang, William Chapman, Adetunji T. Toriola, Yoshiko Mito, et al. "Abstract 1228: Comparative genomic analysis of young-onset and late-onset colorectal cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1228.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Newcomer, Kimberley L., Ronit Yarden, and Never Too Young Advisory. "Abstract 3349: Collected experiences of young-onset colorectal cancer caregivers." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3349.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Newcomer, Kimberley L., Ronit Yarden, and Never Too Young Advisory. "Abstract 3349: Collected experiences of young-onset colorectal cancer caregivers." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3349.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Xing, Siyao, Suzanne Pomfret, Jonathan Landy, Drostan Cheetham, and Susan Catnach. "PWE-061 Young-onset colorectal cancer presentation in a DGH population compared to older-onset patients." In British Society of Gastroenterology Annual Meeting, 17–20 June 2019, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2019. http://dx.doi.org/10.1136/gutjnl-2019-bsgabstracts.385.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Murphy, Caitlin C., Piera M. Cirillo, Nickilou Y. Krigbaum, and Barbara A. Cohn. "Abstract 858:In uteroexposure to anti-nauseants and risk of young-onset colorectal cancer." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-858.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Peterson, Danielle, Tamara Springer, Kimberly Newcomer, and Ronit Yarden. "Abstract 2034: The young-onset colorectal cancer community speaks out about financial and emotional health." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2034.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Springer, Tamara, Kimberly Newcomer, Danielle Peterson, and Ronit Yarden. "Abstract 2352: Sexual morbidity and gender disparities among young-onset colorectal cancer patients and survivors." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2352.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Yarden, Ronit I., Kim L. Newcomer, and Never Too Young Advisory Board. "Abstract 3347: Young onset colorectal cancer patients are diagnosed with advanced disease after multiple misdiagnoses." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3347.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Yarden, Ronit I., Kim L. Newcomer, and Never Too Young Advisory Board. "Abstract 3347: Young onset colorectal cancer patients are diagnosed with advanced disease after multiple misdiagnoses." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3347.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
Також вас можуть зацікавити розширені добірки на тему "Young-onset colorectal cancer" для конкретних типів джерел:
Статті в журналах
Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!

До бібліографії