Дисертації з теми "Wound therapy"
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Coutin, Julia Viviana. "Cefazolin Concentration in Surgically Created Wounds Treated with Negative Pressure Wound Therapy Compared to Surgically Created Wounds Treated with Nonadherent Wound Dressings." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/49112.
Повний текст джерелаMaster of Science
Kairinos, Nicolas. "The biomechanics of negative-pressure wound therapy." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10809.
Повний текст джерелаDespite the success of negative-pressure wound therapy, its mechanism of action remains unclear. The common perception that it reduces tissue pressure and increases perfusion has recently been challenged following the observation that tissue necrosis can be caused as a result of its application. A programme of research has been conducted to clarify how tissue pressure changes during negative-pressure wound therapy and the resultant effect thereof on perfusion. The cause for conflicting evidence from other studies was also investigated.
Adams, Titus Sam Turner. "Topical negative pressure therapy in wound healing : a research tool to study neutrophil-mediated wound pathophysiology in acute dermal wounds." Thesis, University of Bristol, 2003. http://hdl.handle.net/1983/02226e50-d53c-40e4-a38a-cede0dc8161f.
Повний текст джерелаKesl, Shannon Lynn. "Metabolic Therapy for Age-Dependent Impaired Wound Healing." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6104.
Повний текст джерелаCho, Hongkwan. "Nanofiber-based therapy for diabetic wound healing: a mechanistic study." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352402217.
Повний текст джерелаHallen, Michael Ryan. "Commercialization of a Novel Wound Therapy and Scar Prevention Product." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1378942204.
Повний текст джерелаChildress, Beverly Bibera. "Nitric oxide metabolites in wound fluids from pressure ulcers on v.a.c.(tm) therapy." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0005140.
Повний текст джерелаTypescript. Title from title page of source document. Document formatted into pages; contains 84 pages. Includes Vita. Includes bibliographical references.
Simonson, Caitlin Judith. "Stem Cell Therapy in the Wound Healing Process in a Murine Model." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146217.
Повний текст джерелаByrnes, C. K. "Success and limitations of gene therapy with growth factors to enhance cutaneous wound healing." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273166.
Повний текст джерелаMendoza, Garcia Jenifer Guadalupe. "The role of photodynamic therapy in wound healing and scarring in human skin." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-photodynamic-therapy-in-wound-healing-and-scarring-in-human-skin(134fe004-9311-4f5d-a0c9-33efe9239960).html.
Повний текст джерелаTang, Wan-yi Winnie, and 鄧韻怡. "Evidence-based guideline for using negative pressure wound therapy in diabetic foot care." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46582940.
Повний текст джерелаXing, Kai-Lo Dorothy. "Investigations of bacterial uptake of chemical agents having relevance to burn wound therapy." Thesis, Robert Gordon University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258954.
Повний текст джерелаBukhari, Mamdouh. "In vitro-studies relating to honey as an alternative approach to wound therapy." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6669/.
Повний текст джерелаBauer, Joseph Alan. "Biochemistry of Nitric Oxide Donors: Therapy Vs. Toxicity." University of Akron / OhioLINK, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=akron1216144696.
Повний текст джерелаSmith, Annie G., Rachel A. Powis, D. I. Pritchard, and Stephen T. Britland. "Greenbottle (Lucilia Sericata) larval secretions delivered from a prototype hydrogel wound dressing accelerate the closure of model wounds." American Institute of Chemical Engineers (AIChE), 2008. http://hdl.handle.net/10454/4041.
Повний текст джерелаThe resurgence of larval biotherapy as a debridement tool in wound management has been accompanied by several clinical reports highlighting concomitant tissue regeneration. Studies employing in vitro cell motility assays have found that purified excretory/secretory (ES) products from Greenbottle larvae (blowfly, Lucilia sericata) are motogenic for human dermal fibroblasts when used as a supplement in culture media. The objective of the present study was to determine whether ES delivered using a prototype hydrogel wound dressing induced similar motogenic effects on fibroblastic (3T3) and epithelial cells (HaCaTs) comprising a scratched-monolayer wound model. Quantitative analysis by MTT assay failed to detect significant mitogenic effects of ES on either cell type. Quantitative image analysis revealed that ES exposure markedly accelerated wound closure through a motogenic effect on both fibroblasts and keratinocytes. Quantitative histochemical analysis detected significantly higher phosphotyrosine (pTyr) expression in ES-exposed cell cultures than in controls; moreover immunocytochemistry revealed conspicuously raised levels of pTyr expression in cells located at the wound margin. By attenuation with a panel of enzyme inhibitors these effects were attributed to the protease components of ES. The present results suggest that controlled delivery of ES as a follow-up to maggot debridement therapy may be an effective therapeutic option for stimulation of tissue regeneration in wound management.
Bagley, Angus H. "Proteomic and bioinformatic investigation of chronic wounds using non-invasive sampling to assess wound status and pathology." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/235131/1/Angus_Bagley_Thesis.pdf.
Повний текст джерелаModak, Ashin (Ashin Pramod). "Design and development of a smart, self-contained, portable negative pressure wound therapy device." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119769.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 137-143).
Negative pressure wound therapy (NPWT) is a commonly used treatment in which the application of a low vacuum (-20kPa) is used to accelerate the recovery of chronic, hard-to-heal wounds. Costs of chronic wounds such as diabetic foot ulcers are estimated to be $25 billion, with 6.5 million patients being affected. Improving the portability and efficacy of NPWT devices will allow a larger migration of patients from hospital stays to at-home care. Current portable NPWT devices have severe limitations due to their size, inability to dynamically modulate pressure or handle large volumes of wound exudate. The work in this thesis was to develop a more portable NPWT device in which all functional components are self-contained within the bandage itself. To accomplish this goal, a soft-material, fuel-cell based actuator was designed and incorporated into a self contained, compact pumping mechanism. Additionally graphene-oxide barriers were designed to allow for fluid management at the wound site. The designed bandage was able to maintain negative pressure even at worst-case scenario leak rates (6.7 x 102 mL/s) and an exudate rate of 5.6 x 10-5 mL/s. The contributions from this thesis are a novel, soft-materials based actuator for use in biomedical applications and the further characterization of graphene-oxide barriers.
by Ashin Modak.
Ph. D.
Yang, Weige. "sFlt-1 gene-transfected fibroblasts : A wound-specific gene therapy inhibits local cancer recurrence." Kyoto University, 2003. http://hdl.handle.net/2433/148677.
Повний текст джерелаStrauss, Graham L. "Hybrid Fusion Protein for Inhibition of Multiple Proteases for Chronic Wound Healing." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7957.
Повний текст джерелаAl-mzaiel, Anwar J. "Mechanisms by which hyperbaric oxygen therapy may resolve inflammation in chronic wounds." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1945.
Повний текст джерелаDaulton, Donna Lynn. "Using Optimal Control Theory to Optimize the Use of Oxygen Therapy in Chronic Wound Healing." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1232.
Повний текст джерелаLagan, Kathleen M. "Wound management in podiatry : use of Low Intensity Laser Therapy (LILT) and combined phototherapy/LILT." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287134.
Повний текст джерелаPreisz, Emilia, and Nathalie Berg. "Undertrycksbehandling av sår – påverkan på patientens livskvalitet och hälsa : En litteraturstudie." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-36049.
Повний текст джерелаSeghal, Nv-Preet Ashu. "The effect of low level laser therapy on selected cells involved in angiogenesis during wound healing." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287220.
Повний текст джерелаClements, B. Alyson. "Low intensity laser therapy (LILT) and combined phototherapy/LILT : effects upon blood flow and wound healing in humans." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241724.
Повний текст джерелаLengheden, Annelie. "Periodontal implications of calcium hydroxide treatment." Stockholm : Dept. of Oral Diagnosis, Karolinska Institutet, 1994. http://books.google.com/books?id=zfJpAAAAMAAJ.
Повний текст джерелаCarvalho, Camila Silva de. "Ação da polaridade na estimulação elétrica transcutânea para o tratamento de áreas doadoras de enxertos autógenos em pacientes queimados: estudo clínico randomizado cego." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17152/tde-06042018-101750/.
Повний текст джерелаThe cares with donor areas of skin grafts deserve constant attention, since it triggers discomfort due to pain and movement restriction. There are evidences that electric stimulation may accelerate wound healing and produce pain relief. The objective of this study was to evaluate the effect of electric current polarity on the healing and pain. Therefore, the effects of stimulation on high voltage pulsed current (HVPC) and nervous transcutaneous stimulation (TENS) were compared in the treatment of donor areas of burns victims. Therefore, 48 volunteers of the male sex were randomized between three groups: submitted to high voltage pulsed current stimulation (GHVPC), with 34.2 (± 9.8) years, n=17; submitted to nervous transcutaneous stimulation (GTENS), with 34 (±9.5) years, n=16; and nonsubmitted to stimulation group, or control group (GC), average age of 35 (± 9,5) years, n=15. The therapeutic procedures were applied on the edges of the donor area, at the first postoperative, until complete healing. The evaluated variables were ephitelization time (days), estimated by the unfastening of the primary curative on the wound, evaluation of pain by numerical scale of pain, skin temperature by infrared thermography, scar quality (photo book, Vancouver scale and Image J® software). After data analysis, the Shapiro-Wilk test was applied, and the Wilcoxon test was applied to the before and after intervention. Kruskal-Wallis test followed by Dunn post-hoc was used to compare the groups. In all cases, the significance level of 5% (p<0.05) was used. The findings indicate that the time of release of the Rayon dressing from the donor sites was significantly reduced for GEAV (p <0.033). A reduction of pain relief was significant (p<0.05) for the GEAV and for the GENT, when compared to the GC. Amount the number of solitation for analgesic drugs was decreased for the groups stimulated with significant difference of the GEAV verse GC (p<0.002) and GENT verse GC (p <0.001). Change in cutaneous temperature was not significant between groups. There was no difference significant in score of Vancouver scale and in the number of crusts in the groups. The polarity of the current might have influenced the healing time, however not the pain nor the quality of the donor site.
Morse, Zachary J. "Dose Response Analysis of Bone Marrow-Derived Mesenchymal Stem Cells for Treatment in Fascial Wound Repair." Youngstown State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1444052561.
Повний текст джерелаFors, Filip. "A Versatile Group of Molecules, Can Defensins Make an Impact in Medicine?" Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-157402.
Повний текст джерелаAbou, Issa Abdelfatah Shaban. "Effect of Oasis-Ultra Matrix on the Healing Rate of Stage IV Pressure Wounds." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464183028.
Повний текст джерелаNogueira, Flávio Marques. "Pressão exercida por sistema de pressão subatmosférica usado para fixação de enxerto de pele no tratamento de ferida cutânea. Estudo comparativo entre a tela de poliamida revestida de silicone e a tela de rayon como material de interposição." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-13112017-153849/.
Повний текст джерелаIntroduction: Wound care is a difficult and ever changing field. Among many therapies employed, autogenous skin grafting is often used. The quality of the skin graft and appropriate conditions of the recipient bed are paramount for the success of this surgical procedure. Moreover, the method of skin graft fixation and postoperative care are as important as the surgical technique itself. Hence, subatmospheric pressure wound therapy has been used in the process of fixation and integration of skin grafts in the treatment of wounds when there is frequently a layer between the sponge and the graft. Thus far there has been no standardization in the medical literature as to which layer to use. Objective: Compare two layers and measure how much each one alone interfered in the subatmospheric pressure generated by the pump used in subatmospheric pressure wound therapy, when set to generate a pressure gradient of 125 mmHg in relation to the atmospheric pressure of the surroundings. Methods: Two pilot studies were, therefore, undertaken of normal volunteers to ascertain the subatmospheric pressure under the rayon layer, under the polyamide layer and under the sponge. In one pilot study, of a total of 30 individuals, their measurements were taken in different moments and the setting was mounted and unmounted three times. In another, of 15 individuals, the measurements were collected within just one setting, as half of the sponge had rayon underlying it and the other half had polyamide beneath it. Therefore another prospective study was undertaken of 30 patients bearers of complex wounds in which both the rayon and the polyamide layer was used for each half of the skin grafted area The subatmospheric pressure measured under each layer and directly under the sponge (control measure) was assessed. Results: The results showed statistically significant differences between the pressure measured on the two layers studied and the pressure measured under the sponge. There was only one total skin graft loss. Conclusion: In conclusion, it was found that the different layers studied did reduce the subatmospheric pressure generated by the pump used in subatmospheric pressure wound therapy as compared with the respective control measure.
Virchenko, Olena. "Stimulation of tendon repair by platelet concentrate, CDMP-2 and mechanical loading in animal models." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1005s.pdf.
Повний текст джерелаMurphy, Kelly Elizabeth. "Mathematical investigation of the interactions between the inflammatory response and mechanical aspects of dermal wound repair." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/67907/1/Kelly_Murphy_Thesis.pdf.
Повний текст джерелаNussbaum, Ethne Louise. "An investigation into the effects of low intensity laser irradiation on bacterial growth : a possible factor in the effectiveness of laser therapy for wound healing." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394616.
Повний текст джерелаDanin, John. "Factors associated with healing of periradicular lesions." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-437-2/.
Повний текст джерелаGokavarapu, Venkatamanikanta Subrahmanyakartheek. "Computer Graphics and Visualization based Analysis and Record System for Hand Surgery and Therapy Practice." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464354599.
Повний текст джерелаNassu, Mariana Prado 1988. "Utilização de Cochliomyia macellaria F. (Diptera: Calliphoridae) e avaliação de sua densidade larval para uso terapêutico na recuperação de lesões tegumentares." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317754.
Повний текст джерелаTexto em português e inglês
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-25T17:11:16Z (GMT). No. of bitstreams: 1 Nassu_MarianaPrado_M.pdf: 4567544 bytes, checksum: 960ea243ca753828c2fce7d481fa59ff (MD5) Previous issue date: 2014
Resumo: A terapia larval (TL) consiste na aplicação de larvas estéreis de moscas necrófagas (Diptera) sobre lesões crônicas ou infectadas visando promover ou acelerar o processo de cicatrização. Para garantir segurança e sucesso, dois fatores tem de ser alcançados: a esterilidade das larvas que serão utilizadas e a confirmação de que a espécie, durante o seu processo de alimentação, consumirá apenas tecido necrosado. No presente estudo, pretendeu-se avaliar se a espécie Cochliomyia macellaria F. (Calliphoridae), de ampla distribuição em território brasileiro, pode ser uma excelente candidata para aplicação da TL, levando em conta seu comportamento e biologia. Foi avaliada a esterilização e a viabilidade pós-esterilização de larvas de C. macellaria em hipoclorito de sódio (NaClO) a 0,5% por um e por três minutos. Adicionalmente, lesões foram induzidas em ratos Wistar, para avaliar a qualidade e o tempo de cicatrização frente a diferentes tipos de tratamento. Para tanto, foram montados cinco grupos experimentais, sendo que em um deles os animais não foram submetidos a qualquer tipo de tratamento, e em outro foi feito desbridamento mecânico. Também foi avaliada qual a densidade larval (5, 15 ou 25 larvas/cm2) mais apropriada para obter melhor qualidade de cicatrização e, ao mesmo tempo, menor período de aplicação, visando adequar a TL a um atendimento do tipo ambulatorial, isto é, sem internação. O processo de cicatrização foi avaliado qualitativamente (a partir da mensuração de certos parâmetros associados às lesões) e quantitativamente (tempo). Fragmentos de pele foram coletados antes do tratamento e 12 h, 7 dias e 14 dias pós-tratamento, e processados para análise histológica. Em relação ao comportamento, foi observado que os imaturos de C. macellaria se alimentaram apenas de tecido necrosado. O uso de solução de NaClO a 0,5% por três minutos é o mais recomendado para obtenção de larvas estéreis com alta taxa de viabilidade. Não houve diferença significativa nos tempos de cicatrização entre os grupos experimentais. Contudo, foi observado que na relação de 25 larvas/cm2 houve um maior grau de vascularização nos tecidos, quando comparado aos demais tratamentos. Os mecanismos envolvidos nesse processo ainda são desconhecidos, mas concluiu-se que as larvas tem um importante papel na modulação da resposta imunológica do hospedeiro, sendo promissor o seu uso, provavelmente, em maiores densidades do que o preconizado na literatura
Abstract: Larval therapy (LT) is the application of sterile larvae of carrion flies (Diptera) on chronic or infected wounds to promote or accelerate the healing process. To ensure safety and success two aspects must be met: the sterility of the larvae and confirmation that the species consume only necrotic tissue during the feeding process. The present study intended to evaluate whether the species Cochliomyia macellaria F. (Calliphoridae), widely distributed in Brazil, could be a viable candidate for application of LT, taking into account their behavior and biology. Sterilization and post-sterilization viability of larvae of C. macellaria were evaluated after being treated with sodium hypochlorite (NaClO) at 0.5% during one and three minutes. Additionally, lesions were induced in Wistar rats to evaluate the healing quality and healing time against different types of treatment. For that, the rats were divided in five experimental groups, in one of them the animals were not subjected to any treatment and in another only mechanical debridement was performed. It was also evaluated which larval density (5, 15 or 25 maggots/cm2) is the most suitable for better quality of healing and at the same time, shorter period of application, in order to improve the LT to an outpatient care type, that is, without hospitalization. The healing process was assessed qualitatively (from the measurement of certain parameters associated with injuries) and quantitatively (time). Skin fragments were collected before treatment and 12 h, 7 days and 14 days post-treatment, and processed for histological analysis. Regarding the behavior, it was observed that immature C. macellaria fed only of necrotic tissue. The use of NaClO 0.5% solution for three minutes is the most recommended to obtain sterile larvae with high viability rate. There was no significant difference in healing times between the experimental groups. However, it was observed that in the group of 25 maggots/cm2 there was a higher degree of vascularization in tissues, as compared to other treatments. The mechanisms involved in this process are unknown, but it appears that the larvae have an important role in modulating the host immune response, and their use in higher density than that recommended in the literature is probably promising
Mestrado
Relações Antrópicas, Meio Ambiente e Parasitologia
Mestra em Biologia Animal
Williams, Tasha R. "FABRICATION AND CHARACTERIZATION OF ELECTROSPUN TECOPHILIC SCAFFOLDS FOR GENE DELIVERY." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1193882087.
Повний текст джерелаKamamoto, Fábio. "Estudo comparativo entre o método USP de terapia por pressão negativa e o sistema V.A.C® no tratamento de feridas traumáticas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-03052017-154110/.
Повний текст джерелаNegative Pressure Wound Therapy (NPWT) was approved by the FDA in 1996 and since then has become widely adopted for a broad range of wounds. NPWT has many indications, both acute and chronic, and has brought great comfort to patients, caregivers, doctors, and nurses. Some authors suggest that NPWT may be used in traumatic wounds when primary closure is not possible after or in between debridements as a bridge to definitive closure. The big real obstacle to this useful procedure is the cost, which remains expensive for prolonged indications, making it unaffordable where these dressings are needed. In 2007 the University of São Paulo developed a low-cost NPWT based in a pressure stabilizer device (Curavac VX 200®, Ventrix Health Innovation, Brazil) connected to the hospital wall-vacuum and a gauzed-sealed dressing. No randomised trial has compared USP Negative Pressure Wound Therapy with the commercial vacuum assisted closure device (VAC system®). Our choice of a non-inferiority trial was based on the expectation that the time necessary for the improvement of the wound bed for patients treated with the USP therapy was no worse than the improvement time for VAC System (primary outcome). The wound bed area variation and granulation tissue growth were also assessed as secondary outcomes. In relation to the time (measured in days) necessary for the wound bed to became ready for the flap surgery, the USP group presented 9,6 ± 4,5 days. The VAC group presented 12,8 ± 8,6 days. The difference was not statistical significant (p=0,379). In relation to granulation tissue increase the two methods of NPWT (USP and VAC) presented very similar results: USP= 5,79( ± 2,93) and VAC 5,06 ( ± 5,15) (p=0,408). Regarding to wound area the both groups presented an increase: USP 1,13 ± 0,80 and VAC 1,12( ± 0,80) p=0,934. We observed an important difference in relation to treatment costs. The USP group treatment cost is about 2% compared with VAC group. Mean Treatment Cost: USP= US$ 15,15; VAC= US$ 872,59. Conclusion: The USP Negative Pressure Wound Therapy was non-inferior to VAC System for the treatment of complex traumatic injuries
Bokums, Kristaps [Verfasser], and Johannes [Akademischer Betreuer] Hoffmann. "Irrigation suction drainage and negative pressure wound therapy of lower extremity vascular graft infection in ileofemoral region : clinical and economical aspects / Kristaps Bokums ; Betreuer: Johannes Hoffmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1163534188/34.
Повний текст джерелаBorglund, Marina, and Christine Helldén. "Larvterapi versus konventionella metoder i modern sårläkning av svårläkta sår. Effekter och upplevelse. //LARVA THERAPY VERSUS CONVENTIONAL METHODS IN MODERN WOUND HEALING OF ULCERS. EFFECTIVENESS AND EXPERIENCE." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25550.
Повний текст джерелаThe aim of this literature study is to compare larva therapy and conventional methods in treatment of ulcers on the basis of the following perspective: debridement of ulcers, duration of wound healing and patients´ experience. Polit & Becks (2006) model was used when working with this literature study. Search of relevant literature was done in three databases: PubMed, CINAHL and The Cochrane Library. Relevant articles were checked with the help of checklists modified of authors after Willman (2006). Nine different studies have been examined. The studies partly investigate the larva therapy’s effectiveness in debridement of ulcers and maggots´ capability in healing and partly how patients experience the larva therapy. This was set in relation to conventional treatment methods. The results are positive in larva therapy’s favour. Ulcers are debrided and healed quicker with few secondary effects compared to conventional treatments. Larva therapy is an effective way to debride necrotic and inflamed tissue in ulcers. Moreover new granulation tissue forms faster which is a condition for wound healing. Correct information and patients´ participation creates a positive attitude for this treatment. There is a big need for this in wound healing because of increased restrictions of use of antibiotics and desired decreased suffering for patients with ulcers. There are many possibilities with larva therapy if it continues to be researched.
Ciudad, Pedro, Maria I. Vargas, Ana Castillo-Soto, Jefferson R. Sanchez, Oscar J. Manrique, Samyd S. Bustos, Antonio J. Forte, Maria T. Huayllani, Zoila Soto, and J. Antonio Grández-Urbina. "Manejo de heridas traumáticas de difícil cicatrización con colgajos microvasculares." MA Healthcare Ltd, 2020. http://hdl.handle.net/10757/656659.
Повний текст джерелаObjective: Present different flap alternatives when performing microvascular free-flap reconstruction in acute hard-to-heal wounds. Method: A retrospective review of patients whose acute hard-to-heal wounds were treated with microvascular free-flap reconstruction. Data on demographics, wound aetiology, diagnostic, previous treatment, free-flap type, free-flap size, complications and follow up were analysed. Results: A total of 20 patients received microvascular free-flap reconstruction. The median age was 39.5 years. Twenty free-flap reconstructions were performed. These included: 3 cross-leg free flap, 1 cross-leg vascular cable bridge flap, 2 fibula osteocutaneous flap, 6 anterolateral thigh (ALT) flap, 3 thoracodorsal artery perforator (TDAP) flap, 3 fasciomyocutaneous flap, and 2 femoral artery fasciocutaneous flap. A patient required microvascular anastomosis due to hematoma; the rest did not present complications during their postoperative. Previous treatment included negative pressure wound therapy (12 patients) and surgical debridement with silver hydrogel dressings (8 patients). Conclusion: Hard-to-heal wounds can be unresponsive to traditional wound healing practices or local flaps. They often require free-flap reconstruction, using tissues similar to those compromised. Microvascular techniques can be an effective alternative. CONFLICT OF INTEREST None.
Borgo, Marcela. "Avaliação do processo de reparo de incisões realizadas em tecido cutâneo de ratos e submetidas a laser terapêutico." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/25/25147/tde-18082010-093650/.
Повний текст джерелаLow-power laser therapy has been used after surgical procedures to improve wound healing. However, although such kind of treatment offers little or no risk to the patient\'s health, its effectiveness remains controversial. This study was developed to evaluate the effect of low-power laser (100 mW) on the healing of skin incisions in rats. Two centimeters incisions were made on the back of fifty-six Wistar rats. After suturing, half of the animals received low-power laser application on three points, one on center and one on each end of the wound. For each point, a dose of 35 J/cm2 (InGaAIP laser, 660 nm, visible red) was administered. The other half of the animals served as control. The incised tissues were evaluated microscopically in a descriptive way in periods of 6 hours, 2, 7 and 14 days, considering the aspects of epithelium and connective tissue and the magnitude of inflammatory response, when present. For the first two periods, it was also done a morphometric evaluation, which measured the density of fibroblasts, collagen fibers, blood vessels and inflammatory cells in the connective tissue. In descriptive analysis, the greatest differences were found in the period of 6 hours, followed by the period of 2 days. In 6 hours, the laser-treated group showed less inflammatory response than control and, in some specimens, it was possible to see the beginning of epithelium proliferation on the edges of the wound. In two days, some specimens of the control group still showed remaining inflammatory cells, not observed in the laser group. In this period, it was also possible to see, in some specimens of the laser group, proliferation of fibroblasts along the edges of the wound. In the periods of 7 and 14 days, no differences were found between the groups. In morphometric analysis, density of collagen fibers and blood vessels was higher for the laser group in both evaluated periods, with statistically significant difference. Based on these results, it was concluded that low-power laser was able to control inflammatory response and stimulate tissue repair in skin wounds in rats.
Badenes, Marina Martins. "Avaliação da função de DII4 na neoangiogénese tumoral e fisiológica." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2009. http://hdl.handle.net/10400.5/2585.
Повний текст джерелаO ligando Delta-like 4 (Dll4), através da via de sinalização Notch, é um potente regulador da angiogénese, sendo expresso na componente arterial da vasculatura. Nos adultos, a sua expressão encontra-se aumentada numa grande variedade de condições patológicas. Neste estágio avaliou-se a regeneração de feridas em murganhos com perda-de-função condicional para Dll4 (Dll4-/-). A mutação Dll4-/- determina um aumento da densidade vascular, mas devido à fraca maturação dos vasos neoformados estes não são totalmente funcionais, têm fraca perfusão e elevada extravasação. Esta experiência inseriu-se num estudo mais alargado, que teve como objectivo determinar a quantidade ideal de inibição da expressão deste gene que resulte num aumento da vascularização sem diminuição de funcionalidade, de modo a tornar a terapia útil em situações que dependam da restauração da função vascular. A primeira área onde a terapia anti-Dll4 se revela promissora é na oncologia. Neste estágio efectuaram-se ensaios terapêuticos com proteína solúvel Dll4, proteína solúvel EphB4 e combinação de ambas, usando como modelo murganhos transgénicos que desenvolvem insulinomas autonomamente, nomeadamente murganhos nos quais, sob o controlo do promotor 1 do gene de insulina II de ratazana, o antigénio tumoral grande do vírus de símio 40 é expresso apenas nas células β das ilhotas de Langerhans do pâncreas (RIP1-Tag2). Os resultados indicaram que ambas as terapias conduzem a uma redução significativa do desenvolvimento tumoral, tendo o efeito mais pronunciado sido obtido mediante a administração combinada das proteínas Dll4 e EphB4.
ABSTRACT - Delta-like ligand 4 (Dll4), an arterial-specific component of the Notch pathway, is a potent regulator of angiogenesis. In adults, the expression of this gene is increased in a variety of pathological conditions. In this internship, we assessed wounds in inducible conditional knock-out mice, Dll4lox/loxFlp-/-Cre+/-. Deletion of Dll4 results in higher vascular density, but due to weak maturation the new vessels are poorly functional with low perfusion and high extravasation. This experiment is included in a larger trial aiming to determine the concentrations at which the Dll4-blocking therapy is capable of inducing an increase in vascularization without decreasing its functionality, making it useful in pathological condition that are dependant on vascular function. Oncology was the first area where anti-Dll4 therapy revealed a promising future. In this internship therapeutic assays were carried out with soluble Dll4 protein, soluble EphB4 protein and combination of both proteins in RIP1-Tag2 transgenic mice, which develop autochthonous insulinomas by the action of simian virus 40 large tumoral antigen (Tag2), which is expressed under the control of the rat insulin II gene promoter 1 (RIP1). Tumor development was largely reduced in all experimental groups with the best results obtained in the group treated with a combination of both proteins.
Ingrup, Lina, and Åse Lindgren. "Patientens upplevelse av undertrycksbehandling och dess påverkan på livskvalitet - en litteraturstudie." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25757.
Повний текст джерелаBackground: Negative Pressure Wound Therapy (NPWT) is a wound therapy, often used, when other therapies fail to heal the chronic wound. Several research studies support the effectiveness of the method regarding wound healing and granulation tissue formation, but the effect of treatment on the patient and his experience of using the treatment is lacking. Aim: The aim of the study was to describe the patient´s experience of undergoing negative pressure wound therapy and if the treatment affects the patient´s quality of life. Method: Literature review based on qualitative articles that responded to the main objective and quantitative articles that answered the research question. Results: The informants felt that the NPWT device was a focus in the treatment. The treatment was painful and affected the daily life and the informant´s self-image. The informants experienced a lack of information and support, and an inconsistency in the nursing staffs knowledge and skills. No significant difference in the quality of life were proved by comparing NPWT and standard wound treatment.Conclusion: NPWT treatment was perceived as a demanding wound treatment where the patient was challenged both physically and mentally. Treatment entailed a lot of own responsibility, was highly associated with pain and worry and anxiety overshadowed the goal of treatment.
Nóbrega, Fernando José de Oliveira. "Estudo histológico da ação do laser e da terapia fotodinâmica no processo de reparação de feridas cutâneas em ratos tratados com corticóide /." Araçatuba : [s.n.], 2005. http://hdl.handle.net/11449/96162.
Повний текст джерелаBanca: Nivaldo Antonio Parizotto
Banca: Álvaro Francisco Bosco
Resumo: O processo de reparo de feridas em indivíduos imunossuprimidos pelo uso de medicação corticóide representa um problema para a área da saúde. Diversos tipos de tratamento têm sido propostos para se obter uma melhor qualidade no processo de reparo, dentre esses destaca-se o uso do laser em baixa intensidade e, mais recentemente, a terapia fotodinâmica (PDT), representada pela associação do laser com drogas fotossensibilizadoras, como o Azul de Toluidina O (TBO). O propósito deste trabalho foi avaliar, histologicamente, a ação do laser em baixa intensidade e da PDT no processso de reparo em feridas cutâneas em ratos tratados com corticóide. Foram utilizados 90 ratos, nos quais foi criada, com o auxílio de um punch, uma ferida de 8 mm de diâmetro na porção média da região dorsal. Os animais foram divididos em 5 grupos: grupo 1 (n=18): os animais não receberam nenhum tipo de tratamento, tanto local quanto sistêmico; grupo 2 (n=18): os animais receberam corticóide sistêmico e nenhum tratamento local; grupo 3 (n=18): os animais receberam sistemicamente o mesmo tratamento do grupo 2, sendo as feridas tratadas com laser de baixa intensidade; grupo 4 (n=18): os animais receberam o mesmo tratamento sistêmico do grupo 2, sendo as feridas tratadas com irrigação de TBO; e grupo 5 (n=18): os animais receberam o mesmo tratamento do grupo 4, sendo as feridas tratadas imediatamente após a sua execução, com laser em baixa intensidade. Os animais, em número de 06 (seis) para cada grupo, foram sacrificados nos períodos de 3, 7 e 14 dias após a execução dos procedimentos terapêuticos. As peças foram processadas para análise histológica e coradas pela técnica da hematoxilina e eosina (H&E) e Tricômico de Masson. Os resultados mostraram que o grupo 2 promoveu um retardo na reparação tecidual em todos os períodos experimentais... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The process of wounds repair in immunosuppressed individuals for the use of corticoid therapy represents a problem for the area of health. Several treatment types have been proposed to obtain a better quality in the repair process. Among those, the use of low level laser may be emphasized and, more recently, the photodynamic therapy (PDT), represented by the association of that laser with photosensibilized drugs like toluidine blue O (TBO). The aim of this study was to evaluate, histologically, the action of the laser and of PDT in the repair process in cutaneous wounds in rats treated with corticoid. Ninety rats were used, in which was created, with the aid of a punch of 8 mm diameter, a wound in the medium portion of the dorsal region. The animals were divided in 5 groups: group 1 (n=18): the animals didn't receive any treatment type, local or systemic; group 2 (n=18): the animals received systemic corticoid and any local treatment; group 3 (n=18): the animals received systemically the same treatment of the group 2, being the wounds treated with low level laser; group 4 (n=18): the animals received the same systemic treatment of groups 2, being the wounds treated with irrigation of TBO; and group 5 (n=18): the animals received the same treatment of the group 4, being the wounds immediately treated after their execution with laser. The animals, in number of 06 (six) for each group, were sacrificed in the periods of 3, 7 and 14 days after the execution of the therapeutic procedures. The pieces were processed for histologic analysis and colored for the technique of hematoxylin-eosin (H&E) and Masson trichrome stains. The results showed that the group 2 promoted a retard in the tissue repair in all the experimental periods; the group 3 presented a more accelerated repair process than the group 4, as well as the group 5 was presented... (Complete abstract click electronic access below)
Mestre
Perea, Gil Isaac. "Cell-enriched engineered cardiac grafts improve heart function and promote cardiac regeneration: a novel therapy for myocardial infarction." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/454716.
Повний текст джерелаMyocardial infarction is one of the cardiovascular diseases with highest incidence and mortality worldwide. Despite the different treatments employed nowadays, none of them succeeded in reversing post-infarction sequelae or completely recovering cardiac function thus far. In this regard, cardiac tissue engineering is presented as a valid alternative to current therapies, combining the use of supportive matrices or scaffolds with therapeutic cells. However, the choice of both the scaffold and the cell lineage has not been fully elucidated yet. Thus, our working hypothesis proposes that the use of scaffolds derived from decellularized myocardium and pericardium, subsequently repopulated with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs), as a therapy for myocardial infarction, promotes cardiac regeneration and improves cardiac function. To carry out this hypothesis, we set out the following objectives: 1. Characterization of the immunomodulatory properties of the cardiac ATDPCs; 2. Generation of decellularized scaffolds from myocardial and pericardial tissue; 3. Recellularization of the acellular cardiac scaffolds with cardiac ATDPCs, generating myocardial (or EMG-ATDPC) and pericardial (or EPG-ATDPC) bioengineered constructs, respectively; and analysis of the cellular behavior of these cardiac ATDPCs seeded over the scaffolds; and 4. Evaluation of the effects exerted by the implantation of both EMG-ATDPC and EPG-ATDPC in a porcine model of acute myocardial infarction. According to the outcomes derived from the present study, the following conclusions were stated: 1. Cardiac ATDPCs do not induce activation of T-lymphocytes and, in addition, reduce their proliferative activity when these T-lymphocytes have been previously stimulated. Moreover, the cardiac ATDPCs also limit the secretion of proinflammatory cytokines released by the T-lymphocytes, indicating a low immunogenicity of our target cardiac ATDPCs. 2. The complete characterization of the myocardial and pericardial decellularized scaffolds shows a total absence of nuclei and cell debris, confirms the preservation of mechanical and structural properties of the matrix, and identifies the major matrix proteins typical of heart tissue, all together perfectly recreating the physiological cardiac microenvironment. 3. The decellularized cardiac scaffolds support recolonization with cardiac ATDPCs, retaining them alive and maintaining their vasculogenic potential. Cell density and migration, as well as preservation of cardiomyogenic potential by cardiac ATDPCs, are dependent on the type of cardiac scaffold used. And 4. The engraftment of EMG-ATDPC and EPG-ATDPC constructs promotes an enhancement in ventricular function, decreases infarct size, limits ventricular fibrosis progression, and induces neovascularization and neoinnervation, both in the infarct zone and the scaffold itself. In conclusion, the EMG-ATDPC and EPG-ATDPC constructs are useful tools for the treatment of myocardial infarction, demonstrating their cardioregenerative potential in porcine model, and being viable for their translation into clinical use.
Nóbrega, Fernando José de Oliveira [UNESP]. "Estudo histológico da ação do laser e da terapia fotodinâmica no processo de reparação de feridas cutâneas em ratos tratados com corticóide." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/96162.
Повний текст джерелаUniversidade Estadual Paulista (UNESP)
O processo de reparo de feridas em indivíduos imunossuprimidos pelo uso de medicação corticóide representa um problema para a área da saúde. Diversos tipos de tratamento têm sido propostos para se obter uma melhor qualidade no processo de reparo, dentre esses destaca-se o uso do laser em baixa intensidade e, mais recentemente, a terapia fotodinâmica (PDT), representada pela associação do laser com drogas fotossensibilizadoras, como o Azul de Toluidina O (TBO). O propósito deste trabalho foi avaliar, histologicamente, a ação do laser em baixa intensidade e da PDT no processso de reparo em feridas cutâneas em ratos tratados com corticóide. Foram utilizados 90 ratos, nos quais foi criada, com o auxílio de um punch, uma ferida de 8 mm de diâmetro na porção média da região dorsal. Os animais foram divididos em 5 grupos: grupo 1 (n=18): os animais não receberam nenhum tipo de tratamento, tanto local quanto sistêmico; grupo 2 (n=18): os animais receberam corticóide sistêmico e nenhum tratamento local; grupo 3 (n=18): os animais receberam sistemicamente o mesmo tratamento do grupo 2, sendo as feridas tratadas com laser de baixa intensidade; grupo 4 (n=18): os animais receberam o mesmo tratamento sistêmico do grupo 2, sendo as feridas tratadas com irrigação de TBO; e grupo 5 (n=18): os animais receberam o mesmo tratamento do grupo 4, sendo as feridas tratadas imediatamente após a sua execução, com laser em baixa intensidade. Os animais, em número de 06 (seis) para cada grupo, foram sacrificados nos períodos de 3, 7 e 14 dias após a execução dos procedimentos terapêuticos. As peças foram processadas para análise histológica e coradas pela técnica da hematoxilina e eosina (H&E) e Tricômico de Masson. Os resultados mostraram que o grupo 2 promoveu um retardo na reparação tecidual em todos os períodos experimentais...
The process of wounds repair in immunosuppressed individuals for the use of corticoid therapy represents a problem for the area of health. Several treatment types have been proposed to obtain a better quality in the repair process. Among those, the use of low level laser may be emphasized and, more recently, the photodynamic therapy (PDT), represented by the association of that laser with photosensibilized drugs like toluidine blue O (TBO). The aim of this study was to evaluate, histologically, the action of the laser and of PDT in the repair process in cutaneous wounds in rats treated with corticoid. Ninety rats were used, in which was created, with the aid of a punch of 8 mm diameter, a wound in the medium portion of the dorsal region. The animals were divided in 5 groups: group 1 (n=18): the animals didn't receive any treatment type, local or systemic; group 2 (n=18): the animals received systemic corticoid and any local treatment; group 3 (n=18): the animals received systemically the same treatment of the group 2, being the wounds treated with low level laser; group 4 (n=18): the animals received the same systemic treatment of groups 2, being the wounds treated with irrigation of TBO; and group 5 (n=18): the animals received the same treatment of the group 4, being the wounds immediately treated after their execution with laser. The animals, in number of 06 (six) for each group, were sacrificed in the periods of 3, 7 and 14 days after the execution of the therapeutic procedures. The pieces were processed for histologic analysis and colored for the technique of hematoxylin-eosin (H&E) and Masson trichrome stains. The results showed that the group 2 promoted a retard in the tissue repair in all the experimental periods; the group 3 presented a more accelerated repair process than the group 4, as well as the group 5 was presented... (Complete abstract click electronic access below)
Bossini, Paulo Sérgio. "Laser de baixa intensidade (670nm) na viabilidade do retalho cutâneo randômico em ratos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-07082007-110337/.
Повний текст джерелаSkin flaps are widely used in plastic surgery, mainly in repair surgeries. After this reconstructive procedure, one of the main consequences is the decrease of blood flow in the area, which can be responsible by tissue necrosis. In this context, a lot of studies have investigated treatments able to increase the viability of the flap and the low level laser therapy (LLLT) has been chosen as an efficient treatment to reduce post-injury inflammatory processes and to stimulate the formation of new blood vessels. However, the use of a wide range of fluences by different authors and the lack of standardized experimental conditions make it difficult to compare published results. The aim of this study was to investigate the dose-response effects of 670nm laser on the viability of random skin flap in rats. One hundred Wistar male rats were used in this study. The animals were divided into 5 groups: group 1 (control group); group 2 (treated with 3 J/\'CM POT.2\'); group 3 (treated with 6 J/\'CM POT.2\'); group 4 (treated with 12 J/\'CM POT.2\') and group 5 (treated with 24 J/\'CM POT.2\'). The skin flap was made on the back of all animals studied (dimensions: 10 x 4 cm) and before the sutures were done, a plastic sheet was interposed between the flap and the donor site. Laser irradiation was performed immediately after the surgery and on days 1, 2, 3 and 4 post-surgery. The irradiation was made punctually, on 24 points on the skin surface and around it. The percentage of the necrosis area of the flap was calculated by the paper template method at the day 7 postoperative. Moreover, a sample of the skin flaps was collected from 10 rats of each group, which were chosen aleatory, to performe the count of the blood vessels. The animals of all treated groups showed statistically significant differences when compared to the control group (necrosis area: 49, 92%). The necrosis area of the treated groups were 41,82% (group 2), 36,51% (group 3), 29,45% (group 4) and 20,37% (group 5). In the count of blood vessels, group 1 showed the mean of 65,2; group 2 - 92,6; group 3 - 105,5; group 4 - 128,7 and group 5 - 171,0. The ANOVA test, followed by the Tukey test, for multiple comparasions were used. The results showed that all experimental groups showed statistically lower values for the necrosis area compared to the control and a higher number of blood vessels in the skin flap. It can be observed that the best results were found in the animals of group 5 (p < 0,01). In addition, the Pearson coefficient showed a significant negative correlation between necrosis area and the number of vessels (-0,972 / p = 0,0001). This present study has demonstrated that the 670nm laser was efficient to increase the viability of the skin flap, at all fluences used, with a tendency of reaching better results at higher dosages (24 J/\'CM POT.2\').
Crusca, Jaqueline de Souza. "Laser de baixa intensidade no tratamento de úlceras cutâneas aplicando curativos de pericárdio porcino revestido com quitosana." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-20072012-091549/.
Повний текст джерелаLarge skin injuries represent a major public health issue, with high costs associated with the treatments. Laser therapy has been used for decades to accelerate the process of skin healing. The porcine pericardium matrix has the potential to be used as a biological dressing, but the patch has rapid biodegradation, so chitosan was added to delay this effect. Many authors have used these treatments individually; however there is no accurate data on the combination of these therapies. The aim of this study was to assess the clinical, histological and histomorphometric photobiomodulation laser action in the repair of skin ulcers associated with porcine pericardium dressing coated with chitosan. The skin ulcer was surgically induced in 48 rats, which were distributed into 6 groups with 8 animals each: Matrix (porcine pericardium dressing), ML (porcine pericardium dressing with laser therapy), MQ (porcine pericardium dressing coated with chitosan), MQL (porcine pericardium with a bandage coated with chitosan and laser therapy), Ctrl (the control group did not receive treatment) and Laser (the control group that received only laser therapy). The laser radiation groups received the treatment immediately after the surgery, with the following characteristics: light wavelength = 660nm, irradiance = 30mW/\'CM POT.2\' and of energy density 30j/\'CM POT.2\'. The photographic record of the ulcers was performed on the 10th postoperative day and to provide the ulcerated area was used the software ImageJ. We performed a histological and histomorphometric (count of fibroblasts, inflammatory cells, blood vessels and collagen) from biopsies also on the 10th postoperatively day. The results were given as means of groups from each analysis, as follows: lesion area (Laser = 0,48 \'CM POT.2\', Matriz = 0,46 \'CM POT.2\', Ctrl = 0,28 \'CM POT.2\', ML = 0,23 \'CM POT.2\', MQ = 0,22 \'CM POT.2\' e MQL = 0,19 \'CM POT.2\'), collagen formation (Laser = 54,51%, Matriz = 51,75%, Ctrl = 58,84%, ML = 68,77%, MQ = 69,50% e MQL = 71,72%), inflammatory cells (Laser = 126,31, Matriz = 132,40, Ctrl = 101,85, ML = 97,67, MQ = 95,27 e MQL = 94,15); blood vessels (Laser = 6,83, Matriz = 4,48, Ctrl = 5,37, ML = 7,46, MQ = 5,42 e MQL = 3,98) and fibroblasts (Laser = 55,83, Matriz = 71,31, Ctrl = 78,63, ML = 85,40, MQ = 105,06 e MQL = 108,58). Data were analyzed by analysis of variance with Tukey\'s post hoc to compare the groups with a significance level of 95% (p<0.05). Based on these findings, we observed that there was a statistically significant improvement in the group with porcine pericardium dressings coated with chitosan associated with the application of laser therapy (MQL) compared to control, displaying more effective in healing ulcers.