Готові списки джерел за темами / Wound healing delay

Добірка наукової літератури з теми "Wound healing delay"

Автор: Grafiati

Опубліковано: 6 вересня 2023

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Статті в журналах з теми "Wound healing delay"

Gohil, Krishna. "Lower limb wounds in diabetes: the challenges of wound healing." British Journal of Community Nursing 26, Sup9 (September 1, 2021): S20—S24. http://dx.doi.org/10.12968/bjcn.2021.26.sup9.s20.

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Managing ulceration in the lower limb for a patient with diabetes can be complex and challenging, requiring a multiprofessional, patient-centred, holistic approach with early referral for specialist review as key. Any delay in referral and intervention can be catastrophic, as time is tissue. Peripheral arterial disease and neuropathy both contribute significantly to the delays in wound healing, and it is important to rapidly recognise the problems with an informed assessment and understand the possible reasons for delayed wound healing, so that management is appropriate, rapid referrals are made and patient outcomes are optimised. This article discusses some of the reasons why wound healing is complicated in those with diabetes as a comorbidity.

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SUCKOW, MARK A., TROY A. GOBBETT, and RICHARD G. PETERSON. "Wound Healing Delay in the ZDSD Rat." In Vivo 31, no. 1 (January 5, 2017): 55–60. http://dx.doi.org/10.21873/invivo.11025.

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Mothilal K, Akila CR, Mahender K, Chaitanya Kumar K, and Ravi D. "Comparison of the ficus for the wound healing activity in various species." International Journal of Research in Phytochemistry and Pharmacology 10, no. 4 (December 12, 2020): 67–70. http://dx.doi.org/10.26452/ijrpp.v10i4.1381.

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Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.

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Roth Flach, Rachel J., and Michael P. Czech. "NETs and traps delay wound healing in diabetes." Trends in Endocrinology & Metabolism 26, no. 9 (September 2015): 451–52. http://dx.doi.org/10.1016/j.tem.2015.07.004.

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Younis, Ibby. "Role of oxygen in wound healing." Journal of Wound Care 29, Sup5b (May 1, 2020): S4—S10. http://dx.doi.org/10.12968/jowc.2020.29.sup5b.s4.

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Not only does oxygen play an essential role in each stage of the wound healing process. It also helps to increases host resistance to infection. Any impairment to the oxygen supply can therefore delay healing. This article explores the affects of oxygen on the wound cells and tissue, and explains how an adequate supply is required for granulation tissue formation and epithelialisation to occur

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Alven, Sibusiso, Vuyolwethu Khwaza, Opeoluwa O. Oyedeji, and Blessing A. Aderibigbe. "Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds." Pharmaceutics 13, no. 7 (June 26, 2021): 961. http://dx.doi.org/10.3390/pharmaceutics13070961.

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The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

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Yusuf, Ah, Ni Ketut Alit Armini, and Arina Nurfianti. "Stres Memperlambat Penyembuhan Luka Paska Seksio Sesarea." Jurnal Ners 2, no. 2 (July 23, 2017): 103–6. http://dx.doi.org/10.20473/jn.v2i2.4964.

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Introduction: Decision for cesarean section may lead to the stress for women in delivery. Stress response requires longer recovery time in post cesarean section patients. Most of patients who experience stress before and after surgical is associated with wound healing delay. When this condition continues, the wound will have a higher risk of infection. The objective of this study was to analyze correlation between stress and wound healing phase in post cesarean section patients. Method: A cross sectional design was used in this study. The population were women with cesarean section, both elective or emergency, in Delivery Room I RSU Dr. Soetomo Surabaya. Samples were recruited by using purposive sampling, with 28 samples who met to the inclusion criterias. The observed variables were stress and wound healing phase in post cesarean section patient. Stress data were collected by interview and wound healing measurement done by observation on the 3rd day post cesarean section. Result: The result showed that women with stress experience wound healing delay. The characteristic of wound healing delay was prolonged on inflammation phase, nevertheless there was presence of granulation tissue. Spearman’s rho correlation showed that correlation value r=0.675 with p=0.000. Discussion: It can be concluded that there was strong significant correlation between stress and wound healing phase in post cesarean section patients. It is important to give this information to the patients with cesarean section in order to prevent stress and delay in wound healing phase.

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Rook, Jerri M., Wohaib Hasan, and Kenneth E. McCarson. "Temporal Effects of Topical Morphine Application on Cutaneous Wound Healing." Anesthesiology 109, no. 1 (July 1, 2008): 130–36. http://dx.doi.org/10.1097/aln.0b013e31817b5ac3.

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Background Studies have shown that topical administration of exogenous opioid drugs impairs wound healing by inhibiting the peripheral release of neuropeptides, thereby inhibiting neurogenic inflammation. This delay is immediate and peaks during the first days of wound closure. This study examined the effects of topical morphine treatment in a cutaneous wound healing model in the rat. Methods Full-thickness 4-mm-diameter wounds were placed on the periscapular region of rats that subsequently received twice-daily topical applications of IntraSite Gel (Smith+Nephew, Hull, United Kingdom) alone or gel infused with 5 mm morphine sulfate on days 0-3 or 4-10 postwounding or throughout the time course. Wound tissue was taken on days 1, 3, 5, 8, and 18 postwounding and immunostained for myofibroblast and macrophage markers or stained with hematoxylin and eosin. Results Delays in wound closure observed during morphine application on days 0-3 postwounding mimicked those seen in wounds treated with morphine throughout the entire healing process. However, no significant delays in closure were seen in wounds treated with morphine beginning on day 4 postwounding. Treatment of wounds with morphine significantly reduced the number of myofibroblasts and macrophages in the closing wound. In addition, morphine application resulted in decreases in skin thickness and an increase in residual scar tissue in healed skin. Conclusions These findings demonstrate the time-dependent and persistent nature of the detrimental effects of topical morphine on cutaneous wound healing. The data identify specific limitations that could be ameliorated to optimize topical opioid administration as an analgesic therapeutic strategy in the treatment of painful cutaneous wounds.

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Borkowski, Andrew William, and Wendy L. Havran. "Epithelial and bone marrow derived sources of Cd1d contribute to wound repair." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 126.21. http://dx.doi.org/10.4049/jimmunol.196.supp.126.21.

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Abstract Wound healing is a multifaceted process that depends on both epithelial and bone marrow derived cells to promote proper healing. Recent publications have shown that a subset of T cells in the skin are activated by certain lipids bound to CD1 molecules. Cd1d, the isoform of CD1 expressed in mice, is an MHC-like molecule that binds lipid antigens and is expressed by Langerhans cells (LCs), macrophages, B cells, and wounded keratinocytes. As our lab has previously shown that T cell activation in the skin promotes wound healing, we hypothesize that Cd1d is an important component of normal wound healing. To investigate this hypothesis, we administered full thickness wounds to the dorsal skin of WT and Cd1d−/− mice and analyzed wound closure. Cd1d−/− mice had a significant delay in wound healing between days 1 and 5 compared to WT controls. Analysis of ex vivo wound healing failed to show any difference in wound closure rates between WT and Cd1d−/− skin. This suggested that an infiltrating cell type is at least partially responsible for the observed difference in in vivo wound healing. Transfer of WT bone marrow cells into lethally irradiated Cd1d−/− mice did not rescue the wound healing defect observed in Cd1d−/− mice. Interestingly, transfer of Cd1d−/− bone marrow into WT mice caused a delay in wound healing. Analysis of wounded skin demonstrated that significantly fewer macrophages and LCs were present in Cd1d−/− epidermis. We conclude that the Cd1d-mediated wound healing defect is dependent on both resident LCs and infiltrating macrophages, and continue to investigate how Cd1d expressed by LCs promotes wound repair as studies have shown that LCs have an immunosuppressive effect in models of contact hypersensitivity and UVB-induced inflammation.

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Hillman, Prima F., Chaeyoung Lee, and Sang-Jip Nam. "Microbial Natural Products with Wound-Healing Properties." Processes 11, no. 1 (December 23, 2022): 30. http://dx.doi.org/10.3390/pr11010030.

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Wound healing continues to pose a challenge in clinical settings. Moreover, wound management must be performed properly and efficiently. Acute wound healing involves multiple cell divisions, a new extracellular matrix, and the process of formation, such as growth factors and cytokines, which are released at the site of the wound to regulate the process. Any changes that disrupt the healing process could cause tissue damage and prolong the healing process. Various factors, such as microbial infection, oxidation, and inflammation, can delay wound healing. In order to counter these problems, utilizing natural products with wound-healing effects has been reported to promote this process. Several natural products have been associated with wound healing, most of which are from medicinal plants. However, secondary microbial metabolites have not been extensively studied for their wound-healing properties. Further, investigations on the wound-healing control of natural microbial products are required due to a lack of studies. This review discussed the in vivo and in vitro research on the wound healing activities of natural microbial products, which may assist in the development of better wound treatments in the future.

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Більше джерел

Дисертації з теми "Wound healing delay"

Shin, Vivian Yvonne. "A mechanistic study on the adverse effects of cigarette smoke extracts on the delay of gastric ulcer healing /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23424813.

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Shin, Vivian Yvonne, and 冼念慈. "A mechanistic study on the adverse effects of cigarette smoke extractson the delay of gastric ulcer healing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122510X.

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LeBlanc, Sarah. "CEACAM1 deficiency delays cutaneous wound healing." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66794.

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CEACAM1 (CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 1), is expressed at the surface of new blood vessels of tissues undergoing proliferation. In human tumors, CEACAM1 expression is associated with early stages of angiogenesis. CEACAM1 is a known pro-angiogenic factor, increasing VEGF activity in vivo; however, the role of CEACAM1 in angiogenesis warrants further investigation. Excisional wounds were used as an experimental model, as many of the processes that occur in healing wounds also take place in tumor growth - epithelial hyperproliferation, inflammation, and angiogenesis. 6-mm diameter skin wounds were inflicted on the dorsal side of Ceacam1-/- and wild-type mice. Upon histological examination, it was shown that wound healing in Ceacam1-/- mice is indeed delayed. In Ceacam1-/- wounds, re-epithelialization is decreased significantly at 3 and 7 days post-injury. Inflammation in Ceacam1-/- wounds is also altered: the infiltration of F4/80+ macrophages into the wound at 7 and 10 days post-injury is significantly decreased, as is the influx of mast cells at 7 days post-injury. Vascular density in Ceacam1-/- wounds is also significantly decreased at 7 and 10 days post-injury; however, VEGF expression in the wound is not altered. The results of this study not only confirm CEACAM1's role as an important factor in angiogenesis, but further expand its role as a mediator of epithelial growth and inflammation.
CEACAM1 (CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 1) est exprimé à la surface de nouveaux vaisseaux sanguins de tissus en prolifération ou de tumeurs humaines, et est associé aux stades précoces de l'angiogenèse. De plus, CEACAM1 semble être un puissant facteur angiogénique en potentialisant l'activité du VEGF in vivo. Malgré de nombreuses observations, le rôle de CEACAM1 dans l'angiogenèse normale reste à définir. Dans ce contexte, nous avons réalisé des essais de cicatrisation cutanée dans des souris Ceacam1-/-. Des plaies de 6 mm ont été effectuées sur le dos des souris. La vitesse de cicatrisation a été suivie sur 10 jours, et les plaies ont été examinées en histologie 3, 7 et 10 jours après l'essai. D'un point de vue macroscopique, la délétion de CEACAM1 n'a pas d'effet sur la cicatrisation des plaies. En revanche, des analyses plus précises en histologie montrent que la cicatrisation des souris Ceacam1 -/- est différée. En effet, le mécanisme de re-épithélisation des plaies des souris Ceacam1 -/- est retardé aux points 3 et 7 jours après blessure. De plus, l'inflammation des plaies des souris Ceacam1 -/- est également affectée : l'infiltration des macrophages F4/80+ au sein des plaies 7 et 10 jours après blessure, ainsi que celle des mastocytes au point 7 jours après blessure sont significativement diminuées. Enfin, la densité vasculaire des plaies Ceacam1-/- est également réduite de façon significative. En revanche, l'expression de VEGF au sein des plaies ne semble pas altérée. Les résultats de cette étude confirment le rôle de CEACAM1 dans l'angiogenèse, mais présentent de façon plus importante CEACAM1 comme un facteur clé dans le mécanisme de cicatrisation des plaies cutanées.

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Частини книг з теми "Wound healing delay"

Jain, Manisha, Pankaj Kumar Mishra, Ramakant Bhardwaj, and Jyoti Mishra. "Mathematical Model to Avoid Delay Wound Healing by Infinite Element Method." In Mathematical Modeling and Soft Computing in Epidemiology, 375–90. First edition. | Boca Raton, FL : CRC Press, 2021. |: CRC Press, 2020. http://dx.doi.org/10.1201/9781003038399-19.

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Das, Theerthankar, Onder Kimyon, and Michael J. Manefield. "Bacterial Biofilms on Wounds, a Major Factor That Delays Wound Healing and a Potential Threat to Human Life and Economy." In Biofilm, Pilonidal Cysts and Sinuses, 69–88. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/15695_2017_6.

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Subudhi, Praveen, Sweta Patro, and Nageswar Rao Subudhi. "Acute Hydrops and Its Management." In Eyesight and Medical Image Cognition - Recent Advances and New Perspectives [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94592.

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Acute hydrops is a well-known complication of keratoconus. It usually manifests as sudden onset loss of vision. Mostly presents in the pubertal age group. Allergic conjunctivitis associated with eye rubbing is the most substantial risk factor. Primary pathology being stromal lysis, which triggers the progression of cone, causing an undue stretch on Descemet Membrane, eventually resulting in its splitting and stromal imbibition of aqueous through these ruptures. Clinical signs are circum-cillary congestion and thick/edematous cornea with obscuration of the anterior segment. Conservative therapy delays wound healing; hence early surgical intervention is recommended globally for faster resolution of stromal edema. Long-standing corneal edema mounts to corneal perforation and neovascularisation of cornea. Compressive suture, non expansile intracameral gas injection, Deep anterior lamellar keratoplasty, and mini Descemet membrane keratoplasty are various management modalities reported in literature. Acute hydrops could be well prevented with early identification of progressive keratoconus and halting its progression.

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Тези доповідей конференцій з теми "Wound healing delay"

Rwigema, Jean-Claude, Abhay Gokhale, Michael Epperly, Julie Glowackie, Hong Wang, Tracy Dixon, Ken Patrene, Peter Wipf, and Joel S. Greenberger. "Abstract 1404: Mitochondrial-targeted nitroxide JP4-039 ameliorates irradiation-induced delay in bone wound healing and inhibits orthotopic tumor growth." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1404.

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Ziadat, John, and Karim H. Muci-Küchler. "Development of a Computational Model to Visualize Air Flow Into Surrogate Ballistic Wounds." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70650.

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In addition to the direct mechanical damage that takes place during a ballistic injury, the formation of the temporary wound cavity creates a suction effect capable of introducing debris, particles, and bacteria from the environment into the wound track. This introduction of bacterial contamination into the wound can give rise to infections which may delay healing or result in more serious problems. Various authors have conducted controlled ballistics experiments placing bacterial contamination on the surface of ballistics gelatin targets to study the effect of parameters such as projectile caliber and speed on the distribution of bacteria along the permanent cavity. The results reported in the literature showed that bacteria were present along the entire surrogate wound track. Understanding the contribution that the formation of the temporary cavity has on the number and distribution of bacteria along the surrogate wound requires the development of experiments to visualize the flow of air during the transient phase of target deformation and the use of numerical simulations to predict variables associated with the flow of air, like pressure-time histories along the projectile path, that cannot be directly measured during experiments. This paper discusses the development of a finite element model using ANSYS Autodyn for the simulation of a small caliber projectile traveling at moderate speeds penetrating a soft tissue surrogate target made of ballistics gelatin. The model uses a Coupled Eulerian-Lagrangian formulation and discretization scheme, which allows for the analysis of not only the deformation of the solid bodies, but also of the flow of air into the wound track. For model validation, the numerical results are compared to spatial data extracted from high speed video recorded during experiments matching key model parameters. Comparisons of the numerical and experimental results indicate that the model is providing reasonable results for the deformations and overall air flow. The predicted pressure dynamics within the simulated wound track clearly suggest that areas of partial vacuum exist within the cavity, which is consistent with the suction effect mentioned by several researchers.

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Sfakianakis, Eleftherios, Foivos Irakleidis, and Peng Tan. "“NO DRAIN” AND DAY-CASE MASTECTOMY AND AXILLARY SURGERY: OUR EXPERIENCE." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2062.

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Background: Seroma formation is the most common complication following breast cancer and axillary surgery, with incidence ranging from 15% to 85%. Delayed wound healing, discomfort, infection, and delay in starting adjuvant therapies are the main complications following seroma formation. Several factors have been considered responsible for seroma; however, its pathogenesis is not yet fully understood. Despite the fact that there is no clear evidence that the use of drain reduces the incidence of seroma formation, closed suction drainage following mastectomy and axillary lymph node clearance remains the standard of practice for most of the breast surgeons in the UK. Patients’ discomfort, wound infection, and prolonged hospital stay are the major drawbacks of drain surgery. Objective: The aim of this study is to present and evaluate our experience in no drain mastectomy combined with axillary surgery. Methodology: Patients who underwent a simple mastectomy and axillary surgery from January 2017 to January 2021 for breast cancer were divided by a single oncoplastic breast surgeon in a tertiary Breast Unit in London, UK, into mastectomy and sentinel lymph node biopsy and axillary clearance subgroups. Parameters such as patients’ demographics, performance status, tumor characteristics, hospital stay, drain status, and complications were evaluated. Mastectomy flaps were dissected using electrocautery, with thoroughly sealing of the lymphatics, and were fixed onto the chest wall with polyglactin 910 sutures, and an axillary cavity was closed by suturing clavipectoral fascia to prevent seroma formation. No drain was used in either subgroup of patients apart from a single case with bleeding disorders. Results: A total of 52 patients (51 females and 1 male) underwent mastectomy and axillary surgery. Of these, 32 patients had axillary clearance (axillary lymph node clearance [ALND]) and 19 had sentinel lymph node biopsy (SLNB). Of the 52 patients, 9 were 60 years old. Performance status (ASA score) was as follows: ASA I: 20 patients, ASA II: 20, ASA III: 10, and ASA IV: 2 patients. A total of 42 patients had day surgery (24 in the ALND and 18 in the SLNB subgroup). The medial number of lymph node retrieval was 2.6 and 13.6 in the SLNB and ALND, respectively. In terms of complications, three patients developed seroma in the early post-op period (two in the ALND and one in the SLNB subgroup), two patients had wound infection treated with antibiotics, and three had hematoma treated conservatively. Conclusion: Despite the lack of clear evidence that drain reduces the incidence of seroma, the use of drain is widely accepted among surgeons when mastectomy is performed with either SLNB or axillary clearance. The data demonstrate that no drain and day-case approach in mastectomy combined with axillary surgery can be safely performed even in patients with axillary clearance, with minimum complication rates. Sealing of the lymphatics with electrocautery combined with the fixation of mastectomy skin flaps on the chest wall with plication sutures and closure of axillary dead space seems to be efficient in seroma prevention.

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