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1
Bellingeri, Paolo, and Arthur Soulié. "A note on representations of welded braid groups." Journal of Knot Theory and Its Ramifications 29, no. 12 (October 2020): 2050082. http://dx.doi.org/10.1142/s0218216520500820.
Анотація:
In this paper, we adapt the procedure of the Long-Moody procedure to construct linear representations of welded braid groups. We exhibit the natural setting in this context and compute the first examples of representations we obtain thanks to this method. We take this way also the opportunity to review the few known linear representations of welded braid groups.
2
Dey, Soumya, and Krishnendu Gongopadhyay. "Commutator subgroups of welded braid groups." Topology and its Applications 237 (March 2018): 7–20. http://dx.doi.org/10.1016/j.topol.2018.01.003.
3
KAUFFMAN, LOUIS H., and SOFIA LAMBROPOULOU. "VIRTUAL BRAIDS AND THE L-MOVE." Journal of Knot Theory and Its Ramifications 15, no. 06 (August 2006): 773–811. http://dx.doi.org/10.1142/s0218216506004750.
Анотація:
In this paper we prove a Markov theorem for virtual braids and for analogs of this structure including flat virtual braids and welded braids. The virtual braid group is the natural companion to the category of virtual knots, just as the Artin braid group is the natural companion to classical knots and links. In this paper we follow L-move methods to prove the Virtual Markov theorems. One benefit of this approach is a fully local algebraic formulation of the theorems in each category.
4
Bardakov, Valeriy G., Yuliya A. Mikhalchishina, and Mikhail V. Neshchadim. "Representations of virtual braids by automorphisms and virtual knot groups." Journal of Knot Theory and Its Ramifications 26, no. 01 (January 2017): 1750003. http://dx.doi.org/10.1142/s0218216517500031.
Анотація:
In the present paper, a new representation of the virtual braid group [Formula: see text] into the automorphism group of free product of the free group and free abelian group is constructed. This representation generalizes the previously constructed ones. The fact that the previously known representations are not faithful for [Formula: see text] is verified. Using representations of [Formula: see text], a virtual link group is defined. Also representations of the welded braid group [Formula: see text] are constructed and the welded link group is defined.
5
Bardakov, Valeriy G., Krishnendu Gongopadhyay, and Mikhail V. Neshchadim. "Commutator subgroups of virtual and welded braid groups." International Journal of Algebra and Computation 29, no. 03 (May 2019): 507–33. http://dx.doi.org/10.1142/s0218196719500127.
Анотація:
Let [Formula: see text], respectively [Formula: see text] denote the virtual, respectively welded, braid group on [Formula: see text]-strands. We study their commutator subgroups [Formula: see text] and, [Formula: see text], respectively. We obtain a set of generators and defining relations for these commutator subgroups. In particular, we prove that [Formula: see text] is finitely generated if and only if [Formula: see text], and [Formula: see text] is finitely generated for [Formula: see text]. Also, we prove that [Formula: see text] and for [Formula: see text] the commutator subgroups [Formula: see text] and [Formula: see text] are perfect, i.e. the commutator subgroup is equal to the second commutator subgroup.
6
Chterental, Oleg. "Virtual braids and virtual curve diagrams." Journal of Knot Theory and Its Ramifications 24, no. 13 (November 2015): 1541001. http://dx.doi.org/10.1142/s0218216515410011.
Анотація:
There is a well-known injective homomorphism [Formula: see text] from the classical braid group [Formula: see text] into the automorphism group of the free group [Formula: see text], first described by Artin [Theory of Braids, Ann. Math. (2) 48(1) (1947) 101–126]. This homomorphism induces an action of [Formula: see text] on [Formula: see text] that can be recovered by considering the braid group as the mapping class group of [Formula: see text] (an upper half plane with [Formula: see text] punctures) acting naturally on the fundamental group of [Formula: see text]. Kauffman introduced virtual links [Virtual knot theory, European J. Combin. 20 (1999) 663–691] as an extension of the classical notion of a link in [Formula: see text]. There is a corresponding notion of a virtual braid, and the set of virtual braids on [Formula: see text] strands forms a group [Formula: see text]. In this paper, we will generalize the Artin action to virtual braids. We will define a set, [Formula: see text], of “virtual curve diagrams” and define an action of [Formula: see text] on [Formula: see text]. Then, we will show that, as in Artin’s case, the action is faithful. This provides a combinatorial solution to the word problem in [Formula: see text]. In the papers [V. G. Bardakov, Virtual and welded links and their invariants, Siberian Electron. Math. Rep. 21 (2005) 196–199; V. O. Manturov, On recognition of virtual braids, Zap. Nauch. Sem. POMI 299 (2003) 267–286], an extension [Formula: see text] of the Artin homomorphism was introduced, and the question of its injectivity was raised. We find that [Formula: see text] is not injective by exhibiting a non-trivial virtual braid in the kernel when [Formula: see text].
7
Bardakov, Valeriy G., and Paolo Bellingeri. "Groups of virtual and welded links." Journal of Knot Theory and Its Ramifications 23, no. 03 (March 2014): 1450014. http://dx.doi.org/10.1142/s021821651450014x.
Анотація:
We define a new notion of group of virtual and welded links. We use two approaches for defining it: via representations of (generalized) braids by automorphisms of free groups and via Wirtinger-like labeling on virtual and welded diagrams. In the case of virtual links our invariant is stronger than the notion of fundamental group of a virtual link introduced by Kauffman. In the case of welded links our invariant coincides with Kauffman invariant, but using a generalization of Wada representations we provide new families of invariants of welded links.
8
BARTHOLOMEW, ANDREW, and ROGER FENN. "BIQUANDLES OF SMALL SIZE AND SOME INVARIANTS OF VIRTUAL AND WELDED KNOTS." Journal of Knot Theory and Its Ramifications 20, no. 07 (July 2011): 943–54. http://dx.doi.org/10.1142/s0218216511009042.
Анотація:
In this paper we give the results of a computer search for biracks of small size and we give various interpretations of these findings. The list includes biquandles, racks and quandles together with new invariants of welded knots and examples of welded knots which are shown to be non-trivial by the new invariants. These can be used to answer various questions concerning virtual and welded knots. As an application we reprove the result that the Burau map from braids to matrices is non-injective and give an example of a non-trivial virtual (welded) knot which cannot be distinguished from the unknot by any linear biquandles.
9
KLYMOV, Yulii, and Igor BOYKO. "STRENGTH OF BUTT WELDED BUTT JOINT OF REINFORCEMENT OF CLASS A500C." Building constructions. Theory and Practice, no. 10 (June 27, 2022): 79–93. http://dx.doi.org/10.32347/2522-4182.10.2022.79-93.
Анотація:
The paper presents the results of experimental studies of the strength of the butt welded joint type C1-Кo for thermo-mechanically reinforced reinforcement class A500C.The experimental studies included tensile tests of two series of reinforcement specimens, each of which included reinforcement specimens in the initial state and with a butt contact weld of the C1-Сo type.The first series included fittings Ø12A500C, Ø14A500C, Ø16A500C from steel of the ST3ps brand and Ø18A500C, Ø20A500C, Ø22A500Cfrom steel of the Ст3пс brand. A total of 278 samples of welded joints were tested. The second series included samples of C1-Co welded joints from the rest of the nomenclature of diameters and grades of steel reinforcement class A500C, namely Ø16A500C from steel grade St3ps, Ø20A500C, Ø22A500C from steel grade St3Gps and Ø25A500C, Ø32A500C, Ø32A500C, Ø32A500C.For each of the diameters, 6 samples were tested in the initial state and 6 samples of C1-Co welded joints.It was found that the destruction of the butt contact connection type C1-Co thermomechanically reinforced reinforcement class A500C of all diameters, from 12 to 32 mm, and steel grades, takes placein the zone of thermal impact and is plastic. Experimental data on the strength of the butt contact weld type C1-Кo reinforcement classA500C for the entire range of diameters and grades of steel produced in Ukraine. It is established that the greatest degree of hardening within 19-20% takes place at diameters of armature of 12… 16 mm from steel of the Ст3пс brand, at diameters of armature of 18… 22 mm from steel of the Ст3Гпс brand of marking made 15-17%, and at diameters of 25…32 mm from steel of the 25Г2С brand - 2,
10
Darné, Jacques. "Milnor invariants of braids and welded braids up to homotopy." Algebraic & Geometric Topology 24, no. 3 (June 28, 2024): 1277–320. http://dx.doi.org/10.2140/agt.2024.24.1277.
11
KLYMOV, Yulii. "STRENGTH OF BUTT WELDED BUTT JOINT OF REINFORCEMENT OF CLASS A500C." Building constructions. Theory and Practice, no. 11 (December 26, 2022): 4–17. http://dx.doi.org/10.32347/2522-4182.11.2022.4-17.
Анотація:
The paper presents the results of experimental studies of the strength of cross-shaped welded joints of types К1-Кт and К3-Рр [1] of thermomechanically hardened reinforcement of class A500C [2] for hardening during welding of the main bar [3].
Experimental studies included testing three series of samples of welded joints and reinforcement samples in the initial state. The first series included testing welded joints of type К1-Кт to strengthen the main bar during welding. Reinforcement Ø14A500С was accepted as the main (working) bar, and reinforcement Ø12A500С and Ø8A240С were accepted as the transverse bar. For each joints, 6 samples were tested on the lower and upper limits of the carbon equivalent values of the grade steel class Ст3пс, 0.245% and 0.346%, respectively. The second series included testing of welded joints of the K3-Pp type to strengthen the main bar during welding. To directly compare the test results of different types of cross-shaped welded joints, the diameter of the main and transverse rods, the number of samples and the value of equivalent were the same as in the first series. The third series included testing welded joints of type К1-Кт for cutting. Reinforcement Ø14A500С was taken as a longitudinal bar, and reinforcement Ø12A500С and Ø8A500С was taken as a transverse rod. For each joints, 12 samples were tested at the lower and upper limits of the carbon equivalent values.
As a result of testing samples of welded joints of types К1-Кт and К3-Рр of reinforcement A500C for strengthening during welding, it was established that the destruction occurs along the main bar and in the zone of thermal exposure, the amount of hardening was up to 4% for the К1-Кт compound, and for the К3-Рр type connection - 4... 10%.
Failure of samples of welded joints of type К1-Кт reinforcement A500C with reinforcement Ø12A500C and Ø8A240C during the cut test usually occurred in the zone of thermal exposure, or in some cases, in the presence of both rods from reinforcement of class A500C - directly at the welding site. The average value of cut strength for a sample of 24 samples of reinforcement connections of class A500C with reinforcement A240C was 356.5 MPa, or 0.89 of the temporary resistance of the reinforcement in the initial state, with a coefficient of variation - 0.08 and a span of 107.4 MPa. The average cut strength for a sample of 24 samples of reinforcement connections of class A500C with reinforcement A500C was 541.1 MPa, or 0.80 of the temporary resistance of the reinforcement in the initial state, with a coefficient of variation – 0.152 and a span of 280.0 MPa.
The first series included fittings Ø12A500C, Ø14A500C, Ø16A500C from steel of the ST3ps brand and Ø18A500C, Ø20A500C, Ø22A500C from steel of the Ст3пс brand. A total of 278 samples of welded joints were tested. The second series included samples of C1-Co welded joints from the rest of the nomenclature of diameters and grades of steel reinforcement class A500C, namely Ø16A500C from steel grade St3ps, Ø20A500C, Ø22A500C from steel grade St3Gps and Ø25A500C, Ø32A500C, Ø32A500C, Ø32A500C. For each of the diameters, 6 samples were tested in the initial state and 6 samples of C1-Co welded joints.
It was found that the destruction of the butt contact connection type C1-Co thermomechanically reinforced reinforcement class A500C of all diameters, from 12 to 32 mm, and steel grades, takes place in the zone of thermal impact and is plastic.
Experimental data on the strength of the butt contact weld type C1-Кo reinforcement class A500C for the entire range of diameters and grades of steel produced in Ukraine. It is established that the greatest degree of hardening within 19-20% takes place at diameters of armature of 12… 16 mm from steel of the Ст3пс brand, at diameters of armature of 18… 22 mm from steel of the Ст3Гпс brand of marking made 15-17%, and at diameters of 25… 32 mm from steel of the 25Г2С brand - 2,5… 8%.
12
Konoplin, A. Yu, A. V. Pushkarev, A. V. Shakurov, and N. I. Baurova. "Evaluation of resistance of silicone sealant to ultralow temperature effect." Adhesives. Sealants. Technologias, no. 1 (January 2021): 22–27. http://dx.doi.org/10.31044/1813-7008-2021-0-1-22-27.
Анотація:
Properties of the silicone sealant VGO-1 have been examines, which is used for production of glue-welded joints made by contact welding. Conditions to produce glue-welded joints are described. It was found out that when welding steel specimens of the 08kp brand on the VGO-1 sealant there was a decrease in a welding current value and an increase in welding time and the electrode compression force. The study of sealant structures after storage at different temperatures demonstrated that the used sealant had good resistance at –30 °С in the air environment and satisfactory resistance at –50 °С in a liquid environment. The swelling index of the sealant after 20 day storage in medicinal ethyl alcohol was no more than 4.5%.
13
Biloborodchenko, Volodymyr, Andrii Dzyubyk, and Liudmyla Dzyubyk. "Design-technological optimization of the level of residual deformations during welding of pipe sections from PT-7M alloy." Ukrainian Journal of Mechanical Engineering and Materials Science 7, no. 1-2 (2021): 43–53. http://dx.doi.org/10.23939/ujmems2021.01-02.043.
Анотація:
The use of tubular elements in the chemical industry is widely used. The special properties of materials and their reaction to the welding thermal cycle is quite complex. This is especially true of titanium alloys, which when heated are sensitive to environmental influences, require special welding techniques and undergo residual welding deformations. The welded joints of tubular elements made of titanium alloy brand PT-7m, which undergo transverse deformations due to welding, are studied. It is necessary to ensure high-quality sealed welds. Analysis of the literature has shown that to obtain a guaranteed penetration it is necessary to increase the power of the arc discharge or perform multi-pass welding. This will provide larger cross sections of welded parts and should provide the specified strength characteristics. However, this technology, in turn, leads to an increase in residual deformation in the vicinity of the welded joint due to the intensive increase in the coefficient of linear expansion when heating the material. Also, the special thermophysical properties of titanium alloy such as increasing the affinity for gases when heated, increasing the grain size lead to a decrease in strength properties. In the presented work it is proposed to use a mechanical angular deformer with an indicator head and a reference base for the study of transverse residual deformations. Peculiarities of measuring sockets and methods of their preparation are revealed. A calculation scheme for determining the amount of deformation has been developed, which has been tested on flat welded specimens and transferred to tubular elements. The sequence of deformation measurement process is described and the peculiarities of their formation on flat samples and tubular sections are studied. The constructive decision of a welded joint of pipes which provides use of a compensation ring is offered. This approach allows to provide reliable protection of the root of the seam and its optimal formation with minimal residual deformation. At the same time it is possible to reach the reproducible form of a dagger of similar penetration in one pass. The result is a welded joint of the lock type, which is sealed and has a free formation of the seam root with high-quality protection by the gas atmosphere. The use of pulsed arc welding with a non-fusible electrode in an argon environment with filler wire allows to minimize the thermal impact on the base metal. Statistical processing of experimental data on the parameters of the welding mode and their influence on the residual transverse welding deformations is carried out. To obtain an unambiguous statistically reliable answer about the valid law of distribution of experimental data of the results of strain measurement, the balancing procedure and the development of an analytical approximation distribution model are involved. It is shown that the measured values of the residual transverse deformation of the welded assembly are correctly described by the Laplace distribution, which predicts (probability not worse than 90 %) a decrease in the average value of the deformation value by 1.3 times.
14
Mesquita, Tatyane Ribeiro, Lídia Parsekian Martins, and Renato Parsekian Martins. "Welding strength of NiTi wires." Dental Press Journal of Orthodontics 23, no. 3 (June 2018): 58–62. http://dx.doi.org/10.1590/2177-6709.22.3.058-062.oar.
Анотація:
ABSTRACT Objective: To identify the appropriate power level for electric welding of three commercial brands of nickel-titanium (NiTi) wires. Methods: Ninety pairs of 0.018-in and 0.017 × 0.025-in NiTi wires were divided into three groups according to their manufacturers - GI (Orthometric, Marília, Brazil), GII (3M OralCare, St. Paul, CA) and GIII (GAC,York, PA) - and welded by electrical resistance. Each group was divided into subgroups of 5 pairs of wires, in which welding was done with different power levels. In GI and GII, power levels of 2.5, 3, 3.5, 4, 4.5 and 5 were used, while in GIII 2.5, 3, 3.5 and 4 were used (each unit of power of the welding machine representing 500W). The pairs of welded wires underwent a tensile strength test on an universal testing machine until rupture and the maximum forces were recorded. Analysis of variance (ANOVA) and post-hoc tests were conducted to determine which subgroup within each brand group had the greatest resistance to rupture. Results: The 2.5 power exhibited the lowest resistance to rupture in all groups (43.75N for GI, 28.41N for GII and 47.57N for GIII) while the 4.0 power provided the highest resistance in GI and GII (97.90N and 99.61N, respectively), while in GIII (79.28N) the highest resistance was achieved with a 3.5 power welding. Conclusions: The most appropriate power for welding varied for each brand, being 4.0 for Orthometric and 3M, and 3.5 for GAC NiTi wires.
15
Kim, Yangho. "Decreased brain volumes in manganese-exposed welders." Neurotoxicology and Teratology 49 (May 2015): 148. http://dx.doi.org/10.1016/j.ntt.2015.04.154.
16
Kim, Yangho. "Decreased brain volumes in manganese-exposed welders." Neurotoxicology and Teratology 49 (May 2015): 148–49. http://dx.doi.org/10.1016/j.ntt.2015.04.155.
17
Chang, Yongmin, Seong-Uk Jin, Yangho Kim, Kyung Min Shin, Hui Joong Lee, Suk Hwan Kim, Joon-Ho Ahn, et al. "Decreased brain volumes in manganese-exposed welders." NeuroToxicology 37 (July 2013): 182–89. http://dx.doi.org/10.1016/j.neuro.2013.05.003.
18
Glotka, Alexander, and Vadim Ol'shanetskii. "MODELING OF CARBIDES COMPOSITION IN WELDED ALLOY SYSTEM Ni-34Cr-4,3W-2,3Mo-1,3Al-1,3Ti-1,3Nb-0,1C." Acta Metallurgica Slovaca 27, no. 3 (September 13, 2021): 157–61. http://dx.doi.org/10.36547/ams.27.3.1049.
Анотація:
In this work, theoretical modeling of the thermodynamic processes of the release of excess phases is carried out, as well as a practical study of the structure and distribution of chemical elements in carbides, depending on alloying using a scanning electron microscope. The obtained dependences were experimentally confirmed using X-ray spectroscopy on nickel-based superalloys. It is recommended to use the obtained mathematical models not only in the design of new nickel-based superalloys, but also in the improvement of known brand compositions within the declared concentrations.
19
Муктепавел, В. О., В. М. Карпов, and И. Г. Струков. "Technological methods for creating permanent joints of dissimilar materials." MORSKIE INTELLEKTUAL`NYE TEHNOLOGII)</msg>, no. 4(58) (December 2, 2022): 117–22. http://dx.doi.org/10.37220/mit.2022.58.4.015.
Анотація:
В статье представлены результаты отработки технологий соединения титанового сплава с пермендюром, что высоко актуально при изготовлении магнитострикционных преобразователей для ультразвуковой ударной обработки сварных соединений. Рассмотрены варианты получения неразъемных соединений различными способами пайки, сварки и механическим обжимом. Ударным характером работы обоснована предпочтительность изготовления паяных либо сварных магнитострикторов. Приведены режимы для бесфлюсовой пайки в вакууме серебросодержащими припоями, аморфными припоями марки СТЕМЕТ (1202 и 1403) и диффузионной сварки через прослойку медьсодержащей ленты ЛМП-2 (изготовленной прессованием ультрадисперсного порошка). Для приведенных режимов были проведены механические испытания образцов, показавшие, что разрушение происходило по основному металлу – пермендюру. Результаты могут быть использованы для решения данной технологической задачи, а также (при проведении дополнительных исследований) для решения аналогичных проблем получения неразъемных соединений из разнородных сплавов, которые должны работать в условиях ударных знакопеременных циклических нагрузок. The article presents the results of the development of technologies for joining a titanium alloy with a permendyur (49Co49Fe2V), which is highly relevant in the manufacture of magnetostrictive transducers for ultrasonic impact treatment of welded joints. The options for obtaining permanent joints by various methods of soldering, welding and mechanical crimping are considered. The impact nature of the work substantiates the preference for manufacturing brazed or welded magnetostrictors. The modes for flux-free soldering in vacuum with silver-containing solders, amorphous solders of the STEMET brand (1202 and 1403) and diffusion welding through the layer of copper-containing tape LMP-2 (made by pressing ultrafine powder) are given. For the given regimes, mechanical tests of the samples were carried out, which showed that the destruction occurred along the base metal - permendyur. The results can be used to solve this technological problem, as well as (with additional research) to solve similar problems of obtaining permanent joints from dissimilar alloys, which must work under conditions of shock alternating cyclic loads.
20
Galletti, Cosimo, Francesco Freni, Francesco Ciodaro, and Bruno Galletti. "Congenital bilateral choanal atresia: an endoscopic approach with multi-flaps supported by neuronavigated CT." BMJ Case Reports 14, no. 11 (November 2021): e245815. http://dx.doi.org/10.1136/bcr-2021-245815.
Анотація:
We present a case of a 2-month-old patient with CHARGE syndrome, cerebral haemorrhage and bilateral congenital choanal atresia (CCA). He was admitted to our otorhinolaryngology unit to solve his congenital bilateral choanal atresia proposing a transnasal endoscopic surgery. A study of CT of the skull showed that the air column was interrupted on both sides of nasal cavities; a nasal endoscopy with neonatology flexible optics showed the presence of a membrane and bony structure obstructing the passage into the nasopharynx. Preoperative brain magnetic resonance (MRN) has been made. We decided to carry out a transnasal endoscopic neuronavigation approach with multi-flaps without stenting apposition to solve the CCA, using a 0° 2.7-millimetre rigid endoscopic and Skeeter-type drill with a 2.3-millimetre microblade cutter. Postoperative nasal care was essential to avoid recurrences. Endoscopic follow-up was performed; a large uni-neochoane was residual at 3 months, all raw surfaces were covered by multiple mucosal flaps welded with fibrin.
21
Edmondson, David A., Chien-Lin Yeh, Sébastien Hélie, and Ulrike Dydak. "Whole-brain R1 predicts manganese exposure and biological effects in welders." Archives of Toxicology 94, no. 10 (September 1, 2020): 3409–20. http://dx.doi.org/10.1007/s00204-020-02839-7.
22
Edmondson, David A., Ruoyun E. Ma, Chien-Lin Yeh, Eric Ward, Sandy Snyder, Elham Azizi, S. Elizabeth Zauber, Ellen M. Wells, and Ulrike Dydak. "Reversibility of Neuroimaging Markers Influenced by Lifetime Occupational Manganese Exposure." Toxicological Sciences 172, no. 1 (August 6, 2019): 181–90. http://dx.doi.org/10.1093/toxsci/kfz174.
Анотація:
Abstract Manganese (Mn) is a neurotoxicant that many workers are exposed to daily. There is limited knowledge about how changes in exposure levels impact measures in magnetic resonance imaging (MRI). We hypothesized that changes in Mn exposure would be reflected by changes in the MRI relaxation rate R1 and thalamic γ-aminobutyric acid (GABAThal). As part of a prospective cohort study, 17 welders were recruited and imaged on 2 separate occasions approximately 2 years apart. MRI relaxometry was used to assess changes of Mn accumulation in the brain. Additionally, GABA was measured using magnetic resonance spectroscopy in the thalamic and striatal regions of the brain. Air Mn exposure ([Mn]Air) and cumulative exposure indexes of Mn (Mn-CEI) for the past 3 months (Mn-CEI3M), past year (Mn-CEI12M), and lifetime (Mn-CEILife) were calculated using personal air sampling and a comprehensive work history, whereas toenails were collected for analysis of internal Mn body burden. Finally, welders’ motor function was examined using the Unified Parkinson’s Disease Rating Scale (UPDRS). Median exposure decreased for all exposure measures between the first and second scan. ΔGABAThal was significantly correlated with ΔMn-CEI3M (ρ = 0.66, adjusted p = .02), ΔMn-CEI12M (ρ = 0.70, adjusted p = .006), and Δ[Mn]Air (ρ = 0.77, adjusted p = .002). ΔGABAThal significantly decreased linearly with ΔMn-CEI3M (quantile regression, β = 15.22, p = .02) as well as Δ[Mn]Air (β = 1.27, p = .04). Finally, Mn-CEILife interacted with Δ[Mn]Air in the substantia nigra where higher Mn-CEILife lessened the ΔR1 per Δ[Mn]Air (F-test, p = .005). Although R1 and GABA changed with Mn exposure, UPDRS was unaffected. In conclusion, our study shows that effects from changes in Mn exposure are reflected in thalamic GABA levels and brain Mn levels, as measured by R1, in most brain regions.
23
Sanderson, KJ. "Neurogenesis in the olfactory sytem of the brushtail possum Trichosurus vulpecula." Australian Mammalogy 27, no. 2 (2005): 217. http://dx.doi.org/10.1071/am05217.
Анотація:
A series of developmental studies of the brushtail possum (Trichosurus vulpecula) have described much of the postnatal neurogenesis in the brain of this species (Sanderson and Aitkin 1990; Sanderson and Weller 1990a,b; Harman et al. 1992; Sanderson and Wilson 1997) except in the olfactory system. The olfactory epithelium is well developed at birth (Hall and Hughes 1987). This study provides a brief report of neuronal birth in the olfactory system, using the same anatomical material from the previous studies.
24
Hong, Young Seoub, Jung Il Kim, Kap Yeol Jung, and Joon Youn Kim. "Study on Clinical Significance of High Signal Intensity by Brain Magnetic Resonance Imaging in Mild Steel/Arc Welders (Clinical Significance of High Signal Intensity by Brain MRI in Welders)." Korean Journal of Occupational and Environmental Medicine 11, no. 3 (1999): 415. http://dx.doi.org/10.35371/kjoem.1999.11.3.415.
25
Sen, Suman, Michael R. Flynn, Guangwei Du, Alexander I. Tröster, Hongyu An, and Xuemei Huang. "Manganese Accumulation in the Olfactory Bulbs and Other Brain Regions of “Asymptomatic” Welders." Toxicological Sciences 121, no. 1 (February 9, 2011): 160–67. http://dx.doi.org/10.1093/toxsci/kfr033.
26
Seifert, Volker, and Dietmar Stolke. "Laser-Assisted Reconstruction of the Oculomotor Nerve: Experimental Study on the Feasibility of Cranial Nerve Repair." Neurosurgery 25, no. 4 (October 1, 1989): 579–83. http://dx.doi.org/10.1227/00006123-198910000-00011.
Анотація:
Abstract In this experimental study the feasibility of microsurgical laser-assisted repair of the oculomotor nerve in the cat was investigated. The 3rd cranial nerve was explored after a temporobasal craniectomy from its exit at the brain stem to its entrance into the cavernous sinus and transected. The cut nerve ends were loosely reapproximated and welded together with a CO2milliwatt laser using a power setting of 80 to 90 mW and a spot size of 150 M. Regeneration of the oculomotor nerve within an observation period of 12 months as assessed by weekly examination of the pupil diameter was excellent in 4 animals and satisfactory in 2. In the two control groups consisting of 6 animals in which the nerve reconstruction had been performed with fibrin glue or by simple nerve reapproximation minimal nerve regeneration could be observed only in one animal. The histomorphological examinations revealed good regeneration across the laser anastomosis including new formation of a perineural sheath without any significant scarring effect or constriction at the anastomotic site. It is concluded that the CO2milliwatt laser might be a useful tool for the microsurgical repair of cranial nerves and should possibly be incorporated into the neurosurgical armamentarium of reconstructive cranial nerve surgery.
27
Imam, Imam kholiq Imam. "PERANCANGAN MEJA PUTAR ROLL WELDING SEBAGAI ALAT BANTU PENGELASAN (STUDI KASUS : ART WELDING PT. MECO INOXPRIMA)." MATRIK 20, no. 1 (September 30, 2019): 57. http://dx.doi.org/10.30587/matrik.v20i1.952.
Анотація:
Welding that produces a quality connection and is very possible to connect metal by welding in various shapes and positions. Therefore the welding process must require a practical material supporting device and in accordance with the needs of all welding positions which will facilitate and provide welder comfort in welding. So that the results of maximum and quality welds (good hasis las visually) are produced in this study the type of connection used is angular joints with the aim of designing and making tools to get the results of welding joints and comparing the distortions that occur between using desk tools rotate and without using tools. In this study Gtaw welding was used with the brand DC ARC WELDER with type Bz-300F-3 and filler type ER 308L, Voltage 20-30 V, travel speed 60 mm / min and variations of Flow (A) namely 100 A, 125 A and 150 A. with a diameter of 2.4 mm as a filler. The study was limited to the design and manufacture of tools and measurements of distortion carried out 20 times. Distortion measurement uses a dial indicator with a starting point / zero point on the end of the test object and the end point in the weld joint area. The results show that the use of roll welding tools can reduce the occurrence of distortion. The smallest value of distortion is obtained using a roll welding rotary table tool which is equal to 0.33 degrees, while the smallest value of distortion without using roll welding is 1.33 degrees. And the use of roll welding rotary table aids can reduce welding defects reduce setup time and can increase production volume which results in a decrease in production costs, making it quite feasible and efficient in terms of the economy.
28
Yim, Hyeon Woo, Ji Hong Kim, Young Gyu Phee, Jung Wan Koo, Kang Sook Lee, Chung Yill Park, Jeong Wook Lee, Si Ryung Han, and Hye Suk Jang. "An Association between Brain MRI and Neurologic Findings in Welders Exposed to Manganese Fume." Korean Journal of Occupational and Environmental Medicine 10, no. 2 (1998): 161. http://dx.doi.org/10.35371/kjoem.1998.10.2.161.
29
Kim, KW, MA Lim, MY Shon, SH Lee, DG Ha, KR Kwon, SS Kim, YS Hong, YH Lee, and HK Cheong. "Brain MRI Findings of Welders: High Signal Intensity in T1W1 Secondary to Manganese Exposure." Journal of the Korean Radiological Society 38, no. 3 (1998): 403. http://dx.doi.org/10.3348/jkrs.1998.38.3.403.
30
Lee, Eun-Young, Michael R. Flynn, Mechelle M. Lewis, Richard B. Mailman, and Xuemei Huang. "Welding-related brain and functional changes in welders with chronic and low-level exposure." NeuroToxicology 64 (January 2018): 50–59. http://dx.doi.org/10.1016/j.neuro.2017.06.011.
31
Hong, Young Seoub, Myung Ah Lim, Yong Hee Lee, Hae Kwan Cheong, Ji Yong Kim, Hyun Sul Lim, Jung Jeung Lee, Kong Joon Sa, and Joon Youn Kim. "Three Cases of High Signal Intensity by Brain Magnetic Resonance Imaging in CO2 arc Welders." Korean Journal of Occupational and Environmental Medicine 10, no. 2 (1998): 290. http://dx.doi.org/10.35371/kjoem.1998.10.2.290.
32
Woerner, Markus H., and Ricca Edmondson. "Forming Diagnostic Opinions." Rhetorik 37, no. 1 (November 1, 2018): 68–93. http://dx.doi.org/10.1515/rhet.2018.005.
Анотація:
Abstract Using an understanding of rhetoric as a method of communicative reasoning capable of providing grounds for conviction in those to whom it is addressed, this article argues that the formation of medical diagnoses shares a structure with Aristotle’s account of the rhetorical syllogism (the enthymeme). Here the argument itself (logos), together with characterological elements (ethos) and emotions (pathos), are welded together so that each affects the operation of the others. In the initial three sections of the paper, we contend, first, that diagnoses, as verdictive performatives, differ from scientific claims in being irreducibly personal and context-dependent; secondly, that they fit the structure of voluntary action as analysed by Aristotle and Aquinas; thirdly, that as practical syllogisms they differ from theoretical syllogisms, for example in taking effect in action, being ›addressed‹, and being intrinsically embedded in wider contexts of medical communication and practices. In the remaining sections we apply this account to textual evidence about diagnosis, drawing on work by the brain surgeon Henry Marsh. A rhetorical analysis of his observations on the formation of diagnostic opinions in situilluminates how moral, social and emotional features are fused with the cognitive aspects of medical judgement, making or marring how diagnoses and treatment are enacted. In other words, a philosophical- rhetorical account of diagnosis can help us to appreciate how medical diagnosis takes effect. We briefly conclude with some implications of our work for how diagnostic processes could in practice be better supported.
33
Strelnikov, I. V., K. E. Ponomarev, and A. A. Antonov. "To the question of the application of vibrational treatment for brand and whiplash welded compounds from aluminum alloy AMG6 during welding and after its completion." Welding and Diagnostics, no. 3 (2021): 57–60. http://dx.doi.org/10.52177/2071-5234_2021_03_57.
34
Edmondson, David, Ruoyun Ma, Chien-Lin Yeh, Eric J. Ward, Sandy Snyder, S. Elizabeth Zauber, Frank Rosenthal, and Ulrike Dydak. "Increased GABA levels in manganese-exposed welders correlate with exposure, brain manganese, cognitive function, and motor function." Neurotoxicology and Teratology 49 (May 2015): 121. http://dx.doi.org/10.1016/j.ntt.2015.04.071.
35
Lee, Eun-Young, Michael R. Flynn, Guangwei Du, Mechelle M. Lewis, Rebecca Fry, Amy H. Herring, Eric Van Buren, et al. "T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Level Exposure." Toxicological Sciences 146, no. 2 (May 7, 2015): 281–89. http://dx.doi.org/10.1093/toxsci/kfv088.
36
Foyt, David, Jeffrey P. Johnson, Andrew J. Kirsch, Jeffrey N. Bruce, and Jack J. Wazen. "Dural Closure with Laser Tissue Welding." Otolaryngology–Head and Neck Surgery 115, no. 6 (December 1996): 513–18. http://dx.doi.org/10.1016/s0194-59989670005-0.
Анотація:
This study investigates the use of tissue-soldering techniques to substitute or reinforce traditional suture closure of dural incisions. Fresh human cadaveric dura was incised and subsequently closed by use of three techniques: (1) conventional interrupted suture with 4–0 silk ( n = 25), (2) laser solder reinforced suture closure ( n = 25), and (3) laser solder closure alone ( n = 25). Anastomosis tensile strength and hydrostatic leak pressures were measured. Dural repair was also performed in 15 live Lewis rats. Dural closure was accomplished with 9–0 Prolene sutures ( n = 5), laser-reinforced suture closure ( n = 5), and laser solder closure alone ( n = 5). Histologic examination of the closure immediately after soldering and 2 weeks later was performed. Suture closure alone had the lowest leak pressure, 9.4 ± 1.7 mm Hg, and an intermediate break point, 13.3 ± 2.1 Kgf/cm2. Measurements with laser solder alone revealed a mean leak pressure of 26.2 ± 3.7 mm Hg and a break point of 4.6 ± 1.4 Kgf/cm2. Solder-reinforced suture closure leak pressure measured 64.0 ± 6.7 mm Hg and 21.4 ± 2.4 Kgf/cm2. There was a statistically significant increase in leak pressure and tensile strength in the closures performed with laser weld reinforcement of traditional suture technique ( p = 0.0001). Dural closure with laser tissue welding alone provided an immediate leak-free closure, but with poor tensile strength. Histologic examination of welded dura and underlying brain tissue showed no evidence of thermal injury in four of five animals studied. Laser welding may significantly decrease the incidence of cerebrospinal fluid leak after dural closure. In addition, laser tissue welding also makes dural closure possible where space constraints make traditional suture closure difficult.
37
Rechtman, Elza, Paul Curtin, Lynn C. Onyebeke, Victoria X. Wang, Demetrios M. Papazaharias, Danielle Hazeltine, Erik de Water, et al. "Respirator usage protects brain white matter from welding fume exposure: A pilot magnetic resonance imaging study of welders." NeuroToxicology 78 (May 2020): 202–8. http://dx.doi.org/10.1016/j.neuro.2020.03.008.
38
Majewski, Michal, Karolina Piwko, Michal Ordak, Elzbieta Muszynska, Tadeusz Nasierowski, and Magdalena Bujalska-Zadrozny. "Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations." Journal of Clinical Medicine 13, no. 10 (May 10, 2024): 2823. http://dx.doi.org/10.3390/jcm13102823.
Анотація:
In recent years, a series of articles has been published concerning magnetic resonance imaging (MRI) studies in a group of patients exposed to manganism, specifically factory workers, welders, and individuals with liver diseases, as well as those abusing home-produced ephedrone. Some potential symptoms of manganese toxicity include motor disturbances, neurocognitive problems, sleep disorders, and psychosocial changes. Despite various publications on MRI research in individuals with an elevated risk of manganism, there is a noticeable absence of a comprehensive review in this field. The detection of the accumulation of manganese in the brain through MRI can confirm the diagnosis and guide appropriate treatment. Due to the high cost of determining manganese ion levels in biological material, an additional aim of the manuscript was to identify simple medical laboratory parameters that, when performed concurrently with MRI, could assist in the diagnosis of manganism. Among these types of parameters are the levels of bilirubin, magnesium, liver enzymes, creatinine, hemoglobin, and hematocrit.
39
Torrelli-Diljohn, Alex B., Svetlana Komarova, Vipul Sheth, Benjamin Lin, Paran Goel, Ryan Miller, Robert Welner, and Erwin G. Van Meir. "Abstract 15: Investigating the spectrum of brain tumors associated with Adgrb3 and Tp53 loss in a mouse model of Li-Fraumeni syndrome." Cancer Research 83, no. 7_Supplement (April 4, 2023): 15. http://dx.doi.org/10.1158/1538-7445.am2023-15.
Анотація:
Abstract Adhesion G protein-coupled receptor 3 (ADGRB3), also known as brain specific angiogenesis inhibitor (BAI3) is a member of the ADGRB1-3 subfamily of adhesion transmembrane proteins, which are highly expressed in the brain specifically in cerebellum and hippocampal neurons. ADGRB3 has been shown to play diverse roles under physiological and pathological conditions which include dendritic morphogenesis, synaptic plasticity, synaptogenesis, and myogenesis. Loss of ADGRB3 expression and point mutations in the gene have been observed in sporadic tumors, including brain tumors, but the significance of this observation has not been investigated. Moreover, no mouse models to understand the role of ADGRB3 in brain tumor susceptibility and pathobiology have been developed thus far. Li-Fraumeni syndrome (LFS) is a rare inherited autosomal dominant disorder caused by a germline mutation in one TP53 allele, predisposing patients to the development of a variety of tumors from a pediatric age, including gliomas and medulloblastoma. The secondary molecular alterations that predispose LFS patients to brain tumors are currently unknown. Interestingly, a LFS patient was reported to carry a translocation in ADGRB3 and HGMLL genes. To investigate the molecular mechanisms underlying brain tumor formation in LFS patients and the role of p53 and ADGRB3 in the process, we have generated a LFS mouse model. The mice harbor a germline p53 deleted allele and a second floxed allele. Loss of the second allele is induced in the brain by crossing with mice harboring a Nestin promoter driven Cre recombinase, since Nestin is expressed along the craniospinal axis and in glial precursor cells. We observed that the majority of nestin-Cre p53m/f mice all died between 8 and 10 months of age while nestin-Cre p53m/+ mice did not. About 20% of the mice developed hind leg paralysis and harbored large gliomas, which likely caused their demise. The remainder mice lacked brain tumors, but had other malignancies (sarcomas, etc.) as observed in patients. Remarkably, the addition of Adgrb3 deletion to the genotype led to a dramatic increase (from 20% to 60%??) in the number of brain tumors, including medulloblastoma formation, which are also reported in LFS patients. The Adgrb3-/- p53+/- Nestin-Cre mouse model constitutes a useful tool to understand the tumorigenic landscape caused by the loss of Adgrb3. We are now performing genomic analyses on the excised tumors and derived neurosphere cultures to further study the transformation process and the molecular changes induced by Adgrb3 loss. Citation Format: Alex B. Torrelli-Diljohn, Svetlana Komarova, Vipul Sheth, Benjamin Lin, Paran Goel, Ryan Miller, Robert Welner, Erwin G. Van Meir. Investigating the spectrum of brain tumors associated with Adgrb3 and Tp53 loss in a mouse model of Li-Fraumeni syndrome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 15.
40
Sarkar, Souvarish, Dharmin Rokad, Emir Malovic, Jie Luo, Dilshan S. Harischandra, Huajun Jin, Vellareddy Anantharam, et al. "Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells." Science Signaling 12, no. 563 (January 8, 2019): eaat9900. http://dx.doi.org/10.1126/scisignal.aat9900.
Анотація:
Chronic, sustained inflammation underlies many pathological conditions, including neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate neurotoxicity by increasing inflammation. In this study, we examined whether Mn2+activates the multiprotein NLRP3 inflammasome complex to promote neuroinflammation. Exposing activated mouse microglial cells to Mn2+substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1β (IL-1β). Exposure of mice to Mn2+had similar effects in brain microglial cells. Furthermore, Mn2+impaired mitochondrial ATP generation, basal respiratory rate, and spare capacity in microglial cells. These data suggest that Mn-induced mitochondrial defects drove the inflammasome signal amplification. We found that Mn induced cell-to-cell transfer of the inflammasome adaptor protein ASC in exosomes. Furthermore, primed microglial cells exposed to exosomes from Mn-treated mice released more IL-1β than did cells exposed to exosomes from control-treated animals. We also observed that welders exposed to manganese-containing fumes had plasma exosomes that contained more ASC than did those from a matched control group. Together, these results suggest that the divalent metal manganese acts as a key amplifier of NLRP3 inflammasome signaling and exosomal ASC release.
41
Mohammad Maruf Seizgain. "Investigation of the Effects of Pollution Caused by the Emission of Electromagnetic Waves on Human Health." International Journal for Research in Applied Sciences and Biotechnology 9, no. 2 (April 6, 2022): 227–33. http://dx.doi.org/10.31033/ijrasb.9.2.16.
Анотація:
Electromagnetic force, despite its useful efficiency and achievements, if not controlled and managed, is very dangerous for humans and will have irreversible effects that will remain even after thousands of years. Telecommunication devices such as mobile phones, cordless phones, VHF and SSB wireless and radar .... emit electromagnetic waves that when these waves collide with the living tissue of the body, cause changes in them that They endanger life.
Magnetic and electric fields are generated by power lines, electrical wires, and electrical equipment, and are the invisible power lines that exist around each device, and its power increases with increasing voltage. The electromagnetic field is generated by electrical appliances such as personal computers, televisions, refrigerators, etc., as well as high-voltage power lines. The electromagnetic field disrupts the nervous system and the growth and development and repair of cells, leading to unknown diseases such as cancers, brain tumors and infertility in humans. Therefore, people who are exposed to such fields frequently and for a long time, as well as people working in the electrical and telephone industries, TV repairmen and welders are more vulnerable. Therefore, we must create a suitable environment for work and activity by installing carcinogen control devices in the workplace and identifying the sources of electromagnetic radiation production, observing safety points in the workplace and, if possible, using equipment that has the least amount of electromagnetic waves.
42
Lee, Sohyon, Tobias Weiss, Marcel Bühler, Rebekka Wegmann, Julien Mena, Michel Bihl, Sandra Goetze, et al. "Abstract 5325: Image-based functional precision medicine for repurposing neuroactive drugs in glioblastoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5325. http://dx.doi.org/10.1158/1538-7445.am2022-5325.
Анотація:
Abstract Treatment of glioblastoma multiforme (GBM), the most aggressive form of primary brain cancer, has essentially not advanced over the past few decades. Numerous challenges hinder the successful development of new therapies, including drug delivery across the blood-brain barrier (BBB), the complexity of the tumor microenvironment (TME), and the lack of clinically predictive cancer models. Here, we present the results of an image-based ex vivo drug-testing platform that addresses these therapeutic roadblocks. To demonstrate the clinical utility of our platform, in a retrospective cohort of 14 GBM patients, we show that ex vivo sensitivity to Temozolomide (TMZ, 1st-line GBM chemotherapy), is associated with longer progression free survival (PFS) and overall survival (OS). Next, by screening 150 clinically approved drugs across 27 GBM surgical patient samples, we identify a set of BBB-permeable neuroactive drugs with anti-glioma activity. These neurological drugs display remarkably consistent on-target killing of cancer cells with minimal toxicity to non-malignant TME cells across both primary and recurrent GBM samples. Single-cell transcriptional profiling of GBM patient samples and functional genetics reveals novel glioma-dependencies on neurological drug-target expression. Furthermore, a drug-target network enrichment analysis uncovers an AP1/BTG/TP53 gene signature associated with the anti-glioma activity of neurological drugs. In silico screening of over 1 million compounds for this common gene signature identified additional drug hits that could be validated in patient samples with 90% accuracy. Multiplexed transcriptomics revealed AP-1 transcription factor family activation to be the common underlying feature of neurological drugs with anti-glioma activity. Among the most promising candidate drugs, we identify the atypical antidepressant Vortioxetine as the strongest inducer of this gene signature, and confirm its efficacy in vivo across multiple mouse models. Vortioxetine in combination with Temozolomide or Lomustine further increased median survival in vivo compared to single agents alone. This study thus provides a clinically predictive and personalized drug-testing platform that identifies new treatment opportunities for GBM, warranting further investigation. Citation Format: Sohyon Lee, Tobias Weiss, Marcel Bühler, Rebekka Wegmann, Julien Mena, Michel Bihl, Sandra Goetze, Audrey van Drogen, Elisabeth J. Rushing, Bernd Wollscheid, Michael Weller, Berend Snijder. Image-based functional precision medicine for repurposing neuroactive drugs in glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5325.
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Готцева, Маріана. "A Neurocognitive Perspective on Language Acquisition in Ullman’s DP Model." East European Journal of Psycholinguistics 4, no. 2 (December 28, 2017): 24–33. http://dx.doi.org/10.29038/eejpl.2017.4.2.got.
Анотація:
In the last few decades, the studies in second language acquisition have not answered the question what mechanisms a human’s brain uses to make acquisition of language(s) possible. A neurocognitive model which tries to address SLA from such a perspective was suggested by Ullman (2005; 2015), according to which, “both first and second languages are acquired and processed by well-studied brain systems that are known to subserve particular nonlanguage functions” (Ullman, 2005: 141). The brain systems in question have analogous roles in their language and nonlanguage functions. This article is meant to critically analyse the suggested DP model within the context of neurocognitive studies of L2; and evaluate its contribution to the field of SLA studies.
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Ullman, M.T. & Pieport, E.I. (2005). Specific language impairment is not specific to language: the procedural deficit hypothesis. Cortex, 41, 399-433.
Ullman, M. (2006). Is Broca’s area part of a basal ganglia thalamocortical circuit? In: The Cortex: Integrative Models of Broca’s Area and the Ventral Premotor Cortex. (pp. 480-485). R. Schubotz & C. Fiebach, (Eds.). Milan: Masson.
Ullman, M. (2015) The declarative / procedural model: A neurobiologically motivated theory of first and second language. In: Theories in Second Language Acquisition: An Introduction, (pp. 135-158.) VanPatten, B. and J. Williams, (Eds.). 2nd ed. New York: Routledge.
Ullman, M. and Lovelett, J. (2016). Implications of the declarative / procedural model for improving second language learning: The role of memory enhancement techniques. Second Language Research, Special issue, 1-27.
Zurowski, B., Gostomzyk, J., Gron, G., Weller, R., Schirrmeister, H., Neumeier, B., Spitzer, M., Reske, S.N. & Walter, H. (2002). Dissociating a common working memory network from different neural substrates of phonological and spatial stimulus processing. Neuroimage, 15, 45-57.
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Kushihara, Yoshihiro, Yukari Kobayashi, Koji Nagaoka, and Kazuhiro Kakimi. "647 Possibility of immunotherapy for the glioblastoma patients with O6-methyl-guanine DNA methyltransferase (MGMT) expression or promoter unmethylated." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A676. http://dx.doi.org/10.1136/jitc-2021-sitc2021.647.
Анотація:
BackgroundIt has been widely accepted that O6-methyl-guanine DNA methyltransferase (MGMT) promoter methylation in glioblastoma is associated with a benefit from temozolomide (TMZ) treatment. MGMT is a DNA repair protein that removes the cytotoxic O6-methylguanine (O6MG) DNA lesions generated by TMZ; thereby, MGMT expression is mechanistically linked to TMZ resistance. However, thus far, there is no effective treatment for these patients with MGMT promoter unmethylated. Therefore, a new treatment for GBM patients with MGMT expression is urgently needed.1 2 To this end, we examined the tumor microenvironment in GBM with or without MGMT expression.MethodsBased on The Cancer Genome Atlas (TCGA) primary GBM cohort, the tumor-infiltrating lymphocyte expression level was calculated using the CIBERSORTx algorithms and the single-sample Gene Set Enrichment Analysis (ssGSEA) method. Furthermore, the differential expression gene analysis was conducted and pathway analysis was performed using Ingenuity Pathway Analysis (IPA). The results were validated using the GBM cohort from the Chinese Glioma Genome Atlas (CGGA) database. In addition, tumor-infiltrating lymphocytes (TILs) were isolated from 13 surgically removed primary GBM tumors in our institution. Their responses to autologous tumors were evaluated by IFNγ ELISA.ResultsT cells CD8 score by CIBERSORTx was significantly higher in the MGMT-high tumor. Similarly, ssGSEA scores for activated CD8 T cell, Macrophage, activated B cell, and Type 1 T helper cell were significantly higher in the MGMT-high tumor. Conversely, T cells CD4 naive was significantly higher in the MGMT-low tumor. These results indicate that more immune cell infiltration is associated with MGMT-high tumors. Consistently, tumor-reactive TILs were detected in the MGMT-high tumor. Pathway analysis showed that oxidative phosphorylation (OXPHOS) was highly enriched in the MGMT-high tumor.There were many CD8 T cells and tumor-reactive T cells in the MGMT-high tumors. However, it has been reported that anti-PD-1/PD-L1 monotherapy was not effective in glioblastoma. In this study, we demonstrated that OXPHOS was highly activated in the MGMT-high tumors. Thus, metabolic therapy can be combined with immunotherapy in these MGMT-high tumors to enhance anti-tumor immune responses.ConclusionsAlthough MGMT-high tumors are resistant to TMZ, the existence of immune cell infiltration in the tumor microenvironment of MGMT-high tumors suggest the potential of immunotherapy in these patients.ReferencesStupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJB, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross Jy, Mirimanoff R-O, European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group. Lancet Oncol 2009;10(5):459–66.Wick W, Weller M, van den Bent M, Sanson M, Weiler M, von Deimling A, Plass C, Hegi M, Platten M, Reifenberger G. Nat Rev Neurol 2014;;10(7):372–85.Ethics ApprovalG3545-(26)ConsentWritten informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
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Wacker, Marcel, Gioele Medici, Marissa Dubbelaar, Jens Bauer, Annika Nelde, Luca Regli, Michael Weller, et al. "Abstract 1375: The intra-tumoral spatial heterogeneity of T-cell antigens in glioblastoma: An integrated multi-omics approach." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1375. http://dx.doi.org/10.1158/1538-7445.am2022-1375.
Анотація:
Abstract Glioblastoma is the most common primary malignant neoplasm of the central nervous system in adults. Current treatment options comprise maximal surgical resection followed by radiation and/or chemotherapy with temozolomide. However, these procedures are unable to eliminate all tumor cells, which in turn lead to disease recurrence accounting for the poor prognosis. Glioblastoma is a highly infiltrative tumor in which recurrence originates from the unresectable peritumoral infiltration zone. Thus, novel treatment options specifically targeting the tumor cells in the infiltration zone are needed to prevent relapse and enable long-lasting remission. In this work, we performed multi-omics spatial analysis of the necrotic center (NEC), the gadolinium contrast-enhanced region (T1), and the infiltration zone (INF) to assess immunological relevant aspects of tumor heterogeneity. By integrating mass spectrometry-based immunopeptidome analysis with next generation sequencing methods (whole exome and RNA sequencing, DNA methylation), we aimed to identify the intra-tumoral regional heterogeneity of T cell antigens with a special focus on the peritumoral infiltration zone. For multi-omics analysis, HLA peptides and genetic material from 15 glioblastoma patients were extracted and analyzed from the three zones NEC, T1, INF and for four patients additionally from adjacent benign (BEN) brain tissue. A total of 24,699 unique HLA class I and 17,394 HLA class II peptides were identified. Comparative profiling of peptides from our study and a benign tissue database (in-house (n=429) combined with HLA ligand atlas (https://hla-ligand-atlas.org)) revealed that 6% (970/15,579), 5% (829/16,442) and 5% (725/13,891) of HLA class I peptides were exclusively presented in the INF, T1 and NEC zone, respectively. 6% (394/7,150), 7% (589/8,736) and 13% (1,725/12,908) of HLA class II peptides showed exclusive representation in the INF, T1 and NEC zone, respectively. Importantly, due to the spatial analysis of the immunopeptidome, we revealed 970 HLA class I and 394 HLA class II peptides exclusively presented in the INF zone. Interestingly, one INF-associated HLA class I peptide, which showed frequent presentation in 36% of glioblastoma immunopeptidomes, is derived from the brain and acute leukemia cytoplasmic protein (BAALC), a highly expressed cell cycle inducer (via MEK kinase-1) in several cancers, including glioblastoma. Integrated RNA/DNA sequencing enabled a greater understanding of spatial tumor antigen presentation and lead to the identification of INF-specific neoepitopes derived from tumor-specific mutations. In summary, we identified the intra-tumoral regional heterogeneity of tumor antigens, which could be used in the future for specific immunotherapy approaches targeting the infiltration zone of glioblastoma. Citation Format: Marcel Wacker, Gioele Medici, Marissa Dubbelaar, Jens Bauer, Annika Nelde, Luca Regli, Michael Weller, Helmut R. Salih, Hans-Georg Rammensee, Marian C. Neidert, Juliane S. Walz. The intra-tumoral spatial heterogeneity of T-cell antigens in glioblastoma: An integrated multi-omics approach [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1375.
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Geurts, Marjolein, Dorothee Gramatzki, Sara Merler, Matteo Duca, Fabio Girardi, Ugur T. Sener, Domenico Roberti, et al. "Abstract LB_A12: Initial results from 2 Phase I studies of NMS-03305293, a selective PARP1 inhibitor." Molecular Cancer Therapeutics 22, no. 12_Supplement (December 1, 2023): LB_A12. http://dx.doi.org/10.1158/1535-7163.targ-23-lb_a12.
Анотація:
Abstract Background PARP-1 has a well-established role in DNA repair. PARP-1 selective inhibitors are a new subclass of PARPi that offer potential for improved tolerability. NMS-03305293 (NMS-293) is an oral, brain-penetrant PARP-1 selective inhibitor with strong antitumor activity in BRCA mutated preclinical models. Furthermore, NMS-293 is synergistic with temozolomide (TMZ) in glioblastoma mouse models. Methods Two phase I/I-II dose-escalation/expansion studies assessed safety, tolerability, and preliminary antitumor activity of NMS-293. Both are actively recruiting. In PARPA-293-001 (NCT04182516), NMS-293 was administered orally, ranging from 20 mg (QD) to 160 mg (BID) for 21 or 28 days on 28-day cycle in adult patients with advanced/metastatic, relapsed/refractory solid tumors who have exhausted standard treatment options. In PARPA-293-002 (NCT04910022), NMS-293 was administered in a range of doses orally, QD or BID on days 1-7 plus TMZ 150mg/m2 QD on days 1-5 in repeated 28-day cycle in adult patients with recurrent diffuse gliomas. Tumor responses were measured by investigator-assessed RANO criteria. Results The unpooled safety database at the data-cut-off (02-AUG-23), includes 45 patients in PARPA-001 and 21 patients in PARPA-002. PARPA-001 showed an MTD of 100 mg BID for 28 days on a 28-day cycle, a dose with meaningful PK relative to preclinical activity. PARPA-002 dose finding is ongoing with no DLTs as of cutoff date. The most frequent (≥10%) any-grade treatment related adverse events (TRAEs) in PARPA-001 were reversible QTcF prolongation, nausea, asthenia, decreased appetite and vomiting, mainly mild/moderate. In PARPA-002, with discontinuous NMS-293 plus TMZ, no G≥3 TRAEs were reported. The most frequent (≥10%) any-grade TRAEs were: nausea, fatigue, vomiting, decreased appetite, and platelet count decreased, mainly G1 adverse events. Overall, no dose-dependent trends of myelosuppression have been observed. 14 recurrent glioma patients across dose levels in PARPA-002 were evaluable for tumor response. A patient with glioblastoma had confirmed partial response (PR) with duration 7.6+ weeks, remaining on treatment at cutoff date. A patient with grade 3 IDH-mutant astrocytoma had unconfirmed PR with ongoing tumor shrinkage at 16.1+ weeks. A patient with glioblastoma had complete radiological disappearance of enhancing non-target lesions, remaining on treatment at cutoff date. NMS-293 PK profiles showed an increase in exposure with the dose with approximately 5 to 13 hours half-life. Conclusion NMS-293, a PARP-1 selective, brain penetrant inhibitor was well tolerated in phase I clinical trials with no dose dependent trends of myelosuppression. Furthermore, NMS-293 showed encouraging clinical activity in combination with TMZ in difficult-to-treat recurrent glioma patients. Citation Format: Marjolein Geurts, Dorothee Gramatzki, Sara Merler, Matteo Duca, Fabio Girardi, Ugur T. Sener, Domenico Roberti, Grazia Saturno, Patrizia Crivori, Alessia Montagnoli, Lisa Mahnke, Siqing Fu, Paola Gaviani, Kurt A. Jaeckle, Jian Zhang, Yehui Shi, Valentina Guarneri, Michael Weller, Sani H. Kizilbash, Martin J. van den Bent, Michele Milella, Silvia Damian. Initial results from 2 Phase I studies of NMS-03305293, a selective PARP1 inhibitor [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr LB_A12.
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Tankus, Ariel, and Itzhak Fried. "Visuomotor Coordination and Motor Representation by Human Temporal Lobe Neurons." Journal of Cognitive Neuroscience 24, no. 3 (March 2012): 600–610. http://dx.doi.org/10.1162/jocn_a_00160.
Анотація:
The division of cortical visual processing into distinct dorsal and ventral streams is a key concept in primate neuroscience [Goodale, M. A., & Milner, A. D. Separate visual pathways for perception and action. Trends in Neurosciences, 15, 20–25, 1992; Steele, G., Weller, R., & Cusick, C. Cortical connections of the caudal subdivision of the dorsolateral area (V4) in monkeys. Journal of Comparative Neurology, 306, 495–520, 1991]. The ventral stream is usually characterized as a “What” pathway, whereas the dorsal stream is implied in mediating spatial perception (“Where”) and visually guided actions (“How”). A subpathway emerging from the dorsal stream and projecting to the medial-temporal lobe has been identified [Kravitz, D. J., Saleem, K. S., Baker, C. I., & Mishkin, M. A new neural framework for visuospatial processing. Nature Reviews Neuroscience, 12, 217–230, 2011; Cavada, C., & Goldman-Raiuc, P. S. Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory cortico-cortical connections. Journal of Comparative Neurology, 287, 393–421, 1989]. The current article studies the coordination of visual information typically associated with the dorsal stream (“Where”), with planned movements, focusing on the temporal lobe. We recorded extracellular activity from 565 cells in the human medial-temporal and frontal lobes while 13 patients performed cued hand movements with visual feedback (visuomotor task), without feedback (motor task), or observed visual feedback without motor movement (visual-only task). We discovered two different neural populations in the human medial-temporal lobe. One consists of motor-like neurons representing hand position, speed or acceleration during the motor task but not during the visuomotor or visual tasks. The other is specific to the parahippocampal gyrus (an area known to process visual motion [Gur, M., & Snodderly, D. M. Direction selectivity in V1 of alert monkeys: Evidence for parallel pathways for motion processing. Journal of Physiology, 585, 383–400, 2007; Sato, N., & Nakamura, K. Visual response properties of neurons in the parahippocampal cortex of monkeys. Journal of Neurophysiology, 90, 876–886, 2003]) and encodes speed, acceleration, or direction of hand movements, but only during the visuomotor task: neither during visual-only nor during motor tasks. These findings suggest a functional basis for the anatomical subpathway between the dorsal stream and the medial-temporal lobe. Similar to the recent expansion of the motor control process into the sensory cortex [Matyas, F., Sreenivasan, V., Marbach, F., Wacongne, C., Barsy, B., Mateo, C., et al. Motor control by sensory cortex. Science, 330, 1240–1243, 2010], our findings render the human medial-temporal lobe an important junction in the process of planning and execution of motor acts whether internally or externally (visually) driven. Thus, the medial-temporal lobe might serve as an integration node between the two processing streams. Our findings thus shed new light on the brain mechanisms underlying visuomotor coordination which is a crucial capacity for everyday survival, whether it is identifying and picking up food, sliding a key into a lock, driving a vehicle, or escaping a predator.
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Zilberberg, Jenny, Amelia Zellander, Kenneth Kirby, Christopher Uhl, Christopher Cultrara, Charles Scott, David Andrews, and Mark Exley. "218 Autologous glioblastoma tumor cells and an antisense oligonucleotide against insulin-like growth factor type 1 receptor protect against tumor challenge and generate T cell anti-tumor responses." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A231. http://dx.doi.org/10.1136/jitc-2021-sitc2021.218.
Анотація:
BackgroundIGV-001 is a novel immunotherapy that combines irradiated, patient-derived glioblastoma tumor cells and an antisense oligonucleotide against insulin-like growth factor type 1 receptor (IMV-001) in biodiffusion chambers (0.1-micron pore size). We recently evaluated IGV-001 in patients with newly diagnosed glioblastoma.1 In a subgroup of IGV-001-treated, Stupp-eligible patients2 with methylated O6-methylguanine–DNA methyl-transferase (MGMT) promoter, median progression free survival was 38.4 months1 compared with 8.3 months in historical standard-of-care-treated patients (p=0.0008).2 We utilized the GL261-Luciferase (-Luc) glioblastoma orthotopic murine model and conducted in vitro immunological assays using patient-derived GBM tumor cells and matched peripheral blood mononuclear cells (PBMC) to unravel the potential mechanisms associated with the activity of IGV-001.MethodsBiodiffusion chambers containing phosphate-buffered saline (PBS) alone or IGV-001 prepared with 1x106 GL261-Luc cells were implanted in the flanks of C57BL/6 albino mice and explanted 48 hours later, as per the clinical protocol. GL261-Luc intracranial tumor challenge was conducted 28 days after chamber implantation. Mice were monitored for survival and tumor growth, as determine by bioluminescence intensity (BLI). For in vitro experiments, IGV-001 prepared with patient tumor cells were co-cultured with patient-derived PBMC to evaluate activated and memory T cell subsets and responses. To elucidate the immunostimulatory underpinnings of IGV-001, ATP release assay was conducted as a surrogate measure of immunogenic cell death.Results59% of IGV-001 treated mice were alive and continued to gain weight at the termination of the study, 58 days post–intracranial tumor challenge. In comparison, there were no survivors in the PBS group by day 24 (p<0.001). Fluorospot assays demonstrated enhanced T cell IFN-gamma responses to tumor cell antigens. In IGV-001 treated mice, serum IL-6 was positively correlated with BLI, meaning that treated mice with lower BLI signal had less circulating IL-6 (p<0.01). Fluorospot assays demonstrated enhanced T cell IFN-gamma responses to tumor cell antigens. Tumor co-culture studies showed elevated percentage of activated CD4 and CD8 T cells as well as increased central and effector memory phenotypes in both T cell subsets compared to IMV-001-treated PBMC controls. Lastly, tumor cells treated with IMV-001 released significantly more (p<0.01) ATP than untreated or sense oligonucleotide-treated controls.ConclusionsThese data support the antitumor activity of IGV-001 in newly diagnosed glioblastoma, as evidenced in the phase 1 study. Th1 anti-tumor T cell activity was demonstrated. The ATP results suggest a possible immunogenic conversion by which IGV-001 stimulates the immune system and suppresses tumor growth, which can be quantified via circulating IL-6.ReferencesAndrews DW, Judy KD, Scott CB, Garcia S, Harshyne LA, Kenyon L, Talekar K, Flanders A, Atsina KB, Kim L, Martinez N, Shi W, Werner-Wasik M, Liu H, Prosniak M, Curtis M, Kean R, Ye DY, Bongiorno E, Sauma S, Exley MA, Pigott K, Hooper DC. Phase Ib clinical trial of IGV-001 for patients with newly diagnosed glioblastoma. Clin Cancer Res 2021 April 1;27(7):1912–1922. doi: 10.1158/1078-0432.CCR-20-3805. Epub 2021 Jan 26. PMID: 33500356.Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005 March 10;352(10):987–96. doi: 10.1056/NEJMoa043330. PMID: 15758009.Ethics ApprovalEthical consent was obtained for all human biospecimens with the appropriate IRB approval.ConsentInformed consent was obtained for all human biospecimens with the appropriate IRB approval.
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Miller, Jeffrey, Frank Cichocki, Jianfang Ning, Ryan Bjordahl, Zachary Davis, Katie Tuininga, Hongbo Wang, et al. "155 iPSC-derived NK cells mediate robust anti-tumor activity against glioblastoma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A169. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0155.
Анотація:
BackgroundGliomas represent the most common brain tumors within the central nervous system, with glioblastoma being the most aggressive type.1 Conventional treatment combines several approaches including surgery, chemotherapy, and radiation.2 However, the prognosis for glioblastoma remains unfavorable, with only 5% of patients surviving more than 5 years post-diagnosis.3 Thus, new treatment approaches are urgently needed. Natural killer (NK) cells directly lyse malignantly transformed or virally infected cells and secrete inflammatory cytokines that polarize cytotoxic immunity. Allogeneic NK cell adoptive transfer has shown clinical benefit in patients with advanced cancer.4–7 However, limitations of this approach include relatively low numbers of donor NK cells that can be isolated during an apheresis and variability in the quality of NK cells between donors. To overcome these limitations, we have developed a GMP manufacturing strategy to mass produce NK cells from induced pluripotent stem cells (iPSCs) as an approach to off-the-shelf cancer immunotherapy. We refer to these cells as ‘iNK’ (iPSC-derived NK) cells. Here, we provide preclinical data demonstrating the efficacy of iNK cells for immunotherapy against glioblastoma.Abstract 155 Figure 1Engineered iNK cells exhibit highly effective antitumor function in a xenogeneic model of glioblastoma. (A) Schematic of the experimental design to test iNK cell function against glioblastoma in vivo. (B) Kaplan Meier plots showing survival for groups of mice that received either vehicle alone or iNK cells after tumor engraftment (n=5 mice/group)MethodsWe generated iNK cells using previously published methods.8–10 iNK cells were used as effectors against an array of patient-derived glioblastoma lines in 2-dimensional live imaging IncuCyte assays where iNK cell-mediated killing was observed over the course of 48 hours. To investigate iNK cell infiltration and cytotoxicity in a more physiological context that accounts for the 3-dimensional architecture of the tumor, we also performed live imaging IncuCyte assays using iNK cells as effectors against glioblastoma spheroids. To test the anti-tumor function of iNK cells in vivo, we implanted patient-derived glioblastoma cells into mice via intracranial injection. Seven days later, 5 mice received intratumoral injections of iNK cells, and 5 mice received vehicle alone (as a control; figure 1A). All mice were monitored for weight and survival over 100 days.Results iNK cells exhibited strong and sustained cytotoxicity against 6 primary patient-derived mesenchymal glioblastoma lines in 2-dimensional IncuCyte assays and complete infiltration and destruction of glioblastoma spheroids in 3-dimensional IncuCyte assays. In xenogeneic adoptive transfer experiments, all mice receiving intratumoral injections of iNK cells survived out to day 100, while all mice in the vehicle group became moribund and had to be sacrificed by day 60 (figure 1B).ConclusionsiNK cells are highly cytotoxic against glioblastoma cells, and our preclinical in vivo data provides proof-of-concept for future clinical trials.Ethics ApprovalThis project has been approved by the University of Minnesota IACUC. Approval ID: 1812-36595AReferencesLouis D N, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W K, Ohgaki H, Wiestler O D, Kleihues P, Ellison D W. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016;131:803–820.Stupp R, Mason W P, van den Bent M J, Weller M, Fisher B, Taphoorn M J B, Belanger K, Brandes A A, Marosi C, Bogdahn U, Curschmann J, Janzer R C, Ludwin S K, Gorlia T, Allgeier A, Lacombe D, Cairncross J G, Eisenhauer E, Mirimanoff R O, European Organization for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–996.Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholz-Sloan JS, Villano JL. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev 2017;23:1985–1996.Miller J S, Soignier Y, Panoskaltsis-Mortari A, McNearney S A, Yun G H, Fautsch S K, McKenna D, Le C, Defor T E, Burns L J, Orchard P J, Blazar B R, Wagner J E, Slungaard A, Weisdorf D J, Okazaki J, McGlave P B. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005;105:3051–3057.Bachanova V, Cooley S, Defor T E, Verneris M R, Zhang B, McKenna D H, Curtsinger J, Panoskaltsis-Mortari A, Lewis D, Hippen K, McGlave P, Weisdorf D J, Blazar B R, Miller J S. Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood 2014;123:3855.Ciurea S O, Schafer J R, Bassett R, Denman C J, Cao K, Willis D, Rondon G, Chen J, Soebbing D, Kaur I, Gulbis A, Ahmed S, Rezvani K, Scpall E J, Lee D A, Champlin R E. Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplant. Blood 2017;130:1857–1868.Romee R, Rosario M, Berrien-Elliott M M, Wagner J A, Jewell B A, Schappe T, Leong J W, Abdel-Latif S, Schneider S E, Willey S, Neal C C, Yu L, Oh T, Lee S, Mulder A, Cooper M A, Fehniger T A. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukiemia. Sci Transl Med 2016:8;375ra123.Valamehr B, Abujarour R, Robinson M, Le T, Robbins D, Shoemaker D, Flynn P. A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. Sci Rep 2012:2;213.Valamehr B, Robinson M, Abujarour R, Rezner B, Vranceanu F, Le T, Medcalf A, Lee T T, Fitch M, Robbins D, Flynn P. Platform for induction and maintenance of transgene-free hiPSCs resembling ground state pluripotent stem cells. Stem Cell Reports 2014;2:366–381.Zhu H, Blum R H, Bjordahl R, Gaidarova S, Rogers P, Lee T T, Abujarour R, Bonello G B, Wu J, Tsai P-F, Miller J S, Walcheck B, Valamehr B, Kaufman D S. Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor immunity. Blood 2020;135:399–410.
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Susanti, Devany Arfilia, and Edy Yusuf Agung Gunanto. "Faktor yang Mempengaruhi Intention to Recommend Produk Kosmetik Halal (Studi Kasus di Kota Tangerang Selatan)." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 4 (July 31, 2022): 543–58. http://dx.doi.org/10.20473/vol9iss20224pp543-558.
Анотація:
ABSTRAK Sektor kosmetik halal saat ini dianggap sebagai sektor dengan potensi tertinggi secara global. Berkembangnya tren penggunaan kosmetik halal dipengaruhi oleh tren hijrah dan gaya hidup umat Muslim yang sadar dengan urgensi penggunaan produk halal. Ketersediaan produk kosmetik halal yang beragam di pasaran mendorong konsumen lebih diskriminatif dalam pemilihan merek kosmetiknya. Perusahaan perlu merumuskan strategi pemasaran yang tepat agar produknya dapat bertahan dan bersaing dengan kompetitor, salah satunya melalui rekomendasi atas suatu produk tertentu. Penelitian ini bertujuan untuk menganalisis faktor yang mempengaruhi intensi konsumen untuk merekomendasikan produk kosmetik halal. Metode yang digunakan dalam penelitian yaitu Structural Equation Modelling (SEM) dengan alat analisis SmartPLS 3. Data primer diperoleh melalui kuesioner dengan 180 sampel masyarakat di Kota Tangerang Selatan. Hasil penelitian mengungkapkan bahwa customer satisfaction, product quality, dan customer experience berpengaruh secara positif dan signifikan terhadap intention to recommend produk kosmetik halal, sedangkan trust tidak berpengaruh secara signifikan terhadap intention to recommend produk kosmetik halal. Kata kunci: Kosmetik halal, customer satisfaction, trust, product quality, customer experience, intention to recommend. ABSTRACT The halal cosmetics sector is currently considered the sector with the highest potential in the world. The growing trend of using halal cosmetics is influenced by the migration trend and lifestyle of Muslims who are aware of the importance of using halal products. The presence of various halal cosmetic products on the market encourages consumers to be more selective in their choice of cosmetic brands. Companies need to formulate the right marketing strategy in order for their products to survive and compete with competitors, one of which is product-specific recommendations. This study aims to analyze the factors that influence consumers' intentions to recommend halal beauty products. This study used Structural Equation Modeling (SEM) with the SmartPLS 3 analysis tool. Primary data was obtained from a survey of 180 samples of people in the city of South Tangerang. The results of the study show that customer satisfaction, product quality, and customer experience have a positive and significant impact on the intention to recommend halal beauty products, while trust does not have a significant effect on the intention to recommend halal beauty products. Keywords: Halal cosmetics, customer satisfaction, trust, product quality, customer experience, intention to recommend. DAFTAR PUSTAKA Abu Bakar, E., Rosslee, N. N., Mastura, A., Ariff, M., Othman, M., & Hashim, P. (2017). 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