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Stewart, Devin J. "Kitāb al-Waṣāyā (The Book of Legacies) and the Works of Mathematician Abū Kāmil Shujāʿ b. Aslam". Journal of Abbasid Studies 3, № 2 (9 листопада 2016): 129–66. http://dx.doi.org/10.1163/22142371-12340025.
Повний текст джерелаАнотація:
Abū Kāmil Shujāʿ b. Aslam al-Miṣrī (fl. 3rd/9th c.) was an important medieval algebraist and successor of Muḥammad b. Mūsā l-Khwārizmī (d. ca. 235/850). His major work on algebra, Kitāb fī l-Jabr wa-l-muqābala, commented on and expanded the work of al-Khwārizmī. Knowledge of Abū Kāmil’s contribution to the history of mathematics is based on three categories of sources: the extant manuscripts of his works, bibliographies such as the Fihrist of Ibn al-Nadīm (d. 380/990) and Kashf al-ẓunūn of Ḥājjī Khalīfa (d. 1067/1657), and commentaries on and quotations from his works by later mathematicians. This study endeavors to clear up some uncertainties regarding Abū Kāmil’s bibliography, correcting views expressed in the history of secondary scholarship on Abū Kāmil and focusing on his work Kitāb al-Waṣāyā (The Book of Legacies).
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Boudignon, Christian. "Logique aristotélicienne et kalām ʿalā-l-naṣārā : la réponse à Abū Qurra dans le Muġnī de ʿAbd al-Ğabbār". Arabica 58, № 6 (2011): 519–44. http://dx.doi.org/10.1163/157005811x561550.
Повний текст джерелаАнотація:
Abstract Ending his refutation of Christian theology in al-Muġnī fī abwāb al-tawḥīd wa-l-ʿadl (written between 361-380/971-990), ʿAbd al-Ğabbār assumes the reasons given by an unknown author against Abū Qurra, bishop of Ḥarrān (d. ca 210/825). According to Abū Qurra, God needs an eternal Son in order to have an equal to “dominate”, lest he should be deprived of honor and sovereignty. The unknown author laughs at this need of a subject God and Son, and argues throughout against this thought out of the Aristotelian category of “relative”. ʿAbd al-Ğabbār’s text, compared to Abū Qurra’s two treatises on this theme, shows up that it may be based on a lost Arabic treatise (known today through its Greek translation). The unknown author might be the theologian al-Murdār (m. 226/840), whose treatise Against Abū Qurra is recorded by al-Nadīm.
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Stewart, Devin J. "Editing the Fihrist of Ibn al-Nadīm." Journal of Abbasid Studies 1, no. 2 (October 1, 2014): 159–205. http://dx.doi.org/10.1163/22142371-12340010.
Повний текст джерелаАнотація:
Arabic and Islamic studies, whether of the Abbasid or later periods, suffer from the lack of reliable editions of fundamental resources such as al-Ṭabarī’sTārīkh al-rusul wa-l-mulūk, al-Masʿūdī’sMurūj al-dhahab wa-maʿādin al-jawhar, Abū l-Faraj al-Iṣbahānī’sKitāb al-Aghānī, and others, despite a long history of scholarly interest in, and intensive use of these particular texts. The appearance in 2009 of the new edition of theFihristof Ibn al-Nadīm (d. 380/990) by Ayman Fuʾād Sayyid (hereafterafs) provides an opportunity to reflect on this general problem by considering the historical progress made in the editing and contextualization of this text that is central to the understanding of Abbasid history and letters and to nearly all the intellectual traditions that had arisen in the Islamic world by the fourth/tenth century. As will become clear, the complex history of scholarship on theFihristis an object lesson on the problem of failing adequately to take into account the work of earlier editors and scholars, made particularly difficult in this case by linguistic barriers and limited access to widely scattered publications. The following remarks attempt to reviewafs’s edition of theFihrist, to compare the views ofafs, the Russian scholar Valeriy V. Polosin, and others regarding the context and background of theFihrist, and to give an overview of the current state of knowledge about Ibn al-Nadīm and theFihrist. It will be argued that, beyond reliably publishing the contents of the earliest extant manuscript of theFihrist, substantial emendations to the text are required to produce a reliable edition of the work. An evaluation ofafs’s emendations to the text is followed by a number of additional proposed emendations.
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Patirnac, Iulian, Razvan George Ripeanu, and Eugen Laudacescu. "The Influence of the AWJM Working Parameters on Manufactured Surfaces Microgeometry." MATEC Web of Conferences 318 (2020): 01011. http://dx.doi.org/10.1051/matecconf/202031801011.
Повний текст джерелаАнотація:
The aim of this paper is to make a research in order to analyze the modification of the microgeometry parameters of AWJ machined surfaces for a ductile material used in oilfield and petrochemical equipment. Experimental research was performed on waterjet cutting machine model YCWJ-380-1520 using pre-establish working conditions. The SURTRONIC 3+ device was used in order to measure the microgeometry characteristics of the machined surfaces. Experimental tests were performed regarding some values for: material thickness, working feed-rate and standoff distance. The obtained outcomes highlighted that there are three zones on cutting surfaces for thick material and only two zones for thin materials. There are a lot of profile parameters provided by the software and there were taken into account only the average roughness (Ra) and average waviness (Wa). For each of those two parameters were accomplished graphical representation for every working parameters in order to establish an analytical dependence between them. The outcomes which were obtained are polynomial four order equations of average roughness and waviness according to standoff distance. The analytical relations obtained give us the possibility to estimate the average roughness of the surfaces related to thickness, feed-rate and standoff distance.
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Patarnello, Claudia. "El Occidente islámico en la obra de al-Muqaddasī." El Futuro del Pasado 11 (September 9, 2020): 17–30. http://dx.doi.org/10.14516/fdp.2020.011.001.
Повний текст джерелаАнотація:
En el presente artículo se hará una aproximación a la obra geográfica de al-Muqaddasī (380/990), Kitāb aḥsan al-taqāsīm fī maʿrifat al-aqālīm (La mejor división para el conocimiento de las provincias). Su concepción geográfica y su metodología sistemática lo convierten en uno de los mejores representantes de la literatura geográfica del siglo X. Aunque su obra abarca la geografía del imperio controlado por los musulmanes (mamlaka), el trabajo se centrará exclusivamente en Occidente islámico, del que al-Muqaddasī ofrece una visión muy interesante, tanto por su origen oriental como por las fuentes utilizadas (no viajó a al-Andalus y es poco probable que lo hiciera al Mágreb, lo cual no resta objetividad a su trabajo). Como cultivador del género de al-masālik wa-l-mamālik (Los caminos y los reinos), se ocupó de los topónimos y rutas principales occidentales, los cuales detalla exhaustivamente en su obra. Pero su labor de especialista fue más allá, interesándose por aspectos propios de la geografía física y humana. Por esta razón, en su obra ofrece muchos detalles sobre las poblaciones de las zonas descritas (costumbres, tipos de comida, vestimenta, religión etc...), aportando un testimonio único y preciso de gran valor para todos los interesados el Occidente islámico medieval.
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Afzali, Meena, and Joshua Siaw Boateng. "Composite Fish Collagen-Hyaluronate Based Lyophilized Scaffolds Modified with Sodium Alginate for Potential Treatment of Chronic Wounds." Polymers 14, no. 8 (April 11, 2022): 1550. http://dx.doi.org/10.3390/polym14081550.
Повний текст джерелаАнотація:
Chronic wounds are characterized by both decreased collagen deposition and increased collagen breakdown. It is reasonable to hypothesize that exogenous collagen can potentially promote wound healing by reducing degradation enzymes in the wound environment and disrupting the cycle of chronicity. Therefore, this study aimed to develop an optimal combination of fish collagen (FCOL), sodium alginate (SA), and hyaluronic acid (HA) loaded with bovine serum albumin (BSA) as a model protein fabricated as lyophilized scaffolds. The effects of sodium alginate (SA#) with higher mannuronic acid (M) were compared to sodium alginate (SA*) with higher guluronic acid (G). The SA* with higher G resulted in elegant scaffolds with hardness ranging from 3.74 N–4.29 N that were able to withstand the external force due to the glycosidic bonds in guluronic acid. Furthermore, the high G content also had a significant effect on the pore size, pore shape, and porosity. The water absorption (WA) ranged from 380–1382 (%) and equilibrium water content (EWC) 79–94 (%) after 24 h incubation at 37 °C. The SA* did not affect the water vapor transmission rate (WVTR) but incorporating BSA significantly increased the WVTR making these wound dressing scaffolds capable of absorbing about 50% exudate from a heavily exuding chronic wound. The protein released from the composite systems was best explained by the Korsmeyer–Peppas model with regression R2 values ranging from 0.896 to 0.971 and slope or n < 0.5 indicating that the BSA release mechanism was governed by quasi-Fickian diffusion. Cell viability assay showed that the scaffolds did not inhibit the proliferation of human dermal fibroblasts and human epidermal keratinocytes, and are therefore biocompatible. In vitro blood analysis using human whole blood confirmed that the BSA-loaded SA*:FCOL:HA scaffolds reduced the blood clotting index (BCI) by up to 20% compared to a commercially available sponge for chronic wounds. These features confirm that SA*:FCOL:HA scaffolds could be applied as a multifunctional wound dressing.
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Mack, Michael J. "50th Anniversary Landmark Commentary on Tribble CG, Killinger WA Jr, Harman PK, Crosby IK, Nolan SP, Kron IL. Anterolateral thoracotomy as an alternative to repeat median sternotomy for replacement of the mitral valve. Ann Thorac Surg 1987;43:380–2." Annals of Thoracic Surgery 100, no. 6 (December 2015): 1988–89. http://dx.doi.org/10.1016/j.athoracsur.2015.10.061.
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Ateya, Nester, Eric Walela Wamalwa, and Stanley Adika Kevogo. "Mikabala Tofauti ya Waandishi wa Vitabu vya Kiada kuhusu Kipengele cha Mtindo wa Uandishi Insha za Kiswahili Nchini Kenya." East African Journal of Swahili Studies 7, no. 1 (March 6, 2024): 114–23. http://dx.doi.org/10.37284/jammk.7.1.1803.
Повний текст джерелаАнотація:
Makala haya yanabainisha mikabala ya waandishi wa vitabu vya kiada katika ufundishaji na ujifundishaji wa mtindo wa insha za Kiswahili kwa shule za upili nchini Kenya. Mikabala tofauti ya waandishi aghalabu huwa chanzo cha utata miongoni mwa walimu na wanafunzi na hivyo kuathiri matokeo ya mtihani wa kitaifa. Uchunguzi huu umekitwa kwa mihimili ya Nadharia ya Mtindo iliyoasisiwa na Louis Tonko Milic. Nadharia hii inashikilia kuwa mtindo hutegemea mtu binafsi. Utafiti huu ulitumia muundo wa kimaelezo, mkabala wa kithamano. Idadi lengwa ya utafiti ni walimu wa somo la Kiswahili 73, wanafunzi 2,000 na vitabu vya kiada 7 vya shule za upili. Kwa hivyo, usampulishaji wa kimakusudi ulitumiwa kuteua walimu 22, wanafunzi 320 na vitabu vya kiada 6. Mbinu za ukusanyaji wa data zilizotumika ni uchanganuzi wa yaliyomo, mahojiano na hojaji. Data ilichanganuliwa kwa kutumia asilimia, majedwali na kuwasilishwa kiufafanuzi. Matokeo ya uchunguzi yanaonesha kwamba, matumizi ya vitabu vya kiada tofauti tofauti yanazua mikabala tofauti katika ufundishaji na ujifundishaji wa mtindo wa insha. Hali hii inatokana na waandishi wa vitabu kiada kuwa na mikabala tofauti kuhusu mtindo wa insha za Kiswahili. Matokeo ya uchunguzi huu ni muhimu kwa walimu na wanafunzi wa Kiswahili katika shule za upili, viwango vingine vya elimu na wakuza mitaala pamoja na waandishi wa vitabu vya kiada. Wizara ya Elimu pamoja na vyuo vya walimu kupitia warsha na maarifa zaidi ya yale ya vitabu vya kiada, watafaidi mikakati ya kuimarisha ufundishaji na ujifundishaji wa somo la insha
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Partington, M., K. Aurisch, W. Clark, I. Newlands, S. Phelps, P. Senycia, P. Siffleet, and T. Walker. "THE HYDROCARBON POTENTIAL OF EXPLORATION PERMITS WA-299-P AND WA-300-P, CARNARVON BASIN: A CASE STUDY." APPEA Journal 43, no. 1 (2003): 339. http://dx.doi.org/10.1071/aj02018.
Повний текст джерелаАнотація:
Exploration permits WA-299-P and WA-300-P lie west of the North West Cape in a frontier part of the Carnarvon Basin where the largely Mesozoic Exmouth Sub-basin abuts against shallow Palaeozoic strata of the Gascoyne Platform. The only exploration well, within the permits, Pendock–1, penetrated a thin Valanginian Birdrong Sandstone unconformably overlying Carboniferous to Silurian units, so the Mesozoic hydrocarbon potential of the area is effectively untested.The structure of the area comprises a complex mosaic of NNE–SSW trending Early Palaeozoic extensional, listric growth faults, dissected by NW–SE trending Permian extension relay zones. Subsequent phases of Callovian– Oxfordian and Valanginian uplift, together with Late Cretaceous and Miocene inversion along the main fault zone, further complicate the structure. Several seismic events, some of which correlate with magnetic anomalies, are discordant with the local stratigraphy indicating a probable igneous origin.The primary targets are the Birdrong Sandstone and underlying Wogatti Formation, both of which host onshore oil accumulations at Rough Range and Parrot Hill–1. The retrogradational clastic shoreline facies of the Birdrong Sandstone is well known along the eastern edge of the Dampier–Barrow–Exmouth Sub-basins. The Wogatti Formation was deposited as a more restricted alluvial/ fluvial sheet sand facies, so far identified only in the onshore Cape Range area. Where the Jurassic is preserved, fluvial/alluvial channel sand facies of the Middle Jurassic Learmonth Formation, known onshore at Sandy Point–1, and Callovian nearshore sands, as observed in Unknown Hill–l, are expected to be important secondary targets.The most promising play types within the Southern Carnarvon Basin are dip and fault-dip closures at Birdrong/Wogatti level associated with Late Cretaceous reactivation of the main NE–SW listric faults, and accentuated by later Miocene compression. The most significant exploration risks are charge and the high risk of biodegradation of reservoired liquid hydrocarbons (critically linked to reservoir temperature).
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Rafiqoh, Aunur. "Kaum Perempuan Dalam Cengkraman Hegemoni Budaya Patriarkhi (Book Review)." Musãwa Jurnal Studi Gender dan Islam 5, no. 2 (April 30, 2007): 299. http://dx.doi.org/10.14421/musawa.2007.52.299-308.
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Li, S., W. Yu, J. Fu, Y. Bai, F. Jin, and B. Shangguan. "363 FACTORS INFLUENCING PREGNANCY RATES FOLLOWING TRANSFER OF BOVINE IN VIVO EMBRYOS BIOPSIED FOR SEX DETERMINATION." Reproduction, Fertility and Development 19, no. 1 (2007): 297. http://dx.doi.org/10.1071/rdv19n1ab363.
Повний текст джерелаАнотація:
Data collected from commercial embryo transfer programs in 63 farms in China during June 2002 to December 2005 was analyzed to examine the effects of various factors (biopsy, freezing, sample size, embryo development and quality, in vitro culture, and recipient quality) on pregnancy rates of in vivo-biopsied embryos. Embryos were flushed from superovulated dairy cattle and subjected to a biopsy for sexing determination using protocols and sexing kits supplied by AB Technology Ltd. Fresh embryos were implanted on the same day or frozen with AG freeze medium (AB Technology Ltd., Pullman, WA, USA) for later transfer. Recipients were synchronized with CIDA + PG protocols. Embryos were cultured in 6-well dishes containing 1.3 mL of holding medium (AB Technology Ltd.) in each well at room temperature (20–25�C) for examination of embryo survival in vitro. The chi-square test was used in statistic analysis. The implantation of fresh embryos after biopsy did not affect pregnancy rates (49.6%, 257/518) compared to that of non-biopsied fresh and frozen–thawed embryo groups (52.9%, 47/140 and 46.6%, 177/380, respectively). However, for biopsied embryos subjected to frozen and thawed procedures before implantation, particularly for those subjected to the removal of a larger biopsy, a reduced pregnancy rate was observed (41.8%, 297/710; P < 0.01). Pregnancy rates among biopsied embryos at 3 different development stages (morula-early blastocyst, blastocyst, and expanded blastocyst) were not different. Similar results were found between embryo groups of grade 1 and 2. A significant decrease in pregnancy rate (0/10) was observed with embryos held in vitro for a longer period of time (>5 h), suggesting detrimental effects of in vitro conditions on embryo survival. The highest pregnancy rate (68.0%) was observed in recipients synchronized for the first time before being implanted with biopsied embryos. Significant decreases in such rates were found in recipients synchronized for the second or third times or those with an abortion history at the first or second synchronization-implantation treatment (P < 0.01). Better pregnancy rates (45.6%, 41/90; 46.1%, 76/165; and 45.5%, 5/11) were obtained for recipients implanted with biopsied embryos at Days 7.5, 8.0, and 8.5 post-heat detection, respectively, compared to 16% at Day 7 (3/18, P < 0.05). It is concluded that mechanical treatment (cutting) does not reduce the survival of biopsied embryos; however, cryopreservation reduces their ability to survive in vivo. The analyses also suggest that holding embryos in vitro should not be longer than 5 h unless more favorable in vitro conditions can be provided. To achieve better results of implantation of biopsied embryos, embryo transfer should be performed during 7.5–8.5 days post-estrus, and the healthy recipients synchronized for the first time should be used.
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Agus Rahayu, Disman, Dadang Dahlan, Mokhammad Wahyudin, and Lindawati. "Pengaruh Model Pembelajaran Discovery Learning Untuk Meningkatkan Hasil Belajar Siswa." Widya Accarya 14, no. 1 (April 28, 2023): 1–4. http://dx.doi.org/10.46650/wa.14.1.1343.1-4.
Повний текст джерелаАнотація:
Tujuan dari penelitian ini untuk mengetahui pengaruh model pembelajaran Discovery Learning untuk meningkatkan hasil belajar siswa pada mata pelajaran ilmu pengetahuan sosial (IPS) kelas VIII MTs Ash-shiddiqiyyah Cempaka. Pendekatan penelitian ini menggunakan pendekatan kuantitatif deskriptif dengan jenis penelitian eksperimen, populasi penelitian yaitu seluruh siswa MTs Ash-shiddiqiyyah Cempaka yang berjumlah 320 orang dengan sampel 60 orang siswa yaitu 30 siswa kelompok kontrol yang diterapkan pada kelas VIII dan 30 siswa di kelompok eksperimen yang diterapkan pada kelas VII. Pengumpulan data menggunakan observasi, tes, dan dokumentasi. Analisis data menggunakan analisis deskriptif dan analisis statistik inferensial. Hasil penelitian terdapat pengaruh dari model pembelajaran Discovery Learning untuk meningkatkan hasil belajar siswa di MTs Ash-shiddiqiyyah Cempaka.kelompok kontrol mencapai kategori rendah dan hasil belajar siswa kelompok eksperimen mencapai nilai rata-rata kategori tinggi. Berdasarkan hasil analisis data menunjukkan terdapat perbedaan yang signifikan antara kelompok kontrol dengan kelompok eksperimen, sehingga dapat disimpulkan bahwa pembelajaran Discovery Learning memiliki pengaruh terhadap hasil belajar siswa di MTs Ash-shiddiqiyyah Cempaka Kecamatan Plumbon Kabupaten Cirebon.
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King, Georgina E., Nicholas J. G. Pearce, Helen M. Roberts, Victoria C. Smith, John A. Westgate, David R. Gaylord, and Mark R. Sweeney. "Identification of a Kulshan caldera correlative tephra in the Palouse loess of Washington State, northwest USA." Quaternary Research 86, no. 2 (September 2016): 232–41. http://dx.doi.org/10.1016/j.yqres.2016.06.004.
Повний текст джерелаАнотація:
AbstractThe Kulshan caldera formed at ∼1.15 Ma on the present-day site of Mt. Baker, Washington State, northwest USA and erupted a compositionally zoned (dacite-rhyolite) magma and a correlative eruptive, the Lake Tapps tephra. This tephra has previously been described, but only from the Puget Lowland of NW Washington. Here an occurrence of a Kulshan caldera correlative tephra is described from the Quaternary Palouse loess at the Washtucna site (WA-3). Site WA-3 is located in east-central Washington, ∼340 km southeast of the Kulshan caldera and ∼300 km east-southeast of the Lake Tapps occurrence in the Puget Lowland. Major- and trace element chemistry and location of the deposit at Washtucna within reversed polarity sediments indicates that it is not correlative with the Mesa Falls, Rockland, Bishop Ash, Lava Creek B or Huckleberry Ridge tephras. Instead the Washtucna deposit is related to the Lake Tapps tephra by fractional crystallisation, but is chemically distinct, a consequence of its eruption from a compositionally zoned magma chamber. The correlation of the Washtucna occurrence to the Kulshan caldera-forming eruption indicates that it had an eruptive volume exceeding 100 km3, and that its tephra could provide a valuable early-Pleistocene chronostratigraphic marker in the Pacific Northwest.
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Paraskeuas, Vasileios V., Georgios Papadomichelakis, Ioannis P. Brouklogiannis, Evangelos C. Anagnostopoulos, Athanasios C. Pappas, Panagiotis Simitzis, Georgios Theodorou, Ioannis Politis, and Konstantinos C. Mountzouris. "Dietary Inclusion Level Effects of Yoghurt Acid Whey Powder on Performance, Digestibility of Nutrients and Meat Quality of Broilers." Animals 13, no. 19 (October 4, 2023): 3096. http://dx.doi.org/10.3390/ani13193096.
Повний текст джерелаАнотація:
In recent years, the increasing demand for Greek strained yoghurt produced massive amounts of acid whey, which constitutes a major environmental pollutant. Whether yoghurt acid whey can be included in poultry diets is not known. The purpose of this study was to evaluate the effects of four dietary levels of yoghurt acid whey powder (YAWP) on the growth performance, nutrient digestibility, meat quality traits and oxidative stability. A total of 300 male 1-day-old Ross 308 broilers were assigned into four groups with five replicates of 15 broilers each: control-fed basal diet with no YAWP addition (WO) or basal diet supplemented with YAWP at 25 g/kg of diet (WA), 50 g/kg of diet (WB), or 100 g/kg of diet (WC). At the starter period, body weight and body weight gain were reduced after WB and WC treatments compared to the WO treatment. Breast meat oxidative stability was improved during refrigerated storage for 1 and 3 d in all YAWP treatments compared to control, while the WA treatment showed an improved oxidative stability after 6 and 9 d. The results suggest that YAWP inclusion at 25 g/kg of diet did not impair performance and extended the meat shelf life by reducing lipid oxidation rates.
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Almutairi, K., J. Nossent, D. Preen, H. Keen, and C. Inderjeeth. "OP0100-HPR THE INFLUENCE OF COMORBIDITY ON MORTALITY IN PATIENTS WITH RHEUMATOID ARTHRITIS 1980-2015: A LONGITUDINAL POPULATION-BASED STUDY IN WESTERN AUSTRALIA." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 55–56. http://dx.doi.org/10.1136/annrheumdis-2021-eular.340.
Повний текст джерелаАнотація:
Background:Rheumatoid arthritis (RA) contributes to excess morbidity and mortality in RA patients compared with the general population (1). In Australia, there is a paucity of published literature on the mortality and morbidity rates in RA patients, despite the significant morbidity and mortality burden on health care costs due to RA. Linked data is the preferred method to estimate morbidity and mortality outcomes as they provide the best case-ascertainment.Objectives:To describe temporal changes in mortality rates for patients with RA in relation to comorbidity accrual from 1980-2015 in Western Australia (WA).Methods:Using population-level linked data from WA health administrative datasets (hospital morbidity, emergency department and death data) we followed 17,125 RA patients (ICD-10-AM M05.00–M06.99, ICD-9-CM 714) from 1980- 2015. Comorbidity was ascertained using the Charlson Comorbidity Index (CCI). Mortality rate ratios (MRR) were calculated per decade between the RA cohort and the WA general population by direct age standardisation method, while temporal trends of comorbidities and in-hospital mortality were estimated per 1000 hospital separations in three consecutive decades.Results:During 356,069 patient-years, a total of 8955 (52%) deaths occurred in the RA cohort. The leading causes of deaths were cardiovascular diseases 2386 (26.6%), cancer 1511 (16.8%), rheumatic diseases 519 (5.8%), chronic pulmonary disease 491 (5.5%), dementia 269 (3.0%) and diabetes 235 (2.6%). The highest prevalence of comorbidity (688.6 per 1000 separations) was in the period 1991-2000 following a 1.3% average annual increase since 1980. In-hospital mortality rate was also highest (26.7 deaths per 1000 separations) in the same period. After 2001, both RA comorbidity and mortality rates decreased annually by -0.5% and -4.8%, respectively, with annual changes of -4.4% to -2% and from 2011- 2015, respectively. The overall mortality rate in RA patients after age adjustment was 2.5-times (95%CI: 2.52-2.65) higher than the general population between 1980- 2015 and 1.5-times (95%CI: 1.39-1.81) for the period 2011-2015.Conclusion:The annual comorbidity prevalence and mortality rates in WA have decreased significantly since 2001 reflecting improvements in the management of RA and comorbidity. Nonetheless, the mortality rate in RA patients in WA remains 1.5-times higher than their community counterparts suggesting that there is room to achieve further improvements.References:[1]Meune C, Touze E, Trinquart L, Allanore Y (2009) Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies. Rheumatology (Oxford) 48:1309-1313. doi:10.1093/rheumatology/kep252Table 1.Mortality rates observed among patients with rheumatoid arthritis, based on Charlson Comorbidity Index, per 1000 hospital separations, Western Australia hospitals (1980-2015).Time period1980-19901991-20002001-20102011-2015Total number of hospital separations8209910773118539880410Number of deaths1620287531831277CCI score0481 (29.7%)1024 (35.6%)1197 (37.6%)565 (44.2%)1838 (51.7%)1271 (44.2%)1358 (42.6%)467 (36.6%)2273 (16.8%)518 (18%)581 (18.3%)232 (18.2%)31 (0.1%)4 (0.2%)2 (0.1%)0 (0%)627 (1.7%)58 (2%)45 (1.4%)13 (1%)In-hospital RA mortality per 1000 hospital separation19.726.717.215.9Parentage of average annual change per annum in the period03.8-4.8-2.6Parentage of average annual change since 198001.5-1.4-0.2CCI= Charlson Comorbidity Index.Acknowledgements:Khalid Almutairi was supported by an Australian Government Research Training Program PhD Scholarship at the University of Western Australia.Disclosure of Interests:Khalid Almutairi: None declared, Johannes Nossent Speakers bureau: Janssen, David Preen: None declared, Helen Keen Speakers bureau: Pfizer Australia, Abbvie Australia, Charles Inderjeeth Speakers bureau: Eli Lilly.
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Zhou 周, Zheng 正., Junjie 俊捷 Mao 毛, Taotao 陶陶 Fang 方, Yijun 倚君 Wang 王, Fabrizio Nicastro, and Jiayi 佳怡 Chen 陈. "On the Connection between the Repeated X-Ray Quasiperiodic Oscillation and Warm Absorber in the Active Galaxy RE J1034+396." Astrophysical Journal 967, no. 2 (May 22, 2024): 105. http://dx.doi.org/10.3847/1538-4357/ad3916.
Повний текст джерелаАнотація:
Abstract We conduct an in-depth spectral analysis of ∼1 Ms XMM-Newton data of the narrow line Seyfert 1 galaxy RE J1034+396. The long exposure ensures high spectral quality and provides us with a detailed look at the intrinsic absorption and emission features toward this target. Two warm-absorber (WA) components with different ionization states ( log ( ξ / erg cm s − 1 ) ∼ 4 and log ( ξ / erg cm s − 1 ) ∼ 2.5 – 3 ) are required to explain the intrinsic absorption features in the Reflection Grating Spectrometer spectra. The estimated outflow velocities are around −1400 km s−1 and −(100–300) km s−1 for the high- and low-ionization WA components, respectively. Both absorbers are located beyond the broad-line region and cannot significantly affect the host environment. We analyze the warm absorbers in different flux states. We also examine the 2007 May observation in the low and high phases of quasiperiodic oscillation (QPO). In contrast to previous analyses showing a negative correlation between the high-ionization WA and the QPO phase, we have found no such variation in this WA component. We discover a broad emission bump in the spectral range of ∼12–18 Å, covering the primary features of the high-ionization WA. This emission bump shows a dramatic change in different source states, and its intensity may positively correlate with the QPO phase. The absence of this emission bump in previous work may contribute to the suggested WA–QPO connection.
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Kumar, Vipan, John F. Spring, Prashant Jha, Drew J. Lyon, and Ian C. Burke. "Glyphosate-Resistant Russian-thistle (Salsola tragus) Identified in Montana and Washington." Weed Technology 31, no. 2 (March 2017): 238–51. http://dx.doi.org/10.1017/wet.2016.32.
Повний текст джерелаАнотація:
Two putative glyphosate-resistant (GR) Russian-thistle accessions were collected from fallow fields (wheat-fallow rotation): one from Choteau County, MT (MT-R), and a second from Columbia County, WA (WA-R) in summer/fall of 2015. Greenhouse and outdoor/field whole-plant dose-response studies were conducted to confirm and characterize the levels of glyphosate resistance in these GR accessions relative to known glyphosate-susceptible accessions (MT-S and WA-S from MT and WA, respectively). Based on GR50values of the progeny plants, the MT-R accession exhibited 4.5-fold and 5.9-fold resistance to glyphosate relative to the MT-S accession under greenhouse and outdoor conditions, respectively. The WA-R accession showed 3.0- to 5.0-fold resistance relative to the WA-S accession in greenhouse experiments, and 1.9- to 7.5-fold resistance in multi-site field experiments. In a separate greenhouse study on alternative POST herbicides to control GR Russian-thistle, bicyclopyrone plus bromoxynil, bromoxynil plus fluroxypyr, bromoxynil plus pyrasulfotole, bromoxynil plus MCPA, paraquat alone, paraquat plus metribuzin, saflufenacil alone, saflufenacil plus 2,4-D, and 2,4-D plus bromoxynil plus fluroxypyr provided effective control (≥95%) and shoot dry weight reduction (up to 98%) of GR accessions. This research confirms the first global case of field-evolved GR Russian-thistle. Best management practices (BMPs); including alternative, effective herbicide programs (based on multiple mechanisms of action highlighted in this study) need immediate implementation to prevent further spread of GR or evolution of multiple HR Russian-thistle populations in this region.
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Ferreira, Maria Eliana Camargo, Lara de Souza Soletti, Eduarda Gameleira Bernardino, Heloise Beatriz Quesada, Francielli Gasparotto, Rosângela Bergamasco, and Natália Ueda Yamaguchi. "Synergistic Mechanism of Photocatalysis and Photo-Fenton by Manganese Ferrite and Graphene Nanocomposite Supported on Wood Ash with Real Sunlight Irradiation." Catalysts 12, no. 7 (July 7, 2022): 745. http://dx.doi.org/10.3390/catal12070745.
Повний текст джерелаАнотація:
The present research aimed to evaluate the photocatalytic activity of reduced graphene oxide and manganese ferrite nanocomposite supported on eucalyptus wood ash waste (WA) from industrial boilers, for the decolorization of methylene blue (MB) solutions, using sunlight as an irradiation source. For this, the photocatalyst named MnFe2O4-G@WA was synthesized by a solvothermal method and characterized by analyzes of scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, Brunauer–Emmett–Teller and zeta potential. Firstly, the photocatalyst was evaluated for photocatalytic decolorization of MB under different reaction conditions. Then, the influence of pH, photocatalyst dose and H2O2 was evaluated. MnFe2O4-G@WA showed 94% of efficiency for photocatalytic decolorization of MB under operating conditions of solar irradiation, 0.25 g/L of catalyst, 300 mg/L of H2O2. The proposed degradation reaction mechanism suggested that the photodegradation of MB was through a synergistic mechanism of photocatalysis and photo-Fenton reactions, with the combined action of the three materials used. The data adjusted to the first order kinetics from the Langmuir–Hinshelwood model. In addition, MnFe2O4-G@WA showed high stability, maintaining its efficiency above 90% after 5 cycles. The results indicated that the nanophotocatalyst is a potential technology for the decolorization of MB solutions.
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Koutsos, Athanasios, Samantha Riccadonna, Maria M. Ulaszewska, Pietro Franceschi, Kajetan Trošt, Amanda Galvin, Tanya Braune, et al. "Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial." American Journal of Clinical Nutrition 111, no. 2 (December 16, 2019): 307–18. http://dx.doi.org/10.1093/ajcn/nqz282.
Повний текст джерелаАнотація:
ABSTRACT BACKGROUND Apples are rich in bioactive polyphenols and fiber. Evidence suggests that consumption of apples or their bioactive components is associated with beneficial effects on lipid metabolism and other markers of cardiovascular disease (CVD). However, adequately powered randomized controlled trials are necessary to confirm these data and explore the mechanisms. OBJECTIVE We aimed to determine the effects of apple consumption on circulating lipids, vascular function, and other CVD risk markers. METHODS The trial was a randomized, controlled, crossover, intervention study. Healthy mildly hypercholesterolemic volunteers (23 women, 17 men), with a mean ± SD BMI 25.3 ± 3.7 kg/m2 and age 51 ± 11 y, consumed 2 apples/d [Renetta Canada, rich in proanthocyanidins (PAs)] or a sugar- and energy-matched apple control beverage (CB) for 8 wk each, separated by a 4-wk washout period. Fasted blood was collected before and after each treatment. Serum lipids, glucose, insulin, bile acids, and endothelial and inflammation biomarkers were measured, in addition to microvascular reactivity, using laser Doppler imaging with iontophoresis, and arterial stiffness, using pulse wave analysis. RESULTS Whole apple (WA) consumption decreased serum total (WA: 5.89 mmol/L; CB: 6.11 mmol/L; P = 0.006) and LDL cholesterol (WA: 3.72 mmol/L; CB: 3.86 mmol/L; P = 0.031), triacylglycerol (WA: 1.17 mmol/L; CB: 1.30 mmol/L; P = 0.021), and intercellular cell adhesion molecule-1 (WA: 153.9 ng/mL; CB: 159.4 ng/mL; P = 0.028), and increased serum uric acid (WA: 341.4 μmol/L; CB: 330 μmol/L; P = 0.020) compared with the CB. The response to endothelium-dependent microvascular vasodilation was greater after the apples [WA: 853 perfusion units (PU), CB: 760 PU; P = 0.037] than after the CB. Apples had no effect on blood pressure or other CVD markers. Conclusions These data support beneficial hypocholesterolemic and vascular effects of the daily consumption of PA-rich apples by mildly hypercholesterolemic individuals. This trial was registered at clinicaltrials.gov as NCT01988389.
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Stark, A., X. \( Yan, R. Stapp, A. Raghunathan, L. Kirchner, J. Griggs, L. A. Newman, A. W. Dick, and D. Chitale. "Ductal carcinoma in situ (DCIS) of the breast: Race- and treatment-adjusted specific disease-free probability." Journal of Clinical Oncology 29, no. 27_suppl (September 20, 2011): 186. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.186.
Повний текст джерелаАнотація:
186 Background: Findings of DCIS outcome between African-American (AA) and White-American (WA) women are inconclusive. Methods: We conducted a retrospective longitudinal study with the objective of comparing the risk of any second breast cancer after the first primary DCIS, adjusting for pathologic prognostic indicators, treatment, age, and the established epidemiologic risk factors. Women were diagnosed and treated in one institution between 1990-1999. Diagnostic slides were reviewed and prognostic indicators documented; demographic, clinical and method of detection, screening mammography vs. palpation, were collected from medical records. We applied Accelerated Failure Time Modeling (AFTM) to determine the variables that were best associated with the risk of a second cancer. Results: 335 women, 29.6% (n=100) AA with mean age of 60 (±13) and 70.4% (n=235) WA with mean age of 57 (±12.4), contributed to this study. Distributions of some of the prognostic indicators and final treatment are presented. (Table) During the 10 years of follow-up 12.0% (n=12) of AA and 3.0% (n=7) WA experienced second cancer in ipsilateral breasts; 5.0% (n=5) of AA and 3.8% (n=9) WA in their contralateral breasts and 2 women, 1 AA and 1 WA, in both breasts. Results from the AFTM yielded race as the only variable associated with the risk of a second cancer but only in ipsilateral breasts (HR= 4.11, 95% CI=1.6-10.5 p=0.003). Conclusions: No difference in the risk of a second cancer in contralateral breast between AA and WA women support the notion of equal access and equal treatment in comparable treatment outcome. Reasons for increased risk of a second cancer in ipsilateral breast in AA women are being evaluated. [Table: see text]
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Wayne, Adrian. "New Conservation Initiative to Save the Woylie from Extinction in the Wild." Pacific Conservation Biology 15, no. 4 (2009): 233. http://dx.doi.org/10.1071/pc090233.
Повний текст джерелаАнотація:
Six hundred thousand dollars was recently pledged by the Western Australian (WA) Government to fund an Emergency Conservation Action plan for the Woylie Bettongia penicillata ogilbyi to establish insurance populations at risk of extinction in the wild. $500,000 will be used by The Department of Environment and Conservation to establish a 400 ha predator-free enclosure in the Perup Nature Reserve (300 km south of Perth, WA) that should be capable of naturally supporting up to 500 woylies. At least 40 founders will be sourced from the surrounding area, which previously constituted the largest of three indigenous populations that persisted after pan-continental declines of the species in the 19th and 20th centuries.
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Rosa, Vinicius, Bárbara Pick, Tatiana Rocha Azeredo, Eduardo Augusto Mascarenhas Cruz Filho, and Walter Gomes Miranda Júnior. "Are Flowable Resin-Based Composites a Reliable Material for Metal Orthodontic Bracket Bonding?" Journal of Contemporary Dental Practice 11, no. 4 (2010): 17–24. http://dx.doi.org/10.5005/jcdp-11-4-17.
Повний текст джерелаАнотація:
Abstract Aim To compare the tensile bond strength (TBS) and adhesive remnant index (ARI) of three flowable resin-based composites and three orthodontic adhesive systems for metal bracket bonding. Methods and Materials Sixty bovine incisors were randomly divided into six groups. Enamel surfaces were etched with 37 percent phosphoric acid for 30 seconds and stainless steel orthodontic brackets were bonded using either flowable resinbased composites (3M Flow, FL; Tetric Flow, TF; and Wave, WA) or orthodontic bonding systems (Transbond XT, TX; Concise Orthodontic, CO; Fill Magic Ortodôntico, FM). All specimens were thermal cycled and stored in distilled water at 37°C for 24 hours, after which they were subsequently tested for TBS using a universal testing machine. ARI scores were determined after the failure of brackets. TBS and ARI data were submitted to ANOVA, Tukey, and Kruskal-Wallis tests (p=0.05), respectively. Results Rankings of the resin-based composites based on TBS means (MPa) were TX (6.4±2.1), followed by CO (4.5±2.7), FM (3.7±1.2), FL (3.6±1.2), TF (3.3±1.2), and WA (2.4±0.6). CO exhibited the lowest ARI mean score (0.9±1.2) which was significantly different from the other five materials: TX (2.8±0.42), FM (2.8±0.42), FL (2.9±0.32), TF (2.9±0.32), and WA (3.0±0.01). However, there were no statistically significant differences among the other groups with mean scores of 2.8–3.0. A score of 3.0 indicated that all the resin remained bonded to the tooth surface. Conclusions The flowable resin-based composites tested (Fl, TF, and WA) used to bond metal orthodontic brackets to bovine enamel had low mean TBS values but acceptable ARI mean scores. Clinical Significance Flowable composites may not be appropriate for bracket bonding, unless the teeth to be bonded are not subjected to higher orthodontic stresses, such as those without an antagonist. Citation Pick B, Rosa V, Azeredo TR, Filho EAMC, Miranda Júnior WG. Are Flowable Resin-Based Composites a Reliable Material for Metal Orthodontic Bracket Bonding? J Contemp Dent Pract [Internet]. 2010 July; 11(4):017-024. Available from: http://www.thejcdp.com/journal/ view/volume11-issue4-pick
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Davies-Adetugbo, Anita A., and K. Adetugbo. "Effect of Early Complementary Feeding on Nutritional Status in Term Infants in Rural Nigeria." Nutrition and Health 12, no. 1 (July 1997): 25–31. http://dx.doi.org/10.1177/026010609701200103.
Повний текст джерелаАнотація:
Breastfeeding is common in developing countries, but exclusive breastfeeding is rare, and complementary foods are introduced at an early age. The objective of the present study is to determine the effect of early complementary feeding on the nutritional status of infants. Weight-for-age (WA) indices have been determined for 82 infants 3 to 4 months old participating in a breastfeeding study. They included 42 that started complementary feeding early (before 2 months) and 40 that started later. Weight-for-age indices were significantly lower for the early group than the later group (t =3.00, p =0.004). The prevalence of underweight (WA SO scores below -2.0) was 7.5% in the later complementary feeding group and 28.6% in the early group (χ2 =4.76, p =0.0292). Severe underweight (WA SD scores below -3.0) prevalences were 0% and 14.3% respectively (p = 0.0259). Thus, poorer nutritional status was significantly associated with earlier complementary feeding. The results suggest that exclusive breastfeeding, (together with promotion of weaning education and growth monitoring) should be vigorously promoted in these rural communities.
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Retnowati, Eka, and Raharja Raharja. "Analisis Pengaruh Total Quality Management (TQM) Terhadap Kinerja Organisasi Dengan Pengendalian Internal Sebagai Variabel Intervening (Studi Empiris Anggota Puskopsyah BMT Jawa Tengah)." Disclosure: Journal of Accounting and Finance 3, no. 1 (May 28, 2023): 44. http://dx.doi.org/10.29240/disclosure.v3i1.6546.
Повний текст джерелаАнотація:
This research is generally aimed empirically in testing the implementation of total quality management (TQM) on organizational performance by applying the implementation of internal control structure as intervening variable. In the implementation of total quality management (TQM) on Baitul Maal Wa Tamwil is associated with the internal control structure of Baitul Maal Wa Tamwil Puskopsyah member of the performance. This research uses quantitative method by using Structural Equation Model (SEM) based on Partial Least Square (PLS) 3.0 component. In the research object, all Baitul Maal Tamwil were selected as the population while the sample in this study focused on members of Puskopsyah (Pusat Koperasi Syariah) BMT (Baitul Maal Wa Tamwil) Central Java, which sampling based on purposive sampling method with total sample there are 97 respondents. The results of this study indicate that the implementation of total quality management (TQM) does not directly affect the performance of the organization but has an effect on the implementation of internal control structure which is the mediator of the relationship between total quality management (TQM) and organizational performance.
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Graham, Kate L., Yoshikazu Takada та Barbara S. Coulson. "Rotavirus spike protein VP5* binds α2β1 integrin on the cell surface and competes with virus for cell binding and infectivity". Journal of General Virology 87, № 5 (1 травня 2006): 1275–83. http://dx.doi.org/10.1099/vir.0.81580-0.
Повний текст джерелаАнотація:
Rotaviruses recognize several cell-surface molecules, including the α2β1 integrin, and the processes of rotavirus cell attachment and entry appear to be multifactorial. The VP5* subunit of the rotavirus spike protein VP4 contains the α2β1 ligand sequence Asp–Gly–Glu at residues 308–310. Binding to α2β1 and infectivity of monkey rotavirus strain RRV and human rotavirus strain Wa, but not porcine rotavirus strain CRW-8, are inhibited by peptides containing Asp–Gly–Glu. Asp308 and Gly309 are necessary for the binding of RRV VP5* (aa 248–474) to expressed I domain of the α2 integrin subunit. Here, the ability of RRV VP5* to bind cells and affect rotavirus–integrin interactions was determined. Interestingly, VP5* bound to cells at 4 and 37 °C, both via α2β1 and independently of this integrin. Prior VP5* binding at 37 °C eliminated RRV binding to cellular α2β1 and reduced RRV and Wa infectivity in MA104 cells by 38–46 %. VP5* binding did not affect the infectivity of CRW-8. VP5* binding at 4 °C did not affect permissive-cell infection by RRV, indicating an energy requirement for VP5* competition with virus for infectivity. Mutagenesis of VP5* Asp308 and Gly309 eliminated VP5* binding to α2β1 and the VP5* inhibition of rotavirus cell binding and infection, but not α2β1-independent cell binding by VP5*. These studies show for the first time that expressed VP5* binds cell-surface α2β1 using Asp308 and Gly309 and inhibits the infection of homologous and heterologous rotaviruses that use α2β1 as a receptor.
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Johnson, Willard C., William O. Williford, John D. Corson, and Frank T. Padberg. "Hemorrhagic Complications during Long-Term Postoperative Warfarin Administration in Patients Undergoing Lower Extremity Arterial Bypass Surgery." Vascular 12, no. 6 (November 2004): 362–68. http://dx.doi.org/10.1258/rsmvasc.12.6.362.
Повний текст джерелаАнотація:
Lower extremity bypass procedures restore function and prevent amputation in many patients with severe peripheral arterial occlusive disease. The regular postoperative use of aspirin offers the dual benefit of extending bypass patency and patient survival. Previous trials of adjunctive oral anticoagulant therapy with warfarin have infrequently combined warfarin with aspirin. We hypothesized that the addition of oral anticoagulant therapy would further enhance the benefits of aspirin but may increase the risk of clinically important bleeding. Eligible patients ( N = 831) scheduled for elective lower extremity arterial bypass surgery were randomized to receive either warfarin plus aspirin (WA) ( n = 418) or aspirin alone ( n = 413). At monthly intervals, the warfarin dose was adjusted to a target international normalized ratio (INR) of 1.4 to 2.8; both groups received aspirin (325 mg/d). The end point of major hemorrhagic events, defined as intracranial hemorrhage or bleeding that required intervention, is reported, and INR values and compliance with warfarin therapy are presented. Major hemorrhagic events occurred more frequently in the WA group (35 in the WA group vs 15 in the aspirin group; p = .02) during a mean follow-up of 38 months. In the WA group, an intracranial hemorrhage occurred in six patients (two had an INR > 3.0), of whom four died; one subdural hemorrhage occurred in the aspirin group. Transfusions and interventions for bleeding were more frequent in the WA group, as were minor bleeding events. Of the 8,946 INR determinations, 58% were in the target range, whereas a higher value occurred in 10% and a lower value in 32%. Compliance with warfarin was maintained in 65% of the patients after the first year of observation. In patients with elective lower extremity bypass procedures, the postoperative adjunctive use of warfarin with aspirin increased the risk of major hemorrhagic events. Most of these events occurred when the INR was in the target range.
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Wang, Yajing, Juan Li, Ru Lin, Dianrun Gu, Yuanfang Zhou, Han Li, and Xiangdong Yang. "Recommended Values for the Hydrophobicity and Mechanical Properties of Coating Materials Usable for Preparing Controlled-Release Fertilizers." Polymers 15, no. 24 (December 12, 2023): 4687. http://dx.doi.org/10.3390/polym15244687.
Повний текст джерелаАнотація:
The hydrophobicity and mechanical properties of coating materials and the nitrogen (N) release rates of 11 kinds of controlled-release fertilizers (CRFs) were determined in this study. The results show that the N release periods of the CRFs had negative correlations with the water absorption (WA) of the coating materials (y = 166.06x−1.24, r = 0.986), while they were positively correlated with the water contact angle (WCA) and elongation at break (EB) (y = 37.28x0.18, r = 0.701; y = −19.42 + 2.57x, r = 0.737). According to the fitted functional equation, CRFs that could fulfil the N release period of 30 days had a coating material WA < 2.4%, WCA > 68.8°, and EB > 57.7%. The recommended values for a CRF that can fulfil the N release period of 30 days are WA < 3.0%, WCA > 60.0°, and EB > 30.0% in the coating materials. CRFs with different nutrient release periods can be designed according to the recommended values to meet the needs of different crops. Furthermore, our experiments have illustrated that the N release period target of 30 days can be reached for modified sulfur-coated fertilizers (MSCFs) by improving their mechanical properties.
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Räihä, Tapio, Iiro Nerg, Heidi Jurvelin, Andrew Conlin, Marko Korhonen, and Leena Ala-Mursula. "Evening chronotype is associated with poor work ability and disability pensions at midlife: a Northern Finland Birth Cohort 1966 Study." Occupational and Environmental Medicine 78, no. 8 (February 23, 2021): 567–75. http://dx.doi.org/10.1136/oemed-2020-107193.
Повний текст джерелаАнотація:
ObjectivesThis is the first general population study to evaluate whether evening chronotypes (E) have poorer work ability (WA) and higher probability for early disability pensions (DPs) than morning types (M) in middle age.MethodsAmong non-retired individuals (n=5831; 2672 men, 3159 women) of the Northern Finland Birth Cohort 1966, chronotype was determined at the age of 46 years with shortened Morningness–Eveningness Questionnaires in 2012. The outcomes were poor WA in 2012, indicated by scores 0–7/10 of Work Ability Score, and registered emergence of DPs in 2013–2016. Multivariate logistic and Cox regression analyses were separately adjusted for factors related to sleep, health and behaviours, sociodemographic and economic factors, or working times.ResultsE-types represented 10% (n=264) of men and 12% (n=382) of women. Compared with M-types, the unadjusted ORs with 95% CIs of poor WA for E-type men and women were 2.24 (95% CI 1.62 to 3.08) and 2.33 (95% CI 1.74 to 3.10), respectively. The odds remained statistically significant and approximately twofold in all separate adjustment models tested. During 2013–2016, 8 (3.0%) E-type men and 10 (2.6%) E-type women were granted DP, which, compared with M-types, represented a higher HR that was statistically significant for men (HR 3.12, 95% CI 1.27 to 7.63) and remained significant except when multiple sleep variables or working times were adjusted for.ConclusionsEveningness appears a previously unrecognised risk factor for poor WA and early disability. We suggest that individual chronotype be considered in attempts to lengthen work careers.
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Alamshah, Anisah, Musafir Pababbari, and Syamzan Syukur. "Metode Penulisan Sejarah Kitab Tarikh Al-Umam Wa Al-Muluk Karya Al-Thabari." Rihlah: Jurnal Sejarah dan Kebudayaan 11, no. 01 (December 1, 2023): 1–20. http://dx.doi.org/10.24252/rihlah.v11i01.42403.
Повний текст джерелаАнотація:
Tarikh al-Umam wa al-Muluk, yang juga dikenal sebagai Tarikh al-Rusul wa al-Muluk, sebuah karya monumental dalam historiografi tradisional Islam. Meskipun karya ini diakui sebagai salah satu referensi utama dalam kajian Islam klasik, terdapat kritik terhadap gaya penulisannya yang dianggap kurang sistematis dan kurang interpretatif. Hal ini berdampak pada preferensi terhadap karya-karya orientalis yang dianggap lebih rasional dan kritis. Dengan menggunakan teknik penelitian sejarah yang bersifat deskriptif-analitik, penelitian ini melibatkan 4 tahapan yaitu heuristik, kritik, interpretasi dan historiografi. Hasil penelitian ini mengungkapkan argumen bahawa Al-Thabari adalah ulama terkenal pada masa Abbasiyah, lahir pada tahun 225 H dan meninggal pada tahun 310 H. Kondisi lingkungannya secara sosio-politik turut mempengaruhi pola pikir dan nuasa penulisannya mengumpulkan informasi dari berbagai sumber, termasuk kitab tafsir, sirah, dan sejarah. Tarikh al-Umam wa al-Muluk dianggap sebagai salah satu prestasi terbesar al-Thabari dalam menulis sejarah. Kitab ini membahas berbagai topik, termasuk kehidupan Nabi Muhammad saw., peristiwa di Makkah dan Madinah, peperangan, serta periode Khulafa al-Rasyidin, Dinasti Umayyah, dan Dinasti Abbasiyah. Dalam penulisan kitab ini, al-Thabari menggunakan metode sistematika kronologis, mengandalkan riwayat dan sanad, bergantung pada referensi, menggabungkan cerita secara tekstual, dan menyertakan teks-teks sastra. Meskipun kitab ini dianggap penting, terdapat beberapa kritik terhadapnya. Salah satunya adalah kurangnya fokus pada peristiwa penting, seperti kekuasaan Dinasti Umayyah di Andalusia. Selain itu, kitab ini dianggap kurang objektif karena bersifat deskriptif-naratif tanpa analisis, serta mengandung banyak cerita hayalan terutama pada periode pra-Islam.
Kata kunci: tarikh wa al-muluk, al-thabari, historiografi tradisional islam, kritik, metode penulisan
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Muhammad Fithri Umam. "TELAAH KRITIS TERHADAP PERIODISASI KODIFIKASI MUḤAMMAD ḤUSAYN AL-DHAHABĪ DALAM AL-TAFSĪR WA AL-MUFASSIRŪN". AL ITQAN: Jurnal Studi Al-Qur'an 2, № 2 (16 серпня 2016): 1–42. http://dx.doi.org/10.47454/itqan.v1i1.12.
Повний текст джерелаАнотація:
Tulisan ini mencoba menelaah secara kritis sejarah perkembangan tafsir pada era kodifikasi hasil periodisasi Muḥammad Ḥusayn al-Dhahabī dalam karya monumentalnya, al-Tafsīr wa al-Mufassirūn. Al-Dhahabī mengklasifikasi periode kodifikasi tafsir menjadi lima tahap (al-khaṭwah). Menurutnya, kompilasi dan kodifikasi tafsir yang mencakup ayat per-ayat, surat per-surat, dan disusun secara mandiri tidak menumpang dalam bagian bab-bab hadis, juga sistematis sesuai urutan mushaf demikian itu baru dilakukan pada era tābi’ tābi’i al-tabi’īn, seperti Ibnu Mājah (w. 273 H), al-Ṭabarī (w. 310 H), dan ulama setelahnya. Tujuan tulisan ini adalah untuk menguji akurasi periodisasi al-Dhahabī tersebut. Sehingga memakai analisis verikatif-kualitatif yang meliputi verifikasi autentisitas atau keaslian sumber, dan kredibilitas. Ditambah keterangan dari kitab-kitab tārīkh, tarājim, ṭabaqāt, yang banyak mengeksplorasi sejarah masa lalu, menuntut tulisan ini mengkritisi periodisasi yang dipetakan oleh al-Dhahabī. Kata Kunci : Sejarah, Kodifikasi, al-Tafsīr wa al-Mufassirūn, dan Kritik.
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Kersten, Christian, Milada Cvancarova, Geir Boehler, Svein Mjaaland, and Odd Mjaaland. "Does in-house availability of multidisciplinary teams increase survival in upper GI cancer?" Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 4066. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4066.
Повний текст джерелаАнотація:
4066 Background: Treatment of esophageal, gastric and pancreatic cancers (UGI) is recommended to be discussed by a multidisciplinary team (MDT), despite lack of evidence that this approach leads to increased survival. In 2001, a cancer centre with irradiation and chemotherapy facilities was established in the Norwegian county of West Agder (WA), providing the potential for local in-house MDT meetings. Our primary objective was to evaluate the effect of the establishment of in-house MDT availability (iMDTa) on survival in a cohort of UGI patients in WA. We compared survival figures for WA with those of other Norwegian counties with complete, less complete and without iMDTa. Methods: We defined “iMDTa” as a single administrative institution with all departments on one campus, serving the population of one county. We compared cause-specific survival rates for 2000-04 and 2005-08 for UGI patients living in counties with (MDT-Yes), without (MDT-No) and with a mix (MDT-mix) of iMDTa, with the county of WA which had a change in iMDTa (MDT-Change) during the study period. Crude survival was modelled with Kaplan-Meier method and Cox regression analysis was used to adjust for age and region (sex and stage distributions were similar in all counties). Results: We analyzed 12530 UGI patients living in five Norwegian regions. Median age was 74 (17-98) yrs and median follow-up was 5 (0-138) months. The regions with the highest level of iMDTa achieved the largest increases in survival, compared to the counties with limited or no iMDTa. Median overall survival for all UGI patients in WA/MDT-Change increased from 129 to 300 days from 2000-8, p=0.001. Compared to the county with MDT-Mix, the county with MDT-Change reached a statistically significant reduction in the risk of death (HR) for both esophageal (1.12- 0.60) and stomach cancers (0.87-0.63), but not for pancreatic cancers (1.04-1.01). Conclusions: In parallel with an increasing use of in-house MDT, we found a striking and more than two-fold increase in survival in the Norwegian county of WA/MDT-Change. This survival gain is partly explained by increased use of chemotherapy. During the same time period, no increase in survival was found in the MDT-No or MDT-Mix counties.
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Salim, Ana Paula AA. "Understanding Consumers' Perception of Different Fish Species Marketed in Brazil using Word Association." Open Access Journal of Agricultural Research 7, no. 2 (2022): 1–8. http://dx.doi.org/10.23880/oajar-16000293.
Повний текст джерелаАнотація:
Word association (WA) is a qualitative technique widely used to understand how consumers perceive food products. The aim of the present study was to investigate the consumer's perception (n = 300) regarding five different fish species marketed in Brazil and to elucidate whether the perception is affected by the consumption frequency using the WA task. Samples of the panga, tuna, salmon, tilapia, and hake were utilized in this study. Different perceptions were identified for both frequent and occasional fish consumers. Among 17 categories elicited to describe the fish species, almost all categories presented significant differences in the frequency of mention according to the chi-square per cell approach (p ≤.001). The conceptualization of each species of fish was strongly affected by the frequency of consumption of this matrix. The findings from the present work provided a insight into Brazilian consumers' perception of fish meat, which can be used to develop strategies to increase the commercialization of these species in the Brazilian market.
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Dias, Adriano, and João Marcos Bernardes. "O4B.1 The impact of manual patient handling on work ability: a cross-sectional study." Occupational and Environmental Medicine 76, Suppl 1 (April 2019): A34.1—A34. http://dx.doi.org/10.1136/oem-2019-epi.91.
Повний текст джерелаАнотація:
This cross-sectional study investigated the level of work ability (WA) and its association with manual patient handling (MPH) in healthcare workers (HCW). Participants were HCWs working at the University Hospital of Botucatu Medical School, who were willing to participate and provided written informed consent. Of the 488 HCWs who were invited, 320 participated for a response rate of 65.6%. Sixteen participants (5%) were subsequently excluded from data analysis due to missing data. Data were collected using a self-administered anonymous paper questionnaire containing seven parts: manual patient handling, low back pain, demographic characteristics, occupational variables, psychosocial work conditions, lifestyle variables and work ability. Work ability was measured by the Brazilian version of the Work Ability Index (WAI). The association between WA and LBP was analyzed using a Poisson regression model. Initially, simple Poisson regression models with robust variance were conducted for each covariate. Those variables with a p value ≤ 0.25 were selected for inclusion in a multiple Poisson regression model with robust variance, and those with p<0.05 were considered statistically significant. Most respondents were female (83.6%), the mean age was 40.35 years (SD 9.74, range 22-66) and the average duration of employment was 10.67 years (SD 9.36, range 1-40). The WAI mean score was 38.03 points (SD 6.15, 95% CI 37.33-38.72), and the prevalence of adequate WA (equal to or above 37 points) was 56.58%. In the multiple Poisson regression model, MPH (PR 1.375, 95% CI 1.038-1.821) was significantly associated with WA, even when adjusted for the covariates. Thus, hospital managers should plan and implement interventions to maintain healthcare workers’ work ability, and these interventions should include the limitation of manual patient handling activities.
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Ball, William J. "Book Reviews : Beyond the Home Page Book Review Essay on Guides to Advanced Content Creation for the Web Introducing Microsoft FrontPage97. Kerry A. Lehto and W. Brett Polonsky. Redmond, WA: Microsoft Press, 1997. 384 pp., $24.99. Microsoft FrontPage97 Step by Step. Catapult Inc. Redmond, WA: Microsoft Press, 1997. 286 pp., $29.99. Web Scripting Secret Weapons. Scott Walker. Indianapolis, IN: Que Corp., 1997. 380 pp., $39.99. Special Edition Using JavaScript. Mark C. Reynolds. Indianapolis, IN: Que Corp., 1997. 831 pp., $49.99. VBScript by Example. Jerry Honeycutt. Indianapolis, IN: Que Corp., 1997. 355 pp., $34.99. Building VRML Worlds. Ed Tittle, Charlie Scott, Paul Wolfe, and Claire Sanders. Berkeley, CA: Osborne/McGraw Hill, 1997. 381 pp., $39.95." Social Science Computer Review 15, no. 4 (December 1997): 446–50. http://dx.doi.org/10.1177/089443939701500411.
Повний текст джерела
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Nagata, Akihito, Noriko Doki, Yuki Otsuka, Ryosuke Konuma, Hiroto Adachi, Atsushi Wada, Kenya Toma, et al. "Weight Adjusted Urinary Creatinine Excretion Predicts Transplant Outcomes in Adult Patients with Acute Myeloid Leukemia in Complete Remission." Blood 134, Supplement_1 (November 13, 2019): 4609. http://dx.doi.org/10.1182/blood-2019-125228.
Повний текст джерелаАнотація:
Background: Sarcopenia, the loss of muscle mass, has been recognized as a prognostic factor for cancer patients. For example, low body mass index (BMI) was reported to be a risk of poor overall survival (OS) among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. However, low BMI was not associated with high non-relapse mortality (NRM) rate, and BMI may not directly reflect the physical condition. (Bone Marrow Transplant. 2014;49:1505-12). To evaluate the clinical impact of the muscle volume on the prognosis of allo-HSCT recipients, other biomarkers that directly reflect muscle mass may be warranted. Urinary creatinine excretion (UCE) has been reported to estimate muscle mass and have prognostic value for kidney transplant patients (Transplantation. 2008;86:391-8.). There is no report to evaluate clinical impact of UCE on the prognosis of allo-HSCT recipients. Therefore, we retrospectively analyzed the association between pre-transplant UCE and the transplant outcomes. Methods: We included 173 adult patients with acute myeloid leukemia (AML) in complete remission (CR) who underwent first allo-HSCT from 2006 to 2017 at our institute and measured UCE before allo-HSCT. Concerned the possibility of urine storage failure, two patients with low total daily urine volume (<0.5L/day) were excluded from this analysis. Therefore, we investigated the remaining 171 patients. In order to correct the physical disparities of individual patients, we evaluated the clinical impact of weight adjusted UCE (WA-UCE) ,i.e UCE / body weight [μmol/kg/day] (Intensive Care Med. 2018;44:1699-708.). We used receiver operating characteristics curve in order to determine the cutoff value of the WA-UCE and classified the patients into the high and low WA-UCE group. We evaluated transplant outcomes such as OS, progression-free survival (PFS), NRM, and cumulative incidence of relapse (CIR) between two groups. Results: The median age at allo-HSCT was 52 (range, 18-73) and there were more male patients (n=111) than female patients (n=60). Regarding cytogenetic risk, 15 (9.1%), 112 (65.8%), and 38 (23.0%) were categorized as favorable, intermediate, and poor risk, respectively (There were five patients without cytogenetic data). The median follow-up period of survivors was 704 (range, 9 to 3,857) days. We defined the cutoff value of the weight adjusted UCE as 148 μmol/kg/day in male and 128 μmol/kg/day in female. Among 171 patients, 90 patients (male = 59, female = 31) were in the high WA-UCE group and 81 patients (male = 52, female = 29) were in the low WA-UCE group. We found no significant differences between two groups in terms of the number of relapse before allo-HSCT, cytogenetic risks, conditioning regimens, hematopoietic cell transplantation comorbidity index, donor-recipient HLA matching, donor source, or estimated glomerular filtration rate. On the other hand, patient's age at allo-HSCT was significantly younger (low vs. high WA-UCE group: median, 53 [range, 18 - 73] vs. 48 [range, 19 - 68] years, P = 0.02) and BMI was lower (low vs. high WA-UCE group: median, 22.3 [range, 15.4 - 38.8] vs. 21.9 [range, 15.4 - 29.3] kg/m2, P = 0.003) in high WA-UCE group. In univariate analysis, we observed a significant difference in OS, PFS, and NRM between two groups (low vs. high WA-UCE group: 1-year OS, 60.1% vs. 80.9%, P < 0.01; 1-year PFS, 54.1% vs. 70.9%, P = 0.02; 1-year NRM, 24.8% vs. 12.3%, P = 0.02) (Figure1). On the other hand, there was no significant difference in 1-year CIR between two groups (low vs. high WA-UCE group: 21.1% vs. 16.8%, P = 0.63). In our cohort, the low BMI (< 18.5 kg/m2) was not significantly associated with OS, PFS, CIR, and NRM (low vs. high BMI group: 1-year OS, 77.6% vs. 69.9%, P = 0.51; 1-year PFS, 74.1% vs. 60.9%, P = 0.45; 1-year CIR, 14.8% vs. 19.5%, P = 0.02, 1-year NRM, 11.1% vs. 19.5%, P = 0.70) In multivariate analysis, the low WA-UCE was an independent risk factor for OS (Hazard ratio (HR) [95% confidence interval (CI)]; 2.29 [1.38 - 3.80], P < 0.01), PFS (HR [95% CI]; 1.76 [1.11 - 2.79], P = 0.02), and NRM (HR [95% CI]; 2.22 [1.13 - 4.36], P = 0.02) (table1). Conclusion: In allo-HSCT adult recipients with AML in CR, low WA-UCE before transplantation was associated with poor prognosis, which related to high NRM within 1 year. WA-UCE can be an independent, objective, simple, and reliable biomarker for evaluating muscle mass and predicting transplant outcome. Disclosures No relevant conflicts of interest to declare.
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McDonough, Daniel, Zachary Pope, Nan Zeng, Jung Lee, and Zan Gao. "Comparison of College Students’ Energy Expenditure, Physical Activity, and Enjoyment during Exergaming and Traditional Exercise." Journal of Clinical Medicine 7, no. 11 (November 10, 2018): 433. http://dx.doi.org/10.3390/jcm7110433.
Повний текст джерелаАнотація:
This study evaluated the effects of exergaming on college students’ energy expenditure (EE), moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), rating of perceived exertion (RPE), and enjoyment compared to traditional treadmill exercise, and sex differences. Sixty college students (30 female; X ¯ age = 23.6 ± 4.1 years) completed three 20-min exercise sessions on Xbox 360 Kinect Just Dance (Microsoft, Redmond, WA, USA), Xbox 360 Kinect Reflex Ridge (Microsoft, Redmond, WA, USA), and treadmill walking. Their EE and PA were assessed by ActiGraph accelerometers (ActiGraph Co.; Pensacola, FL, USA); RPE every four min; enjoyment via an established scale. Significant exercise-type by sex interaction effects were observed for RPE (p < 0.01): females reported significantly lower RPE during exergaming sessions but significantly higher RPE during treadmill walking. Results revealed significant main effects for all outcomes between exercise sessions (all p < 0.01): treadmill walking resulted in significantly higher metabolic equivalents (METs), MVPA, and EE (p < 0 .01), yet lower LPA (p < 0.01), compared to the two exergaming sessions. Participants’ RPE was significantly higher during treadmill walking than during exergaming sessions, with exergaming eliciting significantly higher enjoyment (all p < 0.01). College students find exergaming more enjoyable and report lower RPE compared to traditional treadmill exercise, though not yet matching the moderate physiological intensity level.
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Sihombing, Suriady, Wilson Sabastian Nababan, Miduk Tampubolon, and Cris Stevan Turnip. "Analisa Kebisingan Pada Alat Berat Wheel Loader Wa-350 Berdasarkan Perbandingan Jarak 50, 100, 150 Cm Dan Kapasitas." SPROCKET JOURNAL OF MECHANICAL ENGINEERING 5, no. 2 (February 27, 2024): 95–110. http://dx.doi.org/10.36655/sprocket.v5i2.1396.
Повний текст джерелаАнотація:
Wheel loader is a tool that facilitates work by using hydraulic energy. Wheel loader testing is carried out by looking for noise data arising in the combustion chamber. There are several stages that must be done, namely the first step is to prepare a sound level meter as a noise detection device for heavy equipment, wheel loader, then take measurements with several variations in the distance between the combustion chamber and the sound level meter. In the next step we can find out the noise level read at the sound level meter with ideal, medium, and maximum rotation on the WA-350 wheel loader. So that the Noise Threshold Value according to Permenaker No. per-51 / MEN / 1999, ACGIH, 2008 and SNI 16-7063-2004 is 85 dB. So the noise produced by the Wheel Loader above the NAB Permenaker 104.7dB can cause tingling, unwell, hearing saturation, stomach pain, and circulatory problems. It is recommended that workers are required to use earmuffs or ear muffs.
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Moch Yunus. "Pemikiran Politik Imam Al-Mawardi tentang Penganggkatan Imam (Khalifah)." HUMANISTIKA : Jurnal Keislaman 6, no. 2 (July 5, 2020): 191–209. http://dx.doi.org/10.55210/humanistika.v6i2.368.
Повний текст джерелаАнотація:
al-Mawardi layak dikatakan sebagai politikus yang ulung, dikarenakan hidup di zaman dua khalifah (al-Qadir Billah (381-422 H) dan al-Qa’imu Billah (422-467 H), tepatnya tahun 370-450 H. }}Selain itu kariernya sebagai politikus cukup bagus,khususnya pada masa al-Qadir yaitu menjadi hakim agung (qâdi al-qudât), penasehat raja atau khali>fah di bidang agama (hukum Islam) dan pemerintahan. Karena kepandaian diplomasinya pula ia ditunjuk sebagai mediator perundingan antara pemerintah Bani Abbas dengan Buwaihi yang sudah menguasai politik pada waktu itu. Al-Mawardi berhasil melakukan misinya dengan memuaskan kedua belah pihak. Kecerdasannya dalam dunia politik, beliau torehkan dalam bentuk buku, yang meliputi:al-Ah}ka>m al-Sult}a>niyah, Siya>sat al-Wiza>rati wa Siya>sat al-Maliki, Tas}il al-Nad}ari wa Ta’jil al-D}afari fi Akhla>qi al-Maliki, Siya>sat al-Maliki, Nas}ihat al-Muluk. Kitab-kitabnya menjadi rujukan bagi ulama pada masanya hingga sekarang. Hal yang terpenting dalam pemilihan pemimpin adalah adanya pemimpin dan yang dipimpin sesuai dengan criteria yang ideal. Setelah keduanya sudah ada, maka proses pemilihan pemimpin diserahkan ke ahl –h}all wa al-‘aqd untuk dibaiat dengan mempertimbangkan pilihan imam sebelumnya. Dalam proses pemilihan itu pula, calon imam diberi kesempatan untuk menjelaskan kontrak sosial selama dia menjabat sebagai imam. Itu sebagai pertimbangan terpilih/tidaknya dia sebagai imam. Apabila dalam perjalanan si imam tidak amanah dalam menjalankan amanahnya, maka rakyat boleh melakukan pembangkangan atau lebih ekstrim pemakzulan.
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Sankaran, Santosh, James Nguyen, Tara Jennings, Vinay Kumar, Michael B. Lilly, Michael M. Ittmann, Patricia Castro, et al. "Abstract 2148: Tumor-microenvironment from African-American prostate cancer exhibit methylation of multiple immune modulators." Cancer Research 84, no. 6_Supplement (March 22, 2024): 2148. http://dx.doi.org/10.1158/1538-7445.am2024-2148.
Повний текст джерелаАнотація:
Abstract Background: Non-Hispanic Black American patients (BA) with prostate cancer (PCa) tend to fare worse than their Non-Hispanic White American counterparts (WA), even with consideration of socioeconomic disparities. Clinically, BA face diagnosis at younger age with worse clinical outcomes. Stromal cells adjacent to the tumor, including carcinoma-associated fibroblasts (CAFs), play a critical role in tumorigenesis of PCa. Dysfunction in the tumor microenvironment play a crucial role in mediating prostate cancer tumorigenesis and is emerging as a key target for cancer therapy in solid tumors. Methods: To investigate whether DNA methylation varies in tumor adjacent stroma (TAS) among PCa patients with different geographical ancestries, areas immediate adjacent to tumor (i.e., less than 1mm) removed for methylation analysis. A complete genome-wide DNA methylation of PCa stroma using 17 BA and 15 WA patients who had radical prostatectomy was carried out. Methyl-Captured (mCap) sequencing data was generated for TAS of prostate cancer FFPE tissues. Methylated sites were identified with the MACS2 callpeak function using a band width of 300 bp and a false discovery rate of q < 0.05. A consensus peak set was derived from the aligned reads of BA and WA prostate cancer stroma samples that were sequenced. Pathway analysis was performed using Ingenuity Pathway Analysis (IPA) tools. CAFs from primary tumors of BA and WA was prepared by tissue culture and treated with demethylating agent (i.e., 5-Azacytidine) for 24 hours followed by maintenance of the cells in drug-free medium for 7-10 days and subjected to mCap sequencing. Results: We found racial disparities in genome-wide DNA methylation in TAS between the two populations in which BA PCa patients had significantly increased in global DNA methylation as compared to their WA counterpart (p value < 0.001). Hypomethylation occurred in CAFs from BA patients treated with 5-Azacytidine. We identified 1041 methylated sites corresponding to 409 unique genes that were differentially methylated in BA vs WA (p value < 0.05). Pathway analysis identified significant association between methylated genes in BA TAS and immune response pathways including IL-13, JACK/STAT, T cell receptors, NF-KB, and PD-1, PDL1 cancer immunotherapy. Evaluation of the methylome profile between patients based on the post-prostatectomy resection margins, negative (R0) vs positive (R1), showed that R0 resections had significantly greater (p value < 0.001) methylation than R1 resections. Further analysis identified 984 sites corresponding to 373 differentially methylated, unique genes (p value < 0.05). Conclusion: Tumor-adjacent stroma of BA prostate cancer patients has a distinct methylome as compared to WA patients. Differences in immune response pathways suggests a distinct immune response in TAS in men of different races. Citation Format: Santosh Sankaran, James Nguyen, Tara Jennings, Vinay Kumar, Michael B. Lilly, Michael M. Ittmann, Patricia Castro, Liankun Song, Thomas Keane, Weiping Chu, Xiaolin Zi, Omid Yazdanpanah, Arash Rezazadeh Kalebasty, Farah Rahmatpanah. Tumor-microenvironment from African-American prostate cancer exhibit methylation of multiple immune modulators [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2148.
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Tonello, Marcela Sandra, Maria Virginia Mancini, and Heikki Seppä. "Quantitative reconstruction of Holocene precipitation changes in southern Patagonia." Quaternary Research 72, no. 3 (November 2009): 410–20. http://dx.doi.org/10.1016/j.yqres.2009.06.011.
Повний текст джерелаАнотація:
AbstractHolocene variations in annual precipitation (Pann) were reconstructed from pollen data from southern Argentinian Patagonia using a transfer function developed based on a weighted-averaging partial least squares (WA-PLS) regression. The pollen–climate calibration model consisted of 112 surface soil samples and 59 pollen types from the main vegetation units, and modern precipitation values obtained from a global climate database. The performance (r2 = 0.517; RMSEP = 126 mm) of the model was comparable or slightly lower than in other comparable pollen–climate models. Fossil pollen data were obtained from a sediment core from Cerro Frias site (50°24'S, 72°42'W) located at the forest-steppe ecotone. Reconstructed Pann values of about 200 mm suggest dry conditions during the Pleistocene–Holocene transition (12,500–10,500 cal yr BP). Pann values were about 300–350 mm from 10,500 to 8000 cal yr BP and increased to 400–500 mm between 8000 and 1000 cal yr BP. An abrupt decrease in Pann at about 1000 cal yr BP was associated with a Nothofagus decline. The reconstructed Pann suggests a weakening and southward shift of the westerlies during the early Holocene and intensification, with no major latitudinal shifts, during the mid-Holocene at high latitudes in southern Patagonia.
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Lim, Weng Marc. "Antecedents and consequences of e-shopping: an integrated model." Internet Research 25, no. 2 (April 7, 2015): 184–217. http://dx.doi.org/10.1108/intr-11-2013-0247.
Повний текст джерелаАнотація:
Purpose – The purpose of this paper is to present an integrated information systems–consumer behavior (IS-CB) model for e-shopping to examine the antecedents and consequences of e-shopping and usage behavior. Design/methodology/approach – The study tests 320 usable responses collected from e-shoppers against the integrated model using structural equation modeling. Findings – The main research results support the use of antecedents of e-shopping acceptance and usage by drawing from unified knowledge of IS and CB underpinnings. The findings show the significance of perceived value, social factors, perceived ease of use, perceived usefulness, entertainment gratification (EG), web irritation (WI), emotional state, and web atmospherics (WA) in the process of e-shopping. Practical implications – The results suggest that e-retailers should establish positive perceived value in consumers’ minds and uphold trust to foster favorable attitudes and intentions toward e-shopping and actual e-shopping purchase. Proper and good construction of WA can lead to useful and easy-to-use e-shopping sites, EG, and minimization of WI. Capitalizing on online social influences also would be an advantage. Originality/value – This paper bridges a gap in the studies of IS and CB, contributing to a more comprehensive understanding of the influence of IS and CB antecedents on acceptance and usage of e-shopping.
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Ismael AL-TEL, Dr Othman. "SAQIFAT BANI SA`IDAH CONFERENCE A CRITICAL ANALYTICAL STUDY OF EARLY ISLAMIC NARRATIVES." RIMAK International Journal of Humanities and Social Sciences 06, no. 02 (March 1, 2024): 150–65. http://dx.doi.org/10.47832/2717-8293.28.9.
Повний текст джерелаАнотація:
The study deals with the narratives al-Saqifa conference according to six historians lived in the third and fourth centuries A.H/ ninth and tenth A.D, they are: Ibn Ishaq, Muhammad ibn Ishaq ibn Yasar (d. 151 A.H/ 768 A.D), "Al-Sira Al-Nabawiya", Ibn Sa`ed, Muhammad ibn Manee` al-Zuhri (died 230 A.H/ 845 A.D), "Al-Ṭabaqat al-Kubra", ,Al-Balaḏeri, Ahmad ibn Jaber (died: 279A.H/892 A.D), "Ansab al-’Ashraf", Al-Ya‘qubi, Ahmad ibn Abi Ya‘qub in wahab ibn Wadih (died: 284 A.H/ 897 A.D), "Tarikh al-Ya‘qubi", the book of "Al-Imama wa Al-Siyas", to anonymous author (from the middle of the third century A.H), Al-Ṭabari, Abu Ja‘far Muḥammad ibn Jarir (died: 310 A.H/923 A.D); "Tarikh al-Rusul wa-al-Muluk. The five sources of the study were chosen because they are considered among the early and important of Islamic historical sources, and their date back to different periods. In addition, they are distributed between different Muslims sects, such as Suni and Shite. The study adopts the historical method, by presenting the narratives of these historians about al-Saqifa conference and studing and analyzing their narratives and dimensions they contain which enable to know their points of view
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Gerritse, RG. "Mobility of phosphate from waste water in calcareous sands of Rottnest Island (WA)." Soil Research 31, no. 3 (1993): 235. http://dx.doi.org/10.1071/sr9930235.
Повний текст джерелаАнотація:
Natural levels of inorganic phosphate in soils of Rottnest Island are quite high: about 300 mg/kg as P (or about 4 t of P per ha per meter depth of soil). In comparison, the production of phosphorus in wastewater from sewage, treated on Rottnest Island, amounts to approximately 2 t per year. The phosphate, occurring in the soil naturally, is mainly in mineral form and not very soluble. Solution concentrations in the soils are less than 0.001 mg/L P-PO4 (at pH values of 8.5-8.9). Conditions in the calcareous soils of Rottnest Island are favourable for precipitation of phosphate as calcium phosphates. Theoretically >>99% of phosphate in wastewater from treated sewage can be stored indefinitely as hydroxy-, fluoro- and chloro-apatites. In practice, however, application of wastewater to these soils will result in a (kinetically defined) finite concentration of phosphate to move through the soil slowly as a sharp front. The effective width of the frontal zone was taken to be equal to the longitudinal hydrodynamic dispersivity. Mobilities, relative to water, of fronts resulting from step increases of phosphate in soils were then calculated with an experimentally obtained, time-dependent, adsorption equation and the average residence time of phosphate in the frontal zone. Calculated mobilities were verified experimentally by leaching phosphate through small columns of soil at different concentrations of phosphate and rates of infiltration. For concentrations in wastewater between 10 and 15 mg/L P-PO4, mobilities of phosphate, relative to water, in soils of Rottnest Island are less than 2% for expected infiltration rates of wastewater between 0.5 and 1 cm/day.
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Wang, Yijun, Jelle Kaastra, Missagh Mehdipour, Junjie Mao, Elisa Costantini, Gerard A. Kriss, Ciro Pinto, et al. "Transient obscuration event captured in NGC 3227." Astronomy & Astrophysics 657 (January 2022): A77. http://dx.doi.org/10.1051/0004-6361/202141599.
Повний текст джерелаАнотація:
The relationship between warm absorber (WA) outflows of active galactic nuclei and nuclear obscuration activities caused by optically thick clouds (obscurers) crossing the line of sight is still unclear. NGC 3227 is a suitable target for studying the properties of both WAs and obscurers because it matches the following selection criteria: WAs in both ultraviolet (UV) and X-rays, suitably variable, bright in UV and X-rays, and adequate archival spectra for making comparisons with the obscured spectra. In the aim of investigating WAs and obscurers of NGC 3227 in detail, we used a broadband spectral-energy-distribution model that is built in findings of the first paper in our series together with the photoionization code of SPEX software to fit the archival observational data taken by XMM-Newton and NuSTAR in 2006 and 2016. Using unobscured observations, we find four WA components with different ionization states (log ξ [erg cm s−1] ∼ −1.0, 2.0, 2.5, 3.0). The highest-ionization WA component has a much higher hydrogen column density (∼1022 cm−2) than the other three components (∼1021 cm−2). The outflow velocities of these WAs range from 100 to 1300 km s−1, and show a positive correlation with the ionization parameter. These WA components are estimated to be distributed from the outer region of the broad line region (BLR) to the narrow line region. It is worth noting that we find an X-ray obscuration event in the beginning of the 2006 observation, which was missed by previous studies. We find that it can be explained by a single obscurer component. We also study the previously published obscuration event captured in one observation in 2016, which needs two obscurer components to fit the spectrum. A high-ionization obscurer component (log ξ ∼ 2.80; covering factor Cf ∼ 30%) only appears in the 2016 observation, which has a high column density (∼1023 cm−2). A low-ionization obscurer component (log ξ ∼ 1.0 − 1.9; Cf ∼ 20%−50%) exists in both 2006 and 2016 observations, which has a lower column density (∼1022 cm−2). These obscurer components are estimated to reside within the BLR by their crossing time of transverse motions. The obscurers of NGC 3227 are closer to the center and have larger number densities than the WAs, which indicate that the WAs and obscurers might have different origins.
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Husna, Melya, Hesi Eka Puteri, and Winarno Winarno. "Determinan Sustainabilitas Lembaga Keuangan Mikro Syari’ah dan Upaya Penanggulangan Kemiskinan di Kabupaten Agam." EKONOMIKA SYARIAH : Journal of Economic Studies 3, no. 2 (December 17, 2019): 61. http://dx.doi.org/10.30983/es.v3i2.2556.
Повний текст джерелаАнотація:
<p class="abstrak" align="center"> </p><p class="abstrak"><em>This study aims to analyze the determinants of the sustainability of Islamic microfinance institutions and efforts to reduce poverty in Agam district. Islamic microfinance institutions in this study are limited to Baitul Maal wa Tamwil in Agam Regency with a sample of 31 BMTs that existed until 2019. The method used is the mix method. Quantitative analysis uses Smart PLS 3.0 software as a data processing tool. Qualitative analysis uses interviews as a data collection tool. The results showed that management, human resources and culture were determinants of BMT sustainability in Agam District. This study also provides an analysis that BMT is an instrument that can be used in poverty alleviation in Agam District.</em></p><p class="abstrak"> </p><p class="abstrak">Penelitian ini bertujuan untuk menganalisis faktor-faktor penentu sustainabilitas (keberlanjutan) lembaga keuangan mikro syariah dan upaya dalam penanggulangan kemiskinan di Kabupaten Agam. Lembaga Keuangan Mikro Syariah dalam penelitian ini dibatasi pada <em>Baitul Maal wa Tamwil </em>(BMT)<em> </em>yang ada di Kabupaten Agam dengan sampel sebayak 31 BMT yang ada sampai tahun 2019. Metode yang digunakan adalah <em>mix method</em>. Analisis kuantitatif mengunakan <em>software Smart PLS 3.0</em> sebagai alat pengolahan data. Analisis kualitatif menggunakan wawancara sebagai alat pengumpulan data. Hasil penelitian menunjukkan bahwa Manajemen, SDM dan Budaya merupakan faktor penentu sustainabilitas BMT di Kabupaten Agam. Penelitian ini juga menyatakan bahwa BMT merupakan salah instrumen yang dapat digunakan dalam hal penanggulangan kemiskinan di Kabupaten Agam.</p>
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Nossent, J., D. Preen, H. Keen, W. Raymond, and C. Inderjeeth. "POS0084 SEPTIC ARTHRITIS IN CHILDREN. A LONGITUDINAL POPULATION-BASED STUDY IN WESTERN AUSTRALIA." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 250.2–250. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2269.
Повний текст джерелаАнотація:
Background:The incidence of Septic arthritis (SA) in adults is rising, but few data are available for children (1). SA symptomatology in young children is often atypical and delayed diagnosis can cause significant morbidity.Objectives:To describe the incidence, risk factors and long-term outcomes in children hospitalised with septic arthritis (SA) in Western Australia (WA).Methods:We extracted population-based longitudinally linked administrative health data for patients under 16 years with a first inpatient primary or secondary code of 711.xx (ICD9-CM) and M00.xx (ICD10-AM) in WA for the study period 1990-2010 (to allow a minimum 5 year followup). We report annual incidence rates per 100.000 (AIR), prior conditions during lookback (median 15 months, IQR 5-45) as well as joint and other comorbidities including Charlson comorbidity index (CCI) and standardised mortality rates (SMR) during a median follow-up of 10 years. Age and gender speficic population and mortality rate data were obtained from the Australian Bureau of Statistics.Results:A total of 891 patients (62% male, median age 6.4 (IQR 1.9-10.6) years with 34% <3 years of age) had a first admission for SA. AIR was 9.85 (CI 4.79-14.41) overall with higher rates in males (11.9 vs 7, p<0.01) and no apparent period (Figure 1) or seasonal variation. Knees (43.9%), hips (34.6%), and ankles (13.3%) were most frequently affected with Staphylococci (49%) the predominant organism in patients with positive cultures (41.5%). Prior infections (40.4%) and respiratory disease (7 %) were the main preexisting morbidities. Mean hospital stay was 5.78 (± 6.4) days with ICU admission required in 1.9%, while 30-day readmittance rate was 10.4%. During follow-up 25 patients (3%) had recurrent/persistent osteomyelitis, nine patients were diagnosed with osteoarthrosis (1.1%) and five patients (0.6%) underwent joint replacement. More female patients developed new comorbidity (CCI>0, 34.6 vs 27.2%, p=0.02) including diabetes (4.2% vs 0%, p=0.001), cardiovascular events (4.2 vs 1.4%, p=0.002) and chronic arthritis (1% vs 0, p=0.05). While the crude mortality rate was low (0.3%) SMR was significantly increased for female patients (10.52, CI 1.59-41.6).Conclusion:The statewide incidence of septic arthritis in children in WA is similar to a recent report (1) and did not change over a 20-year period. In this large population based study, subsequent bone/joint disease occured in 4.6 %, while a third of patients developed other comorbidity before the age of 18. Such (subclinical) comorbidity may thus be a contributing factor to SA development and to the increased mortality risk in female SA patients.References:[1]Cohen E, Katz T, Rahamim E, Bulkowstein S, Weisel Y, Leibovitz R, Fruchtman Y, Leibovitz E. Septic arthritis in children: Updated epidemiologic, microbiologic, clinical and therapeutic correlations. Pediatr Neonatol. 2020 Jun;61(3):325-330. doi: 10.1016/j.pedneo.2020.02.006Figure 1.Annual incidence of septic arthritis per 100,000 population <16 years in Western Australia over period 1990-2010 by gender.Acknowledgements:The authors wish to thank the Arthritis Foundation of WA for their support and would like to acknowledge the support of the Western Australian Data Linkage Branch, the Western Australian Department of Health, and the data custodians of, the Hospital and Morbidity Data Collection, the Emergency Department Data Collection the WA Cancer Register and the WA Death Register for their assistance with data collection.Disclosure of Interests:None declared.
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Kobrinsky, Nathan L., Diane E. Sjolander, Mary S. Cheang, Ralph Levitt, and Preston D. Steen. "Granulocyte-Macrophage Colony-Stimulating Factor Treatment Before Doxorubicin and Cyclophosphamide Chemotherapy Priming in Women With Early-Stage Breast Cancer." Journal of Clinical Oncology 17, no. 11 (November 1999): 3426–30. http://dx.doi.org/10.1200/jco.1999.17.11.3426.
Повний текст джерелаАнотація:
PURPOSE: To determine if inhibition of stem-cell activity induced by granulocyte-macrophage colony-stimulating factor ([GM-CSF]; Sargramostim; Immunex Corporation, Seattle, WA) withdrawal or priming protects hematopoietic stem cells from the cytotoxic effects of adjuvant chemotherapy for early-stage breast cancer. PATIENTS AND METHODS: Serial blood counts were performed in 20 women with early-stage breast cancer receiving four courses of cyclophosphamide and doxorubicin chemotherapy. By a double-blind, placebo-controlled, balanced randomization, subjects received GM-CSF priming on days 5 to 1 for courses 1 and 3 or courses 2 and 4. RESULTS: Compared with before priming, after priming the times to neutrophil nadir (12.8 ± 2.5 days v 14.8 ± 1.5 days, respectively; P = .0001) and platelet nadir (mean ± SD, 10.1 ± 1.9 days v 11.1 ± 2.2 days, P < .05) were shorter, indicating a shift of cytotoxicity to later progenitors. The neutrophil nadir was similar with and without priming (mean ± SD, 490 ± 310/μL v 550 ± 350/μL, respectively; P = .2); however, on day 16 the mean neutrophil count was higher (mean ± SD, 1030 ± 580/μL v 690 ± 370/μL, P = .004), and the proportion of patients with a neutrophil count less than 500/μL was lower after priming than before (six of 35 or 17.1% v 12 of 34 or 35.3%, respectively; P = .04). The platelet nadir was higher (mean ± SD, 166,000 ± 51,000/μL after priming v 151,000 ± 45,000/μL before priming, P = .007), and the duration of thrombocytopenia, ie, a platelet count less than 150,000/μL, was shorter (1.5 ± 2.1 days v 2.8 ± 2.9 days, P = .0025) after priming. Episodes of fever and neutropenia were not observed. CONCLUSIONS: GM-CSF priming from days 5 to 1 before doxorubicin and cyclophosphamide chemotherapy was associated with an earlier neutrophil and platelet nadir. On day 16, a higher mean neutrophil count and a lower proportion of patients with severe (< 500/μL) neutropenia were observed. Beneficial effects on the severity and duration of thrombocytopenia were also noted. These observations support the hypothesis that GM-CSF priming protects hematopoietic progenitors from the cytotoxic effects of chemotherapy.
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Nossent, J., W. Raymond, A. Kang, D. Wong, M. Ognjenovic, and A. Chakera. "The current role for clinical and renal histological findings as predictor for outcome in Australian patients with lupus nephritis." Lupus 27, no. 11 (August 9, 2018): 1838–46. http://dx.doi.org/10.1177/0961203318792361.
Повний текст джерелаАнотація:
Objectives To investigate the current demographic, clinical and histological characteristics of patients with lupus nephritis (LN) in Western Australia (WA) with regards to their predictive value for patient and renal outcome. Methods Retrospective study of adult systemic lupus erythematosus (SLE) patients with a first renal biopsy demonstrating LN between 1997 and 2017 at a metropolitan tertiary hospital in WA. Clinical data were collected at baseline and last follow-up with renal biopsy findings classified by International Society of Nephrology (ISN) criteria. Annual incidence rates (AIRs)/100,000, Kaplan–Meyer curves and Cox regression hazard ratio for independent predictors for patient and renal survival were applied. Results The AIR was 3.3, 3.1 and 0.4 for Asian ( n = 29), Indigenous Australian (IA) ( n = 11) and Caucasian ( n = 43) patients, respectively ( p < 0.01). There was no significant subgroup difference regarding ISN class (proliferative 66%, membranous 19%, mesangial 15%), levels of proteinuria (median PCR 300 mg/mmol) or frequency of raised creatinine (31%), anti-dsDNA antibody (89%) or hypocomplementaemia (88%). Treatment included corticosteroids (91%), cyclophosphamide (30%), mycophenolate (67%) and antihypertensive drugs (67%). Five- (81%) and 10-year (70%) survival was lower for IAs than for Caucasians and Asians (95% each at both time points) ( p = 0.016). Five- and 10-year renal survival (endpoint renal replacement therapy (RRT)) was 86% and 64% for IA vs 100% for Asian, 100% and 96% for Caucasian patients ( p = 0.02). IA background was the only independent predictor for poor patient survival and together with male gender also for renal survival. Only 25% of all patients remained free of any organ damage with non-renal damage observed in 53% of survivors. Conclusions LN incidence in WA was 0.75/100,000 with the lowest rate observed in Caucasians. While Asian patients have the same favourable outlook as Caucasians, the outcome is much bleaker for IA patients. Other clinical and histological findings did not predict outcomes, and importantly more than half of all surviving patients accrued non-renal damage.
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Schillinger, William F. "Ecology and Control of Russian Thistle (Salsola iberica) After Spring Wheat Harvest." Weed Science 55, no. 4 (August 2007): 381–85. http://dx.doi.org/10.1614/ws-06-189.
Повний текст джерелаАнотація:
Russian thistle is the most problematic broadleaf weed for spring-sown crops in the low-precipitation (< 340 mm yr−1) region of the inland Pacific Northwest of the United States. A 6-yr field experiment was conducted at Lind, WA, to evaluate three postharvest control strategies for Russian thistle in continuous annual spring wheat. Postharvest treatments were (1) tillage with low-disturbance overlapping undercutter V-blade sweeps; (2) paraquat + diuron at the labeled rate, which is widely used by farmers; and (3) an untreated check (letting Russian thistle grow unhindered). The undercutter V-sweep consistently killed all Russian thistle with essentially no residue burial, and no seed was produced. In contrast, the paraquat + diuron treatment halted Russian thistle dry biomass production, but plants continued to extract soil water and produce an average of 310 seeds m−2on the lower branches. In the check, Russian thistle produced an average of 700 kg ha−1postharvest dry biomass and 5,670 seeds m−2. The undercutter V-sweep treatment had significantly more water in the 180-cm soil profile at time of wheat harvest, after a killing frost in October, and in mid March as well as greater spring wheat grain yield compared with the herbicide and check treatments. Results show that postharvest tillage with an undercutter V-sweep consistently achieved 100% control, retained ample wheat residue on the surface to control erosion, and was by far the most effective treatment in this experiment.
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Tsypanov, Evgenii A., and Galina K. Lisovskaya. "Lisovskaya (Syktyvkar, Russia). Linguistic means of expressing comic in the works by Victor Savin." Finno-Ugric World 11, no. 3 (December 16, 2019): 294–300. http://dx.doi.org/10.15507/2076-2577.011.2019.03.294-300.
Повний текст джерелаАнотація:
Introduction. In Finno-Ugric Studies, as well as in Komi linguistics, the language of the founders of Komi literature, its features and artistic means of expression, its role in text formation are not well understood. Viktor Alekseevich Savin was not only the first Soviet Komi poet, playwright, composer and critic, but also one of the foundeers of the modern literary language. His works showed the great potential of his native language, laid down the tradition of creative writing, and became a role model for young poets and prose writers. The article analyzes the linguistic means of expressing the comic in his most popular works. Materials and methods. The object of the study was a series of works by Savin, his poems, essays, and several plays, which are traditionally referred to as anti-religious in literary criticism. The authors used traditional methods of semantic analysis of vocabulary, component, and contextual analysis. Results and Discussion. Not everything written by Savin is equally relevant and close to a modern reader, but many items of his poems, his dramas, and short stories are loved by readers and are still in demand. These are the anti-religious comedies “Rayin” (“In Paradise”), “Inastov lov” (“A Restless Soul”), “Wa Shyr” (“Water Rat”), and the poem “Arkirey” (“Bishop”). However, already in the post-perestroika years these works were not staged any longer at any of the state theaters of the Komi Republic. Conclusion. Satirical poems, comedies, short stories, and essays by Savin have been checked by the time, and remained in the Komi literature’s golden fund, loved by readers and spectators. In connection with the 130th anniversary of the birth of Victor Savin, it is necessary to raise the question of reprinting his works and staging his plays.