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Статті в журналах з теми "Voies aéro-digestives supérieures – Cancer – Génétique":
Flori, Nicolas, Hervé Chrostek, Laurent Bianchi, Éric Assenat, Anne Fallières, Arnaud Vaille, Corinne Bouteloup, and Pierre Senesse. "Prise en charge d’un patient atteint d’un cancer des voies aéro-digestives supérieures." Nutrition Clinique et Métabolisme 27, no. 3 (September 2013): 162–68. http://dx.doi.org/10.1016/j.nupar.2013.06.004.
Hans, Stéphane, Florian Scotte, Caroline Hoffman, Nicole Pelicier, Madeleine Ménard, Cécile Badoual, Stéphane Oudard, Martin Housset, and Daniel Brasnu. "Expérimentation du parcours personnalisé des patients atteints d’un cancer des voies aéro-digestives supérieures." Bulletin du Cancer 101, no. 10 (November 2014): 910–15. http://dx.doi.org/10.1684/bdc.2014.2040.
Pastourel, R., E. Dumousset, N. Saroul, T. Mom, Y. Boirie, L. Gilain, and L. Gilain. "Comparaison de différents marqueurs de dénutrition chez le patient atteint d’un cancer des voies aéro-digestives supérieures." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 131, no. 4 (October 2014): A66. http://dx.doi.org/10.1016/j.aforl.2014.07.178.
Pastourel, R., L. Gilain, V. Dupuch, T. Mom, Y. Boirie, and N. Saroul. "Évaluation prospective de la relation entre précarité, qualité de vie et état nutritionnel chez le patient atteint d’un cancer des voies aéro-digestives supérieures." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 131, no. 4 (October 2014): A27. http://dx.doi.org/10.1016/j.aforl.2014.07.078.
Thiam, A., A. Dièye, P. Ndongo, and M. Ndiaye. "C2: Endoscopie des voies aéro-digestives supérieures : Bilan de l’activité sur une période de deux ans (2018 – 2019) à la clinique Lamine Sine Diop du CHU de Fann." African Journal of Oncology 2, no. 1 Supplement (March 1, 2022): S3. http://dx.doi.org/10.54266/ajo.2.1s.c2.skkt73ds1b.
Gene, K., D. Luce, and C. Barul. "Le travail dans le bâtiment et les travaux publics (BTP) est-il associé au risque de cancer des voies aéro-digestives supérieures ? Résultats préliminaires de l’étude cas-témoins française, ICARE." Revue d'Épidémiologie et de Santé Publique 70 (August 2022): S212. http://dx.doi.org/10.1016/j.respe.2022.06.022.
Vansteene, D., M. Pons, P. Bachmann, and B. Raynard. "Évaluation des pratiques professionnelles : prise en charge nutritionnelle des patients atteints de cancer des voies aéro-digestives supérieures traités par radiothérapie ou radio-chimiothérapie dans un centre français de lutte contre le cancer." Nutrition Clinique et Métabolisme 33, no. 1 (March 2019): 51–52. http://dx.doi.org/10.1016/j.nupar.2019.01.313.
Pastourel, R., E. Dumousset, N. Saroul, T. Mom, L. Gilain, and Y. Boirie. "Évaluation d’un nouvel outil de mesure de la dénutrition chez le patient atteint d’un cancer des voies aéro-digestives supérieures : l’indice de masse musculaire sur coupe scannographique axiale passant par L3." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 131, no. 4 (October 2014): A67—A68. http://dx.doi.org/10.1016/j.aforl.2014.07.183.
Cuny, F., E. Babin, J. Lacau Saint Guily, B. Baujat, R. Bensadoun, A. Bozec, D. Chevalier, et al. "Recommandation de la SFORL sur l’organisation du parcours de soins en cancérologie des voies aéro-digestives supérieures (version courte). Prise en charge précoce des patients porteurs d’un cancer de la tête et du cou." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 132, no. 4 (September 2015): 191–95. http://dx.doi.org/10.1016/j.aforl.2015.06.001.
Randriamanovontsoa, NE, NRE Hasiniatsy, M. Razakanaivo, and F. Rafaramino. "Caractéristiques épidémio-cliniques des cancers des voies aéro- digestives supérieures au Service Oncologie du CHUA/JRA de 2008 à 2012." La Revue Médicale de Madagascar 5, no. 3 (2015). http://dx.doi.org/10.62606/rmmao00167.
Дисертації з теми "Voies aéro-digestives supérieures – Cancer – Génétique":
Redon, Richard. "Contribution au modèle génétique de progression tumorale des cancers des voies aéro-digestives supérieures : Application de la technologie des puces à ADN au criblage génomique des tumeurs." Université Louis Pasteur (Strasbourg) (1971-2008), 2002. http://www.theses.fr/2002STR13105.
Jehl, Aude. "Cavéoline-1 prédictive de la métastase et de la rechute locorégionale des cancers des voies aérodigestives supérieures." Thesis, Strasbourg, 2022. http://www.theses.fr/2022STRAJ070.
This translational research project on head and neck cancers has identified caveolin-1 (Cav1) as a prognostic biomarker for the evolution of a primary tumor of these cancers. Indeed, an overexpression of this protein favors a locoregional relapse whereas a deficiency of Cav1 engages the tumor towards a metastatic process. Moreover, we have highlighted the involvement of the Cav1 / EREG / YAP axis in the resistance to treatment (cetuximab and radiotherapy). Finally, we identified epiregulin (EREG) as the key protein in cetuximab resistance. Thus, a deficiency of EREG sensitizes cells to cetuximab by activation of ferroptosis and the association of this target therapy with the RSL3 molecule or metformin drastically restricts cell survival by accentuating this programmed cell death. These last results could be confirmed thanks to a complex 3D model recapitulating the intra- and inter-tumoral heterogeneity, namely the tumoroid model established from surgical parts of patients with head and neck cancer
Mourtada, Jana. "Mécanismes d’activation de la réponse immunitaire par DNp63 dans les cancers des voies aérodigestives supérieures HPV-positifs." Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAJ127.
HPV+ oropharyngeal tumors display both prognostic and molecular heterogeneity. Patients prognosis can be distinguished by the presence or absence of a molecular signature that depends on the ΔNp63 transcription factor. We demonstrated that ΔNp63 inhibits the migratory and invasive capabilities of HPV+ HNSCC cell lines and increases their sensitivity to platinum-based chemotherapy, implying its role in tumor progression. A functional analysis of ΔNp63 revealed its ability to stimulate the phagocytosis of cancer cells by macrophages in vitro. Consistently, a transcriptomic analysis of the same cellular model highlighted that ΔNp63 regulates the expression of secreted factors, including chemokines and interleukins, among which is the DKK3protein. Our findings indicate that DKK3 secretion by cancer cells activates the NF-κB pathway in macrophages, mimicking ΔNp63's effects on phagocytosis regulation. Induction of the NF-κB pathway by DKK3 in macrophages is mediated by its receptor CKAP4. Finally, our analyses suggest that ∆Np63 regulates the expression of factors involved in the inflammasome, as well as those of other cytokines such as TNFRSF11B, CCL26, CCL11, TIMP1 and TIMP2. Altogether, our results show that ΔNp63 plays a unique role in the prognosis of HPV+ patients by regulating secreted molecules involved in the recruitment and immune cell activation
Salavert, Marianne. "Les plasmocytomes des voies aéro-digestives supérieures : à propos de quatre observations." Montpellier 1, 1988. http://www.theses.fr/1988MON11282.
Barul, Christine. "Exposition professionnelle aux solvants et risque de cancer des voies aéro-digestives supérieures." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS588/document.
Background : The role of occupational exposure to solvents in the risk of head and neck cancer has been suggested in some studies but has been few investigated, despite their widespread use in the workplace. Objective: The objective of this thesis was to examine the associations between occupational exposure to solvents and the risk of head and neck cancer. Methods: This work is based on data from the ICARE study, a large population-based case-control study conducted in France between 2001 and 2007. The analysis was restricted to men and included 1,857 cases of squamous cell carcinoma of the oral cavity, pharynx and larynx and 2,780 controls. Detailed occupational lifetime as well as alcohol and tobacco consumptions were collected by questionnaires. Exposure to solvents was assessed by job exposure matrices and included five chlorinated solvents (perchloroethylene, trichloroethylene, methylene chloride, chloroform, carbon tetrachloride), five petroleum-based solvents (benzene; gasoline; diesel, fuels and kerosene; special petroleum products; white spirits) and five oxygenated solvents (ketones and esters; alcohols; diethyl ether; ethylene glycol; tetrahydrofuran). Odds-ratios adjusted for smoking, alcohol drinking and other potential confounders and 95% confidence intervals were estimated with logistic models. Results: No significant association was found between occupational exposure to chlorinated, petroleum-based and oxygenated solvents and the risk of head and neck cancer overall. In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to perchloroethylene. Non-significantly elevated risks of hypopharyngeal cancer were found in men exposed to high cumulative levels of methylene chloride, white spirits and tetrahydrofuran. An association between exposure to tetrahydrofuran and oral cavity cancer was also suggested. No other clear association was found for the other solvents under study, for any cancer site. Conclusion: Although positive associations were observed for several solvents, overall the results do not suggest a substantial role of exposure to solvents in head and neck cancer risk
Lallemant, Benjamin. "Etude de modifications transcriptionnelles dans les carcinomes des voies aéro-digestives supérieures." Montpellier 1, 2009. http://www.theses.fr/2009MON1T033.
Head and neck squamous cell carcinoma (HNSCC) prognosis is globally poor. The development of new tools for the management of this disease is urgent. Gene expression profiling is a promising biologiCai approach that has been extensively used in cancer research. Examples include elucidating the biological mechanisms involved in tumorigenesis and metastatic progression, identifying potential biological targets for the development of new drugs, identifying biological pathways involved in tumour resistance to chemotherapy or radiotherapy and improving tumour staging and patient outcome prediction. With gene expression profiling, it is possible to observe and quantify gene expression deregulation in tumour cells or their surrounding environment. Two technologies are currently used: DNA microarrays and RT-qPCR. Based on a comprehensive review of the literature and original researches this work presents an updated state of the art of the potential clinical applications of gene expression profiling in the field of HNSCC. In the study "Clinical relevance of nine transcriptiory!al molecular markers for the diagnosis of head and neck squamouscell carcinoma in tissue and saliva rinse" we found that ILIRN, MAL and 11MPI are prospective tumor diagnostic markers for HNSCC. :M1vfPl overexpression is the most promising marker, and its detection could help identify tumor cells in tissue or saliva. In the study "Reference gene selection for head and neck squamous cell carcinoma gene expression studies" we found that in HNSCC and/or normal mucosa, the four best normalizat!on genes were ALAS, GAPDH, RPS18 and SHAD and the most stable combination of two genes was GAPDH-SHAD. We recommend using KALPHA-TBP for the study of Tl-T2 tumors, RPL27 -SHAD for T3-T4 tumors, KALPHA-SHAD for NO tumors, and ALAS-TBP for N+ tumors
Hagege, Anaïs. "Nouvelles stratégies thérapeutiques dans les carcinomes épidermoïdes des voies aéro-digestives supérieures." Electronic Thesis or Diss., Université Côte d'Azur, 2022. http://www.theses.fr/2022COAZ6009.
Head and Neck squamous cell carcinomas represent the 5th most aggressive cancer in the world. Innate or acquired resistances result in local or distant relapses following reference treatments including surgery, chemotherapy with cisplatin, and radiation therapy. Unfortunately, relapses are fatal shortly.The goal of my thesis is therefore to discover new therapeutic targets and strategies relevant for patients in therapeutic deadlock.The CAL33 and CAL27 cell lines from squamous cell carcinomas of the tongue were used as models. I derived cells resistant to radiation therapy and / or cisplatin for the first time.My research project is based on the identification of several kinases: Plk1 (Polo-like kinase), c-MET and AXL, overexpressed in HSNCC tumors. They are overexpressed in tumors resistant to standard treatments and high expression is correlated with a poor vital prognosis. My work had two axes.1- Understanding the mechanisms leading to the overexpression of Plk12- Determining the relevance of the therapeutic targeting of Plk1, c-MET and AXL.For Part 1, I determined that the protein "Roundabout Guidance Receptor 2 (ROBO2)", a receptor involved in organogenesis and axonal guidance during development, is a key component in controlling Plk1 expression. Inhibition by hypermethylation or deletion of ROBO2 in HSNCC cancers, would promote the overexpression of Plk1. ROBO2 would therefore act as a tumor suppressor.For Part 2, I showed that onvansertib (targeting Plk1) and cabozantinib (targeting AXL and c-MET) decrease the proliferation and invasion of sensitive and treatment-resistant cells (cisplatin and radiotherapy) that I generated in the laboratory. These treatments induce the death of cancer cells with low toxicity on normal cells. Onvansertib and cabozantinib strongly reduce the growth and invasiveness of experimental HNSCC tumors in nude mice and zebrafish. These two inhibitors are effective on 3D sections from biopsies of patients treated at the Cancer Center of Nice (Centre Antoine Lacassagne). Onvansertib shows a gain in efficacy in combination with standard treatments. These combinations make it possible to reduce the doses and therefore the toxicities of each treatment while maintaining maximum effectiveness. Therefore, onvansertib and cabozantinib offer new perspectives for patients with therapeutic deadlock on treatment with cisplatin and radiotherapy
Bozec, Alexandre. "Apport préclinique aux thérapeutiques moléculaires ciblées dans les carcinomes épidermoïdes des voies aérodigestives supérieures." Aix-Marseille 2, 2007. http://www.theses.fr/2007AIX20664.
Lallmahamood, Nizaar. "Facteurs de retard de diagnostic et approche clinique dans la prise en charge des patients atteints des cancers des voies aéro-digestives supérieures." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC037.
Starting from the meetings with patients suffering from head and neck cancer, this research shows that this disease is much more complicated that we think. Cancers are diseases with a such complexity that do not allow us to think that it is a result of factors that leeds to this disease. We can assume for example that a head and neck cancer is due to a drug addiction or a precariousness, but those two factors are not the unique reason. A lecture of the 4 cases, will highlight the psychical and physical effects of such a disease and the way we take care of those patients
Delahaye-Sourdeix, Manon. "Moving beyond Genome-Wide Association Studies." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10238.
Genome-wide association (GWA) studies consist in testing up to one million (or more) single nucleotide polymorphisms (SNPs) for their association with cancer risk in thousands of individuals, without requiring any prior knowledge on the functional significance of these variants. These studies have been valuable for establishing etiological hypotheses and understanding the underlying genetic architecture of human diseases. However, most of the heritable factors of these traits remain unexplained. Part of this variation may come from rarer variants that are not targeted by current genotyping arrays or variants with moderate to low effects for which detection by current GWA studies is impractical. In this context and as illustrated in this thesis, GWA studies can now serve as starting points towards further discoveries, looking for new strategies to study both rarer variants and rarer diseases. We have specifically explored these approaches in the context of lung cancer, head and neck cancer and Hodgkin's lymphoma. The use of bioinformatics to combine recent GWA study results with other sources of information, the integration of different types of genomic data as well as the investigation of the interrelationship between germline and somatic alterations represent the main opportunities pursued in this thesis work
Книги з теми "Voies aéro-digestives supérieures – Cancer – Génétique":
Société française de carcinologie cervico-faciale. Congrès (19 1987). La Chimiothérapie dans les cancers des voies aéro-digestives supérieures. Paris: Masson, 1987.
Частини книг з теми "Voies aéro-digestives supérieures – Cancer – Génétique":
Babin, Emmanuel, and Guillaume Grandazzi. "12. Un système paradoxant ? Soignants et prise en charge des patients en cancérologie des voies aéro-digestives supérieures." In Le cancer : un regard sociologique, 184–99. La Découverte, 2018. http://dx.doi.org/10.3917/dec.norb.2018.01.0184.
Тези доповідей конференцій з теми "Voies aéro-digestives supérieures – Cancer – Génétique":
Hascoët, E., G. Valette, G. Le Toux, and S. Boisramé. "Critères d'éligibilité à la réhabilitation implantaire de patients ayant été traités pour un cancer des voies aéro-digestives supérieures : revue de la littérature." In 63ème Congrès de la SFCO, edited by S. Boisramé, S. Cousty, J. C. Deschaumes, V. Descroix, L. Devoize, P. Lesclous, C. Mauprivez, and T. Fortin. Les Ulis, France: EDP Sciences, 2015. http://dx.doi.org/10.1051/sfco/20156302009.