Дисертації з теми "Voice of Place"
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Percy-Smith, Barry. "Multiple childhood geographies : giving voice to young people's experience of place." Thesis, University of Northampton, 1999. http://nectar.northampton.ac.uk/2837/.
Повний текст джерелаGarrett, Stephen. "Unruly conversations with a health council, giving voice a place at the board table." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ59442.pdf.
Повний текст джерелаAnderson, Isobel. "My words trace a path : encounters with place through voice, performance and field recording." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695216.
Повний текст джерелаSkinner, Susan Margaret. "A history of the Cornish male voice choir : the relationship between music, place and culture." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/2894.
Повний текст джерелаWalker, Susan. "Finding a voice at the end of life : exploring preferred place of death in a hospice context." Thesis, Keele University, 2016. http://eprints.keele.ac.uk/2484/.
Повний текст джерелаCostilow, Cassie E. "Human Frequency Following Responses to Voice Pitch: Relative Contributions of the Fundamental Frequency and Its Harmonics." Ohio University Honors Tutorial College / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1275684866.
Повний текст джерелаThompson, Jennifer. "How we see this place: an intergenerational dialogue about conservation using Photo-Voice around Tiwai Island, Sierra Leone." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66925.
Повний текст джерелаVous pouvez exprimer une histoire différente par l'art. Que se passe-t-il quand on utilise l'enquête art-basée pour explorer la connaissance environnementale? Comment les connaissances alternatives artistiques peuvent valoriser et créer des connaissances alternatives qui auraient autrement été oubliées ou négligées? Les tendances holistiques et justice-orientées dans l'éducation environnementale plaident pour l'intégration de l'identité sociale dans les issues écologiques. Ce projet 'Photo-Voice' à caractère communautaire participatoire tient place dans les communautés rurales autour de 'Tiwai Island' au Sierra Leone. Le projet examine les biens environnementaux, communautaires et culturels afin d'être protégés pour les générations à venir. Les poèmes démontrent les nuances, les particularités et le contexte dynamique des aspets d'un endroit important à conserver pour ces communautés. L'étude appelle l'attention sur le processus continu de la reconstruction d'après-guerre au sein des communautés autour de 'Tiwai Island.' Elle soulève également des questions autour du rôle des structures physiques dans l'établissement, la négociation, la construction et le déconstruction de l'identité.
Kappes, Gabrielle A. F. "Fashioning a voice of her own : the poetics of place in Dorothy Wordsworth's poetry, narratives, and travel writing /." Norton, Mass. : Wheaton College, 2009. http://hdl.handle.net/10090/8393.
Повний текст джерелаSirniö, Janne. "Talande platser : Berättelser om platskommunikation." Thesis, Uppsala universitet, Institutionen för kulturantropologi och etnologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435116.
Повний текст джерелаLévêque, Yohana. "Le lien perception-production en voix chantée : place des représentations motrices." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM3089.
Повний текст джерелаA growing body of research reveals that action production and action perception interact. In particular, it has been shown that speech perception entails articulatory motor representations in the listener. In the present work, we investigate the perception of a singing voice, a stimulus that is not primarily linked to articulatory processes. Does listening to a singing voice induce activity in the motor system? Is this motor activity stronger for a voice than for a non-biological musical sound? Two behavioral tasks, a og virtual lesionfg{} paradigm using TMS, the study of brain oscillations with EEG and an fMRI experiment carried out during my PhD have shed some light on these questions. Our results show that the perception of a singing voice is indeed associated with sensorimotor activity in repetition and discrimination tasks. Interestingly, the poorer singers displayed the stronger motor resonance. The motor system could facilitate the processing of sound or the preparation of the vocal response by internal model generation when the acoustic processing is not effective enough. The set of studies presented here thus suggests that audiomotor interactions in human voice perception are modulated by two factors: the biological dimension of sound and the listeners' vocal expertise. These results suggest new perspectives on our understanding of the auditory-vocal loop in speech and of sound perception in general
Ralph, Thomas. "Constructing places of resistance and non-participatory identities in a secondary school undergoing radical change." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/23094.
Повний текст джерелаHenson, SΣndra Lee Allen. "To See Her Face, To Hear Her Voice: Profiling the Place of Women in Early Upper East Tennessee, 1773-1810." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1051.
Повний текст джерелаWright, Heather Lynn. "Supporting Rural Adolescent Voices in the Secondary English Language Arts Classroom." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/104465.
Повний текст джерелаDoctor of Philosophy
The purpose of this study was to use a sociocultural, anti-deficit, and dialogic rural theoretical framework to examine ways teachers can draw on the lived experiences of rural adolescent students in secondary English language arts classrooms as students make meaning with curriculum content. This study worked with the social constructs of rurality (Azano, 2011; Azano and Biddle, 2019; Corbett, 2007; Gruenewald, 2008), critical literacy (Freire, 1990, 2018; Gee, 1990), and learning-centered pedagogy (Fecho et al., 2021) to develop insights into ways that teachers navigate opportunities and challenges in contemporary rural schools. Participant criteria included being employed fulltime as an English language arts teacher at a rural secondary school, having taught for at least three years, and The study's three participants were rural North Carolina secondary English language arts teachers. Utilizing an adapted three-phase interview process, the study had three stages for each participant: (1) an intake interview, (2) three rounds per participant of co-planning, classroom observations, and post-observation conferences, and (3) a final interview. Thematic analysis (Maxwell, 2013) was used to analyze and code the data. Understandings were that participants, in their success and challenges of supporting rural student voices (1) supported student voice through instructional design, (2) attended to biases and seeking to dialogue within the classroom, and (3) utilized the lived experiences and literacies.
Alnaji, Ahmad. "Graffiti as Voice for Voiceless People : Critical Discourse Analysis of Sudanese Graffiti During Sudanese Revolution 2019." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-40747.
Повний текст джерелаWehby, Janet Been. "A Place of Worship: An Architecture Celebrating the Interconnectedness of God, Nature, and Man." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/33906.
Повний текст джерелаMaster of Architecture
Barwin, Lynn. "Places of Tradition, Places of Research: The Evaluation of Traditional Medicine Workshops Using Culturally and Locally Relevant Methods." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22870.
Повний текст джерелаLafford, Erin. "Forms of health in John Clare's poetics." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:c4171968-0d36-4c33-9536-dc75c4d02b4e.
Повний текст джерелаSelf, Stephen Daniel. "The si placet voice : an historical and analytical study /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267728619.
Повний текст джерелаBerenfeld, Alain. "Place de l'echocardiographie trans-oesophagienne dans les traumatismes thoraciques fermes." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13828.
Повний текст джерелаZedeño, M. Nieves, Alex K. Carroll, and Richard W. Stoffle. "Ancient Voices, Storied Places: Themes in Contemporary Indian History." Bureau of Applied Research in Anthropology, University of Arizona, 2006. http://hdl.handle.net/10150/277393.
Повний текст джерелаFOSSOUD, FREDERIC. "La polypose naso-sinusienne invalidante : place de l'ethmoidectomie par voie endo-nasale." Toulouse 3, 1991. http://www.theses.fr/1991TOU31518.
Повний текст джерелаPIETRI, PHILIPPE. "Hysteroplastie par voie abdominale : place actuelle dans le traitement des synechies uterines." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20256.
Повний текст джерелаPasquier, Claire Olivier Christophe. "Photosensibilisation par voie systémique place du pharmacien et rôle dans la photoprotection /." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/PHpasquier.pdf.
Повний текст джерелаBOYRIVENT, VIOLAINE. "Place de l'intubation lacrymo-nasale dans le traitement du larmoiement du nourrisson." Lyon 1, 1992. http://www.theses.fr/1992LYO1M256.
Повний текст джерелаWernesjö, Ulrika. "Conditional Belonging : Listening to Unaccompanied Young Refugees’ Voices." Doctoral thesis, Uppsala universitet, Sociologiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216417.
Повний текст джерелаBarbeau, Pascal. "Place de l'échocardiographie transœsophagienne dans un hôpital cardiologique : à propos de 1375 examens." Bordeaux 2, 1990. http://www.theses.fr/1990BOR23089.
Повний текст джерелаPOPPER, LAURENT. "Place actuelle des endoprotheses inserees par voie percutanee dans le traitement des stenoses de l'arbre biliaire." Toulouse 3, 1991. http://www.theses.fr/1991TOU31508.
Повний текст джерелаNUVOLI, DELIGNETTE ALEXANDRA. "Traitement de la lithiase des voies biliaires : place de la lithotritie par voie percutanee transhepatique." Lyon 1, 1990. http://www.theses.fr/1990LYO1M413.
Повний текст джерелаTaft, Kimberly E. "Absent Voices: Searching for Women and African Americans at Historic Stagville and Somerset Place Historic Sites." NCSU, 2010. http://www.lib.ncsu.edu/theses/available/etd-03272010-120644/.
Повний текст джерелаRadhi, Mazin. "La place de l'industrie dans la politique d'un pays en voie de développement : le cas de l'Irak." Montpellier 1, 1985. http://www.theses.fr/1985MON10049.
Повний текст джерелаKentheswaran, Vasuki. "Alliages réfractaires à forte entropie : comportement mécanique sous sollicitations complexes, mise en place d’une nouvelle voie d’élaboration." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCD052.
Повний текст джерелаFrom Japanese sabres to modern aircraft engines alloying elements have been used to enhance mechanical properties. Adding alloying elements to a main constituent enables to achieve a desired microstructure or to combine mechanical properties. High-entropy alloys, namely multicomponent metallic alloys, break with the past traditional approach since they contain several major elements in equiatomic or quasi-equiatomic proportions resulting in a single-phase disordered solid solution stabilised by its configurational entropy increased with the number of constituents, hence the name of such alloys. High-entropy alloys blaze a trail to new alloy design strategies and new type of metallic materials. The enthusiasm of the scientific community has been triggered by the oustanding mechanical properties of these alloys and particularly upon combining antagonist properties such as strength and ductility. Refractory high-entropy alloys are very promising materials for high temperature applications and need to be characterised upon various types of loading before considering them for potential applications. Process and characterisation are considered in the framework of this thesis. Under dynamic loading, the studied refractory high-entropy alloys with BCC structure exhibited either a thermal softening behaviour or a work-hardening behaviour. Fatigue endurance ratio has an oustanding level of 0.43 under four-point bending fatigue loading. The other aspect investigated in this study is the ability to process these alloys by powder metallurgy route and especially by Self-propagating High temperature Synthesis (SHS) and Spark Plasma Sintering (SPS)
Laurent, Olivier. "Reconstitution in vitro des fusions d'endosomes chez Dictyostelium discoideum : mécanismes moléculaires et place dans la voie endocytaire." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10287.
Повний текст джерелаJarysta, Amandine. "Rôle du gène fancg de la voie Fanconi dans la mise en place des cellules germinales primordiales." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS190/document.
Повний текст джерелаFanconi Anemia (FANC) is a genetic human disease, causing in patient a severe anemia, a higher risk to develop some cancers, and developmental anomalies including hypogonadism. The FANC pathway is involved in the replicative stress response and DNA repair, and has a potential role in the physiological regulation of fetal and adult stem cells. In mice models of the FANC pathway, the main phenotype is the sterility issue, associated to a developmental defect of the germ cell lineage, and is so a paradigm to study the pathology. Our study aimed to characterize the primordial germ cell (PGC) defect in fancg-/- mouse embryos. We showed a numerical defect of PGC early in the germ cell lineage development, as soon as 9.5–10.5 days post coitum (dpc). PGC show a mild defect of proliferation at 10.5–11.5 dpc, but no cell cycle arrest. This low proliferative defect can neither fully explain the drastic decrease of the PGC number, nor the mosaic profile of fetal gonads displaying cords without PGC at 13.5 dpc. In vitro and ex vivo studies of the migration behavior of fancg-/- PGC highlight abnormalities of the PGC’s motility, probably linked to abberant RAC1 GTPase activity. We also observed at 11.5 dpc a decrease of the cell number at the front of migration of the PGC population in 11.5 dpc fancg-/- embryos. Those motility defects could induce a migration delay, preventing a fraction of the fancg-/- PGC population to reach correctly the genital crests by 11.5 dpc. Hence, PGC depletion seems mainly linked to a migratory defect leading to increased cell death in PGC at 11.5 dpc, associated to an intrinsic proliferation defect of fancg-/- PGC
Boutaourout, El Houcine. "La place des pays en développement dans le système commercial multilatéral : (de la création du GATT à nos jours)." Paris 5, 2006. http://www.theses.fr/2006PA05D008.
Повний текст джерелаThe place of the developing countries in the multilateral commercial système evolved in several stages to arrive at the current situation. The birth of the multilateral commercial system started with the failure of the Charter of Havana and with the creation of GATT in 1947, whish was at its beginnings far from all concerns concerning the developing countries. The interests of the developing countries started with the adoption of Part IV, under the impluse of the UNCTAD, the SGP and then with the clause of enabling and graduation. Uruguay Round, was a major stage in this process which allowed the adoption of the Agreements of Marrakech in 1994 and the birth of OMC. The assessment of these agreements is mitigated, certain preserve the interest of the developing countries, other not. The rest was marked by the six ministerial Conferences of OMC and the launching of a new Cycle of negotiation which has difficulties to end
Mahasneh, Quhafah. "La place et le rôle des banques internationales privées dans l'endettement des pays en développement." Nice, 1991. http://www.theses.fr/1991NICE0014.
Повний текст джерелаThe purpose of our thesis is to study the role of the international banking system in the third world. In order to understand this relationship we have to pose the question of what went wrong during the last two decades. To pose this question presupposes that something is awry with banks' international financial intermediation. Therfore, in terms of the principles of banking we have to prove that there were problems with the way banks handled international lending. Our point of view is that borrover countries must regain their financial credibility in order to stimulate foreign capital
El, Khoury Alexis. "Conception et mise en place d'un procédé automatisé d'oxydation par voie humide en catalyse hétérogène (OVHC) : application au traitement d'effluents aqueux pollués au méthyltertiobutyléther (MTBE)." Paris 6, 2008. http://www.theses.fr/2008PA066146.
Повний текст джерелаThe identification of highly refractory and non-biodegradable organic pollutants in wastewater, especially coming from the chemical and petrochemical industry, has challenged the conventional wastewater treatment such as incineration or biological abatement. There is a clear need to test and set-up emerging alternative technologies that can deal with highly concentrated and/or toxic non-biodegradable organic water pollutants. Among the novel water treatment processes, Wet Air Oxidation (WAO) is described as a destructive technology based upon the oxidation of organic and inorganic pollutants. The system uses molecular oxygen or air as a potential source of oxidant. Generally, the pollutant is not totally eliminated but partially converted, through a radical mechanism, to multiple intermediates of less toxicity. WAO either could be a non-catalytic process or could occur in the presence of homogeneous or heterogeneous catalysts. In this work, catalytic tests of WAO had been conducted using a supported catalyst of ruthenium and cerium over alumina in order to treat aqueous contaminated effluents. The major part of the work consists of the conception and control of the developed process. Regulation loops integrated within a set of sensor modules had been developed in order to control the gas flow, the reactor temperature and the liquid evacuation unit. The process supervision and monitoring had been achieved through the deployment of a SCADA software application compliant with the latest technical and esthetical specifications needed for the proper operation of the system. The graphical interface developed for this purpose monitors the major parts of the process. We have tested the process efficiency and performance through the destruction of Methyl ter-butyl ether (MTBE) dissolved in water. This compound, commonly added to gasoline as an octane enhancer, has been recognized as a groundwater pollutant. It is highly soluble in water and transports easily in ground and surface water. Some typical results are presented pointing out the most important parameters of the process and showing the behavior of the catalyst prepared at the laboratory. Almost, a total destruction (more than 99% of conversion rate) of the pollutant could be obtained at 200°C using 200 g of catalyst for an oxygen pressure of 16 bar. Under theses conditions, the oxidation of the pollutant yields to 10% of intermediates among which we have identified acetic acid, acetone and tertiarybutylalcohol (TBA)
DELIGNETTE, MARC. "Place de l'administration par voie intra-veineuse des prostaglandines e2 dans la maturation cervicale avant declenchement artificiel du travail." Lyon 1, 1991. http://www.theses.fr/1991LYO1M274.
Повний текст джерелаRaynaud, Myriam. "Place de la fibrinolyse intra-artérielle locale dans les accidents emboliques cérébraux per angiographiques : à propos de 3 cas." Bordeaux 2, 1991. http://www.theses.fr/1991BOR23023.
Повний текст джерелаElbaz, Alain. "La rhinoplastie par voie externe : à propos de 25 cas ; son intérêt dans la mise en place des greffons osseux." Nantes, 1991. http://www.theses.fr/1991NANT001M.
Повний текст джерелаBOURDES, VALERIE. "Place de la pharyngo-laryngo-oesophagectomie totale avec coloplastie dans les cancers des voies aerodigestives superieures : a propos de 57 cas de 1979 a 1992 a l'hopital de la croix-rousse." Lyon 1, 1993. http://www.theses.fr/1993LYO1M345.
Повний текст джерелаAksoy, Alp Eylem. "L’énonciation et la polyphonie dans l’œuvre d’Annie Ernaux." Thesis, Paris 4, 2012. http://www.theses.fr/2012PA040167.
Повний текст джерелаDespite her “flat” writing, the work of Annie Ernaux is an appropriate example of polyphonic writing in which different voices intervene. In order to reveal these different voices operating in her work we have undertaken a two-step analysis. First, we have analysed the enunciative instances in an attempt to make a distinction between the different actants of enunciation: senders (the enunciator, the locutor and the narrator) on the one hand and the receptors (the reader, the interlocutor and the narratee) on the other. Second, we have tried to put forth the different voices which can be heard by means of various forms of representation of the other’s parole in discourse in order to find the socio-cultural voices in her work. Such forms include the monological, dialogical and polyphonic forms, as well as various forms of reported speech, modalisation and the use of typographical icons
Malki, Safia. "Étude de la voie de signalisation prostaglandine D2/SOX9 dans la mise en place de la gonade mâle et dans l'ovaire pathologique." Montpellier 1, 2006. http://www.theses.fr/2006MON1T007.
Повний текст джерелаALVARADO, DUBOST CHRISTINE. "Le test a la dexamethasone par voie intraveineuse : interet dans les etats d'hypercortisolemie ; place dans la strategie diagnostique des syndromes de cushing." Lyon 1, 1989. http://www.theses.fr/1989LYO1M164.
Повний текст джерелаGarric, Laurence. "Rôle de la voie Nodal et du facteur de transcription pitx2c dans la mise en place des asymétries neurales dans l'épithalamus du poisson zèbre." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2312/.
Повний текст джерелаAlthough we consider ourselves to be symmetric along the left-right axis, our bodies display obvious asymmetries in structure and position of organs; our heart, for instance, is on the left side. Structural differences can also be found in the brain between the left and right hemispheres. These neuroanatomical asymmetries underlie functional and behavioural asymmetries, an example being language that is processed predominantly by the left hemisphere of our brain. Intriguingly, defects in brain lateralisation (the left or right orientation of asymmetries) have been recently correlated to neuropathological disorders such as schizophrenia, autism or neurodegenerative diseases. It seems, thus, that the correct establishment of neuroanatomical asymmetries is essential for a functional nervous system. In the zebrafish, Danio rerio, the establishment of left-right brain asymmetries is being addressed thanks to an asymmetrical brain structure, the epithalamus, which is located in the dorsal diencephalon. The epithalamus is made up of right and left habenular nuclei and the pineal complex, which contains the epiphysis (or pineal gland) and the parapineal gland. Parapineal location is an obvious neuroanatomical asymmetry because in 95% of cases it is located on the left side. Habenular nuclei also display asymmetries at neuroanatomic, cytoarchitectural and molecular levels which are conserved through vertebrate evolution. In the zebrafish, habenula asymmetries can be detected by differential expression of molecular markers, which define left and right nuclei identity. For instance, the kctd12. 1/leftover gene is preferentially expressed in the left nucleus. An asymmetry in habenular neurogenesis is also present: a pool of neurons appears earlier in the left habenular nuclei. A perfect correlation exists between the laterality (left or right orientation) of the parapineal migration and the distribution of the subdomains markers of habenulae. Studies have showed that this association is established through a stepwise series of interactions between the habenulae and parapineal during development. The TGF-ß/Nodal signaling pathway is a key factor in the establishment of epithalamic asymmetries: its activity in the left epithalamic territory biases the parapineal migration to the left and imposes asymmetry on neurogenesis. How Nodal impose laterality and asymmetries in the epithalamus remains unknown. My PhD project aims to identify Nodal targets genes that are involved in the establishment of asymmetry in the epithalamus. Pitx2c, a transcription factor, known to be a Nodal direct target gene, is a good candidate to bridge the gap between Nodal signaling, asymmetrical neurogenesis and laterality. Moreover, pitx2c has been shown to be involved in the positioning of organs relative to the midline and in asymmetrical organogenesis. In this context, my PhD work revealed the implication of pitx2c in building an asymmetrical epithalamus: pitx2c imposes asymmetric neurogenesis upon the impulsion of Nodal signalling. Unexpectedly, in parallel to its role in habenular neurogenesis, pitx2c also controls parapineal size which is crucial for correct acquisition of habenular neuronal identities
Revaud, Julien. "Les mécanismes impliqués dans la mise en place de la réponse immunitaire dans le cadre d'une administration par voie orale de vaccins vectorisés dérivés des adénovirus et effets des adjuvants." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC028.
Повний текст джерелаThe development of new vaccines for oral delivery is a desirable objective. Such vaccines would permit induction of immune responses at mucosal surfaces, which constitute the principal portais of entry for pathogens. Moreover, the oral delivery route, as compared with parenteral routes, would be safer and more practical for human usage, and would facilitate the vaccination of wildlife. At present, bowever, few vaccines are administered by die oral route. Of these, most are live attenuated vaccines, which present a certain risk. Non-replicative vectored vaccines derived from adenoviruses (rAd) tepresent an attractive alternative, as they are much safer than live attenuated vaccines and are capable of eliciting robust immune responses when delivered by parenteral routes. Nevertheless, their efficacy is diminished upon oral administration. The objectives of this study were three-fold : 1. To understand the different steps leading to induction of an immune response after oral delivery of rAd, 2. To explore different strategies for optimisation of such vaccines, 3. To determine the impact of adjuvants on the early steps involved in the induction of the immune response. After intragastric delivery of rAd, we measured transgene activity by bioluminescence and RT-qPCR, and showed that transgene expression was confined to the intestine, and restricted to delimited anatomical zones. Moreover, the distribution of bioluminescence and antigen-encoding transcripts was dissimilar in C57B1/6 and BALB/c mice. Finally, after intragastric delivery of rAd, we showed that adjuvants affect transgene expression and the ensuing immune response in both C57BL/6 and BALB/c mice
Faye, Ousmane. "Place d’un programme de lutte pour la prise en charge des Maladies de peau courantes dans les pays en voie de développement : expérience du Mali." Paris 6, 2008. http://www.theses.fr/2008PA066437.
Повний текст джерелаBejjany, Bouchra. "Oxydation par voie humide catalytique dans un réacteur à lit fixe gaz/liquide/solide de micropolluants organiques : mise en place du pilote : étude du catalyseur hétérogène." Paris 6, 2008. http://www.theses.fr/2008PA066013.
Повний текст джерелаThe Catalytic Wet Air Oxidation (CWAO) enables to remove toxic and/or non-biodegradable water pollutants such as methyl-tert-butylether (MTBE) or pesticides (phenylureas). This technique involves heating effluent at high temperatures (generally between 130 and 250°C) for a pressure domain ranging from 20 to 50 bar. This operation is conducted by using oxygen as an oxidant source and heterogeneous or homogeneous catalysts in order to convert the organic substance into a clean gas rejection and a biodegradable liquid. This work is initially based on the design and set up of an installation, which includes a tubular reactor made of stainless steel “Uranus B6” with a height of 700 mm and 70 mm internal diameter. It is set at the centre of a furnace resistance which is surrounded by a thick layer of insulating material. A high-pressure pump enables the introduction of the feed solution into the reactor. The oxygen is supplied by a high-pressure oxygen bottle and its flow rate is controlled by a flowmeter regulator. Two condensers, one cyclone, one regulator valve and one gas regulator ensure the separation of gas and liquid at the outlet of the reactor. The whole process is equipped with temperature and pressure sensors. The installation is also versatile, since it allows the preparation of the catalysts in the reactor itself. The second part of the study focuses on the development and the understanding of the preparation of the catalysts, composed by precious metals (Ruthenium and Cerium) supported on alumina. To demonstrate its efficiency and validate the installation, the catalyst Ru(0. 3%)/Ce(3%)-Al2O3 was used for the CWAO of methyl-tert-butyleter : the target molecule has been completely transformed and a reduction of more than 90% of the total organic carbon has been obtained. The fresh catalyst was characterized to check that it had the expected qualities. The used catalyst was also characterized to ensure that there were no significant changes. In a third step, the oxidation test of pesticide (isoproturon) has been performed with 50% of total organic carbon reduction. The treated effluent contains a lot of complex sub-products of reaction, whose identification could not be totally obtained by available means. However 90% of isoproturon has been transformed
Cordier-Picouet, Marie-Jeanne. "Organisation du systeme visuel et mise en place de la retinotopie tectale chez les amphibiens anoures." Paris 7, 1987. http://www.theses.fr/1987PA077104.
Повний текст джерелаDeschamps, Claire. "Etude de l'expression de la molécule de guidage éphrine-A5 dans le cerveau de souris au cours du développement : implication dans la mise en place de la voie mésostriatale." Poitiers, 2010. http://theses.edel.univ-poitiers.fr/2010/Deschamps-Claire/2010-Deschamps-Claire-These.pdf.
Повний текст джерелаNervous system activity depends on the establishment of a complex network of neuronal connections during embryonic and postnatal development. Understanding how these neural networks are established is a major focus of developmental neurobiology. Beyond its fundamental importance and given the significance of developmental mechanisms in the repair of adult neural circuits, elucidating the cellular and molecular mechanisms of axon guidance is necessary to understand the pathological conditions resulting from lesions or degenerative disorders of the nervous system. In the “Physiolopathologie des Troubles Neurodégénératifs et Adaptatifs” CNRS UMR 6187 laboratory, Prof. Afsaneh Gaillard managed to restore the nigrostriatal pathway in a mouse model of Parkinson's disease by grafting embryonic cells from the ventral midbrain in the substantia nigra. This work suggests that guidance cues are present in the adult tissue and may help to repair this pathway. In order to identify the molecular mechanisms that may be involved in this pathological condition, we investigated the mechanisms of guidance of dopaminergic neurons arising from the ventral midbrain during embryogenesis and connecting onto the striatum. Previous studies have suggested the involvement of ephrin-A5/EphA5 guidance molecules. However, no functional role neither expression of these proteins have been demonstrated up to now. We then showed, using immunohistochemistry, that ephrin-A5 protein is widely expressed in the central nervous system of mice during development. We more particularly detected ephrin-A5 in the vicinity of midbrain dopaminergic axons in the thalamus, the ventral forebrain and the striatum. Moreover, we showed, that a proportion of dopaminergic neurons express the receptor protein EphA5. In addition, we observed, in stripe assay, that the purified protein ephrin-A5 has a repellent effect on dopaminergic projections. Finally, the study of ephrin-A5 knock-out mouse embryos exhibited a decrease of tyrosine hydroxylase (used as marker for midbrain dopaminergic neurons) expression in the substantia nigra. Overall, this study suggests that ephrins-A and particularly ephrin-A5 may participate in the axon guidance of the dopaminergic mesostriatal pathway. This led us to propose a new model of axon guidance of dopaminergic mesostriatal connections in mice, in which the repulsive interaction between ephrin-A5, expressed in the microenvironnement of dopaminergic fibers, and EphA5, expressed on midbrain dopaminergic neurons, participate in the maintenance of the rostro-ventral trajectory of this pathway and in the topographic distribution of dopaminergic projections onto the striatum
Drougard, Anne. "Implication de l'apeline hypothalamique dans la transition entre un statut sain et un statut obèse/diabétique via la mise en place d'une voie péroxyde d'hydrogène hypothalamique-système nerveux autonome-foie." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2462/.
Повний текст джерелаHypothalamus is brain area involved in the control of glucose homeostasis. In response to many factors, hypothalamic activity will be modified, generating a change in activity of peripheral tissues via the autonomic nervous system. This loop of regulation generates an adjustment of glucose metabolism while its alteration leads to diseases such as diabetes type 2. During this thesis, we are interested in apelin, an adipokine also released by hypothalamic neurons. In the context of type 2 diabetes, apelin levels are increased in the blood and in the hypothalamus. Thus, we have demonstrated that the intracerebroventricular injection in normal mice, of high levels of apelin similar to that observed in the hypothalamus of obese and diabetic mice generates type 2 diabetes characteristics. This high level of apelin triggers hypothalamic Reactive Oxygen Species release such as H2O2 which over-activates sympathetic nervous system and targets liver increasing hepatic glucose production by glycogenolysis and gluconeogenesis. This hypothalamic H2O2 - autonomous nervous system - liver pathway is also found in a mouse model overexpressing apelin in the ventromedial nucleus. This pathway is always present and amplified in obese/diabetic mice demonstrating a lack of resistance to apelin. Thus this thesis brings to highlight that high levels of hypothalamic apelin are involved in the onset of type 2 diabetes