Дисертації з теми "Viral phenomenon"
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Aiewsakun, Pakorn. "Paleovirology : connecting recent and ancient viral evolution." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:370e0a28-ee67-441f-bce6-42ad4cdf9365.
Повний текст джерелаMuñoz, González Sara. "Immunopathogenesis of postnatal persistent infection generated by classical swine fever virus and its implication in the superinfection exclusion phenomenon." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/402652.
Повний текст джерелаClassical swine fever (CSF) is a highly contagious viral disease of domestic and wild pigs, included in the list of diseases notifiable to the World Organisation for Animal Health. The causative agent, CSF virus (CSFV), belongs to the Pestivirus genus, Flaviviridae family. Over the last century, great efforts have been directed towards the control and eradication of CSF, which today remains one of the most important diseases for animal health and in the pig industry worldwide. The circulation and intrinsic importance of low and moderate virulence strains in the endemic regions has been extensively described. Also, it has been shown the role of these type of viral strains in the generation of “the pregnant carrier sow syndrome” and persistent infection of piglets after trans-placental transmission. However, the mechanisms involved in this form of CSFV infections are not well known, and the existing studies date over 40 years ago. By contrast, the possible generation of viral persistence after postnatal infection of pigs is still a question to resolve. Against this background, this thesis has demonstrated the capacity of low and moderate virulence CSFV strains to produce postnatal persistent infection early after birth. To this end, newborn piglets were inoculated intranasally with CSFV. During six weeks, these piglets remained apparently healthy, although they were not able to generate detectable CSFV specific humoral nor cellular immune responses, maintaining high virus load in blood, organs and body secretions and excretions. In addition, it has been demonstrated the ineffectiveness of vaccination of six-week-old PI pigs, which were unable to elicit a detectable innate immune response, in terms of IFN type-I production, as well as acquired immune responses (i.e. IFN type-II and antibodies) following vaccination with a CSFV live attenuated vaccine (C-strain). The RNA of the vaccine could not be detected by a specific RT-qPCR in any of the samples analysed after vaccination, including the tonsil, suggesting a superinfection exclusion (SIE) phenomenon between the persistently infecting virus (primary infection) and the CSFV vaccine strain (secondary infection). Finally, six-week-old wild boars with CSFV persistent infection (first infection) were inoculated with a CSFV strain of high virulence (second infection or superinfection). PI wild boars did not develop clinical signs and showed a high load of the primary virus, causing persistence, in all samples analysed. In contrast, the secondary virus was not detected by either RT-qPCR or sequence analyses, thus demonstrating the phenomenon of superinfection exclusion (SIE). The lack of innate and acquired immune responses supported the previous studies from this thesis. In addition, in vitro assays with the PBMCs isolated ex vivo from persistently infected animals, a well-known target for the CSFV viral replication, further corroborated the CSFV SIE phenomenon. These findings demonstrated for the first time the ability of CSFV to induce SIE in vivo, in swine with persistent infection. The SIE phenomenon would likely explain the unresponsiveness of animals with persistent infection after vaccination with the live attenuated vaccine. Considering the existence of CSFV strains of low and moderate virulence and their ability to produce persistent infection forms, the results showed here may have potential epidemiological repercussions, especially in the endemic context. Importantly, persistently infected animals would remain unnoticed under serological control, given the absence of specific antibody response. This doctoral thesis has contributed to the understanding of the pathogenesis of CSFV infection, which depends not only on the virulence of the strain but also on the virus-host interaction, and opens new lines of research to understand the immunological bases and of viral pathogenesis for the generation of immunotolerance and persistence, hitherto unknown.
Karli, Chrysoula. "Socioeconomic factors that determine the phenomenon of migration in current Greece : a quantitative approach." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/61688/.
Повний текст джерелаCuevas, Sergio Alejandro Poveda. "Coarse-grained modeling with constant pH of the protein complexation phenomena." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-09062017-123617/.
Повний текст джерелаEstudos teóricos dos mecanismos moleculares responsáveis pela formação e estabilidade dos complexos de proteínas vêm ganhando importância devido às suas aplicações práticas no entendimento da base molecular de várias doenças, em engenharia de proteínas e biotecnologia. O objetivo deste projeto é analisar criticamente e aperfeiçoar um campo de força de granulidade grossa para interação proteína-proteína com base em propriedades termodinâmicas experimentais e aplicá-lo ao sistema proteico S100A4 relacionado com o câncer. Nosso objetivo final é gerar conhecimento para uma melhor compreensão dos mecanismos físicos responsáveis pelas associações de proteínas particulares em diferentes ambientes. Estudamos o papel das interações de curto e longo alcance na complexação de homo-associações. Além disso, analisamos a influência do pH e sua correlação com o mecanismo de regulação de cargas. Por meio de simulações Monte Carlo, analisamos e refinamos o parametro ajustável de Lennard-Jones para um modelo mesoscópico, usando dados experimentais do segundo virial para a lisozima, o quimotripsinogênio e a ribonuclease A. A partir disso, a proteína S100A3 foi usada para testar os novos parâmetros calibrados. Finalmente, foi avaliado o processo de dimerização das proteínas S100A4, observando o papel de algumas variáveis físico-químicas envolvidas na estabilidade termondinâmica de diferentes oligómeros.
Rennell, Dale. "A Genetic and Structural Analysis of P22 Lysozyme: A Thesis." eScholarship@UMMS, 1988. https://escholarship.umassmed.edu/gsbs_diss/238.
Повний текст джерелаFarrow, Melissa Ann. "Cytoplasmic Localization of HIV-1 Vif Is Necessary for Apobec3G Neutralization and Viral Replication: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/75.
Повний текст джерелаBrandano, Laura A. "Investigation of the C-Terminal Helix of HIV-1 Matrix: A Region Essential for Multiple Functions in the Viral Life Cycle: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/552.
Повний текст джерелаForman, Daron. "Viral Abrogation of Stem Cell Transplantation Tolerance Causes Graft Rejection and Host Death by Different Mechanisms: A Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/72.
Повний текст джерелаCai, Yufeng. "Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/448.
Повний текст джерелаVIANA, Normando José Queiroz. "Autoconsciência e padrões de atratividade no ciclo vital de homens e mulheres de orientação sexual homo e heteroafetiva." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17757.
Повний текст джерелаMade available in DSpace on 2016-08-26T15:37:10Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Tese NormandoJQViana_Biblioteca Central_UFPE (0).pdf certa.pdf: 2847669 bytes, checksum: 035b1ec1bda1217eaae08822bf17ca9e (MD5) Previous issue date: 2016-02-29
CNPq
Vem de longa data o interesse da ciência psicológica pela busca do autoconhecimento (James, 1890/1983). Neste contexto, os estudos oriundos do campo da autoconsciência, em especial com o advento da Teoria OSA (Duval & Wicklund, 1972), uma das primeiras teorias a considerar as discrepâncias entre o self e os padrões (Duval & Silva, 2001), têm reunido esforços no intuito de superar tamanha lacuna. Neste contexto, entusiasmado pela compreensão do self, em especial em sua vertente simbólica, bem como no instanciamento dos processos autoavaliativos por este operados, tramados à identificação da natureza dos padrões de atratividade e a forma como estes têm sido fenomenologicamente consciencizados no fluxo da experiência interna dos sujeitos, o presente estudo de tese objetiva identificar o que são os padrões de autoatratividade, qual sua dinâmica representacional no seio da experiência interna e o enlaçamento no processo autoavaliativo dos processos de atratividade autopercebida, autofocalização (autoconsciência situacional e disposicional), autoestima, bem estar (satisfação com a vida e felicidade), humor depressivo e religiosidade. Para o estudo em questão, foi recrutada uma amostra mista composta por 657 participantes (563 brasileiros e 94 portugueses), adolescentes, jovens, adultos e idosos, de ambos os sexos e orientações sexuais homossexual e heterossexual, residentes na Região Metropolitana do Recife e na cidade de Lisboa, Portugal. Os procedimentos relativos à coleta ocorreram em três etapas: a primeira com objetivo de levantar emicamente, por intermédio de procedimentos multimétodos, o campo semântico de autoatratividade (Estudo 1 – Qualitativo); a segunda, com base nos achados da etapa anterior, corresponde ao processo de elaboração e validação da Escala de Autoatratividade - EAA junto à pesquisa desta com o conjunto de instrumentos utilizados (Escala de Apreciação Corporal (EAC); Escala de Autoconsciência Situacional (EAS); Escala de Autoconsciência Disposicional (EAD); Escala de Autoestima de Rosenberg; Escala de Satisfação com a Vida; Escala de Felicidade Subjetiva; Escala CES-D (Rastreamento de depressão); Escala de Religiosidade Global (ERG) e Escala de religiosidade de item único, bem como o roteiro de entrevista Fenomenológico-Cognitiva dos Estados Autoconscientes – EFEA), a fim de permitir a identificação da multidimensionalidade da maquinaria psíquica atrelada ao construto atratividade dentre a amostra recrutada (Estudo 2 – Ex-post-facto) e a terceira etapa refere-se ao aprofundamento dos achados da etapa que a antecede, por intermédio da apresentação do gradiente fenomenal dos padrões de atratividade com base na identificação dos modos como estes são representados no fluxo da experiência dos participantes durante estado autoconsciente relacionado a autoatratividade (Estudo 3 – Fenomenal). A hipótese geral que dá sustentação ao estudo em questão considera que quanto mais autoconscientes e de modo reflexivo as pessoas são maior seria a capacidade que estas têm de minorar as influências que os padrões de atratividade exercem sobre os processos autoavaliativos, ocasionando prejuízos ao funcionamento psicológico saudável, além de que, os padrões, caso emerjam à consciência, no seio da experiência interna, se realizarão cognitivamente em elementos variados de natureza representacional, em especial na forma da fala interna e visualização interna. De modo específico, dentre o conjunto de hipóteses que dá sustenção ao referido estudo, destaca-se aquela que chama atenção ao papel moderador da religiosidade no possível impacto deletério que os padrões de atratividade ocasionam à vida das pessoas, haja vista, a importância e centralidade de tal dimensão para subjetividade humana. O modelo de análise de dados adotado no presente estudo de tese prezou, no tocante ao material quantitativo, pela investigação da dimensionalidade das escalas por via da metodologia das facetas (Guttman, 1968), com base nas Análises Multidimensionais não-métricas do tipo SSA (Similarity Structure Analysis, ver Guttman, 1968; Roazzi, 1995). Por sua vez, o material qualitativo foi submetido à análise de conteúdo (Estudo 1, Bardin, 1970) e a metodologia fenomenológica padrão (Estudo 2, Cott & Rock, 2008). Os principais achados do presente estudo de tese apontam que os padrões de autoatratividade e sua fenomenologia são representados cognitivamente na consciência por intermédio dos elementos da fala interna e das visualizações internas, associadas aos elementos do sentimento, bem como a consciência sensória. Não se encontrou, todavia, ocorrência de pensamento não simbolizado na análise fenomenal operada. A estrutura de tal padrão se organiza a partir de duas dimensões, uma física e outra não física, representadas pelos fatores: sensualidade, moralidade, apresentação pessoal, afetividade, inteligência, bom humor e asseio. Tais fatores quando correlacionados entre si, e junto as demais medidas utilizadas, apontam a presença de correlações estatisticamente significantes, em especial, no tocante às variáveis: Orientação sexual, no âmbito geral, os heterossexuais encontram-se mais próximos de um campo de afeto positivo, e os homossexuais nas cercanias do afeto negativo; Idade, os mais jovens, também situados num campo do afeto negativo, passando por um campo intermediário, onde há a presença de jovens adultos, findando com os participantes com idades entre 36 e 76 anos, cravados num campo de afeto positivo; Religiosidade, igualmente caracterizada por uma disposição polar, nas cercanias desta variável, os que se dizem religiosos, os heterossexuais e os adultos e idosos, e distanciando-se da religiosidade, localizados em plano antagônico, os que relatam não professar nenhuma fé, os adolescentes de 14 a 20 anos e os jovens homossexuais; e Nacionalidade, os portugueses mais próximos de um padrão de atratividade com base em princípios morais e os brasileiros simpáticos às variáveis sociodemográficas de natureza religiosa, inferindo que estas exercem influência sobre o instanciamento dos processos autofocalizadores, correlações estas cujos significados são corroborados pelos achados oriundos do estudo fenomenal. Tal estudo representa um esforço em dar visibilidade a uma temática pouco investigada na ciência psicológica, a natureza dos padrões de correção e o impacto destes nos processos autofocalizadores, em diálogo com uma perspectiva de mente dual, que contempla aspectos psicológicos e fenomenais da subjetividade e cognição humanas, a fim de contribuir com uma compreensão mais profunda sobre os aspectos cognitivos cruciais relacionados ao instanciamento de modos mais adaptados e, consequentemente, menos comprometedores da existência significativa e feliz.
The interest of the psychological science in the search for self-knowledge has come a long way (James, 1890/1983). In this context, studies from the self-awareness field, especially with the advent of the OSA Theory (Duval & Wicklund, 1972), one of the first to consider the discrepancies between the self and the patterns (Duval & Silva, 2001), have gathered efforts in order to overcome such gap. Within this framework, keen on understanding the self, especially in its symbolic aspect as well as in the instantiation of the self-assessment processes it operates, hatched in the identification of the nature of attractiveness patterns and how they have phenomenologically been made aware in the flow of the subjects‟ inner experience, this study aims to identify self-attractiveness patterns, their representational dynamics within the inner experience and the intertwining of the self-perceived attractiveness processes, of self-focusing (situational and dispositional self-awareness), self-esteem and well-being (life satisfaction and happiness), depressive mood and religiosity in the self-assessment process. For this study, a mixed sample of 657 participants (563 Brazilian and 94 Portuguese) was recruited, among whom were teenagers, adults and elderly people of both sexes, as well as homo and heterosexual orientations, living in the metropolitan area of Recife and in Lisbon, Portugal. The collecting-related procedures were carried out in three steps: the first one, to emically raise, through multimethod procedures, the semantic field of self-attractiveness (Study 1 - Qualitative); the second, based on the findings from the previous step, corresponds to the process of development and validation of the Self-attractiveness Scale – SAS, along with its survey with the set of instruments used (Body Assessment Scale - BAS); Situational Self-Awareness Scale (SSAE); Dispositional Self-Awareness Scale (DSAS); Rosenberg Self-Esteem Scale; Life Satisfaction Scale; Subjective Happiness Scale; CES-D Scale (Depression Tracking); Global Religiosity Scale (GRS) and Single-item Religiosity Scale, as well as the Self-Aware States Phenomenological-Cognitive interview script – SASPG), to enable the identification of the multidimensionality of the psychic machinery linked to the attractiveness construct within the recruited sample (Study 2 - Ex-post-facto). The third stage refers to deepening the findings of the previous one through the presentation of the phenomenal gradient of attractiveness patterns based on the identification of the ways they are represented in the flow of the participants‟ experience during the self-aware state related to self-attractiveness (Study 3 - Phenomenal). The general hypothesis that supports the present study considers that the more self-aware and reflective people are, the greater the capacity they have to reduce the influence attractiveness patterns have on self-assessment processes, which bring harm to healthy psychological functioning. Moreover, those patterns, should they emerge to awareness within the inner experience, will cognitively take place in a range of elements of representational nature, especially in the form of inner speech and inner visualization. In particular, among the set of assumptions that support this study, there is one that draws attention to the moderating role of religiosity in the possible deleterious impact attractiveness patterns cause to people's lives, given the importance and centrality of such dimension to human subjectivity. With regard to the quantitative material, the data analysis model adopted in this thesis study valued the investigation of the scale dimensionality by means of the facet methodology (Guttman, 1968), based on the non-metric SSA (Similarity Structure Analysis, see Guttman, 1968; Roazzi, 1995) type Multidimensional Analysis. In turn, the qualitative material was submitted to content analysis (Study 1, Bardin, 1970) and to the pattern phenomenological methodology (Study 2, Cott & Rock, 2008). The main findings of the present study indicate the self-attractiveness patterns and their phenomenology to be represented cognitively in the awareness by means of the inner speech and inner visualization elements, associated with both feelings and sensory awareness. There was no occurrence of non-symbolized thought in the carried out phenomenal analysis, though. The structure of such a pattern is set considering two dimensions, physical and non-physical, represented by the following factors: sensuality, morality, personal presentation, affection, intelligence, good humor and neatness. Such factors, when correlated and with the use of other measures, suggest the presence of statistically significant correlations, especially regarding the variables: Sexual orientation, in general, heterosexuals are closer to a positive affection ground, while homosexuals, around negative affection; Age, the youngest also being in a negative affection ground, passing to a middle ground where young adults are present, ending with between 36 and 76 year-old participants, nailed to a positive affection ground; Religiosity, also characterized by a polar layout around this variable, those who claim to be religious, the heterosexual, the adults and the elderly, as opposed to those distant from religiosity, located in an antagonistic plan, who report not to profess any faith, 14 to 20 year-old adolescents and young homosexuals; and Nationality, with the Portuguese closer to an attractiveness pattern based on moral principles, whilst the Brazilians sympathize with the sociodemographic variables of a religious nature, inferring that they influence the instancing of self-focusing processes, correlations whose meanings are corroborated by findings of the phenomenal study. This study represents an effort to give visibility to a little investigated topic in the psychological science, the nature of correction patterns and their impact on the self-focusing processes, dialoguing with a dual mind perspective, which includes psychological and phenomenal aspects of human subjectivity and cognition in order to contribute to a deeper understanding of the crucial cognitive aspects related to the instancing of more adapted and consequently less compromising forms of a meaningful and happy existence.
Melanson, Suzanne Marie. "Functional Interaction of BPV-1 E2 with the Papillomavirus Genome: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/410.
Повний текст джерелаRichards, Kathryn H. "Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/378.
Повний текст джерелаReitter, Julie N. "A Mutational Analysis of Structural Determinants Within the Newcastle Disease Virus Fusion Protein: a Dissertation." eScholarship@UMMS, 1994. https://escholarship.umassmed.edu/gsbs_diss/78.
Повний текст джерелаKolli, Madhavi. "Co-evolution of HIV-1 Protease and its Substrates: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/455.
Повний текст джерелаHeilman, Susan Ann. "Cooperative Oncogenesis and Polyploidization in Human Cancers: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/327.
Повний текст джерелаZhu, Xiaonan. "Identification of the Function of the Vpx Protein of Primate Lentiviruses: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/447.
Повний текст джерелаO'Bryan, Joel M. "Telomere Length Dynamics in Human T Cells: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/568.
Повний текст джерелаQuinlan, Edward J. "Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/585.
Повний текст джерелаYounan, Patrick. "Identification and Characterization of SNAPIN as a Novel Antagonist of HIV-1 Egress: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/460.
Повний текст джерелаMusich, Thomas A. "HIV-1 R5 Tropism: Determinants, Macrophages, and Dendritic Cells: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/599.
Повний текст джерелаChiu, Ya-Lin. "HIV-1 Gene Expression: Transcriptional Regulation and RNA Interference Studies: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/118.
Повний текст джерелаArchana, B. A. "Measurement of the viral phenomenon: New methodological exploration." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/5393.
Повний текст джерелаOLVET, THOMAS. "Developmental Metamorphoses: An Investigation into the Phenomenon of Epiphany." Thesis, 2009. http://hdl.handle.net/1974/5157.
Повний текст джерелаThesis (Master, Education) -- Queen's University, 2009-09-16 08:21:56.269
Hohls, Jeanette. "Theories and computation of second virial coefficients of electromagnetic phenomena." Thesis, 1997. http://hdl.handle.net/10413/6050.
Повний текст джерелаThesis (Ph.D.)-University of Natal, Pietermaritzburg, 1997.
Abbassi, Zeinab. "Characterizing and Leveraging Social Phenomena in Online Networks." Thesis, 2016. https://doi.org/10.7916/D8RX9C21.
Повний текст джерела