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Дисертації з теми "Vertebrate DNA"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 31 липня 2025

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1

Elango, Navin. "Evolutionary impacts of DNA methylation on vertebrate genomes." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26691.

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Thesis (Ph.D)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: Dr. Soojin Yi; Committee Member: Dr. Eric Vigoda; Committee Member: Dr. James Thomas; Committee Member: Dr. John McDonald; Committee Member: Dr. Kirill Lobachev; Committee Member: Dr. Michael Goodisman. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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2

Schofield, Julian Paul. "Studies on the structure of vertebrate genes." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386858.

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3

Long, Hannah Katherine. "Evolutionary usage and developmental roles of vertebrate non-methylated DNA." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:78b14c1d-1fa3-46f1-815f-a8ba55579c43.

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Vertebrate genomes exhibit global methylation of cytosine residues where they occur in a cytosine-guanine dinucleotide (CpG) context and this epigenetic mark is generally thought to be repressive to transcription. Punctuating this pervasive DNA methylation landscape are short, contiguous regions of non-methylated DNA which are found at two thirds of mammalian gene promoters. These non-methylated regions exhibit CpG content close to expected levels as they escape the depletion of CpGs observed across the methylated fraction of the genome. The unique nucleotide properties of these CpG island (CG

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4

Chua, Shijia Joy. "Establishing the role of RNF4 in the vertebrate DNA damage response." Thesis, University of Dundee, 2012. https://discovery.dundee.ac.uk/en/studentTheses/20679582-0300-40ac-8d30-e733210c76b4.

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RNF4 belongs to the family of SUMO-targeted ubiquitin E3 ligases (STUbLs). The role of STUbLs in maintaining genomic stability was first discovered in yeast. Theyeast STUbL mutants displayed genomic instability, elevated mutation rates, sensitivity to DNA damaging agents and also demonstrated synthetic lethality with other DNA repair genes. Although the role of vertebrate RNF4 in the DNA damage response was not yet established, it could rescue the Schizosaccaromyces pombe STUbL mutant phenotypes, showing that RNF4 is a functional homologue of the yeast STUbL proteins,and that it might be impli

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5

Barr, Alexis. "Characterising the function of CDK5RAP2 in the vertebrate centrosome." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/228639.

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The centrosome is the major microtubule organising centre in vertebrate cells. CDK5RAP2 is a human protein that localises to the centrosome. At the start of this thesis work, the function of CDK5RAP2 was uncharacterised. Significantly, cdk5rap2 is one of several centrosomal genes that are mutated in the developmental disorder Primary Microcephaly, where affected individuals have smaller brains than expected for the age- and sex-adjusted mean. Orthologues of CDK5RAP2 in the fruit fly (Centrosomin/Cnn) and in fission yeast (Mod20p) have been well characterised and are known to have important rol

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6

Veeman, Michael Terrence. "Zebrafish prickle : non-canonical Wnt/PCP functions in vertebrate gastrulation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/4999.

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7

Gohm, Birgit [Verfasser]. "The Role of DNA Repair in the Evolution of Vertebrate Longevity / Birgit Gohm." Konstanz : Bibliothek der Universität Konstanz, 2016. http://d-nb.info/1171131860/34.

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8

Yoshimura, Michio. "Vertebrate POLQ and POLβ cooperate in base excision repair of oxidative DNA damage". Kyoto University, 2007. http://hdl.handle.net/2433/135652.

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9

KOLINJIVADI, CHANDRA MOULI ARUM KUMAR. "DISSECTING THE ROLE OF BRCA2, RAD51 AND SMARCAL1 IN VERTEBRATE CHROMOSOMAL DNA REPLICATION." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/470900.

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DNA replication is a fundamental macromolecular event that is essential for cell division. During each cell cycle the entire genome has to be precisely duplicated to ensure genome integrity and stability. In the process of DNA replication, replication forks encounter endogenous and exogenous lesions and these lesions have to be rectified to transfer stable genetic material to daughter cells. Emerging evidences connected a role for Homologous Recombination (HR) proteins to replication fork protection during unperturbed DNA replication. Since HR protein, BRCA2 and Rad51 are essential for cell su

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10

Parker, Hugo. "The role of highly conserved non-coding DNA sequences in vertebrate development and evolution." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1267.

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Comparisons between vertebrate genome sequences, from mammals to fishes, have revealed thousands of conserved non-coding elements (CNEs) that are associated with developmental genes. Interestingly, the vast majority of these CNEs cannot be found in invertebrate genomes by sequence homology. As many CNEs have been demonstrated to act as enhancers in-vivo, it has been postulated that CNEs represent gene regulatory elements with crucial roles in aspects of development that are shared between vertebrates. To trace the evolution of CNE sequences in vertebrates, a preliminary search for CNEs in the

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11

Bednar, Theresa [Verfasser], George [Akademischer Betreuer] Iliakis, and Jürgen [Akademischer Betreuer] Thomale. "Efficient support of DNA replication functions by DNA ligase 3 in vertebrate cells / Theresa Bednar. Gutachter: Jürgen Thomale. Betreuer: George Iliakis." Duisburg, 2013. http://d-nb.info/1042373493/34.

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12

ROSSI, FRANCESCO. "ROLES OF THE SMC5/6 COMPLEX IN DNA REPAIR AND CHROMOSOME INTEGRITY IN VERTEBRATE CELLS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/559145.

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DNA damage response (DDR) mechanisms are crucial in all organisms to detect DNA damage and integrate its repair with cell cycle control, chromatin structure, and other adaptive changes in cell physiology. The highly conserved structural maintenance of chromosomes (SMC) complex, SMC5/6, contains both SUMO and ubiquitin ligase activities in its composition and is crucial for processing recombination structures arising during replication. Differently from related SMC complexes such as Cohesin and Condensin, the function of SMC5/6 in genome maintenance and its mode of action remain to date hardly

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13

Roach, Jared C. "Random subcloning, pairwise end sequencing, and the molecular evolution of the vertebrate trypsinogens /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8331.

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14

Bianchi, Julie. "Investigating the role of a novel primase-polymerase, PrimPol, in DNA damage tolerance in vertebrate cells." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/45544/.

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Genome duplication is an essential task our cells have to achieve prior to cell division, and requires a highly specialized replication machinery to ensure it is performed in an accurate and complete manner. DNA primase and polymerases are essential components of the replisome. Primases initiate DNA replication by synthesising short RNA primers that are then elongated by faithful and processive replicative DNA polymerases. However, both exogenous and endogenous agents can damage DNA and hinder progression of the replicative machinery. Translesion synthesis DNA polymerases assist in bypassing t

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15

Nakamura, Kyoko. "Genetic dissection of vertebrate 53BP1 : a major role in non-homologous end joining of DNA double strand breaks." Kyoto University, 2008. http://hdl.handle.net/2433/135861.

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16

Kohzaki, Masaoki. "Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse." Kyoto University, 2007. http://hdl.handle.net/2433/135695.

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17

Sangrithi, Mahesh Nataraj. "Insights into the functions of a novel vertebrate RecQ helicase in chromosomal DNA replication and in the response to stalled replication forks." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616261.

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18

Whiteman, Erin Tuxford. "The development of a real-time PCR multiplex TaqMan™ assay for vertebrate class in non-human DNA samples for forensic science." Thesis, Whiteman, Erin Tuxford (2021) The development of a real-time PCR multiplex TaqMan™ assay for vertebrate class in non-human DNA samples for forensic science. Masters by Research thesis, Murdoch University, 2021. https://researchrepository.murdoch.edu.au/id/eprint/64836/.

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Non-human DNA (e.g. animal DNA) has become an increasingly useful tool to forensic science, aiding in linking suspects, victims, and crime scenes (24). However, due to many complexities (eg. the potential for non-human DNA to be from any species and the challenges of distinguishing DNA mixtures) and limited resources, this kind of DNA often remains unanalysed in investigations. Presumptive identification of blood is not always human specific and current DNA testing usually stops when DNA samples fail human DNA testing protocols. An efficient way to routinely detect and confirm the presence of

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19

Su, Xinyi. "A vertebrate N-end rule conditional protein degradation system and its use in temporal dissection of DNA transactions in a single cell cycle." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612541.

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20

Khare, Dheeraj. "Crystallographic and functional study on DNA binding proteins: repressor and partitioning protein KorB from RP4 plasmid and the transposase "Sleeping Beauty" of vertebrate origin." [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2004/155/index.html.

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21

Katragadda, Chakravarthy. "Survey of Ehrlichia and Anaplasma species in white tailed deer and in ticks by real-time RT-PCR/PCR and DNA sequencing analysis." Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/9158.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Roman Reddy R. Ganta<br>Ehrlichia and Anaplasma species are rickettsial organisms which infect a variety of mammalian species. The organisms are transmitted from ticks and are maintained in reservoir hosts. Several pathogens have been identified in recent years as the causative agents for emerging infections in people. One of the primary reservoir hosts for the pathogens is the white tailed deer. In this study, 147 deer blood samples and 37 ticks were evaluated for the prevalence of Ehrlichia/Anaplasma species by TaqMan-bas

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22

Ryan, James L. "Multiscale landscape genetics analysis of feral pigs in the Herbert region of far-north Queensland." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/227325/1/James_Ryan_Thesis.pdf.

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Management of invasive species is notoriously difficult and often expensive. The aim of this study was to inform feral pig management practises in far-north Queensland by utilising molecular markers and geographic information systems to evaluate the affect of landscape features on feral pig population structure. This thesis evaluated landscape features at multiple spatial scales to identify landscape features that are a barrier or facilitator of feral pig movement and makes recommendations for future management strategies.

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23

Meng, Anming. "DNA fingerprinting and minisatellite variation of swans." Thesis, University of Nottingham, 1990. http://eprints.nottingham.ac.uk/13889/.

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Genetic variation in natural populations of four species of swans (Cygnus bewickii, Cygnus olor, Cygnus buccinator and Cygnus cygnus) has been investigated by examining minisatellite loci using human DNA fingerprinting probes pSPT19.6 and pSPT18.15. It has been found that swan minisatellites are highly variable. However, the degree of variation depends on the population structure and species. Bewick's Swans at Slimbridge have the highest degree of minisatellite variation, Whooper Swans at Caerlaverock come second, and then Mute Swans, and Trumpeter Swans in Montana. Comparative study of DNA fi

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24

Lau, Tze Chin. "In vitro and in vivo analyses of the impact of Mab21l2 and its targets on neural patterning and differentiation in vertebrates /." View abstract or full-text, 2010. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202010%20LAU.

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25

Petruti-Mot, Anca. "Genetic and functional analysis of topoisomerase II in vertebrates." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/8985.

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The degree of DNA supercoiling in the cell is carefully controlled by DNA topoisomerases. These enzymes catalyze the passage of individual DNA strands (Type I DNA topoisomerases), or double helices (Type II DNA topoisomerases) through one another. The purpose of the present study is to conduct a detailed analysis of the topo llα and β mRNAs expressed in several vertebrate cell lines. The final aim of this project is to analyze the relative roles of topo llα in chromatin condensation and chromosome segregation during mitosis, by performing topo llα gene targeting experiments in the DT 40 chicke

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26

Yant, Stephen Russell. "Sleeping beauty : a DNA transposon system for therapeutic gene transfer in vertebrates /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5068.

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27

MARSICH, ELEONORA. "CARATTERIZZAZIONE DI PROTEINE NUCLEARI INTERAGENTI CON IL DNA RIPETITIVO TELOMERICO DEI VERTEBRATI." Doctoral thesis, Università degli studi di Trieste, 2000. http://thesis2.sba.units.it/store/handle/item/12644.

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28

Haynes, Susan. "The history of wild and domesticated vertebrates deduced from modern and ancient DNA sequences." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325669.

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29

Cordonnier, Agnès. "Etude des mecanismes moleculaires de la replication de l'adn mitochondrial de xenopus laevis." Paris 6, 1987. http://www.theses.fr/1987PA066156.

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30

Milinkovitch, Michel. "Phylogenetic analyses of molecular data in vertebrates with special emphasis on the implications of mitochondrial DNA sequences for reevaluating morphological and behavioral evolution in cetaceans." Doctoral thesis, Universite Libre de Bruxelles, 1994. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212689.

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31

Orfanoudakis, Georges. "Diadenosine tetraphosphate : implication dans l'activite mitotique, la replication et la reparation du dna." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13121.

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Le diadenosine tetraphosphate (ap**(4)a) est le principal produit de la reaction d'aminoacylation catalysee par certaines aminoacyl-trna synthetases. L'ap**(4)a est une molecule "signal" s'accumulant a l'interphase g1/5 du cycle cellulaire des cellules eucarydes declenchant ainsi la synthese du dna precedant la division cellulaire. Quantification du contenu cellulaire en ap**(4)a et en atp apres synchronisation des cellules (hepertome de rat, fibroblaste de souris) en culture par l'aphidicoline agent bloquant les cellules en phase s et par privation de serum qui arrete la croissance en mi-phas

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32

Tratner, Isabelle. "Etude de la methylation des genes codant pour l'albumine et l'alphafoetoproteine dans differents tissus au cours du developpement et dans des cellules d'hepatomes chez le rat : correlation avec l'expression genique." Paris 6, 1987. http://www.theses.fr/1987PA066651.

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33

Bonne-Andrea, Catherine. "Contribution à l'étude des propriétés et du rôle biologique de la protéine non-histone HMG1." Paris 6, 1986. http://www.theses.fr/1986PA066451.

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34

Dunon-Bluteau, Dominique. "Etude de la region origine de replication de l'adn mitochondrial de xenopus laevis." Paris 7, 1987. http://www.theses.fr/1987PA077049.

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Chez les vertebres, l'adn mitochondrial est dna bicatenaire (15 kb). Un intermediaire de replication possedant dune boucle de deplacement (boucle d) contient un brin h neosynthetise de taille fixe et est trouve en proportion variable dans les mitochondries. Le quart du genome mitochondrial de xenopus laevis a ete sequence: la region boucle d, 4 genes d'arn de transfert, le gene de l'apocytochrome b et celui de l'arn 125. La sequence nucleotique indique que l'organisation genetique de cette region est identique a celles des mammiferes. La cartographie au nucleotide pres du brin h de la boucle d

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35

Wion, Didier. "Etude de la regulation du nerve growth factor (ngf) : clonage du gene ngf de poulet et d'un cdna codant pour la chaine lourde des neurofilaments." Paris 7, 1988. http://www.theses.fr/1988PA077168.

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La regulation de l'expression du gene ngf a ete etudiee dans la lignee de fibroblastes nurins l-929 a l'aide d'une sonde de cdna permettant de quantifier le rna messager ngf. L'abondance du ngf transcript est dependante des conditions de culture: serum, hormones thyroidiennes et acide retinoique stimulent le taux de transcription du gene ngf alors que la dexamethasone la diminue. Le gene ngf du poulet et le dna complementaire de la chaine lourde des neurofilaments ont ete clones et sequences. Les sondes moleculaires rendent possibles l'etude de la coexpression au cours de l'embryogenese des ge

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36

Blanchetot, Alain. "Organisation, structure et comparaison du gène de la myoglobine (mb) chez les mammifères." Paris 6, 1986. http://www.theses.fr/1986PA066602.

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37

GILSON, GEORGES. "Le diadenosine tetraphosphate : etudes immunochimiques et analyse de son role dans les mecanismes de reponse au stress et de reparation du dna." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13110.

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38

Sari, Marie-Agnès. "Syntheses de porphyrines cationiques solubles dans l'eau et etude de leurs interactions avec l'adn de thymus de veau." Paris 6, 1988. http://www.theses.fr/1988PA066528.

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Preparation et caracterisation de porphyrines cationiques dont le nombre et la position des charges varient. Cytotoxicite vis-a-vis des cellules l1210 et de bacteries sensibles aux intercalants et deficients ou non dans leurs systemes de reparation de l'adn

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39

Smedley, Marie A. "Nutritional and environmental effects on triploid Atlantic salmon skeletal deformity, growth and smoltification." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/23342.

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The Atlantic salmon (Salmo salar) is an iconic species that dominates the global finfish production sector with increasing market demand. The Scottish industry and government alone aspires for expansion of the sector to 210,000 t by 2020 with 154, 000 t produced in 2013. As such, there are pressures to improve sustainable development in particular to minimise the genetic impact of escapees on wild populations and reduce sea lice infection which are required for the granting of “green licenses” in Norway. The use of triploidy has been tested in the 1980’s with little success owing to suboptimal

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40

Moris, Gilbert. "Le diadenosine tetraphosphate : roles dans la regulation de la croissance et du cycle cellulaires et dans la reponse cellulaire a un stress a l'ethanol." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13118.

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41

Farache, Gabriel. "Etudes des regions genomiques delimitant les domaines des genes globine chez le poulet." Paris 7, 1987. http://www.theses.fr/1987PA077009.

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Анотація:

Cette etude concerne les regions d'adn delimitant le domaine des genes alpha globine du poulet. Dans les cellules de lignee erythroide, ce domaine est limite de part et d'autre par des regions en interaction permanente avec la matrice nucleaire. Les regions internes au domaine sont associees a la matrice pendant la transcription des genes. Les segments delimitant ce domaine se localisent a l'interieur ou a proximite de regions riches en aet t, comprenant aussi des sequences repetees. Une sequence riche en at contenant 4 sites homologues au consensus definis pour la topoisomerase ii, et un elem

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42

Kaushik, Azad Kumar. "Etude idiotypique, structurale et analyse du repertoire des autoanticorps dans deux modeles d'autoimmunite naturelle chez la souris : autoanticorps reagissant avec les globules rouges de souris bromelises, autoanticorps reagissant avec l'adn et les." Paris 7, 1987. http://www.theses.fr/1987PA077074.

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43

HEILIG, ROLAND. "Identification du gene de la myopathie de duchenne : caracterisation du messager chez le poulet : etude de la dystrophine." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR13011.

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Анотація:

La myopathie de duchenne (dmd), maladie hereditaire grave liee au chromosome y. Isolement d'un point d'acces au locus dmd, par une marche genomique, les auteurs ont isole une region de 230 kb de ce gene gigantesque. Une etude structurale comparative entre deux especes eloignees (homme et poulet) a permis d'identifier une region de la proteine soumise a tres forte pression selective. Chez la souris, le mutant "max" pourrait correspondre a l'homologue de la mutation dmd et constituer a ce titre un modele animal de choix pour l'etude de certains aspects de la pathologie humaine

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44

Walter, Philippe. "Le recepteur de l'oestradiol humain : isolement, sequence et expression de l'adnc et homologie avec l'oncogene erb-a." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13003.

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45

Sobczak, Joëlle. "Etude de l'expression genetique dans le foie de rat en hypertrophie compensatrice." Paris 6, 1988. http://www.theses.fr/1988PA066543.

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46

Labidi, Brahim. "Etude de la transcription dans des noyaux contenant un seul chromosome." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37606769q.

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47

Ronquist, Göran. "Some Characteristics of Human Prostasomes and Their Relationship to Prostate Cancer." Doctoral thesis, Uppsala universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100799.

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Background: The secretory epithelial cells of the prostate gland use sophisticated vehicles named prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. Aim: The aim of this thesis was to examine different characteristics of prostasomes, especially those derived from malignant prostate cells, linked to their potential role in diagnosis and prognostication of prostate cancer. Results: Serum samples of prostate cancer patients contained autoantibodi

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48

Giraudat, Jérôme. "Etude de l'organisation fonctionnelle des chaines polypeptidiques du récepteur nicotinique de l'acétylcholine." Paris 6, 1986. http://www.theses.fr/1986PA066403.

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49

Legrand, Alain. "Liposomes cibles et vecteurs retroviraux pour le transfert et l'expression du gene de la preproinsuline i de rat dans des cellules eucaryotes." Orléans, 1987. http://www.theses.fr/1987ORLE2011.

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Encapsulation d'adn dans des liposomes contenant du lactosylceramide dont le sucre terminal est reconnu specifiquement par des recepteurs presents sur la membrane plasmique des cellules visees, c. A. D. , les hepatocytes et les cellules endotheliales du foie et egalement les lymphocytes de la rate. Injection par voie intraveineuse des liposomes. Role de l'endocytose, dans leur internalisation. Modele genetique constitue du gene de la preproinsuline i de rat insere dans des vecteurs retroviraux permettant l'expression du gene dans des celules non insulogenes

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50

Delmas, Véronique. "Structure et proprietes biologiques du papovavirus de hamster." Paris 6, 1986. http://www.theses.fr/1986PA066550.

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Le papovavirus de hamster (hapv) possede un tropisme restreint in vivo vis a vis des keratinocytes et des lymphocytes. Il se replique dans les tumeurs cutanes qui apparaissent chez des hamsters syriens, et induit egalement des lymphomes chez le hamster. L'organisation genetique du hapv deduite de sa sequence a montre qu'il appartient a la famille des polyomavirus. Le hapv est present dans les lymphomes sous forme de multiples copies libres possedant toujours une deletion localisee dans la meme region du genome. Les signaux de transcription precoce du hapv semblent etre actives par la region pr

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