Дисертації з теми "VBMC"
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Babic, Darko Andre [Verfasser]. "Induktion und Detektion des VBNC-Zustandes in Pseudomonas aeruginosa / Darko Andre Babic." Wuppertal : Universitätsbibliothek Wuppertal, 2017. http://d-nb.info/1135940487/34.
Повний текст джерелаZANDRI, GIADA. "Ruolo di forme VBNC di stafilococco presenti in biofilm associati a cateteri endovascolari." Doctoral thesis, Università Politecnica delle Marche, 2009. http://hdl.handle.net/11566/242379.
Повний текст джерелаKoblentz, Jenna A. "Variables in VBAC Success: A Retrospective Review of Trial of Labor After Cesarean (TOLAC) and Labor Support." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/560.
Повний текст джерелаMegumi, Yuzuru. "Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex." Kyoto University, 2006. http://hdl.handle.net/2433/144318.
Повний текст джерелаCacace, A. T., Y. Ye, Faith W. Akin, Owen D. Murnane, A. Pearson, R. Gattu, and E. M. Haacke. "Voxel-Based Morphometry (VBM) in Individuals with Blast/Tbi-Related Balance Dysfunction." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/1877.
Повний текст джерелаAlleron, Laëtitia. "Etude de l'état viable non cultivable (VBNC) chez Legionella pneumophila Lens après traitements monochloramine et thermique." Poitiers, 2008. http://theses.edel.univ-poitiers.fr/theses/2008/Alleron-Laetitia/2008-Alleron-Laetitia-These.pdf.
Повний текст джерелаLegionella pneumophila , the causative agent of an atypical severe pneumonia in human called Legionnaires’ disease, is ubiquitous in aquatic environments. The treatments usually applied to eradicate this bacterium are often followed by a quick new contamination. One of the causes that could explain this colonisation could be the Viable But NonCulturable state (VBNC). The aim of this work was to study the survival of L. Pneumophila after oxidative and heat treatments and then to study the VBNC. First, we have treated Legionella suspension with monochloramine and heat. We have observed that 20 mg/L monochloramine treatment and 57. 5°C treatment lead to the VBNC state. Moreover, these bacteria could persist in this state during at least 169 days. Secondly, we have realised a partial study of Legionella proteins expressed in the VBNC state. Several proteinsexpressions, implicated in energy production, protein synthesis and virulence, were induced more than 2-fold in comparison with bacteria stressed by monochloramine or in starvation. Finally, we have search for a Resuscitation-promoting-factor Rpf in L. Pneumophila genome. An rpf-like gene, showing 33% of identity and 51% similarity with Salmonella rpf was found. This gene has been cloned but the recombinant protein obtained didn’t lead to a recovery of legionella culturability
Alleron, Laëtitia Frère Jacques. "Etude de l'état viable non cultivable (VBNC) chez Legionella pneumophila Lens après traitements monochloramine et thermique." Poitiers : I-Médias, 2008. http://theses.edel.univ-poitiers.fr/index.php?id-253.
Повний текст джерелаVeverka, Vojtěch. "Modely tranzistorů technologie CMOS 0.35 um I3T pro PSpice." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220362.
Повний текст джерелаHighmore, Callum. "Decontamination of biofilm and VBNC zoonotic pathogens on the salad leaf phylloplane for enhanced food security and safety." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/419013/.
Повний текст джерелаToni, Jufner Celestino Vaz [UNESP]. "Transições reversíveis de células de leveduras entre estados viáveis, mas não cultiváveis (VBNC) e estados viáveis e cultiváveis." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/136009.
Повний текст джерелаDiversos estados fisiológicos têm sido descritos para células de levedura durante o cultivo, como células lesionadas, células mortas e células viáveis, mas não cultiváveis (VBNC). No entanto, pouca atenção ainda é dada à formação de células viáveis, mas não cultiváveis em leveduras e seus impactos sobre o processo de fermentação. O estado VBNC, também conhecido como estado de dormência celular pode ser definido como um estado fisiológico em que os micro-organismos não são capazes de crescer em meios bacteriológicos, mas apresentam características de células vivas. Fatores químicos e ambientais têm sido relatados para induzir um estado VBNC, incluindo a falta de nutrientes, temperaturas extremas, concentrações osmóticas e oxigênio. As células de levedura no estado VBNC podem exercer influencias sobre o rendimento de biocombustível gerado no final do processo. As leveduras industriais utilizadas neste estudo foram coletadas em uma usina sucroalcooleira localizada na cidade de Américo Brasiliense-SP-Brasil. Para fornecer evidências da existência de um estado VBNC em leveduras investigou-se a capacidade das células ao entrarem no estado VBNC, aplicando estresse térmico (40°C) e osmótico (30% de sacarose). Populações viáveis foram monitoradas utilizando o corante azul de metileno, e as populações cultiváveis foram identificadas por semeadura em meio de cultura. Todos os procedimentos foram realizados em triplicata, para todas as amostras e os dados amostrais foram submetidos à análise de variância (ANOVA). Após 48 horas no período de tempo em estresse, a comparação entre as células viáveis e as células cultiváveis demonstrou a presença de células viáveis, mas não cultiváveis. Além disso, a remoção do estresse permitiu que as células fossem novamente capazes de crescer, fornecendo evidências da existência de um estado VBNC em leveduras.
Several physiological conditions have been described for yeast cells during cultivation, such as injured cells, dead cells and viable cells, but not culturable (VBNC). However, little attention is still given to the formation of viable cells, but not cultivable in yeast and its impact on the fermentation process. The VBNC state, also known as state of numbness cell can be defined as a physiological condition in which the microorganisms are not able to grow on bacteriological media, but that present characteristics of living cells. Chemical and environmental factors have been reported to induce VBNC state, including a lack of nutrients, temperature extremes, osmotic concentration and oxygen. The yeast cells in the VBNC state may influence the yield of biofuel generated at the end of the process. The yeasts used in this study were collected in a sugarcane mill located in Américo Brasiliense-SP-Brazil. To provide evidence of the existence of a state in yeast VBNC investigated the ability of cells to enter the VBNC state, applying heat stress (40°C) and osmotic (30% sucrose). Viable populations were monitored using the methylene blue dye, and cultivated populations were identified by inoculation in culture. All procedures were performed in triplicate for all samples and sample data were submitted to analysis of variance (ANOVA). After 48 hours the time of stress, the comparison between viable cells and culturable cells showed the presence of viable cells, but not culturable. Moreover, removal of stress the cells were allowed to grow again able, providing evidence for the existence of a VBNC state in yeast.
Toni, Jufner Celestino Vaz. "Transições reversíveis de células de leveduras entre estados viáveis, mas não cultiváveis (VBNC) e estados viáveis e cultiváveis /." Araraquara, 2015. http://hdl.handle.net/11449/136009.
Повний текст джерелаBanca: Maria Lucia Gonsales da Costa Araujo
Banca: Juliana Audi Giannoni
Resumo: Diversos estados fisiológicos têm sido descritos para células de levedura durante o cultivo, como células lesionadas, células mortas e células viáveis, mas não cultiváveis (VBNC). No entanto, pouca atenção ainda é dada à formação de células viáveis, mas não cultiváveis em leveduras e seus impactos sobre o processo de fermentação. O estado VBNC, também conhecido como estado de "dormência celular" pode ser definido como um estado fisiológico em que os micro-organismos não são capazes de crescer em meios bacteriológicos, mas apresentam características de células vivas. Fatores químicos e ambientais têm sido relatados para induzir um estado VBNC, incluindo a falta de nutrientes, temperaturas extremas, concentrações osmóticas e oxigênio. As células de levedura no estado VBNC podem exercer influencias sobre o rendimento de biocombustível gerado no final do processo. As leveduras industriais utilizadas neste estudo foram coletadas em uma usina sucroalcooleira localizada na cidade de Américo Brasiliense-SP-Brasil. Para fornecer evidências da existência de um estado VBNC em leveduras investigou-se a capacidade das células ao entrarem no estado VBNC, aplicando estresse térmico (40°C) e osmótico (30% de sacarose). Populações viáveis foram monitoradas utilizando o corante azul de metileno, e as populações cultiváveis foram identificadas por semeadura em meio de cultura. Todos os procedimentos foram realizados em triplicata, para todas as amostras e os dados amostrais foram submetidos à análise de variância (ANOVA). Após 48 horas no período de tempo em estresse, a comparação entre as células viáveis e as células cultiváveis demonstrou a presença de células viáveis, mas não cultiváveis. Além disso, a remoção do estresse permitiu que as células fossem novamente capazes de crescer, fornecendo evidências da existência de um estado VBNC em leveduras.
Abstract: Several physiological conditions have been described for yeast cells during cultivation, such as injured cells, dead cells and viable cells, but not culturable (VBNC). However, little attention is still given to the formation of viable cells, but not cultivable in yeast and its impact on the fermentation process. The VBNC state, also known as state of "numbness cell" can be defined as a physiological condition in which the microorganisms are not able to grow on bacteriological media, but that present characteristics of living cells. Chemical and environmental factors have been reported to induce VBNC state, including a lack of nutrients, temperature extremes, osmotic concentration and oxygen. The yeast cells in the VBNC state may influence the yield of biofuel generated at the end of the process. The yeasts used in this study were collected in a sugarcane mill located in Américo Brasiliense-SP-Brazil. To provide evidence of the existence of a state in yeast VBNC investigated the ability of cells to enter the VBNC state, applying heat stress (40°C) and osmotic (30% sucrose). Viable populations were monitored using the methylene blue dye, and cultivated populations were identified by inoculation in culture. All procedures were performed in triplicate for all samples and sample data were submitted to analysis of variance (ANOVA). After 48 hours the time of stress, the comparison between viable cells and culturable cells showed the presence of viable cells, but not culturable. Moreover, removal of stress the cells were allowed to grow again able, providing evidence for the existence of a VBNC state in yeast.
Mestre
Desneux, Jérémy. "Étude de la survie et de la viabilité de Listeria monocytogenes dans les effluents d’élevages porcins." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S123/document.
Повний текст джерелаListeriosis is a rare but serious illness caused by foodborne Listeria monocytogenes. Because of its important survival capacity in the soil, the presence of this bacteria in effluent from pig farms intended to be spread is a public health problem. One factor that may explain the persistence of L. monocytogenes in the environment is its ability to enter a viable but non-culturable state (VNC). Our studies were aimed, firstly to monitor the behavior of L. monocytogenes in effluent from pig farms (manure and lagoon effluent) including VNC forms, and also to study its adaptation at transfer to the lagoon effluent and soil. First, we have optimized the conditions of qPCR coupled with propidium monoazide (qPCR-LDCs) to adapt this method to count VNC forms of L. monocytogenes in the manure and lagoon effluent. Secondly, we compared by cultivation method, qPCR and qPCR-LDCs, the survival of two strains of L. monocytogenes RifR IIb and IVb serogroups manure inoculated in two and two lagoon effluent incubated at 8 ° C and 20 ° C. Despite their origin and different serotype, the two strains showed a similar survival in all conditions tested. The survival of both strains was affected by the temperature (higher persistence was observed at 8 ° C) and the origin of the effluent. This study showed that L. monocytogenes was able to enter the VNC state in manure and lagoon effluent regardless of temperature. VBNC forms which accounted for 83 99.8% of viable bacteria after 60 days of incubation, appeared in the early hours of contact with effluent. Their proportion, higher at the beginning of experience in the manure lagoon in the effluent, however, was of the same order of magnitude in the two types of matrices after 60 days. To better understand the adaptation of L. monocytogenes when transferred into the lagoon effluent and soil, we compared the transcriptome by RNA-Seq technology CIP 110868 strain, isolated from a slurry inoculated in sterile effluent lagoon and extracts of soil. Transcriptome analysis was performed at T0 (reference genome), after 20 minutes and 20 hours of incubation. Functional enrichment analysis revealed transcriptomic changes during the first 20 minutes of incubation in both matrices. An increase in the gene transcript levels involved in the transport of proteins and sugars was observed. The rate of transcribed genes controlled by the sigmaB factor is increased indicating the establishment of a response to osmotic and thermal stress. In addition, the adaptation of the CIP 110868 strain in soil extracts and lagoon effluent was accompanied by an increase in time of transcript levels of genes involved in virulence and gene under the control the prfA regulator
Darke, Carljohan, and Oscar Lundström. "The role of management control systems in the VBHC strategy formulation process : Exploring management control systems as a package." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297397.
Повний текст джерелаKortebi, Mounia. "Caractérisation d’une phase de persistance intracellulaire du pathogène Listeria monocytogenes." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS477/document.
Повний текст джерелаListeria monocytogenes is a facultative intracellular pathogenic bacterium responsible for a serious disease, listeriosis. Although much work has been done to characterize the virulence mechanisms of this bacterium, there is little data on the mechanisms leading to the asymptomatic carriage of L. monocytogenes in mammalian hosts. One of these mechanisms could be a phase of intracellular persistence. During prolonged infections of human epithelial cells in culture, such as hepatocytes and trophoblast cells, L. monocytogenes changes its intracellular lifestyle. After the active phase of cell-to-cell spread, the bacteria stop polymerizing actin and become trapped in single-membrane vacuoles labeled with the endosomal protein LAMP1.The aim of my thesis was to characterize these "Listeria-Containing Vacuoles" (LisCVs). We have shown that LisCVs are acidic, partially degradative compartments, labeled by the lysosomal protease cathepsin D. Their formation coincides with the disappearance of actin polymerization factor ActA from the bacterial surface and the capture of actin-free cytosolic bacteria by cell membranes. In these compartments, bacterial growth is slowed; a subpopulation is resistant to stress and can survive beyond three days of infection. The use of gentamicin during the infection protocol is not responsible for the formation of LisCVs. However, this antibiotic allows selection of vacuolar bacteria, by specifically inhibiting the growth of cytosolic bacteria. The formation of LisCVs is not specific to laboratory strains. However, the efficacy of the phenomenon could diverge according to the sequence types of L. monocytogenes strains. Vacuolar bacteria have the ability to exit the vacuoles and return to a motile and replicative state during the subculture of infected cells. When expression of the actA gene remains inactive, as in ΔactA mutants, vacuolar Listeria forms persist in host cells in a viable but non-culturable (VBNC) state. These VBNC forms can be transmitted during host cell divisions. All these results reveal a new phase of persistence in the intracellular infectious process of L. monocytogenes during prolonged infections of a subset of epithelial cells. This property could contribute to asymptomatic carriage of this pathogen in epithelial tissues, extend the incubation period of listeriosis, and make bacteria tolerant to antibiotic therapy
Tran, Dao. "Identifying risks associated with organic soil amendments: microbial contamination in compost and manure amendments." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27364.
Повний текст джерелаKoechlein, David Jacob. "A Study of the Coccoid Bodies of Prolinoboborus fasciculus (Aquaspirillum fasciculus)." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/35624.
Повний текст джерелаMaster of Science
Pasquaroli, Sonia. "Induction of viable but nonculturable state in Staphylococcus aureus biofilms obtained in vitro." Doctoral thesis, Università Politecnica delle Marche, 2011. http://hdl.handle.net/11566/242106.
Повний текст джерелаStaphylococcus aureus is a major human pathogen. Its toxins can cause disease of varying severity, including food poisoning and a number of infections. Several strains form biofilms, i.e. multicellular aggregates encased in an exopolysaccharide matrix (slime) produced by the bacteria themselves. Biofilm-producing staphylococci are frequently involved in infections associated with the use of medical devices (e.g. catheter-related bloodstream infections). These biofilms protect bacteria from both host defences and antibiotic therapy, resulting in considerable difficulty in eradication. Bacteria residing in biofilms need to cope with adverse environmental conditions, such as oxygen and nutrient deficiency, that can induce a “dormant” state, like the Viable But NonCulturable (VBNC) state. VBNC forms are a survival strategy of non-sporulating bacteria subjected to environmental stress (e.g. changes in temperature or visible light, oxygen or nutrient deficiency). The VBNC state, a potential reservoir of pathogenic microorganisms, has been described for several gram-positive and negative species, both environmental and clinical. This survival strategy is characterized by the absence of culturability on culture media, low metabolic activity, and morpho-functional changes. Moreover, optimal growth conditions can “resuscitate” true VBNC cells, restoring replication capacity and full metabolic activity. The ability of staphylococci to enter the VBNC state has never been demonstrated. This work aimed to establish (i) whether S. aureus biofilms can give rise to VBNC forms that can resuscitate in suitable environmental conditions, and (ii) the role of different stressors in inducing the VBNC state. Cultures of S. aureus 10850 (a strong slime producer) and S. aureus ATCC 25923 (a non-slime producer) were grown on filter membranes under conditions suitable for biofilm development (i.e. presence of glucose) and exposed to different stress conditions, i.e. depletion of nutrients, in the presence or absence of minimum inhibitory concentrations (MICs) and of 4-fold, 8-fold and 16-fold MICs of vancomycin, synercid and daptomycin, three antibiotics used to treat severe Gram-positive infections. Culturability was monitored at intervals of three days. After cells had reached the nonculturable state they were subjected to live-dead staining using SYBR Green I and propidium iodide and their viability was tested by epifluorescence microscopy and flow cytometry. Gene expression was analyzed using RT-PCR and Real-time RT-PCR assays targeting bacterial 16SrDNA, glsF (a housekeeping, species-specific gene) and nuc (the gene coding for a thermostable nuclease) genes. VBNC forms were then assessed for their ability to recover replication activity through exposure to favourable growth conditions. The results of these experiments showed that (i) S. aureus is capable of entering the VBNC state provided that cells are contained in biofilm, because viable but nonculturable cells of S. aureus ATCC 25923 (the non-slime producer) were never recovered; (ii) VBNC S. aureus forms can be induced by starvation and antibiotics; (iii) VBNC S. aureus cells retain their metabolic activity, as demonstrated by positive gene expression assays; and (iv) VBNC S. aureus cells exposed to suitable culture conditions can revert to the culturable state (resuscitation). VBNC staphylococci may have a significant clinical role, since they can pass from the dormant state, where they are undetectable by routine methods within biofilm, to full metabolic and replication activity, causing severe infections.
Linke, Stefan [Verfasser]. "Untersuchungen zur erhöhten Toleranz von biofilmassoziierten Mikroorganismen und die Ausbildung von vbnc-Zuständen bei Pseudomonas aeruginosa gegenüber chlorabspaltenden Verbindungen / Stefan Linke." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1044870257/34.
Повний текст джерелаNicklas, Anne [Verfasser]. "In-vivo-Untersuchungen zu strukturellen Gehirnveränderungen bei chronischem lumbalem Rückenschmerz mittels Voxel-basierter Morphometrie (VBM) / Anne Nicklas." Köln : Deutsche Zentralbibliothek für Medizin, 2013. http://d-nb.info/1044190647/34.
Повний текст джерелаSchmalzigaug, Vivian. "Uma experiência na utilizacao do vbm (value based management) como ferramenta de desenvolvimento de estratégias de negócio." reponame:Repositório Institucional do FGV, 1996. http://hdl.handle.net/10438/5508.
Повний текст джерелаEsta tese baseia-se na experiência adquirida com a participação num projeto de implantação do conceito de Value Based Management em urna empresa multinacional de bens de consumo. A maior parte do material aqui comentado foi colhido durante o primeiro semestre do ano de 1995 - período em que durou o projeto - e parte durante duas semanas no início do ano, nas quais participei em Londres de um treinamento intensivo, ministrado por uma conceituada firma de consultoria internacional, sobre a teoria e prática deste novo conceito, juntamente com diversos participantes de outros projetos VBM ao redor do mundo como Estados Unidos, França, Itália, Alemanha, Inglaterra, Espanha, entre outros
Serafin, Marta <1995>. "The family firms succession paradox: how to preserve family influence while hiring external managers. A VBM perspective." Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/16987.
Повний текст джерелаMseddi, Eya. "Exploration cérébrale structurelle et morphologique de la posture chez des patients atteints de sclérose latérale amyotrophique." Thesis, Paris 10, 2017. http://www.theses.fr/2017PA100162.
Повний текст джерелаThe Amyotrophic Lateral Sclerosis [ALS] is an idiopathic pathology with a fatal outcome. It is characterized by a progressive and selective degeneration of motor neurons in the central and peripheral nervous system. ALS is no longer exclusively identified as a disease of the pyramidal pathway, but it is considered more broadly as multisystem neurodegenerative pathology. However, the analysis of postural processes in these patients has not been well studied in the literature. Multimodal brain imaging (Diffusion Tensor Imaging [DTI] and Voxel Based Morphometry [VBM]) exploration was performed for ALS patients with postural instability [AIP] and without postural instability [SIP] to test the morphometric and structural integrity of postural cortical and subcortical regions. A significant increase of gray matter in caudate nucleus volume has been noticed for stable patients (SIP vs controls p<0.001, SIP vs AIP p<0.01). The structural evaluation revealed a decrease of the Fractional Anisotropy [FA] at the Supplementary Motor Area [SMA] level in both groups of patients compared to controls (controls vs SIP p<0.05, controls vs. AIP p<0.001). At the caudate nucleus, the AIP group showed FA value decrease compared to controls (p<0.001) and SIP subjects (p<0.05). Thus, these results would contribute to a better characterization and understanding of the cortical and subcortical impairments of the postural regions in ALS patients
Shoemaker, Esther Susanna. "Childbirth Decision Making Processes: Influences on Mode of Birth After a Previous Caesarean Section." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35504.
Повний текст джерелаSantiwatanakul, Somchai. "A study of the coccoid form and the autolysins of Campylobacter upsaliensis." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30509.
Повний текст джерелаPh. D.
BOWNE, SHELL L. "MIDWIVES IN A PRECARIOUS BALANCE OF POWER WITHIN THE HEALTH CARE SYSTEM OF THE UNITED STATES." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1016569336.
Повний текст джерелаStreitbürger, Daniel-Paolo. "Investigating Brain Structure Using Voxel-Based Methods with Magnetic Resonance Imaging." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-132638.
Повний текст джерелаVigneau-Roy, Nicolas. "Structure et fonction du cerveau : lien entre la densité vasculaire régionale et l'amplitude du signal BOLD." Mémoire, Université de Sherbrooke, 2013. http://hdl.handle.net/11143/6370.
Повний текст джерелаKoch, Amelie [Verfasser], and Göran [Akademischer Betreuer] Hajak. "Morphologische Veränderungen bei Patienten mit chronischem Tinnitus - Eine Studie mit voxelbasierter Morphometrie (VBM) / Amelie Koch. Betreuer: Göran Hajak." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1023312298/34.
Повний текст джерелаSchröder, Chantal [Verfasser], and Andreas [Akademischer Betreuer] Jansen. "VBM-Studie zum Einfluss endogener sowie exogener weiblicher Sexualhormone auf die zerebrale Morphometrie / Chantal Schröder ; Betreuer: Andreas Jansen." Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1211086399/34.
Повний текст джерелаEpalle, Thibaut. "Suivi de l'état viable non cultivable de souches de Legionella pneumophila soumises à différents stress (thermique ou chloré) : Evaluation de leur pouvoir pathogène." Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET001T/document.
Повний текст джерелаLegionella pneumophila, the causative agent of legionellosis is transmitted to human through aerosols from environmental sources and invades lung’s macrophages. It also can replicate within various protozoan species in environmental reservoirs. Following exposures to various stresses, L. pneumophila enters a Viable Non Cultivable state (VBNC) which is likely to be a survival strategy. The objective of our work was to study the VBNC forms of several strains of L. pneumophila serogroup 1 obtained after thermal and chemical treatments and to evaluate the infectivity of these VBNC forms against macrophages and alveolar epithelial cells. First we studied the physiological patterns of the three different strains (Philadelphia GFP 008, 044 clinical and environmental RNN). For all strains we observed the presence of VBNC bacteria in the native (non stressed) state. The results show that for each strain, three populations of Legionella can be identified: viable and culturable, VBNC and dead cells. Once submitted to the various stresses, we observed that each strain had its own physiological pattern and the presence (or not) of VBNC bacteria was dependent on the applied treatment and the strain used. The second part was related to the study of the pathogenicity of these VBNC forms against macrophages or epithelial cells. The study focused on heat shock treatment at 70°C for 30 min and chlorine dioxide treatment at 4, 6 and 7 mg/L for 60 min at room temperature. The results show that no Legionella VBNC forms were able to grow within the cells and no growth on BCYE medium was observed after co-culture. Then we investigated the behavior of L. pneumophila resuscitated after culture on ameba within macrophages. The results shows that Legionella VBNC induced by heat shock treatment and resuscitated by Acanthamoeba polyphaga co-culture are able to infect macrophages. In conclusion, these results suggest that: (i) the VBNC forms of L. pneumophila are not infectious for macrophages and alveolar epithelial cells in vitro and; (ii) they can be pathogenic for human cells after revivification by an amoeba (A. polyphaga)
Rao, Aishwarya Pradeep, and Aishwarya Pradeep Rao. "Plant Antimicrobials: Inactivation of Foodborne Pathogens or Induction into the VBNC State and Their Effects on the Sensory Properties of Organic Romaine Lettuce." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626401.
Повний текст джерелаDI, TORO MARIA ROSARIA. "Biodiversity of Dekkera/Brettanomyces in Apulian wines: isolation, characterization of representative biotypes and assessment of control strategies based on biotechnological resources management." Doctoral thesis, Università di Foggia, 2015. http://hdl.handle.net/11369/337553.
Повний текст джерелаСиром'ятникова, Оксана Валеріївна, та Р. В. Муравльова. "Особливості оцінки ефективності діяльності промислового підприємства". Thesis, НТУ "ХПІ", 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/25951.
Повний текст джерелаЧернова, В. В., В. В. Чернова та V. Chernova. "Контролінг в управлінні вартістю підприємства". Diss., Одеський національний економічний університет, 2017. http://dspace.oneu.edu.ua/jspui/handle/123456789/6687.
Повний текст джерелаВ диссертационной работе рассмотрены теоретические основы и практические рекомендации по управления стоимостью предприятий на основе внедрения инструментов контроллинга. Обоснована необходимость построения системы контроллинга в стоимостно-ориентированной модели менеджмента (VBM) для оценки влияния управленческих решений на показатели стоимости. Проанализированы существующие методы оценки стоимости предприятия, доказана целесообразность применения в VBM индикаторов EVA, CVA, CFROI, которые предложено использовать в интегрированном анализе. Проведен анализ современного состояния и перспектив рынка предприятий производителей КПП. Доказано, что основным воздействующим фактором на показатели стоимости таких предприятий является биржевая цена основного материала. Предложена агрегация систем планирования, управленческого учета и управленческой отчетности в информационно-аналитическую платформу, которая построена на принципах контроллинга и направлена на мониторинг изменений факторов стоимости предприятия с учетом влияния биржевой цены на основной материал. Даны методические рекомендации по проектированию системы планирования, управленческого учета, отчетности и оценки эффективности деятельности в VBM.
The dissertation is devoted to the study of theoretical, methodical and organizational-practical principles of value based management and adaptation of controlling tools to the needs of industrial enterprises. The study covers the value based controlling concept and its implementation in business practice. The building of controlling system in frameworks of the value-based management (VBM) is needed for the evaluation of the influence of management decisions on value indicators of business (company). The analysis of existing methods for estimating the value of the enterprise has demonstrated the feasibility of using integrated methods and indicators EVA, CVA, CFROI in the value-based management. The full picture of decision making can be got if all indicators are used in the integrated analysis, where EVA – shows the ability of the business to make a profit, CVA – sufficiency of cash flow for business activity, CFROI – the size of business profitability in percent. The focus of the research was given on cable and wires manufacturers of Ukraine. It assessed current condition, dynamics, problems, possibilities and potential opportunities for their development. The hypothesis was proved, that main factor affecting the indicators of these enterprises value is the exchange price of the main material. The work presents scientifically-methodical approach to design of value-based controlling system. It allows to determine the key factors of value and the degree of their influence on value indicators – at the diagnostics phase, and to determine the basic rules of the controlling concept – the rules of results, processes and coordination – at the planning and engineering phase. Rules of results reveal what is the criterion of performance of tasks at each stage - and the scale of their optimality. Rules of processes concerned the nature and content of activities, interpretation of information flow about internal and external business processes, coordination rules – define the interaction both between the general goals and objectives, as and within them. Controlling system design in value based management model will provide a clear link enterprise planning and current activities with cost factors; integrate and coordinate all the administrative processes of the enterprise to increase the value, to promptly respond changes in the external and internal environment, taking the deviations from the set objectives in considering with the interests of owners and investors, avoiding manipulation by management. The proposed information and analytical platform is a result of aggregation of planning, management accounting and management reporting systems. It’s based on the principles of controlling and aims to monitor changes in the factors and value indicators taking into consideration the impact of the stock-exchange prices on the main material. Methodical recommendations on systems planning engineering, management accounting, reporting and evaluation of the enterprise's working in the VBM model were given. An information model for estimating the value of an enterprise has been developed. It considers the dividends that must be accrued, and those that can actually be paid. This will allow to assess effectiveness of management in solving strategic problems and to provide the ability to plan and monitor the deviations of indicators from target values for the generation relevant management decisions.
Noack, Henrike Anne [Verfasser]. "Quantitative EEG-Analyse bei Parkinson Patienten ohne Demenz in Korrelation zu strukturellen MRT-Veränderungen : eine VBM-Studie / Henrike Anne Noack." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068590203/34.
Повний текст джерелаLima, Luiz Cesar dos Santos. "Proposta de um método de análise da viabilidade dos modais para o transporte do carro de combate VBC Leopard 1A5BR." Universidade Tecnológica Federal do Paraná, 2012. http://repositorio.utfpr.edu.br/jspui/handle/1/599.
Повний текст джерелаThe National Mobilization is a set of activities that aims to enable Brazil to plan and execute actions in the field of National Defence toensure the security and sovereignty of the country. When it is ordered by the state organs that are part of the System of National Defense must be prepared and equipped to execute its functions. The Brazilian Army, one of these agencies, in 2006, purchased 250 armored combat vehicles, of which 216 to be distributed among their cavalry units in Brazil. The aim of this study is to present the best alternative transportation logistics to carry these tanks in a military organization, from a given scenario, with lower cost and / or time. To achieve the goal consultations through interviews and correspondence with experts in transport, military transport and armored vehicles. The consultations allowed to define the main advantages and disadvantages of transportation modes and factors relevant to transport armored vehicles, permitting the formulation of the transport network and development of an instrument feasibility of transportation modes (check list) to be applied to routes of transport. A problem of transporting armored vehicles, from a hypothetical scenario, was solved by a mathematical model with the objective of minimizing cost or time. It was concluded that the mathematical model is a tool that can aid decision making in the transport of armored vehicles, but the best choice will depend on the proper analysis of the modes of transportation available and the correct formulation and application of the instrument feasibility of transportation modes.
Ducret, Adrien. "Viabilité et cultivabilité de L. Pneumophila : étude des mécanismes impliqués dans la récupération de l'aptitude à former des colonies." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX22105.
Повний текст джерелаLegionella pneumophila is the causative agent of Legionellosis transmitted by air from industrial or natural aerosols (installation of hot water, cooling towers. . . ) Currently standard procedure that uses the agar cultur media governs the detection and isolation of L. Pneumophila. However, like many Gram-negative bacteria, Legionella pneumophila is able to enter in a viable state but non culturable (VBNC) during starvation or stress conditions. In this study, we showed that the different treatment biocides traditionally used to eradicate. L. Pneumophila in industrial plants, induced the formation of VBNC cells, determined using viability markers and reference agar medium (BCYE). However, detailled analysis of the viability markers shows that they have a progressive detetioration of the viability of different descriptors used as the biocide concentration increases. Assuming initially that the loss of culturability of VBNC cells is potentially due to oxidative stress generated during spreading, we sought to optimize the reference medium. During the study many compounds (antioxidants, metabolic. . . ) have been identified as benefical to the restoration of culturability for a fraction of the population after stress but also, interestingly, during growth. The co-existence of two populations (culturable on the reference medium or the supplemented medium) with the relative proportion changes over time, raises to date, a number of questions about the origin and physiological relevance of each of the two populations. For technical reasons, these issues can be resolved only with methods focused on the individual rather than on the overall response of a population. In this sense, we initiated the development of an observation chamber and a fluidic system that now allows as realtime monitoring of cell viability observed and their evolution over time or during a stress while observing ultimately their respective ability to form a colony
Blouw, Mbuyiselo Edwin. "A study of the use of value based management (VBM) by multinational entities in the Eastern Cape motor industry cluster (ECMIC)." Thesis, Nelson Mandela Metropolitan University, 2005. http://hdl.handle.net/10948/421.
Повний текст джерелаGryga, Martin. "Strukturelle und funktionelle Hirnveränderungen nach fünf Tagen komplexen motorischen Lernens." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-109708.
Повний текст джерелаParaguassú, Aroldo Montenegro Duarte. "Vantagem competitiva na indústria de reparos automotivos : abordagem dialógica da visão baseada no mercado (VBM) e da visão baseada no mercado em recursos (VBR)." Universidade de Fortaleza, 2008. http://dspace.unifor.br/handle/tede/79454.
Повний текст джерелаIn the area of strategy, much is discussed about the potential of complementary or antagonism of MBV - Market-based View (Competitive Strategy) and RBV - Resources-based View. However, few studies have addressed the consideration of these perspectives, expanded in a dialogical approach to the principles of Complex Reasoning. This study aims to answer a question on exactly this point: How does dialogical approach influences the understanding of competitive advantage, according to MBV and RBV? In this sense, the study provides a framework in which competitive advantage is understood according to a dialogical approach of MBV and RBV. To that end, there was a case study in two phases, the strategic group of independent auto-centers in the automotive repair segment of Fortaleza / Brazil. In the first phase, were interviewed 15 experts of the sector in two meetings of focus groups, from which emerged six inductor themes related to competitive advantage. These themes guided the second phase of the interviews with entrepreneurs / managers of 13 illustrative cases. The illustrative cases were important to describe mutual inter-relations that show situations up where the themes, it prays antagonistic, that inhibit and reduce his effects, it prays if they complement in the almost passive form and even they compete being stimulated and done so that the competitive advantage is enlarged. The main contribution of this study to propose a framework that aims to facilitate the understanding of this new approach and can be understood as an array of static position in terms of a dialogical vision of competitive advantage in the MBV and RBV.
Na área de estratégia, muito se discute sobre o potencial antagonismo ou complementaridade da VBM - Visão Baseada no Mercado (Estratégia Competitiva) e da VBR - Visão Baseada em Recursos. Poucos estudos, no entanto, se endereçaram para a consideração dessas perspectivas, ampliadas da dimensão concorrente em uma abordagem dialógica segundo a Teoria da Complexidade. O presente estudo visa a responder exatamente a uma questão ligada a este ponto: como a abordagem dialógica influencia na compreensão da vantagem competitiva, segundo a VBM e a VBR? Neste sentido, se propõe a apresentar um framework, no qual a vantagem competitiva seja compreendida segundo uma abordagem dialógica da VBM e da VBR. Para tanto, foi realizado um estudo de caso, em duas fases, no grupo estratégico dos auto-centers independentes do segmento de reparos automotivos de Fortaleza/Ceará/BR. Na primeira fase, foram ouvidas as contribuições de 15 experts do setor em duas reuniões de grupos focais, de onde emergiram seis temáticas indutoras da vantagem competitiva que, na segunda fase, orientaram o roteiro de entrevistas a empresários/gestores de 13 casos ilustrativos. Os casos ilustrativos foram importantes para descrever inter-relações mútuas que evidenciam situações onde as temáticas, ora antagônicas, se inibem e reduzem seus efeitos, ora se complementam de forma quase passiva e mesmo concorrem estimulandose e fazendo com que se amplie a vantagem competitiva. Como principal contribuição deste estudo, ressalta-se a proposição de um framework que pretende facilitar a compreensão dessa nova abordagem e pode ser entendido como uma matriz de posicionamento estática, no que tange a uma visão dialógica da vantagem competitiva, segundo a VBM e a VBR.
McDougald, S. Diane School of Microbiology & Immunology UNSW. "Regulation of starvation and nonculturability in the marine pathogen, Vibrio vulnificus." Awarded by:University of New South Wales. School of Microbiology and Immunology, 2000. http://handle.unsw.edu.au/1959.4/19118.
Повний текст джерелаBloch, Zdzislaw, and Martin Larsson. "Modeller för Value Based Management : teoretisk och empirisk studie." Thesis, Södertörn University College, School of Business Studies, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1663.
Повний текст джерелаSyfte:
Vi vill med vår uppsats öka förståelsen för vad VBM-konceptet kan bidra till för ett företag och visa hur olika VBM-modeller används i praktiken.
Metod:
En teoretisk studie som huvudsakligen baseras på sekundär data där vi sammanställer olika teorier och modeller tillhörande VBM-konceptet samt tidigare forskning. Detta kompletteras med vår egen empiri som består av intervjuer som genomfördes vid två företeg.
Resultat:
Resultatet visar att det inte är något företag som använder sig av flera VBM-mått på olika nivåer. Oftast bestämmer man sig för en modell och använder den till alla nivåer, möjligtvis kompletterar man med mindre nyckeltal. Val av modell är inte det viktigaste utan att man väljer någon modell som gör så att kapitalkostnaden tydliggörs för att säkerställa att intäkterna täcker kapitalkostnaderna.
Albajara, Saenz Ariadna. "On the association between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A neuroimaging investigation." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/303539.
Повний текст джерелаDoctorat en Sciences psychologiques et de l'éducation
info:eu-repo/semantics/nonPublished
Shah, Manoj Kumar. "Characterizing the Impact of Stress Exposure on Survival of Foodborne Pathogens." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29389.
Повний текст джерелаSchreiner, Daniela [Verfasser], and Göran [Akademischer Betreuer] Hajak. "Der Einfluss des Val66Met-Polymorphismus des Brain-Derived Neurotrophic Factor (BDNF)-Gens auf die neuronale Plastizität: Eine VBM- und TMS-Studie / Daniela Schreiner. Betreuer: Göran Hajak." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1023398834/34.
Повний текст джерелаNicol, Marion. "Recherche d'outils thérapeutique innovants pour lutter contre la bactérie Acinetobacter baumannii." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMR132/document.
Повний текст джерелаToday, Acinetobacter baumannii is one of the most problematic pathogens in the world. This bacterium is responsible for worldwide epidemic outbreaks associated with dramatic mortality rates. It possesses high capacities to evade the immune host system and to resist to numerous available antibacterial agents. A. baumannii is also able to persist into hospital environment due to high adhesion abilities which induce community development. This process is also associated to an enhanced survival rate. In Acinetobacter genus, community modes of lif can take two forms : biofilm and pellicle. In this study on the strain ATCC 17978, we tried to discriminate these two lifestyles by a large scale proteomic analysis. We have confirmed the presence of many common community markers (transporters, ion acquisition secretion systems, adhesins and pili) and highlighted systems specifically related to biofilm (pilus Fim, T2SS, T1SS / pump A1S_0535-38, LPS / LOS, capsular pattern) and pellicle communities. Furthermore the proteomic analysis of an avirulent A. baumannii strain, SDF, in biofilm allowed to highlight peculiar metabolic pathways, specific adhesion determinants but very few markers shared by ATCC 17978. This demonstrated the difficulty in developing a treatment directed against A. baumannii biofilm. Then, we tested different approaches to prevent and eradicate biofilms. The first one targeted the Quorum Sensing system (QS), an essential communication system for cell coordination. We have showed that monounsaturated fatty acids (palmitoleic acid and myristoleic acid), like virstatin prevent the community formation of A. baumannii by inhibiting the expression of the abaR regulator required for QS. In a second strategy, we have evaluated the antibacterial and antibiofilm activity of a new natural compound : the squalamine. We showed for the first time that if ciprofloxacin treatment was able to induce a dormancy population (persistent/VBNCs) in A. baumannii, squalamine was able to eradicate this population of dormant cells
Perdigao, Cristhiana. "Assessment of horizontal bore drains performance in brown coal mines in the Latrobe Valley." Thesis, Federation University Australia, 2021. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/181877.
Повний текст джерелаMasters by Research
BERLINGERI, MANUELA. "Brain dynamics associated with graceful and pathological aging: new morphometric and fMRI evidence." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/7816.
Повний текст джерелаDelmaire, Christine. "Exploration in vivo grâce à l'IRM des atteintes fonctionnelles, morphologiques et microstructurelles dans la dystonie." Paris 6, 2007. http://www.theses.fr/2007PA066595.
Повний текст джерелаDystonia is a movement disorder whose pathophysiology is not fully understood. To date, conventional MR imaging was unsuccessful in showing structural abnormality in primary dystonia. New recent imaging techniques, such as voxel based morphometry (VBM) and diffusion tensor imaging (DTI), can be utilized to explore more precisely the pathophysiology of dystonia. In this work, we used several MRI methods to investigate the pathophysiology of dystonia. We used fMRI to determine whether the selectivity of neuronal representation of basal ganglia neurons was altered in the putamen of patients with focal hand dystonia before and after rehabilitation. Using voxel-based morphometry and DTI, we tested the hypothesis that structural or microstructural changes occur in the sensorimotor basal ganglia - cortical circuit in primary focal hand dystonia. Lastly, we combined structural imaging and fiber tracking to determine the functionnal territory of the basal ganglia that is damaged in post stroke dystonia. Overall, our results show that cortico striatal thalamo cerebellar sensorimotor circuit is likely to play a fundamental role in the pathophysiology of the dystonia
Ledoux, Andrée-Anne. "Neurofunctional and Neuroanatomical Hippocampal Deficits and Connectivity Differences in Schizophrenia Compared to Healthy Control Participants Tested on a Virtual Reality Navigation Wayfinding Task: An fMRI, VBM and Effective Connectivity Study." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24063.
Повний текст джерела