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Статті в журналах з теми "Urological biomaterials"

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Автор: Grafiati

Опубліковано: 6 вересня 2023

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1

Raut, Piyush W., Anand P. Khandwekar, and Neeti Sharma. "Polyurethane–polyvinylpyrrolidone iodine blends as potential urological biomaterials." Journal of Materials Science 53, no. 16 (May 22, 2018): 11176–93. http://dx.doi.org/10.1007/s10853-018-2445-7.

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2

D'Addessi, Alessandro, Matteo Vittori, and Emilio Sacco. "An Introduction to Biomaterials in Urology." Urologia Journal 80, no. 1 (January 2013): 20–28. http://dx.doi.org/10.5301/ru.2013.10767.

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Aim of this paper is to provide a brief introduction on the biomaterials used in urology, discussing issues of biocompatibility and biomaterials available for use. Information will moreover be provided on basic elements of Tissue engineering and Regenerative medicine, rapidly advancing technologies that could finally shift in the next future from the laboratory to clinical practice, with special interest to possible urological applications.

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3

Zhang, Chaoxing, Jiajia Lin, and Huinan Liu. "Magnesium-based Biodegradable Materials for Biomedical Applications." MRS Advances 3, no. 40 (2018): 2359–64. http://dx.doi.org/10.1557/adv.2018.488.

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ABSTRACTMagnesium (Mg)-based biomaterials have attracted increasing attention in biomedical applications, such as orthopaedic, cardiovascular, urological, and neural applications because of the biocompatibility, biodegradability, antibacterial properties, and excellent mechanical properties. However, rapid degradation of Mg is the major concern for many clinical applications. Alloying Mg with other elements and engineering proper surfaces are the two approaches to control the degradation of Mg-based biomaterials. Our lab has investigated several classes of Mg-based biodegradable alloys and various surface treatment methods for medical implant and device applications. This mini-review highlights key research progress on Mg-based biomaterials and suggests future directions for Mg-based biomaterials.

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4

Williams, H., A. Singla, K. Broadrick, B. Krishnamurthy, and P. Van de Vord. "UP-2.185: In Vivo Responses to Biomaterials Used in Urological Reconstruction." Urology 74, no. 4 (October 2009): S290. http://dx.doi.org/10.1016/j.urology.2009.07.404.

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5

Caneparo, Christophe, Stéphane Chabaud, and Stéphane Bolduc. "Reconstruction of Vascular and Urologic Tubular Grafts by Tissue Engineering." Processes 9, no. 3 (March 12, 2021): 513. http://dx.doi.org/10.3390/pr9030513.

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Tissue engineering is one of the most promising scientific breakthroughs of the late 20th century. Its objective is to produce in vitro tissues or organs to repair and replace damaged ones using various techniques, biomaterials, and cells. Tissue engineering emerged to substitute the use of native autologous tissues, whose quantities are sometimes insufficient to correct the most severe pathologies. Indeed, the patient’s health status, regulations, or fibrotic scars at the site of the initial biopsy limit their availability, especially to treat recurrence. This new technology relies on the use of biomaterials to create scaffolds on which the patient’s cells can be seeded. This review focuses on the reconstruction, by tissue engineering, of two types of tissue with tubular structures: vascular and urological grafts. The emphasis is on self-assembly methods which allow the production of tissue/organ substitute without the use of exogenous material, with the patient’s cells producing their own scaffold. These continuously improved techniques, which allow rapid graft integration without immune rejection in the treatment of severely burned patients, give hope that similar results will be observed in the vascular and urological fields.

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6

Davis, N. F., B. B. McGuire, A. Callanan, H. D. Flood, and T. M. McGloughlin. "Xenogenic Extracellular Matrices as Potential Biomaterials for Interposition Grafting in Urological Surgery." Journal of Urology 184, no. 6 (December 2010): 2246–53. http://dx.doi.org/10.1016/j.juro.2010.07.038.

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7

Farmanova, Nodira Takhirovna, Lola Tairkhanovna Pulatova, Dildor Irgashevna Mambetova, Arzikul Dzhurakulovich Nurullaev, and Dlafruz Kabiljanovna Khudoykulova. "CHEMICAL COMPOSITION OF THE UROLOGY COLLECTION." chemistry of plant raw material, no. 1 (March 16, 2021): 227–32. http://dx.doi.org/10.14258/jcprm.2021017542.

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In order to identify the main biologically active complex, there were carried out a chemical analysis of the urological collection. As a result of the study, there were established the presence of water-soluble polysaccharides in the urological collection 3.2±0.3%, amino acids – 406.3±0.01 nmol, ascorbic acid 45.0±0.5 mg%, carotenoids 0.50±0.04 mg%, organic acids 1.87±0.2%, essential oil – 0.79±0.1%, flavonoids – 0.43±0.04%, coumarins – 0.18±0.2%, phenolcarboxylic acids – 0.41±0.2%, tannins – 5.3±0.4%, saponins (glycyrrhizic acid) – 1.15±0.2%, as well as macro- and micronutrients – 19596.65±0.002 mg/kg. The elemental composition of the collection is represented by 17 vital elements (K, Ca, Mg, Na, P are the dominant components). During studies have also shown the presence of 14 amino acids, 7 of which are essential (44.6% of the total amino acids). It can be clearly stated that the indicator components of the collection are polyphenolic compounds (flavonoids, tannins, etc.) and saponins (glycyrrhizic acid) predominantly passing into aqueous extracts (the proposed dosage form) of the collection, the complex of which determines the specific activity of the studied urological collection. The obtained data were used to develop the authenticity and criteria of the quality of the studied collection.

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8

Tunney, M. M., and S. P. Gorman. "Evaluation of a poly(vinyl pyrollidone)-coated biomaterial for urological use." Biomaterials 23, no. 23 (December 2002): 4601–8. http://dx.doi.org/10.1016/s0142-9612(02)00206-5.

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9

Zhao, J., S. Zeiai, Å. Ekblad, A. Nordenskjöld, J. Hilborn, C. Götherström та M. Fossum. "Transdifferentiation of autologous bone marrow cells on a collagen-poly(ε-caprolactone) scaffold for tissue engineering in complete lack of native urothelium". Journal of The Royal Society Interface 11, № 96 (6 липня 2014): 20140233. http://dx.doi.org/10.1098/rsif.2014.0233.

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Urological reconstructive surgery is sometimes hampered by a lack of tissue. In some cases, autologous urothelial cells (UCs) are not available for cell expansion and ordinary tissue engineering. In these cases, we wanted to explore whether autologous mesenchymal stem cells (MSCs) from bone marrow could be used to create urological transplants. MSCs from human bone marrow were cultured in vitro with medium conditioned by normal human UCs or by indirect co-culturing in culture well inserts. Changes in gene expression, protein expression and cell morphology were studied after two weeks using western blot, RT-PCR and immune staining. Cells cultured in standard epithelial growth medium served as controls. Bone marrow MSCs changed their phenotype with respect to growth characteristics and cell morphology, as well as gene and protein expression, to a UC lineage in both culture methods, but not in controls. Urothelial differentiation was also accomplished in human bone marrow MSCs seeded on a three-dimensional poly(ε-caprolactone) (PCL)–collagen construct. Human MSCs could easily be harvested by bone marrow aspiration and expanded and differentiated into urothelium. Differentiation could take place on a three-dimensional hybrid PCL-reinforced collagen-based scaffold for creation of a tissue-engineered autologous transplant for urological reconstructive surgery.

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10

Casarin, Martina, Tiago Moderno Fortunato, Saima Jalil Imran, Martina Todesco, Deborah Sandrin, Massimo Marchesan, Gino Gerosa, et al. "Preliminary In Vitro Assessment of Decellularized Porcine Descending Aorta for Clinical Purposes." Journal of Functional Biomaterials 14, no. 3 (March 2, 2023): 141. http://dx.doi.org/10.3390/jfb14030141.

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Conduit substitutes are increasingly in demand for cardiovascular and urological applications. In cases of bladder cancer, radical cystectomy is the preferred technique: after removing the bladder, a urinary diversion has to be created using autologous bowel, but several complications are associated with intestinal resection. Thus, alternative urinary substitutes are required to avoid autologous intestinal use, preventing complications and facilitating surgical procedures. In the present paper, we are proposing the exploitation of the decellularized porcine descending aorta as a novel and original conduit substitute. After being decellularized with the use of two alternative detergents (Tergitol and Ecosurf) and sterilized, the porcine descending aorta has been investigated to assess its permeability to detergents through methylene blue dye penetration analysis and to study its composition and structure by means of histomorphometric analyses, including DNA quantification, histology, two-photon microscopy, and hydroxyproline quantification. Biomechanical tests and cytocompatibility assays with human mesenchymal stem cells have been also performed. The results obtained demonstrated that the decellularized porcine descending aorta preserves its major features to be further evaluated as a candidate material for urological applications, even though further studies have to be carried out to demonstrate its suitability for the specific application, by performing in vivo tests in the animal model.

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11

Popov, S. V., I. N. Orlov, T. M. Topuzov, M. L. Gorelik, M. A. Perfil’yev, and M. A. Kotlov. "The use of platelet-rich plasma (PRP) in urology." Urology Herald 11, no. 1 (April 8, 2023): 134–42. http://dx.doi.org/10.21886/2308-6424-2023-11-1-134-142.

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Platelet-rich plasma (PRP) is one of the most common and practicable plasma-therapy techniques. The wide therapeutic range for the use of this technique in various medical fields is due to its high content of growth factors, cytokines, and chemokines. The property of PRP to induce tissue regeneration is particularly highlighted, which is used actively for the treatment of a broad range of urological diseases. The review aimed to highlight the accumulated material on the topic of the use of autologous biomaterials based on blood in urology. This article highlights the urgent need for further study of the prospects for the use of autoplasma technologies in wide multicenter studies.

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12

Kim, Do Yeon, Xiangzhou Tan, Moonkwang Jeong, Dandan Li, Arkadiusz Miernik, and Tian Qiu. "A High-Fidelity Artificial Urological System for the Quantitative Assessment of Endoscopic Skills." Journal of Functional Biomaterials 13, no. 4 (December 16, 2022): 301. http://dx.doi.org/10.3390/jfb13040301.

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Minimally-invasive surgery is rapidly growing and has become a standard approach for many operations. However, it requires intensive practice to achieve competency. The current training often relies on animal organ models or physical organ phantoms, which do not offer realistic surgical scenes or useful real-time feedback for surgeons to improve their skills. Furthermore, the objective quantitative assessment of endoscopic skills is also lacking. Here, we report a high-fidelity artificial urological system that allows realistic simulation of endourological procedures and offers a quantitative assessment of the surgical performance. The physical organ model was fabricated by 3D printing and two-step polymer molding with the use of human CT data. The system resembles the human upper urinary tract with a high-resolution anatomical shape and vascular patterns. During surgical simulation, endoscopic videos are acquired and analyzed to quantitatively evaluate performance skills by a customized computer algorithm. Experimental results show significant differences in the performance between professional surgeons and trainees. The surgical simulator offers a unique chance to train endourological procedures in a realistic and safe environment, and it may also lead to a quantitative standard to evaluate endoscopic skills.

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13

Jin, Yangwang, Weixin Zhao, Ming Yang, Wenzhuo Fang, Guo Gao, Ying Wang, and Qiang Fu. "Cell-Based Therapy for Urethral Regeneration: A Narrative Review and Future Perspectives." Biomedicines 11, no. 9 (August 24, 2023): 2366. http://dx.doi.org/10.3390/biomedicines11092366.

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Urethral stricture is a common urological disease that seriously affects quality of life. Urethroplasty with grafts is the primary treatment, but the autografts used in clinical practice have unavoidable disadvantages, which have contributed to the development of urethral tissue engineering. Using various types of seed cells in combination with biomaterials to construct a tissue-engineered urethra provides a new treatment method to repair long-segment urethral strictures. To date, various cell types have been explored and applied in the field of urethral regeneration. However, no optimal strategy for the source, selection, and application conditions of the cells is available. This review systematically summarizes the use of various cell types in urethral regeneration and their characteristics in recent years and discusses possible future directions of cell-based therapies.

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14

Xu, Kailei, Ying Han, Yuye Huang, Peng Wei, Jun Yin, and Junhui Jiang. "The application of 3D bioprinting in urological diseases." Materials Today Bio 16 (December 2022): 100388. http://dx.doi.org/10.1016/j.mtbio.2022.100388.

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15

Rabaud, M., J. Y. Elie, F. Lefebvre, D. Ducassou, P. Mettetal, M. Le Guillou, D. Collet, J. Périssat, D. Fradin, and F. Fontan. "A New Biodegradable Elastin-Fibrin Material; Its Use in Urological, Digestive and Cardiovascular Surgery." Journal of Biomaterials Applications 7, no. 1 (July 1992): 20–46. http://dx.doi.org/10.1177/088532829200700102.

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16

Jones, David S., Gavin P. Andrews, and Sean P. Gorman. "Characterization of crosslinking effects on the physicochemical and drug diffusional properties of cationic hydrogels designed as bioactive urological biomaterials." Journal of Pharmacy and Pharmacology 57, no. 10 (October 2005): 1251–59. http://dx.doi.org/10.1211/jpp.57.10.0003.

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17

Cho, Eui Ri, Sun-Woong Kang, and Byung-Soo Kim. "Poly(lactic-co-glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results." Journal of Biomedical Materials Research 72B, no. 1 (2004): 166–72. http://dx.doi.org/10.1002/jbm.b.30138.

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18

Lasaponara, F., G. Pasquale, G. Cucchiarale, and U. Ferrando. "Bladder Augmentation and Urinary Diversions in Kidney Transplants." Urologia Journal 76, no. 2 (April 2009): 90–94. http://dx.doi.org/10.1177/039156030907600208.

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There is some controversy about the safety of kidney transplant in patients with augmented or diverted urinary system: they are considered higher risk recipients in view of increased technical problems and infective complications leading to pyelonephritis and graft loss. The ureter of a transplanted kidney should be anastomosed into a reservoir with an adequate capacity, with low bladder pressure, with good compliance, and efficient voluntary empting. Ileal and sigmoid bladder augmentation, usually associated with clean intermittent catheterization, has become a well-accepted part of the urological practice and has been used for implantation of the transplant ureter. During the last years, the interest in new biomaterials for reconstructive surgery has increased. Experimental studies showed how these requests can be satisfied by porcine small intestinal submucosa SIS (Stratasis”): this can be degraded by the host and substituted by “new tissue”. In four recent cases we have used SIS to obtain an augmented, normal-pressure and good compliance bladder reservoir, with three (epithelial, muscular and adventitial) layers normally represented.

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19

Zhang, Yu, Jian He, Hechun Chen, and Chengdong Xiong. "A new hydrophilic biodegradable ureteral stent restrain encrustation both in vitro and in vivo." Journal of Biomaterials Applications 35, no. 6 (August 16, 2020): 720–31. http://dx.doi.org/10.1177/0885328220949376.

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Ureteral stents have been widely used as biomedical devices to treat some urological diseases for several decades. However, the encrustation complications hamper the long-time clinical use of the ureteral stents. In this work, a new type of biodegradable material for the ureteral stents, methoxypoly(ethylene glycol)-block-poly(L-lactide-ran-Ɛ-caprolactone) (mPEG-PLACL), is evaluated to overcome this problem. The results show that the hydrophilicity and degradation rate in artificial urine of mPEG-PLACL are both significantly increased. It is worth noting that the mPEG-PLACL shows a lower amount of encrustation after immersing the stents in the dynamic urinary extracorporeal circulation (DUEC) model for 7 days. In addition, 71% Ca and 92% Mg are inhibited in vivo by quantitative analysis. Pathological analysis exhibit that the mPEG-PLACL cause less diffuse mucosal hyperplasia after 7 weeks of implantation. All the results indicate that this new type of biodegradable material had an excellent potential for the ureteral stents in the future.

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20

Gilmore, Brendan F., Turlough M. Hamill, David S. Jones, and Sean P. Gorman. "Validation of the CDC biofilm reactor as a dynamic model for assessment of encrustation formation on urological device materials." Journal of Biomedical Materials Research Part B: Applied Biomaterials 9999B (2010): NA. http://dx.doi.org/10.1002/jbm.b.31567.

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21

Nowatzki, Paul J., Richard R. Koepsel, Paul Stoodley, Ke Min, Alan Harper, Hironobu Murata, Joseph Donfack, Edwin R. Hortelano, Garth D. Ehrlich, and Alan J. Russell. "Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings." Acta Biomaterialia 8, no. 5 (May 2012): 1869–80. http://dx.doi.org/10.1016/j.actbio.2012.01.032.

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22

Rebl, Henrike, Jürgen Renner, Wolfgang Kram, Armin Springer, Nele Fritsch, Harald Hansmann, Oliver W. Hakenberg, and J. Barbara Nebe. "Prevention of Encrustation on Ureteral Stents: Which Surface Parameters Provide Guidance for the Development of Novel Stent Materials?" Polymers 12, no. 3 (March 3, 2020): 558. http://dx.doi.org/10.3390/polym12030558.

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Encrustations of ureteral stents are one of the biggest problems with urological implants. Crystalline biofilms can occur alone or in combination with bacterial biofilms. To identify which surface parameters provide guidance for the development of novel stent materials, we used an in vitro encrustation system. Synthetic urine with increasing pH to simulate an infection situation was pumped over the polymer samples with adjusted flow rates at 37 °C to mimic the native body urine flow. Chemical surface features (contact angle, surface charge), as well as encrustations were characterized. The encrustations on the materials were analyzed quantitatively (dry mass) and qualitatively using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy (FTIR). The aim of this comparative study was to identify crucial surface parameters that might predict the quantity and type of mineral deposits in vitro and provide guidance for the development and screening of new polymer-based biomaterials for ureteral stent design. For the first time, we could identify that, within the range of our polymers, those materials with a slight hydrophilicity and a strong negative zeta potential (around −60 mV) were most favorable for use as ureteral stent materials, as the deposition of crystalline biofilms was minimized.

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23

Sharma, Swati, Anil Mandhani, Suryasarathi Bose, and Bikramjit Basu. "Dynamically crosslinked polydimethylsiloxane-based polyurethanes with contact-killing antimicrobial properties as implantable alloplasts for urological reconstruction." Acta Biomaterialia 129 (July 2021): 122–37. http://dx.doi.org/10.1016/j.actbio.2021.04.055.

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24

Tarawneh, Ola, Wasan Alwahsh, Hassan Abul-Futouh, Luma A. Al-Samad, Lama Hamadneh, Hadeel Abu Mahfouz, and Abdulqader Fadhil Abed. "Determination of Antimicrobial and Antibiofilm Activity of Combined LVX and AMP Impregnated in p(HEMA) Hydrogel." Applied Sciences 11, no. 18 (September 8, 2021): 8345. http://dx.doi.org/10.3390/app11188345.

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Catheter-associated urinary tract infections (CAUTIs) are nosocomial infections, causing more than one million cases per year. CAUTIs cause serious health issues; in addition, the cost of replacement of the device constrains the employment of urological devices. Therefore, there is an urgent need to develop novel biomaterials for use in catheters. In this study, poly hydroxyethyl-methacrylate p(HEMA) and drugs-loaded p(HEMA) with ampicillin trihydrate (AMP), levofloxacin (LVX), and drug combinations were prepared using free radical polymerization. The characterization of the dried films included the determination of glass transition temperature (Tg), ultimate tensile strength, elongation percentage, and Young’s modulus. Formulation toxicity, antimicrobial activity, and biofilm-formation ability were tested. Decreases in Tg value, U.T.S., and Young’s modulus, and an increase in elongation percentage were observed in AMP-loaded p(HEMA). Different ratios of drug combinations increased the Tg values. The films exhibited a cell viability higher than 80% on HEK 293 cells. Antimicrobial activity increased when p(HEMA) was loaded with LVX or a combination of LVX and AMP. Biofilm-forming ability reduced after the addition of antimicrobial agents to the films. p(HEMA) impregnated with AMP, LVX, and drug combinations showed significantly increased antimicrobial activity and decreased biofilm-forming ability compared with p(HEMA), in addition to the effects on (HEMA) mechanical properties.

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25

Becker, C., T. Laeufer, J. Arikkat та G. Jakse. "TGFβ-1 and epithelial-mesenchymal interactions promote smooth muscle gene expression in bone marrow stromal cells: Possible application in therapies for urological defects". International Journal of Artificial Organs 31, № 11 (листопад 2008): 951–59. http://dx.doi.org/10.1177/039139880803101105.

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Purpose For regenerative and cellular therapies of the urinary tract system, autologous bladder smooth muscle cells (SMCs) have several limitations, including constricted in vitro proliferation capacity and, more importantly, inability to be used in malignant conditions. The use of in vitro (pre-)differentiated multipotential adult progenitor cells may help to overcome the shortcomings associated with primary cells. Methods By mimicking environmental conditions of the bladder wall, we investigated in vitro effects of growth factor applications and epithelial-mesenchymal interactions on smooth muscle gene expression and on the morphological appearance of adherent bone marrow stromal cells (BMSCs). Results Transcription growth factor beta-1 (TGFβ-1) upregulated the transcription of myogenic gene desmin and smooth muscle actin-γ2 in cultured BMSCs. Stimulatory effects were significantly increased by coculture with urothelial cells. Prolonged stimulation times and epigenetic modifications further enhanced transcription levels, indicating a dose-response relationship. Immunocytochemical staining of in vitro-differentiated BMSCs revealed expression of myogenic protein α-smooth muscle actin and desmin, and changes in morphological appearance from a fusiform convex shape to a laminar flattened shape with filamentous inclusions similar to the appearance of bladder SMCs. In contrast to the TGFβ-1 action, application of vascular endothelial growth factor (VEGF) did not affect the cells. Conclusions The combined application of TGFβ-1 and epithelial-mesenchymal interactions promoted in vitro outgrowth of cells with a smooth muscle-like phenotype from a selected adherent murine bone marrow-derived cell population.

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26

Kundu, Anup K., Joel Gelman, and Darren R. Tyson. "Composite thin film and electrospun biomaterials for urologic tissue reconstruction." Biotechnology and Bioengineering 108, no. 1 (September 30, 2010): 207–15. http://dx.doi.org/10.1002/bit.22912.

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27

Casarin, Martina, Martina Todesco, Chiara Giulia Fontanella, Alessandro Morlacco, Fabrizio Dal Moro, and Andrea Bagno. "Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields." Processes 11, no. 7 (July 5, 2023): 2013. http://dx.doi.org/10.3390/pr11072013.

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Анотація:

The main purpose of tissue engineering is to fabricate and exploit engineered constructs suitable for the effective replacement of damaged tissues and organs to perfectly integrate with the host’s organism without eliciting any adverse reaction. Ideally, autologous materials represent the best option, but they are often limited due to the low availability of compatible healthy tissues. So far, one therapeutic approach relies on the exploitation of synthetic materials as they exhibit good features in terms of impermeability, deformability, and flexibility, but present chronic risks of infections and inflammations. Alternatively, biological materials, including naturally derived ones and acellular tissue matrices of human or animal origin, can be used to induce cells growth and differentiation, which are needed for tissue regeneration; however, this kind of material lacks satisfactory mechanical resistance and reproducibility, affecting their clinical application. In order to overcome the above-mentioned limitations, hybrid materials, which can be obtained by coupling synthetic polymers and biological materials, have been investigated with the aim to improve biological compatibility and mechanical features. Currently, the interest in these materials is growing, but the ideal ones have not been found yet. The present review aims at exploring some applications of hybrid materials, with particular mention to urological and cardiovascular fields. In the first case, the efforts to find a construct that can guarantee impermeability, mechanical resistance, and patency is herein illustrated; in the second case, the search for impermeability, hemocompatibility and adequate compliance is disclosed.

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28

&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 43, no. 2 (March 1997): 87. http://dx.doi.org/10.1097/00002480-199743020-00018.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 87A. http://dx.doi.org/10.1097/00002480-199803000-00319.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 87A. http://dx.doi.org/10.1097/00002480-199803000-00320.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 87A. http://dx.doi.org/10.1097/00002480-199803000-00321.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 88A. http://dx.doi.org/10.1097/00002480-199803000-00322.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 88A. http://dx.doi.org/10.1097/00002480-199803000-00323.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 88A. http://dx.doi.org/10.1097/00002480-199803000-00324.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 88A. http://dx.doi.org/10.1097/00002480-199803000-00325.

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&NA;. "MUSCULOSKELETAL PROSTHESES/UROLOGIC PROSTHESES." ASAIO Journal 44, no. 2 (March 1998): 89A. http://dx.doi.org/10.1097/00002480-199803000-00326.

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&NA;. "VASCULAR PROSTHESIS/ACCESS/UROLOGIC PROSTHESIS." ASAIO Journal 42, no. 2 (April 1996): 106–9. http://dx.doi.org/10.1097/00002480-199642020-00024.

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38

McManus, Michael C., Scott A. Sell, Whitney C. Bowen, Harry P. Koo, David G. Simpson, and Gary L. Bowlin. "Electrospun Fibrinogen-Polydioxanone Composite Matrix: Potential for in Situ Urologic Tissue Engineering." Journal of Engineered Fibers and Fabrics 3, no. 2 (June 2008): 155892500800300. http://dx.doi.org/10.1177/155892500800300204.

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Our objective is to demonstrate an electrospun fibrinogen-PDO (polydioxanone) composite scaffold will retain the superior cellular interaction of fibrinogen while producing a product with the functional strength needed for direct implantation. Fibrinogen-PDO composite scaffolds were electrospun with PDO ratios of 0% (pure fibrinogen), 10%, 20%, 30%, 40%, 50% and 100% (pure PDO) and disinfected using standard methods. Scaffolds were seeded with human BSM (bladder smooth muscle cells) and incubated with twice weekly media changes. Samples were removed at 7, 14 and 21 days for evaluation by collagen assay, scanning electron microscopy and histology. Cell seeding and culture demonstrated human BSM readily migrate throughout and remodel electrospun fibrinogen-PDO composite scaffolds with deposition of native collagen. Cell migration and collagen deposition increased with increasing fibrinogen concentration while scaffold integrity increased with increasing PDO concentration. Electrospun fibrinogen-PDO composite structures promote rapid cellular in-growth by human BSM while maintaining structural integrity. The fibrinogen to PDO ratio can be adjusted to achieve the desired properties required for a specific tissue engineering application. Our ultimate objective is to utilize this innovative biomaterial technology to produce an acellular, bioresorbable product that enables in situ tissue regeneration. While there is still much work to be done, these initial findings indicate fibrinogen-PDO composite scaffolds deserve further investigation.

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Luo, Hongbo, Xiuheng Liu, Tianpeng Wu, and Xiaobin Zhang. "Clinical application of percutaneous nephrostomy in some urologic diseases." Journal of Huazhong University of Science and Technology [Medical Sciences] 28, no. 4 (August 2008): 439–42. http://dx.doi.org/10.1007/s11596-008-0414-0.

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40

Babenko, S. P., and Andrey V. Badin. "ABOUT CALCULATION OF THE DETERMINISTIC EFFECT OF PROTEINURIA IN EMPLOYEES OF ENRICHMENT PLANTS OF NUCLEAR INDUSTRY." Hygiene and sanitation 97, no. 4 (April 15, 2018): 315–21. http://dx.doi.org/10.18821/0016-9900-2018-97-4-315-321.

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In this paper, we consider the impacts of gaseous uranium hexafluoride used at concentrating plants of the nuclear industry on the human body. The appearance of uranium hexafluoride in the air of the working premises is accompanied by hydrolysis and the formation of substances that can enter the human body and bring atoms of uranium and fluorine. The article describes the method of the determination of the working conditions preventing the development of occupational diseases in employees. The method is based both on the calculation of the number of toxic substances entering the human body in routine working conditions and comparison of this number with the threshold values for different deterministic effects. The proteinuria (protein content in urine) is selected as the considered deterministic effect. We used the published statistics on the threshold of the daily release from the human body toxic substances, long-entering the body in small doses and seem to be responsible for the occurrence of urologic diseases. The calculation was performed in the framework of a complex model describing the air pollution with products of hydrolysis of uranium hexafluoride entering of toxic substances in the human body, in working premises, as well as the passing of uranium and fluorine through the body. This model constructed by the authors of this article was described in previous publications. To ensure that the theoretical methods give the same results as the experimental, the results obtained by the standard method for employees of one of the enterprises of nuclear industry were compared with the data obtained using the theoretical method under the same working conditions. The considered theoretical method can complement and enrich the existing experimental methods for the identification of the onset of occupational diseases based on the sampling of different biomaterials from the employees working at enterprises.

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Lee, Seong Ho, Kyungtae Ko, Min Soo Choo, Won Ki Lee, Hyun Cheol Jeong, Sung Tae Cho, Sung Yong Kim, et al. "The effect and safety of polylactic acid and adipose-derived stromal vascular fraction cell as an injectable bulking agent in urologic field: A 24-week follow-up study." Journal of Biomedical Materials Research Part B: Applied Biomaterials 103, no. 2 (June 7, 2014): 440–47. http://dx.doi.org/10.1002/jbm.b.33221.

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42

Pochernikov, D. G., N. Т. Postovoytenko, L. V. Yakovleva, A. I. Strelnikov, and I. S. Kosterin. "Comparative analysis of the detectability of microorganisms in the prostatic fluid and ejaculate according to the results of bacteriological analysis." Andrology and Genital Surgery 22, no. 1 (April 22, 2021): 43–51. http://dx.doi.org/10.17650/1726-9784-2021-22-1-43-51.

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Introduction. Currently the chronic prostatitis (NIH type IV) remains insufciently studied and difcult to treat with antibiotics. When making the diferential diagnosis of chronic prostatitis it is generally accepted by the EAU and Russian guidelines that the detected microorganisms in the prostatic fuid and the ejaculate practically do not difer from each other. The tactics of treating patients with asymptomatic prostatitis by means of antibacterial drugs remains disputable. Most reputable authors believe that this category of patients shall receive treatment in case of infertility, pregnancy miscarriage or forthcoming surgery on the prostate gland. Recently, EAU guidelines have expressed doubts regarding the identity of the microbiota found in the prostatic secretions and the ejaculate.The study objective. Comparative analysis of the detectability of microorganisms in prostatic secretions and the ejaculate by means of bacteriological analysis among the men with chronic prostatitis of category IV.Materials and methods. The study involved 117 men who went to the urological clinic to pregravid examination or on the occasion of infertility. All patients were diagnosed with prostatitis of category IV based on a standard examination, and then a bacteriological analysis of prostatic secretions and ejaculate was performed. During the research the prostatic fuid and ejaculate were taken simultaneously and the analysis was carried out in one and the same bacteriological laboratory. In case the titer of the detected microorganisms was signifcant, the patients were ofered to undergo treatment without the use of antibiotics but with combination of bovhyaluronidase azoximer with prostate protectors and/or OM-89; after that a control bacteriological study was performed.Results. In the prostatic secretions and in the semen, the most commonly found gram-positive microorganisms were Staphylococcus spp. and Enterococcus spp.; the representatives of the Enterobacteriaceae were found less frequently. It was statistically proven that the titer of bacteria in the prostatic secretions was considerably higher than that in the ejaculate (p <0.01). Sterile cultures were statistically-proven to be more frequent in ejaculate compared with prostatic secretions (13.7 % vs 3.4 %, p <0.01). When analyzing the coincidences for bacteria, low concordance was obtained for all identifed microorganisms (gram-positive bacteria varied from 48.3 to 79.5 %, gram-negative bacteria varied from 57.1 to 80.0 %). After the combined therapy, the bacterial mass signifcantly decreased in the prostate secretion from 104.3 ± 1.6 CFU/ml to 103.3 ± 2.0 CFU/ml (p = 0.008), while in the semen the bacterial mass decreased from 103.5 ± 1.8 CFU/ml to 102.6 ± 2.1 CFU/ml (p = 0.02). In the prostatic secretions, there was a statistically-proven decrease in the number of gram-negative bacteria (p = 0.05). As soon as the treatment was completed all the patients demonstrated the normalized number of leukocytes according to microscopy of prostate secretions or spermogram.Conclusion. The ejaculate is a more sterile biomaterial compared with the prostatic fuid, which should be taken into account in the diferential diagnostics of the chronic prostatitis of category IV and MAGI. The use of non-antibacterial treatment regimens, such as bovhyaluronidase azoximer, prostate protectors and OM-89, can reduce the titer of bacteria to insignifcant values both in the prostatic secretions and in the semen; and in some cases make the ejaculate sterile.

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Berezhnoy, A. G., S. S. Dunaevskaya, and S. I. Auzina. "Ultrasound guided transrectal polyfocal biopsy in prostate cancer diagnosis." Russian Medical Inquiry 6, no. 6 (2022): 309–13. http://dx.doi.org/10.32364/2587-6821-2022-6-6-309-313.

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Background: prostate cancer (PCa) is a topic of special interest in the modern urologic oncology. PCa is associated with high rates of morbidity and mortality among the male population in Russia and worldwide. The current diagnostic algorithm for PCa detection includes a digital rectal examination to check the prostate, and a PSA test to measure levels of prostate specific antigen (PSA) in the blood, and a prostate biopsy followed by morphological verification. Aim: to analyze the results of transrectal ultrasound guided polyfocal biopsies of the prostate, performed from 2021 to 2022 in patients who underwent diagnosis and treatment at the Clinical Hospital "RZD-Meditsina" of the city of Krasnoyarsk. Patients and Methods: in all cases the evaluation of patients included the measurement of a total PSA (PSAtotal) concentration, standard examination, and the preparation for biopsy. The ultrasound guided prostate biopsy was performed in the hospital setting. After the procedure, all patients were followed up to control and prevent possible complications. Histological examination of the biomaterial included the verification of malignant neoplasms or benign lesions in the prostate tissue, Gleason score, and other morphological characteristics. Results: findings of 220 transrectal ultrasound guided prostate biopsies were analyzed. The median age of patients was 64 (44–89) years. Benign prostatic hyperplasia (BPH) was diagnosed in 112 (51%) patients, prostate cancer — in 108 (49%) patients. PSA level varied from 0.48 to 37.9 ng/ml in the BPH patients, and from 4.48 to 100.0 ng/ml in the PCa group. The median prostate volume was 74.61 (10.26–134.80) cm3 in the PCa group, and 153.45 (116.22–185.50) cm3 in the patients with BPH. Most of PCa patients had Gleason score ≤7 representing moderately differentiated tumors. Post-biopsy complications were observed in 141 (64.09%) patients and included hematuria, short-term rectal bleeding, chronic prostatitis exacerbation. All complications were cured successfully treated using conservative therapy. Conclusion: PCa can be diagnosed even in patients with low PSATotal levels or the normal prostate volume . Moderately differentiated tumors (Gleason score ≤7) predominated in the population of patients. These data are consistent with the effective early detection of PCa. Patients should be closely monitored in the early post-operative period after a diagnostic prostate biopsy to prevent potential complications. KEYWORDS: prostate cancer, biopsy, prostate, transrectal puncture biopsy, ultrasound navigation. FOR CITATION: Berezhnoy A.G., Dunaevskaya S.S., Auzina S.I. Ultrasound guided transrectal polyfocal biopsy in prostate cancer diagnosis. Russian Medical Inquiry. 2022;6(6):309–313 (in Russ.). DOI: 10.32364/2587-6821-2022-6-6-309-313.

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Williams, H. "In Vivo Responses to Urological Biomaterials as Utilized for Urological Reconstruction." UroToday International Journal, June 24, 2008. http://dx.doi.org/10.3834/uij.1939-4810.2008.06.102.

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45

Duan, Liwei, Zongliang Wang, Shuang Fan, Chen Wang, and Yi Zhang. "Research progress of biomaterials and innovative technologies in urinary tissue engineering." Frontiers in Bioengineering and Biotechnology 11 (August 14, 2023). http://dx.doi.org/10.3389/fbioe.2023.1258666.

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Substantial interests have been attracted to multiple bioactive and biomimetic biomaterials in recent decades because of their ability in presenting a structural and functional reconstruction of urinary tissues. Some innovative technologies have also been surging in urinary tissue engineering and urological regeneration by providing insights into the physiological behavior of the urinary system. As such, the hierarchical structure and tissue function of the bladder, urethra, and ureter can be reproduced similarly to the native urinary tissues. This review aims to summarize recent advances in functional biomaterials and biomimetic technologies toward urological reconstruction. Various nanofirous biomaterials derived from decellularized natural tissues, synthetic biopolymers, and hybrid scaffolds were developed with desired microstructure, surface chemistry, and mechanical properties. Some growth factors, drugs, as well as inorganic nanomaterials were also utilized to enhance the biological activity and functionality of scaffolds. Notably, it is emphasized that advanced approaches, such as 3D (bio) printing and organoids, have also been developed to facilitate structural and functional regeneration of the urological system. So in this review, we discussed the fabrication strategies, physiochemical properties, and biofunctional modification of regenerative biomaterials and their potential clinical application of fast-evolving technologies. In addition, future prospective and commercial products are further proposed and discussed.

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46

Lemons, J. E. "Areas of Need for Future Biomaterials Research." MRS Proceedings 55 (1985). http://dx.doi.org/10.1557/proc-55-127.

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ABSTRACTClinical treatment modalities have undergone very significant changes over the past 30 years, in part because of the development of new or improved synthetic substances (biomaterials) for the replacement of tissues. Most all aspects of medical care have been directly influenced. It is now possible to obtain biomaterials made from basic metallic, ceramic, carbonitic, or polymeric materials where the substance has been manufactured for a specific biomedical application. In past years, this was not possible and available industrial grade materials were often adapted or modified to accommodate applications in biological environments. These developments, along with the many other advances in both biomedical sciences and clinical applications, have provided an exciting situation with regard to the improvement of existing prostheses and materials or the development of new biomaterials for surgical implant devices. This presentation will summarize eight areas where defined needs for active biomaterials research continues, following an outline theme of: (1) the current clinical situation; (2) specific area of need; and (3) possible improvements through basic science and clinical research.This thematic presentation will consider the following general areas: (1) the minimization of interfacial wear and implant biodegradation with examples of total joint replacements and occlusal surfaces of teeth; (2) adhesives for soft and hard tissues with examples of total joint replacements, cements, cardiovascular and plastic surgery reconstructions; (3) percutaneous devices for orthopaedic, dental, cardiovascular, and general surgery; (4) bone and skin replacements for the treatment of major bone lesions and burns; (5) ligaments and tendons for joint and hand reconstructions; (6) spinal instruments for orthopaedic procedures; (7) conduits of various diameters for general and cardiovascular applications; and (8) valves for cardiovascular and urological procedures.

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Tarawneh, Ola, Hadeel Abu Mahfouz, Lama Hamadneh, Ahmad A. Deeb, Iyad Al-Sheikh, Wasan Alwahsh, and Abdulqader Fadhil Abed. "Assessment of persistent antimicrobial and anti-biofilm activity of p-HEMA hydrogel loaded with rifampicin and cefixime." Scientific Reports 12, no. 1 (March 10, 2022). http://dx.doi.org/10.1038/s41598-022-07953-3.

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AbstractCatheter-associated urinary tract infections (CAUTIs) are nosocomial infections causing more than one million hospital cases annually. The progress of CAUTIs leads to severe health complications. Infections result in blockage of the medical device due to biofilm formation, which necessitates the replacement of the device. The objective of this study is to improve urological biomaterials to minimize microbial growth and reduce the incidence of CAUTIs. Challenges from mixed biofilm are crucial and need to be addressed in the development of new coating materials. Herein, an investigation highlighted the reduction of mixed biofilm overgrowth and attachment tendency on poly-2-hydroxyethyl methacrylate (p-HEMA) surface by loading the hydrogel with rifampicin (RIF), cefixime trihydrate (CFX), and combined ratios of RIF and CFX. Mixed biofilm-formation ability in (3:1) RIF: CFX-loading p-HEMA (F6) surface showed best tendency to resist form biofilm. Persistent antimicrobial activity increased in p-HEMA loaded with combined ratios of RIF and CFX surface compared to p-HEMA alone, antimicrobial activity lasted for 8 days. All fabricated films exhibited %cell viability higher than 75% on HEK 293 cells. The addition of RIF and CFX may improve the duration of urological device employment before replacement.

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He, Peng, Qiang Dai, and Xiaojun Wu. "New insight in urological cancer therapy: From epithelial-mesenchymal transition (EMT) to application of nano-biomaterials." Environmental Research, March 2023, 115672. http://dx.doi.org/10.1016/j.envres.2023.115672.

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Liu, Kun, Nan Hu, Zhihai Yu, Xinzhou Zhang, Hualin Ma, Huawei Qu, and Changshun Ruan. "3D printing and bioprinting in urology." International Journal of Bioprinting, August 10, 2023, 0969. http://dx.doi.org/10.36922/ijb.0969.

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Three-dimensional (3D) printing with highly flexible fabrication offers unlimited possibilities to create complex constructs. With the addition of active substances such as biomaterials, living cells, and growth factors, 3D printing can be upgraded to 3D bioprinting, endowing fabricated constructs with biological functions. Urology, as one of the important branches of clinical medicine, covers a variety of organs in the human body, such as kidneys, bladder, urethra, and prostate. The urological organs are multi-tubular, heterogeneous, and anisotropic, bringing huge challenges to 3D printing and bioprinting. This review aims to summarize the development of 3D printing and bioprinting technologies in urology in the last decade based on the Science Citation Index-Expanded (SCI-E) in the Web of Science Core Collection online database (Clarivate). First, we demonstrate the search strategies for published papers using the keywords such as “3D printing,” “3D bioprinting,” and “urology.” Then, eight common 3D printing technologies were introduced in detail with their characteristics, advantages, and disadvantages. Furthermore, the application of 3D printing in urology was explored, such as the fabrication of diseased organs for doctor–patient communication, surgical planning, clinical teaching, and the creation of customized medical devices. Finally, we discuss the exploration of 3D bioprinting to create in vitro bionic 3D environment models for urology. Overall, 3D printing provides the technical support for urology to better serve patients and aid teaching, and 3D bioprinting enables the clinical applications of fabricated constructs for the replacement and repair of urologically damaged organs in future.

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Yu, Huan, Hengchong Shi, Ming Zhu, Xu Zhang, Lei Wang, Gongwei Tian, Lingjie Song, Shifang Luan, Dianpeng Qi, and Xiaodong Chen. "Salt Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti‐multiple Encrustations in Urological Devices." Advanced Healthcare Materials, February 28, 2023, 2203328. http://dx.doi.org/10.1002/adhm.202203328.

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