Дисертації з теми "Ultrasound drug delivery"
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Zderic, Vesna. "Ultrasound-enhanced ocular drug delivery /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8085.
Повний текст джерелаSutton, Jonathan T. "Tissue Bioeffects during Ultrasound-Mediated Drug Delivery." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234692.
Повний текст джерелаDiaz, de la Rosa Mario Alfonso. "High-frequency ultrasound drug delivery and cavitation /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1679.pdf.
Повний текст джерелаDiaz, Mario Alfonso. "High-Frequency Ultrasound Drug Delivery and Cavitation." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1050.
Повний текст джерелаMualem-Burstein, Odelia Wheatley Margaret A. "Drug loading onto polymeric contrast agents for ultrasound drug delivery /." Philadelphia, Pa. : Drexel University, 2008. http://hdl.handle.net/1860/2811.
Повний текст джерелаDwaikat, Mai Al. "The Effect of Ultrasound on Transdermal Drug Delivery." Thesis, Coventry University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492372.
Повний текст джерелаMitragotri, Samir. "Ultrasound-mediated transdermal drug delivery : mechanisms and applications." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/11263.
Повний текст джерелаFowler, Robert Andrew. "Inertial Cavitation with Confocal Ultrasound for Drug Delivery." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10024.
Повний текст джерелаAcoustic cavitation has been shown to be a useful tool in drug delivery for many different biological tissues and indications, and this thesis aims to contribute to the knowledge of cavitation from a drug delivery perspective. This thesis seeks to synthesize the current knowledge and practice concerning acoustic cavitation in a biomedical context, and to present a high intensity confocal ultrasound (US) prototype to address some of the current problems in the field and to give a proof of concept for the therapeutic efficacy of such a prototype. The thesis is organized in 5 chapters: 1. The use of acoustic cavitation in a biomedical context is presented here in a general review. This review comprises the state of the art for cavitation generation, experimental techniques currently being implemented for the measurement of cavitation, and the clinical and preclinical approaches to the use of cavitation in vivo on a tissue by tissue basis. 2. The high intensity confocal US prototype used for all studies in this thesis is presented here. It is characterized in terms of the advantages it gives for the generation of cavitation. Enhancement of cavitation is first demonstrated chemometrically with a fluorescent dosimeter compared to a single transducer at the ultrasonic focus. The mechanisms for cavitation enhancement are then investigated with acoustic measurements, linear pressure simulations, and high speed camera data. 3. The confocal US prototype in used in conjunction with a liposomal formulation of doxorubicin is performed in which a therapeutic enhancement of tumor inhibition is presented. The mechanism of this enhancement is investigated with liposomally encapsulated lanthanide contrast agents and magnetic resonance imaging. 4. A small scale proof of concept for the use of RNA interference using the confocal prototype, and liposomally encapsulated siRNA molecules. The experiments are performed In vivo with a xenograft of human breast tumor. This study also includes data for the safety of the US exposure on a mouse treated one time. 5. Another small scale proof of concept of the use of the confocal device on potentiating chemotherapy with the drug everolimus in a rat chondrosarcoma model. The studies presented here also investigate the use of multiple US exposures on the same tumor in a combined drug / US treatment regimen
Fowler, Robert Andrew. "Inertial Cavitation with Confocal Ultrasound for Drug Delivery." Electronic Thesis or Diss., Lyon 1, 2014. http://www.theses.fr/2014LYO10024.
Повний текст джерелаAcoustic cavitation has been shown to be a useful tool in drug delivery for many different biological tissues and indications, and this thesis aims to contribute to the knowledge of cavitation from a drug delivery perspective. This thesis seeks to synthesize the current knowledge and practice concerning acoustic cavitation in a biomedical context, and to present a high intensity confocal ultrasound (US) prototype to address some of the current problems in the field and to give a proof of concept for the therapeutic efficacy of such a prototype. The thesis is organized in 5 chapters: 1. The use of acoustic cavitation in a biomedical context is presented here in a general review. This review comprises the state of the art for cavitation generation, experimental techniques currently being implemented for the measurement of cavitation, and the clinical and preclinical approaches to the use of cavitation in vivo on a tissue by tissue basis. 2. The high intensity confocal US prototype used for all studies in this thesis is presented here. It is characterized in terms of the advantages it gives for the generation of cavitation. Enhancement of cavitation is first demonstrated chemometrically with a fluorescent dosimeter compared to a single transducer at the ultrasonic focus. The mechanisms for cavitation enhancement are then investigated with acoustic measurements, linear pressure simulations, and high speed camera data. 3. The confocal US prototype in used in conjunction with a liposomal formulation of doxorubicin is performed in which a therapeutic enhancement of tumor inhibition is presented. The mechanism of this enhancement is investigated with liposomally encapsulated lanthanide contrast agents and magnetic resonance imaging. 4. A small scale proof of concept for the use of RNA interference using the confocal prototype, and liposomally encapsulated siRNA molecules. The experiments are performed In vivo with a xenograft of human breast tumor. This study also includes data for the safety of the US exposure on a mouse treated one time. 5. Another small scale proof of concept of the use of the confocal device on potentiating chemotherapy with the drug everolimus in a rat chondrosarcoma model. The studies presented here also investigate the use of multiple US exposures on the same tumor in a combined drug / US treatment regimen
Phan, Tu-Ai Thi. "Novel host-guest systems for ultrasound-mediated drug delivery /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1459908051&sid=2&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерелаBian, Shuning. "Real-time monitoring of ultrasound and cavitation mediated drug delivery." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:e5a774a9-5b93-4862-8dd9-0614d234ff28.
Повний текст джерелаPereno, Valerio. "Characterisation of microbubble-membrane interactions in ultrasound mediated drug delivery." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:515f2c15-e9d3-46b8-875c-420084fbc9a3.
Повний текст джерелаWells, Aaron M. "The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2560.
Повний текст джерелаPodaru, George. "Exploring controlled drug release from magneto liposomes." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35544.
Повний текст джерелаDepartment of Chemistry
Viktor Chikan
This thesis focuses on exploring fast and controlled drug release from several liposomal drug delivery systems including its underlying mechanics. In addition, the construction of a pulsed high-voltage rotating electromagnet is demonstrated based on a nested Helmholtz coil design. Although lots of different drug delivery mechanisms can be used, fast drug delivery is very important to utilize drug molecules that are short-lived under physiological conditions. Techniques that can release model molecules under physiological conditions could play an important role to discover the pharmacokinetics of short-lived substances in the body. In this thesis, an experimental method is developed for the fast release of the liposomes’ payload without a significant increase in (local) temperatures. This goal is achieved by using short magnetic pulses to disrupt the lipid bilayer of liposomes loaded with magnetic nanoparticles. This thesis also demonstrates that pulsed magnetic fields can generate ultrasound from colloidal superparamagnetic nanoparticles. Generating ultrasound remotely by means of magnetic fields is an important technological development to circumvent some of the drawbacks of the traditional means of ultrasound generation techniques. In this thesis, it is demonstrated that ultrasound is generated from colloidal superparamagnetic nanoparticles when exposed to pulsed and alternating magnetic fields. Furthermore, a comparison between inhomogeneous and homogeneous magnetic fields indicates that both homogeneous and inhomogeneous magnetic fields could be important for efficient ultrasound generation; however, the latter is more important for dilute colloidal dispersion of magnetic nanoparticles. In strong magnetic fields, the ultrasound generated from the colloidal magnetic nanoparticles shows reasonable agreement with the magnetostriction effect commonly observed for bulk ferromagnetic materials. At low magnetic fields, the colloidal magnetic nanoparticle dispersion produces considerable amount of ultrasound when exposed to a.c. magnetic fields in the 20−5000 kHz frequency range. It is expected that the ultrasound generated from magnetic nanoparticles will have applications toward the acoustic induction of bioeffects in cells and manipulating the permeability of biological membranes
Tinkov, Steliyan. "Development of Ultrasound Contrast Agents for Targeted Drug and Gene Delivery." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-107213.
Повний текст джерелаSeto, Jennifer Elizabeth. "Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65765.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 159-167).
Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to overcome in a safe and reversible manner. One method for enhancing transdermal drug delivery involves the application of ultrasound (US) to skin to physically overcome the skin's barrier properties. To advance this method, the focus of this thesis has been to develop novel experimental strategies and data analyses that can be utilized in in vitro investigations of passive and US-enhanced transdermal drug delivery. US treatment is often combined with a chemical enhancer such as the surfactant sodium lauryl sulfate (SLS). The simultaneous application of US and SLS (referred to as US/SLS) to skin exhibits synergism in enhancing transdermal drug delivery and has been utilized in clinical settings. In order to study the delivery of therapeutic macromolecules into US/SLS-treated skin, e.g. vaccine delivery to the Langerhans cells or drug delivery to the blood capillaries near the epidermis-dermis junction, it would be desirable to conduct in vitro US/SLS-enhanced transdermal diffusion experiments using split-thickness skin (STS) models, in which much of the dermis is removed in order to simulate the in vivo transdermal diffusion to the desired skin component. Therefore, STS was evaluated as an alternative to the well-established US/SLStreated full-thickness skin (FTS) model for the delivery of hydrophilic permeants. The skin permeabilities and the aqueous pore radii of US/SLS-treated pig FTS, 700-pm-thick pig STS, human FTS, 700-pm-thick human STS, and 250-pm-thick human STS were compared over a range of skin electrical resistivity values. The US/SLS-treated pig skin models were found to exhibit similar permeabilities and pore radii, but the human skin models did not. Furthermore, the US/SLS-enhanced delivery of gold nanoparticles and quantum dots (two model hydrophilic macromolecules) was found to be greater through pig STS than through pig FTS, due to the presence of less dermis that acts as an artificial barrier to macromolecules. In spite of greater variability in correlations between STS permeability and resistivity, the results strongly suggest the use of 700-pm-thick pig STS to investigate the in vitro US/SLS-enhanced delivery of hydrophilic macromolecules. After the validation of the pig STS for US/SLS studies, this skin model was used to study the transdermal delivery of nanoparticles. While nanoparticles have potential as transdermal drug carriers, many studies have shown that nanoparticle skin penetration is limited. Therefore, the US/SLS treatment was evaluated as a skin pre-treatment method for enhancing the passive transdermal delivery of nanoparticles. Quantitative and qualitative methods (elemental analysis
(cont.) and confocal microscopy, respectively) were utilized to compare the delivery of 10-nm and 20- nm cationic, neutral, and anionic quantum dots into US/SLS-treated and untreated pig STS. The findings include: (a) ~0.01% of the quantum dots penetrated the dermis of untreated skin (which was quantified for the first time), (b) the quantum dots fully permeated US/SLS-treated skin, (c) the two cationic quantum dots studied exhibited different extents of skin penetration and dermal clearance, and (d) the quantum dot skin penetration is heterogeneous (which was determined using a novel application of confocal microscopy). Routes of nanoparticle skin penetration are discussed, as well as the application of the methods described herein to address conflicting literature reports on nanoparticle skin penetration in the context of nanoparticle skin toxicity. US/SLS treatment is concluded to significantly enhance quantum dot transdermal penetration by 500 - 1300%. The findings suggest that an optimum surface charge exists for nanoparticle skin penetration, and motivate the application of nanoparticle carriers to US/SLS-treated skin for enhanced transdermal drug delivery. The final investigation of this thesis focused on chemical penetration enhancers, which are used to enhance drug delivery through several biological membranes, particularly the stratum corneum of the skin. However, the fundamental mechanisms that govern the interactions between penetration enhancers and membranes are not fully understood. Therefore, the goal of this work was to identify naturally fluorescent penetration enhancers (FPEs) in order to utilize well-established fluorescence techniques to directly study the behavior of FPEs within the skin. In this study, 12 FPE candidates were selected and ranked according to their potency as skin penetration enhancers. The best FPEs found compared well to SLS, a well-known potent skin penetration enhancer. Based on the ranking of the FPEs, FPE design principles are presented. In addition, to illustrate the novel, direct, and non-invasive visualization of the behavior of FPEs within skin, three case studies involving the use of two-photon fluorescence microscopy are presented, including visualizing glycerol-mitigated and US-enhanced FPE skin penetration. Previous two-photon fluorescence microscopy studies have indirectly visualized the effect of penetration enhancers on skin by using a fluorescent permeant to probe the transdermal pathways of the penetration enhancer. These effects can now be directly visualized and investigated using FPEs. The combination of FPEs with fluorescence techniques represents a useful new approach for elucidating the mechanisms involved in penetration enhancement and membrane irritation, and for improving structure-activity relationships for penetration enhancers. The new physical insights obtained using FPEs will aid in designing effective penetration enhancers for drug delivery applications, including penetration enhancers to be combined with US for synergistically enhancing transdermal drug delivery. The experimental strategies presented in this thesis pave the way for investigations in several transdermal fields, including evaluating nanoparticle skin toxicity, designing nanoparticle drug delivery carriers, evaluating ultrasound-assisted transdermal vaccination, elucidating mechanisms of chemical penetration enhancer-induced skin irritation, designing topical formulations with penetration enhancers, and elucidating mechanisms of ultrasound and penetration enhancer synergism in enhancing skin permeability.
by Jennifer Elizabeth Seto.
Ph.D.
Xu, Doudou. "Targeted drug delivery with cyclodextrin-based nanocarriers and focused ultrasound triggering." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/e7aa1925-3553-48e4-90e7-dcccdf8f8c05.
Повний текст джерелаGourevich, Dana. "Ultrasound mediated Targeted Drug Delivery in vitro : design, evaluation and application." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/0a3943df-4330-44b5-9f06-814ba2379d11.
Повний текст джерелаHitchcock, Kathryn E. "Ultrasound-enhanced drug delivery in a perfused ex vivo artery model." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275922520.
Повний текст джерелаEisenbrey, John Wheatley Margaret A. "Ultrasound sensitive polymeric drug carriers for treatment of solid tumors /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3218.
Повний текст джерелаKushner, Joseph IV. "Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/38980.
Повний текст джерелаIncludes bibliographical references.
In the initial investigation of this thesis, Fick's second law of diffusion was modified to describe both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore channels. This new transport model, combined with dual radiolabeled diffusion experiments, was then used to separately evaluate how the porosity, the tortuosity, and the hindrance factor of the aqueous pore channels that exist in the skin varied as the extent of skin perturbation due to simultaneous treatment of the skin with low-frequency ultrasound (US) and a chemical enhancer, the surfactant sodium lauryl sulfate (SLS), and as the radius of the hydrophilic permeant delivered across the skin, were increased. This investigation revealed that the values of the hindrance factor and of the tortuosity decreased as the radius of the hydrophilic permeant increased, and that the value of the porosity of the aqueous pore channels increased as the extent of skin perturbation due to the application of US increased. This last result suggested that low-frequency US primarily enhances the transport of hydrophilic permeants by increasing the fraction of the skin surface occupied by the aqueous pore channels.
(cont.) This modeling approach was next applied to the passive delivery of hydrophobic permeants through the branched pathways located in the intercellular lipid bilayer domain of untreated stratum corneum (SC), the outermost layer of the skin. The existence of these branched pathways led to the development of a new theoretical model, the Two-Tortuosity Model, which requires two tortuosity factors to account for: 1) the effective diffusion path length, and 2) the total volume of the branched, intercellular transport pathways, both of which may be evaluated from known values of the SC structure. After validating the Two-Tortuosity model with simulated SC diffusion experiments in FEMLAB (a finite element software package), the vehicle-bilayer partition coefficient, Kb, and the lipid bilayer diffusion coefficient, Db, in untreated human SC were evaluated using this new model for two hydrophobic permeants, naphthol (Kb = 233 + 44, Db = 1.6*10-7 + 0.3*10-7 cm2/s) and testosterone (Kb = 100 + 14, Db = 1.8*10-8 + 0.2*10-8 cm2/s). This investigation demonstrated that the new proposed method to evaluate Kb and Db is more direct than previous methods, in which SC permeation experiments were combined with octanol-water partition experiments, or with SC solute release experiments, to evaluate Kb and Db.
(cont.) Previous studies on ultrasound-mediated transdermal drug delivery had hypothesized that the discrete regions which form on the surface of skin treated with low-frequency US in the presence of a colored permeant are regions of high permeability. To test this hypothesis, full-thickness pig skin was treated simultaneously with low-frequency US and SLS in the presence of a hydrophilic fluorescent permeant, sulforhodamine B (SRB), which was used to observe the location of the hypothesized localized transport regions (LTRs) and of the surrounding regions of US-treated skin (the non-LTRs). After US-pretreatment, diffusion masking experiments, a novel experimental method in which hydrophobic vacuum grease was selectively applied to the skin surface, demonstrated that the permeability of calcein, another hydrophilic fluorescent permeant, in the LTRs was -80-fold greater than in the non-LTRs. Furthermore, measurements of the skin electrical resistivity in both the LTRs and the non-LTRs revealed significant decreases relative to the skin electrical resistivity in untreated skin (-5000-fold and -170-fold, respectively), suggesting that two levels of significant structural perturbation exist in skin treated simultaneously with ultrasound and SLS.
(cont.) Finally, an analysis of the porosity-to-tortuosity ratio values suggested that transcellular transdermal transport pathways exist within the LTRs. To confirm the results of the previous investigation, the transdermal delivery of SRB and of rhodamine B hexyl ester (RBHE), a fluorescent hydrophobic permeant, in skin treated with low-frequency ultrasound (US) and/or a chemical enhancer (SLS) relative to untreated skin (the control) was analyzed with dual-channel two-photon microscopy (TPM). An analysis of the average fluorescence intensity profiles as a function of skin depth, obtained from the TPM images, revealed that SRB and RBHE penetrated beyond the stratum corneum and into the viable epidermis only in the LTRs of US-treated and of US/SLS-treated skin. Further analysis of the average fluorescence intensity profiles and of the enhancements in the vehicle-skin partition coefficient, the intensity gradient, and the effective diffusion path length confirmed that a chemical enhancer was required in the coupling medium during US-treatment to obtain two significant levels of increased penetration of SRB and RBHE into the skin.
(cont.) Finally, by comparing the heights and the widths of the fluorescence intensity peaks obtained from the dual-channel TPM images, the existence of transcellular pathways was confirmed in the LTRs of US-treated and of US/SLS-treated skin for SRB and RBHE, as well as in SLS-treated skin for SRB. In the final investigation of this thesis, the differences in the hindrance factor, the porosity, and the tortuosity of the aqueous pore channels located in the LTRs and in the non-LTRs were evaluated for the delivery of four hydrophilic permeants (urea, mannitol, raffinose, and inulin) using the transport model developed in the initial investigation of this thesis combined with dual radiolabeled diffusion masking experiments. In this analysis, three different idealized cases were examined. In the first case, where the porosity and the tortuosity were assumed to be independent of the permeant radius, the hindrance factor, and, therefore, the average pore radius, was found to be statistically larger in the LTRs than in the non-LTRs. In the second case, where a distribution of pore radii was assumed to exist in the skin, no meaningful results could be obtained due to the large variation in the shape of the distribution of pore radii used in the analysis.
(cont.) In the final case, where infinitely large aqueous pores were assumed to exist in the skin, the value of the porosity of the LTRs was found to be 3- to 8-fold larger than that of the non-LTRs, while there little difference was found in the values of the tortuosity of the LTRs and of the non-LTRs.
by Joseph Kushner, IV.
Ph.D.
Gerayeli, Faezeh. "Stimulated delivery of therapeutic molecules from hydrogels using ultrasound." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAS019/document.
Повний текст джерелаThe research described in this thesis is directed to study an externally stimulated DDS that incorporates a hydrogel as the matrix for the therapeutic agent. The research does not investigate a particular site for the delivery of the therapeutic agent. However, the aim of this research program is to develop various hydrogel formulations with desirable characteristics and structures from which the drug release can be controlled with applied external energy in the form of low-frequency ultrasound. To accomplish this, two types of natural hydrogels from agarose and chitosan and one type of synthetic hydrogel from PVA were fabricated. Parameters that affect the structure were varied for each type of hydrogel in order to study the effect of structural changes on drug loading and release capacity of hydrogels. Next, the obtained hydrogels were assessed for the delivery of Theophylline as the model drug.Among the three types of hydrogels, chitosan was found to have the fastest swelling rates and the higher water uptakes while the least swelling was found with PVA hydrogels and then agarose hydrogels crosslinked at pH 12. Regarding the mechanical stability of hydrogels, the ranking of the elastic modulus was PVA hydrogels (highest), then agarose hydrogels and chitosan copolymers (lowest). It seemed that the more mechanically stable structure of the PVA hydrogels correlated with a reduced mobility of water, in comparison to the greater mobility of water in the mechanically weaker chitosan copolymers.The stimulated and passive release of Theophylline from those hydrogel carriers showed how ultrasound, as an external energy, stimulates and controls the release of the drug. The measurements confirmed that it is only the energy imparted by the longitudinal ultrasonic waves that act on the polymeric network. The mechanism by which the ultrasound affects the release is considered as a form of a ratchet motor. The polymer chains play the role of the “ratchet” steps and the ultrasonic waves accelerate the particle movement in the release media. Hence, once the ultrasound is applied, the particles descend chain-to-chain (i.e. step-by-step) driven down their concentration gradient by the applied energy until they reach the surface of the hydrogel and hence are released into the surrounding media.Increasing the ultrasound intensity vastly accelerates the drug release. Indeed a higher intensity equals a higher energy transferred from the ultrasonic waves to the drug particles, resulting in faster and less controlled release. This also depends on the type of drug carrier structure. If the hydrogel carrier is mechanically stable, such as the PVA samples or the agarose hydrogels crosslinked at pH 12, the effect of high ultrasound intensity is much less compared to a less mechanically stable carrier such as the chitosan blends. Ultrasound applied for a longer period of time increases the amount of drug released, with the consequent effect of increasing the amount of heat generated in the hydrogel. Generally, a longer duration of the applied energy results in a greater amount of energy absorption, and an increase in friction and heat generation. These effects are important considerations in relation to the heat sensitivity of the drug to be delivered and the thermal characteristics of the polymeric carrier.This PhD research has demonstrated that both natural and synthetic hydrogels coupled to an ultrasonic energy source provides a controllable DDS, which provide some novel outcomes and contributions to the body of knowledge in the field of controlled drug delivery
Errico, Claudia. "Ultrasound sensitive agents for transcranial functional imaging, super-resolution microscopy and drug delivery." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC013.
Повний текст джерелаThis thesis focuses on two main branches of the application of ultrasound contrast agents: microbubbles-aided ultrafast ultrasound imaging of the brain and ultrasound-triggered drug delivery for cancer therapy. At first, gas-filled microbubbles have been used to retrieve the brain activation through the skull in large animais. With this approach we have been able to non-invasively reconstruct the cerebral network of the brain, as well as retrieve its hemodynamic response to specific evoked tasks with high spatiotemporal resolution. The validation of this novel functional ultrasound (fUS) imaging approach was facilitated by the high sensitivity of the ultrasensitive Doppler technique able to detect subtle hemodynamic changes due to the neurovascular coupling. These resuits suggested that combining microbubbles injections with ultrafast imaging may help to fully compensate for the attenuation from the skull. Indeed, by combining both, we preserved resolution and increased penetration depth. The injection of ultrasound contrast agents has also lead to outstanding resuits in ultrafast ultrasound imaging by breaking the diffraction barrier and move beyond the half-wavelength limit in resolution. We have demonstrated that cerebral microvessels of 9pm in diameter can me distinguished via ultrafast ultrasound localization microscopy (uULM). Millions of blinking sources were localized in space and in time in few seconds in a higher dimensional space, leading to super-resolved images (microbubble density map) of the whole rat brain with a spatial resolution of À/10. Moreover, a displacement vector allowed microbubbles-tracking within frames yielding to in-plane velocity measurements retrieving a large dynamic of cerebral blood velocities. Next, we have exploited how we can spatiotemporally control the vaporization of composite perfluorocarbon (PFC) microdroplets when their activation is triggered by short ultrasound pulses. The concept 'chemistry in-situ' is introduced as we have been able to control a spontaneous chemical reaction in-vitro. Moreover, a new microfluidic device in glass has been proposed to robustly produce monodisperse droplets for future in-vivo applications of the chemistry in situ. This new device presents 128-parallel generators with two pressurized rivers. Eventually, new ultrafast ultrasound monitoring sequences have been developed in order to control and monitor the release of composite droplets
Lattin, James R. "Ultrasound-Induced Phase Change of Emulsion Droplets for Targeted Gene and Drug Delivery." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3377.
Повний текст джерелаLyon, P. C. "Targeted release from lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4817361a-e7f8-4773-ac81-8445ace05301.
Повний текст джерелаHartley, Jonathan Michael. "Surface Modification of Liposomes Containing Nanoemulsions." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2846.
Повний текст джерелаHan, Tao. "Ultrasound and insertion force effects on microneedles based drug delivery : experiments and numerical simulation." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/19591.
Повний текст джерелаTHACKER, JAMES H. "SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160.
Повний текст джерелаLiu, Ying. "The impact of physical and biological factors on intracellular uptake, trafficking and gene transfection after ultrasound exposure." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43626.
Повний текст джерелаHallow, Daniel Martin. "Measurement and Correlation of Acoustic Cavitation with Cellular and Tissue Bioeffects." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19741.
Повний текст джерелаRodi, Abdalkader. "Development of novel phospholipids-based ultrasound contrast agents intended for drug delivery and cancer theranostics." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/217148.
Повний текст джерелаAlexandraki, Alexia. "Epigenetic drug delivery using ultrasound-mediated microbubble destruction as a potential treatment for colorectal cancer." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22420/.
Повний текст джерелаChen, Di. "Applications of Acoustic Techniques to Targeting Drug Delivery and Dust Removal Relevant to NASA Projects." ScholarWorks @ UVM, 2010. http://scholarworks.uvm.edu/graddis/44.
Повний текст джерелаDaftardar, Saloni B. "Ultrasound-mediated Topical Delivery of Econazole nitrate for Treating Raynaud’s Phenomenon." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1501501075880616.
Повний текст джерелаFurdella, Kenneth J., Russell S. Witte, and Geest Jonathan P. Vande. "Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy." SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 2017. http://hdl.handle.net/10150/624370.
Повний текст джерелаHutcheson, Joshua Daniel. "Quantification and control of ultrasound-mediated cell death modes." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/29768.
Повний текст джерелаCommittee Chair: Prausnitz, Mark; Committee Member: Bommarius, Andreas; Committee Member: Jones, Christopher; Committee Member: Sambanis, Athanassios. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Aryal, Muna. "Transient disruption of vascular barriers using focused ultrasound and microbubbles for targeted drug delivery in the brain." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104127.
Повний текст джерелаThe physiology of the vasculature in the central nervous system (CNS) which includes the blood-brain-barrier (BBB) and other factors, prevents the transport of most anticancer agents to the brain and restricts delivery to infiltrating brain tumors. The heterogeneous vascular permeability in tumor vessels (blood-tumor barrier; BTB), along with several other factors, creates additional hurdles for drug treatment of brain tumors. Different methods have been used to bypass the BBB/BTB, but they have their own limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Magnetic Resonance Imaging guided Focused Ultrasound (MRIgFUS), when combined with circulating microbubbles, is an emerging noninvasive method to temporarily permeabilize the BBB and BTB. The purpose of this thesis was to use this alternative approach to deliver chemotherapeutic agents through the BBB/BTB for brain tumor treatment in a rodent model to overcome the hinderances encountered in prior approaches tested for drug delivery in the CNS. The results presented in thesis demonstrate that MRIgFUS can be used to achieve consistent and reproducible BBB/BTB disruption in rats. It enabled us to achieve clinically-relevant concentrations of doxorubicin (~ 4.8±0.5 µg/g) delivered to the brain with the sonication parameters (0.69 MHz; 0.55 MPa; 10 ms bursts; 1 Hz PRF; 60 s duration), microbubble concentration (Definity, 10 µl/kg), and liposomoal doxorubicin (Lipo-DOX) dose (5.67 mg/kg) used. The resulting doxorubicin concentration was reduced by 32% when the agent was injected 10 minute after the last sonication. Three weekly sessions of FUS and Lipo-DOX appeared to be safe in the rat brain, despite some minor tissue damage. Importantly, the severe neurotoxicity seen in earlier works using other approaches does not appear to occur with delivery via FUS-BBB disruption. The resuls from three weekly treatments of FUS and Lipo-DOX in a rat glioma model are highly promising since they demonstrated that the method significantly inhibits tumor growth and improves survival. Animals that received three weekly sessions of FUS + Lipo-DOX (N = 8) had a median survival time that was increased significantly (P<0.001) compared to animals who received Lipo-DOX only (N = 6), FUS only (N = 8), or no treatment (N = 7). Median survival for animals that received FUS + Lipo-DOX was increased by 100% relative to untreated controls, whereas animals who received Lipo-DOX alone had only a 16% improvement. Animals who received only FUS showed no improvement. No tumor cells were found in histology in 4/8 animals in the FUS + Lipo-DOX group, and only a few tumor cells were detected in two animals. Tumor doxorubicin concentrations increased monotonically (823±600, 1817±732 and 2432±448 ng/g) in the control tumors at 9, 14 and 17 days respectively after administration of Lipo-DOX. With FUS-induced BTB disruption, the doxorubicin concentrations were enhanced significantly (P<0.05, P<0.01, and P<0.0001 at days 9, 14, and 17, respectively) and were greater than the control tumors by a factor of two or more (2222±784, 3687±796 and 5658±821 ng/g) regardless of the stage of tumor growth. The transfer coefficient Ktrans was significantly (p<0.05) enhanced compared to control tumors only at day 9 but not at day 14 or 17. These results suggest that FUS-induced enhancements in tumor drug delivery for Lipo-DOX are relatively consistent over time, at least in this tumor model. These results are encouraging for the use of large drug carriers, as they suggest that even large/late-stage tumors can benefit from FUS-induced drug enhancement. Corresponding enhancements in Ktrans were found variable in large/late-stage tumors and not significantly different than controls, perhaps reflecting the size mismatch between the liposomal drug (~100 nm) and Gd-DTPA (molecular weight: 938 Da). Overall, this thesis research provides pre-clinical data toward the development of MRIgFUS as a noninvasive method for the delivery of agents such as Lipo-DOX across the BBB/BTB to treat patients with diseases of the central nervous system
Thesis (PhD) — Boston College, 2014
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Physics
Owen, J. W. "Magnetic microbubbles : investigation and design of new formulations for targeted therapy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:47537fb2-76e2-4e84-94bf-1530c57ff25a.
Повний текст джерелаWilliams, Jacob Brian. "Nanoemulsions Within Liposomes for Cytosolic Drug Delivery to Multidrug-Resistant Cancer Cells." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6211.
Повний текст джерелаAppold, Lia [Verfasser], Andrij [Akademischer Betreuer] Pich, Twan [Akademischer Betreuer] Lammers, and Lothar [Akademischer Betreuer] Elling. "A polymeric microbubble platform for ultrasound-mediated drug delivery / Lia Appold ; Andrij Pich, Twan Lammers, Lothar Elling." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1194066518/34.
Повний текст джерелаSolorio, Luis Jr. "Application of Ultrasound Imaging for Noninvasive Characterization of Phase Inverting Implants." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1332258338.
Повний текст джерелаWischhusen, Jennifer. "Ultrasound Microbubbles for Molecular Imaging and Drug Delivery : detection of Netrin-1 in Breast Cancer & Immunomodulation in Hepatocellular Carcinoma." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1317/document.
Повний текст джерелаUltrasound molecular imaging uses microbubbles as ultrasound contrast agents which are functionalized with targeting ligands. Upon intravenous injection, targeted microbubbles bind to molecular markers presented on the tumor endothelium and enable the non-invasive assessment cancer-related biomarkers. In the present thesis, ultrasound molecular imaging was developed for detection of netrin-1, which is upregulated in 70% of metastatic breast cancer and promotes cell survival. A newly developed netrin-1 interference therapy requires the identification of patients who overexpress the target protein and, could benefit from anti-netrin-1 therapy. In vivo imaging of netrin-1 showed a significantly increased imaging signal in netrin-1-positive breast tumors compared to netrin-1-negative breast tumors and normal mammary glands. The results suggest that ultrasound molecular imaging allows accurate detection of netrin-1 on the endothelium of netrin-1-positive tumors and has the potential to become a companion diagnostic for netrin-1 interference therapy in breast cancer patients.Ultrasound-targeted microbubble destruction triggers cavitation and sonoporation thereby permeabilizing the tissue and facilitating local drug delivery. Further, immune cell infiltration and tumor antigen release are induced and trigger anti-tumor immune responses. In the present thesis, ultrasound-targeted microbubble destruction-mediated delivery of anti-cancer microRNA-122 and anti-microRNA-21 is studied for immune response activation in hepatocellular carcinoma, in which the immune microenvironment is deregulated. Tumor lymph nodes showed pro-tumor cytokine downregulation and anti-tumor cytokine upregulation, suggesting an overall positive therapy response with regard to the tumor immunology. The results identified ultrasound-targeted microbubble destruction-mediated miRNA delivery as a potent immuno-modulatory therapeutic approach
Javadi, Marjan. "Novel Liposomes for Targeted Delivery of Drugs and Plasmids." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3879.
Повний текст джерелаWischhusen, Jennifer. "Ultrasound Microbubbles for Molecular Imaging and Drug Delivery : detection of Netrin-1 in Breast Cancer & Immunomodulation in Hepatocellular Carcinoma." Electronic Thesis or Diss., Lyon, 2017. http://www.theses.fr/2017LYSE1317.
Повний текст джерелаUltrasound molecular imaging uses microbubbles as ultrasound contrast agents which are functionalized with targeting ligands. Upon intravenous injection, targeted microbubbles bind to molecular markers presented on the tumor endothelium and enable the non-invasive assessment cancer-related biomarkers. In the present thesis, ultrasound molecular imaging was developed for detection of netrin-1, which is upregulated in 70% of metastatic breast cancer and promotes cell survival. A newly developed netrin-1 interference therapy requires the identification of patients who overexpress the target protein and, could benefit from anti-netrin-1 therapy. In vivo imaging of netrin-1 showed a significantly increased imaging signal in netrin-1-positive breast tumors compared to netrin-1-negative breast tumors and normal mammary glands. The results suggest that ultrasound molecular imaging allows accurate detection of netrin-1 on the endothelium of netrin-1-positive tumors and has the potential to become a companion diagnostic for netrin-1 interference therapy in breast cancer patients.Ultrasound-targeted microbubble destruction triggers cavitation and sonoporation thereby permeabilizing the tissue and facilitating local drug delivery. Further, immune cell infiltration and tumor antigen release are induced and trigger anti-tumor immune responses. In the present thesis, ultrasound-targeted microbubble destruction-mediated delivery of anti-cancer microRNA-122 and anti-microRNA-21 is studied for immune response activation in hepatocellular carcinoma, in which the immune microenvironment is deregulated. Tumor lymph nodes showed pro-tumor cytokine downregulation and anti-tumor cytokine upregulation, suggesting an overall positive therapy response with regard to the tumor immunology. The results identified ultrasound-targeted microbubble destruction-mediated miRNA delivery as a potent immuno-modulatory therapeutic approach
DATTA, SAURABH. "The Role of Cavitation in Enhancement of rt-PA Thrombolysis." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196034787.
Повний текст джерелаBhargava, Aarushi. "Dynamics of smart materials in high intensity focused ultrasound field." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97994.
Повний текст джерелаDoctor of Philosophy
Smart materials are a type of intelligent materials that have the ability to respond to external stimuli such as heat, light, and magnetic fields. When these materials respond, they can change their structural, thermodynamical, mechanical or chemical nature. Due to this extraordinary property, smart materials are being used in many applications including biomedical, robotic, space, microelectronics, and automobile industry. However, due to increased sensitivity and need for safety in many applications, a biologically safe, wireless, and efficient trigger is required to actuate these materials. In this dissertation, sound is used as an external trigger to actuate two types of smart materials: shape memory polymers (SMPs) and piezoelectric materials. SMPs have an ability to store a temporary (arbitrarily deformed) shape and return to their permanent shape when exposed to a trigger. In this dissertation, focused sound induced thermal energy acts as a trigger for these polymers. A novel concept of focused ultrasound actuation of SMP-based drug delivery capsules is proposed as a means to solve some of the challenges being faced in the field of controlled drug delivery. Piezoelectric materials have an ability to generate electric power when an external mechanical force is applied and vice versa. In this study, sound pressure waves supply the external force required to produce electric current in piezoelectric disks, as a method for achieving power transfer wirelessly. This study aims to solve the current problem of low efficiency in acoustic power transfer systems by focusing sound waves. This dissertation addresses the fundamental physics of high intensity focused ultrasound actuation of smart materials by developing comprehensive mathematical models and systematic experimental investigations, that have not been performed till now. The developed models enable an in-depth analysis of individual parameters including nonlinear material behavior, acoustic nonlinearity and resonance phenomena that affect the functioning of these smart systems. These mathematical frameworks also serve as groundwork for developing more complex systems.
Mukherjee, Prithiviraj. "Generation of Drug-loaded Echogenic Liposomes using Microfluidic Hydrodynamic Flow Focusing." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460731209.
Повний текст джерелаSMITH, DENISE ANNE BUSH. "In vitro Characterization of Echogenic Liposomes (ELIP) for Ultrasonic Delivery of Recombinant Tissue-type Plasminogen Activator (rt-PA)." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1214234148.
Повний текст джерелаChakravarty, Prerona. "Photoacoustic drug delivery using carbon nanoparticles activated by femtosecond and nanosecond laser pulses." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33842.
Повний текст джерелаStaples, Bryant J. "Pharmacokinetics of Ultrasonically-Released, Micelle-Encapsulated Doxorubicin in the Rat Model and its Effect on Tumor Growth." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1844.pdf.
Повний текст джерела