Добірка наукової літератури з теми "Ultrasons transcrâniens"
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Статті в журналах з теми "Ultrasons transcrâniens":
Aubry, J. F., L. Marsac, M. Pernot, B. Robert, A. L. Boch, D. Chauvet, N. Salameh, et al. "Ultrasons focalisés de forte intensité pour la thérapie transcrânienne du cerveau." IRBM 31, no. 2 (May 2010): 87–91. http://dx.doi.org/10.1016/j.irbm.2010.02.013.
Megdiche, H., R. Jeribi, T. Zidi, A. Ben Hassine, L. Belghith, and S. Touibi. "P-35 Place du doppler transcrânien dans la prise en charge de l’enfant drépanocytaire." Journal of Neuroradiology 32, no. 2 (March 2005): 93. http://dx.doi.org/10.1016/s0150-9861(05)83115-3.
Konan, Anhum, N’goran Kouamé, Ndogomo Méité, Assoumou Tanoh, and Anne-Marie N’goan-Domoua. "Intérêt de l’Échodoppler transcrânien dans la prise en charge de l’enfant drépanocytaire au CHU de Yopougon." Journal of Neuroradiology 47, no. 2 (March 2020): 113–14. http://dx.doi.org/10.1016/j.neurad.2020.01.041.
Rachdi, H., C. Gautier, X. Leclerc, J. Y. Gauvrit, and J. P. Pruvo. "CO-05 Apport de l’echodoppler couleur transcrânien avec injection de produit de contraste pour la détéction des anévrysmes intracrâniens." Journal of Neuroradiology 31, no. 2 (March 2004): 87–88. http://dx.doi.org/10.1016/s0150-9861(04)96892-7.
Дисертації з теми "Ultrasons transcrâniens":
Zarader, Pierre. "Transcranial ultrasound tracking of a neurosurgical microrobot." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS054.
With the aim of treating brain tumors difficult to access with current surgical tools, Robeauté is developing an innovative microrobot to navigate deep brain areas with minimal invasiveness. The aim of this thesis was to develop and validate a transcranial ultrasound-based tracking system for the microrobot, in order to be able to implement robotic commands and thus guarantee both the safety and the effectiveness of the intervention.The proposed approach consists in positioning three ultrasound emitters on the patient's head, and embedding an ultrasound receiver on the microrobot. Knowing the speed of sound in biological tissue and the skull thickness crossed, it is possible to estimate the distances from the emitters to the receiver by time-of-flight measurements, and to deduce its 3D position by trilateration. A proof of concept was first carried out using a skull phantom of constant thickness, demonstrating submillimeter localization accuracy. The system was then evaluated using a calvaria phantom whose thickness and speed of sound in front of each emitter were deduced by CT scan. The system demonstrated an mean localization accuracy of 1.5 mm, i.e. a degradation in accuracy of 1 mm compared with the tracking through the skull phantom of constant thickness, explained by the uncertainty brought by the heterogeneous shape of the calvaria. Finally, three preclinical tests, without the possibility of assessing localization error, were carried out: (i) a post-mortem test on a human, (ii) a post-mortem test on a ewe, (iii) and an in vivo test on a ewe.Further improvements to the tracking system have been proposed, such as (i) the use of CT scan-based transcranial ultrasound propagation simulation to take account of skull heterogeneities, (ii) the miniaturization of the ultrasound sensor embedded in the microrobot, (iii) as well as the integration of ultrasound imaging to visualize local vascularization around the microrobot, thereby reducing the risk of lesions and detecting possible pathological angiogenesis
Vignon, François. "Focalisation d' ultrasons par retournement temporel et filtre inverse : application à l' échographie transcrânienne." Paris 7, 2005. https://tel.archives-ouvertes.fr/tel-00010706.
Vignon, Francois. "Focalisation d'ultrasons par retournement temporel et filtre inverse, application à l'échographie transcrânienne." Phd thesis, Université Paris-Diderot - Paris VII, 2005. http://tel.archives-ouvertes.fr/tel-00010706.
Imbault, Marion. "Quantitative and functional ultrafast ultrasound imaging of the human brain." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC158/document.
The objective of this thesis was to explore the potential of human brain ultrasound imaging. Anatomy, blood flow and soft tissue stiffness have already been studied with ultrafast ultrasound imaging in humans and validated in several organs, such as, the breast and liver but not yet on the adult brain. The main limitation of transcranial ultrasound imaging is today the very strong skull-induced aberration artefact. Indeed, the bone, due to its composition, does not allow for ultrasound propagation as elsewhere in the human body. Therefore, this thesis was focused on the development of ultrafast ultrasound imaging for the evaluation of soft tissue stiffness and neurofunctional imaging in the adult human brain, during brain surgery to bypass the problem of skull aberration, and on an aberration correction technique for transcranial ultrasound imaging.We first provided several evidence of the benefit of using shear wave elastography during brain surgery. We also presented our new technique for 3D shear wave elastography using a matrix array in order to be able to overcome the limitations of 2D imaging and in particular to reduce the operator dependence.In a second phase, we demonstrated the capability of ultrasound to identify, map and differentiate in depth cortical regions of activation in response to a stimulus, both in awake patients and in anaesthetized patients. We have demonstrated that ultrasound neurofunctional imaging has the potential to become a comprehensive modality of neuroimaging with major benefits for intraoperative use. In a third part, we developed a new sound speed estimation (SSE) technique, based on a three-step technique that estimates the sound speed accurately corresponding to the illuminated medium. This technique was tested in ultrasound phantoms and in vivo in patient’s liver. In both cases, our method was able to find the sound speed corresponding to the medium. We demonstrated that SSE was related to the fat fraction. This analysis led to the conclusion that SSE was able to distinguish a healthy liver from a diseased liver with both biopsy and MRI as gold standard. Combined with the use of the Wood’s formula, we were even able to access a fat fraction measured by non-invasive ultrasound. Finally, by combining the phase, the amplitude and the sound speed estimation, we have developed a new aberration correction algorithm to perform transcranial ultrasound imaging. By performing numerical simulations, we obtained images that faithfully represented the medium (lateral position and depth) and characterized by one resolution and one contrast similar to those obtained with a punctual source in the medium
Errico, Claudia. "Ultrasound sensitive agents for transcranial functional imaging, super-resolution microscopy and drug delivery." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC013.
This thesis focuses on two main branches of the application of ultrasound contrast agents: microbubbles-aided ultrafast ultrasound imaging of the brain and ultrasound-triggered drug delivery for cancer therapy. At first, gas-filled microbubbles have been used to retrieve the brain activation through the skull in large animais. With this approach we have been able to non-invasively reconstruct the cerebral network of the brain, as well as retrieve its hemodynamic response to specific evoked tasks with high spatiotemporal resolution. The validation of this novel functional ultrasound (fUS) imaging approach was facilitated by the high sensitivity of the ultrasensitive Doppler technique able to detect subtle hemodynamic changes due to the neurovascular coupling. These resuits suggested that combining microbubbles injections with ultrafast imaging may help to fully compensate for the attenuation from the skull. Indeed, by combining both, we preserved resolution and increased penetration depth. The injection of ultrasound contrast agents has also lead to outstanding resuits in ultrafast ultrasound imaging by breaking the diffraction barrier and move beyond the half-wavelength limit in resolution. We have demonstrated that cerebral microvessels of 9pm in diameter can me distinguished via ultrafast ultrasound localization microscopy (uULM). Millions of blinking sources were localized in space and in time in few seconds in a higher dimensional space, leading to super-resolved images (microbubble density map) of the whole rat brain with a spatial resolution of À/10. Moreover, a displacement vector allowed microbubbles-tracking within frames yielding to in-plane velocity measurements retrieving a large dynamic of cerebral blood velocities. Next, we have exploited how we can spatiotemporally control the vaporization of composite perfluorocarbon (PFC) microdroplets when their activation is triggered by short ultrasound pulses. The concept 'chemistry in-situ' is introduced as we have been able to control a spontaneous chemical reaction in-vitro. Moreover, a new microfluidic device in glass has been proposed to robustly produce monodisperse droplets for future in-vivo applications of the chemistry in situ. This new device presents 128-parallel generators with two pressurized rivers. Eventually, new ultrafast ultrasound monitoring sequences have been developed in order to control and monitor the release of composite droplets
Tiran, Elodie. "Imagerie cérébrale et étude de la connectivité fonctionnelle par échographie Doppler ultrarapide chez le petit animal éveillé et en mouvement." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC174/document.
My work focuses on the application of fUS (functional ultrasound) imaging to preclinical brain imaging in small animals. The goal of my thesis was to turn this recent vascular brain imaging technique into a quantifying tool for cerebral state. The main objectives were to demonstrate the feasibility of fUS imaging in the non-anaesthetized small rodents and to move from rat model imaging to mouse model imaging –most used model for preclinical studies in neuroscience-, while developing the least invasive imaging protocols. First, I have developed a new ultrafast ultrasonic imaging sequence (Multiplane Wave imaging), improving the image signal-to-noise ratio by virtually increasing emitted signal amplitude, without reducing the ultrafast framerate. Then, I have demonstrated the possibility to use ultrafast Doppler ultrasound imaging to image both the mouse brain and the young rat brain, non-invasively and through the intact skull, without surgery or contrast agents injection. Next, I have developed an experimental setup, an ultrasound sequence and an experimental protocol to perform minimally invasive fUS imaging in awake and freely-moving mice. Finally, I have demonstrated the possibility to use fUS imaging to study the functional connectivity of the brain in a resting state in awake or sedated mice, still in a transcranial and minimally invasive way. fUS imaging and the combination of "mouse model" + "minimally invasive" + "awake animal" + "functional connectivity" represent a very promising tool for the neuroscientist community working on pathological animal models or new pharmacological molecules