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Дисертації з теми "Tumour associated carbohydrate"

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Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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1

Youakim, Adel. "Tumour- and differentiation-associated changes in the carbohydrate structure of glycoproteins from human colonic cells." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75826.

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Анотація:
The structure of the carbohydrate associated with glycoproteins was examined in various human colonic tumour cells in culture following incubation with labeled sugars. Glycopeptides obtained by pronase digestion of the cell surface glycoproteins of three human colon tumours (HCT-8R, CaCo-2, and HCT-15) were compared with those from cells (CCL 239) derived normal adult colon. The tumour cells contain large molecular weight fucose-labeled glycopeptides that are absent in the CCL 239 cells. The large molecular weight fucose- and glucosamine-labeled glycopeptides from HCT-8R cells contain mainly mild alkali labile O-linked oligosaccharides, whereas those isolated from CaCo-2 cells contain primarily N-linked polylactosaminoglycans which bind to Datura stramonium agglutinin-agarose and are sensitive to endo-$ beta$-galactosidase.
Differentiation of CaCo-2 cells to polarized cells containing brush border enzymes characteristic of enterocytes is accompanied by a decrease in the relative proportion of fucose- and glucosamine-labeled N-linked polylactosaminoglycans-containing glycopeptides. These polylactosaminoglycans are found on a restricted set of glycoproteins of M$ sb{ rm r}$ 100,000-130,000. In undifferentiated cells, these glycoproteins contain a greater proportion of polylactosaminoglycans than those from differentiated cells.
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2

Shi, Mengchao. "Design and Synthesis of a Novel Entirely Carbohydrate-Based Conjugate for Cancer Vaccine Development." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470412718.

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3

Kleski, Kristopher A. "Progress of Entirely Carbohydrate Conjugates in Cancer Immunotherapeutics – Syntheses and Developments." University of Toledo / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1586980386810219.

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4

Trabbic, Kevin R. "Approaches to Increase the Immunogenicity of Carbohydrate Antigens Using PS A1 and Subsequent Immunotherapies." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470330973.

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5

Yamazaki, Yuji. "Investigation on Chemical and Enzymatic Synthesis of Tumor Associated Carbohydrate Antigens Triggering Immune Responses." Kyoto University, 2019. http://hdl.handle.net/2433/242472.

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6

Zou, Jun. "Characterization of peptides and phage that bind galectin-3 selected from bacteriophage display libraries a study of the role of galectin-3 in metastasis-associated cancer cell adhesion /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4149.

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Анотація:
Thesis (Ph. D.)--University of Missouri-Columbia, 2005.
"December 2005" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.
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7

LIU, SI-XIAN, and 劉思嫺. "Preparation of Carbohydrate Polymers Containing Three Different Tumor-Associated Carbohydrate Antigens." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/2sgct7.

Повний текст джерела
Анотація:
碩士
輔仁大學
化學系
107
Preparation of styrene-type glycoconjugates monomers, containing tumor-associated carbohydrate antigens (TACAs), such as Tn (Ser- / Thr- type), TF and sTn were developed. Polymerization of these TACAs monomers with polystyrene framework by NMP (Nitroxide-mediated radical polymerization) were also studied. Tn antigens were synthesized by the glycosylation reactions of D-galactose derivative, as glycol donor and L-serine or L-threonine derivatives as glycol acceptors. The first glycosylation reaction was proceeded to get the glycoproteins building blocks. The α-anomer was separated, and then attached to styrene through a spacer of diethylene glycol amine. The Tn glycoconjugate monomers were polymerized successfully to afford Tn glycoconjugate glycopolymers. To prepare others antigens, several functional groups were protected. Attachments of the second carbohydrate moieties, such as D-galatose and sialic acid, were constructed by the second glycosylation reactions. These two antigens were synthesized by the same methods used in the synthesis of Tn monomers, and eventually afforded three different types of glycoconjugates monomers. Controlled living radical polymerization (CLRP) of these three Tn glycoconjugate monomers were studied to produce the random and block co-polymers. Resulting glycopolymers were analyzed by NMR and ATR-IR to confirm TACAs presented on the polystyrene backbone.
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8

Jan, Fan-Dan, and 詹凡丹. "Synthese and Immunogenicities of Tumor-Associated Carbohydrate Vaccines." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/02685009606746575616.

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9

Huang, Yu-Ching, and 黃郁清. "Synthesis of S-Linked GD3 Tumor-Associated Carbohydrate Antigen." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/92445270678667358695.

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10

LeClair, Christopher Arthur. "Advances towards synthesis of C-glycosyl tumor-associated carbohydrate antigens /." 2006. http://wwwlib.umi.com/dissertations/fullcit/3225946.

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11

TSAI, YUN-TZU, and 蔡芸慈. "Preparation of Glycopolymers Containing Tumor-associated Carbohydrate Antigens by Nitroxide-Mediated Polymerization." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/d54gk9.

Повний текст джерела
Анотація:
碩士
輔仁大學
化學系
106
Starting from D-galactose, the glycosyl donor was prepared within 4 steps. In contrast, the glycosyl acceptor consisting of diethylene glycol and styrene to carry out the glycosylation reaction. After the product is obtained, the azide group is converted into an NHAc group to obtain a glycolmonomer, and a different sugar ratio polymer is prepared by using the NMP polymerization. On the other hand, in order to synthesize a product that is closer to a authentic structures of Tn antigens, benzyl group was first protected by Fmoc-Ser- OH as an starting material on the carboxylic acid, followed by the glycosylation reaction with a glycosyl donor, then coupled with a spacer to obtain a Tn-containing glycolmonomer for polymerization. From the experimental results, it is inferred that the Fmoc protecting group may be cleaved at a high temperature for a long time, causing difficulty in the polymerization reaction. In order to improve this situation, we converted its protecting group to acetyl group to obtain a sugar monomer for NMP reaction. Currently, all glycolpolymers can be confirmed by 1H NMR and IR spectra. This study provides the first synthesis method for the preparation of Tn glycolmonomer, and is the first ever to produce Tn-containing glycolmonomer by NMP reaction.
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12

Li, Yanhong. "Towards fully synthetic anticancer vaccines synthesis of tumor associated carbohydrate antigens and development of carbohydrate-based anticancer vaccines /." 2004. http://purl.galileo.usg.edu/uga%5Fetd/li%5Fyanhong%5F200405%5Fphd.

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13

Chuang, Hong-Yang, and 莊宏揚. "Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/89939994362828728549.

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Анотація:
博士
國立臺灣大學
化學研究所
102
Prostate cancer is the most commonly diagnosed cancer among men and the RM2 antigen has been discovered as a member of an antigenic carbohydrates family that is highly expressed on prostate cancer cells. The novel antigen RM2 belongs to ‘‘ganglio-series’’and the ‘‘disialyl lacto-series type chain’’ groups. And the RM2 antigen was not been synthesized by chemical method before. In this thesis, we have successfully developed a [1+2+3] one-pot strategy to synthesize the RM2 antigen hexasaccharide that was proposed to be a prostate tumor antigen. The structure of the synthetic product was verified by NMR analysis and antibody binding assay using a glycan microarray. In addition, the synthetic antigen was conjugated to a mutated diphtheria toxin (DT, CRM197) with different copy numbers and adjuvant combination to form the vaccine candidates. After vaccination in mice, we used glycan microarrays to monitor their immune response, and the results indicated that when one molecule of DT was incorporated with 4.7 molecules of RM2 in average (DT-RM4.7) and adjuvanted with the glycolipid C34 exhibited the strongest anti-RM2 IgG titer. Moreover, the induced mouse antibodies mediated effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap.
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14

Grosso, Ana Sofia de Campos. "Molecular recognition of tumor-associated antigens by lectins and antibodies." Master's thesis, 2017. http://hdl.handle.net/10362/26262.

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Анотація:
Every living cell on Earth is covered by glycans. They are inserted in proteins and lipids by a posttranslational modification called glycosylation. Their recognition by specific receptors is translated into distinct biological signals. In cancer cells, a misregulation in expression and/or activity of glycosyltransferases, alters the mechanism of glycosylation, creating new glycan epitopes dubbed tumor-associated carbohydrate antigens (TACAs). These are recognized by various receptors, playing a major role in tumor immune responses and metastasis. To target cancer-associated glycan phenotype is crucial to disentangle the molecular recognition process that involves TACAs recognition and biosynthesis. Therefore, NMR techniques were employed to investigate distinct glycan-protein systems: i) the molecular interactions between a mucin-1 (MUC1) related Tn-glycopeptide mimetic containing a non-natural amino acid and distinct antibodies by saturation transfer-difference (STD-NMR); ii) the molecular interactions between galectin-3 (Gal-3) and TF-antigen (TF-Thr and TF-peptide), by heteronuclear single quantum coherence 1H,15N-HSQC titrations, STD-NMR and line broadening analysis and iii) the glycosylation of MUC1 tandem repeated protein (G1VT3S4APDT8RPAPGS14T15APPAH20)4 by GalNAc-T3 using 1H,15N-HSQC and STD-NMR. In i), the STD-NMR binding experiments show that all antibodies under study recognize the Tn-glycopeptide mimetic and point out structural differences that explain antibodies’ binding preferences. In ii), the 1H,15N-HSQC titrations experiments indicate that Gal-3 binds both TF-derivatives. The dissociation constant KD estimated for both through chemical shift analysis also shows the same range of affinity (275 μM and 413 μM for TF-antigen and TF-peptide, respectively). STD-NMR results demonstrate that the protons from galactose in the TF-moiety govern the recognition process of Gal-3. In iii), the 1H,15N-HSQC experiments of MUC1 in presence of GalNAc-T3 show that the enzyme has preference to glycosylate first the Thr at –GVTS-, followed by the residue Thr at –GSTA-. STD-NMR confirms the cooperative mechanism between the lectin and catalytic domain of GalNAc-T3.
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15

Mickael, Guillemineau. "Total Synthesis of the Tumor-Associated Carbohydrate Antigen Lewis A Lewis X Hexasaccharide and Selected Fragments." Thesis, 2012. http://hdl.handle.net/10214/3847.

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Анотація:
Carbohydrates constitute the most abundant class of natural products in the living world and they play various roles. They are notably involved in cell-cell interactions and immune reactions. It has been observed that tumor cells express, on their surface, unusual oligosaccharides named Tumor-Associated Carbohydrate Antigen (TACA). One TACA of interest to our research group is the Lewis A Lewis X hexasaccharide that is displayed on the surface of squamous lung carcinoma cells. Since carbohydrates are involved in immune reactions and can be recognized by antibodies, it becomes possible to design a carbohydrate-based vaccine against these tumor cells. This thesis describes the total synthesis of the TACA Lewis A Lewis X hexasaccharide and the preparation of two fragments: one tetra- and one pentasaccharide. These molecules were prepared as hexyl and aminohexylglycosides. In addition, the hexasaccharide was synthesized as a disulfide. This diversity of these synthons will allow conjugation to a protein, analysis by nuclear magnetic resonance techniques, and immobilization on gold of the antigen. Without doubt, this work is a significant contribution to the development of an anti cancer vaccine as it constitutes the first stage of the process.
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