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Статті в журналах з теми "Tumoroïdes dérivés de patients"
Dusetti, Nelson, and Juan Iovanna. "Organoïdes dérivés des adénocarcinomes pancréatiques." médecine/sciences 36, no. 1 (January 2020): 57–62. http://dx.doi.org/10.1051/medsci/2019259.
Повний текст джерелаJeny, F., J. F. Bernaudin, D. Valeyre, H. Nunes, C. Planès, and V. Besnard. "Effets de l’hypoxie sur les macrophages dérivés de monocytes sanguins de patients atteints de sarcoïdose." Revue des Maladies Respiratoires Actualités 12, no. 1 (January 2020): 152–53. http://dx.doi.org/10.1016/j.rmra.2019.11.334.
Повний текст джерелаChatelut, Étienne. "Pharmacologie des dérivés du platine : différences entre les trois composés et les facteurs de variabilité entre patients." Bulletin du Cancer 98, no. 11 (November 2011): 1253–61. http://dx.doi.org/10.1684/bdc.2011.1464.
Повний текст джерелаBacle, A., S. Thevenot, C. Grignon, M. Belmouaz, M. Bauwens, N. Venisse, V. Migeot, and A. Dupuis. "Exposition au bisphénol A et à ses dérivés chlorés chez les patients traités par hémodiafiltration en ligne." Néphrologie & Thérapeutique 12, no. 5 (September 2016): 326. http://dx.doi.org/10.1016/j.nephro.2016.07.093.
Повний текст джерелаAwadi, S. O., L. Lauerière, J. Prinseau, L. Moulonguet-Doleris, A. Baglin, E. Rouveix, and T. Hanslik. "Utilisation des dérivés nitrés chez les patients âgés de 65 ans et plus hospitalisés en médecine interne." La Revue de Médecine Interne 27, no. 5 (May 2006): 366–68. http://dx.doi.org/10.1016/j.revmed.2006.01.013.
Повний текст джерелаAlexandra, J. F., E. Pautas, I. Gouin-Thibault, A. Gouronnec, N. Le Strat, and V. Siguret. "Surdosages en AVK liés à la potentialisation de dérivés coumariniques par les antifongiques azolés utilisés par voie cutanée chez des patients âgés." La Revue de Médecine Interne 28 (June 2007): 61. http://dx.doi.org/10.1016/j.revmed.2007.03.087.
Повний текст джерелаFonrose, X., A. Chartier, N. Mathieu, N. Jourdil, G. Bessard, and B. Bonaz. "P.154 Ratio dérivés méthylés/6-TGN et génotypage de la TPMT dans le suivi pharmacologique des patients avec MICI sous thiopurines." Gastroentérologie Clinique et Biologique 33, no. 3 (March 2009): A95. http://dx.doi.org/10.1016/s0399-8320(09)72785-x.
Повний текст джерелаBaermann, X., F. Renai, E. Hinglais, and C. Vincent-Cassy. "Œdème aigu du poumon cardiogénique avec hypertension artérielle ; l’absence d’utilisation des dérivés nitrés aux urgences aggrave-t-elle le pronostic des patients ?" Journal Européen des Urgences 22 (June 2009): A209. http://dx.doi.org/10.1016/j.jeur.2009.03.038.
Повний текст джерелаZeller, Frederick P., Giselle Rivera, and Michelle Depot. "Tolerance to Organic Nitrates in Ischemic Heart Disease." Drug Intelligence & Clinical Pharmacy 21, no. 11 (November 1987): 857–64. http://dx.doi.org/10.1177/106002808702101101.
Повний текст джерелаSteichen, Clara, Sébastien Giraud, and Thierry Hauet. "Les organoïdes rénaux." médecine/sciences 35, no. 5 (May 2019): 470–77. http://dx.doi.org/10.1051/medsci/2019090.
Повний текст джерелаДисертації з теми "Tumoroïdes dérivés de patients"
Seitlinger, Joseph. "Optimisation d’un modèle d’organoïde de cancer du poumon vascularisé dérivé de patient à des fins de médecine de précision." Electronic Thesis or Diss., Strasbourg, 2022. http://www.theses.fr/2022STRAJ022.
Повний текст джерелаDespite numerous recent advances, lung cancer is the leading cause of cancer mortality worldwide. Every year, new therapeutic drugs are developed to fight this disease whose prognosis remains poor. The development of precision medicine should make it possible to improve its effectiveness. In this perspective, we have optimized an organoid model derived from lung cancer patients. In this work, we were able to show that our model is reproducible and that it mimics the patient's tumor. Finally, the formation of a vascular network at the level of the organoid is possible : it can infiltrate the formed organoid but can also grow from the organoid to infiltrate the microenvironment. The model that we put forward thus meets the specifications of a patient Avatar model. The tests of therapeutic drugs or irradiation that we are currently carrying out will allow us to define if this model is compatible with a future use in clinical practice to improve the management of patients diagnosed with lung cancer
Paré, Bastien. "Culture tridimensionnelle de fibroblastes dermiques, dérivés de patients, pour l'étude de la Sclérose Latérale Amyotrophique et l’identification de biomarqueurs." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/66410.
Повний текст джерелаAmyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disease. Presently, it is an incurable disease without any effective treatment and is characterised by selective degeneration of motor neurons in the central nervous system. The symptoms that most patients display include cramps, weakness and muscle atrophy of the hands and feet progressing to the forearms, shoulders and legs, eventually leading to complete paralysis. Nearly 90% of all ALS cases are sporadic, with no known cause. The other 10% of cases represent familial ALS and are associated to ALS-linked genes, such as SOD1, FUS/TLS, TARDBP, and C9ORF72. The skin is considered by some to be the biggest organ of the human body. It plays an important role in thermoregulation as well as vitamin D synthesis. Skin also acts as a natural barrier against environmental threats. It is comprised of the epidermis and the dermis, which are made of keratinocytes and fibroblasts, among other things. The non-cell autonomous toxicity paradigm in ALS has been well established. Outside of the central nervous system, skin fibroblasts could potentially be an important source of biomarkers. The work presented in this thesis demonstrates that skin cells, such as fibroblasts and keratinocytes, derived from ALS patients, allow for the study of different pathological aspects of the disease. The use of a tissue-engineered skin from ALS patients skin cells allows for detection and observation of extracellular matrix structure abnormalities, as well as mislocalization of TDP-43, previously only detected in the motor neurons of patients. Results from experiments associated with this study shed more light on skin fibroblasts, which appear to be a potential source of novel biomarkers. Their secretome can be purified using an optimized protocol leading to pure proteins without salt contamination coming from the cell culture media. As a result, exosomes are of great interest for the discovery of novel biomarkers for the diagnosis of ALS, for following its progression, and for the culture of fibroblast cells. When cultivated in a 3D-fashion, the secreted exosomes contain molecules enhancing cell proliferation and migration, as well as high amounts of extracellular matrix proteins. These extracellular vesicles also help to enhance wound healing in a tissue-engineered model made of skin fibroblasts and keratinocytes. Finally, the SOD1 protein, which is associated with the development of some familial ALS cases, should be considered a potential neuropathological biomarker of sporadic ALS. Cytoplasmic aggregates of the misfolded protein were detected in the motor neurons of sporadic patients, alongside familial ALS patients who were carriers of an SOD1 mutation. Overall, this work shows that skin cells represent an important and minimally invasive biological sample in the study of ALS. These cells are also of interest in the discovery of novel ALS biomarkers. Exosomes secreted by skin fibroblast cells in a 3D culture are important in cell proliferation and migration. They play a crucial role in extracellular matrix protein secretion. The results of this study show that exosomes, proven to be secreted by dermal fibrobasts when cultivated in a 3D fashion, may become as a primary source of biomarkers in ALS. Cytoplasmic aggregates of misfolded SOD1 in motor neurons of sporadic ALS patients could lead to the development of diagnostic tests with SOD1.
Bacle, Astrid. "Perturbateurs endocriniens et patients en insuffisance rénale chronique terminale : impact des techniques d'hémodialyse sur l'exposition au Bisphénol A et à ses dérivés chlorés." Thesis, Poitiers, 2017. http://www.theses.fr/2017POIT1406/document.
Повний текст джерелаThe health safety conditions for the practice of hemodialysis (HD) and hemodiafiltration (HDF) do not integrate the risks associated with micropollutants such as endocrine disruptors (ED). Dialysed patients are at risk of overexposure to Bisphenol A (BPA), a well-recognized ED, due to its occurrence in medical devices used during dialysis and to the risk of accumulation due to their renal impairment.In a first step we have confirmed BPA contamination in dialyzers and demonstrated, for the first time, that the water used in HD was a significant source of BPA contamination, via dialysate production. Furthermore, we highlighted the presence of chlorinated derivatives of BPA (ClxBPA), by-products of water chlorination known to have higher oestrogenic activity than BPA, in dialysis water. Then, We have demonstrated that HDF leads to a higher risk of exposure to ED than HD, via the contamination of the liquid of substitution perfused in patient. These results will allow manufacturers to take into account the risk of contamination to these ED as well as physicians and pharmacists involved in patient care.Very few data are available regarding the clinical impact of such exposition on dialysed patient and no study has included the risk arising from ClxBPA. Therefore, we have performed exposure biomarkers using ultra-sensitive analytical methods to determine BPA and ClxBPA concentration in urine and plasma. These biomarkers will allow studying the impact of different dialysis techniques on patient exposure to these ED
Hu, Amelie. "Caractérisation des cellules corticales et des neurones sensoriels primaires dérivés des cellules souches pluripotentes induites (iPSC) de patients atteints de l'ataxie de Friedreich, et validation de thérapies potentielles." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271051.
Повний текст джерелаDoctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished
Mianné, Joffrey. "Thérapie génique par CRISPR/Cas9 pour corriger des épithéliums bronchiques dérivés de cellules souches pluripotentes induites (iPSCs) de patients atteints de dyskinésie ciliaire primitive (DCP) : une preuve de concept." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT045.
Повний текст джерелаPrimary Ciliary dyskinesia (PCD) is a rare and heterogeneous genetic disorder affecting the structure and function of motile cilia. In the airway epithelium, impaired ciliary motion results in chronic airway infections responsible for progressive and definitive decline of lung functions. There is currently no effective treatment for PCD, and research is limited by the lack of convenient models to study this disease and investigate innovative therapies.In this context, the main goals of this thesis are: 1) to develop a new in vitro PCD model based on the directed differentiation of patient-derived or genetically-engineered induced pluripotent stem cells (iPSC) into multiciliated airway epithelium, and 2) to use this model to investigate the potential of an innovative CRISPR/Cas9 gene therapy approach.To this aim, we have derived two iPSC lines, one from an healthy individual and a second from a PCD patient harbouring compound heterozygous mutations in the CCDC40 gene. Using the “healthy” iPSC line and the CRISPR/Cas9 technology we have generated isogenic knock-out controls for three PCD genes including CCDC40, DNAH5 and MCIDAS. In parallel, using the CRISPR/Cas9 technology and the homology directed repair approach, we have corrected the patient-derived iPSC line. By applying our optimized differentiation protocol to these cell lines, we are efficiently generating functional multiciliated airway epithelium recapitulating the ciliary phenotypes in function of the genotype. Furthermore, this new model has allowed us to investigate the potential of a CRISPR/Cas9-mediated reframing gene therapy approach to rescue ciliary phenotype in the patient line.In conclusion, the new model developed in this work could represent a major tool for in vitro PCD modelling. This model will be of particular interest for investigating the feasibility and efficacy of personalized therapies directly on the relevant human tissue. Our pipeline could therefore accelerate the development and translation of new therapeutics for PCD and other lung diseases
Brengel-Pesce, Carine. "Virus de l'immunodéficience humaine de type 1 (VIH-1) et atteinte du système nerveux central : analyse génétique et biologique de variants viraux dérivés de patients atteints d'encéphalite à VIH-1." Université Joseph Fourier (Grenoble), 1997. http://www.theses.fr/1997GRE10048.
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