Добірка наукової літератури з теми "Tubular injuries"
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Статті в журналах з теми "Tubular injuries":
1
Kato, Takashi, Man Hagiyama, Yasutoshi Takashima, Azusa Yoneshige, and Akihiko Ito. "Cell adhesion molecule-1 shedding induces apoptosis of renal epithelial cells and exacerbates human nephropathies." American Journal of Physiology-Renal Physiology 314, no. 3 (March 1, 2018): F388—F398. http://dx.doi.org/10.1152/ajprenal.00385.2017.
Анотація:
Chronic kidney disease (CKD) is an important problem throughout the world, associated with the increase of blood urea nitrogen (BUN) and serum creatinine (sCre) and with renal tubular injuries. It is crucial to elucidate the molecular mechanisms of renal injuries to identify the new therapeutics and early diagnostic methods. We focused on cell adhesion molecule-1 (CADM1) protein. CADM1, its isoform SP4, is expressed in the epithelial cells of various tissues, including renal distal tubules, localized on the lateral cell membrane, mediates cell-cell adhesion via trans-homophilic binding, and interacts with various proteins. We previously reported that its expression was downregulated by post-proteolytic cleavage (α- and β-shedding) in pulmonary diseases. To investigate whether CADM1 α-shedding occurs in human nephropathies, we performed Western blotting and immunohistochemical analysis of specimens with arterionephrosclerosis (AS) and diabetic nephropathy (DN) from autopsied kidneys. CADM1 α-shedding was induced in AS and DN kidneys and derived from the decrease in full-length CADM1 (FL-CADM1) and increase of the COOH-terminal fragment (α-CTF). In particular, the reduced FL-CADM1 level was correlated with tubular and tubulointerstitial injuries and the increases in BUN and sCre levels. Apoptosis of renal tubular epithelial cells (TECs) was promoted in both nephropathies, and it was significantly correlated with the decrease in the FL-CADM1. Furthermore, FL-CADM1 knockdown by small interfering RNA downregulated anti-apoptotic Bcl-2 protein and promoted apoptosis of cultured renal TECs. The present study suggests that the reduction of FL-CADM1 leads to renal TEC apoptosis and could exacerbate renal tubular and tubulointerstitial injuries, which contribute to the development of CKD.
2
Guan, Yu, Daisuke Nakano, Lei Li, Haofeng Zheng, Akira Nishiyama, Ye Tian, and Lei Zhang. "Protease-Activated Receptor 1 Contributes to Microcirculation Failure and Tubular Damage in Renal Ischemia-Reperfusion Injury in Mice." BioMed Research International 2021 (February 23, 2021): 1–8. http://dx.doi.org/10.1155/2021/6665714.
Анотація:
Ischemia-reperfusion- (IR-) induced kidney injury is difficult to avoid during renal transplantation and robot-assisted partial nephrectomy. Renal IR injury is characterized by tubular damage, microcirculation failure, and inflammation, which coordinately augment renal injury; however, no specific treatment is available for these conditions. Protease-activated receptor-1 (PAR-1) and its ligand, thrombin, are involved in coagulation and were shown to be associated with epithelial cell injury. Here, we hypothesized that PAR-1 exaggerated renal IR-induced tubular cell damage and microcirculation failure and that pharmacological inhibition of PAR-1 by Q94 could prevent these injuries. Renal warm IR increased the expression of PAR-1 in the renal tubules. Q94 attenuated renal IR-induced changes and histopathological damage. Microcirculation failure analyzed by congestion in the histopathology and blood cell flow examined by intravital multiphoton microscopy were suppressed by Q94 treatment. Q94 also dramatically increased tubular cell proliferation despite the lower renal damage. Thrombin suppressed cell proliferation and induced apoptosis in the tubules; these effects were prevented by Q94 treatment. Taken together, PAR-1 was associated with renal IR injury. Inhibition of PAR-1 ameliorated injury possibly by improving renal microcirculation and tubular cell survival/proliferation.
3
Hosohata, Keiko, Denan Jin, Shinji Takai, and Kazunori Iwanaga. "Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis." International Journal of Molecular Sciences 19, no. 10 (October 16, 2018): 3186. http://dx.doi.org/10.3390/ijms19103186.
Анотація:
Urinary tract obstruction and the subsequent development of hydronephrosis can cause kidney injuries, which results in chronic kidney disease. Although it is important to detect kidney injuries at an early stage, new biomarkers of hydronephrosis have not been identified. In this study, we examined whether vanin-1 could be a potential biomarker for hydronephrosis. Male Sprague-Dawley rats were subjected to unilateral ureteral obstruction (UUO). On day 7 after UUO, when the histopathological renal tubular injuries became obvious, the vanin-1 level in the renal pelvic urine was significantly higher than that in voided urine from sham-operated rats. Furthermore, vanin-1 remained at the same level until day 14. There was no significant difference in the serum vanin-1 level between sham-operated rats and rats with UUO. In the kidney tissue, the mRNA and protein expressions of vanin-1 significantly decreased, whereas there was increased expression of transforming growth factor (TGF)-β1 and Snail-1, which plays a pivotal role in the pathogenesis of renal fibrosis via epithelial-to-mesenchymal transition (EMT). These results suggest that vanin-1 in the renal pelvic urine is released from the renal tubular cells of UUO rats and reflects renal tubular injuries at an early stage. Urinary vanin-1 may serve as a candidate biomarker of renal tubular injury due to hydronephrosis.
4
Huang, Liang-Ti, and Chung-Ming Chen. "Kidney Injuries and Evolution of Chronic Kidney Diseases Due to Neonatal Hyperoxia Exposure Based on Animal Studies." International Journal of Molecular Sciences 23, no. 15 (July 31, 2022): 8492. http://dx.doi.org/10.3390/ijms23158492.
Анотація:
Preterm birth interrupts the development and maturation of the kidneys during the critical growth period. The kidneys can also exhibit structural defects and functional impairment due to hyperoxia, as demonstrated by various animal studies. Furthermore, hyperoxia during nephrogenesis impairs renal tubular development and induces glomerular and tubular injuries, which manifest as renal corpuscle enlargement, renal tubular necrosis, interstitial inflammation, and kidney fibrosis. Preterm birth along with hyperoxia exposure induces a pathological predisposition to chronic kidney disease. Hyperoxia-induced kidney injuries are influenced by several molecular factors, including hypoxia-inducible factor-1α and interleukin-6/Smad2/transforming growth factor-β, and Wnt/β-catenin signaling pathways; these are key to cell proliferation, tissue inflammation, and cell membrane repair. Hyperoxia-induced oxidative stress is characterized by the attenuation or the induction of multiple molecular factors associated with kidney damage. This review focuses on the molecular pathways involved in the pathogenesis of hyperoxia-induced kidney injuries to establish a framework for potential interventions.
5
Gosling, Peter, and Anne J. Sutcliffe. "Proteinuria following Trauma." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 23, no. 6 (November 1986): 681–85. http://dx.doi.org/10.1177/000456328602300610.
Анотація:
Thirteen trauma patients admitted to a major injuries unit were classified according to their injury severity. Urinary excretion of total protein, albumin and gamma glutamyl transpeptidase (GGT) activity were assessed over the following 6 days. All patients showed an initial glomerular and tubular proteinuria during the first 24 h which subsided by the second post-trauma day. The excretion of total protein and albumin was positively correlated with injury severity. Those patients with the severest injuries showed a marked recurrent total proteinuria around days 3 to 4 post-trauma which exhibited features of a tubular lesion. The recurrent proteinuria peak coincided with peak levels of serum c-reactive protein (CRP).
6
Duffy, Patrick, Seán McMahon, Xi Wang, Shane Keaveney, Eoin D. O'Cearbhaill, Iban Quintana, Francisco J. Rodríguez та Wenxin Wang. "Synthetic bioresorbable poly-α-hydroxyesters as peripheral nerve guidance conduits; a review of material properties, design strategies and their efficacy to date". Biomaterials Science 7, № 12 (2019): 4912–43. http://dx.doi.org/10.1039/c9bm00246d.
7
Watanabe, Toru. "Kidney and Urinary Tract Involvement in Kawasaki Disease." International Journal of Pediatrics 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/831834.
Анотація:
Kawasaki disease (KD) is a systemic vasculitis and can develop multiple organ injuries including kidney and urinary tract involvement. These disorders include pyuria, prerenal acute kidney injury (AKI), renal AKI caused by tubulointerstitial nephritis (TIN), hemolytic uremic syndrome (HUS), and immune-complex mediated nephropathy, renal AKI associated with either Kawasaki disease shock syndrome or unknown causes, acute nephritic syndrome (ANS), nephrotic syndrome (NS), renal tubular abnormalities, renal abnormalities in imaging studies, and renal artery lesions (aneurysms and stenosis). Pyuria is common in KD and originates from the urethra and/or the kidney. TIN with AKI and renal tubular abnormalities probably result from renal parenchymal inflammation caused by T-cell activation. HUS and renal artery lesions are caused by vascular endothelial injuries resulting from vasculitis. Some patients with ANS have immunological abnormalities associated with immune-complex formation. Nephromegaly and renal parenchymal inflammatory foci are detected frequently in patients with KD by renal ultrasonography and renal scintigraphy, respectively. Although the precise pathogenesis of KD is not completely understood, renal vasculitis, immune-complex mediated kidney injuries, or T-cell immune-regulatory abnormalities have been proposed as possible mechanisms for the development of kidney and urinary tract injuries.
8
Futrakul, Narisa, and P. Futrakul. "Renal microvascular and tubular injuries in type II diabetic nephropathy." Kidney International 74, no. 3 (August 2008): 390. http://dx.doi.org/10.1038/ki.2008.173.
9
Taneda, Sekiko, Kazuho Honda, Kimiko Tomidokoro, Kenta Uto, Kosaku Nitta, and Hideaki Oda. "Eicosapentaenoic acid restores diabetic tubular injury through regulating oxidative stress and mitochondrial apoptosis." American Journal of Physiology-Renal Physiology 299, no. 6 (December 2010): F1451—F1461. http://dx.doi.org/10.1152/ajprenal.00637.2009.
Анотація:
The present study was designed to elucidate a possible mechanism of hyperglycemia-induced tubular injury and to examine a therapeutic potential of dietary eicosapentaenoic acid (EPA) for the prevention of diabetic kidney disease. Utilizing streptozotocin-induced diabetic mice, the extents of albuminuria and histological injuries were monitored at 2 wk after diabetic induction. Reactive oxygen species (ROS) production, apoptosis, and hypoxia in the kidney were evaluated by immunohistochemistry and Western blotting. An in vitro study was performed using rat proximal tubular cells (NRK-52E) to confirm the protective effect of EPA for methylglyoxal (MG)-induced ROS generation and staurosporine (STS)-induced mitochondrial apoptosis. The extents of albuminuria and histological tubular injuries were significantly lower in EPA-treated diabetic mice compared with untreated diabetic mice. The levels of lipid peroxidation product (4-hydroxy-2-nonenal), oxidative DNA damage (8-hydoxy-deoxyguanosine), and mitochondrial apoptosis (TUNEL, caspase-9, cleaved caspase-3, and cytochrome c release) in the tubular cells were also significantly lower in EPA-treated diabetic mice. Furthermore, hypoxia-inducible factor (HIF)-1α expression was significantly upregulated in the kidney tissues from EPA-treated mice compared with untreated diabetic mice. MG-induced ROS overproduction and STS-induced mitochondrial apoptosis in NRK-52E cells were significantly reduced by EPA treatment in vitro. These results indicated that the ROS generation and mitochondrial apoptosis were involved in hyperglycemia-induced tubular injury and EPA had a beneficial effect by suppressing ROS generation and mitochondrial apoptosis partly through augmentation of an HIF-1α response in diabetic kidney disease.
10
Xiong, Mingxia, Lei Jiang, Yang Zhou, Wenjing Qiu, Li Fang, Rouyun Tan, Ping Wen та Junwei Yang. "The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression". American Journal of Physiology-Renal Physiology 302, № 3 (1 лютого 2012): F369—F379. http://dx.doi.org/10.1152/ajprenal.00268.2011.
Анотація:
Most chronic kidney injuries inevitably progress to irreversible renal fibrosis. Tubular epithelial-to-mesenchymal transition (EMT) is recognized to play pivotal roles in the process of renal fibrosis. However, a comprehensive understanding of the pathogenesis of renal scar formation and progression remains an urgent task for renal researchers. The endogenously produced microRNAs (miRNAs), proved to play important roles in gene regulation, probably regulate most genes involved in EMT. In this study, we applied microarray analysis to investigate the expression profiles of miRNA in murine interstitial fibrotic kidneys induced by unilateral ureteral obstruction (UUO). It was found that miR-200a and miR-141, two members of the miR-200 family, were downregulated at the early phase of UUO. In TGF-β1-induced tubular EMT in vitro, it was also found that the members of the miR-200 family were downregulated in a Smad signaling-dependent manner. It was demonstrated that the miR-200 family was responsible for protecting tubular epithelial cells from mesenchymal transition by target suppression of zinc finger E-box-binding homeobox (ZEB) 1 and ZEB2, which are E-cadherin transcriptional repressors. The results suggest that downregulation of the miR-200 family initiates the dedifferentiation of renal tubules and progression of renal fibrosis, which might provide important targets for novel therapeutic strategies.
Дисертації з теми "Tubular injuries":
1
RUEGG, CHARLES EDWARD. "MECHANISMS UNDERLYING REGIOSELECTIVE ACUTE TUBULAR NECROSIS OF RENAL PROXIMAL TUBULAR SEGMENTS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184162.
Анотація:
The convoluted (CPT) and straight (SPT) portions of the renal proximal tubule are susceptible to injury by a wide variety of chemical agents. These agents often affect the CPT or SPT selectively by proposed mechanisms usually attributed to tubular concentration, blood flow delivery patterns and tubuloglomerular feedback responses within the intact kidney. The innate cellular responses to chemical exposures remain virtually unexplored. Hence, the basic goal of this research was to develop an in vitro system that was conducive to examining the innate cellular differences in susceptibility between the CPT and SPT following in vitro exposure to mercuric chloride (HgCl₂), potassium dichromate (K₂Cr₂O₇)$ or hypoxic conditions. A renal cortical slicing technique was developed for these studies to position the CPT and SPT within discrete regions of slices made perpendicular to the cortical-papillary axis. An incubation vessel that could maintain the morophological and biochemical viability of slices for at least 12 hr was also developed. The selective necrosis of CPT induced by K₂Cr₂O₇ or hypoxic exposure, and SPT induced by HgCl₂, observed in vivo was reproduced in renal cortical slices exposed in vitro. Innate cellular uptake mechanisms were then investigated since the tissue distribution of each metal was found to be most concentrated within their respective injured cell type. The transport of PAH, TEA, phosphate, sulfate, glutathione and cysteine were examined as potential mechanisms for selective accumulation of these metals. K₂Cr₂O₇ caused a dose-dependent reduction in the uptake rate of sulfate by cortical slices, while phosphate, PAH, and TEA uptake were unaffected. Although HgCl₂ has a high affinity for sulfhydryl groups its uptake as a complex to glutathione or cysteine was not enhanced. HgCl₂ also had no affect on the uptake rate of PAH or TEA even though both HgCl₂ and K₂Cr₂O₇ were able to reduce the steady state accumulation of these organic substrates.
2
SILBER, PAUL MICHAEL. "EARLY INDICATION AND PATHOGENESIS OF RENAL PROXIMAL TUBULE INJURY (ENZYMURIA)." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184097.
Анотація:
It is well known that a variety of toxicants can cause damage to the renal proximal tubule. However, the early pathogenesis of these deleterious interactions between a toxicant and this region of the nephron remain poorly understood. Thus, the purpose of this research was to attempt to answer three interrelated questions. First, what are the earliest changes in kidney function and structure after administration of tubule toxicants in vivo? Secondly, how do these structural/functional alterations change over time? Finally, are certain indicators of renal "dysfunction" more sensitive then others to the early stages of proximal tubule injury? The basic experimental approach consisted of injecting laboratory animals with a selective proximal tubule toxicant, and then collecting blood and/or urine at several timepoints after dosing; a variety of renal function indicators were evaluated at each of these timepoints. These included blood urea nitrogen (BUN), the glomerular filtration rate (GFR), and the excretion of glucose, protein, salts, glutathione, enzymes, and other endogenous molecules into the urine. At the termination of the exposure period the kidneys were evaluated histopathologically, and were also assayed for levels of specific enzymes and glutathione. Enzyme histochemistry was used to visualize changes in renal enzyme distribution, and protein electrophoretic methods permitted quantification of urinary proteins. These studies showed that specific markers of renal dysfunction were more sensitive to acute proximal tubule injury than other indicators. Specifically, the urinary excretion of proteins and the brush border membrane marker γ-glutamyl transpeptidase (GGT) were the best indicators of proximal tubule injury. Glucosuria, lysozymuria, and glutathionuria were all less sensitive markers, and changes in BUN or GFR were the poorest indicators of acute proximal tubule injury. These results indicated that the brush border membrane is one of the most susceptible regions of the proximal tubule to acute renal injury. Analysis of urinary protein electrophoresis patterns and kidney histopathology confirmed this hypothesis. This research also demonstrated the progression of the toxicant-tubule interaction over time, and showed that both tubule structure and function may be altered within minutes of administering a nephro-toxicant.
3
Rubira, Cláudio José [UNESP]. "Efetividade de antibióticos em pacientes com trauma de tórax submetidos à toracostomia tubular fechada: revisão sistemática e metanálise." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/91400.
Анотація:
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Cerca de um terço dos traumas de tórax necessitam de hospitalização, e a grande maioria destes pacientes é tratada com toracostomia tubular fechada. A principal morbidade associada a este procedimento é o empiema pleural. Devido aos possíveis índices de morbidade e mortalidade relacionados ao empiema pós- traumático e as implicações do uso irracional de antibióticos, acreditamos ser relevante a realização desta revisão sistemática. Objetivos: Avaliar a efetividade da administração de antibiótico na redução de empiema em pacientes com toracostomia tubular devido a trauma. Métodos: Revisão sistemática de ensaios clínicos aleatorizados, utilizando a metodologia Cochrane, através de busca eletrônica e manual. Foram incluídos pacientes com trauma de tórax isolado, submetidos a toracostomia tubular fechada, sem distinção de idade e sexo, incluídos nos estudos elegíveis, cuja intervenção foi a administração de antibióticos como tratamento preventivo comparado com placebo. Resultados: Foram selecionados 6 estudos totalizando 753 pacientes com trauma torácico isolado submetidos a toracostomia tubular fechada. A metanálise demonstrou efeito de tratamento superior dos antibióticos em relação ao placebo, tanto para o desfecho empiema, RR=0,18 (IC 95% 0,07 a 0,46) como para o desfecho pneumonia, RR= 0,43 (IC 95% 0,23 a 0,82). Conclusão: Antibióticos são efetivos para reduzir a frequência de empiema e pneumonia em pacientes com trauma de tórax isolado submetidos a toracostomia tubular fechada.
About a third of the thorax traumas need hospitalization, and the great majority of these patients is treated with closed tube thoracostomy. The main morbidity associated to this procedure is the pleural empyema. Due to the possible morbidity and mortality rates related to the empyema posttraumatic and the implications of the irrational use of antibiotics, we believed to be relevant the accomplishment of this systematic review. Objectives: to evaluate the effectiveness of the antibiotic administration in the empyema reduction in patients with tube thoracostomy trauma. Methods: Systematic review of randomized clinical trials, using the Cochrane methodology, through electronic and manual search. It was included patients with isolated thorax trauma, submitted to closed tube thoracostomy, without distinction of age and sex, included in the eligible studies, whose intervention was the administration of antibiotics as preventive treatment compared to placebo. Results: 753 patients with isolated thoracic trauma submitted to closed tube thoracostomy in 6 studies. The meta-analysis demonstrated superior effect of antibiotics treatment in relation to the placebo, as much for the outcome empyema, RR=0,18 (IC 95% 0,07 to 0,46) as for the outcome pneumonia, RR = 0,43 (IC 95% 0,23 to 0,82). Conclusion: Antibiotics are effective to reduce the pneumonia and empyema incidence in patients with trauma of isolated thorax submitted to closed tube thoracostomy.
4
Rubira, Cláudio José. "Efetividade de antibióticos em pacientes com trauma de tórax submetidos à toracostomia tubular fechada : revisão sistemática e metanálise /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/91400.
Анотація:
Resumo: Cerca de um terço dos traumas de tórax necessitam de hospitalização, e a grande maioria destes pacientes é tratada com toracostomia tubular fechada. A principal morbidade associada a este procedimento é o empiema pleural. Devido aos possíveis índices de morbidade e mortalidade relacionados ao empiema pós- traumático e as implicações do uso irracional de antibióticos, acreditamos ser relevante a realização desta revisão sistemática. Objetivos: Avaliar a efetividade da administração de antibiótico na redução de empiema em pacientes com toracostomia tubular devido a trauma. Métodos: Revisão sistemática de ensaios clínicos aleatorizados, utilizando a metodologia Cochrane, através de busca eletrônica e manual. Foram incluídos pacientes com trauma de tórax isolado, submetidos a toracostomia tubular fechada, sem distinção de idade e sexo, incluídos nos estudos elegíveis, cuja intervenção foi a administração de antibióticos como tratamento preventivo comparado com placebo. Resultados: Foram selecionados 6 estudos totalizando 753 pacientes com trauma torácico isolado submetidos a toracostomia tubular fechada. A metanálise demonstrou efeito de tratamento superior dos antibióticos em relação ao placebo, tanto para o desfecho empiema, RR=0,18 (IC 95% 0,07 a 0,46) como para o desfecho pneumonia, RR= 0,43 (IC 95% 0,23 a 0,82). Conclusão: Antibióticos são efetivos para reduzir a frequência de empiema e pneumonia em pacientes com trauma de tórax isolado submetidos a toracostomia tubular fechada.Abstract: About a third of the thorax traumas need hospitalization, and the great majority of these patients is treated with closed tube thoracostomy. The main morbidity associated to this procedure is the pleural empyema. Due to the possible morbidity and mortality rates related to the empyema posttraumatic and the implications of the irrational use of antibiotics, we believed to be relevant the accomplishment of this systematic review. Objectives: to evaluate the effectiveness of the antibiotic administration in the empyema reduction in patients with tube thoracostomy trauma. Methods: Systematic review of randomized clinical trials, using the Cochrane methodology, through electronic and manual search. It was included patients with isolated thorax trauma, submitted to closed tube thoracostomy, without distinction of age and sex, included in the eligible studies, whose intervention was the administration of antibiotics as preventive treatment compared to placebo. Results: 753 patients with isolated thoracic trauma submitted to closed tube thoracostomy in 6 studies. The meta-analysis demonstrated superior effect of antibiotics treatment in relation to the placebo, as much for the outcome empyema, RR=0,18 (IC 95% 0,07 to 0,46) as for the outcome pneumonia, RR = 0,43 (IC 95% 0,23 to 0,82). Conclusion: Antibiotics are effective to reduce the pneumonia and empyema incidence in patients with trauma of isolated thorax submitted to closed tube thoracostomy.
Orientador: Antônio José Maria Catâneo
Coorientador: Paulo Eduardo de Oliveira Carvalho
Banca: Tânia Ruiz
Banca: Olavo Ribeiro Rodriguês
Mestre
5
Niasse, Aïssata. "Rôle de STAT5 dans l’épithélium rénal." Electronic Thesis or Diss., Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2020SORUS441.pdf.
Анотація:
Au cours des maladies rénales, les facteurs tissulaires et en particulier épithéliaux sont capables de moduler les lésions rénales ainsi que le pronostic de la maladie. La voie de signalisation JAK/STAT (Janus kinase / Signal transducers and activators of transcription), classiquement décrite dans les cellules immunitaires, a été décrite récemment dans les cellules rénales intrinsèques. Pour la première fois, nous montrons ici l'activation intraépithéliale de novo de STAT5 chez l'Homme et au cours des lésions glomérulaires et tubulaires in vivo. De plus, la délétion de STAT5 dans l'épithélium glomérulaire ou tubulaire aggrave à la fois les lésions glomérulaires et tubulaires dans plusieurs modèles murins de maladies rénales. L'interleukine 15 (IL-15), un agoniste classique de la voie STAT5, augmente sa phosphorylation dans les podocytes in vitro, avec des effets similaires lorsqu'elle est administrée aux souris par voie systémique. L'IL-15 améliore la protéinurie dans la glomérulopathie toxique et les lésions tubulaires dans la néphropathie induite par le cisplatine en activant Bcl2 et en réduisant l'apoptose épithéliale. Activer la voie STAT5 dans l’épithélium rénal glomérulaire et tubulaire avec l'IL-15 pourrait constituer une cible thérapeutique prometteuse dans les maladies rénales humainesDuring kidney disease diverse tissue-specific pathways can regulate kidney injury and prognosis. The Janus Kinase/ signal transducers and activators of transcription (JAK/STAT) pathway, classically described in immune cells, have been recently described in intrinsic kidney cells. For the first time we show here de novo intraepithelial activation of STAT5 in both humans and in both glomerular and tubular injury in vivo. Additionally, STAT5 deficiency in either glomerular or tubular epithelium aggravates both glomerular and tubular injury in a range of experimental mouse models. Interleukin 15 (IL-15), a classical activator of STAT5, increases STAT5 phosphorylation in podocytes in vitro, with similar effects when administered to mice. IL-15 alleviates proteinuria in toxic glomerulopathy and prevents/mitigates tubular lesions in cisplatin-induced nephropathy by activating Bcl2 and reducing epithelial apoptosis. Targeting the kidney STAT5 epithelial pathway with IL-15 might offer therapeutic benefits for human kidney diseases
Книги з теми "Tubular injuries":
1
Turner, Neil. Mechanisms of progression of chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0136.
Анотація:
Three major hypotheses attempt to explain progressive kidney disease following diverse diseases and injuries. To varying degrees they can explain the observed risk factors for progression and the ability of interventions to lower risk. The hyperfiltration hypothesis argues that progression is due to stress on residual nephrons leading to injury and damage to remaining glomeruli. The toxicity of proteinuria hypothesis proposes that serum proteins or bound substances are toxic to tubular or tubulointerstitial cells. This sets up cycles of damage which lead to tubulointerstitial scarring. The podocyte loss hypothesis contends that proteinuria is simply a biomarker for damaged or dying podocytes, and that it is further podocyte loss that leads to progressive glomerulosclerosis. Renoprotective strategies might have direct effects on podocytes. Importantly these different hypotheses suggest different therapeutic approaches to protecting the function of damaged kidneys. Differences between repair mechanisms may explain why some injuries lead to recovery and others to progressive disease, and may suggest new targets for protective therapy.
2
Henderson, Lorna K., Brian J. Nankivell, and Jeremy R. Chapman. Chronic allograft dysfunction. Edited by Jeremy R. Chapman. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0286.
Анотація:
Despite improvements in short-term renal allograft survival, long-term survival has not appreciably changed. Excepting death with a functioning graft, most late graft loss results from chronic allograft dysfunction. Immune and non-immune-mediated injuries contribute to graft dysfunction over time, ultimately leading to a non-specific and irreversible histological end-point of fibrosis, tubular atrophy, and glomerulosclerosis. Screening and early identification of pathology is crucial to allow timely intervention in order to prevent permanent nephron damage and graft loss. This chapter outlines assessment of renal dysfunction following transplantation, defines the causes of chronic allograft failure, and their pathophysiology, and evaluates current therapeutic strategies used to improve or stabilize chronic allograft dysfunction.
Частини книг з теми "Tubular injuries":
1
Trump, Benjamin F., and Irene K. Berezesky. "Ion Deregulation in Injured Proximal Tubule Epithelial Cells." In Nephrotoxicity, 731–41. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2040-2_113.
2
Picken, M. M. "Monoclonal Gammopathies: Glomerular and Tubular Injuries." In Pathobiology of Human Disease, 2831–52. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386456-7.05411-3.
3
Parilovsky, Оlexander, and Ivan Yatsenko. "FORENSIC VETERINARY CHARACTERISTICS OF FRACTURES, FRACTURE DISLOCATIONS, DISLOCATIONS AND SUBLUXATIONS OF THE BONES IN THE ANIMAL SKELETONS QUALIFIED AS SEVERE INJURIES." In Priority areas for development of scientific research: domestic and foreign experience. Publishing House “Baltija Publishing”, 2021. http://dx.doi.org/10.30525/978-9934-26-049-0-42.
Анотація:
The article presents forensic veterinary characteristics of fractures, fracture dislocations, dislocations and subluxations of skeletal bones in animals classified as severe injuries, including open and closed fractures of the upper and lower jaws, which lead to inability to receive normal food and water after healing; fracture or fracture dislocation of one or more thoracic or lumbar vertebrae along with spinal cord dysfunction or in the presence of clinically established severe shock; fracture of the dorsal or ventral arch of the first cervical vertebra; fractures and fracture dislocations of arches from the second to the seventh cervical vertebrae, as well as fractures of the dentate gyrus of the second cervical vertebra, including or excluding violation of the integrity and function of the spinal cord; dislocations and subluxations of the cervical vertebrae with life-threatening phenomena; closed fractures of the hyoid bone, closed and open injuries of the endocrine glands, which are located in the neck (thyroid, parathyroid, thymus - in young animals) - with life-threatening phenomena; open fractures of the humerus, femur and tibia; pelvic fractures with life-threatening phenomena. These injuries are classified as severe due to the fact that they harm the health of the animal and are life-threatening at the time of infliction, or after a certain period of time. They lead to the emergence and development of life-threatening phenomena and without necessary and sufficient veterinary care may end in death. A bone fracture is a complete violation of its anatomical integrity. Fractures can be non-fragmentary with the division of the bone into two fragments, fragmentary, and traumatic epiphysiolysis (with separation of bone part). If traumatic dislocation is accompanied by a fracture of the articular end of the bone, this condition should be diagnosed as fracture dislocation. For forensic veterinary examination of animals in case of fractures of tubular bones, such important features as the type of deformation (displacement (cutting), bending, compression, torsion, tension), the direction of the fracture line, the depth of penetration of fragments, the place of application of fractures, differentiation of injury, establishing the characteristics of the subject, the sequence of injury and the mechanism of injury should be taken into account. The empirical basis of the study is the analysis of expert opinions on the results of forensic veterinary examinations on animal cruelty, conducted in the Bureau of Forensic Veterinary Research at Kharkiv State Zooveterinary Academy from 2010 to 2020, as well as at the laboratory of forensic research of the National Research Center “Institute of Forensic Science named after Professor M.S. Bokarius” of the Ministry of Justice of Ukraine from 2017 to 2020. The aim of the study was to provide forensic veterinary characteristics of fractures of the skeletal bones in animals qualified as serious injuries. Modern methods of scientific cognition are used, in particular: general scientific (system-structural analysis, logical-grammatical, modelling), as well as special (clinical and pathomorphological).
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Harris, Kevin P. G. "Proteinuria: Implications for Progression and Management." In Mechanisms and Clinical Management of Chronic Renal Failure, 146–72. Oxford University PressNew York, NY, 2000. http://dx.doi.org/10.1093/oso/9780192629333.003.0005.
Анотація:
Abstract It is a well established observation from both human and animal studies of renal disease, that once a degree of renal damage has occurred then the progression of kidney failure is inexorable, even if the original injurious process has resolved [1]. Such observations have led to the hypothesis that following renal damage of any aetiology a maladaptive response occurs in the remaining nephrons which results in their eventual destruction by a common pathogenic mechanism. In support of this, the histological appearance of the kidney in end-stage renal disease is similar whatever the initial cause of the renal injury; within the glomerulus there are localised areas of cellular proliferation, deposition of excess extracellular matrix (ECM) and there is collapse of the glomerular capillary. Within the interstitium there is tubular cell atrophy, a mononuclear cell infiltrate, fibroblast proliferation, and ECl\:1 deposition. These events lead to the replacement of the functioning renal tissue by scar tissue, and affects both the glomeruli and the tubulo-interstitium, culminating in glomerulosclerosis and tubulo-interstitial fibrosis, respectively.
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ware, J. Anthony. "Cellular Mechanisms of Angiogenesis." In Angiogenesis And Cardiovascular Disease, 30–59. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780195112351.003.0002.
Анотація:
Abstract Alterations in endothelial cell function occur not only as part of new vessel formation, but also wound healing. Small injuries to the endothelial cell monolayer heal by migration of adjacent endothelial cells into the wound; after they reattach to the underlying matrix, they then reenter the cell cycle and divide to replace the denuded cells. In angiogenesis, the first step under most circumstances is dissolution of the underlying matrix, brought about by release of proteases (e.g., collagenases and plasminogen activator) from the stimulated endothelial cells themselves or from cells or material admitted to the subendothelial space under conditions of heightened endothelial permeability. The cells detach from the matrix and migrate by crawling along the vascular bed, and eventually readhere. Endothelial cells adhere to the underlying matrix via a number of different receptors, which become expressed on their surface in greater numbers when the cells are growing. Once the cells reattach, they reenter the cell cycle, proliferate, and align themselves into capillary sprouts or tubules.
Тези доповідей конференцій з теми "Tubular injuries":
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Mercier, Melina, Corin Shirley, Shelby Stafford, Sydney Hitzke, Achu Byju, Chris Kevorkian, Michael Madigan, and Michael Philen. "Fluidic Flexible Matrix Composites for Volume Management in Prosthetic Sockets." In ASME 2014 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/smasis2014-7706.
Анотація:
Persons with transfemoral and transtibial protheses experience changes in the volume of their residual limb during the course of the day. These changes in volume unavoidably lead to changes in quality of fit of the prosthesis, skin irritations, and soft tissue injuries. The associated pain and discomfort can become debilitating by reducing one’s ability to perform daily activities. While significant advancements have been made in prostheses, the undesirable pain and discomfort that occurs due to the volume change is still a major challenge that needs to be solved. The goal of this program is to develop smart prosthetic sockets that can accommodate for volume fluctuations in the residual limb. In this research, fluidic flexible matrix composite wafers (f2mc) are integrated into the prosthetic socket for volume regulation. The f2mc’s are flexible tubular elements embedded in a flexible matrix. These tubular elements are connected to a reservoir, and contain an internal fluid such as air or water. Fluid flow between the tubes and reservoir is controlled by valves. The f2mc’s can achieve more than 300% increase in volume and potentially several orders of magnitude of change in stiffness. Experimental results for a prosthetic socket demonstrate that the flexible matrix composite wafers can achieve changes in volume when pressurized.
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Omar, Tarek A., Nabih E. Bedewi, and Azim Eskandarian. "Significant Severity Reduction of Side-Impact Injuries by Using ITS Airbags: FE Simulation and Severity Analysis." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-39083.
Анотація:
The Inflatable Tubular Structure (ITS) airbag is a potentially life-saving device that has been implemented recently in some luxury vehicles. Its main objective is to provide head protection for the front seat occupants against upper side-interior car components. In a previous research conducted by the authors, a nonlinear Finite Element (FE) model for the ITS-airbag system was successfully developed and tested. In the current research, the developed ITS model is combined with a full-scale FE vehicle model and 50th percentile side-impact dummy (SID) model. The combined model is then used to conduct two series of side-impact simulations. The first series included side impacts with narrow objects, i.e. rigid poles, while the second series included side impacts with a Moving Deformable Barrier (MDB) as a wide and deformable object. The effect of the relative position between the dummy and the rigid pole was considered by conducting variety of simulations for two different rigid pole positions and three different dummy positions. The three dummy positions were considered in the side impacts with the MDB. For both impact series, the effect of the impact velocity was considered by conducting each impact scenario at three different velocities. The ITS model performance, in all FE simulations, was fairly similar to the actual ITS performance. The simulation results indicated a significant reduction in the Head Injury Criteria (HIC) of the dummy head due to the ITS-airbag deployment. The life-threatening severity for occupants is usually measured by the Abbreviated Injury Scale (AIS) that ranges from 1 (minor) to 6 (fatal). The AIS indices are calculated in all side impacts. The results demonstrated a significant reduction/elimination in fatalities and severe injuries due to the ITS-airbag performance. The results clearly indicated the great benefits expected from this promising safety device.
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GUO, Da, Jian-min WANG, and Jian-ming OUYANG. "Injured Human Kidney Proximal Tubular Epithelial Cells Modulate Nucleation and Growth of Calcium Oxalate Crystals." In 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/bbe-17.2017.27.
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Bieber, Malte, Sarah Menzel, Anja Lena Thiebes, Christian Gabriel Cornelissen, Stefan Jockenhoevel, Reinhold Kneer, and Manuel Armin Reddemann. "Viability of coaxial atomization for disintegration of cell solutions in cell spray applications." In ILASS2017 - 28th European Conference on Liquid Atomization and Spray Systems. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/ilass2017.2017.4609.
Анотація:
Treating Leukemia with intravenous stem cell transplantation represents a well-established therapy technique. For applications, that require high local cell concentrations, transplantation by conventional intravenous injection is less potent, due to cell distribution with blood circulation. Instead, spraying them directly onto the injured or diseased area shows promising results in various applications, e.g. superficial treatment of topographically challenging wounds, in situ seeding of cells on implants, deposition of cells in tubular organs for stem cell therapy. The present work aims for a basic knowledge about viability boundaries for coaxial cell-spray atomization and the reciprocal influence between cells in solution and primary breakup mechanics. A generic modular nozzle is developed, to ensures reproducible boundary conditions. Investigations are conducted regarding primary breakup and relations between resulting droplet size distribution and cell survival. Measurements are performed, utilizing microscopic high-speed visualization with suitable image post processing. Cell viability is analyzed using phase contrast microscopy prior and after atomization. A relation between Rayleigh-Taylor instability wavelength and droplet size distributions by means of Sauter mean diameter (SMD) and cell survival rate (CSR) is suggested. A power law is presented, exclusively dependent on dimensionless measures (λ⊥ ∼ Re-1/2 We −1/3) which is found to be proportional to SMD and CSR.DOI: http://dx.doi.org/10.4995/ILASS2017.2017.4609
Звіти організацій з теми "Tubular injuries":
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Goel, Dr Divanshu, and Dr Manjeet Singh. HYBRID EXTERNAL FIXATION FOR PROXIMAL TIBIAL FRACTURES. World Wide Journals, February 2023. http://dx.doi.org/10.36106/ijar/1505336.
Анотація:
Introduction: Intraarticular fractures of the tibial plateau and periarticular fractures of the proximal tibia, caused by high energy trauma pose a therapeutic dilemma. Such fractures are associated with extensive soft tissue damage with or without compound injury. The management of such high velocity injuries become a challenge to the trauma surgeons. The goals of these periarticular fractures management are 1. Restoration of joint congruity by anatomic reduction 2. Stable xation of fractures thus allowing early movements 3. Proper care of injured soft tissues. In earlier days uniplanar external xation were used with various complications like pin track infections and decreased stability. In this study we present the use of hybrid external xation system which includes Ilizarov ring xator and AO rod external xator connected with indigenously manufactured connecting clamps and short shafts augmented with or without minimal internal xation. The purpose of this study is to assess the utility of this hybrid external xation system and to analyse the functional outcome, soft tissue healing and fracture union. To assess the performance of the Hybrid External Fixator Aim and Objective: in the treatment of different types of proximal tibial fractures, to evaluate the functional outcome, soft tissue healing and fracture union and radiological outcome, to evaluate the biomechanical and biological advantage of hybrid external xator, to assess the utility of the indigenously made connecting clamps. Material and Method: The study included 21 cases of periarticular fractures of the proximal tibia which were treated by use of 5/8th Ilizarov ring, AO tubular external xator and with indigenously manufactured connecting clamps & short shaft in a hybrid mode. All cases were prospectively followed up and studied. Almost all the cases (99%) had sustained Road trafc Accidents (high velocity injuries) except one case which had sustained injury by fall of cement wall over her leg. Minimum follow up – 1.5 months, maximum follow up – 12 months, mean follow up – 6.42 months. All fractures were followed according to a protocol. All fractures were treated with either CLOSED REDUCTION AND HYBRID EXTERNAL FIXATION OR WITH MINIMAL OPEN REDUCTION AND A HYBRID SYSTEM. The study group was consisted of 16 males (76%) and 5 females (24%) with an average age for males of 43.06 years (range 25 to 65) and for females of 53.4 years (range 41 to 59). All the patients were in the age group of 26 to 65 years, mean age is 43.09. In the present s Result: tudy of 21 cases, the use of Hybrid external xation, as a denite treatment, for high – energy proximal tibia bicondylar fractures proved to be benecial.