Готові списки джерел за темами / TTF triple

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Добірка наукової літератури з теми "TTF triple"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "TTF triple"

1

Dranitsaris, George, Debu Tripathy, Nancy L. Beegle, Traci L. Kalberer, John David Cox, and Claudio Faria. "Real-world analysis of eribulin in metastatic breast cancer (MBC): An assessment of time to treatment failure (TTF) in a community oncology setting." Journal of Clinical Oncology 31, no. 26_suppl (2013): 174. http://dx.doi.org/10.1200/jco.2013.31.26_suppl.174.

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174 Background: There have been important advances in the treatment of patients with MBC. However, certain patient subgroups such as whose who are triple negative remain a therapeutic challenge. Eribulin is the newest cytotoxic to gain regulatory approval for MBC in the Unites States. In this analysis, the safety and efficacy of eribulin in TNBC patients and those with prior anthracycline exposure were assessed in an early cohort treated in a U.S. community oncology setting. Methods: Ninety patients treated in eight community oncology clinics across the U.S. were identified. Patients were foll
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2

Dranitsaris, George, Stefan Glück, Claudio Faria, David Cox, and Hope S. Rugo. "A comparative effectiveness analysis of single-agent cytotoxics in triple-negative metastatic breast cancer patients." Journal of Clinical Oncology 32, no. 26_suppl (2014): 157. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.157.

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157 Background: There has been considerable progress in treatments for MBC. However, the identification of optimal cytotoxic agents in patients with triple negative disease (negative for hormone receptors, ER/PR and HER-2) remains a therapeutic challenge. A comparative effectiveness analysis of four cytotoxic agents was conducted in patients with TN MBC. Methods: We retrospectively identified 225 patients treated with single agent eribulin (E=47), capecitabine (C=69), gemcitabine (G=56) or vinorelbine (V=53) in 19 community oncology clinics across the US. Data collection included baseline pati
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3

Maher, Mohamed, Shady H. E. Abdel Abdel Aleem, Ahmed M. Ibrahim, and Adel El-Shahat. "Novel Mathematical Design of Triple-Tuned Filters for Harmonics Distortion Mitigation." Energies 16, no. 1 (2022): 39. http://dx.doi.org/10.3390/en16010039.

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The design of AC filters must meet the criteria of harmonic distortion mitigation and reactive power support in various operating modes. The stringent reactive power-sharing requirements currently lead to sophisticated filter schemes with high component ratings. In this regard, triple-tuned filters (TTFs) have good potential in harmonic mitigation of a broad range of harmonics. In the literature, the TTF design has been presented using a parametric method, assuming that the TTF is equivalent to a three-arm single-tuned filter (TASTF). However, no direct methods of designing it or finding its o
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4

Ahn, Sejung, Yukyung Kim, Seungjae Beak, et al. "Synthesis and electrical conductivity of perchlorate-doped TTF–diamide nanofibers with double and triple helix structures." Journal of Materials Chemistry 20, no. 48 (2010): 10817. http://dx.doi.org/10.1039/c0jm02628j.

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5

Schwingshackl, Andreas, Benjamin Lopez, Bin Teng, et al. "Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 6 (2017): L1030—L1046. http://dx.doi.org/10.1152/ajplung.00121.2017.

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We previously proposed a role for the two-pore domain potassium (K2P) channel TREK-1 in hyperoxia (HO)-induced lung injury. To determine whether redundancy among the three TREK isoforms (TREK-1, TREK-2, and TRAAK) could protect from HO-induced injury, we now examined the effect of deletion of all three TREK isoforms in a clinically relevant scenario of prolonged HO exposure and mechanical ventilation (MV). We exposed WT and TREK-1/TREK-2/TRAAK-deficient [triple knockout (KO)] mice to either room air, 72-h HO, MV [high and low tidal volume (TV)], or a combination of HO + MV and measured quasist
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6

Peng, Yan, Yasmeen M. Butt, Beiyun Chen, Xinmin Zhang, and Ping Tang. "Update on Immunohistochemical Analysis in Breast Lesions." Archives of Pathology & Laboratory Medicine 141, no. 8 (2017): 1033–51. http://dx.doi.org/10.5858/arpa.2016-0482-ra.

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Context.— The utility of immunohistochemistry (IHC) in breast lesions needs to be updated with exceptions among these lesions. Biomarker studies with IHC in triple-negative breast carcinoma may help develop targeted therapies for this aggressive breast cancer. The distinction of metastatic lung adenocarcinoma to the breast and invasive breast carcinoma has significant prognostic and therapeutic implications. The determination can be challenging because both primary tumors can express estrogen receptor and/or HER2 by IHC, creating a diagnostic dilemma. Objectives.— To provide a practical update
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El-Maqsoud, Nehad M. R. Abd, Ehab Rifat Tawfiek, Ayman Abdelmeged, Mohamed Fathy Abdel Rahman, and Alaa A. E. Moustafa. "The diagnostic utility of the triple markers Napsin A, TTF-1, and PAX8 in differentiating between primary and metastatic lung carcinomas." Tumor Biology 37, no. 3 (2015): 3123–34. http://dx.doi.org/10.1007/s13277-015-3964-3.

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8

Spiegel, Jay, Caroline Jane McNamara, Andrea Arruda, et al. "Impact of Genomic Alterations on Outcomes in Myelofibrosis Patients Undergoing JAK1/2 Inhibitor Therapy." Blood 128, no. 22 (2016): 4263. http://dx.doi.org/10.1182/blood.v128.22.4263.4263.

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Abstract Introduction: The advent of next generation sequencing (NGS) has brought intense interest to the complex genetic landscape of myeloproliferative neoplasms (MPN). However, data regarding clinical outcomes in the context of novel MPN therapies such as JAK inhibitors are scarce. Limited data indicate that high molecular risk signature (HMR, presence of at least one mutation in ASXL1, EZH2, IDH1/2, SRSF2) or multiple mutations may be associated with decreased spleen response and a shorter time to discontinuation of Ruxolitinib in myelofibrosis (Patel et al, Blood 2015). Methods: All myelo
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9

Eisen, Tim, Yaroslav Shparyk, Robert Jones, et al. "Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients." Journal of Clinical Oncology 31, no. 15_suppl (2013): 4506. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4506.

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4506 Background: Sunitinib (S) is established as a standard first-line therapy for patients (pts) with advanced RCC. However, treatment can be limited by the occurrence of drug-related adverse events (AEs). This Phase II study assessed the efficacy and safety of nintedanib (N) – a potent, triple angiokinase inhibitor of VEGFR-1–3, PDGFR-α/β, and FGFR-1–3, as well as RET and Flt3 – vs S in previously untreated pts with RCC. Methods: Ninety-nine eligible pts (96 of whom were treated) with advanced, unresectable/recurrent clear cell RCC, an ECOG performance status of 0–1, and no prior systemic th
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10

Sharma, Rajni, Grzegorz Gurda, Susan Geddes, Edward Gabrielson, Frederic Askin, and Qing Kay Li. "Validation of the Novel Triple Marker (Combination of TTF, Napsin-A and p40) in the Subclassification of Non-Small Cell Lung Carcinomas (NSCLC) Using Fine Needle Aspiration (FNA) Cytological Materials." Journal of the American Society of Cytopathology 3, no. 5 (2014): S83. http://dx.doi.org/10.1016/j.jasc.2014.09.195.

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Дисертації з теми "TTF triple"

1

Martini, Lorenzo. "Local coherence of hearts in the derived category of a commutative ring." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/354322.

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Анотація:
Approximation theory is a fundamental tool in order to study the representation theory of a ring R. Roughly speaking, it consists in determining suitable additive or abelian subcategories of the whole module category Mod-R with nice enough functorial properties. For example, torsion theory is a well suited incarnation of approximation theory. Of course, such an idea has been generalised to the additive setting itself, so that both Mod-R and other interesting categories related with R may be linked functorially. By the seminal work of Beilinson, Bernstein and Deligne (1982), the derived categor
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2

Paquet, Joseph. "Potentialités anti-inflammatoires de l'inhibition génomique et transcriptionnelle du TNF-[alpha] par une approche de type oligonucléotidique." Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10067/document.

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Le Tumor Necrosis Factor alpha (TNF-[alpha]) est une cytokine pro-inflammatoire qui occupe un rôle central dans la physiopathologie de nombreuses pathologies inflammatoires et particulièrement l'arthrite. La neutralisation de cette cytokine par l'utilisation d'anticorps anti-TNF-[alpha] a montré son efficacité dans la polyarthrite rhumatoïde et est aujourd'hui le traitement de référence pour la prise en charge de cette pathologie. Cependant, un tiers des patients traités par anticorps anti-TNF restent réfractaires ou ne répondent pas à ce traitement. Dans ce contexte, il apparait nécessaire de
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3

Alazemi, Abdulrahman. "Investigation of Factors in Triplet-Triplet Annihilation Upconversion." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521189118425574.

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4

Westbrook, Emily Grace. "Development and Investigation of Methods for Improving Triplet-Triplet Annihilation Upconversion." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1583154398097115.

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5

Kristoffersson, Fredrik. "Novel target genes of ZEB1 and Snail1 in triple-negative human breast cancer." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356578.

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Анотація:
Breast cancer is comprised of several subtypes that are different from one another and thedivergence leads to different outcomes of the disease. There are known prognostic factors andphenotypic distinction in different biological factors and expression patterns, such as theestrogen receptor (ER), progesterone receptor (PR), Ki67, HER2/neu expression (HER2). Ingeneral, there are three breast cancer subtypes with the most recurring subtype being luminalA, and the other two being luminal B and triple negative breast cancer. Triple negative breastcancer is a heterogeneous subtype which is defined
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6

Kim, Hyun-Min. "Genome instability induced by triplex forming mirror repeats in S.cerevisiae." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33874.

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The main goal of this research is to understand molecular mechanisms of GAA/TTC-associated genetic instability in a model eukaryotic organism, S. cerevisiae. We demonstrate that expanded GAA/TTC repeats represent a threat to eukaryotic genome integrity by triggering double-strand breaks and gross chromosomal rearrangements. The fragility potential strongly depends on the length of the tracts and orientation of the repeats relative to the replication origin and to block replication fork progression. MutSbeta complex and endonuclease activity of MutLalpha play an important role in facilitation o
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7

Barona, Marco Antonio Acevedo. "Epistasia e interação epistasia por locais para a produção de grãos em soja." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-20032008-173225/.

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Nos programas de melhoramentos de soja as progênies endogâmicas são frequentemente avaliadas como possíveis cultivares. O estudo da estrutura da variação genética entre progênies de diferentes gerações de autofecundação depende da ação dos locos envolvidos e da variação do caráter sob estudo. Em soja o caráter produção de grãos (PG) é considerado o de maior importância econômica e destaca-se por apresentar herança quantitativa e ser altamente influenciada pelo ambiente. As estratégias de seleção utilizadas para o desenvolvimento de cultivares em soja poderiam ser otimizadas através do estudo d
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8

Cherta, Cucala Laura. "Potencial de diferentes analizadores y fuentes de ionización en cromatografí­a de gases-espectrometría de masas en el campo de la seguridad alimentaria y medioambiental." Doctoral thesis, Universitat Jaume I, 2014. http://hdl.handle.net/10803/285680.

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En la presente Tesis Doctoral se han estudiado las posibilidades de la cromatografía de gases (GC) acoplada a espectrometría de masas (MS) con distintos analizadores y fuentes de ionización para la determinación de contaminantes en muestras alimentarias y medioambientales. La singularidad de los cuatro instrumentos diferentes empleados reside en los analizadores de masas que los componen: cuadrupolo simple (Q), tiempo de vuelo (TOF), triple cuadrupolo (QqQ) e híbrido cuadrupolo tiempo de vuelo (QTOF). En los dos primeros sistemas, el modo de ionización aplicado ha sido el más frecuentemente ut
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9

"Characterization of the optical properties of metalloporphyrins in TiO2 sol-gel films for photon upconversion applications." Thesis, 2013. http://hdl.handle.net/10388/ETD-2013-10-1028.

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The photophysical properties of a series of Zn (II) porphyrins adsorbed onto a semiconductor were investigated using steady-state absorbance and emission measurements. The ability of the porphyrins to undergo triplet-triplet annihilation (TTA), a photophysical process through which photons in the red and near-infrared (NIR) regions of the optical spectrum can be converted into higher energy photons (upconversion), was explored. Aggregation capabilities were determined to verify possibility of these molecules to undergo triplet-triplet annihilation (TTA). TTA has significant potential for incre
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Figueiredo, Sónia Filipa da Silva. "The importance of document management and the future of clinical trials archive." Master's thesis, 2018. http://hdl.handle.net/10316/84486.

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Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>O ensaio clínico é uma parte fundamental no desenvolvimento de um novo medicamento, fazendo a ponte entre a investigação científica e a clínica e, posteriormente, o mercado. A parte clínica de um ensaio tem uma duração restrita, cedendo o lugar aos documentos do arquivo, a fim de “contarem a história do ensaio”. São esses documentos que suportam o pedido de submissão às autoridades para introdução no mercado do produto teste; e estão disponíveis no momento de uma inspecção por parte das
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Книги з теми "TTF triple"

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Boyd, Tristan, and Arthur Kavanaugh. Biologic DMARDs (TNF inhibitors). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0029.

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Tumor necrosis factor-α‎ inhibitors (TNFi) can effectively treat all domains of disease in patients with psoriatic arthritis (PsA). They have been shown to be effective and also generally safe and well tolerated in numerous clinical trials. This chapter reviews clinical trial evidence for the efficacy and safety of TNFi in PsA and highlights evidence-based treatment recommendations for their use. Emerging treatment strategies involving the use of TNFi in the management of PsA are also discussed.
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2

Rivera-Lara, Lucia, and Romergryko G. Geocadin. Neurobiology of Brain Injury after Cardiac Arrest. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0189.

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The publication of two sentinel, multicenter, randomized controlled trials in The New England Journal of Medicine in 2002 provided evidence for the beneficial use of therapeutic hypothermia (TTH) to 32° to 34°C in resuscitated patients after cardiac arrest with a shockable rhythm. The number needed to treat to provide a favorable neurological outcome was 6, and TTH is a recommended treatment in the American Heart Association (AHA) Resuscitation Guidelines. This chapter describes the biological basis of disorders of arousal and awareness after cardiac arrest, the mechanisms of ischemic cell dea
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3

Ray, Sumantra (Shumone), Sue Fitzpatrick, Rajna Golubic, Susan Fisher, and Sarah Gibbings, eds. Essential documents. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199608478.003.0022.

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Анотація:
It is a legal requirement for sponsors and investigators to maintain essential documentation. This chapter outlines the ICH GCP E6 requirements for documentation before, during and after the study. It describes each document and its purpose in the study. The chapter also describes how to deal with additional documentation kept by sponsors and sites but not addressed in the guidelines e.g. correspondence, emails and notes to file, The organisation of the trial master file (TMF) is not defined in guidelines but many companies and institutions will have a filing system described in SOPs, most are
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4

Cañete, Juan D., and Julio Ramírez. Enthesitis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0011.

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Enthesitis is common in psoriatic arthritis (PsA) occurring in50–60% of patients in clinical trials. Outcome measures for enthesitis have been developed, but its clinical diagnosis may be challenging at sites other than the Achilles and plantar insertions. Power Doppler ultrasound is more sensitive than clinical examination in detecting inflammatory and/or structural changes in asymptomatic patients, which have an unknown significance. Magnetic resonance imaging is useful to evaluate enthesitis and the best technique for osteitis. The concept of synovial–entheseal complex highlights the functi
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5

Sternbach, Marion. Apheresis in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0268.

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This chapter describes therapeutic plasma exchange, as well as cytapheresis for hyperleukocytosis and essential thrombocythemia, as well as harvesting haematological stem cells (HSC) for transplantation. Instrumentation and techniques are mostly density centrifugation, much less column adsorption for antibodies or membrane filtration for noxious molecules. Pathophysiology of apheresis is dealt with in great detail with emphasis on prevention and treatment of side effects, much more critical in the intensive care unit (ICU) setting. Main manifestations are: hypocalcaemia due to chelation by ant
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Fleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.

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Анотація:
Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and SyK pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Tofacitinib is an orally administered small-molecule inhibitor that targets the intracellular Janus kinase 3 and 1 (JAK1/3) molecules to a greater extent than JAK2 while baricitinib (formerly INCB028050) predominantly inhibits JAK1/2. Many of the proinflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK-STAT signalling
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Частини книг з теми "TTF triple"

1

Hamel, J. "Planovalguskorrektur durch tarsale Triple-Osteotomie (TTO)." In Sprunggelenk und Rückfuß. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-45571-5_17.

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2

Vermorken, Jan B. "Where and when to Use Induction Chemotherapy in Head and Neck Squamous Cell Cancer." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_11.

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AbstractThe treatment of locoregionally advanced squamous cell carcinoma of the head and neck (LA-HNSCC) is reviewed, highlighting the milestones in systemic therapy in that setting, with focus on the role of induction chemotherapy (ICT). The road to what is now considered the standard ICT regimen, i.e. the TPF (docetaxel/cisplatin/5-FU) regimen is described, and the differences between the European and the American TPF are discussed. The article describes the respective roles of ICT for larynx preservation, for treatment intensification, its role in patients with borderline resectable or unresectable oral cavity cancer, its role as a selection tool for radiotherapy dose de-escalation in patients with oropharyngeal squamous cell cancer (OPSCC) and its potential future role in strategies aiming at synchronous oligometastatic disease.ICT has an established role for organ preservation in advanced laryngeal and hypopharyngeal cancer and the TPF regimen has been validated in that setting. This approach is presently being compared in a randomized controlled trial to concurrent chemoradiotherapy (CCRT), which in many parts of the world is considered the standard organ preservation procedure. There remains uncertainty about the benefit of the sequential approach of ICT followed by CCRT, despite the fact that ICT significantly reduces the occurrence of distant metastases. It is advised that future studies should include patients who have the highest risk to develop distant metastases, in particular patients with low neck nodes and matted nodes. Moreover, further studies in patients with HPV-associated OPSCC at risk for distant failure (T4 or N3 disease) should be considered for that also. These approaches still need to be confirmed in adequately sized randomized controlled trials. Outside clinical trials, the utility of ICT is restricted to uniquely pragmatic clinical scenarios, such as unavoidable delay in radiation or in the situation that RT is not tolerated or feasible. This can happen when there is severe pain from advanced disease or there is impending airway compromise or neurologic dysfunction that necessitates rapid initiation of treatment. In all those circumstances whether within the context of trials or outside trials, it is imperative that the present backbone of ICT, the TPF regimen, is being administered by experienced oncologists, familiar with the necessary protocols and supportive care requirements to ensure patient safety and maximize adherence throughout the treatment.Future areas of research are the role of ICT in strategies whereby ICT is combined with upfront metastases-directed treatments and the usefulness of targeted agents or immune checkpoint inhibitors in the induction setting. Studies in that direction have already started. Finally, the application of radiographic, proteomic and genomic biomarkers will get attention to further define prognostic groups and guide treatment selection with greater precision.
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D’Anna, C., D. Bibbo, M. Goffredo, M. Schmid, and S. Conforto. "Efficacy of TtB-Based Visual Biofeedback in Upright Stance Trials." In IFMBE Proceedings. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-00846-2_433.

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4

Niu, Xiaoshuang, and Yungan Tao. "New Developments in the Management of Nasopharyngeal Carcinoma." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_22.

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AbstractNasopharyngeal carcinomas (NPC) have unique characteristics with a specific geographic distribution and radiotherapy (RT) is the cornerstone of initial treatment due to its radiosensitive behaviour and deep-seated location. Intensity modulated radiotherapy (IMRT) has become the standard RT technique compared with 2D/3D and could reduce the late toxicities such as xerostomia. We established the international guideline for the delineation of clinical target volumes (CTV) and dose prioritization and constraint guideline for a better implementation of IMRT for NPC. The role of RT in addition to systemic therapy for the initially diagnosed metastatic NPC has recently been investigated in a randomized trial. The meta-analysis MAC-NPC confirmed the role of chemotherapy in addition to RT for NPC and established concomitant chemoradiotherapy (CCRT) as a standard of care in locally advanced (LA) NPC. In the recent actualization of MAC-NPC and network meta-analysis, more chemotherapy (adjuvant or induction) has been suggested to further improve treatment efficacy. However, a randomized trial did not shown survival benefit of adjuvant chemotherapy in addition to CCRT in LA-NPC. More recently, several phase III trials (French GORTEC trial and Chinese trials) showed benefit of induction chemotherapy (PF/TPF/GP) when added to cisplatin-based chemoradiotherapy. Preliminary study has failed to show benefit of adjuvant chemotherapy for the patients with detectable plasma Epstein Barr virus (EBV) DNA after chemoradiotherapy. The presentation will also focus on the ongoing trials with association of immune checkpoint inhibitors with chemoradiotherapy and the role of EBV DNA during or after treatment among others.
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Bentz, B. L., and R. E. Honig. "Design of an Organic SIMS Instrument with Separate Triple Stage Quadrupole (TSQ) and Time-of-Flight (TOF) Spectrometers." In Springer Proceedings in Physics. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82718-1_36.

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Deng, Shuang, David Scott, and Uttam Garg. "Quantification of Five Clinically Important Amino Acids by HPLC-Triple TOF™ 5600 Based on Pre-column Double Derivatization Method." In Clinical Applications of Mass Spectrometry in Biomolecular Analysis. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3182-8_6.

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Sande, Beverly, and Camille S. Burnett. "The Triage Implementation Framework." In Collaborative Models and Frameworks for Inclusive Educator Preparation Programs. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3443-7.ch002.

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There are several models and frameworks used for continuous improvement in many education preparation programs (EPPs). Each program selects a framework or model that would best meet their improvement needs. In this chapter, the authors propose a novel framework that EPPs can use to prioritize continuous improvement activities. This model serves as a pre-implementation framework that can assist a team in determining how to select a critical area of implementation with the greatest impact. The novel framework is the triage implementation framework (TIF). The authors will describe a case study that used TIF, what it means to triage, and how the TIF can benefit EPPs.
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8

Templin, Christian. "Introduction." In ESC CardioMed. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0313.

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Takotsubo syndrome (TTS) has been recognized for over 25 years; however, its pathophysiology is still unclear. Although this disease is increasingly recognized, the true prevalence of TTS is still underestimated and the disease course underappreciated. Extensive research over the last years has contributed to a better understanding of TTS. As such, TTS is no longer only the disease of postmenopausal women with an emotional stressor, apical ballooning, and benign prognosis. TTS has a much more diverse clinical picture and can result in acute life-threating complications. Therapeutic management of TTS is still challenging and evidence-based treatment entirely lacking. Therefore, prospective trials are needed to assess different treatment options in order to improve the outcome of TTS patients.
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9

Rosales, Jesus. "Drive large TFT-LCD displays with a space-saving triple-output regulator." In Analog Circuit Design. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-800001-4.00291-x.

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10

Ahmed, Nazmin. "Management of High-Grade Meningioma: Present, Past and Promising Future." In Central Nervous System Tumors [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108414.

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High-grade meningiomas have a persistent therapeutic challenge, which the World Health Organization (WHO) categorizes as grade II and III lesions, represent 10–20% and 5% of individuals with meningiomas, respectively. Although grade I meningiomas can be completely surgically removed and have long-term progression-free survival, higher grade meningiomas are more likely to return aggressively and to be resistant to conventional treatments. Recently, stereotactic radiosurgery (SRS) has offered promise for the treatment of localized tumors. The era of molecular targeted treatment is now upon us. Patients are being enrolled in clinical trials with a variety of innovative medications that target driver mutations, and these trials might result in more effective treatment plans. Alpha-interferon, vascular endothelial growth factor inhibitors, and somatostatin receptor agonists are among the medications that are advised for the medical treatment of meningiomas in addition to radiation and surgical excision. For the treatment of meningioma, efforts to find novel informative mutations and protein biomarkers have advanced. Several patient populations have shown promise for improved outcomes with EZH2 inhibition. Overall, it is hoped that targeted research and the application of those strategies, such as PRRT and TTF devices, would lead to better results in future. This chapter aims to discuss the neuroimaging features of high grade meningiomas, diagnostic and therapeutic implications of recently discovered genetic alterations and outcome. There will be a brief review focusing on ongoing clinical trials of novel therapeutic agents and future research scope in this arena.
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Тези доповідей конференцій з теми "TTF triple"

1

Wu, Jinyuan, M. Wang, E. Gottschalk, and Z. Shi. "Curved Track Segment Finding Using Tiny Triplet Finder (TTF)." In 2006 IEEE Nuclear Science Symposium Conference Record. IEEE, 2006. http://dx.doi.org/10.1109/nssmic.2006.356077.

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Jinyuan Wu, M. Wang, E. Gottschalk, and Z. Shi. "The application of tiny triplet finder (TTF) in BTeV pixel trigger." In 14th IEEE-NPSS Real Time Conference, 2005. IEEE, 2005. http://dx.doi.org/10.1109/rtc.2005.1547448.

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Lee, Jongchan, Jaehyun Moon, Jae-Eun Pi, et al. "Transparent triple-layer oxide TFT for enhanced photo switching characteristics." In 2018 25th International Workshop on Active-Matrix Flatpanel Displays and Devices (AM-FPD). IEEE, 2018. http://dx.doi.org/10.23919/am-fpd.2018.8437364.

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4

Chandler, Benjamin C., Leah Moubadder, Cassie Ritter, et al. "Abstract 677: TTK: A novel target for radiosensitization in triple-negative breast cancers." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-677.

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5

Ghosh, Angshuman, Karan Deshmukh, and Gracious Ngaile. "Database for Real-Time Loading Path Prediction for Tube Hydroforming Using Multidimensional Cubic Spline Interpolation." In ASME 2010 International Manufacturing Science and Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/msec2010-34099.

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Анотація:
Tube Hydroforming (THF) is a metal-forming process that uses a pressurized fluid in place of a hard tool to plastically deform a given tube into a desired shape. In addition to the internal pressure, the tube material is fed axially toward the die cavity. This process has various applications in the automotive, aerospace, and bicycle industries. Accurate coordination of the fluid pressure and axial feed, collectively referred to as a loading path, is critical to THF. Workable loading paths are currently determined by trial and error, which can be time consuming. This paper discusses an innovat
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Saboori, M., J. Gholipour, H. Champliaud, A. Gakwaya, J. Savoie, and P. Wanjara. "Prediction of Burst Pressure in Multi Stage Tube Hydroforming of Aerospace Alloys." In ASME Turbo Expo 2015: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/gt2015-43893.

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Bursting, an irreversible failure in tube hydroforming (THF), results mainly from the local plastic instabilities that occur when the biaxial stresses imparted during the process exceed the forming limit strains of the material. To predict the burst pressure, Oyane’s and Brozzo’s decoupled ductile fracture criteria were implemented as user material models in a dynamic nonlinear commercial 3D finite element (FE) software, Ls-Dyna. THF of a round to V-shape was selected as a generic representative of an aerospace component for the FE simulations and experimental trials. To validate the simulatio
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Lee, Jeongmin. "Abstract 1041: TGF-β1-induced EMT is suppressed by berberine in triple negative breast cancers". У Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1041.

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Wang, Ling, Zhimin Hou, Emily Gronseth, Janet Rader, David Harder та Ramani Ramchandran. "Abstract LB-215: Astrocytes promote brain metastasis of triple-negative great cancer through TGF-β2/ANGPTL4 axis". У Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-215.

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Ji, H., Z. Wang, C. Mo та M. Zhang. "Abstract P2-12-02: discovery of the β-catenin/Tcf inhibitors for treatment of triple negative breast cancer". У Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-12-02.

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Calvo, Veronica, Orsi Giricz, and Paraic A. Kenny. "Abstract A54: TACE-regulated TGF-alpha shedding drives GRB7-dependent invasion in triple-negative breast cancer cell lines." In Abstracts: AACR Special Conference on Tumor Invasion and Metastasis - January 20-23, 2013; San Diego, CA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tim2013-a54.

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Звіти організацій з теми "TTF triple"

1

Zhao, Binghao, Yu Wang, and Wenbin Ma. Comparative Efficacy and Safety of Therapeutics for Elderly Glioblastoma: a Bayesian Network Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.3.0094.

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Review question / Objective: At this time, a comprehensive systematic review and network meta-analysis (NMA) was conducted to: (1) fill the research gap by giving rankings on treatment efficacy; (2) provide statistical evidence of not head-to-head comparisons; (3) seek out the best and up-to-date therapeutic strategy reported in latest RCTs; (4) address potential adverse events (AEs) of available treatments. Condition being studied: The incidence of glioblastoma (GBM) increases with age, until now, there has been less evidence on the optimal treatments for elderly GBM since only general GBM po
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2

Tian, Cong, Jianlong Shu, Wenhui Shao, Zhengxin Zhou, Huayang Guo та Jingang Wang. The efficacy and safety of IL Inhibitors, TNF-α Inhibitors, and JAK Inhibitor on ankylosing spondylitis: A Bayesian network meta-analysis of a “randomized, double-blind, placebo-controlled” trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.9.0117.

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Анотація:
Review question / Objective: In this study, we conducted a Bayesian network meta-analysis to evaluate the efficacy and safety of interleukin (IL) inhibitors, tumor necrosis factor-alpha (TNF-α) inhibitors, and Janus kinase (JAK) inhibitors on ankylosing spondylitis (AS).The purpose of this study is to compare the effectiveness and safety of different interventions for treating AS to provide insights into the decision-making in clinicalpractice. Condition being studied: Ankylosing spondylitis. Based on the Bayesian hierarchical model, we conducted a network meta-analysis using the gemtc package
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Blanken, Annelies, Bafrin Abdulmajid, Eva van Geel, Joost Daams, Martin van der Esch, and Michael Nurmohamed. Effect of tumor necrosis factor inhibiting treatment on arterial stiffness and arterial wall thickness in rheumatoid arthritis patients: protocol for a systematic review and planned meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.1.0131.

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Review question / Objective: The aim of this systematic review is to evaluate the effect of TNF inhibiting treatment on arterial stiffness (as measured with pulse wave velocity and augmentation index) and arterial wall thickness (as measured with carotid intima media thickness) in rheumatoid arthritis patients. Condition being studied: Rheumatoid arthritis is a chronic autoimmune disorder, which affects approximately 1% of the population worldwide. Information sources: The following electronic databases will be searched for potentially eligible studies: EMBASE, MEDLINE, ClinicalTrials.gov and
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