Дисертації з теми "TRNA Function"
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Boonyalai, Nonlawat. "Lysyl-tRNA synthetase : structure-function studies." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429379.
Повний текст джерелаKelly, Paul Michael. "Characterizing the Function of Alanyl-tRNA Synthetase Activity in Microbial Translation." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586259003806337.
Повний текст джерелаDhungel, Nripesh. "tRNA Splicing Endonuclease: Novel and Essential Function Beyond tRNA Splicing and Subunit interactions." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337968400.
Повний текст джерелаSwinehart, William E. Jr. "A Biochemical Investigation of Saccharomyces cerevisiae Trm10 and Implications of 1-methylguanosine for tRNA Structure and Function." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429867956.
Повний текст джерелаRogers, Theresa Elizabeth. "Elucidating the Function of a Pseudo-tRNA in Bacillus cereus." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291213318.
Повний текст джерелаFaruggio, Dawn C. (Dawn Catherine) 1965. "Stucture-function relationships of human initiator tRNA mutants and attempted regulated expresion of tRNA genes in yeast." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/32665.
Повний текст джерелаPicchioni, Daria. "Biological function of SLIMP, a mitochondrial seryl-tRNA synthetase paralog." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/283974.
Повний текст джерелаEl nostre grup de recerca es centra en la traducció de proteïnes i més específicament en el mecanisme d’aminoacilació dels àcids ribonucleics (ARNs) de transferència (ARNt) per una família d’enzims essencials i universals anomenats aminoacil-ARNt sintetases (aaRSs). Al laboratori s’han analitzat el paper de les aaRSs en la traducció proteica, les seves funcions no canòniques, la seva evolució, així com la seva implicació en malalties humanes. Les aaRSs són components universals i essencials del codi genètic. La seva llarga historia evolutiva explica el creixent número de funcions que s’estan descobrint, tant per a elles com per a proteïnes paràlogues, més enllà del seu paper canònic en traducció genètica. Al laboratori, durant el procés d’obtenció d’un model a Drosophila melanogaster per a l’estudi de malalties humanes degudes a deficiències en l’aminoacilació d’ARNt, es va identificar un nou gen, paràlog de la seril-ARNt sintetasa (SeRS) mitocondrial, anomenat SLIMP. La proteïna SLIMP representa un nou tipus de proteïna similar a aaRS que ha adquirit una funció essencial a insectes, tot i la relativament baixa divergència respecta a una estructura d’SeRS canònica. Tot i amb això, són necessaris estudis addicionals per a identificar el paper biològic de SLIMP. Per aconseguir aquesta fita, s’ha portat a terme el projecte descrit en aquest manuscrit, el qual consisteix en anàlisis addicionals del fenotip resultant de la depleció de SLIMP in vivo, seguits d’estudis detallats de les interaccions moleculars amb àcids nucleics i proteïnes, per acabar amb un estudi dels efectes de SLIMP en la fisiologia cel•lular. En conjunt, els nostres resultats demostren que SLIMP s’uneix específicament a ARNs mitocondrials in vivo i in vitro. SLIMP interacciona amb SerRS2 i les dues són interdependents a nivell d’estabilitat proteica. La depleció de SLIMP o de SerRS2 redueix els nivells basals d’alguns ARNm mitocondrials, però la transcripció d’ARNt és manté inalterada. Es proposa un rol en la regulació post-transcripcional o en l’estabilitat dels ARNm madurs. Hem observat també que la depleció de SLIMP indueix l’aturada del cicle cel•lular en la transició G2/M. Aquests resultats suggereixen que SLIMP, o una conseqüència de la seva funció, podria tenir un paper d’enllaç entre els mitocondris i els factors de transcripció nuclears que regulen la proliferació cel•lular.
Cacan, Ercan. "Evolutionary synthetic biology: structure/function relationships within the protein translation system." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45838.
Повний текст джерелаMirando, Adam Christopher. "Characterization Of A Non-Canonical Function For Threonyl-Trna Synthetase In Angiogenesis." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/523.
Повний текст джерелаKubicek, Charles E. 1981. "Identifying targets and function of the ubiquitin related modifier Urm1 in Saccharomyces cerevisiae." Thesis, University of Oregon, 2009. http://hdl.handle.net/1794/10310.
Повний текст джерелаPost-translational modification of proteins is an important cellular method of controlling various aspects of protein activity, including protein-protein interactions, half- life, and transport. An important class of post-translational modifications involves the ubiquitin family of proteins. In these modifications, a small protein, such as ubiquitin, is conjugated to a target protein through an isopeptide bond. Conjugation by a ubiquitin family member acts as a signal to regulate the activity, function, or stability of the target protein. Urm1, a ubiquitin-like protein conserved throughout all eukaryotes, was initially identified in S. cerevisiae. Loss of Urm1 leads to the disruption of a variety of cellular processes, including oxidative stress response, filamentous growth, and temperature sensitivity. This body of work comprises efforts to identify novel targets of Urm1, the mechanism by which Urm1 is attached to target proteins, and the physiological consequences of such conjugation. To gain understanding of the function and mechanism of Urm1 conjugation, the only known conjugate of Urm1, the peroxiredoxin reductase Ahp1, was examined in an effort to identify the site of modification on Ahp1 and to evaluate the physiological consequences of urmylation of Ahp1. I then completed a series of screens--a synthetic lethal screen, a two-hybrid screen, and a protein over-expression screen--to identify novel Urm1 conjugates and cellular functions dependent on Urm1. Of particular interest were genes identified in the synthetic lethal screen, namely PTC1, which encodes a protein phosphatase, and a set of genes encoding the Elongator complex, which functions in transcriptional elongation and tRNA modification. During this time period, other groups showed that thiolation of tRNAs depends on Urm1. Thus, Urm1 does not function only in protein conjugation, but also as a sulfur carrier in the thiolation of tRNA. Interestingly, I identified Elp2, a component of the Elongator complex, as a new Urm1-conjugate. Because Elp2 is also required for tRNA modification, perhaps Urm1 plays more than one role in tRNA modification. Loss of tRNA modification may disrupt many cellular functions and could explain the variety of urm1 mutant phenotypes. I have determined that all known Urm1 dependent processes are also associated with tRNA modification.
Committee in charge: Karen Guillemin, Chairperson, Biology; George Sprague, Advisor, Biology; Alice Barkan, Member, Biology; Kenneth Prehoda, Member, Chemistry; Tom Stevens, Outside Member, Chemistry
Wo, Peibin. "Assessment Of A Function For Threonyl-Trna Synthetase In Angiogenesis In A Mouse Ovarian Cancer Model." ScholarWorks @ UVM, 2017. https://scholarworks.uvm.edu/graddis/839.
Повний текст джерелаLongstaff, David Gordon. "Requirements and rationale for amber translation as pyrrolysine." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1196107921.
Повний текст джерелаChen, Peng. "Function of wobble nucleoside modifications in tRNAs of Salmonella enterica Serovar Typhimurium." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-328.
Повний текст джерелаHoward, C. Bradley Howard. "Development of gain-of-function reporters to probe trans-editing of misacylated tRNA in vivo." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469118488.
Повний текст джерелаSomme, Jonathan. "Structure-function relationship studies on the tRNA methyltransferases TrmJ and Trm10 belonging to the SPOUT superfamily." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209122.
Повний текст джерелаIn the first part of this work we have identified the TrmJ enzyme of Sulfolobus acidocaldarius (the model organism of hyperthermophilic Crenarchaeota) which 2’-O-methylates the nucleoside at position 32 of tRNAs. This protein belongs to the SPOUT superfamily and is homologous to TrmJ of the bacterium Escherichia coli. A comparative study shows that the two enzymes have different specificities for the nature of the nucleoside at position 32 as well as for their tRNA substrates. To try to understand these shifts of specificity at a molecular level we solved the crystal structure of the SPOUT domains of the two TrmJ proteins.
In the second part of this work, we have determined the crystal structure of the Trm10 protein of S. acidocaldarius. This is the first structure of a 1-methyladenosine (m1A) specific Trm10 and also the first structure of a full length Trm10 protein. The Trm10 protein of S. acidocaldarius is distantly related to its yeast homologues which are 1-methylguanosine (m1G) specific. To understand the difference of activity between the Trm10 enzymes, we compared the yeast and the S. acidocaldarius Trm10 structures. Remarkably several Trm10 proteins (such as Trm10 of Thermococcus kodakaraensis) are even able to form both m1A and m1G. To understand the capacity of the T. kodakaraensis protein to methylate A and G, a mutational study was initiated./Lors de la traduction, les ARN de transfert (ARNt) jouent le rôle crucial d’adaptateurs entre l’ARN messager et les acides aminés. Les ARNt sont transcrits sous forme de pré-ARNt qui doivent être maturés. Lors de cette maturation, plusieurs nucléosides sont modifiés. Un grand nombre de ces modifications sont des méthylations des bases ou du ribose. Quatre familles d’ARNt méthyltransferases sont actuellement connues, dont la superfamille des SPOUT. Les membres de cette superfamille sont caractérisés par un nœud dans la chaîne polypeptidique du côté C-terminal. C’est au niveau de ce nœud que se lie la S-adénosylméthionine qui est le donneur de groupement méthyle. A l’exception de Trm10 qui est monomérique, toutes les protéines SPOUT connues sont dimériques et leur site actif est formé de résidus provenant des deux protomères. Selon l’espèce, une même modification peut être formée à la même position dans la molécule d’ARNt par des enzymes qui appartiennent à des familles différentes. A l’opposé, des enzymes homologues peuvent présenter des spécificités ou des activités différentes.
Au cours de ce travail, nous avons identifié l’enzyme TrmJ de Sulfolobus acidocaldarius (l’organisme modèle des Crénarchées hyperthermophiles) qui méthyle le ribose du nucléoside en position 32 des ARNt. Cette protéine est un homologue de l’enzyme TrmJ de la bactérie Escherichia coli. L’étude comparative que nous avons réalisée a révélé que ces deux enzymes présentent une différence de spécificité pour la nature du nucléoside en position 32 ainsi que pour les ARNt substrats. Afin de comprendre ces différences de spécificité au niveau moléculaire, les structures des domaines SPOUT des deux TrmJ ont été déterminées et comparées.
En parallèle, nous avons résolu la structure cristalline de la protéine Trm10 de S. acidocaldarius. C’est la première structure disponible d’un enzyme Trm10 formant de la 1-méthyladénosine (m1A). C’est aussi la première structure complète d’une protéine Trm10. Les enzymes homologues des levures Saccharomyces cerevisiae et Schizosaccharomyces pombe qui n’ont que peu d’identité de séquence avec l’enzyme de S. acidocaldarius, forment de la 1-méthylguanosine (m1G). Dans le but de comprendre comment ces enzymes homologues peuvent présenter des activités différentes, leurs structures ont été comparées. De manière surprenante, certains homologues de Trm10 (comme l’enzyme de l’Euryarchée Thermococcus kodakaraensis) sont capables de former du m1A et du m1G. Afin de mieux comprendre comment ces protéines sont capables de méthyler deux types de bases, nous avons initié l’étude de l’enzyme Trm10 de T. kodakaraensis par mutagenèse dirigée.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Wallweber, Gerald J. "Characterization of Neurospora mitochondrial group I introns and the function of tyrosyl-tRNA synthetase in RNA splicing /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942739806006.
Повний текст джерелаFill, Mary-Margaret Anne. "Establishment of a tRNA over-expression system in Trypanosoma brucei to study the role of post-transcriptional modifications on function." Connect to resource, 2007. http://hdl.handle.net/1811/28390.
Повний текст джерелаTitle from first page of PDF file. Document formatted into pages: contains x, 25 p.; also includes graphics. Includes bibliographical references (p. 24-25). Available online via Ohio State University's Knowledge Bank.
Sanford, Brianne. "Role of Coupled Dynamics and a Strictly Conserved Lysine Residue in the Function of Bacterial Prolyl-tRNA Synthetase and Substrate Binding by a Related trans-Editing Enzyme ProXp-ala." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397645941.
Повний текст джерелаTyagi, Kshitiz. "A systems biology approach unravels the biological function of two tRNA wobble base modifications in fine-tuning translation and the response to environmental stress." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/32e734c5-198d-4c8a-9f56-7d5d19d1ef3d.
Повний текст джерелаMuchenditsi, Abigael M. "Effects of Metal Ions and Loop Stability on the Structure and Function of the T Box Antiterminator RNA and its complex with Model tRNA." Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1251219465.
Повний текст джерелаPrévost, Gilles. "Essais de clonage du gene de l'arginyl-arnt synthetase de saccharomyces cerevisiae : determination des domaines fonctionnels de l'aspartyl-arnt synthetase de saccharomyces cerevisiae." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13015.
Повний текст джерелаWiencek, Patrick. "Secondary Functions And Novel Inhibitors Of Aminoacyl-Trna Synthetases." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/941.
Повний текст джерелаKarim, Loukmane. "Organisation sous-mitochondriale de l'aspartyl-ARNt synthétase humaine et implication dans le syndrome LBSL." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ073/document.
Повний текст джерелаThe aim of the PhD project was to contribute to the understanding of the link between mutations in the human mitochondrial aspartyl-tRNA synthetase (mt-AspRS) and LBSL disease, by studying the properties of this enzyme at the cellular level. Our objectives were: 1) to explore the organization of mt-AspRS in mitochondria (Chapter 1), 2) to identify the mature form of mt-AspRS after its import, and to characterize its submitochondrial localization (Chapter 2), 3) to assess, in cellulo, the impact of some LBSL-causing mutations on some properties of mt-AspRS (Chapter 3). We showed that mt-AspRS is processed into different mature forms, and that mt-AspRS belongs to two complexes likely suggesting different partners and/or functions. We demonstrated that mt-AspRS is dually localized with soluble and peripherally membrane-associated fractions. We also demonstrated that, under stress conditions, mt-AspRS is released outside mitochondria with a possible link to the apoptosis. Furthermore, we assessed the impact of some LBSL-causing mutation on some cellular properties of mt-AspRS, and showed that most mutations do not have a significant impact. This underscores the need for more studies about mt-AspRS properties, and strongly suggests a potential non-canonical (alternative) function of the enzyme
Xu, Hao. "Functional aspects of modified nucleosides in tRNA." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109491.
Повний текст джерелаLong, Yicheng. "Characterization of the diverse functions of a family of 3'-5' reverse polymerases." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437563497.
Повний текст джерелаMechulam, Yves. "Controles de l'expression de l'operon phest-hima d'escherichia coli : attenuation et repression transcriptionnelle par hima et le systeme sos." Paris 7, 1987. http://www.theses.fr/1987PA077134.
Повний текст джерелаTran, Thi thanh tam. "Comparative and functional genome analysis of Acidithiobacillus bacteria." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4060.
Повний текст джерелаThe acidophilic Acidithiobacillus bacteria play an important role in industrial biomining operations for metal recovery. In this thesis, the genome sequence of a psychrotolerant Acidithiobacillus ferrivorans CF27 were first refined. The comparative genome analysis between CF27 and the closely related Acidithiobacillus genomes revealed: (i) a syntenic conservation of two tRNA array units which are only present in At. ferrivorans CF27 and At. ferrooxidans ATCC 23270 genomes and mainly contribute to the tRNA gene redundancy in both organisms. Moreover, our large-scale genome survey of the tRNA array units in prokaryotic organisms showed that tRNA arrays appear in few phyla; (ii) a high proportion of species-specific genes in CF27 and SS3 strains indicated the high variability of gene content in Acidithiobacillus genomes and therefore the unique nature of each group of species. Given that mRNA expression of some CF27 specific genes were confirmed in Fe(II)-grown cells and sulfur attached cells in CF27, these results highlighted the functional importance of specific genes for CF27 lifestyle; and (iii) the mosaic taxonomic composition of members of the Acidithiobacillia class, and thus confirmed that this group belongs to a particular taxonomic class, distinct to other proteobacterial groups. Taken together, our results provide insights into At. ferrivorans lifestyle as well as the chimeric genome nature of the Acidithiobacillus organisms. In addition, I also participated to the ‘Thioredoxin reductase’ project which aims to define the biochemical function, molecular structure and evolution of TRi, an atypical thioredoxin reductase
Esberg, Anders. "Functional aspects of wobble uridine modifications in yeast tRNA." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1093.
Повний текст джерелаDavis, Matthew W. (Matthew Warren) 1966. "Functional analysis of a class II aminoacyl-tRNA synthetase." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/26867.
Повний текст джерелаWu, Shiying. "Distal to Proximal—Functional Coupling in RNase P RNA-mediated Catalysis." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159312.
Повний текст джерелаSo, Byung Ran. "Characterization of the Cys-tRNAPro Editing Mechanism and Functional Interactions of Bacterial YbaK Protein." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1268257970.
Повний текст джерелаWalker, Sarah Elizabeth. "Functional Studies of Transfer RNA Interactions in the Ribosome." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1217605676.
Повний текст джерелаTakita, Teisuke. "The Structure and Functions of the Lysyl-tRNA Synthetase of Bacillus stearothermophilus." Kyoto University, 1996. http://hdl.handle.net/2433/78070.
Повний текст джерела0048
新制・課程博士
博士(農学)
甲第6479号
農博第892号
新制||農||720(附属図書館)
学位論文||H8||N2923(農学部図書室)
UT51-96-F358
京都大学大学院農学研究科食品工学専攻
(主査)教授 外村 辨一郎, 教授 左右 田健次, 教授 佐々木 隆造
学位規則第4条第1項該当
Wang, Tingzhang. "Make inferences about bacterial gene functions with the concept of neighborhood in silico." Thesis, Evry-Val d'Essonne, 2010. http://www.theses.fr/2010EVRY0036/document.
Повний текст джерелаWith more and more genomes being sequenced, the organization of those raw data and the derived data, the extraction of information and knowledge from these data has become a challenge. A key concept in this field is that of the neighborhood, especially with respect to the organization of data in relational databases. To extract information from bulk data, different kinds of neighborhoods were studied and each show interesting results in current study. .Firstly, through the Correspondence Analysis (CA) and later Model Based Clustering (MBC), two kinds of neighbors i.e. the genes (proteins) and amino acids were analyzed respectively, and it was found that proteins from Psychromonas ingrahamii are clustered into six classes, and there is strong opposition between asparagine (N) and the oxygen-sensitive amino acids. Secondly, the relationship between genomic islands and core genome (i.e. two closely linked neighbors withlarge range on the chromosome) was studied by a new method combining composition, GI features and synteny break. On applying to E. coli and B. subtilis it was revealed that this new method can extract some meaningful regions not published before. Thirdly, the relationship between upstream and coding regions of thrS gene (i.e. a case for two closely linked neighbors with small range on the chromosome) was studied extensively. It was found that these two regions associated to one gene, behaved differently in the evolutionary history.. Some of the upstream regions bearing non-essential function (i.e. regulation of gene expression) evolved more slowly than the coding region
Bou, Nader Charles. "Structural and Functional characterization of flavoenzymes involved in posttranscriptional modification of tRNA." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066205/document.
Повний текст джерелаPosttranscriptional modification of ribonucleic acids (RNAs) is a crucial maturation step conserved in all domains of life. During my thesis, I have brought structural and functional insights on flavoenzymes involved in transfer RNA (tRNA) modifications: dihydrouridine synthase (Dus) responsible for dihydrouridine formation using flavin mononucleotide (FMN) and TrmFO responsible for C5 methylation of uridine position 54 relying on flavin adenosine dinucleotide (FAD) and methylenetetrahydrofolate. To elucidate the chemical mechanism of TrmFO we designed an apoprotein via a single mutation that could be reconstituted in vitro with FAD. Furthermore, we chemically synthesized the postulated intermediate active species consisting of a flavin iminium harboring a methylene moiety on the isoalloxazine N5 that was further characterized by mass spectrometry and UV-visible spectroscopy. Reconstitution of TrmFO with this molecule restored in vitro activity on a tRNA transcript proving that TrmFO uses FAD as a methylating agent via a reductive methylation.Dus2 reduces U20 and is comprised of a canonical Dus domain however, mammals have an additional double-stranded RNA-binding domain (dsRBD). To bring functional insight for this modular organization, we showed that only full length human Dus2 was active while its isolated domains were not. tRNA recognition is driven by the dsRBD via binding the acceptor and TΨ stem of tRNA with higher affinity then dsRNA as evidenced by NMR. We further solved the X-ray structures for both domains showing redistribution of surface positive charges justifying the involvement of this dsRBD for tRNA recognition in mammalian Dus2. This was attributed to a peculiar N-terminal extension proven by mutational analysis and an X-ray structure of dsRBD in complex with 22-nucleotide dsRNA. Altogether our work illustrates how during evolution, Dus2 enzymes acquired an engineered dsRBD for efficient tRNA binding via a ruler mechanism
Rao, Bhalchandra Shantikumar. "Diverse Biological Functions For 3'-5' Nucleotide Addition Reactions: tRNA Repair to tRNAHis Identity." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397425994.
Повний текст джерелаGustavsson, Marie. "Studies of Intracellular Transport and Anticancer Drug Action by Functional Genomics in Yeast." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9408.
Повний текст джерелаFLORENTZ, EGELE CATHERINE. "L'extremite 3'oh aminoacyable du rna du virus de la mosaique jaune du navet : relations entre structure et fonctions." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13181.
Повний текст джерелаSimoneau, Steve. "Functional interactions between the p75 neurotrophin receptor and TrkA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0029/MQ64452.pdf.
Повний текст джерелаSimoneau, Steve. "Functional interactions between the p75 neurotrophin receptor and TrkA." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30747.
Повний текст джерелаChu, Hui-Yi. "Genome-wide Investigation of Cellular Functions for tRNA Nucleus-Cytoplasm Trafficking in the Yeast Saccharomyces cerevisiae." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343397048.
Повний текст джерелаHou, Zhiwei. "Fluorescence in blue light (FLU): Functional analysis of its structural domains for light and dark-dependent control of ALA synthesis." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/20951.
Повний текст джерелаFluorescence in blue light (FLU), a negative feedback regulator of chlorophyll biosynthesis, is involved in dark repression of 5-aminolevulinic acid (ALA) synthesis. FLU is part of a complex comprising the enzymes catalyzing the final steps of chlorophyll synthesis. Three functional domains were proposed in the Arabidopsis FLU protein: a tetratricopeptide repeat (TPR) domain is at the C-terminus; a transmembrane domain (TM) is at the N-terminus; a coiled-coil domain (linker) is in between. The TPR(FLU) domain interacts with the C-terminal end of glutamyl-tRNA reductase (GluTR), the rate-limiting enzyme of ALA synthesis. This thesis contributes to the extended knowledge about the function of FLU in light as well as the role of the structural domains of FLU in the inactivation of ALA synthesis.
Cho, I.-Ming. "Characterizing the Role of Ribosomal Protein L7Ae in Archaeal RNase P Catalysis and Exploring the Use of Archaeal RNase P as a Functional Genomics Tool." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1290555279.
Повний текст джерелаLUNGHI, GIULIA. "GM1 OLIGOSACCHARIDE MODULATION OF CALCIUM SIGNALLING IN NEURONAL FUNCTIONS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/792078.
Повний текст джерелаCherniack, Andrew David. "Involvement of mitochondrial tyrosyl tRNA synthetase in splicing : identification of an N-terminal domain that functions in splicing /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu148775817823818.
Повний текст джерелаMo, Fan. "Functional role of the conserved amino acids Cysteine 81, Arginine 279, Glycine 280 and Arginine 283 in elongation factor Tu from Escherichia coli." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, c2011, 2011. http://hdl.handle.net/10133/3107.
Повний текст джерелаx, 85 leaves : ill. (some col.) ; 29 cm
Mueller, Markus. "In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-43939.
Повний текст джерелаGurha, Priyatansh. "Functional characterization of archaeal pseudouridine synthases responsible for formation of conserved pseudouridines in tRNAs /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1650501181&sid=14&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерела"Department of Molecular Biology, Microbiology and Biochemistry." Includes bibliographical references (p. 101-120). Also available online.
Condon, Peter J. "Novel, Functional Interactions Between TrkA Kinase and p75 Neurotrophin Receptor in Neuroblastoma Cells: A Dissertation." eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/148.
Повний текст джерелаSun, Yishan. "Novel functions of drosophila TRPA channels pain and pyx in gravity sensing and the DEG/ENaC channel ppk11 in metabolic homeostasis." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/893.
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