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Статті в журналах з теми "TRNA Function"
Mangroo, Dev, Xin-Qi Wu, and Uttam L. Rajbhandary. "Escherichia coliinitiator tRNA: structure–function relationships and interactions with the translational machinery." Biochemistry and Cell Biology 73, no. 11-12 (December 1, 1995): 1023–31. http://dx.doi.org/10.1139/o95-109.
Повний текст джерелаSchaffer, Ashleigh E., Otis Pinkard, and Jeffery M. Coller. "tRNA Metabolism and Neurodevelopmental Disorders." Annual Review of Genomics and Human Genetics 20, no. 1 (August 31, 2019): 359–87. http://dx.doi.org/10.1146/annurev-genom-083118-015334.
Повний текст джерелаFrancis, M. A., and U. L. Rajbhandary. "Expression and function of a human initiator tRNA gene in the yeast Saccharomyces cerevisiae." Molecular and Cellular Biology 10, no. 9 (September 1990): 4486–94. http://dx.doi.org/10.1128/mcb.10.9.4486-4494.1990.
Повний текст джерелаFrancis, M. A., and U. L. Rajbhandary. "Expression and function of a human initiator tRNA gene in the yeast Saccharomyces cerevisiae." Molecular and Cellular Biology 10, no. 9 (September 1990): 4486–94. http://dx.doi.org/10.1128/mcb.10.9.4486.
Повний текст джерелаvon Pawel-Rammingen, U., S. Aström, and A. S. Byström. "Mutational analysis of conserved positions potentially important for initiator tRNA function in Saccharomyces cerevisiae." Molecular and Cellular Biology 12, no. 4 (April 1992): 1432–42. http://dx.doi.org/10.1128/mcb.12.4.1432-1442.1992.
Повний текст джерелаvon Pawel-Rammingen, U., S. Aström, and A. S. Byström. "Mutational analysis of conserved positions potentially important for initiator tRNA function in Saccharomyces cerevisiae." Molecular and Cellular Biology 12, no. 4 (April 1992): 1432–42. http://dx.doi.org/10.1128/mcb.12.4.1432.
Повний текст джерелаStrobel, M. C., and J. Abelson. "Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo." Molecular and Cellular Biology 6, no. 7 (July 1986): 2663–73. http://dx.doi.org/10.1128/mcb.6.7.2663-2673.1986.
Повний текст джерелаStrobel, M. C., and J. Abelson. "Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo." Molecular and Cellular Biology 6, no. 7 (July 1986): 2663–73. http://dx.doi.org/10.1128/mcb.6.7.2663.
Повний текст джерелаOberbauer, Vera, and Matthias Schaefer. "tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development." Genes 9, no. 12 (December 5, 2018): 607. http://dx.doi.org/10.3390/genes9120607.
Повний текст джерелаTucker, Jessica M., Aaron M. Schaller, Ian Willis, and Britt A. Glaunsinger. "Alteration of the Premature tRNA Landscape by Gammaherpesvirus Infection." mBio 11, no. 6 (December 15, 2020): e02664-20. http://dx.doi.org/10.1128/mbio.02664-20.
Повний текст джерелаДисертації з теми "TRNA Function"
Boonyalai, Nonlawat. "Lysyl-tRNA synthetase : structure-function studies." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429379.
Повний текст джерелаKelly, Paul Michael. "Characterizing the Function of Alanyl-tRNA Synthetase Activity in Microbial Translation." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586259003806337.
Повний текст джерелаDhungel, Nripesh. "tRNA Splicing Endonuclease: Novel and Essential Function Beyond tRNA Splicing and Subunit interactions." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337968400.
Повний текст джерелаSwinehart, William E. Jr. "A Biochemical Investigation of Saccharomyces cerevisiae Trm10 and Implications of 1-methylguanosine for tRNA Structure and Function." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429867956.
Повний текст джерелаRogers, Theresa Elizabeth. "Elucidating the Function of a Pseudo-tRNA in Bacillus cereus." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291213318.
Повний текст джерелаFaruggio, Dawn C. (Dawn Catherine) 1965. "Stucture-function relationships of human initiator tRNA mutants and attempted regulated expresion of tRNA genes in yeast." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/32665.
Повний текст джерелаPicchioni, Daria. "Biological function of SLIMP, a mitochondrial seryl-tRNA synthetase paralog." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/283974.
Повний текст джерелаEl nostre grup de recerca es centra en la traducció de proteïnes i més específicament en el mecanisme d’aminoacilació dels àcids ribonucleics (ARNs) de transferència (ARNt) per una família d’enzims essencials i universals anomenats aminoacil-ARNt sintetases (aaRSs). Al laboratori s’han analitzat el paper de les aaRSs en la traducció proteica, les seves funcions no canòniques, la seva evolució, així com la seva implicació en malalties humanes. Les aaRSs són components universals i essencials del codi genètic. La seva llarga historia evolutiva explica el creixent número de funcions que s’estan descobrint, tant per a elles com per a proteïnes paràlogues, més enllà del seu paper canònic en traducció genètica. Al laboratori, durant el procés d’obtenció d’un model a Drosophila melanogaster per a l’estudi de malalties humanes degudes a deficiències en l’aminoacilació d’ARNt, es va identificar un nou gen, paràlog de la seril-ARNt sintetasa (SeRS) mitocondrial, anomenat SLIMP. La proteïna SLIMP representa un nou tipus de proteïna similar a aaRS que ha adquirit una funció essencial a insectes, tot i la relativament baixa divergència respecta a una estructura d’SeRS canònica. Tot i amb això, són necessaris estudis addicionals per a identificar el paper biològic de SLIMP. Per aconseguir aquesta fita, s’ha portat a terme el projecte descrit en aquest manuscrit, el qual consisteix en anàlisis addicionals del fenotip resultant de la depleció de SLIMP in vivo, seguits d’estudis detallats de les interaccions moleculars amb àcids nucleics i proteïnes, per acabar amb un estudi dels efectes de SLIMP en la fisiologia cel•lular. En conjunt, els nostres resultats demostren que SLIMP s’uneix específicament a ARNs mitocondrials in vivo i in vitro. SLIMP interacciona amb SerRS2 i les dues són interdependents a nivell d’estabilitat proteica. La depleció de SLIMP o de SerRS2 redueix els nivells basals d’alguns ARNm mitocondrials, però la transcripció d’ARNt és manté inalterada. Es proposa un rol en la regulació post-transcripcional o en l’estabilitat dels ARNm madurs. Hem observat també que la depleció de SLIMP indueix l’aturada del cicle cel•lular en la transició G2/M. Aquests resultats suggereixen que SLIMP, o una conseqüència de la seva funció, podria tenir un paper d’enllaç entre els mitocondris i els factors de transcripció nuclears que regulen la proliferació cel•lular.
Cacan, Ercan. "Evolutionary synthetic biology: structure/function relationships within the protein translation system." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45838.
Повний текст джерелаMirando, Adam Christopher. "Characterization Of A Non-Canonical Function For Threonyl-Trna Synthetase In Angiogenesis." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/523.
Повний текст джерелаKubicek, Charles E. 1981. "Identifying targets and function of the ubiquitin related modifier Urm1 in Saccharomyces cerevisiae." Thesis, University of Oregon, 2009. http://hdl.handle.net/1794/10310.
Повний текст джерелаPost-translational modification of proteins is an important cellular method of controlling various aspects of protein activity, including protein-protein interactions, half- life, and transport. An important class of post-translational modifications involves the ubiquitin family of proteins. In these modifications, a small protein, such as ubiquitin, is conjugated to a target protein through an isopeptide bond. Conjugation by a ubiquitin family member acts as a signal to regulate the activity, function, or stability of the target protein. Urm1, a ubiquitin-like protein conserved throughout all eukaryotes, was initially identified in S. cerevisiae. Loss of Urm1 leads to the disruption of a variety of cellular processes, including oxidative stress response, filamentous growth, and temperature sensitivity. This body of work comprises efforts to identify novel targets of Urm1, the mechanism by which Urm1 is attached to target proteins, and the physiological consequences of such conjugation. To gain understanding of the function and mechanism of Urm1 conjugation, the only known conjugate of Urm1, the peroxiredoxin reductase Ahp1, was examined in an effort to identify the site of modification on Ahp1 and to evaluate the physiological consequences of urmylation of Ahp1. I then completed a series of screens--a synthetic lethal screen, a two-hybrid screen, and a protein over-expression screen--to identify novel Urm1 conjugates and cellular functions dependent on Urm1. Of particular interest were genes identified in the synthetic lethal screen, namely PTC1, which encodes a protein phosphatase, and a set of genes encoding the Elongator complex, which functions in transcriptional elongation and tRNA modification. During this time period, other groups showed that thiolation of tRNAs depends on Urm1. Thus, Urm1 does not function only in protein conjugation, but also as a sulfur carrier in the thiolation of tRNA. Interestingly, I identified Elp2, a component of the Elongator complex, as a new Urm1-conjugate. Because Elp2 is also required for tRNA modification, perhaps Urm1 plays more than one role in tRNA modification. Loss of tRNA modification may disrupt many cellular functions and could explain the variety of urm1 mutant phenotypes. I have determined that all known Urm1 dependent processes are also associated with tRNA modification.
Committee in charge: Karen Guillemin, Chairperson, Biology; George Sprague, Advisor, Biology; Alice Barkan, Member, Biology; Kenneth Prehoda, Member, Chemistry; Tom Stevens, Outside Member, Chemistry
Книги з теми "TRNA Function"
Dieter, Söll, and RajBhandary Uttam, eds. tRNA: Structure, biosynthesis, and function. Washington, D.C: ASM Press, 1995.
Знайти повний текст джерелаKnoll, Franz, and Thomas Vogel. Design for Robustness. Zurich, Switzerland: International Association for Bridge and Structural Engineering (IABSE), 2009. http://dx.doi.org/10.2749/sed011.
Повний текст джерелаSoll, Dieter. Trna: Structure, Biosynthesis, and Function. ASM Press, 1995.
Знайти повний текст джерелаSoll, Dieter, and Uttam L. RajBhandary. TRNA: Structure, Biosynthesis, and Function. Wiley & Sons, Limited, John, 2014.
Знайти повний текст джерелаDivan, Aysha, and Janice A. Royds. 3. RNA. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198723882.003.0003.
Повний текст джерелаShen, Wenyan *. Studies of the structure and function of "Bacillus subtilis" tRNAs in "Escherichia coli". 1991.
Знайти повний текст джерелаSchreiner, Helen Carol. Replication control in broad-host-range plasmid RK2: Kil and kor functions affect expression of the essential replication gene trfA. 1988.
Знайти повний текст джерелаSedel, Frédéric, and Carla E. M. Hollak. Disorders of Thiamine Metabolism. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0028.
Повний текст джерелаЧастини книг з теми "TRNA Function"
Martin, Nancy C. "Organellar tRNAs: Biosynthesis and Function." In tRNA, 127–40. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818333.ch9.
Повний текст джерелаBjörk, Glenn R. "Biosynthesis and Function of Modified Nucleosides." In tRNA, 165–205. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818333.ch11.
Повний текст джерелаMeinnel, Thierry, Yves Mechulam, and Sylvain Blanquet. "Aminoacyl-tRNA Synthetases: Occurrence, Structure, and Function." In tRNA, 251–92. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818333.ch14.
Повний текст джерелаBaron, Christian, and August Böck. "The Selenocysteine-Inserting tRNA Species: Structure and Function." In tRNA, 529–44. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818333.ch26.
Повний текст джерелаSherman, Joyce M., M. John Rogers, and Dieter Söll. "Recognition in the Glutamine tRNA System: from Structure to Function." In tRNA, 395–409. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818333.ch19.
Повний текст джерелаSchuster, Jens, and Mario Mörl. "Mitochondrial tRNA editing." In Mitochondrial Function and Biogenesis, 81–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b95713.
Повний текст джерелаMaréchal-Drouard, L., P. Guillemaut, H. Pfitzingzer, and J. H. Weil. "Chloroplast tRNAs and tRNA genes: structure and function." In The Translational Apparatus of Photosynthetic Organelles, 45–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-75145-5_4.
Повний текст джерелаSuzuki, Tsutomu. "Biosynthesis and function of tRNA wobble modifications." In Fine-Tuning of RNA Functions by Modification and Editing, 23–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/b106361.
Повний текст джерелаAlfonzo, Juan D. "Editing of tRNA for Structure and Function." In Nucleic Acids and Molecular Biology, 33–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-73787-2_2.
Повний текст джерелаShigi, Naoki. "Sulfur Modifications in tRNA: Function and Implications for Human Disease." In Modified Nucleic Acids in Biology and Medicine, 55–71. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34175-0_3.
Повний текст джерелаТези доповідей конференцій з теми "TRNA Function"
Williams, Tamara, Adam Mirando, Christopher Francklyn, and Karen M. Lounsbury. "Abstract 3897: A novel function for threonyl-tRNA synthetase as a stimulator of angiogenesis and endothelial cell migration." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3897.
Повний текст джерелаShigematsu, M., K. Pawar, T. Kawamura, D. A. Deshpande, and Y. Kirino. "Expression and Functional Role of tRNA-Derived Non-Coding RNAs in Asthma." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6114.
Повний текст джерелаHonda, Shozo, Megumi Shigematsu, Phillipe Loher, Juan P. Palazzo, Issei Imoto, Isidore Rigoutsos, and Yohei Kirino. "Abstract 2665: SHOT-RNAs: A novel class of tRNA-derived functional RNAs expressed in hormone-dependent cancers." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2665.
Повний текст джерелаYi Lee, Ching, Ching I Chen, and Meng-Cong Zheng. "User Experience of Taiwan Railway Ticket Vending Machine." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001699.
Повний текст джерелаAndreev, D. E., M. Terenin, S. E. Dmitriev, M. Niepmann, and I. N. Shatsky. "MOONLIGHTING FUNCTIONS OF GLYCYL-TRNA SYNTHETASE IN MAMMALIAN CELLS: THE ROLE IN THE TRANSLATION INITIATION ON THE IRES ELEMENTS OF ENTEROVIRUS RNAS." In Viruses: Discovering Big in Small. TORUS PRESS, 2019. http://dx.doi.org/10.30826/viruses-2019-13.
Повний текст джерелаCastilla, Andre Coutinho, Priscilla Koch Wagner, Jessicados Santos de Oliveira, Maria Fernanda Barbosa Wanderley, and Anthony Moreno Eigier. "Neuralmed trIA: Automated Screening of Urgent Findings on Head CT Scans." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.342.
Повний текст джерелаKubisz, P., S. Brahimi, and S. Cronberg. "INFLUENCE OF L0MUSTIN ON SOME PLATELET FUNCTIONS IN VITRO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643443.
Повний текст джерелаXiao, Y., E. R. Hsieh, Steve S. Chung, T. R. Chen, S. A. Huang, T. J. Chen, and Osbert Cheng. "Novel Concept of the Transistor Variation Directed Toward the Circuit Implementation of Physical Unclonable Function (PUF) and True-random-number Generator (TRNG)." In 2019 IEEE International Electron Devices Meeting (IEDM). IEEE, 2019. http://dx.doi.org/10.1109/iedm19573.2019.8993496.
Повний текст джерелаBang, K. H., and W. H. Choo. "Flow Boiling in Minichannels of Copper, Brass, and Aluminum Round Tubes." In ASME 2004 2nd International Conference on Microchannels and Minichannels. ASMEDC, 2004. http://dx.doi.org/10.1115/icmm2004-2381.
Повний текст джерелаChen, I.-Chang, Shu-Keng Hsu, Teh-Juan Wu, Li-Hsien Yen, Yusin Lee, Dung-Ying Lin, Chuen-Yih Chen, Wei-Hsun Lee, and Guo-Wei Su. "RDSP: A Railway Decision Support Platform for Integrating and Bridging Existed Legacy Systems." In 2013 Joint Rail Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/jrc2013-2442.
Повний текст джерелаЗвіти організацій з теми "TRNA Function"
Ostersetzer-Biran, Oren, and Jeffrey Mower. Novel strategies to induce male sterility and restore fertility in Brassicaceae crops. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7604267.bard.
Повний текст джерела