Дисертації з теми "TRM4"
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Schaefer, Estelle. "Contrôle spatial de la division cellulaire chez les plantes : rôle des protéines TRM6-TRM7-TRM8 d’Arabidopsis thaliana dans la formation de l’anneau de préprophase." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112042/document.
Повний текст джерелаPlant cells are embedded within a semi-rigid pecto-cellulosic cell wall that prevents cell migration. As a consequence, three-dimensional cellular organization of tissues mostly results from polarized cell division, since new cells remain in place after mitosis with no possibility for subsequent relocation. In land plants, the division plane is determined pre-mitotically, during the G2 to M phase transition by the preprophase band (PPB), a transient, premitotic microtubule array. The molecular pathways leading to preprophase band formation are still largely unknown. Our team has identified a regulatory complex, the TTP complex, composed of TON1, TRM and a Protein Phosphatase 2A complex with FASS as the regulatory subunit. Both TON1 and FASS have been shown to be involved in cortical microtubules organization during both interphase and PPB formation. The TRM super family is a newly identified protein family composed of 34 members, some of which are microtubule-associated proteins able to recruit TON1 and FASS to the microtubules. Based on TRM expression profiles and preliminary genetic analysis, we hypothesized that some TRMs could have a role in interphase, while others could be involved in PPB formation. My project was to identify and characterize TRMs specifically involved in PPB formation, if any. Transcriptomic analysis using the Genevestigator tool revealed that one TRM gene, TRM7, has a peak of expression at mitosis. TRM7 promoter GUS fusion analysis confirmed that TRM7 is expressed in all dividing tissues and in situ hybridizations of shoot apical meristems revealed a patchy pattern of expression, typical of cell cycle-regulated genes. Remarkably, the genomic TRM7-3xYFP fusion is only expressed at the G2/M transition where it localizes to the PPB, persists beyond PPB degradation until the beginning of metaphase and then disappears. To our knowledge, this makes TRM7 the only PPB-specific marker identified in plants so far, since all other PPB-associated markers label others structures as well, both interphasic or mitotic. TRM7 is part of the TRM6-7-8 sub-family, which share 74% of similarity. Phenotypic analysis of the trm7 and trm6 trm7 trm8 triple mutant revealed a major role of this sub-group in PPB formation. Almost half trm7 cells and all trm6 trm7 trm8 cells displayed an abnormal preprophase stage, the vast majority of the triple mutant cells dividing without PPB. Surprisingly, the triple mutant phenotype is rather mild compare to the severe developmental syndrome of PPB-lacking ton1 or fass plants. Moreover, although often shifted, division plane positioning is far from being fully randomized as in ton1 and fass mutants. Our results show that, for the first time, we have fully uncoupled the mitotic function of the TTP complex from its interphasic function, contrarily to other TTP mutants analyzed so far, where division and interphase defects are indistinguishable. Moreover, these findings question the central role of the PPB in division plane positioning. All TTP components share similarities with animal proteins assembled within a complex at the centrosome. In a side project, we studied the conservation of protein interactions within the animal complex and were able to find cross-interactions between animal and plant proteins in yeast two-hybrid experiments
(UPC), Universidad Peruana de Ciencias Aplicadas. "Taller de comunicación interpersonal - TR94 TR94." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623650.
Повний текст джерела(UPC), Universidad Peruana de Ciencias Aplicadas, and Trierweiller Ana Claudia Rocker. "Portugués ti2 - TR84 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623624.
Повний текст джерела(UPC), Universidad Peruana de Ciencias Aplicadas, Morris Carlos Gerardo Delgado, Salazar Elena Olga Romero, Chumbez Maria Del Rosario Salcedo, and Diez Luis Ramón Sandoval. "Taller de comunicación interpersonal - TR94 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623651.
Повний текст джерелаPleshe, Elizabeth Lei. "Investigation of ligand binding Aquifex aeolicus TrmH." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p1427768.
Повний текст джерелаHamidi, Zohal. "Characterization and Crystallization of the Mycobacterium Tuberculosis trmD." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2219.
Повний текст джерелаBarbet, Gaëtan. "Rôle du canal ionique TRPM4 dans les cellules dendritiques." Paris 7, 2009. http://www.theses.fr/2009PA077114.
Повний текст джерелаDendritic cells (DC) are central cells in immune System. DCs lead to lymphocyte activation and control adaptative immune response. To do so, DCs have to maturate and migrate toward secondary lymphoid organs where they initiate pathogen-specific lymphocyte responses. Calcium is an ubiquitous second messenger controlling a variety of cellular functions such as migration. However, the role of calcium in dendritic cells biology is poorly understood. We show that the ionic channel TRPM4 has a crucial role in calcium homeostasis in DC during stimulation. The lack of TRPM4 in DC leads to calcium overload after bacterial stimulation and dramatically decrease their migratory capacities but without affecting their maturation. We observed that a calcium overload leads to a decrease of the PLC-p2 expression which is correlated with an absence of a subsequent signalling response. Thus, this work shows the key rôle of TRPM4 in the migration but not the maturation of DC, emphasizing that these two cellular events are regulated differently
Uzzell, Jamar. "STRUCTURAL BASIS FOR THERMAL STABILITY OF THERMOPHILIC TRMD PROTEINS." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2539.
Повний текст джерелаFurter, Rolf. "Das TRP4-Gen von Saccharomyces cerevisiae : Klonierung, Struktur und Regulation /." Zürich, 1986. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7977.
Повний текст джерелаDe, Marchi Carlo. "Probabilistic Estimation of Precipitation Combining Geostationary and TRMM Satellite Data." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14068.
Повний текст джерелаWu, Qiaoyan. "Diurnal variation of tropical precipitation using five years TRMM data." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1266.
Повний текст джерелаCAMPOS, R. F. "Comparação entre dados de precipitação interpolados e do TRMM (3B43V7)." Universidade Federal do Espírito Santo, 2017. http://repositorio.ufes.br/handle/10/7592.
Повний текст джерелаAs estimativas de precipitação do satélite TRMM (Tropical Rainfall Measuring Mission) podem ser informações valiosas para áreas sem quaisquer tipos de medições da pluviosidade ou regiões com uma rede pluviométrica escassa. O objetivo do estudo foi comparar as estimativas mensais de precipitação do satélite TRMM com dados de precipitação terrestre interpolados produzidos por Xavier et al. (2015) para o Brasil. Para quantificar a concordância e parecença entre os bancos de dados foi utilizado o índice de concordância refinado de Willmout e o índice de desempenho. Os resultados indicaram que o satélite capturou adequadamente os padrões espaciais de precipitação em todo o Brasil quando comparado com a estimativa interpolada. É importante ressaltar que o satélite TRMM tendeu a superestimar os valores de precipitação, entretanto em média o acordo entre as estimativas TRMM e os dados DPTI é alto (dr ≥0,8 e Pi ≥0,7), mas observa-se maior viés em épocas chuvosas. Com base nestes resultados, a região Norte apresentou resultados mais discordantes para o Brasil. Esta região foi escolhida para o cálculo do índice de erosividade com o objetivo de visualizar a diferença da entrada dos dados interpolados com os dados do satélite TRMM no cálculo da erosividade. Os dados do satélite TRMM apresentaram menor índice de erosividade para região Norte. Isto significa que a erosividade com dados interpolados pode superestimar o real valor da erosividade nesta região, devido a limitações, como a escassa rede pluviométrica, inerentes ao banco de dados de estações interpoladas para esta região. Palavras-chave: Sensoriamento Remoto, Estatística Descritiva, Análise de concordância.
GAMA, Nicolas Alexandre. "Validação das estimativas de precipitação observadas pelo Tropical Rainfall Measuring Mission para o Brasil." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18868.
Повний текст джерелаMade available in DSpace on 2017-05-23T15:38:53Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Gama, N.A. (2016) - Validação das Estimativas de Precipitação Observadas pelo Tropical Rainfall Measuring Mission para o ~1.pdf: 9989783 bytes, checksum: cbd93ee88254c673fdb01934acc83002 (MD5) Previous issue date: 2016-03-11
CAPES
A precipitação é considerada um elemento fundamental e de grande importância no ciclo hidrológico, pois é através dela que é feita a recarga hídrica nas bacias hidrográficas e nas reservas subterrâneas.O monitoramento meteorológico é de grande importância para as nações, este monitoramento pode ser feito através de diversos métodos e instrumentos, sejam eles terrestres ou orbitais. No Brasil problemas relacionados à seca tornam-se preocupantes e estão presentes na sociedade moderna. O estudo e entendimento de comportamentos de padrões espaciais de informações sobre precipitações é uma ferramenta importante para a tomada de decisão. Observações obtidas por sensores a bordo de satélites artificiais na órbita da Terra auxiliam na medição do volume de chuva em uma dada região. Para esta dissertação foram utilizados como materiais um conjunto de dados gratuitos de precipitação do TRMM (TROPICAL RAINFALL MEASURING MISSION) através de um dos seus produtos disponíveis chamado de Rainfall Product (3B43). Atualmente estes recursos vêm sendo utilizado em diversas pesquisas onde entre suas vantagens encontram-se: a periodicidade de amostragem (resolução temporal) e abrangência superior às estações meteorológicas. Porém, as observações dos sensores orbitais apresentam algumas desvantagens como, por exemplo, a resolução espacial da informação da precipitação, sendo recomendado estabelecer critérios para as análises e validação das estimativas. Sendo assim, além de dados orbitais, informações sobre séries históricas de precipitação obtidas por estações meteorológicas que são operados por diversos órgãos públicos foram utilizadas. Desta forma, foram delineados objetivos para essa pesquisa sendo eles: (i) avaliar os dados do TRMM, a fim de valida-los como um instrumento de monitoramento de precipitação para o Brasil; (ii) comparar as informações históricas do TRMM as respectivas estações de campo em amostras no território brasileiro e assim determinar a correlação entre estes produtos; (iii) Avaliar os dados TRMM de precipitação com base no período de 2000 até 2014 aplicando um teste de normalidade a fim de verificar regiões onde existe maior igualdade estatística entre os produtos. Para a avaliação e validação dos dados do produto TRMM 3B43 em relação às séries históricas das estações meteorológicas, foram feitas análises estatísticas como a correlação entre os dados e o teste de Kolmogorov-Smirnov entre as duas Grades de informações. Espera-se através desta pesquisa contribuir com o uso e divulgação de informações temporais do TRMM para o monitoramento de precipitação no território brasileiro. Através da análise estatística entre os dois conjuntos de dados, percebeu-se que há sim a possibilidade de utilização dos dados do satélite TRMM para verificar o comportamento das curvas de precipitação, contribuindo ainda mais em regiões onde há escassez de dados in situ como o caso da região Amazônica.
Meteorological monitoring is considered very important to the nations, andthis can be done through various methods and instruments, among them are the terrestrial and orbital. In Brazil droughtrelated problems become worrisome and are present in modern society.The study and understanding of behaviors of spatial patterns about precipitations is an important tool for decision making. Observations obtained by remote sensingusing artificial satellites can give support for mesuring rainfall in a given region. The materials used in this work was a set of free rainfall data from TRMM (Tropical Rainfall Measuring Mission) considering Rainfall Product (3B43). Nowawadaysthese resources have been used in several researches presenting some advantges and between these are: sampling frequency (temporal resolution) and higher coverage compared to the insitu stations. However, there are some disadvantages, for e.g., the rainfall spatial resolution and the requirement to establish some criteria for analysis and data validatiing. Therefore, in addition to orbital data, information on historical precipitation series obtained by insitu stations that are operated by public organizations has been used. Thus, goals have been set for this research which are: (i) evaluate the TRMM data in order to validate it as a rainfall monitoring instrument for Brazil; (ii) obtain satellite TRMM historic information and in situ rainfall stations over Brazil and determine the correlation between these products; (iii) evaluate TRMM records of precipitation based during 2000 until 2014 period, and applying on them a normality test to verify regions where there is more statistical equality between the products. For the evaluation and validation of TRMM 3B43 product data in relation to historical series from in situ stations, statistical analyzes were made as the correlation between the observations using the Kolmogorov-Smirnov test between the two Grids information. It is expected through this research to contribute to the use and disclosure of TRMM temporal information for rainfall monitoring in Brazil. Through statistical analysis of the two sets of data, it was realized that there is the possibility of using the TRMM satellite data to verify the behavior of precipitation curves, further contributing in areas where there are few data in situ as the case of the Amazon region.
Ferreira, Franck. "Exploitation des données du radar de TRMM pour l'estimation de la pluie depuis l'espace." Paris 6, 2001. http://www.theses.fr/2001PA066089.
Повний текст джерелаSanderson, Victoria Louise. "An evaluation of TRMM satellite rainfall climatologies : implications for climate studies." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403605.
Повний текст джерелаGopalan, Kaushik. "A TIME-VARYING RADIOMETRIC BIAS CORRECTION FOR THE TRMM MICROWAVE IMAGER." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2435.
Повний текст джерелаPh.D.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Electrical Engineering PhD
Gueffier, Mélanie. "Rôle du canal TRPM4 dans l'hypertrophie cardiaque : utilisation d'un modèle d'entraînement." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT035.
Повний текст джерелаAbstract: Cardiac muscle is an organ that adapts to different hemodynamic stress by activating protein synthesis and increasing cardiomyocytes size, resulting in cardiac hypertrophy. The objective of this PhD is to study the potential role of TRPM4 channel in different types of cardiac hypertrophy. Impaired diastolic Ca2+ is responsible for the initial signal activating signaling pathways in a deleterious cardiac hypertrophy pathological type such as Calcineurin-NFAT pathway and the re-expression of fetal genes. This hypertrophy is first compensatory and preserves the myocardial pump function. This alteration can be carried out by various stimuli such as increased angiotensin II or by cardiovascular diseases such as myocardial infarction and hypertension.However, a beneficial cardiac hypertrophy is also described in the literature, especially during development stages during embryogenesis or even in response to regular moderate physical activity. It is characterized by the activation one different signaling pathway, the IGF-1 - PI3K –Akt, generated by an increase in growth factor levels that is the insulin growth factor -1. These signaling pathways have been widely described in the literature and cross-talking. TRPM4 channel is a nonselective cation channel permeable equally to Na+ and K+, impermeable to Ca2+ but activated by the intracellular Ca2+. In the immune system, it downregulates Ca2+ entry and therefore appears to be involve in many Ca2+-dependent cellular functions in different cell types. By the use of two models of cardiac hypertrophy, a physiological generated by four weeks of training in endurance and pathological after myocardial infarction induced by ligation of the left coronary artery on wild-type and knockout mice -out (KO) for TRPM4 channel, we have demonstrated a functional expression increased TRPM4 channel within the left ventricle associated with down-regulation of Ca2 + entry. TRPM4 the channel being a regulator of calcium homeostasis in cardiomyocytes functional expression after myocardial infarction as well as the drive promotes the activation of the pathway of IGF-1-PI3K-Akt and partially prevents the pathway activation of the NFAT-calcineurin and the development of pathological cardiac hypertrophy, in particular myocardial infarction model. Indeed, in the absence of expression of the channel, the Ca2 + is not regulated, the path of Calcineurin-NFAT is favored. Keywords: TRPM4, cardiac hypertrophy, training, IGF-1-PI3K-Akt, calcineurin
Collischonn, Bruno. "Uso de precipitação estimada pelo satélite TRMM em modelo hidrológico distribuído." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/7684.
Повний текст джерелаSimard, Christophe. "Implication du canal cationique non-sélectif TRPM4 dans l'activité électrique cardiaque." Caen, 2012. http://www.theses.fr/2012CAEN3144.
Повний текст джерелаThe TRPM4 protein, is a member of the larger family "Transient Receptor Potentiel" channels, and supports a nonselective cationique current activated by intracellular calcium (NSCCa). TRPM4 presents a large tissular distribution. In the heart, it is present in the atrium (human, rat and mouse) and sinus node (mouse), but it is only slightly expressed in the ventricle. However its ventricular expression is increased in case of cardiac hypertrophy (SHR rat). While TRPM4 cardiac mapping is well established, its implication in the cardiac activity was still unknown. Our work had for objective to estimate the implication of the TRPM4 channel in the cardiac activity, by using electrophysiological technics (intracellular microelectrode and patch-clamp). We combined a pharmacological approach, using two inhibitors of the TRPM4 (the acid flufénamique and 9-phénanthrol) and an approach of transgenesis, by using mice invalidated for the TRPM4 gene. We observed that TRPM is implied in the mice atrial action potential duration (APD), because its inhibition decreases the APD, and TRPM4-/-transgenics mice present a shorter AP than TRPM4+/+ mice. TRPM4 channel also participates in ventricular arrhythmias. We developed a model of hypoxia-reoxygenation to produce arrhythmias. The application of TRPM4 inhibitors eliminates these arrhythmias. Finally we established a link between TRPM4 mutations and Brugada syndrome. In particular, the mutation K914X giving an unfunctional channel, was identified in a patient affected by Brugada Syndrome. Our study identifies, TRPM4 as a new promising pharmacological target in the prevention of cardiac electrical disturbance
Nascimento, Diego Tarley Ferreira. "Chuvas no estado de Goiás e no Distrito Federal a partir de estimativas por satélite e circulação atmosférica." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/6023.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Avec l'avènement des nouveaux capteurs et produits de télédétection, il existe la possibilité d'appliquer des images de satellite comme une alternative à une représentation cohérente du complexe climatique, à partir du point de départ pour une analyse de la continuité spatiale. Ainsi, cette thèse de doctorat vise à fournir une étude des pluies dans l'état de Goiás et au District fédéral, en profitant des estimations des précipitations par satellite. Les procédures méthodologiques inclus la définition des années établi (années-standart) comme d'échantillons du régime habituel et des précipitations exceptionnelles, et l'utilisation d'estimations mensuelles et quotidiennes des précipitations de Mission de Mesure de Pluies Tropical (Tropical Rainfall Measuring Mission - TRMM) à et l'étude de la pluviométrie, basée sur une analyse qualitative et quantitative des données les précipitations annuelles, saisonnières, mensuelles et journalières, avec l'identification des systèmes météorologiques actifs et responsables pour la formation de la pluie. La distribution spatiale des précipitations reflète l'influence des compartiments topographiques à l'entrée et le déplacement ou même comme un obstacle à l'avancement des systèmes atmosphériques qu’il sont producteurs de pluie dans la région. La variabilité de précipitations entre les différentes années établi conduit à comprendre que l'état de sèche, normale et humide ne fait pas référence à la hauteur annuelle des précipitations, mais, surtout, la distribution des précipitations au cours des mois et la délimitation de la saison des pluies et sec. En outre, il a été mis en exergue les différentes activités et la participation des masses d'air dans la genèse des pluies sur l ‘Etat de Goiás et le District fédéral, où normalement on voit une représentation équilibrée entre les principaux systèmes atmosphériques opérant dans la région, alors que le régime sec a augmenté les performances du mTa et le régime des pluies reflète la haute performance de mEc.
Com o advento de novos sensores e produtos do Sensoriamento Remoto, surge a possibilidade de aplicação de imagens satelitárias como alternativa para uma coerente representação do complexo climático, partindo do pontual para uma análise do contínuo espacial. Sendo assim, a presente tese de doutorado teve como objetivo geral prover um estudo das chuvas no estado de Goiás e no Distrito Federal, valendo-se de estimativas de precipitação realizadas por satélite e considerando a circulação atmosférica. Os procedimentos metodológicos compreenderam a definição de anos-padrão como recortes amostrais do regime habitual e excepcional das chuvas e o uso de estimativas mensais e diárias de precipitação do Tropical Rainfall Measuring Mission (TRMM) para o estudo das chuvas, amparada numa análise quali-quantitativa dos valores anuais, sazonais, mensais e diários de precipitação, com a identificação dos sistemas atmosféricos atuantes e responsáveis pela formação de chuvas. A distribuição espacial da precipitação refletiu a influência dos compartimentos topográficos na entrada e no deslocamento ou mesmo como barreira ao avanço dos sistemas atmosféricos produtores de chuva na região. A variabilidade da precipitação entre os diferentes anos-padrão leva a entender que a condição de seco, habitual e chuvoso não se refere essencialmente à altura pluviométrica anual, mas, sobretudo, à distribuição das chuvas no decorrer dos meses e à delimitação do período chuvoso e seco. Também foi posta em evidência as diferenças de atuação e participação das massas de ar na gênese das chuvas do estado de Goiás e do Distrito Federal, em que no regime habitual percebe-se uma atuação equilibrada entre os principais sistemas atmosféricos atuantes na região, ao passo que o regime seco apresenta aumento da atuação da massa tropical atlântica (mTa) e o regime chuvoso reflete elevação da atuação da massa equatorial continental (mEc).
Nunes, Ana Maria Pereira. "Climatologia e ambiente de tempo severo na Amazônia." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/14/14133/tde-29052015-133627/.
Повний текст джерелаThe Amazon region plays a key role in climate regulation, both at the regional scale and on a global scale. Rainfall in the region is very heterogeneous, mainly because of the vast size of the Amazon. Among the systems responsible for rainfall, some stand out as extreme storm events, as can be seen in many previous studies. However, unlike the mid-latitudes, in the tropical region there is no widely acknowledged set of conditions for severe weather identification. This study seeks to identify a criterion for identifying severe weather in the Amazon region from the database Precipitation Features (PF) - 1998-2012 - generated and stored by the University of Utah, based on the TRMM satellite data. This study will also attempt to identify synoptic features associated with the occurrence of these events through compositions using the reanalysis NCEP CFSR data. Using the PCTF subset of Level 2 of PF database, the criteria established for identifying severe cases include: 1) systems with 80 or more pixels PCT85 GHz <250 K; 2) systems with one or more pixel with PCT85 GHz <100 K; 3) systems with convective rain volume greater than 1000 km2 mm/h and 4) at least one record of lightning. Comparing the systems selected by this criterion with the Mesoscale Convective Systems already cataloged it can be seen that the seasonal distribution is similar, although the stations with the highest number of cases are the transition seasons (spring and fall, 429 and 223 cases, respectively). Analyzing high rates of rays found in these systems, it is clear that the criterion truly selects severe cases. With the Amazon region divided into six sub-regions and cases accumulated by quarter (JFM, AMJ, JAS, OND) South of the Amazon sub region (SA) accounts for the largest number of cases, with a total of 271 for the period of study, OND quarter with higher occurrence (135), the lowest AMJ (29). The month of October draws attention to this sub-region as the month with the highest number of cases, totaling 59, of which 83% occur after 12 local time. These cases have been investigated in compositions, as well as cases observed after 12 local time in October for Amazon Central subregion (CA). In general: 1) SA has larger area with average stronger shear (8 m/s) than AC, especially for 00Z, 06Z and 12Z; 2) average wind positive divergence values at 200 hPa were more significant for CA than for SA; 3) Wind convergence at 950 hPa is more obvious for SA than at CA and 4) is predominantly CA moster at low levels than SA. Histograms with specific values for each of these cases, both sub regions are presented in order to help identify predictors for these cases. The severe weather identification criterion in the Amazon proves efficient, while the wind shear between 500-850 hPa and wind convergence in 950 hPa stand out as important parameters in the SA region, where there is greater occurrence of severe storms.
Tang, Yue-bun Alan, and 鄧裕斌. "Molecular and functional characterization of a testis-specific TRS4 gene in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43572169.
Повний текст джерелаYoshida, Marcos Cézar. "Estudo de células convectivas em Rondônia durante o experimento WETAMC-LBA/TRMM." Instituto Nacional de Pesquisas Espaciais, 2002. http://urlib.net/sid.inpe.br/iris@1905/2005/08.03.21.22.
Повний текст джерелаThis study analyzes the three-dimensional behavior of the convective rain on the state of Rondônia and vicinity during the first Wet Season Atmospheric Mesoscale Campaign (WETAMC) of the Large Scale Biosphere-Atmosphere Experiment in Amazonia (LBA) and concomitantly with the validation of the Tropical Rainfall Measuring Mission (TRMM). The analysis was done from January to February, 1999 period. Rain images from the Precipitation Radar (PR) onboard of the TRMM satellite, Rebio Jaru radiosonde data, Geostationary Operational Environmental Satellite-8 (GOES-8) infrared images and National Center for Enviroment Predictions/National Center for Atmospheric Research(NCEP/NCAR) wind and humidity fields were used for characterizing the convective activity. In the analyses of the vertical behavior of convective cells, following an adopted intensity criterium, it was selected only the strong and intense cells in their mature stage to obtain the zonal and meridional average vertical profiles of rain. From the average profiles, the convective cells were classified as shallow, medium and deep. To analyze the horizontal distribution of the convective storms and the associated diurnal cycle of rainfall, the region Rondônia was subdivided in three subregions. Additionally, each rain event was classified as: singlecell, multicell and supercell storms. From the horizontal and vertical behavior of the convective storms, it was observed that the prevailing events are: multicells (58,3%), singlecells (25,0%) and supercells (16,7%). It stands out that in the case of supercells the convective depth tend to be shallow, while singlecells and multicells events are relatively well distributed between shallow and deep. A case study of a supercell storm occurred in northen Rondônia on the 25 of January was also analyzed. In this case, variables such as the lift index (Li), k index (Ki), convective available potential energy (CAPE), mixing rate (r) and the equivalent potential temperature (_e) indicate that the event occurred in an ambient thermodynamically favorable for the storm development.
Soares, Alexleide Santana Diniz. "Avaliação das estimativas de chuva do satélite TRMM no estado da Paraíba." Universidade Federal da Paraíba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/5530.
Повний текст джерелаConselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
The spatial and temporal variability is a precipitation feature and constitutes a factor of complexity for developing rainfall studies. Moreover, the low density of rain gauge stations and errors in data collection in the field increase the difficulties in implementing studies in this research area. However, such researches are essential considering that it is from them that we can carry out flood and drought forecasts, understand the hydrological regime of rivers, soil moisture, temperature changes, among others. Thus, the spatial rainfall estimates obtained through satellites data are important because, although present uncertainties, when compared with punctual data measured in the field can provide good indicators of the spatial distribution of rainfall for a given area. In this research, we evaluate the potential of rainfall estimates from TRMM (Tropical Rainfall Measuring Mission) sensor to represent the spatio-temporal variability of precipitation in the State of Paraíba, in the Northeast of Brazil. In this study we considered daily time series of 14 years length of rainfall data collected by AESA (Agência Executiva de Gestão das Águas do Estado da Paraíba) in 269 rainfall gauges and rainfall data estimated from TRMM satellite for a spatial mesh of 198 grid points covering the Paraíba State and which have been interpolated to the rain gauge locations using the inverse squared distance method. Comparisons were made considering the accumulated rainfall in different periods of time: daily, three days, seven days and monthly. With respect to spatial factors, the comparisons were developed based on punctual values in rain gauges stations, areal averages over sub-basins and mesoregions, and topographic profile. The statistical analyzes of comparison between the observed and estimated rainfall were developed based on the average rainfall, the linear correlations, the mean absolute error and root mean square error considering each accumulated period. Regarding the daily precipitation, the majority of the rain gauges (91%) showed correlation coefficients ranging from 0.5 to 0.7. This correlation increases for considering 3 days-rainfall, with values ranging from 0.5 to 0.7 in 56% of rain gauges, and of 0.7-0.8 for 42% of rain gauges. For the 7 days-rainfall, 58% of the rain gauges presented correlations ranging from 0.7 to 0.8, while for the monthly rainfall 95% of the rain gauges obtained correlations higher than 0.8. Therefore, the results indicate that the TRMM satellite provides better estimates when data are accumulated in larger time intervals. The monthly analysis showed that March and April are the months with higher correlation between observed and estimated precipitation, and that in the first months of the year the estimated and observed values have better approximations for all types of analyzes. It was also verified a good estimation potential in the analysis of seasonal variability of precipitation. Moreover, it was observed that the satellite presents the largest errors in the areas with the largest amount of rainfall. In the sub-basins and in the mesoregions of the state the rainfall regime was estimated quite closely. We concluded that the TRMM satellite presents very good skill in reproducing the observed rainfall measured in the gauge stations over the Paraíba state, becoming an important data source for helping the water resources planning and decision making
A variabilidade temporal e espacial, que é um elemento característico da precipitação pluvial se configura como um fator de complexidade para as pesquisas sobre chuvas. Além disso, a baixa densidade de postos pluviométricos e os equívocos nos processos de coleta em campo aumentam as dificuldades na execução de estudos nessa área de pesquisa. No entanto, tais pesquisas são essenciais tendo em vista que é a partir delas que se pode fazer previsão de enchentes e estiagens, compreender o regime hidrológico dos rios, a umidade do solo, as mudanças de temperatura, dentre outras. Assim, as estimativas espaciais de precipitação realizadas por satélites são técnicas importantes, pois, embora contenham incertezas, quando comparadas com valores pontuais medidos em solo podem fornecer bons indicativos da distribuição espacial das chuvas para uma determinada área. Nesta pesquisa, avalia-se o potencial das estimativas de chuva do satélite TRMM, versão 7 e 3B42 (Tropical Rainfall Measuring Mission) para representar a variabilidade espaço-temporal da precipitação no Estado da Paraíba, no Nordeste do Brasil. No estudo considerou-se séries temporais de dados diários para um período de 14 anos (1998-2011) fornecidas pela AESA (Agência Executiva de Gestão das Águas do Estado da Paraíba) referentes a 269 postos pluviométricos e dados estimados pelo satélite TRMM numa malha espacial de 198 pontos que cobrem o Estado da Paraíba e que foram interpolados para os locais de observação de campo pelo método do inverso do quadrado da distância. As comparações foram realizadas considerando a chuva acumulada em diferentes períodos: diário, três dias, sete dias e mensal. Com relação aos fatores espaciais, os comparativos foram desenvolvidos com base em valores pontuais nos locais de observação, médias espaciais considerando sub-bacias, mesorregiões, e perfil topográfico. As análises estatísticas de comparação entre a chuva observada e a estimada foram desenvolvidas a partir das médias de chuva, das correlações lineares, do erro médio absoluto e da raiz do erro médio quadrático considerando cada período acumulado. Nas análises da chuva diária a maioria dos postos (91%) apresentou índices de correlação variando de 0,5 a 0,7. Esta correlação aumenta para os acumulados de 3 dias, com valores que variam de 0,5 a 0,7 em 56% dos postos pluviométricos e de 0,7 a 0,8 em 42% dos postos. Nos acumulados de 7 dias, 58% dos pluviômetros apresentaram correlações que variam de 0,7 a 0,8 e nos acumulados mensais 95% dos postos apresentam correlações superiores a 0,8. Portanto, os resultados indicam que o satélite TRMM apresenta melhores estimativas quando os dados estão acumulados em intervalos maiores de tempo. Na análise mensal verificou-se que março e abril são os meses mais significativos de estimação e que nos primeiros meses do ano os valores estimados e observados apresentam melhores aproximações para todos os tipos de análises. Identificou-se também bom potencial de estimação na análise da variabilidade sazonal de precipitação. Além disso, observou-se que o satélite apresenta os maiores erros para as áreas onde ocorrem os maiores volumes de chuva. Nas sub-bacias e nas mesorregiões do Estado, o regime de chuvas foi estimado com bastante fidelidade em todas as formas analisadas. Conclui-se que o satélite TRMM apresenta bom desempenho para reproduzir as chuvas observadas em pluviômetros no Estado da Paraíba, configurando-se como uma importante fonte de dados para o auxílio no planejamento e na tomada de decisões relativas aos recursos hídricos
Tang, Yue-bun Alan. "Molecular and functional characterization of a testis-specific TRS4 gene in spermatogenesis." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43572169.
Повний текст джерелаHermann, Scott A., Mark A. Wigent, and Tomas C. Chavez. "Pacific Ranges Interoperable Test & Evaluation Capabilities (PRITEC)." International Foundation for Telemetering, 2009. http://hdl.handle.net/10150/606152.
Повний текст джерелаThe office of the Defense Test Resources Management Center (DTRMC) has developed two major programs to achieve Joint/Interoperable exercises between DoD test and training ranges. Joint Mission Environment Test Capability (JMETC) defines a LVC environment in which Joint operations take place, while the Test and Training Enabling Architecture (TENA) defines the communication within that environment. Putting these programs to everyday use has been a challenge for the ranges. The Pacific Missile Range Facility (PMRF) is executing the Central Test & Evaluation Investment Program (CTEIP) sponsored Pacific Ranges Interoperable Test & Evaluation Capabilities (PRITEC) project designed to develop a set of tools that will facilitate implementation of JMETC and TENA. This paper will discuss the PRITEC project in detail.
Raoof, Saad Mahmood. "Bond between textile reinforced mortar (TRM) and concrete substrate." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44141/.
Повний текст джерелаBernardi, Ewerthon Cezar Schiavo. "QUALIDADE DAS ESTIMATIVAS DE PRECIPITAÇÃO DO SATÉLITE TRMM NO ESTADO DO RIO GRANDE DO SUL." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/7658.
Повний текст джерелаUnderstanding the spatial and temporal rainfall occurrence, improves the water resources management, both in order to prevent losses related to the occurrence of floods and droughts events, as in relation to the supply of the various sectors. Thus, satellite rainfall estimates are an alternative to obtain representative data of large areas, since the gauge data from meteorological stations are scarce, frequently due the low density of stations per area. However, these satellite products contain uncertainties when compared to gauge data. In this way, this study aims to evaluate the representativeness of rainfall estimates derived from satellites in the Rio Grande do Sul state. To this, were used satellite TRMM (3B42 V7) products, which were compared with gauge data in the State provided by the Agência Nacional de Águas and by the Instituto Nacional de Meteorologia, considering the period from 1998 to 2013. This paper compared rainfall estimates and gauge data was accomplished through a set statistics like skill scores, such as event detection percentage (PC), hit rate (H), false alerts ratios (FAR and F), critical success index (CSI), the ratio of planned events and observed (B), and the indexes of Heidke (HSS) and Pierce (PSS). Some equations were applied too: correlation coefficient (r) mean absolute error (MPE), root mean square error (RMSE), the Nash-Sutcliffe efficiency coefficient (NS) and bias. The data were compared in daily and accumulated series of 15 and 30 days, through the following methods: Pixel to Point, Point to Point, Pixel to Pixel, from Sub-pixels and aggregate analysis. The 3B42 products were also evaluated for their skill to determine heavy rainfall, using as reference intensity-duration-frequency equations (IDF) derived from gauge data. The results obtained by the methods, except for the analysis of heavy rainfall, not differ much from each other. Spatial analysis showed the relationship of assessments estimates has to the density of stations and the regions of Rio Grande do Sul, while specific analyzes indicated the good performance of TRMM even in Pixel to Point comparison. The results improved in steps that the daily series were accumulated in 15 and 30 days. It was evident the decrease of the quality of the estimates in the eastern RS region, where the ocean effects generates overestimates.
A compreensão da ocorrência espacial e temporal da precipitação pluviométrica permite melhorar a gestão dos recursos hídricos, tanto no sentido de prevenir prejuízos relacionados à ocorrência de eventos de enchentes e estiagens, quanto em relação ao suprimento dos diversos setores. Assim, estimativas de precipitação de satélites são uma alternativa para obtenção de dados representativos de extensas áreas, tendo em vista que os dados observados em estações meteorológicas são escassos muitas vezes. Todavia, estes produtos de satélite contêm incertezas quando comparados aos dados medidos. O estudo procura avaliar a representatividade das estimativas de chuva oriundas de satélites no estado do Rio Grande do Sul. Para tal utilizaramse produtos do satélite TRMM (3B42 V7), que foram comparados com observados no Estado, disponibilizados pela Agência Nacional de Águas e pelo Instituto Nacional de Meteorologia, no período de 1998 a 2013. O trabalho consistiu em comparar dados de precipitações estimadas e observadas por meio de um conjunto de índices de desempenho, tais como o percentual de detecção de eventos (PC), percentual de acertos (H), percentual de falsos alertas (FAR e F), índice de sucesso crítico (CSI), a razão entre eventos previstos e observados (B), bem como os índices de Heidke (HSS), e Peirce (PSS). Além de outras equações como: coeficiente de correlação (r) erro médio absoluto (EMA), erro médio quadrático (EQM), o coeficiente de eficiência de Nash-Sutcliffe (NS) e viés. Os dados foram comparados em séries diárias e acumulados de 15 e 30 dias, por meio dos seguintes métodos: Pixel a Ponto, Ponto a Ponto, Pixel a Pixel, a partir de Sub-pixels e Análise agregada. Os produtos 3B42 também foram avaliados em relação a capacidade de determinar chuvas intensas, usando como referência equações de intensidade-duração-frequência derivadas de dados observados. Os resultados obtidos pelas metodologias, com exceção da análise de precipitações intensas, não diferenciaram muito entre si. As análises espaciais mostraram a intimidade das avaliações das estimativas tem com a densidade de postos e com as regiões do Rio Grande do Sul, enquanto as análises pontuais indicaram a boa performance do TRMM mesmo na comparação Pixel a Ponto. A medida que as séries diárias foram acumuladas em 15 e 30 dias, os resultados melhoraram. Ficou evidente o decréscimo da qualidade das estimativas na região Leste do RS, onde os efeitos da maritimidade acabam gerando superestimativas.
Paula, Stefany Correia de. "PRECIPITAÇÃO ESTIMADA POR SATÉLITE PARA USO EM MODELO CONCENTRADO CHUVA-VAZÃO APLICADO EM DIFERENTES ESCALAS DE BACIAS." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/7906.
Повний текст джерелаIn Hydrological rainfall-runoff models, rainfall is one of the main variables analyzed before being used as input data. However, its peculiar characteristics of occurrence make it challenging to measure, especially for developing countries, since it requires monitoring networks with high spatial and temporal resolutions. To overcome such problems, the use of remote sensing to estimate rainfall is being gradually diffused, with results considered of good reliability. In this sense, the objective was to evaluate the results generated by a rainfall-runoff modeling, using precipitation information estimated by the TRMM satellite, applied to four watersheds of different scales. To achieve this objective was used the concentrated model IPH II in the version for Windows® (WIN_IPH2 version 2, denominated in this work as WIPH2). In a first analysis, conducted for the watersheds of the rivers Turvo (1,540 km2), Ijuí (9,450 km2), Jacuí (38,700 km2) and Alto Uruguai (61,900 km2), which are located in southern Brazil, it was observed that the precipitation estimates provided by the TRMM satellite generated consistent spatialized mean rainfall in relation to the generated by rain gauges networks. Were found errors about 7.5% (Ijuí River watershed) to 15% (Turvo River, Jacuí River and Alto Uruguai watersheds). In overall, the daily mean rainfall, generated by the TRMM estimates, increased their correlation with the rain gauges information, as there was an increase in the watershed drainage area. In the modeling, it was noted that the WIPH2 showed good fit for the simulation of flows in the selected watersheds, with exception to the application in the Alto Uruguai watershed. In some cases, even though the mean rainfall estimated by the TRMM had generated greater uncertainty regarding the data generated by the different rain gauge networks, the model was able to compensate the deficiency of this information, by changing parameters within limits considered acceptable for the characteristics watershed. It was found that, in overall, precipitation estimated by the TRMM produced improvements in the flow evaluation coefficient (Nash-Sutcliffe NS, and correlation R coefficients), as there was an increase in the watershed drainage area until the Jacuí River watershed, with a decrease of the coefficients for the Alto Uruguai watershed, which was probably caused by the inadequacy of the WIPH2 concentrated model to the heterogeneous characteristics of the last watershed. In places with good rainfall monitoring coverage, the satellite estimates produced lower results than those generated by information measured by rain gauges. In places where the lack of equipment is accentuated and/or their distribution is non-uniform, the use of satellite estimates proved to be more reliable, reaching clearly superior results. In this sense, it was concluded that the TRMM satellite estimates may present as good alternatives to watersheds with scarce rainfall information measures on the ground, having great chances to show better results when compared to information of rain gauges scarce and poorly distributed.
Nos modelos hidrológicos chuva-vazão, a precipitação é uma das principais variáveis analisadas antes de ser utilizada como informação de entrada. Entretanto, suas características peculiares de ocorrência a tornam de mensuração desafiadora, principalmente para países em desenvolvimento, já que requer redes de monitoramento com elevadas resoluções espaciais e temporais. Para contornar tais problemas, o uso do sensoriamento remoto para estimar precipitações está sendo aos poucos difundido, com resultados considerados de boa confiabilidade. Neste sentido, objetivou-se avaliar os resultados gerados por uma modelagem chuva-vazão, utilizando-se de informações de precipitação estimadas pelo satélite TRMM, aplicada a quatro bacias hidrográficas de diferentes escalas. Para isso foi utilizado o modelo concentrado IPH II, na versão para Windows® (WIN_IPH2 versão 2, denominado neste trabalho como WIPH2). Em uma primeira análise, realizada para as bacias hidrográficas dos rios Turvo (1.540 km2), Ijuí (9.450 km2), Jacuí (38.700 km2) e Alto Uruguai (61.900 km2), localizadas na região sul do Brasil, observou-se que as estimativas de precipitação fornecidas pelo satélite TRMM geraram chuvas médias espacializadas consistentes em relação às geradas pelas redes de pluviômetros, apresentando erros de volume na ordem de 7,5% (bacia do Rio Ijuí) a 15% (bacias dos rios Turvo, Jacuí e Alto Uruguai). Em geral, as chuvas médias diárias, geradas pelas estimativas do TRMM, aumentaram suas correlações com as informações de pluviômetros, conforme houve um aumento da área de drenagem da bacia hidrográfica. Na modelagem, notou-se que o WIPH2 mostrou bom ajuste para a simulação das vazões nas bacias selecionadas, com ressalvas à aplicação na bacia do Alto Uruguai. Em alguns casos, mesmo que a precipitação média estimada pelo TRMM possuísse maior incerteza com relação aos dados gerados pelas diferentes redes de pluviômetros, o modelo conseguiu compensar a deficiência desta informação, por meio da alteração de parâmetros, dentro de limites considerados aceitáveis para as características das bacias hidrográficas. Verificou-se que, em geral, as precipitações estimadas pelo TRMM produziram melhoras no coeficiente de avaliação das vazões (coeficientes de Nash-Sutcliffe NS, e de correlação - R), à medida em que houve um aumento da área de drenagem da bacia hidrográfica até a bacia do Rio Jacuí, com decréscimo dos coeficientes para a bacia do Alto Uruguai, que provavelmente foi causado pela falta de adequação do modelo concentrado WIPH2 às características heterogêneas da última bacia. Em locais com boa cobertura de monitoramento pluviométrico, as estimativas de satélite produziram resultados inferiores aqueles gerados por informações mensuradas em solo; já em locais onde a escassez de equipamentos é acentuada e/ou sua distribuição é não-uniforme, a utilização de estimativas de satélite se mostrou mais confiável, chegando a resultados visivelmente superiores. Neste sentido, concluiu-se que as estimativas do satélite TRMM podem se apresentar como boas alternativas para bacias com escassez de informações de precipitação medidas em solo, tendo grandes chances de apresentarem melhores resultados quando comparadas com informações pontuais escassas e mal distribuídas.
So, Kam-hei, and 蘇錦熙. "A study on the role of temperature repressed sequence 4 (Trs4) in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47310704.
Повний текст джерелаpublished_or_final_version
Obstetrics and Gynaecology
Master
Master of Philosophy
Eckstein, Eugenia [Verfasser], and Frank [Akademischer Betreuer] Zufall. "Trpm4 and Trpm5 in the murine olfactory system / Eugenia Eckstein ; Betreuer: Frank Zufall." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1203128940/34.
Повний текст джерелаWu, Yu [Verfasser], and Peter [Akademischer Betreuer] Heisig. "Ion channel TRPM4 activity and cardiac conduction disease / Yu Wu. Betreuer: Peter Heisig." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1030365644/34.
Повний текст джерелаDeMoss, Jeremy. "Changes in Tropical Rainfall Measuring Mission (TRMM) retrievals due to the orbit boost estimated from rain gauge data." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1732.
Повний текст джерелаCollier, Jonathan Craig. "Tropical precipitation simulated by the NCAR Community Climate Model (CCM3): an evaluation based on TRMM satellite measurements." Texas A&M University, 2004. http://hdl.handle.net/1969.1/2715.
Повний текст джерелаEl, Euch Sami. "Validation des pluies de surface estimées par le satellite TRMM et le radar au sol WSR-88D dans le Nord-Est du Mexique." Mémoire, Université de Sherbrooke, 2009. http://savoirs.usherbrooke.ca/handle/11143/2592.
Повний текст джерелаTsutsui, Yusuke. "Development of Contactless Conductivity Measurement System with Microwave Probe and Its Applications for Organic Semiconductors." Kyoto University, 2019. http://hdl.handle.net/2433/242530.
Повний текст джерелаTetta, Zoi. "Shear strengthening of concrete members with Textile Reinforced Mortar (TRM)." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43314/.
Повний текст джерелаZagrodnik, Joseph P. "Comparison and Validation of Tropical Rainfall Measuring Mission (TRMM) Rainfall Algorithms in Tropical Cyclones." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/903.
Повний текст джерелаHof, Thomas. "Implication du canal cationique non-sélectif TRPM4 dans l’activité électrique du tissu conducteur cardiaque." Caen, 2015. http://www.theses.fr/2015CAEN2022.
Повний текст джерелаLi, Yao. "Contributions of TRPM4 and Rho Kinase to Myogenic Tone Development in Cerebral Parenchymal Arterioles." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/464.
Повний текст джерелаEl, Houfi Younas. "PKCα interagit avec la sous-unité catalytique de la m1A58 ARNt méthyltransférase Trm6-Trm61". Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T008/document.
Повний текст джерелаProtein kinase C alpha (PKCα) is a ubiquitous serine/threonine kinase. It is involved in the regulation of various cellular functions by interacting with many intracellular proteins. Among these, we were able to identify Trm61, the catalytic subunit of the tRNA m1A58 methyltransferase which plays an essential role in the stability of the tRNAiMet. Localization studies of PKCα, Trm6 and Trm61 demonstrated that these two subunits do not always share the same subcellular compartment: while Trm6 is strictly nuclear, Trm61 is both in the nucleus and in the cytoplasm where it co-localizes with PKCα. We also provided the evidence that the increased expression of PKCα induces a decrease in that of Trm61, while reduced PKCα expression is accompanied by an increase in both Trm61 and tRNAiMet levels. These changes in expression are accompanied by a significant increase in cell proliferation at high-density. This work has also shown that Trm61 subunit is essential for the survival of the C6 glioma cell line. Our results suggest that Trm6 is the essential determinant of functional tRNA m1A58 methyltransferase level and we discuss the possibility of a secondary role for cytoplasmic Trm61 in the regulation of the proliferation independently of Trm6-Trm61 action. Interestingly, human grade II and III gliomas expressed higher levels of PKCα mRNA than glioblastomas and inversely for TRM6 and TRM61 mRNA levels, arguing for a relevance of our observations for human gliomagenesis
Létoquart, Juliette. "Etudes structurales et fonctionnelles de complexes entre Trm112 et différentes méthyltransférases impliquées dans la traduction." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114821/document.
Повний текст джерелаProtein synthesis is a central process in the cell; it ensures the transfer of genetic information from mRNA in to protein. A lot of actors are involved directly or indirectly in translation. In Eukaryotes, Trm112, a small protein, interacts with and activates four methyltransferases modifying direct actors of translation. The termination factor eRF1 is methylated by the Mtq2-Trm112 complex, the 18S rRNA by Bud23-Trm112 and some tRNA by the Trm9-Trm112 and Trm11-Trm112 complexes. During this work, the crystal structures of Trm9-Trm112 and Bud23-Trm112 complexes from yeast were solved. The comparative analysis of these two new structures with Mtq2-Trm112 structure highlights the structural plasticity allowing Trm112 to interact through a very similar mode with its partners although those share less than 20% sequence identity. In the same organism, the key residues for the interaction with Trm112 are conserved or share similar characteristics. In addition to the structural analysis, the function of the Trm9-Trm112 complex was studied in S. cerevisiae. This analysis allowed to map the active site of the enzyme and to propose a model of its mechanism of action. Finally, the first data obtained in vivo, with the Archaea Haloferax volcanii suggest that the Trm112 platform might also be present in some prokaryotic organisms
Macedo, Luana Ribeiro. "O impacto do uso da técnica de assimilação de dados 3DVAR nos prognósticos do modelo WRF." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/111855.
Повний текст джерелаThe use of meteorological data assimilation technique is extremely important for the correction of the imprecisions of observational data for the initial and boundary conditions of weather forecasting models. In the present work it is used the 3DVAR data assimilation technique of the mesoscale model WRF system (Weather Research and Forecasting) aiming the analysis of the impact of the assimilation of meteorological data from several data sources (GTS - Global Telecommunication System, automatic surface stations network and radar) in the WRF model. To analysis the consistency of the data in the WRF assimilation it has been gathered the difference between analysis, with and without data assimilation. Confirming its consistency the procedures required, to generate predictions with data assimilation for each individual case were performed. The data assimilation experiments were performed for each data type as well as including all of them allowing, therefore, the analysis of the impact of each over the forecast. The results were compared and validated using data from the spatially global forecasting model GFS (Global Forecast System), satellite and the mission of the Tropical Rain Measurement (TRMM) data. The cumulative rainfall variable was compared spatially with data from TRMM, where it has been observed, in the case of January, an overestimation of the accumulated values for some regions and an underestimation for the case of April. These have been occurred because of temporal frequency of the TRMM satellite data - which probably because were not compatible with the precipitation time occurrence. Comparison between the accumulated precipitation with data from automatic station presented mostly effective results. Also, in the case study of the January with assimilated data, produced an improvement in the intensity as well as in the location of the convective cell. The wind and temperature variables were compared with the spatially GFS’s analysis. The higher temperature variable values presented alternated, from higher and lower values compared to the GFS results. The results were nevertheless unsatisfactory, because the simulated temperatures presented prior to passing the frontal system and after passing it. For the wind field there was a small discrepancy in all simulations regarding the magnitude, but the wind direction was plotted consistently simulating up to the present in the case of April cyclone. For the vertical profiles of temperature and dew point temperature the impact of data assimilation was small, but both simulations made represented good profiles, compared with the observed values. In summary, the study shows that, although there were some inconsistencies, compared with the observations, the 3DVAR assimilation contributes significantly to WRF model forecasts.
Casey, Sean Patrick. "The frequency of tropical precipitating clouds as observed by the TRMM PR and ICESat/GLAS." Thesis, [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1895.
Повний текст джерелаYeung, Seen-yu Aurora, and 楊善如. "Regulation and functional studies of the testis-specific temperature-related sequence 4 (TRS4) in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208024.
Повний текст джерелаpublished_or_final_version
Obstetrics and Gynaecology
Master
Master of Philosophy
ANJOS, Rafael Silva dos. "Qualidade de dados do satélite TRMM para espacialização das chuvas na microrregião de Itaparica-PE." Universidade Federal de Pernambuco, 2017. https://repositorio.ufpe.br/handle/123456789/24919.
Повний текст джерелаMade available in DSpace on 2018-06-26T19:43:40Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) DISSERTAÇÃO Rafael Silva dos Anjos.pdf: 4953479 bytes, checksum: 4dd93952c818268c270b34bcc3a11a07 (MD5) Previous issue date: 2017-02-02
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A proposta dessa dissertação foi avaliar as estimativas do satélite TRMM na microrregião de Itaparica, localizada no semiárido pernambucano, mostrando-a como alternativa para complementação de dados de precipitação. A presente pesquisa está dividida em três etapas principais: averiguação das diferenças entre as estimativas e os dados observados em toda Microrregião de Itaparica, análise do comportamento das taxas de chuvas convectivas e estratiformes e sua relação com a qualidade das estimativas em Belém de São Francisco, e o estudo da distribuição espacial das chuvas, utilizando o Precipitation Radar. Para isso foram utilizados dados dos postos pluviométricos, taxas dos tipos de chuvas estratiformes e convectivas (Algoritmo 3A25), estimativas mensais de precipitação (Algoritmo 3B43) além do mapeamento da precipitação em três dimensões (2A25) para posteriormente fazer o processo de interpolação dos dados e análise estatística. Foi identificado que as diferenças entre as estimativas e os dados possuem variações espaço-temporais de acordo com algumas variáveis: quantidade precipitada, localização geográfica, série histórica. Além disso foi verificado que as taxas de chuvas convectivas e estratiformes apresentam maiores índices durante a estação chuvosa, podendo estar relacionadas com os erros mensais das estimativas totais de precipitação. Com a análise das estimativas do Precipitation Radar foi possível fazer uma análise prévia da distribuição horizontal e vertical das nuvens e sua relação com fatores climáticos.
The propose of this dissertation it was to evaluate the estimates of the TRMM satellite in Itaparica Microregion, localized at semiarid of Pernambuco, and to show how the estimates could be used for complementation of observed dates. The present research is divided in three principal steps: recognition of the differences between the estimates and observed dates, analyze of the behavior of rates of convective and stratiform rains and their relation with the quality of the estimates in Belém de São Francisco, and the application of Precipitation Radar to analyze of rains spatial distribution. For this, it was utilized dates of rain gauges, rates of stratiform and convective rain (Algorithm 3A25), monthly precipitation estimates (Algorithm 3B43), including the mapping 3D rain (2A25). With this dates, it was made the interpolations and statistics analyses. It was identified that the differences between the estimates and the observed dates have space-temporal variations, according with some factors: precipitation quantity, geographic localization, historic series. Besides, it was verified that the convective and stratiform rates had the biggest indices during the rainy season, it may be connected with the monthly errors of the precipitation estimates. Through analyzes of Precipitation Radar estimates, it was possible to make an previous observation of vertical e horizontal distribution of the clouds and your relations with climatic factors.
Viana, Denilson Ribeiro. "Comportamento espaço-temporal da precipitação na Região Sul do Brasil utilizando dados TRMM e SRTM." Instituto Nacional de Pesquisas Espaciais (INPE), 2009. http://urlib.net/sid.inpe.br/mtc-m18@80/2009/05.07.19.05.
Повний текст джерелаThis work investigates the space-temporal behavior of rainfall in Southern Brazil during the 1988 and 2007 period. The evaluation was based on three features: 1) climatological aspects, 2) geographic trends from relief features, and 3) main variability modes. Two complementary data sets of rainfall were used: rain gauges and rainfall estimates from the Tropical Rainfall Measuring Mission (TRMM), product 3B43. The assessment of relief features was made using the Digital Elevation Model (MDE) from Shuttle Radar Topography Mission (SRTM), where three sub regions were identified: 1) Litoral (seacoast), 2) Campanha (countryside), and 3) Planalto (plateau). The rainfall climatological features were evaluated using basic statistics parameters. The trend geographic analysis was made for each sub region identified by multiple linear regression of rainfall versus their coordinates (latitude and longitude). The rainfall variability was evaluated by Empirical Orthogonal Functions (EOF), while the weather systems analysis associated with the EOF modes were based on Climanálise, from INPE/CPTEC. The climatological analysis show that rainfall amount is decreasing during the southern winter period, but it is increasing in the transition seasons, mainly in the southern spring. The standard deviations from the average were between 40% and 70%. The rainfall trend was most expressive in the warmest half of the year in Litoral sub region, because of South Atlantic Convergence Zone (ZCAS) and orographic precipitation. In the coldest months, the trend was more pronounced in Campanha due to frontal systems and extratropical cyclones. In the Planalto sub region, the trend was moderate in the summer due to ZCAS location, and in the autumn due to frontal systems and extratropical cyclones. The main modes of the observed rainfall variability in Southern Brazil have different causes. In the winter, the action of semi-stationary frontal systems was favored by blocking episodes. Also in the winter and transitions seasons, extratropical cyclones in association with frontal systems play an important role to the observed rainfall amount. In the warmest months, Mesoscale Convective Complexes was mainly responsible for the observed variability in the period.
Fan, Tai-Fang. "Net Surface Flux Budget Over Tropical Oceans Estimated from the Tropical Rainfall Measuring Mission (TRMM)." W&M ScholarWorks, 2003. https://scholarworks.wm.edu/etd/1539626825.
Повний текст джерелаFensterseifer, Cesar Augusto Jarutais. "QUALIDADE DAS ESTIMATIVAS DE PRECIPITAÇÕES DERIVADAS DE SATÉLITES NA BACIA DO ALTO JACUÍ-RS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/7820.
Повний текст джерелаThe continuous increase in using satellite precipitation estimates as alternative sources for data have been increasing with the new technology of the devices. Therefore, the need for evaluating the quality and accuracy of these estimates is bigger. In this work, we assessed the TRMM satellite precipitation products 3B42 V6, 3B42 V7, and 3B42 Real Time, and the estimates from CMORPH method (RAW) by using the observed data from Alto do Jacuí basin region. To assess these products, we have used IPWG statistics to validate the estimate products such as PC (percent correct), H (hits), FAR (false alarm ratio) performance indexes, among others. We have also assessed products performance in detecting the occurrence and non-occurrence of different rainfall events. We have employed quantitative statistics to assess mean error (ME), root-mean-square error (RMSE), correlation coefficient (r), total errors and Nash-Sutcliffe (NS) efficiency coefficient (NSE). From the results, we have tried a methodology to improve them. The PC indexes showed an average of 81.3%, and they had a similar behavior among the products, while the H index showed an average of 60%. These numbers stress that the main difficulty is to detect rainfall events. The FAR index showed an average of 8% for V6 and 9% for CMORPH; 13% for V7, and 15% for Real Time, what is considered reasonable. In the qualitative assessment, we have emphasized the CMORPH product, which showed the best analysis results. This probably happens for being a method that uses more sources of information or for exploring this information more efficiently somehow. In the predictive potential evaluation, Real Time product had the worst results (NSE). V7 resulted in a small decrease of quality when compared to V6, although it was superior in other aspects. CMORPH overcame the other products, with an NSE average of 0.45. In the quantitative assessment, we have noted that V6 and CMORPH could estimate less than 50% of the total rainfall; V7 overestimated around 11% the total rainfall, while Real Time overestimated around 25% of the total. Despite the reasonable results, all the products showed good correlation (0.73). This made us try a method to improve the detection rate. Through modified double-mass equation, we had really significant improvements, except for V7. For instance, for the detection percentage of rainfall events > 60 millimeters, the V6 was almost null 1%; 41% for Real Time; and 1.1% for CMORPH. After the application of the improved method, the detection percentage increased to 53.6%, 50.8%, and 54.8% for those products respectively. These results indicate that the satellite rainfall estimates are an alternative source of data with a great spatial and temporal potential. Thus, the products can be improved to help the hydrological monitoring, mainly in areas with low quality of precipitation data. However, there are still many things to be improved about rainfall estimates, mainly in detecting rainfall, where we have found the biggest limitations.
O continuo aumento na utilização de estimativas de precipitações utilizando dados de satélites, como fonte alternativa de dados tem aumentado com o avanço tecnológico dos dispositivos . Consequentemente aumenta a necessidade de avaliar a qualidade e a precisão dessas estimativas. Neste trabalho foram avaliados os produtos do satélite TRMM (3B42 V6, 3B42 V7 e 3B42 Real Time) e do método CMORPH (produto RAW) utilizando dados observados de precipitação da região da bacia do Alto Jacuí - RS. Para a avaliação foram utilizadas as estatísticas para validação da chuva estimada por satélite recomendadas pelo IPWG, como os índices de desempenho PC (percent correct), H (hits), FAR (false alarm ratio), CSI (critical success índex) entre outros, avaliando o desempenho dos produtos na detecção da ocorrência e na não ocorrência dos eventos. Além de estatísticas básicas, foram empregadas as quantitativas, como erro médio (EM), erro médio quadrático (EMQ), coeficiente de correlação (r), erro no volumes e coeficiente de eficiência Nash-Sutcliffe (NS). A partir dos resultados foi ainda ensaiada uma metodologia para melhora dos resultados. O índice que mede o acerto na estimativa da ocorrência (ou não) de chuvas (PC) apresentou média de 81,3%, e mostrou equilíbrio entre os produtos. Já o índice H, que indica se o satélite simplesmente acertou a chuva (e não dias sem chuva) indicou 60% de acertos, ou seja, a principal dificuldade encontrada por todos os produtos é sem dúvidas na capacidade de detecção dos eventos chuvosos. O índice que avalia o percentual de falsos alarmes (FAR), emitido pelas estimativas apresentou 8% e 9% para os produtos V6 e CMORPH respectivamente, 13% para o V7 e 15% para o Real Time sendo considerado razoável. Na avaliação qualitativa destacou-se o produto CMORPH, que obteve os melhores resultados na análise, e, provavelmente por se tratar de um método híbrido que utiliza o maior número de fontes de informações ou, de alguma forma, as explora de forma mais eficiente. Na avaliação sobre o potencial preditivo, o produto Real Time apresentou os piores resultados (Nash-Sutcliffe), ou seja, é mais vantajoso utilizar a média diária observada do que suas estimativas. O V7 resultou em um leve decréscimo da qualidade quando comparado com o V6, embora tenha se mostrado superior em outros aspectos. E novamente, o CMORPH superou os demais produtos, com coeficientes na ordem média de 0,45. Na parte quantitativa das estimativas dos produtos, notou-se grande subestimativa pelos produtos V6 e CMORPH, e superestimativa leve pelos produtos Real Time e V7, porém os produtos apresentaram boas correlações (r), resultando em uma média de 0,73. Nas comparações das médias mensais que apesar dos erros (sub ou superestimativa), os produtos se mostraram capazes de detectar a variabilidade mensal durante o ano (exceto o Real Time). Através da equação dos confrontos acumulados das séries, ao aplicar uma metodologia de correção da chuva simplificada, obtiveram-se aumentos bastante satisfatórios nos percentuais de detecções (com exceção do produto V7). Principalmente para volumes iguais ou superiores a 60 milímetros, dos quais quase nulos 1% eram detectados pelo V6, 41% pelo Real Time e apenas 1,1% pelo CMORPH, e após os ajustes aumentaram para 53,6%, 50,8 e 54,8% respectivamente. Estes resultados indicam que as estimativas de satélite são uma fonte alternativa de dados com grande qualidade temporal e espacial, fundamental para auxiliar o monitoramento hidrológico. No entanto, ainda existe muito espaço para melhoras nas estimativas de precipitação, principalmente no quesito detecção de eventos, o qual foi o principal responsável pelo decréscimo da qualidade das estimativas no estudo.
Djenidi, Brahim Fayçal. "Caractérisation moléculaire et fonctionnelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs pulmonaires humaines." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T044/document.
Повний текст джерелаToday Immunotherapy is clearly an alternative choice in the treatment of cancers. Its main objective is to enhance the cytotoxic immune response against tumor cells while preserving normal cells. We have previously demonstrated that there is an antitumor immune response in the Non-Small-Cell lung carcinoma (NSCLC) and cytotoxic T lymphocytes (CTL) contribute to NSCLC tumor regression. We further showed that the CD103 integrin interaction (oftenly expressed on tumor infiltrating lymphocytes (TIL)) with its ligand, the epithelial cell marker E-Cadherin, expressed at the surface of tumor cells, is necessary for the polarization and exocytosis of TIL cytotoxic granules and to trigger the lysis of the tumor target cells. The main purpose of my thesis project is to determine the actual role/ contribution of CD8+/CD103+ T lymphocytes (infiltrating the epithelial tumors) in the regulation of antitumor CTL response and to study the role of CD103 in the regulation of their in situ effector functions. Firstly, TIL infiltrating human NSCLC were characterized at transcriptional and phenotypic level. My results show that CD8+/CD103+ T lymphocytes have a molecular signature characteristic of memory T cells resident in tissues (MRT), with expression of CD69 receptors and CD45RO. My results also showed that this cell population co-Expresses the inhibitory receptors, PD-1 and Tim-3.In a second step, I studied the functionality of CD8+/CD103+ TIL and the role of CD103 in the regulation of anti-Tumor cytotoxic activity. My results have first indicated that CD103+ TIL are more sensitive to activation induced cell death (AICD) than TIL-CD103- and CD103+ TIL express granzyme B and CD107a after specific activation. Furthermore, CD103+ TIL are able to exert a specific cytotoxic activity against autologous tumor cells following the neutralization of PD-1- PD-L1 interaction, and that of anti-CD103 antibody inhibits this blocking function. After, I analyzed the impact of the expression of CD103 on the surface of TIL on the survival of patients with NSCLC stage 1. My results revealed that this integrin promotes the infiltration of TIL in epithelial tumor regions and a strong expression of CD103 on TIL correlates with improved patient survival. Finally, I examined the role of CD103 in this function and the antitumor immune response in vivo. My preliminary results showed a tumor growth delay of LL2 tumors transfected with E-Cadherin and CCL5 grafted in CD103-WT mice. Furthermore inhibition of growth correlates with a higher tumor infiltrating with CD8+/CD103+ T lymphocytes. These results suggest an important role of the coexpression of CCL5 and E-Cadherin by the tumor in the recruitment and retention of CTL at the tumor site. The whole work supports the role of CD103 in regulating the CD8 T cells-Mediated immune response in epithelial tumors and the usefulness of anti-PD-1 neutralizing and anti-Tim-3 for reversing the depletion of this lymphocyte population CD8+ / CD103+