Увійти

Готові списки джерел за темами / TRDMT1 / Статті в журналах

Статті в журналах з теми "TRDMT1"

Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: TRDMT1.

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 10 березня 2023

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Ознайомтеся з топ-50 статей у журналах для дослідження на тему "TRDMT1".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.

1

Yi, Xiaohua, Shuai He, Shuhui Wang, Haidong Zhao, Mingli Wu, Shirong Liu, and Xiuzhu Sun. "Detection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene <i>TRDMT1</i>." Archives Animal Breeding 64, no. 1 (April 30, 2021): 147–55. http://dx.doi.org/10.5194/aab-64-147-2021.

Повний текст джерела

Анотація:

Abstract. The tRNA modification gene in eukaryotes is relatively conservative. As an important modification gene, the TRDMT1 gene plays an important role in maintaining tRNA structural maintenance and reducing mistranslation of protein translation by methylation of specific tRNA subpopulations. Mouse and zebrafish TRDMT1 knockout experiments indicate that it may mediate growth and development through tRNA modification. However, there are no systematic reports on the function of tRNA-modified genes in livestock. In this study, Qinchuan cattle DNA pool sequencing technology was used. A G>C mutation in the −1223 bp position upstream of the TRDMT1 translation initiator codon was found. At this locus, the dual-luciferase assay indicated that different genotypes cause differences in transcriptional activity (P<0.05). Our experiment detected a natural genetic variation of a tRNA modification gene TRDMT1, which may provide potential natural molecular materials for the study of tRNA modification.

Стилі APA, Harvard, Vancouver, ISO та ін.

2

Filip, Kamila, Anna Lewińska, Jagoda Adamczyk-Grochala, Antonella Marino Gammazza, Francesco Cappello, Marianna Lauricella та Maciej Wnuk. "5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells". Cells 11, № 7 (4 квітня 2022): 1213. http://dx.doi.org/10.3390/cells11071213.

Повний текст джерела

Анотація:

5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellular stress responses such as apoptosis, autophagy, and senescence. The action of 5-azaC is complex and can be modulated by dose, time of treatment, and co-administration with oxidants. Insulinoma is a rare pancreatic neuroendocrine tumor with limited chemotherapeutic options. In the present study, two cellular models of insulinoma were considered, namely NIT-1 and β-TC-6 mouse cells, to evaluate the effects of 5-azaC post-treatment during hydrogen peroxide-induced oxidative stress. 5-azaC attenuated the development of oxidant-induced senescent phenotype in both cell lines. No pro-apoptotic action of 5-azaC was observed in cells treated with the oxidant. On the contrary, 5-azaC stimulated an autophagic response, as demonstrated by the increase in phosphorylated eIF2α and elevated pools of autophagic marker LC3B in oxidant-treated β-TC-6 cells. Notably, autophagy resulted in increased necrotic cell death in β-TC-6 cells with higher levels of nitric oxide compared to less affected NIT-1 cells. In addition, 5-azaC increased levels of RNA methyltransferase Trdmt1, but lowered 5-mC and m6A levels, suggesting Trdmt1 inhibition. We postulate that the 5-azaC anticancer action may be potentiated during oxidative stress conditions that can be used to sensitize cancer cells, at least insulinoma cells, with limited drug responsiveness.

Стилі APA, Harvard, Vancouver, ISO та ін.

3

Ghanbarian, Hossein, Nicole Wagner, Beatrice Polo, Delphine Baudouy, Jafar Kiani, Jean-François Michiels, François Cuzin, Minoo Rassoulzadegan, and Kay-Dietrich Wagner. "Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth." PLOS ONE 11, no. 6 (June 6, 2016): e0156953. http://dx.doi.org/10.1371/journal.pone.0156953.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

4

Govindaraju, Gayathri, CA Jabeena, Devadathan Valiyamangalath Sethumadhavan, Nivethika Rajaram, and Arumugam Rajavelu. "DNA methyltransferase homologue TRDMT1 in Plasmodium falciparum specifically methylates endogenous aspartic acid tRNA." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860, no. 10 (October 2017): 1047–57. http://dx.doi.org/10.1016/j.bbagrm.2017.08.003.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

5

Sha, Chunli, Lu Chen, Li Lin, Taoqiong Li, Hong Wei, Meiling Yang, Wujiang Gao, et al. "TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure." Aging 13, no. 11 (June 8, 2021): 15193–213. http://dx.doi.org/10.18632/aging.203080.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

6

Betlej, Gabriela, Tomasz Ząbek, Anna Lewińska, Dominika Błoniarz, Iwona Rzeszutek, and Maciej Wnuk. "RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines." Journal of Bone Oncology 36 (October 2022): 100448. http://dx.doi.org/10.1016/j.jbo.2022.100448.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

7

Bloniarz, Dominika, Jagoda Adamczyk-Grochala, Anna Lewinska, and Maciej Wnuk. "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence." Aging 13, no. 12 (June 17, 2021): 15833–74. http://dx.doi.org/10.18632/aging.203203.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

8

Wnuk, Maciej, Piotr Slipek, Mateusz Dziedzic, and Anna Lewinska. "The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections." International Journal of Molecular Sciences 21, no. 21 (October 31, 2020): 8176. http://dx.doi.org/10.3390/ijms21218176.

Повний текст джерела

Анотація:

Eukaryotic 5-methylcytosine RNA methyltransferases catalyze the transfer of a methyl group to the fifth carbon of a cytosine base in RNA sequences to produce 5-methylcytosine (m5C). m5C RNA methyltransferases play a crucial role in the maintenance of functionality and stability of RNA. Viruses have developed a number of strategies to suppress host innate immunity and ensure efficient transcription and translation for the replication of new virions. One such viral strategy is to use host m5C RNA methyltransferases to modify viral RNA and thus to affect antiviral host responses. Here, we summarize the latest findings concerning the roles of m5C RNA methyltransferases, namely, NOL1/NOP2/SUN domain (NSUN) proteins and DNA methyltransferase 2/tRNA methyltransferase 1 (DNMT2/TRDMT1) during viral infections. Moreover, the use of m5C RNA methyltransferase inhibitors as an antiviral therapy is discussed.

Стилі APA, Harvard, Vancouver, ISO та ін.

9

Xue, Songlei, Hui Xu, Zhen Sun, Hui Shen, Shihao Chen, Juan Ouyang, Qiqi Zhou, Xuming Hu, and Hengmi Cui. "Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration." Biochemical and Biophysical Research Communications 520, no. 1 (November 2019): 60–66. http://dx.doi.org/10.1016/j.bbrc.2019.09.098.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

10

Li, Zhengguang, Xiaolong Qi, Xu Zhang, Lei Yu, Lijuan Gao, Weining Kong, Wei Chen та ін. "TRDMT1 exhibited protective effects against LPS ‐induced inflammation in rats through TLR4‐NF‐κB / MAPK‐TNF ‐α pathway". Animal Models and Experimental Medicine 5, № 2 (квітень 2022): 172–82. http://dx.doi.org/10.1002/ame2.12221.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

11

Halby, Ludovic, Nils Marechal, Dany Pechalrieu, Vincent Cura, Don-Marc Franchini, Céline Faux, Fréderic Alby, et al. "Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1748 (April 23, 2018): 20170072. http://dx.doi.org/10.1098/rstb.2017.0072.

Повний текст джерела

Анотація:

DNA, RNA and histone methylation is implicated in various human diseases such as cancer or viral infections, playing a major role in cell process regulation, especially in modulation of gene expression. Here we developed a convergent synthetic pathway starting from a protected bromomethylcytosine derivative to synthesize transition state analogues of the DNA methyltransferases. This approach led to seven 5-methylcytosine-adenosine compounds that were, surprisingly, inactive against hDNMT1, hDNMT3Acat, TRDMT1 and other RNA human and viral methyltransferases. Interestingly, compound 4 and its derivative 2 showed an inhibitory activity against PRMT4 in the micromolar range. Crystal structures showed that compound 4 binds to the PRMT4 active site, displacing strongly the S -adenosyl- l -methionine cofactor, occupying its binding site, and interacting with the arginine substrate site through the cytosine moiety that probes the space filled by a substrate peptide methylation intermediate. Furthermore, the binding of the compounds induces important structural switches. These findings open new routes for the conception of new potent PRMT4 inhibitors based on the 5-methylcytosine-adenosine scaffold. This article is part of a discussion meeting issue ‘Frontiers in epigenetic chemical biology’.

Стилі APA, Harvard, Vancouver, ISO та ін.

12

Betlej, Gabriela, Anna Lewińska, Jagoda Adamczyk-Grochala, Dominika Błoniarz, Iwona Rzeszutek, and Maciej Wnuk. "Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells." Toxicology in Vitro 80 (April 2022): 105323. http://dx.doi.org/10.1016/j.tiv.2022.105323.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

13

Pena Bello, Camilo P., Isadora M. Batalha, Evandro C. Archilia, Katarina Wulstein, and Luis F. F. Schütz. "PSIII-3 Late-Breaking: Diisobutyl Phthalate (DIBP) at Low Doses Alters Gene Expression of Epigenetic Regulators in Bovine Granulosa Cells." Journal of Animal Science 100, Supplement_4 (October 22, 2022): 34–35. http://dx.doi.org/10.1093/jas/skac313.049.

Повний текст джерела

Анотація:

Abstract Phthalates are ubiquitous environmental contaminants and impact reproduction and epigenetic mechanisms. The use of diisobutyl phthalate (DIBP) has increased in the last decade. However, studies about DIBP's effects on female reproductive physiology are limited. Methylation of DNA and RNA are epigenetic processes that regulate gene expression, cell biology, and reproductive functions. How DIBP exposure regulates these epigenetic mechanisms in ovarian follicular cells remains to be unveiled. We hypothesize that DIBP at low doses alters the expression of RNA and DNA methylation regulators in bovine granulosa cells (GC). Bovine GC was isolated from small antral follicles (1-5 mm on surface diameter) from ovaries obtained at a slaughterhouse. Cells were cultured in vitro until reaching an average 70% confluence and treated with DIBP at levels detected in human blood (0 ng/mL, 1 ng/mL, 10 ng/mL, 100 ng/mL) combined with hormones that regulate ovarian folliculogenesis: FSH or FSH+IGF1. Cells were cultured for 24h for total RNA isolation (n = 5 pools) or for 48h for cell counting (n=5 pools). Relative mRNA abundance of RNA N6 methyladenine (m6A) methylation machinery (m6A writers: METTL3, METTL14; m6A erasers: ALKBH5, FTO), RNA 5-methylcytosine (m5C) methylation regulators (NSUN2, TRDMT1), and DNA methylation players (DNA methyltransferases: DNMT1, DNMT3A, DNMT3B; DNA demethylases: TET1, TET2, TET3) was determined via qPCR using 18S as housekeeping gene and expressed as 2-ΔΔCt. Cell proliferation was analyzed by cell counting using a MUSE cell analyzer. Data were analyzed via one-way ANOVA with GLM procedures of SAS for Windows. Normality was tested using Shapiro-Wilk test procedures and data considered not normal were transformed to log2 (Y + 0.6). Data sets that showed non-gaussian distribution after log-transformation was analyzed via the Kruskal-Wallis test using GraphPad Prism 9.2.0. Cell proliferation was not affected by DIBP treatments in combination with FSH or with FSH+IGF1. In GC treated with FSH in combination with DIBP, there was no significant effect on relative mRNA abundance of RNA or DNA methylation players. In combination with FSH+IGF1, GC treated with DIBP had lower (P < 0.05) METTL14 relative mRNA abundance at 1 ng/mL and 10 ng/mL than at 0 ng/mL and 100 ng/mL. TRDMT1 relative mRNA abundance was lower (P < 0.05) in the DIBP group at 10 ng/mL in comparison to groups 0 ng/mL and 1 ng/mL, but no 100 ng/mL. In addition, there was no significant effect on the relative mRNA abundance of DNA methylation regulators. In summary, GC treated with FSH+IGF1 and DIBP at low doses alters the gene expression of RNA methylation players in m6A and m5C RNA modifications in a non-monotonic dose-response, but does not alter mRNA abundance of DNA methylation regulators.

Стилі APA, Harvard, Vancouver, ISO та ін.

14

Franke, Barbara, Sita H. H. M. Vermeulen, Regine P. M. Steegers-Theunissen, Marieke J. Coenen, Mascha M. V. A. P. Schijvenaars, Hans Scheffer, Martin den Heijer, and Henk J. Blom. "An association study of 45 folate-related genes in spina bifida: Involvement ofcubilin(CUBN) andtRNA aspartic acid methyltransferase 1(TRDMT1)." Birth Defects Research Part A: Clinical and Molecular Teratology 85, no. 3 (March 2009): 216–26. http://dx.doi.org/10.1002/bdra.20556.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

15

Babič, Matej. "Analiza topografije robotsko lasersko kaljenih materialov s pomočjo strojnega učenja." Anali PAZU 10, no. 1-2 (June 9, 2022): 24–27. http://dx.doi.org/10.18690/analipazu.10.1-2.24-27.2020.

Повний текст джерела

Анотація:

Laserska obdelava materialov, vključno s toplotno obdelavo, temelji na uporabi laserskega sevanja, ki vam omogoča, da na zelo majhni površini ustvarite visoke gostote toplotnega polja, potrebne za intenzivno segrevanje ali taljenje. V članku je predstavljen vpliv parametra robotske laserske celice na topografijo materialov. S pomočjo metod strojnega učenja je predstavljeno, kako parametri robotske laserske celice vplivajo na trdoto in hrapavost kaljenega materiala, ter kakšna je povezava med trdoto in hrapavostjo.

Стилі APA, Harvard, Vancouver, ISO та ін.

16

Peng, Baochai, Dong Ren, Cheng Zheng, and Anxiang Lu. "TRDet: Two-Stage Rotated Detection of Rural Buildings in Remote Sensing Images." Remote Sensing 14, no. 3 (January 22, 2022): 522. http://dx.doi.org/10.3390/rs14030522.

Повний текст джерела

Анотація:

Fast and accurate acquisition of the outline of rural buildings on remote sensing images is an efficient method to monitor illegal rural buildings. The traditional object detection method produces useless background information when detecting rural buildings; the semantic segmentation method cannot accurately segment the contours between buildings; the instance segmentation method cannot obtain regular building contours. The rotated object detection methods can effectively solve the problem that the traditional artificial intelligence method cannot accurately extract the outline of buildings. However, the rotated object detection methods are easy to lose location information of small objects in advanced feature maps and are sensitive to noise. To resolve these problems, this paper proposes a two-stage rotated object detection network for rural buildings (TRDet) by using a deep feature fusion network (DFF-Net) and a pixel attention module (PAM). Specifically, TRDet first fuses low-level location and high-level semantic information through the DFF-Net and then reduces the interference of noise information to the network through the PAM. The experimental results show that the mean average precession (mAP), precision, recall rate, and F1 score of the proposed TRDet are 83.57%, 91.11%, 86.5%, and 88.74%, respectively, which outperform the R2CNN model by 15%, 15.54%, 4.01%, and 9.87%. The results demonstrate that the TRDet can achieve better detection in small rural buildings and dense rural buildings.

Стилі APA, Harvard, Vancouver, ISO та ін.

17

Zhao, Lijuan, Richard L. Frock, Zhou Du, Jiazhi Hu, Liang Chen, Michael S. Krangel, and Frederick W. Alt. "Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development." Journal of Experimental Medicine 213, no. 9 (August 15, 2016): 1921–36. http://dx.doi.org/10.1084/jem.20160670.

Повний текст джерела

Анотація:

T cell antigen receptor δ (Tcrd) variable region exons are assembled by RAG-initiated V(D)J recombination events in developing γδ thymocytes. Here, we use linear amplification–mediated high-throughput genome-wide translocation sequencing (LAM-HTGTS) to map hundreds of thousands of RAG-initiated Tcrd D segment (Trdd1 and Trdd2) rearrangements in CD4−CD8− double-negative thymocyte progenitors differentiated in vitro from bone marrow–derived hematopoietic stem cells. We find that Trdd2 joins directly to Trdv, Trdd1, and Trdj segments, whereas Trdd1 joining is ordered with joining to Trdd2, a prerequisite for further rearrangement. We also find frequent, previously unappreciated, Trdd1 and Trdd2 rearrangements that inactivate Tcrd, including sequential rearrangements from V(D)J recombination signal sequence fusions. Moreover, we find dozens of RAG off-target sequences that are generated via RAG tracking both upstream and downstream from the Trdd2 recombination center across the Tcrd loop domain that is bounded by the upstream INT1-2 and downstream TEA elements. Disruption of the upstream INT1-2 boundary of this loop domain allows spreading of RAG on- and off-target activity to the proximal Trdv domain and, correspondingly, shifts the Tcrd V(D)J recombination landscape by leading to predominant V(D)J joining to a proximal Trdv3 pseudogene that lies just upstream of the normal boundary.

Стилі APA, Harvard, Vancouver, ISO та ін.

18

Derganc, Aleksandra. "Za kakšno sedanjost gre v izjavi Še pogleda me ne?" Linguistica 61, no. 2 (December 30, 2021): 43–47. http://dx.doi.org/10.4312/linguistica.61.2.43-47.

Повний текст джерела

Анотація:

V prispevku se razpravlja o tem, ali bi slovenski stavek Še pogleda me ne lahko služil kot zgled za to, da je mogoče v slovenščini aktualno sedanjost izraziti z dovršnim sedanjikom. Čeprav ni mogoče trditi, da je vidsko obnašanje v vseh slovanskih jezikih enotno, pa se zdi, da stara Miklošičeva trditev, da je odgovor na vprašanje Kaj počneš? v slovanskih jezikih praviloma nedovršni sedanjik, še vedno drži. Dovršni sedanjik ima v slovenščini vrsto pomenov, vendar nima pomena aktualne sedanjosti. Kot navajata slovnica avtorjev Bajec, Kolarič, Rupel in Toporišičeva slovnica, imajo nekateri pomeni dovršnega sedanjika modalno komponento sem pripravljen, sem sposoben, nameravam narediti. Modalno komponento ima verjetno tudi ti. prasens effectivum oz. performativna raba tipa obljubim, prisežem. Mogoče je torej trditi, da ima dovršni sedanjik v Še pogleda me ne modalni pomen – ‘še pogledati me noče’, za kar najdemo paralele tudi v drugih slovanskih jezikih, med drugim tudi v starem novgorodskem dialektu (po Zaliznjaku prezens naprasnogo ožidanija).

Стилі APA, Harvard, Vancouver, ISO та ін.

19

Lima, Alisson Padilha de, Fabrício Bruno Cardoso, and Heron Beresford. "O valor de um programa ludomotor para a melhoria da velocidade de reação de crianças." ConScientiae Saúde 12, no. 3 (October 15, 2013): 398–404. http://dx.doi.org/10.5585/conssaude.v12n3.4153.

Повний текст джерела

Анотація:

Objetivo: Avaliar a eficácia de um programa ludomotor de soltar pipas, voltado para desenvolver a velocidade de reação. Método: Este estudo foi desenvolvido utilizando-se os testes de reação motora (TRM), composto de três provas específicas: Tempo Reação Simples (TRS), Tempo de Reação com Discriminação (TRD) e Tempo de Reação com Discriminação para Tarefa Complexa (TRDTC). Resultados: Após 65 sessões do programa ludomotor, com duração de 45 minutos cada uma, mostrou-se, em relação ao TRS, TRD e TRDTC, uma significância estatística, em que foi identificada a importância da intervenção proposta. Conclusão: Verificou-se que a intervenção desenvolvida neste trabalho refinou as habilidades perceptivo-motoras dos alunos, o que se refletiu no desenvolvimento da coordenação visomotora.

Стилі APA, Harvard, Vancouver, ISO та ін.

20

T.S., Kavya, and Sunil Jacob. "Energy Efficient TRDMA over Multipath Channels." Communications on Applied Electronics 2, no. 7 (August 25, 2015): 6–11. http://dx.doi.org/10.5120/cae2015651797.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

21

Louderback, Eric R., and Olena Antonaccio. "Exploring Cognitive Decision-making Processes, Computer-focused Cyber Deviance Involvement and Victimization." Journal of Research in Crime and Delinquency 54, no. 5 (February 27, 2017): 639–79. http://dx.doi.org/10.1177/0022427817693036.

Повний текст джерела

Анотація:

Objectives: Investigate the relationship between thoughtfully reflective decision-making (TRDM) and computer-focused cyber deviance involvement and computer-focused cybercrime victimization. Method: Survey data collected from samples of 1,039 employees and 418 students at a large private university were analyzed using ordinary least squares and negative binomial regression to test the effects of TRDM on computer-focused cyber deviance involvement and victimization. Results: TRDM reduces computer-focused cyber deviance involvement and computer-focused cybercrime victimization across measures and samples. The sensitivity analyses also indicated that TRDM is a more robust predictor of cyber deviance involvement than victimization. The results from moderation analyses showed that, whereas protective effects of TRDM are invariant across genders, they are less salient among older employees for the scenario-based measure of cybercrime victimization. Conclusions: Individual-level cognitive decision-making processes are important in predicting computer-focused cyber deviance involvement and victimization. These results can inform the development of targeted institutional and criminal justice policies aimed at reducing computer-focused cybercrime.

Стилі APA, Harvard, Vancouver, ISO та ін.

22

Zheng, Xin Wei, Zhi Yu Wang, Zi Gang Chen, Yu Sun, Bing Han, and Xue You Wen. "Feasibility for the Application of the Temperature Difference Computing Method Based on the Simplified Solution of the Radial Temperature for a Boiler Steam Drum Wall to a Supercharged Boiler." Advanced Materials Research 383-390 (November 2011): 6383–90. http://dx.doi.org/10.4028/www.scientific.net/amr.383-390.6383.

Повний текст джерела

Анотація:

The radial temperature difference calculation of a steam drum wall is an important step in the process of calculating the low-cycle fatigue lifetime of a steam drum. So the German Standard TRD301 recommended a temperature difference computing method based on the simplified solution for the radial temperature of a steam drum wall. In order to validate the feasibility for the application of this computing method to solving the same problem of a supercharged boiler, on the basis of the reasonable simplifications to the unstable heat conduction problem across a steam drum wall, its heat-conduction equations and definite conditions were determined, then the analytical solution for the radial temperature of a steam drum wall, together with its approximate and simplified solutions, is derived. The running example of one super-charged boiler was calculated and analyzed by use of the radial temperature difference computing methods based on the approximate and simplified solutions respectively. The com-puted results show that the German Standard computing method of TRD301 has great limitations in the same problem calculation of a supercharged boiler, and it can’t apply to the researches on the same problem and its relevant problems of a supercharged boiler as a universal computing method.

Стилі APA, Harvard, Vancouver, ISO та ін.

23

Rudolf, Rebeka, Tilen Ravlan, Gorazd Lojen, Peter Majerič, and Egidij Hudrap. "Prikaz poteka razvoja naprednega orodnega jekla za najzahtevnejše aplikacije v industriji nožev." Anali PAZU 10, no. 1-2 (June 9, 2022): 36–40. http://dx.doi.org/10.18690/analipazu.10.1-2.36-40.2020.

Повний текст джерела

Анотація:

V prispevku predstavljamo izhodišča in smernice poteka razvoja naprednega orodnega jekla za najzahtevnejše aplikacije v industriji nožev, ki se izvaja v podjetju SIJ Ravne Systems v povezavi z Univerzo v Mariboru Fakulteto za strojništvo. Razvoj je na eni strani povezan z identifikacijo ključnih lastnosti orodnega jekla, ki predstavljajo konkurenčno prednost v primerjavi z ostalimi konvencionalnimi jekli in to so: žilavost, trdota, trdnost in rezilna sposobnost. Po drugi strani pa razvoj predstavlja tudi vpeljavo ustrezne tehnologije izdelave in naknadne toplotne oziroma mehanske obdelave orodnega jekla, kar omogoča doseganje ključnih lastnosti izdelka – nožev.

Стилі APA, Harvard, Vancouver, ISO та ін.

24

Švajncer, Marija. "Demaskirajoče tendence." Ars & Humanitas 12, no. 2 (December 27, 2018): 340–45. http://dx.doi.org/10.4312/ah.12.2.340-345.

Повний текст джерела

Анотація:

Cvetka Hedžet Tóth, ena vodilnih in nadvse ustvarjalnih slovenskih filozofinj, je pri Znanstveni založbi Filozofske fakultete v Ljubljani prav v času svojega življenjskega jubileja objavila novo, več kot štiristo strani dolgo knjigo z naslovom Demaskirajoče tendence (2018). Kljub obsežnosti, tehtnosti, poglobljenosti in napredni angažiranosti ni primerno trditi, da je knjiga filozofinjino življenjsko delo, saj bo zagotovo napisala še veliko prav tako kakovostnih in zanimivih knjig, po kakršnih jo pozna slovenska javnost ter njeni študenti in študentke, ki se jim na Filozofski fakulteti v Ljubljani vrsto let razdaja s svojim bogatim znanjem in humanostjo.

Стилі APA, Harvard, Vancouver, ISO та ін.

25

Švajncer, Marija. "Demaskirajoče tendence." Ars & Humanitas 12, no. 2 (December 27, 2018): 340–45. http://dx.doi.org/10.4312/ars.12.2.340-345.

Повний текст джерела

Анотація:

Cvetka Hedžet Tóth, ena vodilnih in nadvse ustvarjalnih slovenskih filozofinj, je pri Znanstveni založbi Filozofske fakultete v Ljubljani prav v času svojega življenjskega jubileja objavila novo, več kot štiristo strani dolgo knjigo z naslovom Demaskirajoče tendence (2018). Kljub obsežnosti, tehtnosti, poglobljenosti in napredni angažiranosti ni primerno trditi, da je knjiga filozofinjino življenjsko delo, saj bo zagotovo napisala še veliko prav tako kakovostnih in zanimivih knjig, po kakršnih jo pozna slovenska javnost ter njeni študenti in študentke, ki se jim na Filozofski fakulteti v Ljubljani vrsto let razdaja s svojim bogatim znanjem in humanostjo.

Стилі APA, Harvard, Vancouver, ISO та ін.

26

Starc, Iva. "Odnos študentov Univerze v Novem mestu do trajnostnih izdelkov." Revija za ekonomske in poslovne vede 9, no. 2 (December 15, 2022): 39–53. http://dx.doi.org/10.55707/eb.v9i2.117.

Повний текст джерела

Анотація:

Potrošniki v zadnjih nekaj letih vedno pogosteje od podjetij zahtevajo, da trajnostno poslujejo in proizvajajo trajnostne izdelke. Zato lahko na trgu vedno pogosteje najdemo trajnostne izdelke. Namen raziskave je bil ugotoviti, kakšen odnos imajo študenti Univerze v Novem mestu do trajnostnih izdelkov. Raziskava je bila izvedena novembra in decembra 2021, uporabili smo tehniko anketiranja. Rezultati so pokazali, da so študentom Univerze v Novem mestu trajnostni izdelki všeč. Razlik med spoloma in starostnimi skupinami v pogostosti poseganja po trajnostnih izdelkih ni. Prav tako ne moremo trditi, da študenti Univerze v Novem mestu čutijo pritisk družbe k kupovanju trajnostnih izdelkov.

Стилі APA, Harvard, Vancouver, ISO та ін.

27

Touvrey, C., L. G. Cowell, A. E. Lieberman, P. N. Marche, E. Jouvin-Marche, and S. M. Candéias. "Reassignment of the murine 3′TRDD1 recombination signal sequence." Immunogenetics 58, no. 11 (October 5, 2006): 895–903. http://dx.doi.org/10.1007/s00251-006-0150-1.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

28

Lisiecki, A. "Mechanisms of hardness increase for composite surface layers during laser gas nitriding of the Ti6Al4V alloy." Materiali in tehnologije 51, no. 4 (July 27, 2017): 577–83. http://dx.doi.org/10.17222/mit.2016.106.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

29

Han, Feng, and K. J. Ray Liu. "A Multiuser TRDMA Uplink System with 2D Parallel Interference Cancellation." IEEE Transactions on Communications 62, no. 3 (March 2014): 1011–22. http://dx.doi.org/10.1109/tcomm.2014.013114.130632.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

30

Paternoster, Alenka. "Slovenska imena bitij in zemljepisna imena v turističnih vodnikih in virih informativne narave, prevedenih v francoščino." Journal for Foreign Languages 3, no. 1-2 (December 31, 2011): 7–22. http://dx.doi.org/10.4312/vestnik.3.7-22.

Повний текст джерела

Анотація:

V prispevku smo z lastnoimenskega stališča analizirali francoske prevode slovenskih turističnih brošur, ki sta jih izdali Slovenska turistična organizacija ali Vlada Republike Slovenije, Pisarna za odnose z javnostjo in mediji.Posvetili smo se imenom bitij (skupina je pričakovano manj obsežna) in zlasti zemljepisnim imenom. Medtem ko pri prevajanju imen bitij nismo zaznali večjih zagat, ne moremo trditi enako za zemljepisna imena. Podobno kot imena bitij tudi enobesedna zemljepisna poimenovanja ne povzročajo večjih zagat. Te se pojavljajo pri večbesednih ze mljepisnih poimenovanjih.Ker gre pri turističnih brošurah za pomemben vidik predstavitve države navzven, bi pričakovali, da bodo dobili prevajalci podrobnejše smernice za prevajanje lastnih imen. Upamo, da v pričujočem prispevku na dovolj jasen način osvetlimo prevajalske zagate in s tem koga spodbudimo k nastanku omenjenih smernic oziroma priporočil.

Стилі APA, Harvard, Vancouver, ISO та ін.

31

Guštin, A. Z., B. Žužek, B. Podgornik, and V. Kevorkijan. "The uncertainty of hardness measurements related to the measurement method, surface preparation and range of the measurements." Materiali in tehnologije 53, no. 6 (December 19, 2019): 897–904. http://dx.doi.org/10.17222/mit.2019.098.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

32

Sedlaček, M., B. Šetina Batič, D. Česnik, and B. Podgornik. "Influence of the substrate hardness and fracture toughness on the dynamic wear properties of coated tool steels." Materiali in tehnologije 53, no. 4 (July 23, 2019): 565–74. http://dx.doi.org/10.17222/mit.2018.242.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

33

Guštin, A., M. Sedlaček, B. Žužek, B. Podgornik, and V. Kevorkijan. "Analysis of the surface-preparation effect on the hardness-measurement uncertainty of aluminium alloys." Materiali in tehnologije 54, no. 6 (December 15, 2020): 845–52. http://dx.doi.org/10.17222/mit.2020.008.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

34

Yu, Ya Jun, and Xiao Geng Tian. "Fractional Order Generalized Electro-Magneto-Thermo-Elasticity with Magnetic Monopoles and Geometrical Nonlinearity." Applied Mechanics and Materials 273 (January 2013): 162–66. http://dx.doi.org/10.4028/www.scientific.net/amm.273.162.

Повний текст джерела

Анотація:

Recently, Youssef developed the fractional order generalized thermoelasticity (FOGTE) in the context of extended thermoelasticity (ETE). In this work, we extended the concept of fractional calculus into the temperature rate dependent thermoelasticity (TRDTE) and introduced the unified form of the two cases. Upon introducing the electromagnetic field with magnetic monopoles and considering the geometrical nonlinearity, we proposed a fractional order generalized electro-magneto- thermo-elasticity (FOGEMm-poleTEg-non) with magnetic monopoles (m-pole) and geometrical nonlinearity (g-non). To deal with multi-physics problems using numerical methods, we obtained a generalized variational theorem by using the semi-inverse method.

Стилі APA, Harvard, Vancouver, ISO та ін.

35

Hertelé, Stijn, Jonas Bally, Nenad Gubeljak, Primož Štefane, Patricia Verleysen, and Wim De Waele. "Characterization of heterogeneous arc welds through miniature tensile testing and Vickers-hardness mapping." Materiali in tehnologije 50, no. 4 (August 12, 2016): 571–74. http://dx.doi.org/10.17222/mit.2015.157.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

36

Özdemir Öge, T., M. Öge, V. Murat Yilmaz, and F. Banu Özdemir. "Effect of B4C addition on the microstructure, hardness and dry-sliding-wear performance of AZ91 composites produced with hot pressing." materiali in tehnologije 53, no. 3 (June 12, 2019): 433–40. http://dx.doi.org/10.17222/mit.2018.127.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

37

Noor, Ahmad Shukri Mohd, Tutut Herawan, and Mustafa Mat Deris. "Neighbor-Replica Distribution Technique Model for Availability Prediction in Distributed Interdependent Environment." International Journal of Cloud Applications and Computing 2, no. 3 (July 2012): 98–109. http://dx.doi.org/10.4018/ijcac.2012070105.

Повний текст джерела

Анотація:

High availability is important for large scale distributed systems. Replication provides effective ways to enhance performance, high availability and fault tolerance in distributed systems. An efficient and effective replication technique is the key to improve the availability performance. Data and processes can be replicated for failures recovery. There are currently projects successfully implemented in two-replica distribution technique (TRDT) or primary–backup technique. However, these projects have their weaknesses of increasing cost overhead and inherit irrecoverable scenarios from TRDT such as double faults when both copies of replicated components are damaged. The authors propose the Neighbor Replica Distributed Technique (NRDT) availability prediction model. Focusing on improving high availability in which it predicts future expectation of interdependent server’s availability in a distributed online system over an extended period of time. The results and discussion are explored further in the article.

Стилі APA, Harvard, Vancouver, ISO та ін.

38

Škvor Jernejčič, Brina. "O kovinah v Heziodovih pesnitvah Teogonija in Dela in dnevi: kratek razmislek." Keria: Studia Latina et Graeca 13, no. 2 (December 24, 2011): 31. http://dx.doi.org/10.4312/keria.13.2.31-43.

Повний текст джерела

Анотація:

Prispevek skuša ovrednotiti vlogo kovin v Heziodovih pesnitvah Teogonija ter Dela in dnevi. Zlato je pri Heziodu božanska kovina – le bogovi ga nosijo, zlati, najboljši izmed rodov, je prav tako bogovom najbližji. V obeh pesnitvah redko omenjeno srebro je slabše od zlata in ni več atribut bogov. S srebrom Heziod opisuje vrtince rek, visoke stebre v podzemlju, nimfe. Tako kot je srebro manj vredno od zlata, je tudi srebrni rod manj vreden od zlatega. Bronu, prvi zlitini, pripiše pesnik lastnosti trdote in moči, iz njega sta izdelana orodje in orožje, s katerim bronasti rod bojuje vojne. Železo se v pesnitvah pojavi kot kovina iz katere sta izdelana orodje in orožje, železni rod, najslabšega izmed vseh rodov, pestita žalost in težko delo. Kljub temu, da je izdelava železnih predmetov spodbudila velik tehnološki napredek, pomeni ta kovina pesniku sinonim za trdo delo, napore in bedo – skratka popolno nasprotje zlatemu, tj. božanskemu.

Стилі APA, Harvard, Vancouver, ISO та ін.

39

Cergol, Jadranka. "Anton Dokler in Matej Hriberšek: Šolski grško-slovenski slovar." Keria: Studia Latina et Graeca 17, no. 2 (December 30, 2015): 144. http://dx.doi.org/10.4312/keria.17.2.144-146.

Повний текст джерела

Анотація:

Če si izposodim besede Janeza (Ivana) Samse v članku iz leta 1916, objavljenem v reviji Dom in svet in namenjenem predstavitvi komaj iz danega grško-slovenskega slovarja, bi si upala trditi, da je grško-slovenski slovar tako redek podvig, »kakor cvetje bajne aloe, ki se pojavi menda vsakih sto let«. Vsi tisti, ki smo staro grščino začeli študirati že v gimnazijskih letih, smo imeli za nepogrešljivega sopotnika tudi prvi in edini grško-slovenski slovar, ki smo ga po domače imenovali kar »Dokler« in ki je izšel daljnega leta 1915. Dijaki, ki smo prevajali grška besedila v gimnaziji, smo se večkrat tudi posmehovali že zastarelemu slovenskemu jeziku, ki smo ga zasledili v slovarju. Naš stari »Dokler« pa je ostajal kot steber sredi dolgih popoldnevov, ki smo jih preživeli ob grških besedilih, in bil za vse nas pravi sopotnik pri odkrivanju in razčlenjevanju dolgih grških stavkov ter spoznavanju nepogrešljivih zakladov grške modrosti.

Стилі APA, Harvard, Vancouver, ISO та ін.

40

Santra, S., A. Lahiri, and N. C. Das. "Effect of Rotation in an Orthotropic Elastic Slab." International Journal of Applied Mechanics and Engineering 22, no. 1 (February 1, 2017): 163–74. http://dx.doi.org/10.1515/ijame-2017-0010.

Повний текст джерела

Анотація:

Abstract The fundamental equations of the two dimensional generalized thermoelasticity (L-S model) with one relaxation time parameter in orthotropic elastic slab has been considered under effect of rotation. The normal mode analysis is used to the basic equations of motion and heat conduction equation. Finally, the resulting equations are written in the form of a vector-matrix differential equation which is then solved by the eigenvalue approach. The field variables in the space time domain are obtained numerically. The results corresponding to the cases of conventional thermoelasticity CTE), extended thermoelasticity (ETE) and temperature rate dependent thermoelasticity (TRDTE) are compared by means of graphs.

Стилі APA, Harvard, Vancouver, ISO та ін.

41

Houston, Kelly, Arnis Druka, Nicky Bonar, Malcolm Macaulay, Udda Lundqvist, Jerome Franckowiak, Michele Morgante, Nils Stein, and Robbie Waugh. "Analysis of the barley bract suppression gene Trd1." Theoretical and Applied Genetics 125, no. 1 (March 7, 2012): 33–45. http://dx.doi.org/10.1007/s00122-012-1814-x.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

42

Maranci, Christina. "The Architect Trdat: Building Practices and Cross-Cultural Exchange in Byzantium and Armenia." Journal of the Society of Architectural Historians 62, no. 3 (September 2003): 294–305. http://dx.doi.org/10.2307/3592516.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

43

Barši, Izidor. "Univerzalna zgodovina spomina." Ars & Humanitas 12, no. 2 (December 27, 2018): 41–55. http://dx.doi.org/10.4312/ah.12.2.41-55.

Повний текст джерела

Анотація:

V knjigi Anti-Ojdip Gilles Deleuze in Felix Guattari razločujeta med dvema vrstama spomina: besednim ali aliansnim ter biofiliacijskim. V njuni koncepciji družbe primata nima menjava, temveč dolg: temeljno družbeno razmerje je torej razmerje med upnikom in dolžnikom. Nujni pogoj tega razmerja je spomin, ki zagotavlja, da dolg ni pozabljen. Vendar ta spomin ni samoumeven, ampak ga je bilo treba človeku šele narediti. To »predzgodovinsko delo človeka« Deleuze in Guattari interpretirata kot osrednji napor »primitivnega sociusa«, ki sestoji iz vseh krutih tehnik vpisovanja v telo, kar imenujeta »sistem krutosti«. Avtorja se opreta na Nietzschejevo Genealogijo morale in trdita, da se besedni spomin vzpostavi na podlagi »aktivne sposobnosti pozabe« in s »potlačitvijo biološkega spomina«. Če je sredstvo vzpostavitve besednega spomina sistem krutosti in njen agens aliansa oziroma primitivni socius sam, kaj točno je potlačitev in kaj je tisto, kar je potlačeno? Biofiliacijski spomin imenujeta tudi »intenzivni spomin filiacije«, »spomin učinkov« ter »biokozmični spomin«, vendar v knjigi njegovega pojmovanja ne razvijeta. Članek poskuša v kontekstu Anti-Ojdipa in prek branja Genealogije morale natančneje zastaviti problem spomina ter dlje razviti pojmovanje in vlogo biofiliacijskega spomina.

Стилі APA, Harvard, Vancouver, ISO та ін.

44

Barši, Izidor. "Univerzalna zgodovina spomina." Ars & Humanitas 12, no. 2 (December 27, 2018): 41–55. http://dx.doi.org/10.4312/ars.12.2.41-55.

Повний текст джерела

Анотація:

V knjigi Anti-Ojdip Gilles Deleuze in Felix Guattari razločujeta med dvema vrstama spomina: besednim ali aliansnim ter biofiliacijskim. V njuni koncepciji družbe primata nima menjava, temveč dolg: temeljno družbeno razmerje je torej razmerje med upnikom in dolžnikom. Nujni pogoj tega razmerja je spomin, ki zagotavlja, da dolg ni pozabljen. Vendar ta spomin ni samoumeven, ampak ga je bilo treba človeku šele narediti. To »predzgodovinsko delo človeka« Deleuze in Guattari interpretirata kot osrednji napor »primitivnega sociusa«, ki sestoji iz vseh krutih tehnik vpisovanja v telo, kar imenujeta »sistem krutosti«. Avtorja se opreta na Nietzschejevo Genealogijo morale in trdita, da se besedni spomin vzpostavi na podlagi »aktivne sposobnosti pozabe« in s »potlačitvijo biološkega spomina«. Če je sredstvo vzpostavitve besednega spomina sistem krutosti in njen agens aliansa oziroma primitivni socius sam, kaj točno je potlačitev in kaj je tisto, kar je potlačeno? Biofiliacijski spomin imenujeta tudi »intenzivni spomin filiacije«, »spomin učinkov« ter »biokozmični spomin«, vendar v knjigi njegovega pojmovanja ne razvijeta. Članek poskuša v kontekstu Anti-Ojdipa in prek branja Genealogije morale natančneje zastaviti problem spomina ter dlje razviti pojmovanje in vlogo biofiliacijskega spomina.

Стилі APA, Harvard, Vancouver, ISO та ін.

45

Triwitayakorn, K., and A. J. Wood. "Characterisation of two desiccation-stress related cDNAs TrDr1 and TrDr2 in the resurrection moss Tortula ruralis." South African Journal of Botany 68, no. 4 (December 2002): 545–48. http://dx.doi.org/10.1016/s0254-6299(15)30383-5.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

46

Antonacci, R., C. Lanave, L. Del Faro, G. Vaccarelli, S. Ciccarese, and S. Massari. "Artiodactyl emergence is accompanied by the birth of an extensive pool of diverse germline TRDV1 genes." Immunogenetics 57, no. 3-4 (March 9, 2005): 254–66. http://dx.doi.org/10.1007/s00251-005-0773-7.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

47

Güler, Hande. "Influence of the tool geometry and process parameters on the static strength and hardness of friction-stir spot-welded aluminium-alloy sheets." Materiali in tehnologije 49, no. 3 (May 7, 2015): 457–60. http://dx.doi.org/10.17222/mit.2014.087.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

48

SARKAR, NANTU, and ABHIJIT LAHIRI. "TEMPERATURE RATE DEPENDENT GENERALIZED THERMOELASTICITY WITH MODIFIED OHM'S LAW." International Journal of Computational Materials Science and Engineering 01, no. 04 (December 2012): 1250031. http://dx.doi.org/10.1142/s2047684112500315.

Повний текст джерела

Анотація:

The present work is concerned with an electro-magneto-thermoelastic coupled problem for a homogeneous, isotropic, thermally and electrically conducting semi-infinite solid medium in two-dimensional space where an initial magnetic field with constant intensity acts parallel to the plane boundary of the half-space. The surface of the half-space taking as traction free which is subjected to a thermal shock. The modified Ohm's law including the temperature gradient and charge density effect to the governing equations of the generalized thermoelasticity under the temperature rate dependent thermoelasticity (TRDTE) proposed by Green and Lindsay (GL model) has been introduced. Normal mode analysis together with eigenvalue approach technique is used to obtain the general solutions for the physical quantities. Numerical results for the physical quantities are illustrated graphically and analyzed. The graphical results indicate that the effect of the coefficient connecting the temperature gradient and the electric current density of the modified Ohm's law on the plane waves is very pronounced. Comparison are made with the results obtained in the absence of the above coefficient.

Стилі APA, Harvard, Vancouver, ISO та ін.

49

Petrovčič, Andraž, and Gregor Petrič. "Factors of collective psychological empowerment of active users in the online health community med.over.net." Slovenian Journal of Public Health 53, no. 2 (June 1, 2014): 133–43. http://dx.doi.org/10.2478/sjph-2014-0014.

Повний текст джерела

Анотація:

Izvleček Namen: V članku raziskujemo v literaturi pogosto spregledano vprašanje kolektivnega psihološkega opolnomočenja uporabnikov spletnih zdravstvenih skupnosti. Izhajajoč iz teorij opolnomočenja s področja psihologije skupnosti, preverjamo, kateri dejavniki, ki obenem odražajo pomembne lastnosti spletnih zdravstvenih skupnosti, so povezani s kolektivnim psihološkim opolnomočenjem njihovih uporabnikov. Metode: Vlogo štirih dejavnikov kolektivnega opolnomočenja smo analizirali s pomočjo multiple linearne regresije na podatkih, zbranih konec leta 2010 s spletno anketo na neverjetnostnem vzorcu (n = 235) aktivnih sodelujočih na forumih največje slovenske spletne zdravstvene skupnosti Med.over.net, ki je vključeval 8,5% moških, 49,7% vsaj visoko izobraženih in 41,5% poročenih anketirancev, ki so bili v povprečju stari 35,1 leta (SD = 9,1). Rezultati: Ugotavljamo, da se predstavljeni teoretični model dejavnikov ustrezno prilega podatkom (F = 8,65, df = 8, p < 0,001) in z njim lahko pojasnimo 23,4% variabilnosti občutka kolektivnega opolnomočenja. Občutek pripadnosti spletni skupnosti (β = 0,279, p < 0,001), vključenost v organizacijske aktivnosti skupnosti (0,194, 0,001) in zaznana participacija spletne skupnosti v širšem okolju (0,157, 0,02) vplivajo na kolektivno opolnomočenje uporabnikov spletne zdravstvene skupnosti Med.over.net, medtem ko tega ni mogoče trditi za intenzivnost participacije v forumskih razpravah (0,029, 0,65). Zaključek: Za povečevanje kolektivne komponente psihološkega opolnomočenja uporabnikov spletnih zdravstvenih skupnosti je treba v prvi vrsti graditi na kakovosti odnosov med člani, vključevanju članov v strateške odločitve o skupnosti in na vključenosti skupnosti v širše družbeno okolje, saj sama participacija uporabnikov v spletnih skupnosti še ne zagotavlja njihovega višjega kolektivnega opolnomočenja.

Стилі APA, Harvard, Vancouver, ISO та ін.

50

Jin, Zhenyi, Qiang Luo, Xinyu Wang, Zifan He, Jing Lai, Shaohua Chen, Lijian Yang, Bo Li, Xiuli Wu та Yangqiu Li. "Oligoclonal Expansion of TCR Vδ T Cells May be a Potential Immune Biomarker for AML Outcome". Blood 128, № 22 (2 грудня 2016): 5237. http://dx.doi.org/10.1182/blood.v128.22.5237.5237.

Повний текст джерела

Анотація:

Abstract Background: Recent data showed that gamma delta T cells can act as a vast functional setting of immune defense against tumors. Our previous study found that persist clonally expanded TRDV4 T cells might be relatively to better outcome for the patient with T-cell acute lymphoblastic leukemia (T-ALL) after hematopoietic stem cell transplantation (HSCT). However, little is known, the distribution and clonality of TRDV repertoire of gamma delta T cells in peripheral blood (PB) and its potential effect for clinical outcome in acute myeloid leukemia (AML) patients. Methods: Gamma delta T cells were sorted from peripheral blood of 30 patients with untreated de novo AML (AML-M0 6 cases, M1 1 case, M2 5 cases, M3 10 cases, M4 3 cases and M5 5 cases) and were observed the distribution of TRDV repertoire, while 12 healthy individuals served as normal controls. Then the TRDV repertoire were further analyzed by Genescan technique to determine the size of complementarity determining region 3 (CDR3) of TRDV (1-8) subfamilies genes and to evaluate the clonality of the detectable subfamilies of gamma delta cells. The binary Logistic regression analysis was used to explore the associations between clonal expansion of gamma delta T cells and outcome of AML patients. Results: The frequencies of TRDV1, TRDV3, TRDV4 and TRDV6 in gamma delta T cells from AML patients were significantly lower than that from healthy individuals (HI) (Figure A). The most frequently expanded TRDV subfamilies in AML patients were TRDV8 (56.67%) and TRDV4 (40%). Furthermore, the most frequently oligoclonally expanded TRDV subfamilies from AML patients were TRDV2 and TRDV4 subfamilies, and the clonal expansion frequencies were significant higher than that from healthy individuals, however, a significant lower clonal expansion frequency of TRDV1 was observed in AML patients (Figure B). Importantly, oligoclonalities of TRDV4 and TRDV8subfamilies were the independent protective factors for complete remission. In addition, the oligoclonal expansion frequencies of TRDV5 and TRDV6 subfamilies from the recurrence cases were significantly higher than that from non-recurrence cases. Significantly, oligoclonal TRDV5 and TRDV6subfamilies were found in the patients who developed AML relapse in different time point after first complete remission. Conclusions: The distribution and clonality of TRDV subfamilies significantly changed in gamma delta T cells from AML patients. Clonally expanded TRDV4 and TRDV8 T cells might contribute to immune response against AML, while oligoclonal TRDV5 and TRDV6 may be accompanied to patients who underwent AML relapse, the function of such oligoclones of gamma delta T cells is needed further investigation. Overall, these TRDV gamma delta T cell clones might be a potential immune biomarker for AML outcome. Foundation: This study was supported by grants from Natural Science Foundation of China (No.81200388), Natural Science Foundation of Guangdong Province (NO.2014A030313380) and the Project of the Zhujiang Science & Technology Star of Guangzhou City (No. 2013J2200046). Figure Figure. Disclosures No relevant conflicts of interest to declare.

Стилі APA, Harvard, Vancouver, ISO та ін.

Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!